3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311239&form=6&db=m Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4). causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020478&form=6&db=m Aggrecanase-mediated cartilage degradation. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12755694&form=6&db=m Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters. causal interaction,unassigned 1,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880348&form=6&db=m ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17487981&form=6&db=m Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1). causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17546624&form=6&db=m Interleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19342688&form=6&db=m Adaptor proteins and Ras synergistically regulate IL-1-induced ADAMTS-4 expression in human chondrocytes. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26025392&form=6&db=m The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301579&form=6&db=m Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084617&form=6&db=m ADAMTS-4 in central nervous system pathologies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.82 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22324945&form=6&db=m Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.82 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17606262&form=6&db=m ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.82 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21334453&form=6&db=m The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-? and requires Smads, p38 mitogen-activated protein kinase and c-Jun. causal interaction,unassigned 4,0 3.4.24.82 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314835&form=6&db=m Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.82 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19944557&form=6&db=m ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.82 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21946608&form=6&db=m Association of serum a disintegrin and metalloproteinase with thrombospodin motif 4 levels with the presence and severity of coronary artery disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,3 3.4.24.82 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25592103&form=6&db=m A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.82 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11217446&form=6&db=m Tumor cell-matrix interaction: pericellular matrix degradation and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.82 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16133547&form=6&db=m Human glioblastomas overexpress ADAMTS-5 that degrades brevican. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.82 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664926&form=6&db=m Expression of ADAMTS4 in Ewing's sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31056878&form=6&db=m [Electroacupuncture down-regulates expression of ADAMTS-4 of intervertebral disc in rats with lumbar intervertebral disc degeneration]. causal interaction,unassigned 1,0 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31751427&form=6&db=m APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix. causal interaction,unassigned 2,0 3.4.24.82 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16741450&form=6&db=m Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1 3.4.24.82 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19944557&form=6&db=m ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.82 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21345877&form=6&db=m Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.4.24.82 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20006601&form=6&db=m ADAMTS-1 contributes to the antifibrotic effect of captopril by accelerating the degradation of type I collagen in chronic viral myocarditis. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16495931&form=6&db=m Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355265&form=6&db=m ADAMs in cancer cell proliferation and progression. causal interaction,unassigned 2,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260128&form=6&db=m Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664926&form=6&db=m Expression of ADAMTS4 in Ewing's sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21039798&form=6&db=m Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25693634&form=6&db=m CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25786261&form=6&db=m ADAMTS expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27707582&form=6&db=m Time-Dependent Effects of Arthroscopic Conditions on Human Articular Cartilage: An In Vivo Study. causal interaction,unassigned 3,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30623540&form=6&db=m Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34169995&form=6&db=m Role of Adamts-1 in Pleomorphic Xanthoastrocytoma Tumor Cells Progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16099106&form=6&db=m Aggrecanase-1 (ADAMTS-4) interacts with alpha1-antitrypsin. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17311924&form=6&db=m Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. causal interaction,unassigned 2,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17949675&form=6&db=m Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18671975&form=6&db=m Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19329309&form=6&db=m Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors. causal interaction,unassigned 3,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30016600&form=6&db=m Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5. causal interaction,unassigned 3,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30542428&form=6&db=m TNF-? increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655094&form=6&db=m The role of ADAMTS genes in the end stage of hip osteoarthritis. causal interaction,diagnostic usage,unassigned 2,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734379&form=6&db=m ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.82 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29086015&form=6&db=m The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.4.24.82 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301579&form=6&db=m Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.82 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084617&form=6&db=m ADAMTS-4 in central nervous system pathologies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19131116&form=6&db=m Cloning and expression of ADAM-related metalloproteases in equine laminitis. diagnostic usage,unassigned 3,0 3.4.24.82 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20625753&form=6&db=m Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.82 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29153440&form=6&db=m Relationship between ADAMTS4 and carotid atherosclerotic plaque vulnerability in humans. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.82 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29086015&form=6&db=m The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26686417&form=6&db=m The imbalance between TIMP3 and matrix-degrading enzymes plays an important role in intervertebral disc degeneration. diagnostic usage,unassigned 2,0 3.4.24.82 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23716507&form=6&db=m Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.82 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21257285&form=6&db=m The quantification of ADAMTS4 and 8 expression and selection of reference genes for quantitative real-time PCR analysis in myocardial infarction. