1.4.1.B2 A179S/E310G/G323S/H328N mutant exhibited an about 200 times enhanced activity towards substrate (R)-beta-homomethionine compared to mutant E310G and increased activities with (S)-beta-homolysine, (S)-beta-aminobutyric acid, (R)-beta-phenylalanine, (S)-beta-homophenylalanine 762604 1.4.1.B2 D177A 0.15% of wild-type activity towards L-erythro-3,5-diaminohexanoate -, 762604 1.4.1.B2 D177E 7% of wild-type activity towards L-erythro-3,5-diaminohexanoate 762604 1.4.1.B2 D177H 0.1% of wild-type activity towards L-erythro-3,5-diaminohexanoate 762604 1.4.1.B2 D177K almost complete loss of activity towards L-erythro-3,5-diaminohexanoate 762604 1.4.1.B2 D177N 0.15% of wild-type activity towards L-erythro-3,5-diaminohexanoate -, 762604 1.4.1.B2 D177R 0.5% of wild-type activity towards L-erythro-3,5-diaminohexanoate 762604 1.4.1.B2 D49A loss of activity towards L-erythro-3,5-diaminohexanoate -, 762604 1.4.1.B2 D49E 0.1% of wild-type activity towards L-erythro-3,5-diaminohexanoate 762604 1.4.1.B2 D49N less than 0.1% of wild-type activity towards L-erythro-3,5-diaminohexanoate -, 762604