EC Number   |
Activating Compound |
Reference  |
|---|
   3.4.22.49 | securin |
- |
638862 |
| 3.4.22.49 | securin |
activation may be due to separase localization |
638862 |
| 3.4.22.49 | securin |
securin is required to support separase activity in anaphase |
638864 |
| 3.4.22.49 | more |
separase shows self-cleavage upon activation |
664553 |
| 3.4.22.49 | securin |
the central domain of securin has a functionally essential specific sequence that may directly interact with the catalytic region of separase. This central securin domain is unrelated to destruction by polyubiquitination, but essential for the activation of separase |
665049 |
| 3.4.22.49 | more |
separase can be activated by incubating immunoglobulin G-Sepharose 6 containing ZZ TEV4-separase with anaphase-initiated Xenopus cytostatic factor to degrade its inhibitor securin at room temperature for 1 h |
707105 |
| 3.4.22.49 | more |
Cdc20 is essential for mitotic progression |
718037 |
| 3.4.22.49 | DNA |
chromosomal DNA is required as a cofactor for the cleavage of cohesin to occur, and allows separase to selectively cleave only the chromosome-associated cohesin |
718177 |
| 3.4.22.49 | DNA |
chromosomal DNA is required as a cofactor for the cleavage of cohesin to occur, and allows separase to selectively cleave only the chromosome-associated cohesin. Separase binds to DNA in a sequence nonspecific manner in vitro and associates with the entire length of the mitotic chromosomes |
718177 |
| 3.4.22.49 | more |
most of the budding yeast cohesin is cleaved in anaphase, and this cleavage is stimulated by phosphorylation of the Scc1 subunit by the Plk1 kinase |
718177 |
