3.4.23.48	D206A	1.3% of wild-type plasminogen activation	638924	
3.4.23.48	D206A	proteolytic activity is abolished	638923	
3.4.23.48	D206A	site-directed mutagenesis, introducing the single point mutation into the active site of Pla suffices to render fully virulent Yersinia pestis susceptible to primed T-cells. The protective capacity of YopE-specific CD8 T cells against CO92 Pla-D206A is abrogated in mice with low levels of tissue factor activity as well as in PAI-1/TAFI double knockout mice. In addition, YopE-specific CD8 T cells poorly protect wild-type mice treated with Coumadin, a pharmacologic anticoagulant that reduces production of fibrin	-, 753803	
3.4.23.48	D212R	111% of wild-type plasminogen activation	638924	
3.4.23.48	D84A	3.7% of wild-type plasminogen activation	638924	
3.4.23.48	D86A	3.5% of wild-type plasminogen activation	638924	
3.4.23.48	D86A	inactive, crystallization data	718407	
3.4.23.48	D97A	56% of wild-type plasminogen activation	638924	
3.4.23.48	E217S	52% of wild-type plasminogen activation	638924	
3.4.23.48	F215Y	42% of wild-type plasminogen activation	638924	
3.4.23.48	G178A/L179A	mutation decreases laminin binding in the YPYIPTL region	668991	
3.4.23.48	H101V	0.8% of wild-type plasminogen activation	638924	
3.4.23.48	H108V	121% of wild-type plasminogen activation	638924	
3.4.23.48	H203V	109% of wild-type plasminogen activation	638924	
3.4.23.48	H208V	1.7% of wild-type plasminogen activation	638924	
3.4.23.48	H28V	125% of wild-type plasminogen activation	638924	
3.4.23.48	H98V	94% of wild-type plasminogen activation	638924	
3.4.23.48	K218A	103% of wild-type plasminogen activation	638924	
3.4.23.48	K240A	151% of wild-type plasminogen activation	638924	
3.4.23.48	K249A	132% of wild-type plasminogen activation	638924	
3.4.23.48	K254A	90% of wild-type plasminogen activation	638924	
3.4.23.48	K262A	85% of wild-type plasminogen activation	638924	
3.4.23.48	K280A	98% of wild-type plasminogen activation	638924	
3.4.23.48	L213I	123% of wild-type plasminogen activation	638924	
3.4.23.48	L65A/T66A/L67A	mutation decreases laminin binding in the WSLLTPA region	668991	
3.4.23.48	M210G	58% of wild-type plasminogen activation	638924	
3.4.23.48	additional information	swapping of ten amino acid residues at two surface loops of Pla and membrane protease Epo of the plant pathogenic Erwinia pyrifoliae introduces plasminogen activation capacity in Epo and inactivates the function in Pla	717438	
3.4.23.48	additional information	the acyltransferase gene mutant lpxM has an altered activity of plasminogen activator Pla	713437	
3.4.23.48	additional information	the Pla I259T modification is not required to cause pneumonic plague in the murine intranasal model	755136	
3.4.23.48	R211K	11% of wild-type plasminogen activation	638924	
3.4.23.48	S267A	108% of wild-type plasminogen activation	638924	
3.4.23.48	S77A	133% of wild-type plasminogen activation	638924	
3.4.23.48	S99A	1% of wild-type plasminogen activation	638924	
3.4.23.48	S99A	proteolytic activity is abolished	638923	
3.4.23.48	T259I	the substitution impairs fibrinolytic activity and plasminogen activation	712282