BRENDA Enzyme Database - JSON download file

Type: object

Contents of the BRENDA json download file.
Download is avaliable at www.brenda-enzymes.org.

No Additional Properties

Type: string

The BRENDA release number of the data.

Must match regular expression: 2[0-9]{3}\.(?:1|2)

Type: string

The version number of the schema used.

Type: object

All data entries for annotated enzymes.

All properties whose name matches the following regular expression must respect the following conditions

Property name regular expression: ^(?:[1-7]\.[1-9][0-9]{0,2}\.[1-9][0-9]{0,2}\.B?[1-7][0-9]{0,2})|spontaneous$
Type: object

Contents of a BRENDA enzyme entry.
This is part of the BRENDA json download file.

No Additional Properties

Type: string

Unique identifier of the enzyme. For enzymes, the Enzyme Commission number (EC Number) given by the IUBMB (International Union of Biochemistry and Molecular Biology), classes of enzymes und subclasses based on the reaction they catalyze. For spontaneous, non-enzymatic reactions the id is spontaneous.

Must match regular expression: ^(?:[1-7]\.[1-9][0-9]{0,2}\.[1-9][0-9]{0,2}\.B?[1-7][0-9]{0,2})|spontaneous$

Type: string

The recommended or accepted name of an enzyme as given by the IUBMB.

Type: string

The systematic name fields provides a chemically more precise name and is usaually based on the substrate or, in the case of a bimolecular reaction, of the two substrates separated by a colon, and the nature of the reaction.

Type: array

Synonyms comprise names by which an enzyme is known. The names are found found in other databases or in the literature, abbreviations, names of commercially available products or gene names.

Each item of this array must be:

Type: array

Information on the X-ray structure of an enzyme and the procedure and conditions of the crystallization are described.

Each item of this array must be:

Type: array

Information on the renaturation, refolding and reactivation procedures of enzymes after denaturation processes.

Each item of this array must be:

Type: array

General information on enzyme stability.

Each item of this array must be:

Type: array

The influence of oxidating agents on enzyme stability.

Each item of this array must be:

Type: array

The influence of storage duration and conditions such as temperature, pH, additives etc. on the enzyme stability and activity.

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Type: array

A generalized form of reactions catalyzed by the enzyme.

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Type: array

The reaction catalyzed by the enzyme under physiological conditions.

Each item of this array must be:

Type: array

The reaction catalyzed by the enzyme.

Each item of this array must be:

Type: array

The rate at which an enzyme converts its substrate in 1/s.

Each item of this array must be:

Type: array

The Michaelis-Menten constant of the enzyme in mM.

Each item of this array must be:

Type: array

The pH where the enzymes activity is at its maximum.

Each item of this array must be:

Type: array

pH range in which the enzyme is active.

Each item of this array must be:

Type: array

The pH stability of the enzyme.

Each item of this array must be:

Type: array

The specific activity of the enzyme in µmol/min/mg.

Each item of this array must be:

Type: array

The temperature where the enzymes activity is at its maximum in °C.

Each item of this array must be:

Type: array

Temperature range in which the enzyme is active in °C.

Each item of this array must be:

Type: array

The temperature stability of the enzyme in °C.

Each item of this array must be:

Type: array

The molecular weight of the holoenzyme. For monomeric enzymes the MW is identical to the value given for subunits.

Each item of this array must be:

Type: array

The pH value at which the protein carries no net electrical charge.

Each item of this array must be:

Type: array

The inhibition constant in mM. Each value is connected to an inhibitor (value property).

Each item of this array must be:

Type: array

The half maximal inhibitory concentration of a compund in mM. Each value is connected to an inhibitor (value property).

Each item of this array must be:

Type: array

The catalytic efficiency of the enzyme in mM/s. Each value is connected to a substrate (value property).

Each item of this array must be:

Type: array

The intracellular localization of the enzyme.

Each item of this array must be:

Type: array

For multicellular organisms the tissues used for isolation of the enzyme or the tissue in which the enzyme is present. Cell-lines can also be a source of enzymes.

Each item of this array must be:

Type: array

Compounds that have a positive effects on the activity of the enzyme, except metal ions and cofactors.

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Type: array

Compounds found to be inhibitory to the enzyme.

Each item of this array must be:

Type: array

The ions or salts that have activating effects, or are closely bound to the enzyme.

Each item of this array must be:

Type: array

This field describes covalent and general enzyme modifications following protein biosynthesis.

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Type: array

The tertiary structure of the active enzyme is described. It can be active as a monomer, dimer, trimer etc. The stoichiometry of the subunits is given.

Each item of this array must be:

Type: array

All compounds which participate in the reaction, which are loosely-bound to the protein and are required for the enzyme activity, whereas prosthetic groups are tightly-bound to the enzyme.

Each item of this array must be:

Type: array

Information on expresssion and cloning procedures and systems are given and in which organism or cell culture an enzyme is expressed in.

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Type: array

The enzyme stability in presence of organic solvents is described.

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Type: array

This information field describes the effect of compounds and/or conditions on the expression of enzymes leading to an up- or downregulation.

Each item of this array must be:

Type: array

This field contains more general information on the role of an enzyme in the metabolism, the physiological function, a possible malfunction, or evolutionary aspects.

Each item of this array must be:

Type: object

Protein/gene accessions associated with the data field.

All properties whose name matches the following regular expression must respect the following conditions

Property name regular expression: ^[1-9][0-9]{0,}$
Type: array

Must contain a minimum of 1 items

Each item of this array must be:

Type: object

Type: array of string

Must contain a minimum of 1 items

Each item of this array must be:

Type: enum (of string)

Must be one of:

  • "uniprot"
  • "genbank"

Type: object

The references associated with the data field.

All properties whose name matches the following regular expression must respect the following conditions

Property name regular expression: ^[1-9][0-9]{0,}$
Type: object

Type: string
Must match regular expression: [1-9][0-9]{0,}

Type: array of string

Must contain a minimum of 1 items

Each item of this array must be:

Type: integer

Value must be greater or equal to 1600

Type: object

The organisms associated with the data field.

All properties whose name matches the following regular expression must respect the following conditions

Property name regular expression: ^[1-9][0-9]{0,}$
Type: object