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27359117&form=6&db=m Prognostic Value of ADAMTS Proteases and Their Substrates in Epithelial Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31415758&form=6&db=m Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15334469&form=6&db=m Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17968948&form=6&db=m Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501175&form=6&db=m Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31110568&form=6&db=m The Effect of Mesenchymal Stem Cell Wharton's Jelly on ADAMTS-4 and iNOS Levels in Osteoarthritis Rat Model. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.82 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27359117&form=6&db=m Prognostic Value of ADAMTS Proteases and Their Substrates in Epithelial Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.82 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33161094&form=6&db=m Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.82 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28417352&form=6&db=m Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome. diagnostic usage,unassigned 2,0 3.4.24.82 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30446843&form=6&db=m Abnormal expressions of ADAMTS-1, ADAMTS-9 and progesterone receptors are associated with lower oocyte maturation in women with polycystic ovary syndrome. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.82 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19944557&form=6&db=m ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.82 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27491335&form=6&db=m Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.82 Angina Pectoris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19944557&form=6&db=m ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.82 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17088949&form=6&db=m Expression of ADAMs and their inhibitors in sputum from patients with asthma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.4.24.82 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539621&form=6&db=m Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.82 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23859810&form=6&db=m Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: Differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.82 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25592103&form=6&db=m A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.82 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23289900&form=6&db=m Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.82 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23131589&form=6&db=m Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 3.4.24.82 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33352066&form=6&db=m ADAMTS proteases in cardiovascular physiology and disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,1 3.4.24.82 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25786261&form=6&db=m ADAMTS expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.82 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29694979&form=6&db=m Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.82 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32130380&form=6&db=m ADAMTS4 is upregulated in colorectal cancer and could be a useful prognostic indicator of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.24.82 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16303287&form=6&db=m Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.82 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16003758&form=6&db=m Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.82 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28803253&form=6&db=m Assessing Serum Levels of ADAMTS1 and ADAMTS4 as New Biomarkers for Patients with Type A Acute Aortic Dissection. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.82 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16630594&form=6&db=m ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.82 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27844209&form=6&db=m The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16741450&form=6&db=m Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23396662&form=6&db=m Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration. ongoing research,unassigned 2,0 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23778376&form=6&db=m Assessment of the Matrix Degenerative Effects of MMP-3, ADAMTS-4 and HTRA1 injected into a bovine Intervertebral Disc Organ Culture Model. ongoing research,unassigned 3,0 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31251999&form=6&db=m Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.82 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16495931&form=6&db=m Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.4.24.82 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17009305&form=6&db=m Role of aggrecanase 1 in Lyme arthritis. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996435&form=6&db=m High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells. ongoing research,unassigned 3,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194513&form=6&db=m The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15883123&form=6&db=m Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010931&form=6&db=m ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22324945&form=6&db=m Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126638&form=6&db=m Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.82 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22406378&form=6&db=m Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.82 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501175&form=6&db=m Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.4.24.82 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786374&form=6&db=m [EXPERIMENTAL STUDY ON LENTIVIRUS-MEDIATED MULTI-GENES CO-TRANSFECTION IN BONE MARROW MESENCHYMAL STEM CELLS FOR TREATMENT OF KNEE OSTEOARTHRITIS IN CYNOMOLGUS MONKEY]. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.82 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067610&form=6&db=m Expression Levels of A disintegrin-like metalloproteinase with thrombospondin motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in inflamed and healthy gingival tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 3.4.24.82 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32067610&form=6&db=m Expression Levels of A disintegrin-like metalloproteinase with thrombospondin motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in inflamed and healthy gingival tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 3.4.24.82 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27908842&form=6&db=m Role of Versican and ADAMTS-1 in Polycystic Ovary Syndrome. ongoing research,unassigned 1,0 3.4.24.82 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664926&form=6&db=m Expression of ADAMTS4 in Ewing's sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.82 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23131589&form=6&db=m Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1 3.4.24.82 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19944557&form=6&db=m ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.82 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20652528&form=6&db=m ADAMTS proteases: key roles in atherosclerosis? causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.82 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27491335&form=6&db=m Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.82 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28099917&form=6&db=m Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.82 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301579&form=6&db=m Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30468453&form=6&db=m Interleukin-1? exacerbates the catabolic effects of human nucleus pulposus cells through activation of the