4.4.1.20 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7613129&form=6&db=m The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase. unassigned - 4.4.1.20 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11319240&form=6&db=m Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase. ongoing research,unassigned 2,0 4.4.1.20 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21078989&form=6&db=m Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm. causal interaction,ongoing research,unassigned 3,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7937884&form=6&db=m Molecular cloning and expression of human leukotriene-C4 synthase. causal interaction,unassigned 2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8626689&form=6&db=m Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. unassigned - 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9466979&form=6&db=m Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. ongoing research,unassigned 1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10436863&form=6&db=m LTC4 synthase. Enzymology, biochemistry, and molecular characterization. causal interaction,unassigned 4,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10624490&form=6&db=m Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype. causal interaction,ongoing research,unassigned 4,2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10887308&form=6&db=m 5' flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States. unassigned - 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063521&form=6&db=m Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12360108&form=6&db=m Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma. causal interaction,ongoing research,unassigned 1,2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12534456&form=6&db=m Clinical and genetic features underlying the response of patients with bronchial asthma to treatment with a leukotriene receptor antagonist. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12728163&form=6&db=m Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma. causal interaction,ongoing research,unassigned 4,2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891383&form=6&db=m Promoter polymorphism influences the effect of dexamethasone on transcriptional activation of the LTC4 synthase gene. causal interaction,unassigned 4,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12968987&form=6&db=m Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma. causal interaction,unassigned 4,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14520724&form=6&db=m Effect of montelukast on time-course of exhaled nitric oxide in asthma: influence of LTC4 synthase A(-444)C polymorphism. causal interaction,ongoing research,unassigned 1,3,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561202&form=6&db=m Diagnosis, prevention and treatment of aspirin-induced asthma and rhinitis. causal interaction,therapeutic application,unassigned 3,4,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14749922&form=6&db=m Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. causal interaction,unassigned 2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15055561&form=6&db=m Leukotriene generation and clinical implications. unassigned - 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15131571&form=6&db=m Characterization of two polymorphisms in the leukotriene C4 synthase gene in an Australian population of subjects with mild, moderate, and severe asthma. unassigned - 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637573&form=6&db=m Uncertain biologic relevance of polymorphisms of leukotriene C4 synthase in asthma. diagnostic usage,unassigned 1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16024972&form=6&db=m Association of IL-13, RANTES, and leukotriene C4 synthase gene promoter polymorphisms with asthma and/or atopy in African Americans. diagnostic usage,ongoing research,unassigned 2,2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16340173&form=6&db=m Lack of an association between a newly identified promoter polymorphism (-1702G > A) of the leukotriene C4 synthase gene and aspirin-intolerant asthma in a Korean population. causal interaction,ongoing research,unassigned 3,2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16583357&form=6&db=m Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma. causal interaction,unassigned 1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16825866&form=6&db=m Genetic mechanism of aspirin-induced urticaria/angioedema. therapeutic application,unassigned 1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17063752&form=6&db=m Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17097040&form=6&db=m Association between leukotriene C4 synthase A-444C polymorphism and asthma in Chinese Han population in Beijing. unassigned - 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17153879&form=6&db=m Analysis of 927T> C CYSLTRI and -444A > C LTC4S polymorphisms in patients with asthma. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17641958&form=6&db=m Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity. ongoing research,unassigned 2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17672811&form=6&db=m Implications of pharmacogenomics in the current and future treatment of asthma. causal interaction,diagnostic usage,unassigned 1,2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19080797&form=6&db=m Analysis of 927T > C CYSLTR1 and -444A > C LTC4S polymorphisms in children with asthma. causal interaction,therapeutic application,unassigned 1,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280718&form=6&db=m Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19524426&form=6&db=m Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma. diagnostic usage,therapeutic application,unassigned 2,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19558806&form=6&db=m [Relationship between the efficacy of inhaled corticosteroids and the leukotriene expression in children with asthma] causal interaction,unassigned 4,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20128419&form=6&db=m 5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20980252&form=6&db=m Arginine 104 is a key catalytic residue in leukotriene C4 synthase. unassigned - 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21307858&form=6&db=m Polymorphisms of the PTGDR and LTC4S influence responsiveness to leukotriene receptor antagonists in Korean children with asthma. causal interaction,ongoing research,unassigned 3,2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22722751&form=6&db=m Association of the -1072G/A Polymorphism in the LTC4S Gene with Asthma in an Indian Population. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22884858&form=6&db=m The -444A/C Polymorphism in the LTC4S Gene and Risk of Asthma: Meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25485197&form=6&db=m LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27990118&form=6&db=m Cysteinyl Leukotrienes Pathway Genes, Atopic Asthma and Drug Response: From Population Isolates to Large Genome-Wide Association Studies. causal interaction,therapeutic application,unassigned 1,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28275397&form=6&db=m Association of Leukotriene C4 Synthase A-444C Polymorphism with Asthma and Asthma Phenotypes in Romanian Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400178&form=6&db=m Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review. causal interaction,unassigned 4,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28740106&form=6&db=m Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes. ongoing research,therapeutic application,unassigned 1,1,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29676619&form=6&db=m Cysteinyl Leukotriene Receptor 1 and Health Effects of Particulate Exposure in Asthma. ongoing research,unassigned 2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29749828&form=6&db=m Candidate gene analysis of asthma in a population of Arab descent: a case-control study in Jordan. diagnostic usage,unassigned 2,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31415176&form=6&db=m Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma. causal interaction,therapeutic application,unassigned 2,4,0 4.4.1.20 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32441366&form=6&db=m The synthesis of one H-2 labeled and two H-3 labeled leukotriene C4 synthase inhibitors. therapeutic application,unassigned 4,0 4.4.1.20 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393345&form=6&db=m Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma. diagnostic usage,unassigned 1,0 4.4.1.20 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10624490&form=6&db=m Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype. causal interaction,ongoing research,unassigned 4,2,0 4.4.1.20 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11240968&form=6&db=m Leukotriene C4 synthase polymorphism and aspirin-induced asthma. unassigned - 4.4.1.20 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11964666&form=6&db=m Aspirin-induced rhinitis and asthma. causal interaction,therapeutic application,unassigned 4,4,0 4.4.1.20 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063521&form=6&db=m Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 4.4.1.20 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505607&form=6&db=m Pathogenesis of nonsteroidal antiinflammatory drug-induced asthma. causal interaction,therapeutic application,unassigned 4,1,0 4.4.1.20 Asthma, Exercise-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16675353&form=6&db=m The leukotriene C4 synthase (A-444C) promoter polymorphism is associated with the severity of exercise-induced asthma in Korean children. causal interaction,unassigned 3,0 4.4.1.20 Asthma, Exercise-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17883728&form=6&db=m Responsiveness to montelukast is associated with bronchial hyperresponsiveness and total immunoglobulin E but not polymorphisms in the leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes in Korean children with exercise-induced asthma (EIA). unassigned - 4.4.1.20 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280718&form=6&db=m Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 4.4.1.20 Blast Crisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9674747&form=6&db=m Novel enzymatic abnormalities in AML and CML in blast crisis: elevated leucocyte leukotriene C4 synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate. unassigned - 4.4.1.20 Bronchial Hyperreactivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10436863&form=6&db=m LTC4 synthase. Enzymology, biochemistry, and molecular characterization. causal interaction,unassigned 4,0 4.4.1.20 Bronchial Hyperreactivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10591082&form=6&db=m The biochemical, molecular, and genomic aspects of leukotriene C4 synthase. unassigned - 4.4.1.20 Bronchitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28740106&form=6&db=m Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes. ongoing research,therapeutic application,unassigned 1,1,0 4.4.1.20 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280718&form=6&db=m Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 4.4.1.20 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20456754&form=6&db=m Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals. causal interaction,unassigned 4,0 4.4.1.20 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18276912&form=6&db=m Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease. causal interaction,therapeutic application,unassigned 4,1,0 4.4.1.20 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28740106&form=6&db=m Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes. ongoing research,therapeutic application,unassigned 1,1,0 4.4.1.20 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15510011&form=6&db=m Molecular and cellular staging for the severity of chronic rhinosinusitis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 4.4.1.20 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22777338&form=6&db=m Diagnostic Utility of Major Basic Protein, Eotaxin-3, and Leukotriene Enzyme Staining in Eosinophilic Esophagitis. diagnostic usage,therapeutic application,unassigned 4,1,0 4.4.1.20 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7827126&form=6&db=m Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. ongoing research,unassigned 3,0 4.4.1.20 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7853790&form=6&db=m Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. diagnostic usage,ongoing research,unassigned 2,2,0 4.4.1.20 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17571306&form=6&db=m [Gene expressions of LTC4 synthase homologs in Con A-induced mouse hepatitis and regulative effect of cyclosporine A] ongoing research,therapeutic application,unassigned 2,1,0 4.4.1.20 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25902778&form=6&db=m Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk. causal interaction,diagnostic usage,unassigned 4,2,0 4.4.1.20 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8111244&form=6&db=m Specific induction of LTC4 synthase by retinoic acid in rat basophilic leukemia-1 cells. causal interaction,unassigned 3,0 4.4.1.20 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280718&form=6&db=m Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 4.4.1.20 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280718&form=6&db=m Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 4.4.1.20 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25215090&form=6&db=m Association of ALOX5, LTA4H and LTC4S gene polymorphisms with ischemic stroke risk in a cohort of Chinese in east China. causal interaction,ongoing research,unassigned 4,2,0 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1517222&form=6&db=m Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells. ongoing research,unassigned 3,0 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833315&form=6&db=m Characterization of leukotriene