5.1.3.37 D152G mutation eliminates almost all of both the lyase and epimerase activities 652156 5.1.3.37 D173E 54% residual activity 734159 5.1.3.37 D178E complete loss of activity 734159 5.1.3.37 D178N complete loss of activity 734159 5.1.3.37 D317A about 5% of wild-type activity 734293 5.1.3.37 D320A complete loss of activity -, 734293 5.1.3.37 D368N about 5% of wild-type activity -, 734293 5.1.3.37 D452A about 70% of wild-type activity 734293 5.1.3.37 F122Y 65% residual activity 734159 5.1.3.37 H154F complete loss of activity 734159