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Results 1 - 9 of 9
EC Number
Activating Compound
Commentary
Reference
8-[[2-(dimethylamino)ethyl]amino]-5-(hydroxymethyl)-9-oxo-9H-xanthen-2-yl 4-methylbenzenesulfonate
enhances ACE2 activity in a dose-dependent manner and causes considerable reductions in blood pressure and a striking reversal of cardiac and renal fibrosis in the spontaneously hypertensive rat model of hypertension
all-trans retinoic acid
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D-glucose
incubation of cells in high D-glucose increases ACE2 activity
losartan
a specific angiotensin II receptor antagonist, is a well-known antihypertensive drug with a potential role in positively regulating ACE2 in the lung
losartan
an angiotensin II type 1 receptor blocker, increases central ACE2 activity. Losartan also restores brain ACE2 activity in transgenic RA mice, overview
more
no activation by PD123319, an angiotensin II type 2 antagonist
resorcinolnaphthalein
enhances ACE2 activity in a dose-dependent manner
XNT
activates ACE2, reduces platelet attachment to injured vessels, reduces thrombus size, and prolonges the time for complete vessel occlusion in mice. Thrombus area is reduced by 60%, whereas time for thrombus formation is prolonged by 45% in XNT-treated mice
XNT
treatment at 10 mg/kg resultes in a 30% attenuation of thrombus formation in the SHR
Results 1 - 9 of 9