3.4.18.1 D253K reversed polarity and improved activity 36392 3.4.18.1 D253R reversed polarity and improved activity 36392 3.4.18.1 G251T/D253K double mutant, improved activity 36392 3.4.18.1 additional information - 36392 3.4.18.1 additional information cathepsin X overexpression reduces LFA-1 clustering and induces an intermediate affinity LFA-1 conformation that is known to associate with alpha-actinin-1. Migration of primary T cell is reduced by cathepsin X-specific siRNA silencing 708379 3.4.18.1 additional information cell surface cathepsin X compensates for CTSB in PyMT,ctsb-/- tumor cells, overview 679023 3.4.18.1 additional information generation of Ctsz null mice and crossing with Ctsb-deficient mice harboring a transgene for the mammary duct-specific expression of polyoma middle T oncogene, PymT. The double mutant mice show significant and prominent delay of early and advanced tumor development, improved histopathologic tumor grading, as well as a 70% reduction in the number of lung metastases and an 80% reduction in the size of these metastases. The double deficiency of Ctsb and Ctsz exerts significant synergistic anticancer effects, whereas the single deficiencies demonstrate at least partial reciprocal compensation 710431 3.4.18.1 additional information the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis, SOD1-G93A, and associated with plaques in transgenic mice expressing the human amyloid precursor protein APP containing the mutation K670M/N671L, overview 683448