Nuclear Factor kappa B signaling pathway under hypoxic conditions. therapeutic application,unassigned 1,0 3.4.24.82 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12202483&form=6&db=m Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.82 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17470431&form=6&db=m TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4. therapeutic application,unassigned 1,0 3.4.24.82 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23295731&form=6&db=m The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.82 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734379&form=6&db=m ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.82 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18070483&form=6&db=m [Association between myocardial ADAMTS-1 expression and myocardial fibrosis in a murine model of viral myocarditis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26148557&form=6&db=m Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells. therapeutic application,unassigned 1,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29694979&form=6&db=m Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32130380&form=6&db=m ADAMTS4 is upregulated in colorectal cancer and could be a useful prognostic indicator of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19684582&form=6&db=m Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20652528&form=6&db=m ADAMTS proteases: key roles in atherosclerosis? causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23295731&form=6&db=m The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25606593&form=6&db=m Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25800415&form=6&db=m Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25909781&form=6&db=m The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26124002&form=6&db=m Characterization of neopeptides in equine articular cartilage degradation. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26288689&form=6&db=m Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT). causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26612259&form=6&db=m Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2). causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26813685&form=6&db=m Identification of Potent Virtual Leads Specific to S1' Loop of ADAMTS4: Pharmacophore Modeling, 3D-QSAR, Molecular Docking and Dynamic Studies. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27449198&form=6&db=m Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1? and Fibronectin and Contribution to Cartilage Damage. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27477461&form=6&db=m Computational Insights into ADAMTS4, ADAMTS5 and MMP13 Inhibitor Selectivity. causal interaction,therapeutic application,unassigned 3,2,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27706574&form=6&db=m Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30536194&form=6&db=m The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritis. diagnostic usage,therapeutic application,unassigned 4,1,0 3.4.24.82 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27706574&form=6&db=m Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.82 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22420304&form=6&db=m The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0 3.4.24.82 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24576594&form=6&db=m tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury. therapeutic application,unassigned 1,0 3.4.24.82 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25101296&form=6&db=m ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.82 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28829887&form=6&db=m Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis. ongoing research,therapeutic application,unassigned 3,3,0 3.4.24.82 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31010360&form=6&db=m Decreased ADAMTS-1, -9 and -20 levels in women with endometrial polyps: a possible link between extracellular matrix proteases and endometrial pathologies diagnostic usage,unassigned 4,0 3.4.24.82 Abscess http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31063202&form=6&db=m Histopathologic and immunohistochemical investigations of abscess fluid cells formed in the palato-gingival area. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.82 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20625753&form=6&db=m Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.82 adamts-4 endopeptidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28955046&form=6&db=m Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.82 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084617&form=6&db=m ADAMTS-4 in central nervous system pathologies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.82 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30426203&form=6&db=m The metalloprotease ADAMTS4 generates N-truncated A?4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.82 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26809777&form=6&db=m ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. ongoing research,unassigned 4,0 3.4.24.82 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26858022&form=6&db=m Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. ongoing research,unassigned 2,0 3.4.24.82 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084617&form=6&db=m ADAMTS-4 in central nervous system pathologies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.82 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28955046&form=6&db=m Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.82 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30979845&form=6&db=m Genetic correlates of wall shear stress in a patient-specific 3D-printed cerebral aneurysm model. unassigned - 3.4.24.82 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28803253&form=6&db=m Assessing Serum Levels of ADAMTS1 and ADAMTS4 as New Biomarkers for Patients with Type A Acute Aortic Dissection. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.82 Angina, Stable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21345877&form=6&db=m Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.4.24.82 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28955046&form=6&db=m Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.82 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28570682&form=6&db=m ADAMTS-1 in abdominal aortic aneurysm. causal interaction,unassigned 2,0 3.4.24.82 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32469162&form=6&db=m MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression. unassigned - 3.4.24.82 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23245439&form=6&db=m ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.82 Aortic Rupture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28955046&form=6&db=m Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.82 Arteriovenous Fistula http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20598569&form=6&db=m Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.82 Arteriovenous Fistula http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24732590&form=6&db=m Adventitial delivery of lentivirus-shRNA-ADAMTS-1 reduces venous stenosis formation in arteriovenous fistula. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10827174&form=6&db=m The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. unassigned - 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18247274&form=6&db=m ADAMTS-5: the story so far. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.82 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319426&form=6&db=m ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.82 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534304&form=6&db=m Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. causal interaction,unassigned 4,0 3.4.24.82 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161923&form=6&db=m ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. unassigned - 3.4.24.82 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16099106&form=6&db=m Aggrecanase-1 (ADAMTS-4) interacts with alpha1-antitrypsin. