3.4.22.53	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217905&form=6&db=m	1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours.	causal interaction,diagnostic usage,ongoing research,unassigned	3,2,1,0	
3.4.22.53	Wolfram Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422446&form=6&db=m	A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,4,0	
3.4.22.53	Starvation	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055788&form=6&db=m	A key role for calpains in retinal ganglion cell death.	causal interaction,therapeutic application,unassigned	1,1,0	
3.4.22.53	Hypertension	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26248159&form=6&db=m	Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,2,0	
3.4.22.53	Pulmonary Arterial Hypertension	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26248159&form=6&db=m	Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.	causal interaction,diagnostic usage,therapeutic application,unassigned	4,3,2,0	
3.4.22.53	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9296555&form=6&db=m	Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.	causal interaction,ongoing research,unassigned	3,1,0	
3.4.22.53	Cataract	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2998702&form=6&db=m	Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
3.4.22.53	Cataract	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395520&form=6&db=m	alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract.	ongoing research,unassigned	3,0	
3.4.22.53	Muscular Dystrophy, Duchenne	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16815350&form=6&db=m	Altered expression, intracellular distribution and activity of lymphocyte calpain II in Duchenne muscular dystrophy.	diagnostic usage,ongoing research,unassigned	3,3,0	
3.4.22.53	Cataract	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848210&form=6&db=m	Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64.	causal interaction,ongoing research,therapeutic application,unassigned	4,2,4,0