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Results 1 - 10 of 64 > >>
EC Number
Activating Compound
Commentary
Reference
(13S)-hydroperoxy-9,11-octadecadienoic acid
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(13S)-hydroperoxy-9,11-octadecadienoyl lysophosphatidylcholine
50% activation concentration AC50 is 0.0015 mM
1,25(OH)2D3
gives a strong (100fold) upregulation of 5-lipoxygenase protein in differentiating Mono Mac 6 cells
5,8,11,14,17-eicosapentaenoic acid
competitive inhibition of oxygenation of arachidonic acid
5-lipoxygenase activating protein
5-lipoxygenase activating protein is crucial for conversion of endogenous substrate by 5LO 5-lipoxygenase activating protein also stimulates the utilization of exogenous arachidonic acid, and greatly (190fold) stimulates utilization of (5Z,8Z,10E,12S,14Z)-12-hydroxyicosa-5,8,10,14-tetraenoic acid
5-lipoxygenase-activating protein
a 18000 Da integral membrane protein required, in peripheral cells, for the activation of 5-lipoxygenase
5-lipoxygenase-activating protein
functional 5-LOX requires binding to 5-lipoxygenase-activating protein which helps 5-LOX binding to arachidonic acid at the nuclear membrane and enhances the efficiency of leukotriene synthesis
5-LO activating protein
i.e. FLAP, Ca2+ induces the translocation of 5-LO from a soluble compartment to nuclear structures, where 5-LO co-localizes with 5-LO activating protein
5-LO-activating protein
i.e. FLAP, a small permanently membrane-bound protein that is essential for the biosynthesis of leukotrienes from endogenous arachidonic acid. FLAP binds arachidonic acid and is thought to assist in the provision of substrate to 5-LO
5-LOX activating protein
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Results 1 - 10 of 64 > >>