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Results 1 - 10 of 29 > >>
EC Number
Activating Compound
Commentary
Reference
2'-deoxy-GTP
0 mM guanosine, kact: 1.5/sec, KA: 0.21 mM, Ki: 0.36 mM; the GTP analogue is capable of activating Gln-dependent CTP formation
2-mercaptoethanol
required for optimal activity, above 50 mM increase activity to 221%
2-mercaptoethanol
stimulates
6-thio-GTP
the GTP analogue is capable of activating Gln-dependent CTP formation
6-thioguanosine 5'-triphosphate
0 mM guanosine, kact: 8.5/sec, KA: 0.035 mM, Ki: 0.27 mM
dithiothreitol
required for optimal activity, above 50 mM increase activity to 223% mM
GDP
slight activation
GMP
slight activation
GTP
0.1 mM guanosine, kact: 10.3/sec, KA: 0.088 mM, Ki: 0.22 mM; 0.2 mM guanosine, kact: 8.2/sec, KA: 0.078 mM, Ki: 0.12 mM; 0 mM guanosine, kact: 10.6/sec, KA: 0.081 mM, Ki: 0.28 mM; allosteric effector, structural requirements for activation are stringent, but requirements for inhibition are lax. GTP promotes Gln hydrolysis but inhibits Gln-dependent CTP formation at concentrations of over 0.15 mM
Results 1 - 10 of 29 > >>