3.4.22.55	Acrocephalosyndactylia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854168&form=6&db=m	Twist haploinsufficiency in Saethre-Chotzen syndrome induces calvarial osteoblast apoptosis due to increased TNFalpha expression and caspase-2 activation.	causal interaction,unassigned	2,0	
3.4.22.55	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25010987&form=6&db=m	Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.	causal interaction,ongoing research,unassigned	1,3,0	
3.4.22.55	Adenocarcinoma of Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15941563&form=6&db=m	Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.	ongoing research,therapeutic application,unassigned	4,2,0	
3.4.22.55	Adenocarcinoma of Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18375382&form=6&db=m	c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.	diagnostic usage,ongoing research,unassigned	1,4,0	
3.4.22.55	Adenoma, Pleomorphic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27981346&form=6&db=m	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.	diagnostic usage,ongoing research,unassigned	3,1,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9507158&form=6&db=m	Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.	causal interaction,therapeutic application,unassigned	2,1,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10079193&form=6&db=m	Changes in caspase expression in Alzheimer's disease: comparison with development and aging.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,2,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23748737&form=6&db=m	Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.	causal interaction,therapeutic application,unassigned	4,4,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27901073&form=6&db=m	THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer's Disease.	causal interaction,unassigned	4,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31362787&form=6&db=m	A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.	causal interaction,unassigned	3,0