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EC Number
Activating Compound
Commentary
Reference
cellular retinol-binding protein
CRBP, required for enzyme activity, CRBP-I and CRBP-III each compensate for the absence of the other, specifically in mammary tissue, adipose tissue, muscle, and heart
cellular retinol-binding protein
i.e. CRALBP, in presence of palmitoyl-CoA and CRALBP, Muller cell membranes synthesize 11-cis-retinyl ester from 11-cis-retinol at a rate which is 20fold higher than that of all-trans-retinyl ester, in absence of CRALBP, 11-cis-retinyl ester synthesis is greatly reduced by 7fold
more
activation and mRNA expression for LRAT is blocked completely in vivo by actinomycin D; activation is blocked completely in vivo by cycloheximide
more
activation and mRNA expression for LRAT is blocked completely in vivo by actinomycin D; retinoic acid must be continuously present to maintain LRAT gene expression in the ON position
more
the pollutant 2,3,7,8-tetrachlorodibenzo-4-dioxin, i.e. TCDD, induces enzyme expression in the kidney, induction mechanism, the expression of the cellular retinol binding protein I is unaffected, TCDD alters the retinoid metabolism regulation, expression and activity of cytochrome P450 A1 increases retinoic acid levels in kidney and liver, and enhances enzyme expression in the kidney
N-(4-hydroxyphenyl)-retinamide
necessary dose, 0.5 mg; restores normal level of LRAT activity in vitamin A depleted rats
retinoic acid
-
retinoic acid
minimal dose for significant increase in LRAT activity and mRNA expression: 0.005 mg
retinoic acid
optimal dose, 0.020 mg; restores normal level of liver LRAT activity in vitamin A deficient and depleted rats
retinol
-
Results 1 - 10 of 13 > >>