EC Number   |
Activating Compound  |
Reference |
|---|
    1.13.11.34 | (13S)-hydroperoxy-9,11-octadecadienoic acid |
- |
687264 |
| 1.13.11.34 | (13S)-hydroperoxy-9,11-octadecadienoyl lysophosphatidylcholine |
50% activation concentration AC50 is 0.0015 mM |
687264 |
| 1.13.11.34 | 1,25(OH)2D3 |
gives a strong (100fold) upregulation of 5-lipoxygenase protein in differentiating Mono Mac 6 cells |
704997 |
| 1.13.11.34 | 5,8,11,14,17-eicosapentaenoic acid |
competitive inhibition of oxygenation of arachidonic acid |
439466 |
| 1.13.11.34 | 5-lipoxygenase activating protein |
5-lipoxygenase activating protein is crucial for conversion of endogenous substrate by 5LO 5-lipoxygenase activating protein also stimulates the utilization of exogenous arachidonic acid, and greatly (190fold) stimulates utilization of (5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid |
711100 |
| 1.13.11.34 | 5-lipoxygenase-activating protein |
a 18000 Da integral membrane protein required, in peripheral cells, for the activation of 5-lipoxygenase |
439477 |
| 1.13.11.34 | 5-lipoxygenase-activating protein |
functional 5-LOX requires binding to 5-lipoxygenase-activating protein which helps 5-LOX binding to arachidonic acid at the nuclear membrane and enhances the efficiency of leukotriene synthesis |
711045 |
| 1.13.11.34 | 5-LO activating protein |
i.e. FLAP, Ca2+ induces the translocation of 5-LO from a soluble compartment to nuclear structures, where 5-LO co-localizes with 5-LO activating protein |
689872 |
| 1.13.11.34 | 5-LO-activating protein |
i.e. FLAP, a small permanently membrane-bound protein that is essential for the biosynthesis of leukotrienes from endogenous arachidonic acid. FLAP binds arachidonic acid and is thought to assist in the provision of substrate to 5-LO |
690170 |
| 1.13.11.34 | 5-LOX activating protein |
- |
711661 |