C4 synthetase in mouse peritoneal exudate cells. ongoing research,unassigned 4,0 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3237082&form=6&db=m Leukotriene C4 synthase from rat basophilic leukemia cell microsomes. diagnostic usage,ongoing research,unassigned 1,4,0 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3866231&form=6&db=m Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells. diagnostic usage,ongoing research,unassigned 3,4,0 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6324687&form=6&db=m Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase. ongoing research,unassigned 4,0 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8203889&form=6&db=m Zinc and other divalent cations inhibit purified leukotriene A4 hydrolase and leukotriene B4 biosynthesis in human polymorphonuclear leukocytes. diagnostic usage,ongoing research,unassigned 1,3,0 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8425605&form=6&db=m Photoaffinity labelling of human leukotriene C4 synthase in THP-1 cell membranes. unassigned - 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630722&form=6&db=m Inhibition of leukotriene synthesis by azelastine. ongoing research,unassigned 4,0 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9295165&form=6&db=m Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells. diagnostic usage,ongoing research,unassigned 1,3,0 4.4.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767051&form=6&db=m Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone. diagnostic usage,ongoing research,unassigned 3,4,0 4.4.1.20 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1472015&form=6&db=m Induction of leukotriene C4 synthase activity in differentiating human erythroleukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 4.4.1.20 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591277&form=6&db=m Inverse relationship between myeloid maturation and leukotriene C4 synthase expression in normal and leukemic myelopoiesis-consistent overexpression of the enzyme in myeloid cells from patients with chronic myeloid leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 4.4.1.20 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15363129&form=6&db=m [Identification of acute leukemia-specific genes from leukemia recipient/sibling donor pairs by distinguishing study with oligonucleotide microarrays] diagnostic usage,therapeutic application,unassigned 3,1,0 4.4.1.20 Lung Diseases, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280718&form=6&db=m Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 4.4.1.20 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172733&form=6&db=m Leukotriene C4 synthase: characterization in mouse mastocytoma cells. ongoing research,unassigned 4,0 4.4.1.20 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9209681&form=6&db=m Human melanoma cells generate leukotrienes B4 and C4 from leukotriene A4. diagnostic usage,ongoing research,unassigned 3,4,0 4.4.1.20 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31867296&form=6&db=m Gene Polymorphism of Aspirin-Induced Urticaria in Children With Kawasaki Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 4.4.1.20 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280718&form=6&db=m Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 4.4.1.20 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400178&form=6&db=m Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review. causal interaction,unassigned 4,0 4.4.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19042113&form=6&db=m Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. causal interaction,unassigned 4,0 4.4.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26663781&form=6&db=m Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. causal interaction,therapeutic application,unassigned 2,1,0 4.4.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27017004&form=6&db=m Effect of lipopolysaccharide and cytokines on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs. ongoing research,unassigned 4,0 4.4.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28891085&form=6&db=m Lipopolysaccharide and cytokines modulate leukotriene (LT)B4 and LTC4 production by porcine endometrial endothelial cells. ongoing research,unassigned 4,0 4.4.1.20 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7853790&form=6&db=m Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. diagnostic usage,ongoing research,unassigned 2,2,0 4.4.1.20 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974812&form=6&db=m Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation. ongoing research,therapeutic application,unassigned 3,1,0 4.4.1.20 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280718&form=6&db=m Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 4.4.1.20 Pulmonary Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26342029&form=6&db=m Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. causal interaction,unassigned 2,0 4.4.1.20 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870346&form=6&db=m V-PYRRO/NO downregulates mRNA expression levels of leukotriene C4 synthase during hepatic ischemia reperfusion injury in rats via inhibition of the nuclear factor-?B activation pathway. causal interaction,unassigned 2,0 4.4.1.20 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28740106&form=6&db=m Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes. ongoing research,therapeutic application,unassigned 1,1,0 4.4.1.20 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16730545&form=6&db=m Leukotriene C4 synthase A-444C gene polymorphism in patients with allergic rhinitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 4.4.1.20 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400178&form=6&db=m Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review. causal interaction,unassigned 4,0 4.4.1.20 Sinusitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16675331&form=6&db=m Advances in upper airway diseases and allergen immunotherapy. unassigned - 4.4.1.20 Sinusitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17063752&form=6&db=m Expression of leukotriene C4 synthase and plasminogen activator inhibitor 1 gene promoter polymorphisms in sinusitis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 4.4.1.20 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15619010&form=6&db=m Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis. causal interaction,therapeutic application,unassigned 4,4,0 4.4.1.20 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16433794&form=6&db=m Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. causal interaction,unassigned 1,0 4.4.1.20 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19862937&form=6&db=m The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria. causal interaction,therapeutic application,unassigned 1,1,0 4.4.1.20 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31867296&form=6&db=m Gene Polymorphism of Aspirin-Induced Urticaria in Children With Kawasaki Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0