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.82 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23137648&form=6&db=m The low binding affinity of ADAMTS4 for citrullinated fibronectin may contribute to the destruction of joint cartilage in rheumatoid arthritis. causal interaction,unassigned 2,0 3.4.24.82 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25606593&form=6&db=m Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.82 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26813685&form=6&db=m Identification of Potent Virtual Leads Specific to S1' Loop of ADAMTS4: Pharmacophore Modeling, 3D-QSAR, Molecular Docking and Dynamic Studies. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.82 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152005&form=6&db=m The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship. diagnostic usage,therapeutic application,unassigned 3,1,0 3.4.24.82 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31063202&form=6&db=m Histopathologic and immunohistochemical investigations of abscess fluid cells formed in the palato-gingival area. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.82 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16630594&form=6&db=m ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.82 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301579&form=6&db=m Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.82 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14505115&form=6&db=m Proteases in brain tumour progression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.82 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15073121&form=6&db=m Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.24.82 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25998153&form=6&db=m miR?365 overexpression promotes cell proliferation and invasion by targeting ADAMTS-1 in breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.82 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29926003&form=6&db=m Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.82 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735305&form=6&db=m Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.82 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314835&form=6&db=m Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.82 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29926003&form=6&db=m Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.82 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27844209&form=6&db=m The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.82 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29086015&form=6&db=m The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.4.24.82 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30187439&form=6&db=m The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.82 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26809777&form=6&db=m ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. ongoing research,unassigned 4,0 3.4.24.82 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084617&form=6&db=m ADAMTS-4 in central nervous system pathologies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.82 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11068207&form=6&db=m Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions. ongoing research,unassigned 2,0 3.4.24.82 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11796708&form=6&db=m Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.82 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14701864&form=6&db=m ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. ongoing research,unassigned 1,0 3.4.24.82 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15736455&form=6&db=m Correlation between the histological grade of chondrosarcoma and the expression of MMPs, ADAMTSs and TIMPs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.82 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27070563&form=6&db=m Carnosol and Related Substances Modulate Chemokine and Cytokine Production in Macrophages and Chondrocytes. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.24.82 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27292772&form=6&db=m Functional roles of CSPG4/NG2 in chondrosarcoma. ongoing research,unassigned 1,0 3.4.24.82 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10811842&form=6&db=m ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function. ongoing research,unassigned 2,0 3.4.24.82 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18322241&form=6&db=m Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression. therapeutic application,unassigned 4,0 3.4.24.82 Coronary Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20625753&form=6&db=m Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.82 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30623540&form=6&db=m Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.82 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661359&form=6&db=m Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease. causal interaction,unassigned 3,0 3.4.24.82 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16303287&form=6&db=m Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.82 Epilepsy, Rolandic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718938&form=6&db=m Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. unassigned - 3.4.24.82 Facial Hemiatrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29878995&form=6&db=m Changes in Cutaneous Gene Expression after Microvascular Free Tissue Transfer in Parry-Romberg Syndrome. unassigned - 3.4.24.82 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29355494&form=6&db=m ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.82 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34169995&form=6&db=m Role of Adamts-1 in Pleomorphic Xanthoastrocytoma Tumor Cells Progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.82 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651776&form=6&db=m Expression of ADAMTS-1 mRNA in myocardium of viral heart disease mice and its clinical significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.82 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12386284&form=6&db=m A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.82 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18616564&form=6&db=m GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. therapeutic application,unassigned 2,0 3.4.24.82 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19167466&form=6&db=m Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.82 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15629898&form=6&db=m Leptin induces ovulation in GnRH-deficient mice. causal interaction,unassigned 2,0 3.4.24.82 Hyperparathyroidism, Primary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27844209&form=6&db=m The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.82 Hyperparathyroidism, Primary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28937860&form=6&db=m Association of ADAMTS4 and ADAMTS9 levels with cardiovascular risk in patients with primary hyperparathyroidism. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.82 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25716558&form=6&db=m Effects of baicalin on collagen ? and collagen ??? expression in pulmonary arteries of rats with hypoxic pulmonary hypertension. ongoing research,unassigned 4,0 3.4.24.82 Hypogonadism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30187439&form=6&db=m The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.82 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786374&form=6&db=m [EXPERIMENTAL STUDY ON LENTIVIRUS-MEDIATED MULTI-GENES CO-TRANSFECTION IN BONE MARROW MESENCHYMAL STEM CELLS FOR TREATMENT OF KNEE OSTEOARTHRITIS IN CYNOMOLGUS MONKEY]. