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EC Number
Activating Compound
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Reference
1.3.8.8
bezafibrate
increased VLCAD residual enzyme activity in the presence of 0.4 mM bezafibrate
684281
1.3.8.8
bezafibrate
stimulates VLCAD gene expression to 44% in normal and to 150% in VLCAD-deficient fibroblasts, increases activity 2.2fold in normal fibroblasts, induces a dose-dependent increase in palmitate oxidation capacities in cells from patients with the myopathic form of VLCAD deficiency, complete normalization of cell fatty acid oxidation capacities after exposure to 500 mM for 48 h, but not in cells from severely affected patients
673935
1.3.8.8
Clofibrate
activation, treated animals receiving 0.5% w/w neutralized acid for 2 weeks
391298
1.3.8.8
peroxisome proliferator
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671275
1.3.8.8
Triton X-100
restores activity during ischemia
671584
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