1.14.17.1 A318S site-directed mutagenesis, the enzyme shows a marginal decrease in homospecific activity 745892 1.14.17.1 A318S the mutation does not influence enzyme activity 728562 1.14.17.1 A348E retained inside cell in a premature endoplasmic reticulum form, also naturally occuring mutation 715661 1.14.17.1 C1021T naturally occuring gene polymorphism, determination of the frequency in combat veterans with or without chronic posttraumatic stress disorder, overview 684300 1.14.17.1 D100E retained inside cell in a premature endoplasmic reticulum form, also naturally occuring mutation 715661 1.14.17.1 D331N retained inside cell in a premature endoplasmic reticulum form, also naturally occuring mutation 715661 1.14.17.1 D460N site-directed mutagenesis, the mutant shows reduced expression levels compared to the wild-type enzyme, the mutant shows reduced expression levels compared to the wild-type enzyme 745892 1.14.17.1 G482R the mutation has subsequent effect on the activity of the enzyme as it is present close to the active site 728562 1.14.17.1 L208F a natural variant - three phenotypes of enzyme isolated: 4 * L208-homoenzyme, 4 * F208-homoenzyme and 2 * F208, 2 * L208-heteroenzyme, no significant difference in kinetic properties 438634 1.14.17.1 L317P site-directed mutagenesis, the mutant shows secretory deficiency and is localized in the endoplasmic reticulum 745892 1.14.17.1 L317P the mutation does not influence enzyme activity 728562 1.14.17.1 additional information construction of chimera: dopamine-betamonooxygenase signal, residue 1-42 appended to peptidylglycine alpha-hydroxylating monoxygenase, result: the signal/anchor domain of enzyme is responsible for its membrane association and is likely to play a key role in the targeting of enzyme to secretory garnules in chromaffin cells and adrenergic neurons 438638 1.14.17.1 additional information correlation of plasma dopamine beta-hydroxylase activity with polymorphisms in DBH gene in Eastern Indian population, genotyping, allele frequencies and effects of haplotypes, overview 686029 1.14.17.1 additional information genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans, genotyping, relationship between DBH polymorphisms and pDbetaH in samples, overview 686516 1.14.17.1 additional information LvDBH expression is silenced in thoracic ganglia, haemocytes and hepatopancreas of shrimp by treatment with LvDBH-dsRNA for 3 days, a decrease of DBH contents in haemocytes accompanied by decreased levels of norepinephrine and dopamine in hemolymph are observed 744949 1.14.17.1 R549C site-directed mutagenesis, the enzyme shows a marginal decrease in homospecific activity, the mutant shows partial secretory deficiency and is localized in the endoplasmic reticulum 745892 1.14.17.1 R549C the mutation causes abnormal oligomerization through non-native disulfide bond formation 728562 1.14.17.1 W544S site-directed mutagenesis, the enzyme shows a marginal decrease in homospecific activity, the mutant shows reduced expression levels compared to the wild-type enzyme 745892