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.82 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33116313&form=6&db=m Exuberant fibroblast activity compromises lung function via ADAMTS4. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 3.4.24.82 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33116313&form=6&db=m Exuberant fibroblast activity compromises lung function via ADAMTS4. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23602832&form=6&db=m Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-?B. unassigned - 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26495885&form=6&db=m Association between ADAMTS-4 gene polymorphism and lumbar disc degeneration in Chinese Han population. ongoing research,unassigned 1,0 3.4.24.82 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28512264&form=6&db=m Gallic acid inhibits the release of ADAMTS4 in nucleus pulposus cells by inhibiting p65 phosphorylation and acetylation of the NF-?B signaling pathway. unassigned - 3.4.24.82 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20857147&form=6&db=m Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with lumbar disc herniation. diagnostic usage,unassigned 4,0 3.4.24.82 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26663063&form=6&db=m [Association of ADAMTS-1 gene polymorphisms with ischemic stroke caused by large artery atherosclerosis]. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.82 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301579&form=6&db=m Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.82 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084617&form=6&db=m ADAMTS-4 in central nervous system pathologies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.82 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11254106&form=6&db=m Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.82 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23406982&form=6&db=m MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. unassigned - 3.4.24.82 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26003949&form=6&db=m ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. diagnostic usage,unassigned 2,0 3.4.24.82 Joint Instability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15334469&form=6&db=m Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.82 Kashin-Beck Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734379&form=6&db=m ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.82 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28323982&form=6&db=m Versican Proteolysis by ADAMTS Proteases and its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma. diagnostic usage,unassigned 2,0 3.4.24.82 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806998&form=6&db=m High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. ongoing research,unassigned 3,0 3.4.24.82 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319426&form=6&db=m ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.82 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319426&form=6&db=m ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.82 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900752&form=6&db=m Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.82 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194513&form=6&db=m The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.82 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314835&form=6&db=m Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.82 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878109&form=6&db=m Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10376599&form=6&db=m Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans. causal interaction,unassigned 3,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12527424&form=6&db=m Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880812&form=6&db=m ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. ongoing research,unassigned 4,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314835&form=6&db=m Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806998&form=6&db=m High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. ongoing research,unassigned 3,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17968946&form=6&db=m Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: Sustained release of a local antiinflammatory therapeutic. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19217322&form=6&db=m Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. therapeutic application,unassigned 1,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19449050&form=6&db=m Modification of palm oil for anti-inflammatory nutraceutical properties. unassigned - 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319426&form=6&db=m ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24732836&form=6&db=m Upregulation of tumor necrosis factor ? and ADAMTS-5, but not ADAMTS-4, in human intervertebral cartilage endplate with modic changes. unassigned - 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25707877&form=6&db=m Semaphorin 4D contributes to rheumatoid arthritis by inducing inflammatory cytokine production: Pathogenic and therapeutic implications. causal interaction,unassigned 2,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26217013&form=6&db=m C/EBP? and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling. ongoing research,unassigned 1,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29926003&form=6&db=m Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30730845&form=6&db=m Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies. unassigned - 3.4.24.82 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33757298&form=6&db=m Anti-Inflammatory Effects of Conditioned Medium of Periodontal Ligament-Derived Stem Cells on Chondrocytes, Synoviocytes, and Meniscus Cells. unassigned - 3.4.24.82 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661359&form=6&db=m Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease. causal interaction,unassigned 3,0 3.4.24.82 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301579&form=6&db=m Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.82 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28084617&form=6&db=m ADAMTS-4 in central nervous system pathologies. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.82 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17011710&form=6&db=m Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 3.4.24.82 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25045124&form=6&db=m Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-?B signaling pathways in human chondrocytes. causal interaction,unassigned 4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11325536&form=6&db=m Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis. unassigned - 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12202483&form=6&db=m Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161923&form=6&db=m ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. unassigned - 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16207326&form=6&db=m The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16549371&form=6&db=m Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments. diagnostic usage,unassigned 3,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17470431&form=6&db=m TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4. therapeutic application,unassigned 1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18328163&form=6&db=m The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941754&form=6&db=m Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation. therapeutic