EC Number |
Activating Compound |
Reference |
---|
2.1.1.137 | coenzyme M |
- |
733740 |
2.1.1.137 | dimethylselenoxide |
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes |
658442 |
2.1.1.137 | dithiothreitol |
- |
485152, 733740 |
2.1.1.137 | dithiothreitol |
weak activation |
485148 |
2.1.1.137 | glutathione |
- |
485152 |
2.1.1.137 | glutathione |
1 mM GSH decreases Km and increases Vmax estimates for arsenite and methylarsonous acid |
721075 |
2.1.1.137 | glutathione |
a 4fold increase in glutathione concentration, 2 to 8 mM, leads to a 2fold increase in enzyme activity, reducing environment is required for enzyme activity |
485148 |
2.1.1.137 | glutathione |
ArsM is able to methylate As(III) in the presence of Cys without glutathione. In contrast, ArsM is not able to methylate As(III) in the presence of tris(2-carboxyethyl)phosphine without GSH |
757684 |
2.1.1.137 | glutathione |
As(III) SAM methyltransferase conducts three successive rounds of oxidative methylation, with the glutathione conjugates serving as metalloid donors to the enzyme |
718946 |
2.1.1.137 | glutathione |
GSH should combine with the enzyme after the methylation to reduce the disulfide bond formed during the catalytic cycle to resume the active form of the enzyme |
719007 |