EC Number |
Activating Compound |
Reference |
---|
1.1.1.41 | ADP |
- |
286775, 760834, 761502, 762451 |
1.1.1.41 | ADP |
activates. Michaelis-Menten constant for DL-isocitrate is lowered 3.5-fold in the wild-type IDH. The substitution of asparagine for aspartate in alpha-mutant enzyme D181N, beta-subunit mutant enzyme D192N, and gamma-subunit mutant enzyme D190N abolishes this allosteric effect of ADP on Km |
685154 |
1.1.1.41 | ADP |
allosteric activation by ADP involving residue betaY126. In the presence of 1 mM ADP, the Km,isocitrate is reduced almost equally in the wild-type, 3.6fold, and the alphaY126E mutant, 4.3fold |
712440 |
1.1.1.41 | ADP |
allosteric regulation, determination of mol ADP bound to an enzyme tetramer of wild-type and mutant enzymes at different starting concentrations, overview |
656189 |
1.1.1.41 | ADP |
the alpha2betagamma heterotetramer and alphagamma heterodimer can be allosterically activated by ADP |
762437 |
1.1.1.41 | AMP |
- |
286749, 286772, 654783 |
1.1.1.41 | AMP |
activates ICDH-1 |
286776 |
1.1.1.41 | AMP |
activation of the enzyme and reduction of enzyme inhibition by mitochondrial mRNA, highly enhanced by presence of isocitrate, complex formation, overview |
654652 |
1.1.1.41 | AMP |
allosteric activation |
656052 |
1.1.1.41 | AMP |
allosteric activation, binds to subunit IDH1 |
721433 |