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EC Number
Activating Compound
Commentary
Reference
coenzyme M
-
dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
dithiothreitol
-
dithiothreitol
weak activation
glutathione
-
glutathione
1 mM GSH decreases Km and increases Vmax estimates for arsenite and methylarsonous acid
glutathione
a 4fold increase in glutathione concentration, 2 to 8 mM, leads to a 2fold increase in enzyme activity, reducing environment is required for enzyme activity
glutathione
As(III) SAM methyltransferase conducts three successive rounds of oxidative methylation, with the glutathione conjugates serving as metalloid donors to the enzyme
glutathione
GSH should combine with the enzyme after the methylation to reduce the disulfide bond formed during the catalytic cycle to resume the active form of the enzyme
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