6.1.1.4 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20194621&form=6&db=m Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes. causal interaction,unassigned 2,0 6.1.1.4 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26537577&form=6&db=m LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. causal interaction,unassigned 2,0 6.1.1.4 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28847973&form=6&db=m Correction for Li and Guan, "Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNA(Leu(UUR)) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes". causal interaction,unassigned 1,0 6.1.1.4 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442335&form=6&db=m The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 6.1.1.4 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300650&form=6&db=m Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations. causal interaction,therapeutic application,unassigned 4,1,0 6.1.1.4 Anemia, Sideroblastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26537577&form=6&db=m LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. causal interaction,unassigned 2,0 6.1.1.4 Anemia, Sideroblastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442335&form=6&db=m The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 6.1.1.4 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446061&form=6&db=m Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 6.1.1.4 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19129950&form=6&db=m Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 6.1.1.4 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31205503&form=6&db=m Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer. ongoing research,therapeutic application,unassigned 3,4,0 6.1.1.4 CHARGE Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263850&form=6&db=m Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea. diagnostic usage,unassigned 2,0 6.1.1.4 Coma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23470551&form=6&db=m Prognostic value of time-related Glasgow Coma Scale components in severe traumatic brain injury: a prospective evaluation with respect to 1-year survival and functional outcome. ongoing research,unassigned 1,0 6.1.1.4 Confusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16500825&form=6&db=m Homosexuality in ancient and modern Korea. unassigned - 6.1.1.4 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249208&form=6&db=m Instagram as a virtual art display for medical students. unassigned - 6.1.1.4 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27623246&form=6&db=m Characterization of a knock-in mouse model of the homozygous p.V37I variant in Gjb2. unassigned - 6.1.1.4 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737337&form=6&db=m Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 6.1.1.4 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31767665&form=6&db=m Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy. unassigned - 6.1.1.4 Deafness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442335&form=6&db=m The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 6.1.1.4 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15919814&form=6&db=m Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 6.1.1.4 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19847392&form=6&db=m Genetic association analysis of LARS2 with type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 6.1.1.4 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300650&form=6&db=m Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations. causal interaction,therapeutic application,unassigned 4,1,0 6.1.1.4 Gram-Negative Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625818&form=6&db=m An assessment of the genetic toxicology of novel boron-containing therapeutic agents. causal interaction,therapeutic application,unassigned 3,4,0 6.1.1.4 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23541342&form=6&db=m Mutations in LARS2, Encoding Mitochondrial Leucyl-tRNA Synthetase, Lead to Premature Ovarian Failure and Hearing Loss in Perrault Syndrome. causal interaction,unassigned 1,0 6.1.1.4 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26537577&form=6&db=m LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. causal interaction,unassigned 2,0 6.1.1.4 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263850&form=6&db=m Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea. diagnostic usage,unassigned 2,0 6.1.1.4 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442335&form=6&db=m The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 6.1.1.4 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32842620&form=6&db=m Novel Mutations in CLPP, LARS2, CDH23, and COL4A5 Identified in Familial Cases of Prelingual Hearing Loss. causal interaction,unassigned 2,0 6.1.1.4 Hearing Loss, Sensorineural http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28832386&form=6&db=m Marfanoid habitus is a nonspecific feature of Perrault syndrome. unassigned - 6.1.1.4 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33884191&form=6&db=m Prevalence and perinatal outcomes of non-communicable diseases in pregnancy in a regional hospital in Haiti: A prospective cohort study. ongoing research,unassigned 2,0 6.1.1.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23959225&form=6&db=m Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase. causal interaction,therapeutic application,unassigned 3,4,0 6.1.1.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25348524&form=6&db=m Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. causal interaction,therapeutic application,unassigned 2,4,0 6.1.1.