EC Number |
Activating Compound |
Reference |
---|
3.4.22.55 | more |
etoposide, staurosporine, pacritaxel and cyclohexamide treatment promotes exon 9-inclusion, increasing the ratio of caspase-2S to caspase-2L |
665952 |
3.4.22.55 | more |
genotoxic stress |
665588 |
3.4.22.55 | more |
heat shock, UV irradiation and anti-Fas treatment activate caspase-2 |
666419 |
3.4.22.55 | more |
photodynamic treatment, incubation with zinc(II)-phthalocyanine (0.0005 mM and 0.001 mM)and irradiated with red light |
665247 |
3.4.22.55 | more |
the enzyme is activated during apoptosis by a caspase-3 (CPP32)-like protease. When cells are induced to undergo apoptosis, endogenous caspase-2 is first cleaved into three fragments of 32000-33000 Da and 14000 Da, which are then further processed into 18000 Da and 12000 Da active subunits |
647763 |
3.4.22.55 | more |
the topoisomerase-II inhibitor etoposide induces processing of procaspase-2 |
717457 |
3.4.22.55 | more |
when protein kinase CK2 activity is low, procaspase-2 is dephosphorylated, dimerized, and activated in a PIDDosome-independent manner |
664753 |
3.4.22.55 | P53 |
p53 induces PIDD expression resulting in a feed-forward loop |
717458 |
3.4.22.55 | p53-induced protein with a death domain |
PIDD, caspase-2 is activated by the p53 target gene product PIDD, i.e. LRDD or leucine-rich repeats and death domain containing, in a complex called the caspase-2-PIDDosome |
718112 |
3.4.22.55 | p53-inducible death domain-containing protein |
PIDD |
663875 |