EC Number   |
Activating Compound |
Reference |
|---|
   3.4.22.49 | cyclinB1 |
- |
732703 |
| 3.4.22.49 | PP2A |
- |
732703 |
| 3.4.22.49 | securin |
- |
638862 |
| 3.4.22.49 | securing |
- |
732703 |
| 3.4.22.49 | securin |
activation may be due to separase localization |
638862 |
| 3.4.22.49 | imatinib |
activation of separase proteolytic activity occurs exclusively in BCR-ABL-positive cells during imatinib treatment (0.00025-0.01 mM for 24 h) |
732703 |
| 3.4.22.49 | more |
Cdc20 is essential for mitotic progression |
718037 |
| 3.4.22.49 | cell division cycle 6 |
Cdc6, a mitotic substrate of polo-like kinase. Cleavage of chesin/Rad21 is much greater in wild-type Cdc6 expressing cells than in GFP and Cdc6-T37V mutant expressing cells |
718320 |
| 3.4.22.49 | DNA |
chromosomal DNA is required as a cofactor for the cleavage of cohesin to occur, and allows separase to selectively cleave only the chromosome-associated cohesin |
718177 |
| 3.4.22.49 | DNA |
chromosomal DNA is required as a cofactor for the cleavage of cohesin to occur, and allows separase to selectively cleave only the chromosome-associated cohesin. Separase binds to DNA in a sequence nonspecific manner in vitro and associates with the entire length of the mitotic chromosomes |
718177 |