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534653&form=6&db=m Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents. causal interaction,therapeutic application,unassigned 3,4,0 6.1.1.4 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33308792&form=6&db=m Directive clinique no 409 : Tests diagnostiques fœtaux intra-utérins en cas d'infection virale chronique maternelle. unassigned - 6.1.1.4 Kallmann Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263850&form=6&db=m Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea. diagnostic usage,unassigned 2,0 6.1.1.4 leucine-trna ligase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33863987&form=6&db=m Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish. causal interaction,unassigned 4,0 6.1.1.4 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28774368&form=6&db=m [Clinical feature and molecular diagnostic analysis of the first non-caucasian child with infantile liver failure syndrome type 1]. causal interaction,unassigned 3,0 6.1.1.4 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32699352&form=6&db=m Genotypic diversity and phenotypic spectrum of infantile liver failure syndrome type 1 due to variants in LARS1. causal interaction,unassigned 1,0 6.1.1.4 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300650&form=6&db=m Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations. causal interaction,therapeutic application,unassigned 4,1,0 6.1.1.4 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33314043&form=6&db=m Infantile Liver Failure Syndrome 1 associated with a novel variant of the LARS1 gene: Clinical, genetic, and functional characterization. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 6.1.1.4 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34496286&form=6&db=m Deep phenotyping of MARS1 (interstitial lung and liver disease) and LARS1 (infantile liver failure syndrome 1) recessive multisystemic disease using Human Phenotype Ontology annotation: Overlap and differences. Case report and review of literature. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 6.1.1.4 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300650&form=6&db=m Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations. causal interaction,therapeutic application,unassigned 4,1,0 6.1.1.4 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33558292&form=6&db=m A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity. causal interaction,therapeutic application,unassigned 2,4,0 6.1.1.4 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446061&form=6&db=m Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 6.1.1.4 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31205503&form=6&db=m Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer. ongoing research,therapeutic application,unassigned 3,4,0 6.1.1.4 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534653&form=6&db=m Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents. causal interaction,therapeutic application,unassigned 3,4,0 6.1.1.4 Mandibulofacial Dysostosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263850&form=6&db=m Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea. diagnostic usage,unassigned 2,0 6.1.1.4 MELAS Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21724600&form=6&db=m Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria. ongoing research,unassigned 4,0 6.1.1.4 MELAS Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34357047&form=6&db=m Exploring the Ability of LARS2 Carboxy-Terminal Domain in Rescuing the MELAS Phenotype. unassigned - 6.1.1.4 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3517238&form=6&db=m Samuel Auguste Tissot (1728-1797). His research on migraine. unassigned - 6.1.1.4 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737337&form=6&db=m Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 6.1.1.4 Mitochondrial Encephalomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20194621&form=6&db=m Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes. causal interaction,unassigned 2,0 6.1.1.4 Mitochondrial Encephalomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28847973&form=6&db=m Correction for Li and Guan, "Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNA(Leu(UUR)) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes". causal interaction,unassigned 1,0 6.1.1.4 Mitochondrial Myopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442335&form=6&db=m The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 6.1.1.4 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442335&form=6&db=m The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 6.1.1.4 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534653&form=6&db=m Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents. causal interaction,therapeutic application,unassigned 3,4,0 6.1.1.4 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19129950&form=6&db=m Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 6.1.1.4 Nasopharyngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19129950&form=6&db=m Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446061&form=6&db=m Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23361008&form=6&db=m Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase. therapeutic application,unassigned 3,0 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27239038&form=6&db=m An In Vivo Gain-of-Function Screen Identifies the Williams-Beuren Syndrome Gene GTF2IRD1 as a Mammary Tumor Promoter. unassigned - 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31148683&form=6&db=m Degrés de collaboration perçus entre les patients atteints de cancer et leurs prestataires de soins pendant la radiothérapie. unassigned - 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33118994&form=6&db=m Avoir sa santé en main : le sentiment d'habilitation tel que perçu par les jeunes adultes souffrant d'un cancer avancé. unassigned - 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33118997&form=6&db=m Retour au travail de patients atteints de cancer. unassigned - 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33119728&form=6&db=m Élaboration d'un énoncé de position national sur la navigation des patients atteints de cancer au Canada. unassigned - 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34325132&form=6&db=m Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells. causal interaction,therapeutic application,unassigned 4,3,0 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395832&form=6&db=m Connaissances, attitudes et croyances concernant le dépistage du cancer du col utérin dans le District d'Ajumako-Enyan-Essiam au Ghana. unassigned - 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395836&form=6&db=m Concept d'adaptation chez les conjoints de femmes iraniennes atteintes du cancer du sein: étude qualitative basée sur une approche phénoménologique. unassigned - 6.1.1.4 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395844&form=6&db=m Optimiser les soins des adultes âgés atteints de cancer et l'accompagnement de leurs proches: énoncé de position et contribution des infirmières canadiennes en oncologie. unassigned - 6.1.1.4 Nephritis, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263850&form=6&db=m Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea. diagnostic usage,unassigned 2,0 6.1.1.4 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29205794&form=6&db=m Biallelic mutations in LARS2 can cause Perrault syndrome type 2 with neurologic symptoms. causal interaction,unassigned 3,0 6.1.1.4 Onychomycosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17588934&form=6&db=m An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. therapeutic application,unassigned 3,0 6.1.1.4 Pediatric Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26482219&form=6&db=m Prendre le virage des partenariats. unassigned - 6.1.1.4 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23541342&form=6&db=m Mutations in LARS2, Encoding Mitochondrial Leucyl-tRNA Synthetase, Lead to Premature Ovarian Failure and Hearing Loss in Perrault Syndrome. causal interaction,unassigned 1,0 6.1.1.4 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26537577&form=6&db=m LARS2 Variants Associated with Hydrops, Lactic Acidosis, Sideroblastic Anemia, and Multisystem Failure. causal interaction,unassigned 2,0 6.1.1.4 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28832386&form=6&db=m Marfanoid habitus is a nonspecific feature of Perrault syndrome. unassigned - 6.1.1.4 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737337&form=6&db=m Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 6.1.1.4 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442335&form=6&db=m The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 6.1.1.4 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21563216&form=6&db=m Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutation. diagnostic usage,ongoing research,unassigned 4,1,0 6.1.1.4 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2015274&form=6&db=m Yeast proteinase yscB inactivates the leucyl tRNA synthetase in extracts of Saccharomyces cerevisiae. ongoing research,unassigned 1,0 6.1.1.4 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2532300&form=6&db=m Regulation of the nuclear genes encoding the cytoplasmic and mitochondrial leucyl-tRNA synthetases of Neurospora crassa. causal interaction,unassigned 4,0 6.1.1.4 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7680341&form=6&db=m In vivo regulatory responses of four Escherichia coli operons which encode leucyl-tRNAs. unassigned - 6.1.1.4 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8439330&form=6&db=m Membrane association of leucyl-tRNA synthetase during leucine starvation in Escherichia coli. ongoing research,therapeutic application,unassigned 2,2,0 6.1.1.4 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24710704&form=6&db=m Mitochondrial leucine tRNA level and PTCD1 are regulated in response to leucine starvation. causal interaction,unassigned 2,0 6.1.1.4 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31780625&form=6&db=m Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1. unassigned - 6.1.1.4 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32023445&form=6&db=m Glucose Starvation Blocks Translation at Multiple Levels. unassigned - 6.1.1.4 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29614877&form=6&db=m A video-game group intervention: Experiences and perceptions of adults with chronic stroke and their therapists: Intervention de groupe à l'aide de jeux vidéo : Expériences et perceptions d'adultes en phase chronique d'un accident vasculaire cérébral et de leurs ergothérapeutes. ongoing research,unassigned 1,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11087829&form=6&db=m A prokaryote and human tRNA synthetase provide an essential RNA splicing function in yeast mitochondria. ongoing research,unassigned 2,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23268443&form=6&db=m Crucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing. ongoing research,unassigned 4,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26822568&form=6&db=m Discovery of potent anti-tuberculosis agents targeting leucyl-tRNA synthetase. therapeutic application,unassigned 1,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27241561&form=6&db=m Identification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one. causal interaction,therapeutic application,unassigned 2,4,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27503647&form=6&db=m Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28953378&form=6&db=m Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31182528&form=6&db=m First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment. diagnostic usage,therapeutic application,unassigned 2,3,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31691918&form=6&db=m Dual-targeted hit identification using pharmacophore screening. ongoing research,therapeutic application,unassigned 2,1,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31791947&form=6&db=m In Vitro Susceptibility Testing of GSK656 against Mycobacterium Species. therapeutic application,unassigned 1,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32206244&form=6&db=m Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N'-thiazol-2-yl-hydrazines. ongoing research,therapeutic application,unassigned 1,2,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33558292&form=6&db=m A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Anti-Mycobacterial Activity. causal interaction,therapeutic application,unassigned 2,4,0 6.1.1.4 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33785838&form=6&db=m Discovery of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazole derivatives targeting aminoacyl-tRNA synthetases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 6.1.1.4 Urinary Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25348524&form=6&db=m Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. causal interaction,therapeutic application,unassigned 2,4,0 6.1.1.4 Usher Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263850&form=6&db=m Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea. diagnostic usage,unassigned 2,0 6.1.1.4 Waardenburg Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263850&form=6&db=m Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea. diagnostic usage,unassigned 2,0