3.1.4.53	3',5'-cyclic-amp phosphodiesterase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213210&form=6&db=m	Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.	causal interaction,therapeutic application,unassigned	4,4,0	
3.1.4.53	3',5'-cyclic-amp phosphodiesterase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19359377&form=6&db=m	Reduced adiposity and high fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B.	causal interaction,therapeutic application,unassigned	4,4,0	
3.1.4.53	3',5'-cyclic-amp phosphodiesterase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25457552&form=6&db=m	Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.	ongoing research,unassigned	4,0	
3.1.4.53	3',5'-cyclic-amp phosphodiesterase deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32264695&form=6&db=m	Cardiac Overexpression of PDE4B Blunts ?-Adrenergic Response and Maladaptive Remodeling in Heart Failure.	causal interaction,therapeutic application,unassigned	4,4,0	
3.1.4.53	Acquired Immunodeficiency Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31231579&form=6&db=m	Novel GFP-fused protein probes for detecting phosphatidylinositol-4-phosphate in the plasma membrane.	unassigned	-	
3.1.4.53	Acute Kidney Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32622666&form=6&db=m	Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy.	therapeutic application,unassigned	1,0	
3.1.4.53	Acute Lung Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9490659&form=6&db=m	Suppression of acute lung injury in mice by an inhibitor of phosphodiesterase type 4.	ongoing research,therapeutic application,unassigned	3,4,0	
3.1.4.53	Acute Lung Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10806144&form=6&db=m	Additive effects of phosphodiesterase-4 inhibition on effects of rSP-C surfactant.	ongoing research,therapeutic application,unassigned	3,4,0	
3.1.4.53	Acute Lung Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11907182&form=6&db=m	The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-beta release during acute lung injury in mice: the role of the balance between Tumor necrosis factor-alpha and interleukin-10.	causal interaction,therapeutic application,unassigned	3,1,0	
3.1.4.53	Acute Lung Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882446&form=6&db=m	Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,3,4