3.4.22.43 additional information cathepsin V enzyme knockout by siRNA transfection of THP-1 cells 754753 3.4.22.43 additional information CTSV knockdown by RNAi 753828 3.4.22.43 additional information siRNA knockdown of CTSV in keratinocytes. Inhibition of CTSV expression increases melanosome accumulation in HaCaT keratinocytes. The rate of melanosome degradation is reduced in CTSV knockdown keratinocytes 752678 3.4.22.43 additional information the enzyme can complement cathepsin L-deficient mice by expression of cathepsin V in epidermis and hair follicles, the mutant mice suffer from a complex skin phenotype consisting of hair loss and epidermal hyperplasia with hyperproliferation of basal epidermal keratinocytes, acanthosis, and hyperkeratosis, overview 668472