3.4.22.55	Acrocephalosyndactylia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854168&form=6&db=m	Twist haploinsufficiency in Saethre-Chotzen syndrome induces calvarial osteoblast apoptosis due to increased TNFalpha expression and caspase-2 activation.	causal interaction,unassigned	2,0	
3.4.22.55	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25010987&form=6&db=m	Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.	causal interaction,ongoing research,unassigned	1,3,0	
3.4.22.55	Adenocarcinoma of Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15941563&form=6&db=m	Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.	ongoing research,therapeutic application,unassigned	4,2,0	
3.4.22.55	Adenocarcinoma of Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18375382&form=6&db=m	c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.	diagnostic usage,ongoing research,unassigned	1,4,0	
3.4.22.55	Adenoma, Pleomorphic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27981346&form=6&db=m	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.	diagnostic usage,ongoing research,unassigned	3,1,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9507158&form=6&db=m	Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.	causal interaction,therapeutic application,unassigned	2,1,0	
3.4.22.55	Amyloidosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28389707&form=6&db=m	The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.	therapeutic application,unassigned	2,0	
3.4.22.55	Astrocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12761355&form=6&db=m	A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells.	ongoing research,therapeutic application,unassigned	2,2,0	
3.4.22.55	Ataxia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11536012&form=6&db=m	Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.	causal interaction,unassigned	1,0	
3.4.22.55	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24309929&form=6&db=m	Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.	ongoing research,unassigned	1,0