3.4.22.53	Acidosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19251930&form=6&db=m	Influence of glutamine infusion on ubiquitin, caspase-3, cathepsins L and B, and m-calpain expression in sheep with nutritionally induced metabolic acidosis.	ongoing research,unassigned	1,0	
3.4.22.53	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466976&form=6&db=m	Overexpression of m-calpain in human colorectal adenocarcinomas.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,4,1	
3.4.22.53	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23329366&form=6&db=m	Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,4,1	
3.4.22.53	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718565&form=6&db=m	Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,1,3,1	
3.4.22.53	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2072120&form=6&db=m	Comparison of Ca(2+)-activated proteinase enzyme and endogenous inhibitor activity in brain tissue from normal and Alzheimer's disease cases.	diagnostic usage,ongoing research,unassigned	3,4,0	
3.4.22.53	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9296555&form=6&db=m	Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.	causal interaction,ongoing research,unassigned	3,1,0	
3.4.22.53	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9654354&form=6&db=m	m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,1,0	
3.4.22.53	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m	The calpain family and human disease.	causal interaction,diagnostic usage,unassigned	4,1,0	
3.4.22.53	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m	Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,2,2,2	
3.4.22.53	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23889979&form=6&db=m	Hypoxia-Triggered m-Calpain Activation Evokes Endoplasmic Reticulum Stress and Neuropathogenesis in a Transgenic Mouse Model of Alzheimer's Disease.	ongoing research,unassigned	2,0