3.4.22.49	Blast Crisis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26087013&form=6&db=m	Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.	causal interaction,therapeutic application,unassigned	1,2,0	
3.4.22.49	Blast Crisis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26937281&form=6&db=m	c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.49	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18728194&form=6&db=m	Overexpression of Separase induces aneuploidy and mammary tumorigenesis.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
3.4.22.49	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19008095&form=6&db=m	Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study.	diagnostic usage,ongoing research,unassigned	4,3,0	
3.4.22.49	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24276237&form=6&db=m	MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.	causal interaction,diagnostic usage,unassigned	4,1,0	
3.4.22.49	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24481326&form=6&db=m	Genetically engineered ER? positive breast cancer mouse models.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,1,3,0	
3.4.22.49	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25086634&form=6&db=m	ESPL1 is a candidate oncogene of luminal B breast cancers.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,2,4	
3.4.22.49	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28177203&form=6&db=m	Biology and insights into the role of cohesin protease separase in human malignancies.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,3,4,1	
3.4.22.49	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28859055&form=6&db=m	Separase is a marker for prognosis and mitotic activity in breast cancer.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,1,1	
3.4.22.49	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29780443&form=6&db=m	Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.	ongoing research,therapeutic application,unassigned	1,1,0