3.4.24.80 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360607&form=6&db=m Looking at the proteases from a simple perspective. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9654189&form=6&db=m Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383907&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10914717&form=6&db=m Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11221894&form=6&db=m Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.80 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006939&form=6&db=m Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16930329&form=6&db=m Small adenocarcinoma of the lung: prognostic significance of central fibrosis chiefly because of its association with angiogenesis and lymphangiogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.4.24.80 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33282565&form=6&db=m Identifying MMP14 and COL12A1 as a potential combination of prognostic biomarkers in pancreatic ductal adenocarcinoma using integrated bioinformatics analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,1,1 3.4.24.80 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33683827&form=6&db=m LncRNA TP73-AS1 enhances the malignant properties of pancreatic ductal adenocarcinoma by increasing MMP14 expression through miRNA -200a sponging. unassigned - 3.4.24.80 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34517516&form=6&db=m Bioinformatics analysis identified MMP14 and COL12A1 as immune-related biomarkers associated with pancreatic adenocarcinoma prognosis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31522616&form=6&db=m FAM83A-AS1 promotes lung adenocarcinoma cell migration and invasion by targeting miR-150-5p and modifying MMP14. unassigned - 3.4.24.80 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9933692&form=6&db=m Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 3.4.24.80 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006939&form=6&db=m Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24877024&form=6&db=m Intravital imaging of mouse colonic adenoma using MMP-based molecular probes with multi-channel fluorescence endoscopy. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.80 Adrenal Cortex Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9933692&form=6&db=m Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 3.4.24.80 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29103177&form=6&db=m Matrix metalloproteinase 14 modulates diabetes and Alzheimer's disease cross-talk: a meta-analysis. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.80 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010778&form=6&db=m Membrane-type 1 matrix metalloproteinase regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.80 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21955474&form=6&db=m Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.80 Aneurysm, Dissecting http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16609908&form=6&db=m Up-regulation of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase were coupled with that of type I procollagen in granulation tissue response after the onset of aortic dissection. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.80 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381157&form=6&db=m Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 3.4.24.80 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11496285&form=6&db=m The expression and localization of membrane type-1 matrix metalloproteinase in human abdominal aortic aneurysms. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15300177&form=6&db=m Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20418476&form=6&db=m Alterations in membrane type-1 matrix metalloproteinase abundance following induction of thoracic aortic aneurysm in a murine model. unassigned - 3.4.24.80 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21955474&form=6&db=m Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.80 Aortic Aneurysm, Thoracic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27923483&form=6&db=m Regulation of membrane type-1 matrix metalloproteinase activity and intracellular localization in clinical thoracic aortic aneurysms. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.80 Aortic Valve Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21146836&form=6&db=m Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model. ongoing research,unassigned 3,0 3.4.24.80 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9639575&form=6&db=m Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan. unassigned - 3.4.24.80 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26315469&form=6&db=m Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 3.4.24.80 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26315469&form=6&db=m Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 3.4.24.80 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9923652&form=6&db=m New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from above. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.80 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959761&form=6&db=m Characterisation of the cell type-specificity of collagenase 3 mRNA expression in comparison with membrane type 1 matrix metalloproteinase and gelatinase A in the synovial membrane in rheumatoid arthritis. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.24.80 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15485996&form=6&db=m Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.24.80 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15986375&form=6&db=m Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts. ongoing research,therapeutic application,unassigned 3,3,0 3.4.24.80 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19248098&form=6&db=m Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30224512&form=6&db=m Therapeutic Potential of Mesenchymal Cell-Derived miRNA-150-5p-Expressing Exosomes in Rheumatoid Arthritis Mediated by the Modulation of MMP14 and VEGF. causal interaction,therapeutic application,unassigned 2,2,0 3.4.24.80 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12588417&form=6&db=m Soluble membrane-type 1 matrix metalloproteinase (MT1-MMP) and gelatinase A (MMP-2) in induced sputum and bronchoalveolar lavage fluid of human bronchial asthma and bronchiectasis. ongoing research,unassigned 2,0 3.4.24.80 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34414666&form=6&db=m Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.80 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10731924&form=6&db=m Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions. diagnostic usage,ongoing research,unassigned 4,4,0 3.4.24.80 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17827712&form=6&db=m Distribution profiles of membrane Type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) in rabbit atherosclerosis: comparison with plaque instability analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4 3.4.24.80 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19487339&form=6&db=m LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. causal interaction,unassigned 3,0 3.4.24.80 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33767172&form=6&db=m Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis. causal interaction,therapeutic application,unassigned 2,1,0 3.4.24.80 Bicuspid Aortic Valve Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17382648&form=6&db=m Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3 3.4.24.80 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19567368&form=6&db=m Proteomics characterization of cell membrane blebs in human retinal pigment epithelium cells. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 3.4.24.80 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23499464&form=6&db=m Novel Proteolytic Microvesicles Released from Human Macrophages after Exposure to Tobacco Smoke. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.80 Bone Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28914985&form=6&db=m Cherubism mice also deficient in c-Fos exhibit inflammatory bone destruction executed by macrophages that express MMP14 despite the absence of TRAP+ osteoclasts. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 3.4.24.80 Bone Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20714408&form=6&db=m MT1-MMP: A novel component of the macrophage cell fusion machinery. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11817712&form=6&db=m Effects of 17beta-estradiol on the expression of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in human osteoblastic MG-63 cell cultures. causal interaction,unassigned 3,0 3.4.24.80 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14535636&form=6&db=m 1alpha,25-dihydroxyvitamin D3 regulates the expression of membrane-type matrix metalloproteinase-1 in normal human osteoblast-like cells. unassigned - 3.4.24.80 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691682&form=6&db=m Parathyroid hormone inhibits the expression of membrane-type matrix metalloproteinase-1 (MT1-MMP) in osteoblast-like MG-63 cells. causal interaction,unassigned 4,0 3.4.24.80 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18301992&form=6&db=m Human breast adenocarcinoma (MDA-231) and human lung squamous cell carcinoma (Hara) do not have the ability to cause bone resorption by themselves during the establishment of bone metastasis. ongoing research,unassigned 2,0 3.4.24.80 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18812854&form=6&db=m Global age-dependent differences in gene expression in response to calvarial injury. unassigned - 3.4.24.80 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32024800&form=6&db=m Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases. ongoing research,unassigned 2,0 3.4.24.80 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963646&form=6&db=m Angiotensin type 1 receptor blockage improves ischemic injury following transient focal cerebral ischemia. causal interaction,therapeutic application,unassigned 2,4,0 3.4.24.80 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18567795&form=6&db=m Tumor environment dictates medulloblastoma cancer stem cell expression and invasive phenotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.4.24.80 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20195390&form=6&db=m The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 3.4.24.80 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21088866&form=6&db=m A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.24.80 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22692046&form=6&db=m Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 3.4.24.80 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26052095&form=6&db=m MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.80 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464124&form=6&db=m Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.80 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33707311&form=6&db=m Hematopoietic stem cell gene therapy targeting TGF? enhances the efficacy of irradiation therapy in a preclinical glioblastoma model. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8665498&form=6&db=m Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2. ongoing research,unassigned 4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9166284&form=6&db=m Implication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9371497&form=6&db=m Tyrosine phosphorylation mediates ConA-induced membrane type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in MDA-MB-231 human breast carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9413149&form=6&db=m Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9655252&form=6&db=m Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10391091&form=6&db=m Significance of membrane type 1 matrix metalloproteinase expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10551322&form=6&db=m Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10658069&form=6&db=m Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728589&form=6&db=m Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11335709&form=6&db=m Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11688960&form=6&db=m MMP-9 secretion and MMP-2 activation distinguish invasive and metastatic sublines of a mouse mammary carcinoma system showing epithelial-mesenchymal transition traits. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11724803&form=6&db=m Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429818&form=6&db=m Gelatin zymography and substrate cleavage assays of matrix metalloproteinase-2 in breast carcinoma cells overexpressing membrane type-1 matrix metalloproteinase. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12672023&form=6&db=m Restricted expression of membrane type 1-matrix metalloproteinase by myofibroblasts adjacent to human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597417&form=6&db=m Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744781&form=6&db=m Pro-matrix metalloproteinase-2 transfection increases orthotopic primary growth and experimental metastasis of MDA-MB-231 human breast cancer cells in nude mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15118097&form=6&db=m Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. ongoing research,unassigned 4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15255181&form=6&db=m Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15566663&form=6&db=m [Significance of membrane type-1 matrix metalloproteinase expression in breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140936&form=6&db=m Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525713&form=6&db=m Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16540652&form=6&db=m Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17257129&form=6&db=m The clinicopathological and prognostic significance of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-9 according to their localization in invasive breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17274367&form=6&db=m [Effects of MT1-MMP on the in vitro invasiveness of breast cancer cells] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071307&form=6&db=m MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18505826&form=6&db=m Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010933&form=6&db=m Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20432456&form=6&db=m Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20529824&form=6&db=m Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20650008&form=6&db=m Degradation of HER2/neu by ANT2 shRNA suppresses migration and invasiveness of breast cancer cells. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21344390&form=6&db=m New signaling pathways from cancer progression modulators to mRNA expression of matrix metalloproteinases in breast cancer cells. causal interaction,unassigned 1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21706048&form=6&db=m MT1-MMP protects breast carcinoma cells against type I collagen-induced apoptosis. ongoing research,therapeutic application,unassigned 3,2,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22842186&form=6&db=m In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines. causal interaction,unassigned 3,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22922740&form=6&db=m Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22995648&form=6&db=m Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23629968&form=6&db=m EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23812425&form=6&db=m KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24202705&form=6&db=m NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24657728&form=6&db=m The emerging role of MMP14 in brain tumorigenesis and future therapeutics. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25015290&form=6&db=m CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25241893&form=6&db=m NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. causal interaction,unassigned 1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25710962&form=6&db=m Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25755834&form=6&db=m The overexpression membrane type 1 matrix metalloproteinase is associated with the progression and prognosis in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637400&form=6&db=m ELK3 Expression Correlates With Cell Migration, Invasion, and Membrane Type 1-Matrix Metalloproteinase Expression in MDA-MB-231 Breast Cancer Cells. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26663028&form=6&db=m Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26806746&form=6&db=m [Expression pattern of membrane type-1 matrix metalloproteinase in primary breast carcinomas]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893363&form=6&db=m mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27116935&form=6&db=m LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP. causal interaction,unassigned 4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27916539&form=6&db=m Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28393207&form=6&db=m RNA interference-mediated silencing of ppGalNAc-T1 and ppGalNAc-T2 inhibits invasion and increases chemosensitivity potentially by reducing terminal ?2,3 sialylation and MMP14 expression in triple?negative breast cancer cells. unassigned - 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28713815&form=6&db=m Bioinformatic Prediction of Possible Targets and Mechanisms of Action of the Green Tea Compound Epigallocatechin-3-Gallate Against Breast Cancer. causal interaction,unassigned 4,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28954862&form=6&db=m Nck deficiency is associated with delayed breast carcinoma progression and reduced metastasis. ongoing research,unassigned 3,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29934628&form=6&db=m PROX1 is a transcriptional regulator of MMP14. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502358&form=6&db=m The membrane tethered matrix metalloproteinase MT1-MMP triggers an outside-in DNA damage response that impacts chemo- and radiotherapy responses of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30521382&form=6&db=m MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34237080&form=6&db=m MT1-MMP-dependent ECM processing regulates laminB1 stability and mediates replication fork restart. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367983&form=6&db=m Protein Tyrosine Kinase 7 Regulates EGFR/Akt Signaling Pathway and Correlates With Malignant Progression in Triple-Negative Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.80 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531530&form=6&db=m TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia. unassigned - 3.4.24.80 Bronchiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12588417&form=6&db=m Soluble membrane-type 1 matrix metalloproteinase (MT1-MMP) and gelatinase A (MMP-2) in induced sputum and bronchoalveolar lavage fluid of human bronchial asthma and bronchiectasis. ongoing research,unassigned 2,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383907&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11221894&form=6&db=m Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16251193&form=6&db=m Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391876&form=6&db=m Down-regulation of MT1-MMP expression suppresses tumor cell invasion in metastatic human SW626 ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536854&form=6&db=m Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24657728&form=6&db=m The emerging role of MMP14 in brain tumorigenesis and future therapeutics. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25592038&form=6&db=m Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040767&form=6&db=m A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26047679&form=6&db=m miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26084291&form=6&db=m miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26175856&form=6&db=m MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259238&form=6&db=m miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30291676&form=6&db=m Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase: Impact on U87 glioblastoma cell invasion and autophagy signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30874539&form=6&db=m AID modulates carcinogenesis network via DNA demethylation in bladder urothelial cell carcinoma. unassigned - 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848463&form=6&db=m microRNA-26a Directly Targeting MMP14 and MMP16 Inhibits the Cancer Cell Proliferation, Migration and Invasion in Cutaneous Squamous Cell Carcinoma. unassigned - 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32930509&form=6&db=m Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727629&form=6&db=m Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8882706&form=6&db=m Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8938135&form=6&db=m Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8988738&form=6&db=m Increased expression of membrane type 1-matrix metalloproteinase in head and neck carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9605772&form=6&db=m Transformation of epithelial Madin-Darby canine kidney cells with p60(v-src) induces expression of membrane-type 1 matrix metalloproteinase and invasiveness. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9748137&form=6&db=m Augmented membrane type 1 matrix metalloproteinase (MT1-MMP):MMP-2 messenger RNA ratio in gastric carcinomas with poor prognosis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027405&form=6&db=m Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10197640&form=6&db=m Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383907&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473866&form=6&db=m Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10491020&form=6&db=m Expression of membrane type 1-matrix metalloproteinase in laryngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10504584&form=6&db=m Role of membrane type 1-matrix metalloproteinase and gelatinase A in head and neck squamous cell carcinoma invasion in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10551322&form=6&db=m Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10820340&form=6&db=m Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840163&form=6&db=m Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10910039&form=6&db=m Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987249&form=6&db=m Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235994&form=6&db=m Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297247&form=6&db=m Ets-1 messenger RNA expression is a novel marker of poor survival in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11335709&form=6&db=m Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11355270&form=6&db=m MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11925127&form=6&db=m Anti-invasive effect of MMI-166, a new selective matrix metalloproteinase inhibitor, in cervical carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006939&form=6&db=m Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12056775&form=6&db=m Expression of matrix metalloprotease-2 (MMP-2) and the activator membrane type 1 (MT1-MMP) in canine mammary carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14673954&form=6&db=m Fibroblast growth factor-1 transcriptionally induces membrane type-1 matrix metalloproteinase expression in prostate carcinoma cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044508&form=6&db=m Activation of WNT family expression and signaling in squamous cell carcinomas of the oral cavity. causal interaction,unassigned 4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381157&form=6&db=m Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15563089&form=6&db=m [Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592504&form=6&db=m Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16061633&form=6&db=m Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619276&form=6&db=m Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979746&form=6&db=m Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17140440&form=6&db=m Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17158885&form=6&db=m Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18642282&form=6&db=m MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18667779&form=6&db=m [Effect of bone morphogenetic protein-2 on the expression of membrane Type 1-matrix metalloproteinase in human A549 lung carcinoma cells] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18976802&form=6&db=m Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: high level expression in clear cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509114&form=6&db=m Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19706774&form=6&db=m Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20605790&form=6&db=m Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes. unassigned - 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20946474&form=6&db=m Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21965271&form=6&db=m Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23804419&form=6&db=m Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time. ongoing research,unassigned 4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24603589&form=6&db=m Visual and automated assessment of matrix metalloproteinase-14 tissue expression for the evaluation of ovarian cancer prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24753582&form=6&db=m Control of MT1-MMP transport by atypical PKC during breast-cancer progression. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24789545&form=6&db=m Matrix metalloproteinase-14 expression and its prognostic value in cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25268950&form=6&db=m miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25552509&form=6&db=m [Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26106602&form=6&db=m Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26916665&form=6&db=m Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29265076&form=6&db=m [Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29286099&form=6&db=m Downregulation of matrix metalloproteinase 14 by the antitumor miRNA, miR-150-5p, inhibits the aggressiveness of lung squamous cell carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31011632&form=6&db=m Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949690&form=6&db=m Clinical significance of AJUBA, YAP1, and MMP14 expression in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848463&form=6&db=m microRNA-26a Directly Targeting MMP14 and MMP16 Inhibits the Cancer Cell Proliferation, Migration and Invasion in Cutaneous Squamous Cell Carcinoma. unassigned - 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32930509&form=6&db=m Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33552276&form=6&db=m Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2? in osteosarcoma and prostate carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006939&form=6&db=m Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9098015&form=6&db=m Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9514536&form=6&db=m Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10208467&form=6&db=m Increased expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 with tumor dedifferentiation in hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10914717&form=6&db=m Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10933057&form=6&db=m Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10951628&form=6&db=m [The role of membrane-type 1 matrix metalloproteinase in the invasion and metastasis of hepatocellular carcinoma] causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788895&form=6&db=m A new pseudo-peptide of Arg-Gly-Asp (RGD) inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma. causal interaction,unassigned 4,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16419154&form=6&db=m Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17219425&form=6&db=m Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18025272&form=6&db=m Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21298348&form=6&db=m Role of MMP14 Gene Polymorphisms in Susceptibility and Pathological Development to Hepatocellular Carcinoma. ongoing research,unassigned 2,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24634581&form=6&db=m Tetracycline derivative minocycline inhibits autophagy and inflammation in concanavalin-a-activated human hepatoma cells. ongoing research,unassigned 3,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25549355&form=6&db=m miR-150-5p inhibits hepatoma cell migration and invasion by targeting MMP14. causal interaction,ongoing research,unassigned 1,1,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29934628&form=6&db=m PROX1 is a transcriptional regulator of MMP14. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32122646&form=6&db=m High MMP14 expression is predictive of poor prognosis in resectable hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.80 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34007838&form=6&db=m Gene Polymorphism of MUC15, MMP14, BRAF, and COL1A1 Is Associated with Capsule Formation in Hepatocellular Carcinoma. causal interaction,unassigned 1,0 3.4.24.80 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218449&form=6&db=m Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.80 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20127359&form=6&db=m Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events. causal interaction,unassigned 4,0 3.4.24.80 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22086850&form=6&db=m Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. therapeutic application,unassigned 1,0 3.4.24.80 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15118611&form=6&db=m Functional role of matrix metalloproteinases in ovarian tumor cell plasticity. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18976802&form=6&db=m Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: high level expression in clear cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152495&form=6&db=m Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein. ongoing research,unassigned 2,0 3.4.24.80 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23670532&form=6&db=m Loss of HOXD10 expression induced by upregulation of miR-10b accelerates the migration and invasion activities of ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592504&form=6&db=m Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 3.4.24.80 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979746&form=6&db=m Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 3.4.24.80 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17140440&form=6&db=m Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.80 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21965271&form=6&db=m Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2 3.4.24.80 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116394&form=6&db=m Effects of CoCl2-simulated hypoxia on the expression levels of matrix metalloproteinases in renal adenocarcinoma cells and renal tubular epithelial cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.80 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641935&form=6&db=m Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10376963&form=6&db=m Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10504584&form=6&db=m Role of membrane type 1-matrix metalloproteinase and gelatinase A in head and neck squamous cell carcinoma invasion in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10820340&form=6&db=m Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840163&form=6&db=m Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987249&form=6&db=m Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235988&form=6&db=m Heat shock-mediated transient increase in intracellular 3',5'-cyclic AMP results in tumor specific suppression of membrane type 1-matrix metalloproteinase production and progelatinase A activation. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11355270&form=6&db=m MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619276&form=6&db=m Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20605790&form=6&db=m Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes. unassigned - 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23804419&form=6&db=m Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time. ongoing research,unassigned 4,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25268950&form=6&db=m miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29265076&form=6&db=m [Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29286099&form=6&db=m Downregulation of matrix metalloproteinase 14 by the antitumor miRNA, miR-150-5p, inhibits the aggressiveness of lung squamous cell carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31011632&form=6&db=m Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848463&form=6&db=m microRNA-26a Directly Targeting MMP14 and MMP16 Inhibits the Cancer Cell Proliferation, Migration and Invasion in Cutaneous Squamous Cell Carcinoma. unassigned - 3.4.24.80 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21146836&form=6&db=m Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model. ongoing research,unassigned 3,0 3.4.24.80 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178334&form=6&db=m A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.4.24.80 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25263346&form=6&db=m PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts. causal interaction,unassigned 4,0 3.4.24.80 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31278967&form=6&db=m MMP-14 degrades tropoelastin and elastin. unassigned - 3.4.24.80 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25119918&form=6&db=m [Association of MMP-14 gene polymorphism with cerebral infarction - a case-control study]. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0 3.4.24.80 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360607&form=6&db=m Looking at the proteases from a simple perspective. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Cherubism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28914985&form=6&db=m Cherubism mice also deficient in c-Fos exhibit inflammatory bone destruction executed by macrophages that express MMP14 despite the absence of TRAP+ osteoclasts. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0 3.4.24.80 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18329694&form=6&db=m Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.80 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473866&form=6&db=m Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.80 Choriocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24941254&form=6&db=m HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.80 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006939&form=6&db=m Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21634125&form=6&db=m [Identification of protein markers for serum diagnosis of cancer based on microRNA expression profiling]. diagnostic usage,unassigned 2,0 3.4.24.80 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10733122&form=6&db=m Membrane-type 1 matrix metalloproteinase mRNA expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12185585&form=6&db=m Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.80 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19020773&form=6&db=m Overexpression of MT1-MMP is insufficient to increase experimental liver metastasis of human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.80 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22296769&form=6&db=m MMP-14 Is Expressed in Preeclamptic Placentas and Mediates Release of Soluble Endoglin. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.80 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26106602&form=6&db=m Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30120968&form=6&db=m MMP14 predicts a poor prognosis in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.4.24.80 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32015228&form=6&db=m How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.80 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21518755&form=6&db=m Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.80 Corneal Dystrophies, Hereditary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30489629&form=6&db=m Downregulation of IL-7 and IL-7R Reduces Membrane-Type Matrix Metalloproteinase 14 in Granular Corneal Dystrophy Type 2 Keratocyte. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.80 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19264910&form=6&db=m Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.80 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22801544&form=6&db=m When MT1-MMP meets ADAMs. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.80 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25015352&form=6&db=m Evidence for the involvement of MMP14 in MMP2 processing and recruitment in exosomes of corneal fibroblasts. ongoing research,therapeutic application,unassigned 4,3,0 3.4.24.80 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26284550&form=6&db=m MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect. unassigned - 3.4.24.80 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27327585&form=6&db=m Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.80 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32268857&form=6&db=m Proteomics-based Characterization of the Effects of MMP14 on the Protein Content of Exosomes from Corneal Fibroblasts. causal interaction,unassigned 3,0 3.4.24.80 Corneal Opacity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21160532&form=6&db=m Matrix metalloproteinase 14 overexpression reduces corneal scarring. causal interaction,unassigned 1,0 3.4.24.80 Cystadenocarcinoma, Mucinous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9654189&form=6&db=m Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Dental Caries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28348596&form=6&db=m Genetic Association of MMP10, MMP14, and MMP16 with Dental Caries. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 3.4.24.80 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944163&form=6&db=m Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.80 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21826658&form=6&db=m Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes. ongoing research,unassigned 1,0 3.4.24.80 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24243641&form=6&db=m A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome. causal interaction,unassigned 3,0 3.4.24.80 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186369&form=6&db=m Hypoxia induces the expression of membrane-type 1 matrix metalloproteinase in retinal glial cells. causal interaction,unassigned 1,0 3.4.24.80 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29853773&form=6&db=m Matrix metalloproteinase-14 is a biomarker of angiogenic activity in proliferative diabetic retinopathy. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.4.24.80 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16109597&form=6&db=m Matrix metalloproteinase-13 and membrane type-1 matrix metalloproteinase in peritoneal fluid of women with endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28120021&form=6&db=m Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.24.80 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18716553&form=6&db=m Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.24.80 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24196787&form=6&db=m MicroRNA-133a regulates the mRNAs of two invadopodia-related proteins, FSCN1 and MMP14, in esophageal cancer. therapeutic application,unassigned 1,0 3.4.24.80 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26916665&form=6&db=m Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.4.24.80 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949690&form=6&db=m Clinical significance of AJUBA, YAP1, and MMP14 expression in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.4.24.80 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32930509&form=6&db=m Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18521441&form=6&db=m Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8706726&form=6&db=m Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9413149&form=6&db=m Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872597&form=6&db=m Regulation of matrix metalloproteinase-2 (gelatinase A, MMP-2), membrane-type matrix metalloproteinase-1 (MT1-MMP) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression by elastin-derived peptides in human HT-1080 fibrosarcoma cell line. ongoing research,unassigned 3,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10548512&form=6&db=m Heat shock suppresses membrane type 1-matrix metalloproteinase production and progelatinase A activation in human fibrosarcoma HT-1080 cells and thereby inhibits cellular invasion. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235988&form=6&db=m Heat shock-mediated transient increase in intracellular 3',5'-cyclic AMP results in tumor specific suppression of membrane type 1-matrix metalloproteinase production and progelatinase A activation. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15147870&form=6&db=m Cellular cholesterol regulates MT1 MMP dependent activation of MMP 2 via MEK-1 in HT1080 fibrosarcoma cells. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381157&form=6&db=m Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309669&form=6&db=m Inhibitory effects of a benz[f]indole-4,9-dione analog on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells. ongoing research,unassigned 4,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18495463&form=6&db=m Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. ongoing research,unassigned 4,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21937212&form=6&db=m Antimetastatic activity of pinosylvin, a natural stilbenoid, is associated with the suppression of matrix metalloproteinases. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25174588&form=6&db=m CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity--role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28675805&form=6&db=m Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727629&form=6&db=m Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.80 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8938135&form=6&db=m Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.80 Giant Cell Tumor of Bone http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26078788&form=6&db=m Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone. unassigned - 3.4.24.80 Giant Cell Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26078788&form=6&db=m Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone. unassigned - 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10389763&form=6&db=m Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10963898&form=6&db=m Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells. ongoing research,unassigned 4,0 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11583578&form=6&db=m Calmodulin inhibitors trigger the proteolytic processing of membrane type-1 matrix metalloproteinase, but not its shedding in glioblastoma cells. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18267120&form=6&db=m Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,2 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22692046&form=6&db=m Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23582684&form=6&db=m The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells. ongoing research,unassigned 1,0 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24462646&form=6&db=m Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722242&form=6&db=m MicroRNA-133b inhibits cell migration and invasion by targeting matrix metalloproteinase 14 in glioblastoma. unassigned - 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30291676&form=6&db=m Dual functions of ARP101 in targeting membrane type-1 matrix metalloproteinase: Impact on U87 glioblastoma cell invasion and autophagy signaling. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.80 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677819&form=6&db=m CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9410885&form=6&db=m Matrix metalloproteinase-2 activation modulates glioma cell migration. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9413149&form=6&db=m Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10389763&form=6&db=m Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235952&form=6&db=m Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11716070&form=6&db=m Membrane-type matrix metalloproteinases (MT-MMPs): expression and function during glioma invasion. causal interaction,unassigned 3,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809713&form=6&db=m Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12134900&form=6&db=m Modulation of phorbol ester-induced regulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases by SB203580, a specific inhibitor of p38 mitogen-activated protein kinase. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381157&form=6&db=m Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701277&form=6&db=m Mechanisms of action of rapamycin in gliomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743799&form=6&db=m Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15992376&form=6&db=m Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg. ongoing research,unassigned 3,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19272160&form=6&db=m A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20809186&form=6&db=m Expressions of matrix metalloproteinase-7 and matrix metalloproteinase-14 associated with the activation of extracellular signal-regulated kinase1/2 in human brain gliomas of different pathological grades. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21324352&form=6&db=m Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23166329&form=6&db=m Neurokinin-1 receptor directly mediates glioma cell migration by up-regulation of matrix metalloproteinase-2 (MMP-2) and membrane type 1-matrix metalloproteinase (MT1-MMP). causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23582684&form=6&db=m The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells. ongoing research,unassigned 1,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24014382&form=6&db=m Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24156018&form=6&db=m Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24657728&form=6&db=m The emerging role of MMP14 in brain tumorigenesis and future therapeutics. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24752463&form=6&db=m Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline. causal interaction,unassigned 3,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26052095&form=6&db=m MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464124&form=6&db=m Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27613828&form=6&db=m Human astrocytes secrete IL-6 to promote glioma migration and invasion through upregulation of cytomembrane MMP14. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29885519&form=6&db=m Methylation-mediated miR-155-FAM133A axis contributes to the attenuated invasion and migration of IDH mutant gliomas. unassigned - 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31298339&form=6&db=m MFI2-AS1 regulates the aggressive phenotypes in glioma by modulating MMP14 via a positive feedback loop. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31443114&form=6&db=m TMZ regulates GBM stemness via MMP14-DLL4-Notch3 pathway. ongoing research,unassigned 4,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32872536&form=6&db=m Neoplastic Cells are the Major Source of MT-MMPs in IDH1-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration. causal interaction,unassigned 2,0 3.4.24.80 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34345216&form=6&db=m SUMOylation of IGF2BP2 promotes vasculogenic mimicry of glioma via regulating OIP5-AS1/miR-495-3p axis. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.80 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9848780&form=6&db=m Enhanced expression of membrane type-1 matrix metalloproteinase in mesangial proliferative glomerulonephritis. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Hajdu-Cheney Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28675805&form=6&db=m Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840163&form=6&db=m Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633349&form=6&db=m High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Hemangiosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19224446&form=6&db=m Activation of matrix metalloproteinase (MMP)-2 by membrane type 1-MMP and abnormal immunolocalization of the basement membrane components laminin and type IV collagen in canine spontaneous hemangiosarcomas. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.80 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488433&form=6&db=m The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. causal interaction,unassigned 4,0 3.4.24.80 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17187364&form=6&db=m The hepatitis B virus X protein promotes hepatocellular carcinoma metastasis by upregulation of matrix metalloproteinases. causal interaction,unassigned 4,0 3.4.24.80 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26537061&form=6&db=m Interaction between hepatic membrane type 1 matrix metalloproteinase and acireductone dioxygenase 1 regulates hepatitis C virus infection. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.4.24.80 Histiocytoma, Malignant Fibrous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18521441&form=6&db=m Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27833045&form=6&db=m Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.80 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18025411&form=6&db=m In vivo effects of insulin and free fatty acids on matrix metalloproteinases in rat aorta. unassigned - 3.4.24.80 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18625123&form=6&db=m Effects of insulin and free fatty acids on matrix metalloproteinases. unassigned - 3.4.24.80 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360607&form=6&db=m Looking at the proteases from a simple perspective. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21472010&form=6&db=m RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors. diagnostic usage,unassigned 4,0 3.4.24.80 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31470617&form=6&db=m Mayaro Virus Infects Human Chondrocytes and Induces the Expression of Arthritis-Related Genes Associated with Joint Degradation. causal interaction,unassigned 3,0 3.4.24.80 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33090092&form=6&db=m Matrix metalloproteinase-14 regulates collagen degradation and migration of mononuclear cells during infection with genotype VII Newcastle disease virus. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.80 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34107282&form=6&db=m Matrix metalloproteinase 14 regulates HSV-1 infection in neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 3.4.24.80 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22140598&form=6&db=m Membrane type-1 matrix metalloproteinase (MT1-MMP) correlates with the expression and activation of matrix metalloproteinase-2 (MMP-2) in inflammatory breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.80 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26322093&form=6&db=m The role of matrix metalloproteinase 14 polymorphisms in susceptibility to intervertebral disc degeneration in the Chinese Han population. unassigned - 3.4.24.80 Intervertebral Disc Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26620678&form=6&db=m Downregulation of microRNA-193a-3p is involved in invertebral disc degeneration by targeting MMP14. causal interaction,unassigned 2,0 3.4.24.80 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28675805&form=6&db=m Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19438747&form=6&db=m Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: implications for mechanisms of keloid progression. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Keratoconus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11148603&form=6&db=m Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in normal and keratoconus corneas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.80 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633349&form=6&db=m High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15563089&form=6&db=m [Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281245&form=6&db=m Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26138721&form=6&db=m Expression Levels of Myostatin and Matrix Metalloproteinase 14 mRNAs in Uterine Leiomyoma are Correlated With Dysmenorrhea. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34256950&form=6&db=m Extracellular matrix remodeling and inflammatory pathway in human endometrium: insights from uterine leiomyomas. causal interaction,unassigned 2,0 3.4.24.80 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20138666&form=6&db=m The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.80 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21223734&form=6&db=m [Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Leukemia, Monocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20138666&form=6&db=m The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.80 Leukemia, Monocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21223734&form=6&db=m [Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353746&form=6&db=m Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353746&form=6&db=m Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24213464&form=6&db=m Membrane Type-1 Matrix Metalloproteinase Expression in Acute Myeloid Leukemia and Its Upregulation by Tumor Necrosis Factor-?. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Lichen Planus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18642282&form=6&db=m MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 3.4.24.80 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18642282&form=6&db=m MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 3.4.24.80 Lipedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32792644&form=6&db=m The MMP14-caveolin axis and its potential relevance for lipoedema. causal interaction,unassigned 3,0 3.4.24.80 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11682030&form=6&db=m Dynamic change of cells expressing MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat. ongoing research,unassigned 4,0 3.4.24.80 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34504910&form=6&db=m Secreted matrix metalloproteinase-14 is a predictor for antifibrotic effect of IC-2-engineered mesenchymal stem cell sheets on liver fibrosis in mice. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 3.4.24.80 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14761770&form=6&db=m Increased matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase activity and expression in heterotopically transplanted murine tracheas. causal interaction,unassigned 4,0 3.4.24.80 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28120021&form=6&db=m Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.24.80 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32550243&form=6&db=m Prediction of repurposed drugs for treating lung injury in COVID-19. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32934806&form=6&db=m Prediction of repurposed drugs for treating lung injury in COVID-19. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.80 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499615&form=6&db=m Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. unassigned - 3.4.24.80 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22086850&form=6&db=m Regulation of matrix metalloproteinase genes by E2F transcription factors: Rb-Raf-1 interaction as a novel target for metastatic disease. therapeutic application,unassigned 1,0 3.4.24.80 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23409034&form=6&db=m Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.24.80 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23605953&form=6&db=m Regulation of membrane-type 1 matrix metalloproteinase expression by zonula occludens-2 in human lung cancer cells. ongoing research,unassigned 4,0 3.4.24.80 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24012124&form=6&db=m CK2 inhibitor CX4945 induces sequential inactivation of proteins in the signaling pathways related with cell migration and suppresses metastasis of A549 human lung cancer cells. ongoing research,unassigned 3,0 3.4.24.80 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28013056&form=6&db=m Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.24.80 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34114806&form=6&db=m Noninvasive Bioluminescence Imaging of Matrix Metalloproteinase-14 Activity in Lung Cancer Using a Membrane-Bound Biosensor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235994&form=6&db=m Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448063&form=6&db=m Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15563089&form=6&db=m [Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619276&form=6&db=m Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25268950&form=6&db=m miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748728&form=6&db=m Increased expression of MMP14 correlates with the poor prognosis of Chinese patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 3.4.24.80 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26175856&form=6&db=m MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27562173&form=6&db=m Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.80 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397871&form=6&db=m Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.80 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32974187&form=6&db=m Matrix Metallopeptidase 14: A Candidate Prognostic Biomarker for Diffuse Large B-Cell Lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 3.4.24.80 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32974187&form=6&db=m Matrix Metallopeptidase 14: A Candidate Prognostic Biomarker for Diffuse Large B-Cell Lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223295&form=6&db=m Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. ongoing research,unassigned 3,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10409657&form=6&db=m Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861447&form=6&db=m Expression of integrin alpha(v)beta(3) correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10878545&form=6&db=m Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11564733&form=6&db=m Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857380&form=6&db=m Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12473670&form=6&db=m Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. therapeutic application,unassigned 1,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941789&form=6&db=m Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14962105&form=6&db=m Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15059909&form=6&db=m Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15208686&form=6&db=m Functional role of MIA in melanocytes and early development of melanoma. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16829852&form=6&db=m Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308124&form=6&db=m mda-9/Syntenin regulates the metastatic phenotype in human melanoma cells by activating nuclear factor-kappaB. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17498549&form=6&db=m Elastin-elastases and inflamm-aging. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045645&form=6&db=m Expression and prognostic role of MMP2, MMP9, MMP13, and MMP14 matrix metalloproteinases in sinonasal and oral malignant melanomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18442402&form=6&db=m The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. therapeutic application,unassigned 1,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18971959&form=6&db=m ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19308689&form=6&db=m Emerging Roles of PAR-1 and PAFR in Melanoma Metastasis. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19434087&form=6&db=m Shedding light on proteolytic cleavage of CD44: the responsible sheddase and functional significance of shedding. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801067&form=6&db=m Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24335752&form=6&db=m Downregulation of reversion-inducing cysteine-rich protein with Kazal motifs in malignant melanoma: inverse correlation with membrane-type 1-matrix metalloproteinase and tissue inhibitor of metalloproteinase 2. causal interaction,diagnostic usage,unassigned 4,2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24492617&form=6&db=m Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24733393&form=6&db=m The tetraspanin CD81 protein increases melanoma cell motility by up-regulating metalloproteinase MT1-MMP expression through the pro-oncogenic Akt-dependent Sp1 activation signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25808867&form=6&db=m MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma. ongoing research,unassigned 2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26392417&form=6&db=m MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27096756&form=6&db=m Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27221755&form=6&db=m The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27564100&form=6&db=m Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29712618&form=6&db=m Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and ?1-integrin activation. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.80 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33924099&form=6&db=m Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.80 membrane-type matrix metalloproteinase-1 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33805743&form=6&db=m Loss of MT1-MMP in Alveolar Epithelial Cells Exacerbates Pulmonary Fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.80 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27779709&form=6&db=m Comparative gene expression profiling of ADAMs, MMPs, TIMPs, EMMPRIN, EGF-R and VEGFA in low grade meningioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.80 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19753302&form=6&db=m Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.80 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23626673&form=6&db=m Genetic variants associated with increased risk of malignant pleural mesothelioma: a genome-wide association study. unassigned - 3.4.24.80 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28918236&form=6&db=m Gene expression profiles of cell adhesion molecules, matrix metalloproteinases and their tissue inhibitors in canine oral tumors. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.80 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353746&form=6&db=m Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20643648&form=6&db=m Cardiac restricted overexpression of membrane type-1 matrix metalloproteinase causes adverse myocardial remodeling following myocardial infarction. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.80 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21666120&form=6&db=m Direct Regulation of Membrane Type-1 Matrix Metalloproteinase Following Myocardial Infarction Causes Changes in Survival, Cardiac Function and Remodeling. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,2 3.4.24.80 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18065523&form=6&db=m Interruption of endothelin signaling modifies membrane type 1 matrix metalloproteinase activity during ischemia and reperfusion. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.80 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25829357&form=6&db=m Matrix Metalloproteinase 14 Overexpression Is Correlated with the Progression and Poor Prognosis of Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.80 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040767&form=6&db=m A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.80 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26175856&form=6&db=m MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32595725&form=6&db=m Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology. therapeutic application,unassigned 1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8882706&form=6&db=m Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9548812&form=6&db=m Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. causal interaction,unassigned 4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9933692&form=6&db=m Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027405&form=6&db=m Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600499&form=6&db=m Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display library. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10658069&form=6&db=m Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840163&form=6&db=m Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10951628&form=6&db=m [The role of membrane-type 1 matrix metalloproteinase in the invasion and metastasis of hepatocellular carcinoma] causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10998420&form=6&db=m Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2. causal interaction,unassigned 4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235994&form=6&db=m Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448063&form=6&db=m Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788895&form=6&db=m A new pseudo-peptide of Arg-Gly-Asp (RGD) inhibits intrahepatic metastasis of orthotopically implanted murine hepatocellular carcinoma. causal interaction,unassigned 4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827071&form=6&db=m Identification of cis-acting promoter elements that support expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) in v-src transformed Madin-Darby canine kidney cells. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959855&form=6&db=m A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases. ongoing research,unassigned 2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594807&form=6&db=m Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12951464&form=6&db=m Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667142&form=6&db=m Coexpression of bone sialoprotein (BSP) and the pivotal transcriptional regulator of osteogenesis, Cbfa1/Runx2, in malignant melanoma. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670950&form=6&db=m Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14735469&form=6&db=m Expression profile of genes associated with antimetastatic gene: nm23-mediated metastasis inhibition in breast carcinoma cells. causal interaction,unassigned 1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172120&form=6&db=m (-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15351710&form=6&db=m Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381707&form=6&db=m The hemopexin domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) Is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15522170&form=6&db=m [Inhibitory effect of MT1-MMP antisense nucleotide on invasion of human highly metastatic ovarian cancer cell line SW626.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15563089&form=6&db=m [Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15819718&form=6&db=m Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15841326&form=6&db=m Membrane type 1-matrix metalloproteinase promotes human prostate cancer invasion and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16061633&form=6&db=m Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16419154&form=6&db=m Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525713&form=6&db=m Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619276&form=6&db=m Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778201&form=6&db=m Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979746&form=6&db=m Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18025272&form=6&db=m Inhibition of hepatocellular carcinoma invasion by suppression of claudin-10 in HLE cells. causal interaction,diagnostic usage,unassigned 1,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18089791&form=6&db=m Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions. causal interaction,unassigned 4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18661187&form=6&db=m A large-scale study of MT1-MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18665176&form=6&db=m MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19706774&form=6&db=m Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19820359&form=6&db=m Epidermal growth factor receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096316&form=6&db=m A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197470&form=6&db=m Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. causal interaction,unassigned 4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20529824&form=6&db=m Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20579139&form=6&db=m Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20721961&form=6&db=m Relation of MT1-MMP gene expression to outcomes in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20798051&form=6&db=m FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20823579&form=6&db=m Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21088866&form=6&db=m A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219645&form=6&db=m LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360607&form=6&db=m Looking at the proteases from a simple perspective. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21849471&form=6&db=m OXIDATIVE STRESS AND PROSTATE CANCER PROGRESSION ARE ELICITED BY MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP). causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22564723&form=6&db=m microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22791812&form=6&db=m c-Myc expression and MEK1-induced Erk2 nuclear localization are required for TGF-beta induced epithelial-mesenchymal transition and invasion in prostate cancer. causal interaction,unassigned 4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22842186&form=6&db=m In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines. causal interaction,unassigned 3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23202429&form=6&db=m miRNA-mRNA network detects hub mRNAs and cancer specific miRNAs in lung cancer. causal interaction,therapeutic application,unassigned 1,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23305265&form=6&db=m Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23314917&form=6&db=m Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548673&form=6&db=m Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23606746&form=6&db=m A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and three-dimensional invasion of macrophages. ongoing research,unassigned 3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23812425&form=6&db=m KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24012124&form=6&db=m CK2 inhibitor CX4945 induces sequential inactivation of proteins in the signaling pathways related with cell migration and suppresses metastasis of A549 human lung cancer cells. ongoing research,unassigned 3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24052388&form=6&db=m Genetically Encoded Fluorescent Biosensors for Live-Cell Imaging of MT1-MMP Protease Activity. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24202705&form=6&db=m NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24573354&form=6&db=m MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer. unassigned - 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24863849&form=6&db=m In vivo imaging of membrane type-1 matrix metalloproteinase with a novel activatable near-infrared fluorescence probe. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25241893&form=6&db=m NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. causal interaction,unassigned 1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25268950&form=6&db=m miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25552509&form=6&db=m [Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25592038&form=6&db=m Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748728&form=6&db=m Increased expression of MMP14 correlates with the poor prognosis of Chinese patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25808867&form=6&db=m MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma. ongoing research,unassigned 2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25818795&form=6&db=m [Effects of ?1-PDX, a furin inhibitor, on growth, invasion, and tumorigenicity of cervical cancer HeLa cells]. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25829357&form=6&db=m Matrix Metalloproteinase 14 Overexpression Is Correlated with the Progression and Poor Prognosis of Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26062348&form=6&db=m [Virtual screening and molecular simulations of antisense peptides targeting MT1-MMP]. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26107110&form=6&db=m RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathology. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26175856&form=6&db=m MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328493&form=6&db=m Radioiodinated Peptidic Imaging Probes for in Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26392417&form=6&db=m MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26541120&form=6&db=m Primary renal neuroblastoma with metastasis and matrix metalloproteinase-14 expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26610210&form=6&db=m MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail. causal interaction,unassigned 1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26867765&form=6&db=m UCA1 functions as a competing endogenous RNA to suppress epithelial ovarian cancer metastasis. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881932&form=6&db=m MT1-MMP Activation of TGF-? Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27096756&form=6&db=m Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27221755&form=6&db=m The membrane tethered matrix metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27526171&form=6&db=m MMP-14 Triggered Fluorescence Contrast Agent. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27562173&form=6&db=m Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27698891&form=6&db=m MMP-14 and TGF?-1 methylation in pituitary adenomas. causal interaction,unassigned 3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27835863&form=6&db=m Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27986919&form=6&db=m Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization. causal interaction,unassigned 4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28645305&form=6&db=m High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation. unassigned - 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28938563&form=6&db=m A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29136507&form=6&db=m Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis. causal interaction,unassigned 3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29379981&form=6&db=m TGF-?-induced NKILA inhibits ESCC cell migration and invasion through NF-?B/MMP14 signaling. unassigned - 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29556904&form=6&db=m Assessment of the MT1-MMP expression level of different cell lines by the naked eye. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29712618&form=6&db=m Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and ?1-integrin activation. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29970559&form=6&db=m Activated EphA2 Processing by MT1-MMP Is Involved in Malignant Transformation of Ovarian Tumours In Vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29986882&form=6&db=m Targeting the MMP-14/MMP-2/integrin ?v?3 axis with multispecific N-TIMP2-based antagonists for cancer therapy. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30065298&form=6&db=m Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30120968&form=6&db=m MMP14 predicts a poor prognosis in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30285791&form=6&db=m Molecular signature of response to preoperative radiotherapy in locally advanced breast cancer. unassigned - 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30350552&form=6&db=m Microsphere-Based Nanoindentation for the Monitoring of Cellular Cortical Stiffness Regulated by MT1-MMP. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30359513&form=6&db=m The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367951&form=6&db=m Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signalling in ovarian cancer. diagnostic usage,unassigned 1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30532247&form=6&db=m High serum MMP-14 predicts worse survival in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30592555&form=6&db=m Reducing proteolytic liability of a MMP-14 inhibitory antibody by site-saturation mutagenesis. causal interaction,unassigned 3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641935&form=6&db=m Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30986050&form=6&db=m Screening, Identification, and Characterization of an Affinity Peptide Specific to MT1-MMP and Its Application in Tumor Imaging. diagnostic usage,unassigned 3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31519727&form=6&db=m MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma membrane. causal interaction,unassigned 3,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31560170&form=6&db=m High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31810492&form=6&db=m DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32210086&form=6&db=m MeCP2 Promotes Colorectal Cancer Metastasis by Modulating ZEB1 Transcription. causal interaction,diagnostic usage,unassigned 2,2,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32522804&form=6&db=m Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633349&form=6&db=m High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33267897&form=6&db=m HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33552276&form=6&db=m Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2? in osteosarcoma and prostate carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34114806&form=6&db=m Noninvasive Bioluminescence Imaging of Matrix Metalloproteinase-14 Activity in Lung Cancer Using a Membrane-Bound Biosensor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34229297&form=6&db=m Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis. causal interaction,unassigned 1,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397867&form=6&db=m Prognostic targets recognition of rectal adenocarcinoma based on transcriptomics. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397871&form=6&db=m Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.80 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531530&form=6&db=m TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7630026&form=6&db=m [Expression of membrane-type matrix metalloproteinase (MT-MMP) and activation of MMP-2 in lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8743942&form=6&db=m MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis. ongoing research,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8882706&form=6&db=m Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasis. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8938135&form=6&db=m Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8999957&form=6&db=m Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9092941&form=6&db=m Identification of the membrane-type matrix metalloproteinase MT1-MMP in osteoclasts. ongoing research,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9098015&form=6&db=m Relation of enhanced secretion of active matrix metalloproteinases with tumor spread in human hepatocellular carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9180929&form=6&db=m Metastatic ability of MXT mouse mammary subpopulations correlates with clonal expression and/or membrane-association of gelatinase A. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9221811&form=6&db=m Analysis of MT1-MMP and MMP2 expression in human gastric cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9410885&form=6&db=m Matrix metalloproteinase-2 activation modulates glioma cell migration. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9413149&form=6&db=m Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9482695&form=6&db=m Expression of membrane-type matrix metalloproteinase in rabbit neointimal tissue and its correlation with matrix-metalloproteinase-2 activation. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9548812&form=6&db=m Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9610608&form=6&db=m Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9654189&form=6&db=m Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9685743&form=6&db=m Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9706143&form=6&db=m Activation of tumor cell matrix metalloproteinase-2 by neutrophil proteinases requires expression of membrane-type 1 matrix metalloproteinase. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9721888&form=6&db=m Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9921997&form=6&db=m Membrane-type matrix metalloproteinase-1 expression and activation of gelatinase A as prognostic markers in advanced pediatric neuroblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9933692&form=6&db=m Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027405&form=6&db=m Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10208467&form=6&db=m Increased expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 with tumor dedifferentiation in hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10383907&form=6&db=m Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411101&form=6&db=m Overexpression of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in metastatic MDCK cells transformed by v-src. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10415735&form=6&db=m Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials. ongoing research,therapeutic application,unassigned 2,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473866&form=6&db=m Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10548512&form=6&db=m Heat shock suppresses membrane type 1-matrix metalloproteinase production and progelatinase A activation in human fibrosarcoma HT-1080 cells and thereby inhibits cellular invasion. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600499&form=6&db=m Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display library. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632347&form=6&db=m Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10658069&form=6&db=m Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728589&form=6&db=m Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10733122&form=6&db=m Membrane-type 1 matrix metalloproteinase mRNA expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10753951&form=6&db=m Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell lines. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10780674&form=6&db=m AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861469&form=6&db=m Activation of fibroblast-derived matrix metalloproteinase-2 by colon-cancer cells in non-contact Co-cultures. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10914717&form=6&db=m Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10998420&form=6&db=m Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11171051&form=6&db=m Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11221894&form=6&db=m Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11232638&form=6&db=m Down-Regulation of MT1-MMP expression by the alpha3 chain of type IV collagen inhibits bronchial tumor cell line invasion. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235952&form=6&db=m Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235988&form=6&db=m Heat shock-mediated transient increase in intracellular 3',5'-cyclic AMP results in tumor specific suppression of membrane type 1-matrix metalloproteinase production and progelatinase A activation. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297247&form=6&db=m Ets-1 messenger RNA expression is a novel marker of poor survival in ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11355270&form=6&db=m MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11381077&form=6&db=m Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. causal interaction,ongoing research,unassigned 2,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11517338&form=6&db=m Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11564733&form=6&db=m Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-kappa B-mediated induction of membrane type 1 matrix metalloproteinase in murine melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11571719&form=6&db=m Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11741954&form=6&db=m An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751414&form=6&db=m Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11756481&form=6&db=m Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11757910&form=6&db=m Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) mRNA in trophoblast and endometrial epithelial cell populations of the synepitheliochorial placenta of goats (Capra hircus). causal interaction,ongoing research,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11773076&form=6&db=m The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11817712&form=6&db=m Effects of 17beta-estradiol on the expression of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-2 in human osteoblastic MG-63 cell cultures. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827071&form=6&db=m Identification of cis-acting promoter elements that support expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) in v-src transformed Madin-Darby canine kidney cells. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11848101&form=6&db=m Two-step sandwich enzyme immunoassay using monoclonal antibodies for detection of soluble and membrane-associated human membrane type 1-matrix metalloproteinase. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857380&form=6&db=m Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11869527&form=6&db=m [Expression of membrane-type I matrix metalloproteinase and its correlation with gelatinase A activation in cancer cell lines] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11918701&form=6&db=m Membrane type 1 matrix metalloproteinase regulates cellular invasiveness and survival in cutaneous epidermal cells. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959855&form=6&db=m A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases. ongoing research,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12006939&form=6&db=m Increased membrane type 1 matrix metalloproteinase expression from adenoma to colon cancer: a possible mechanism of neoplastic progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12056775&form=6&db=m Expression of matrix metalloprotease-2 (MMP-2) and the activator membrane type 1 (MT1-MMP) in canine mammary carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12145196&form=6&db=m CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. ongoing research,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12366815&form=6&db=m Case of primary malignant hemangiopericytoma of the heart expressing basement membrane-degradable enzymes. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12473670&form=6&db=m Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha /IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. therapeutic application,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12480917&form=6&db=m Rapid trafficking of membrane type 1-matrix metalloproteinase to the cell surface regulates progelatinase a activation. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488433&form=6&db=m The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12514192&form=6&db=m Membrane type-1 matrix metalloproteinase functions as a proprotein self-convertase. Expression of the latent zymogen in Pichia pastoris, autolytic activation, and the peptide sequence of the cleavage forms. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594807&form=6&db=m Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606436&form=6&db=m Differential regulation of the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases by cytokines and growth factors in bovine endometrial stromal cells and trophoblast cell line BT-1 in vitro. ongoing research,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631625&form=6&db=m Interleukin 10 blocks matrix metalloproteinase-2 and membrane type 1-matrix metalloproteinase synthesis in primary human prostate tumor lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706853&form=6&db=m Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12714042&form=6&db=m Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis. causal interaction,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12784992&form=6&db=m Role of pericellular proteolysis by membrane-type 1 matrix metalloproteinase in cancer invasion and angiogenesis. causal interaction,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12841863&form=6&db=m Roles of pericellular proteolysis by membrane type-1 matrix metalloproteinase in cancer invasion and angiogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12859896&form=6&db=m Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12951464&form=6&db=m Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14582707&form=6&db=m A study on angiogenesis-related matrix metalloproteinase networks in primary hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14639619&form=6&db=m Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14647466&form=6&db=m Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667142&form=6&db=m Coexpression of bone sialoprotein (BSP) and the pivotal transcriptional regulator of osteogenesis, Cbfa1/Runx2, in malignant melanoma. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670950&form=6&db=m Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691052&form=6&db=m Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14718544&form=6&db=m Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729679&form=6&db=m Up-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760014&form=6&db=m Limited processing of pro-matrix metalloprotease-2 (gelatinase A) overexpressed by transfection in PC-3 human prostate tumor cells: association with restricted cell surface localization of membrane-type matrix metalloproteinase-1. ongoing research,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15118611&form=6&db=m Functional role of matrix metalloproteinases in ovarian tumor cell plasticity. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172120&form=6&db=m (-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15208686&form=6&db=m Functional role of MIA in melanocytes and early development of melanoma. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15260832&form=6&db=m Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313864&form=6&db=m Expression of proteolytic enzymes in head and neck cancer-associated fibroblasts. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15351710&form=6&db=m Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381670&form=6&db=m Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381707&form=6&db=m The hemopexin domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) Is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466200&form=6&db=m Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15522170&form=6&db=m [Inhibitory effect of MT1-MMP antisense nucleotide on invasion of human highly metastatic ovarian cancer cell line SW626.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15558018&form=6&db=m CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15563089&form=6&db=m [Gene expression of matrix mettallo-proteinase 14 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592504&form=6&db=m Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15729288&form=6&db=m Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743799&form=6&db=m Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15819718&form=6&db=m Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878869&form=6&db=m Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944163&form=6&db=m Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16046398&form=6&db=m Potent mechanism-based inhibitors for matrix metalloproteinases. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16061633&form=6&db=m Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16093431&form=6&db=m Competitive disruption of the tumor-promoting function of membrane type 1 matrix metalloproteinase/matrix metalloproteinase-14 in vivo. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391876&form=6&db=m Down-regulation of MT1-MMP expression suppresses tumor cell invasion in metastatic human SW626 ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16470875&form=6&db=m Matrix metalloproteases in head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525713&form=6&db=m Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619276&form=6&db=m Predictive value of laminin-5 and membrane type 1-matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16636666&form=6&db=m Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16644105&form=6&db=m A conjugate of camptothecin and a somatostatin analog against prostate cancer cell invasion via a possible signaling pathway involving PI3K/Akt, alphaVbeta3/alphaVbeta5 and MMP-2/-9. causal interaction,therapeutic application,unassigned 3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16696335&form=6&db=m Construction of antisense MT1-MMP vector and its inhibitory effects on invasion of human ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778201&form=6&db=m Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849548&form=6&db=m Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16940151&form=6&db=m Mechanistic insights into targeting T cell membrane proteinase to promote islet beta-cell rejuvenation in type 1 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979746&form=6&db=m Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050542&form=6&db=m Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells. ongoing research,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17079467&form=6&db=m Membrane type-1 matrix metalloproteinase confers aneuploidy and tumorigenicity on mammary epithelial cells. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17140440&form=6&db=m Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210685&form=6&db=m Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17245132&form=6&db=m Proteolysis-driven oncogenesis. ongoing research,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17257129&form=6&db=m The clinicopathological and prognostic significance of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-9 according to their localization in invasive breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17365174&form=6&db=m Defining the roles of T cell membrane proteinase and CD44 in type 1 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17389600&form=6&db=m Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17446312&form=6&db=m Prostate Cancer-Associated Membrane Type 1-Matrix Metalloproteinase. A Pivotal Role in Bone Response and Intraosseous Tumor Growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17473445&form=6&db=m In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP). causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483344&form=6&db=m Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525276&form=6&db=m Prostate cancer-associated membrane type 1-matrix metalloproteinase: a pivotal role in bone response and intraosseous tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17534446&form=6&db=m Membrane-type 1 matrix metalloproteinase is regulated by sp1 through the differential activation of AKT, JNK, and ERK pathways in human prostate tumor cells. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17541067&form=6&db=m Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17583453&form=6&db=m Tumor targeting of doxorubicin by anti-MT1-MMP antibody-modified PEG liposomes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609667&form=6&db=m MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640303&form=6&db=m Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17938169&form=6&db=m Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18065811&form=6&db=m Tetra- and hexavalent mannosides inhibit the pro-apoptotic, antiproliferative and cell surface clustering effects of concanavalin-A: impact on MT1-MMP functions in marrow-derived mesenchymal stromal cells. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071307&form=6&db=m MT1-MMP is required for efficient tumor dissemination in experimental metastatic disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18089791&form=6&db=m Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18301992&form=6&db=m Human breast adenocarcinoma (MDA-231) and human lung squamous cell carcinoma (Hara) do not have the ability to cause bone resorption by themselves during the establishment of bone metastasis. ongoing research,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18392131&form=6&db=m A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18423448&form=6&db=m Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18441011&form=6&db=m Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18492850&form=6&db=m Gene expression ratio stability evaluation in prepubertal bovine mammary tissue from calves fed different milk replacers reveals novel internal controls for quantitative polymerase chain reaction. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18521441&form=6&db=m Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18621108&form=6&db=m Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18621744&form=6&db=m Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18665176&form=6&db=m MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18716553&form=6&db=m Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18927121&form=6&db=m Characterization of the transcriptional regulation of the human MT1-MMP gene and association of risk reduction for focal-segmental glomerulosclerosis with two functional promoter SNPs. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18971959&form=6&db=m ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18976802&form=6&db=m Expression of membrane type 1 matrix metalloproteinase (MMP-14) in epithelial ovarian cancer: high level expression in clear cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19023892&form=6&db=m Polarized MT1-MMP-CD44 interaction and CD44 cleavage during cell retraction reveal an essential role for MT1-MMP in CD44-mediated invasion. ongoing research,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109023&form=6&db=m Development of an optimized activatable MMP-14 targeted SPECT imaging probe. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19136391&form=6&db=m Increased Aggressiveness of Human Prostate PC-3 Tumor Cells Expressing Cell Surface Localized Membrane Type-1 Matrix Metalloproteinase (MT1-MMP). diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208838&form=6&db=m Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19211836&form=6&db=m Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. causal interaction,ongoing research,unassigned 1,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218449&form=6&db=m Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232058&form=6&db=m Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells. therapeutic application,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19243022&form=6&db=m Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19406172&form=6&db=m Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409422&form=6&db=m Emerging concepts in the regulation of membrane-type 1 matrix metalloproteinase activity. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19458085&form=6&db=m Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19515020&form=6&db=m Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts. ongoing research,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536854&form=6&db=m Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19571397&form=6&db=m Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19654316&form=6&db=m A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion. causal interaction,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19753302&form=6&db=m Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19820359&form=6&db=m Epidermal growth factor receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19855192&form=6&db=m A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19961596&form=6&db=m Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096316&form=6&db=m A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20148894&form=6&db=m Coordinate action of membrane-type matrix metalloproteinase -1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197385&form=6&db=m CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling. causal interaction,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197470&form=6&db=m Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20208009&form=6&db=m The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20424116&form=6&db=m Matrix Metalloproteinase-14 (MT1-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis. causal interaction,therapeutic application,unassigned 3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20432456&form=6&db=m Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20471961&form=6&db=m MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20486866&form=6&db=m Metalloproteinase binding proteins: WO2009097397. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20525764&form=6&db=m Insulin receptor substrate 1 regulates the cellular differentiation and the matrix metallopeptidase expression of preosteoblastic cells. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20529824&form=6&db=m Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20579139&form=6&db=m Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20587521&form=6&db=m Membrane type 1-matrix metalloproteinase cleaves off the NH2-terminal portion of heparin-binding epidermal growth factor and converts it into a heparin-independent growth factor. causal interaction,ongoing research,unassigned 2,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20605790&form=6&db=m Rho-ROCK-myosin signaling mediates membrane type 1 matrix metalloproteinase-induced cellular aggregation of keratinocytes. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20605791&form=6&db=m Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase. diagnostic usage,ongoing research,unassigned 2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651331&form=6&db=m Inhibition of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation blocks tumor progression in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20663911&form=6&db=m Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20666777&form=6&db=m GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. causal interaction,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20721961&form=6&db=m Relation of MT1-MMP gene expression to outcomes in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20798051&form=6&db=m FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20823579&form=6&db=m Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20837484&form=6&db=m The Wnt/planar cell polarity (PCP) protein tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase (MT1-MMP): implications in cancer and embryogenesis. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20854210&form=6&db=m Membrane type 1 matrix metalloproteinase detection in tumors, using the iodinated endogenous [123I]-tissue inhibitor 2 of metalloproteinases as imaging agent. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876804&form=6&db=m Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20946474&form=6&db=m Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21088866&form=6&db=m A role for MT1-MMP as a cell death sensor/effector through the regulation of endoplasmic reticulum stress in U87 glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21240464&form=6&db=m Effects of bevacizumab in mouse model of endometrial cancer: Defining the molecular basis for resistance. causal interaction,therapeutic application,unassigned 1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21324352&form=6&db=m Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21339346&form=6&db=m Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360607&form=6&db=m Looking at the proteases from a simple perspective. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21718387&form=6&db=m Development of membrane type-1 matrix metalloproteinase-specific activatable fluorescent probe for malignant tumor detection. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21795678&form=6&db=m Inhibition of matrix metalloproteinase-14 (MMP-14)-mediated cancer cell migration. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801067&form=6&db=m Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21849471&form=6&db=m OXIDATIVE STRESS AND PROSTATE CANCER PROGRESSION ARE ELICITED BY MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP). causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002060&form=6&db=m Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22406620&form=6&db=m Novel MT1-MMP small molecule inhibitors based on insights into hemopexin domain function in tumor growth. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22527983&form=6&db=m Single-nucleotide polymorphisms and haplotypes of membrane type 1-matrix metalloproteinase in susceptibility and clinical significance of squamous cell neoplasia of uterine cervix in taiwan women. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22637745&form=6&db=m Re-expression of miR-200 by novel approaches regulates the expression of PTEN and MT1-MMP in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22679501&form=6&db=m Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22918226&form=6&db=m Potentially Novel Candidate Biomarkers for Head and Neck Squamous Cell Carcinoma Identified Using an Integrated Cell Line-based Discovery Strategy. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22922740&form=6&db=m Enhanced membrane-type 1 matrix metalloproteinase expression by hyaluronan oligosaccharides in breast cancer cells facilitates CD44 cleavage and tumor cell migration. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23202429&form=6&db=m miRNA-mRNA network detects hub mRNAs and cancer specific miRNAs in lung cancer. causal interaction,therapeutic application,unassigned 1,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23250208&form=6&db=m Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin ?1. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23266860&form=6&db=m Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells. ongoing research,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23305265&form=6&db=m Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23314917&form=6&db=m Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23346765&form=6&db=m Reduction in tumour cell invasion by pigment epithelium-derived factor is mediated by membrane type-1 matrix metalloproteinase downregulation. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23354307&form=6&db=m Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357422&form=6&db=m N-Acetylglucosaminyltransferase V triggers overexpression of MT1-MMP and reinforces the invasive/metastatic potential of cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23409034&form=6&db=m Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23439492&form=6&db=m CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells. causal interaction,ongoing research,unassigned 3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548172&form=6&db=m Membrane Type 1 Matrix Metalloproteinase induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548673&form=6&db=m Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23606746&form=6&db=m A specific subset of RabGTPases controls cell surface exposure of MT1-MMP, extracellular matrix degradation and three-dimensional invasion of macrophages. ongoing research,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23733191&form=6&db=m Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23804419&form=6&db=m Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time. ongoing research,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24052388&form=6&db=m Genetically Encoded Fluorescent Biosensors for Live-Cell Imaging of MT1-MMP Protease Activity. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24156018&form=6&db=m Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24202705&form=6&db=m NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24213464&form=6&db=m Membrane Type-1 Matrix Metalloproteinase Expression in Acute Myeloid Leukemia and Its Upregulation by Tumor Necrosis Factor-?. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24297057&form=6&db=m Localized surface plasmon resonance based nanobiosensor for biomarker detection of invasive cancer cells. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24489925&form=6&db=m The role of matrix metalloproteinase in the intimal sarcoma-like cells derived from endarterectomized tissues from a chronic thromboembolic pulmonary hypertension patient. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24583688&form=6&db=m Molecular recognition of proteolytic activity in metastatic cancer cells using fluorogenic gold nanoprobes. ongoing research,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24641451&form=6&db=m Tumor-Targeted Prodrug ICT2588 Demonstrates Therapeutic Activity against Solid Tumors and Reduced Potential for Cardiovascular Toxicity. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24657728&form=6&db=m The emerging role of MMP14 in brain tumorigenesis and future therapeutics. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24807903&form=6&db=m SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion. ongoing research,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24863849&form=6&db=m In vivo imaging of membrane type-1 matrix metalloproteinase with a novel activatable near-infrared fluorescence probe. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24986569&form=6&db=m MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24989798&form=6&db=m Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25006253&form=6&db=m Protein-tyrosine Pseudokinase 7 (PTK7) Directs Cancer Cell Motility and Metastasis. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25062266&form=6&db=m Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25091190&form=6&db=m Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25241893&form=6&db=m NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer. causal interaction,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25268950&form=6&db=m miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25552509&form=6&db=m [Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25681867&form=6&db=m On the move: endocytic trafficking in cell migration. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25682387&form=6&db=m Orthotopic non-metastatic and metastatic oral cancer mouse models. causal interaction,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748728&form=6&db=m Increased expression of MMP14 correlates with the poor prognosis of Chinese patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25755834&form=6&db=m The overexpression membrane type 1 matrix metalloproteinase is associated with the progression and prognosis in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25774665&form=6&db=m A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25829357&form=6&db=m Matrix Metalloproteinase 14 Overexpression Is Correlated with the Progression and Poor Prognosis of Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25851348&form=6&db=m Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25977338&form=6&db=m miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26001294&form=6&db=m p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040767&form=6&db=m A role of MMP-14 in the regulation of invasiveness of nasopharyngeal carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26047679&form=6&db=m miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26052095&form=6&db=m MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26062348&form=6&db=m [Virtual screening and molecular simulations of antisense peptides targeting MT1-MMP]. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26078788&form=6&db=m Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097538&form=6&db=m Expression of MMP14 in invasive pituitary adenomas: relationship to invasion and angiogenesis. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26106602&form=6&db=m Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26107110&form=6&db=m RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathology. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26175856&form=6&db=m MMP14 regulates cell migration and invasion through epithelial-mesenchymal transition in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26289026&form=6&db=m MT1-MMP recognition by ERM proteins and its implication in CD44 shedding. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26315469&form=6&db=m Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328493&form=6&db=m Radioiodinated Peptidic Imaging Probes for in Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26364240&form=6&db=m Significance of caveolin-1 and matrix metalloproteinase 14 gene expression in canine mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464124&form=6&db=m Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-?B pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26504163&form=6&db=m MT1-MMP: Endosomal delivery drives breast cancer metastasis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26504170&form=6&db=m ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26513555&form=6&db=m MMP14 as a novel downstream target of VEGFR2 in migratory glioma-tropic neural stem cells. therapeutic application,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26578437&form=6&db=m Development of PEGylated peptide probes conjugated with (18)F-labeled BODIPY for PET/optical imaging of MT1-MMP activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26589794&form=6&db=m Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by G?13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling. causal interaction,ongoing research,unassigned 1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26610210&form=6&db=m MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail. causal interaction,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26636948&form=6&db=m Pressure and Temperature Effects on the Activity and Structure of the Catalytic Domain of Human MT1-MMP. causal interaction,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881932&form=6&db=m MT1-MMP Activation of TGF-? Signaling Enables Intercellular Activation of an Epithelial-mesenchymal Transition Program in Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26916665&form=6&db=m Membrane type 1-matrix metalloproteinase induces epithelial-to-mesenchymal transition in esophageal squamous cell carcinoma: Observations from clinical and in vitro analyses. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27056569&form=6&db=m Immunohistochemical demonstration of EphA2 processing by MT1-MMP in invasive cutaneous squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27096756&form=6&db=m Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27154818&form=6&db=m miR-150-5p and miR-133a suppress glioma cell proliferation and migration through targeting membrane-type-1 matrix metalloproteinase. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270613&form=6&db=m NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-?B pathway. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27402208&form=6&db=m A new front in cell invasion: The invadopodial membrane. ongoing research,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27462980&form=6&db=m Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27526171&form=6&db=m MMP-14 Triggered Fluorescence Contrast Agent. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27531896&form=6&db=m Interleukin-6 increases matrix metalloproteinase-14 (MMP-14) levels via down-regulation of p53 to drive cancer progression. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27562173&form=6&db=m Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27564100&form=6&db=m Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22. causal interaction,diagnostic usage,unassigned 1,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27698891&form=6&db=m MMP-14 and TGF?-1 methylation in pituitary adenomas. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27864359&form=6&db=m Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B. diagnostic usage,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27965386&form=6&db=m Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries. diagnostic usage,therapeutic application,unassigned 1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27986919&form=6&db=m Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28013056&form=6&db=m Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28186971&form=6&db=m Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition. ongoing research,therapeutic application,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28267240&form=6&db=m Integrated functions of membrane-type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28270508&form=6&db=m Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28270983&form=6&db=m Clinically compatible flexible wide-field multi-color fluorescence endoscopy with a porcine colon model. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28281307&form=6&db=m Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia. ongoing research,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28318921&form=6&db=m Influence of TGF-?1 on tumor transition in oral cancer cell and BMSC co-cultures. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28498893&form=6&db=m Role of DHX33 in c-Myc-induced cancers. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634425&form=6&db=m A Transcriptional Regulatory Role for the Membrane Type-1 Matrix Metalloproteinase in Carcinogen-Induced Inflammasome Gene Expression. ongoing research,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28918236&form=6&db=m Gene expression profiles of cell adhesion molecules, matrix metalloproteinases and their tissue inhibitors in canine oral tumors. causal interaction,diagnostic usage,unassigned 3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28938563&form=6&db=m A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models. causal interaction,therapeutic application,unassigned 4,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29050494&form=6&db=m Whole transcriptome analysis identifies differentially regulated networks between osteosarcoma and normal bone samples. diagnostic usage,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29072678&form=6&db=m Specific detection of soluble EphA2 fragments in blood as a new biomarker for pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29136499&form=6&db=m Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries. ongoing research,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29136507&form=6&db=m Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29286099&form=6&db=m Downregulation of matrix metalloproteinase 14 by the antitumor miRNA, miR-150-5p, inhibits the aggressiveness of lung squamous cell carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29318540&form=6&db=m Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29393353&form=6&db=m Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29420334&form=6&db=m Immunogenicity moderation effect of interleukin-24 on myelogenous leukemia cells. ongoing research,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552138&form=6&db=m Association of BCSC-1 and MMP-14 with human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29556904&form=6&db=m Assessment of the MT1-MMP expression level of different cell lines by the naked eye. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29575776&form=6&db=m Quantitative Analysis of Multiple Proteins of Different Invasive Tumor Cell Lines at the Same Single-Cell Level. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29934628&form=6&db=m PROX1 is a transcriptional regulator of MMP14. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29935194&form=6&db=m Matrix metalloproteinase-14 induces epithelial-to-mesenchymal transition in synovial sarcoma. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29986882&form=6&db=m Targeting the MMP-14/MMP-2/integrin ?v?3 axis with multispecific N-TIMP2-based antagonists for cancer therapy. causal interaction,ongoing research,unassigned 2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30065298&form=6&db=m Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116394&form=6&db=m Effects of CoCl2-simulated hypoxia on the expression levels of matrix metalloproteinases in renal adenocarcinoma cells and renal tubular epithelial cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30120968&form=6&db=m MMP14 predicts a poor prognosis in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30352172&form=6&db=m Hijacking a Morphogenesis Proteinase for Cancer Cell Invasion. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355924&form=6&db=m The Effects of miR-195-5p/MMP14 on Proliferation and Invasion of Cervical Carcinoma Cells Through TNF Signaling Pathway Based on Bioinformatics Analysis of Microarray Profiling. therapeutic application,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30359513&form=6&db=m The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30471921&form=6&db=m MT1-MMP Binds Membranes by Opposite Tips of Its ? Propeller to Position It for Pericellular Proteolysis. ongoing research,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30521382&form=6&db=m MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30591440&form=6&db=m Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30592555&form=6&db=m Reducing proteolytic liability of a MMP-14 inhibitory antibody by site-saturation mutagenesis. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30606769&form=6&db=m Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress. causal interaction,unassigned 4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30986050&form=6&db=m Screening, Identification, and Characterization of an Affinity Peptide Specific to MT1-MMP and Its Application in Tumor Imaging. diagnostic usage,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31011632&form=6&db=m Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31137480&form=6&db=m The Expanding Role of MT1-MMP in Cancer Progression. diagnostic usage,therapeutic application,unassigned 4,3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31208977&form=6&db=m Translocating a High-Affinity Designer TIMP-1 to the Cell Membrane for Total Renal Carcinoma Inhibition: Putting the Prion Protein to Good Use. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31289496&form=6&db=m A DNA aptamer recognizing MMP14 for in vivo and in vitro imaging identified by cell-SELEX. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31466240&form=6&db=m MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31560170&form=6&db=m High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677819&form=6&db=m CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells. ongoing research,therapeutic application,unassigned 2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31689484&form=6&db=m Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. causal interaction,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31810492&form=6&db=m DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31956360&form=6&db=m Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32015228&form=6&db=m How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32015230&form=6&db=m Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice. therapeutic application,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32122646&form=6&db=m High MMP14 expression is predictive of poor prognosis in resectable hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32390382&form=6&db=m Prognostic Significance of Matrix Metalloproteinase 14 in Patients with Cancer: a Systematic Review and Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32522804&form=6&db=m Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633349&form=6&db=m High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32694700&form=6&db=m Cancer cells grown in 3D under fluid flow exhibit an aggressive phenotype and reduced responsiveness to the anti-cancer treatment doxorubicin. diagnostic usage,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32819585&form=6&db=m Membrane type 1 matrix metalloproteinase regulates anaplastic thyroid carcinoma cell growth and invasion into the collagen matrix. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848463&form=6&db=m microRNA-26a Directly Targeting MMP14 and MMP16 Inhibits the Cancer Cell Proliferation, Migration and Invasion in Cutaneous Squamous Cell Carcinoma. unassigned - 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32872536&form=6&db=m Neoplastic Cells are the Major Source of MT-MMPs in IDH1-Mutant Glioma, Thus Enhancing Tumor-Cell Intrinsic Brain Infiltration. causal interaction,unassigned 2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32930509&form=6&db=m Matrix metalloproteinase-14 (MMP-14) downregulation inhibits esophageal squamous cell carcinoma cell migration, invasion, and proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32974187&form=6&db=m Matrix Metallopeptidase 14: A Candidate Prognostic Biomarker for Diffuse Large B-Cell Lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33015947&form=6&db=m Rapid Unperturbed-Tissue Analysis for Intraoperative Cancer Diagnosis Using an Enzyme-Activated NIR-II Nanoprobe. diagnostic usage,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727629&form=6&db=m Genetic association of MMP14 promoter variants and their functional significance in gallbladder cancer pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33924099&form=6&db=m Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth. causal interaction,therapeutic application,unassigned 1,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33990548&form=6&db=m Monocytic MDSC mobilization promotes tumor recurrence after liver transplantation via CXCL10/TLR4/MMP14 signaling. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34012098&form=6&db=m Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34114806&form=6&db=m Noninvasive Bioluminescence Imaging of Matrix Metalloproteinase-14 Activity in Lung Cancer Using a Membrane-Bound Biosensor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34229297&form=6&db=m Chloride intracellular channel protein 2 is secreted and inhibits MMP14 activity, while preventing tumor cell invasion and metastasis. causal interaction,unassigned 1,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34381878&form=6&db=m TGF-?1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells. causal interaction,unassigned 3,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397867&form=6&db=m Prognostic targets recognition of rectal adenocarcinoma based on transcriptomics. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397871&form=6&db=m Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.80 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34517516&form=6&db=m Bioinformatics analysis identified MMP14 and COL12A1 as immune-related biomarkers associated with pancreatic adenocarcinoma prognosis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Nephrosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24136919&form=6&db=m Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27833045&form=6&db=m Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9921997&form=6&db=m Membrane-type matrix metalloproteinase-1 expression and activation of gelatinase A as prognostic markers in advanced pediatric neuroblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19961596&form=6&db=m Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20579139&form=6&db=m Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22564723&form=6&db=m microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24399074&form=6&db=m Vandetanib-induced inhibition of neuroblastoma cell migration and invasion is associated with downregulation of the SDF-1/CXCR4 axis and matrix metalloproteinase 14. causal interaction,unassigned 4,0 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25592038&form=6&db=m Hepatocyte nuclear factor 4 alpha promotes the invasion, metastasis and angiogenesis of neuroblastoma cells via targeting matrix metalloproteinase 14. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26047679&form=6&db=m miRNA-584-5p exerts tumor suppressive functions in human neuroblastoma through repressing transcription of matrix metalloproteinase 14. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26084291&form=6&db=m miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26541120&form=6&db=m Primary renal neuroblastoma with metastasis and matrix metalloproteinase-14 expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33015947&form=6&db=m Rapid Unperturbed-Tissue Analysis for Intraoperative Cancer Diagnosis Using an Enzyme-Activated NIR-II Nanoprobe. diagnostic usage,unassigned 1,0 3.4.24.80 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34107282&form=6&db=m Matrix metalloproteinase 14 regulates HSV-1 infection in neuroblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 3.4.24.80 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18621108&form=6&db=m Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. causal interaction,unassigned 3,0 3.4.24.80 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16829852&form=6&db=m Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.4.24.80 Newcastle Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33090092&form=6&db=m Matrix metalloproteinase-14 regulates collagen degradation and migration of mononuclear cells during infection with genotype VII Newcastle disease virus. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.4.24.80 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660624&form=6&db=m Genetic link between obesity and MMP14-dependent adipogenic collagen turnover. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1 3.4.24.80 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24243641&form=6&db=m A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome. causal interaction,unassigned 3,0 3.4.24.80 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26451282&form=6&db=m Obesity-induced remodeling of the adipose tissue elastin network is independent of the metalloelastase MMP-12. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.24.80 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31988105&form=6&db=m The critical role of MMP14 in adipose tissue remodeling during obesity. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32614494&form=6&db=m Matrix metalloproteinase 15 plays a pivotal role in human first trimester cytotrophoblast invasion and is not altered by maternal obesity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 3.4.24.80 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26945816&form=6&db=m Peripheral osteolysis in adults linked to ASAH1 (acid ceramidase) mutations: A new presentation of Farber disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 3.4.24.80 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28675805&form=6&db=m Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders. causal interaction,diagnostic usage,unassigned 2,3,0 3.4.24.80 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22678797&form=6&db=m [Association of MMP14 gene polymorphisms and osteoporosis in Zhuang men from Baise region of Guangxi]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.4.24.80 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31638569&form=6&db=m [Progranulin aggravates postmenopausal osteoporosis in ovariectomized mice]. diagnostic usage,unassigned 2,0 3.4.24.80 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12842447&form=6&db=m Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 3.4.24.80 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16327977&form=6&db=m Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 3.4.24.80 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33552276&form=6&db=m Co-localisation of intra-nuclear membrane type-1 matrix metalloproteinase and hypoxia inducible factor-2? in osteosarcoma and prostate carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11063654&form=6&db=m Expression of various matrix proteases and Ets family transcriptional factors in ovarian cancer cell lines: correlation to invasive potential. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306508&form=6&db=m Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells. causal interaction,ongoing research,unassigned 3,3,0 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15118611&form=6&db=m Functional role of matrix metalloproteinases in ovarian tumor cell plasticity. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19028702&form=6&db=m Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19706774&form=6&db=m Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21176152&form=6&db=m Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23597851&form=6&db=m New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy. diagnostic usage,therapeutic application,unassigned 3,4,0 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24603589&form=6&db=m Visual and automated assessment of matrix metalloproteinase-14 tissue expression for the evaluation of ovarian cancer prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25205731&form=6&db=m Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium. ongoing research,unassigned 4,0 3.4.24.80 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28655772&form=6&db=m Post-translational modification of the membrane type 1 matrix metalloproteinase (MT1-MMP) cytoplasmic tail impacts ovarian cancer multicellular aggregate dynamics. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.80 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21057545&form=6&db=m Collagen regulation of let-7 in pancreatic cancer involves TGF-?1-mediated membrane type 1-matrix metalloproteinase expression. causal interaction,unassigned 4,0 3.4.24.80 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21288898&form=6&db=m Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion. causal interaction,unassigned 2,0 3.4.24.80 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038627&form=6&db=m The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells. causal interaction,unassigned 3,0 3.4.24.80 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22232555&form=6&db=m Interplay between ?1-Integrin and Rho Signaling Regulates Differential Scattering and Motility of Pancreatic Cancer Cells by Snail and Slug Proteins. causal interaction,unassigned 3,0 3.4.24.80 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633349&form=6&db=m High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32950968&form=6&db=m Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 3.4.24.80 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094925&form=6&db=m Bioinformatics Analysis of a Prognostic miRNA Signature and Potential Key Genes in Pancreatic Cancer. ongoing research,therapeutic application,unassigned 1,1,0 3.4.24.80 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961487&form=6&db=m Long-term overexpression of membrane type-1 matrix metalloproteinase and matrix metalloproteinase-2 in oleic acid-induced pancreatitis in rats. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25091190&form=6&db=m Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.24.80 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21826658&form=6&db=m Sequential IL-23 and IL-17 and increased Mmp8 and Mmp14 expression characterize the progression of an experimental model of periodontal disease in type 1 diabetes. ongoing research,unassigned 1,0 3.4.24.80 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233321&form=6&db=m Involvement of MT1-MMP and TIMP-2 in human periodontal disease. ongoing research,unassigned 4,0 3.4.24.80 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26793622&form=6&db=m A Systems Biology Approach to Reveal Putative Host-Derived Biomarkers of Periodontitis by Network Topology Characterization of MMP-REDOX/NO and Apoptosis Integrated Pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.4.24.80 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34041892&form=6&db=m [The significance of the expression of matrix metalloproteinases in the differential diagnosis of periodontal diseases]. causal interaction,diagnostic usage,unassigned 3,4,0 3.4.24.80 Peripheral Arterial Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22123215&form=6&db=m Number of endothelial progenitor cells in peripheral artery disease as a marker of severity and association with pentraxin-3, malondialdehyde-modified low-density lipoprotein and membrane type-1 matrix metalloproteinase. causal interaction,unassigned 2,0 3.4.24.80 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25488667&form=6&db=m Matrix Metalloproteinase-14 Both Sheds Cell Surface Neuronal Glial Antigen 2 (NG2) Proteoglycan on Macrophages and Governs the Response to Peripheral Nerve Injury. ongoing research,therapeutic application,unassigned 3,4,0 3.4.24.80 Phyllodes Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22505012&form=6&db=m Stromal matrix metalloproteinase-14 expression correlates with the grade and biological behavior of mammary phyllodes tumors. causal interaction,unassigned 3,0 3.4.24.80 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10634397&form=6&db=m High levels of matrix metalloproteinases regulate proliferation and hormone secretion in pituitary cells. causal interaction,ongoing research,unassigned 1,4,0 3.4.24.80 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097538&form=6&db=m Expression of MMP14 in invasive pituitary adenomas: relationship to invasion and angiogenesis. causal interaction,unassigned 4,0 3.4.24.80 Placenta Accreta http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29469945&form=6&db=m Extravillous trophoblast invasion in placenta accreta is associated with differential local expression of angiogenic and growth factors: a cross sectional study. unassigned - 3.4.24.80 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26104813&form=6&db=m Peptides do not prevent cleavage of endoglin to produce soluble endoglin. unassigned - 3.4.24.80 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29363569&form=6&db=m LIFR increases the release of soluble endoglin via the upregulation of MMP14 expression in preeclampsia. ongoing research,unassigned 1,0 3.4.24.80 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33389929&form=6&db=m Analyses of soluble endoglin and matrix metalloproteinase 14 using enzyme-linked immunosorbent assay in the diagnosis and assessment of severity of early- and late-onset pre-eclampsia causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0 3.4.24.80 Pregnancy, Ectopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9294857&form=6&db=m Co-ordinated expression of MMP-2 and its putative activator, MT1-MMP, in human placentation. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.24.80 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632347&form=6&db=m Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632347&form=6&db=m Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10822133&form=6&db=m Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11960381&form=6&db=m The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15841326&form=6&db=m Membrane type 1-matrix metalloproteinase promotes human prostate cancer invasion and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15967115&form=6&db=m Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17534446&form=6&db=m Membrane-type 1 matrix metalloproteinase is regulated by sp1 through the differential activation of AKT, JNK, and ERK pathways in human prostate tumor cells. causal interaction,ongoing research,unassigned 4,1,0 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174174&form=6&db=m Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18329693&form=6&db=m Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620173&form=6&db=m Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219645&form=6&db=m LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21849471&form=6&db=m OXIDATIVE STRESS AND PROSTATE CANCER PROGRESSION ARE ELICITED BY MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP). causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.80 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30606769&form=6&db=m Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress. causal interaction,unassigned 4,0 3.4.24.80 protein acetyllysine n-acetyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24136919&form=6&db=m Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence. causal interaction,ongoing research,unassigned 3,2,0 3.4.24.80 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525718&form=6&db=m MMP14 gene polymorphisms in chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.4.24.80 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661247&form=6&db=m Matrix Metalloproteinase (MMP) 14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Pulmonary Emphysema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9759652&form=6&db=m Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema. ongoing research,unassigned 3,0 3.4.24.80 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11555678&form=6&db=m Role of MMP-2 in alveolar epithelial cell repair after bleomycin administration in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.24.80 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11758165&form=6&db=m [mRNA expression of matrix metalloproteinase-2 and membrane type matrix metalloproteinase in pulmonary fibroblasts and macrophages of rat pulmonary fibrosis model] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16829852&form=6&db=m Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.4.24.80 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17467979&form=6&db=m Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.4.24.80 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31466240&form=6&db=m MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues. causal interaction,ongoing research,unassigned 3,4,0 3.4.24.80 Sarcoma, Synovial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29935194&form=6&db=m Matrix metalloproteinase-14 induces epithelial-to-mesenchymal transition in synovial sarcoma. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32838837&form=6&db=m Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0 3.4.24.80 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9610608&form=6&db=m Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.24.80 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805992&form=6&db=m Increased Neuronal Depolarization Evoked by Autoantibodies in Diabetic Obstructive Sleep Apnea: Role for Inflammatory Protease(s) in Generation of Neurotoxic Immunoglobulin Fragment. diagnostic usage,unassigned 3,0 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10504584&form=6&db=m Role of membrane type 1-matrix metalloproteinase and gelatinase A in head and neck squamous cell carcinoma invasion in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10840163&form=6&db=m Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987249&form=6&db=m Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235994&form=6&db=m Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11355270&form=6&db=m MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16470875&form=6&db=m Matrix metalloproteases in head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18642282&form=6&db=m MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22918226&form=6&db=m Potentially Novel Candidate Biomarkers for Head and Neck Squamous Cell Carcinoma Identified Using an Integrated Cell Line-based Discovery Strategy. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28318921&form=6&db=m Influence of TGF-?1 on tumor transition in oral cancer cell and BMSC co-cultures. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31011632&form=6&db=m Discretionary Transduction of MMP-Sensitized Tousled in Head and Neck Cancer. causal interaction,ongoing research,unassigned 4,3,0 3.4.24.80 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31345665&form=6&db=m Influence of tumour necrosis factor alpha on epithelial-mesenchymal transition of oral cancer cells in co-culture with mesenchymal stromal cells. diagnostic usage,ongoing research,unassigned 1,4,0 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448063&form=6&db=m Membrane-type 1 matrix metalloproteinase enhances lymph node metastasis of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21181759&form=6&db=m Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23314917&form=6&db=m Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23394613&form=6&db=m Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14. unassigned - 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24386080&form=6&db=m IGFBP3, a transcriptional target of homeobox D10, is correlated with the prognosis of gastric cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748728&form=6&db=m Increased expression of MMP14 correlates with the poor prognosis of Chinese patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25851348&form=6&db=m Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26576027&form=6&db=m KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26610210&form=6&db=m MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail. causal interaction,unassigned 1,0 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259238&form=6&db=m miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27562173&form=6&db=m Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28827574&form=6&db=m miRNA-584-3p inhibits gastric cancer progression by repressing Yin Yang 1- facilitated MMP-14 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,2 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30532247&form=6&db=m High serum MMP-14 predicts worse survival in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31560170&form=6&db=m High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31619663&form=6&db=m Serum Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) mRNA Protected by Exosomes as a Potential Biomarker for Gastric Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397871&form=6&db=m Overexpression of MMP14 predicts the poor prognosis in gastric cancer: Meta-analysis and database validation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.24.80 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15729288&form=6&db=m Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,4,0 3.4.24.80 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20971083&form=6&db=m Selective MMP-inhibition with Ro 28-2653 in acute experimental stroke - a magnetic resonance imaging efficacy study. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.4.24.80 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19910495&form=6&db=m VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. ongoing research,therapeutic application,unassigned 3,1,0 3.4.24.80 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360607&form=6&db=m Looking at the proteases from a simple perspective. causal interaction,therapeutic application,unassigned 4,1,0 3.4.24.80 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15760917&form=6&db=m Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 3.4.24.80 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927064&form=6&db=m Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.4.24.80 Thyroid Carcinoma, Anaplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32819585&form=6&db=m Membrane type 1 matrix metalloproteinase regulates anaplastic thyroid carcinoma cell growth and invasion into the collagen matrix. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 3.4.24.80 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9545106&form=6&db=m mRNA levels of membrane-type 1 matrix metalloproteinase (MT1-MMP), MMP-2, and MMP-9 and of their inhibitors TIMP-2 and TIMP-3 in normal thyrocytes and thyroid carcinoma cell lines. ongoing research,unassigned 4,0 3.4.24.80 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536854&form=6&db=m Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.4.24.80 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33566639&form=6&db=m Receptor-type protein tyrosine phosphatase alpha (PTP?) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion. ongoing research,unassigned 3,0 3.4.24.80 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26091717&form=6&db=m Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis. causal interaction,ongoing research,unassigned 4,2,0 3.4.24.80 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23136588&form=6&db=m Clinical significance and prognostic value of S100A4 and matrix metalloproteinase-14 in patients with organ-confined bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.4.24.80 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32633349&form=6&db=m High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.24.80 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14533872&form=6&db=m Membrane-associated MMP-2 in human cervical cancer. causal interaction,ongoing research,unassigned 4,4,0 3.4.24.80 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31810492&form=6&db=m DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.4.24.80 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17678629&form=6&db=m Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.24.80 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26850053&form=6&db=m Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury. ongoing research,unassigned 2,0 3.4.24.80 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16171603&form=6&db=m Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.24.80 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26537061&form=6&db=m Interaction between hepatic membrane type 1 matrix metalloproteinase and acireductone dioxygenase 1 regulates hepatitis C virus infection. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.4.24.80 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25759388&form=6&db=m Heterotrimeric G Proteins Directly Regulate MMP14/Membrane Type-1 Matrix Metalloprotease: A Novel Mechanism for GPCR-EGFR Transactivation. unassigned - 3.4.24.80 Wiskott-Aldrich Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21697900&form=6&db=m The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. unassigned -