1.14.15.16 | 1alpha,25-dihydroxyvitamin D3 |
renal 24-hydroxylase is significantly stimulated by 1alpha,25-dihydroxyvitamin D3 treatment in both normal and Hyp mice. In normal mice, 1alpha,25-dihydroxyvitamin D3 treatment is more effective than calcium in turning on 24-hydroxylase activity. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone. 24-hydroxylase is 3fold, and 8fold greater in Hyp mice relative to normal treated with 1alpha,25-dihydroxyvitamin D3, and calcium plus 1alpha,25-dihydroxyvitamin D3, respectively |
714835 |