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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.49securin - 638862
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.49securin activation may be due to separase localization 638862
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.49securin securin is required to support separase activity in anaphase 638864
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.49securin the central domain of securin has a functionally essential specific sequence that may directly interact with the catalytic region of separase. This central securin domain is unrelated to destruction by polyubiquitination, but essential for the activation of separase 665049
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.49securing - 732703
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.49securing the motif containing H134 in securing isoform PTTG1 has a strong affinity for separase and is involved in inhibiting it, while another domain(s) in isoform PTTG2 is involved in activating separase and has a weaker affinity for it. Isoform PTTG2 does not interact with separase 732505
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