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EC Number	Activating Compound	Commentary	Reference
3.4.19.3	1,10-phenanthroline	weak activation	95283
3.4.19.3	cyclosporin	increases particulate and soluble PAP activity in the renal cortex. Particulate PAP activity returns to levels similar to controls after 15 days of cyclosporin withdrawal, soluble PAP does not regress. Soluble and particulate aminopeptidases in resident and elicited macrophages are unaffected by cyclosporin	680172
3.4.19.3	DFP	weak activation	95283
3.4.19.3	dithiothreitol	-	678405, 682806
3.4.19.3	dithiothreitol	absolute requirement for maintenance of activity	95301
3.4.19.3	dithiothreitol	at least 10 mM required for full activity	681817
3.4.19.3	dithiothreitol	presence of disulfide-reducing agent such as dithiothreitol required	95296
3.4.19.3	dithiothreitol	rapid increase in activity from 2 to 6 mM, above this concentration plateau effect	681896
3.4.19.3	dithiothreitol	strongly stimulates activity of wild-type enzyme and mutant enzyme C188S and shifts the pH-optimum to higher temperatures by about 10°C	651099
3.4.19.3	DTT	enhances activity	653129

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Release 2023.1 (January 2023)