application,unassigned 1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19101611&form=6&db=m Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5. diagnostic usage,therapeutic application,unassigned 2,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21417219&form=6&db=m Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors. causal interaction,unassigned 1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21539915&form=6&db=m Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state. unassigned - 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21815191&form=6&db=m ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis. therapeutic application,unassigned 1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23406982&form=6&db=m MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. unassigned - 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126638&form=6&db=m Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25415648&form=6&db=m Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis. therapeutic application,unassigned 4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26380073&form=6&db=m Advances in understanding cartilage remodeling. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27401455&form=6&db=m Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29102725&form=6&db=m Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29236314&form=6&db=m IL-1?-induced miR-34a up-regulation inhibits Cyr61 to modulate osteoarthritis chondrocyte proliferation through ADAMTS-4. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29241192&form=6&db=m MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1?-Induced Catabolism in Human Articular Chondrocytes. unassigned - 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29806389&form=6&db=m [Effect of chondrogenesis related miR-4287 on expression of aggrecanase-1 in human chondrocytes]. diagnostic usage,unassigned 3,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30700002&form=6&db=m Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs. unassigned - 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31148341&form=6&db=m Cirsium japonicum var. maackii and apigenin block Hif-2?-induced osteoarthritic cartilage destruction. ongoing research,unassigned 2,0 3.4.24.82 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33350314&form=6&db=m Interrelationship of Osteopontin, MMP-9 and ADAMTS4 in Patients With Osteoarthritis Undergoing Total Joint Arthroplasty. ongoing research,unassigned 1,0 3.4.24.82 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26136925&form=6&db=m Effect of osteopontin on the mRNA expression of ADAMTS4 and ADAMTS5 in chondrocytes from patients with knee osteoarthritis. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.82 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32490633&form=6&db=m The utility of synovial fluid levels of ADAMTS9 and ADAMTS4 in predicting treatment responses to intraarticular steroid injections in patients with knee osteoarthritis therapeutic application,unassigned 1,0 3.4.24.82 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11108265&form=6&db=m ADAMTS-1: A cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone. therapeutic application,unassigned 1,0 3.4.24.82 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560840&form=6&db=m ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing. ongoing research,unassigned 4,0 3.4.24.82 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32568133&form=6&db=m The role of significantly deregulated MicroRNAs in osteosarcoma based on bioinformatic analysis. therapeutic application,unassigned 1,0 3.4.24.82 Periapical Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33676487&form=6&db=m Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.82 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31020669&form=6&db=m A disintegrin-like And metalloproteinase with thrombospondin-1 (ADAMTS-1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor-A, hypoxia-inducible factor-1?, and clinical parameters in patients with advanced periodontitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.82 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31020669&form=6&db=m A disintegrin-like And metalloproteinase with thrombospondin-1 (ADAMTS-1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor-A, hypoxia-inducible factor-1?, and clinical parameters in patients with advanced periodontitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.82 Pick Disease of the Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661359&form=6&db=m Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease. causal interaction,unassigned 3,0 3.4.24.82 Polymicrogyria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18718938&form=6&db=m Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. unassigned - 3.4.24.82 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31114288&form=6&db=m Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.82 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16192589&form=6&db=m Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.82 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30730845&form=6&db=m Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies. unassigned - 3.4.24.82 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15599946&form=6&db=m The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. causal interaction,unassigned 2,0 3.4.24.82 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590445&form=6&db=m Androgen regulates ADAMTS15 gene expression in prostate cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.82 Radicular Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33676487&form=6&db=m Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst. diagnostic usage,ongoing research,unassigned 3,1,0 3.4.24.82 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20598569&form=6&db=m Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.82 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26809777&form=6&db=m ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. ongoing research,unassigned 4,0 3.4.24.82 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31264504&form=6&db=m Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury. unassigned - 3.4.24.82 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16630594&form=6&db=m ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.24.82 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28425031&form=6&db=m The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.82 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29460983&form=6&db=m Transcriptional Profiling of Synovium in a Porcine Model of Early Post-traumatic Osteoarthritis. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.82 Tendinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18387286&form=6&db=m The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells. diagnostic usage,ongoing research,unassigned 2,2,0 3.4.24.82 Tendinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888475&form=6&db=m Promoter methylation status of the TIMP2 and ADAMTS4 genes and patellar tendinopathy. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0 3.4.24.82 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30989556&form=6&db=m Pro-atherogenic proteoglycanase ADAMTS-1 is down-regulated by lauric acid through PI3K and JNK signaling pathways in THP-1 derived macrophages. therapeutic application,unassigned 1,0 3.4.24.82 Tuberculosis, Spinal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28829887&form=6&db=m Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis. ongoing research,therapeutic application,unassigned 3,3,0 3.4.24.82 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17583485&form=6&db=m Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction. ongoing research,unassigned 4,0