3.4.22.55	Acrocephalosyndactylia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854168&form=6&db=m	Twist haploinsufficiency in Saethre-Chotzen syndrome induces calvarial osteoblast apoptosis due to increased TNFalpha expression and caspase-2 activation.	causal interaction,unassigned	2,0	
3.4.22.55	Adenocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25010987&form=6&db=m	Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.	causal interaction,ongoing research,unassigned	1,3,0	
3.4.22.55	Adenocarcinoma of Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15941563&form=6&db=m	Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.	ongoing research,therapeutic application,unassigned	4,2,0	
3.4.22.55	Adenocarcinoma of Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18375382&form=6&db=m	c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.	diagnostic usage,ongoing research,unassigned	1,4,0	
3.4.22.55	Adenoma, Pleomorphic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27981346&form=6&db=m	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.	diagnostic usage,ongoing research,unassigned	3,1,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9507158&form=6&db=m	Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.	causal interaction,therapeutic application,unassigned	2,1,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10079193&form=6&db=m	Changes in caspase expression in Alzheimer's disease: comparison with development and aging.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,2,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23748737&form=6&db=m	Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.	causal interaction,therapeutic application,unassigned	4,4,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27901073&form=6&db=m	THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer's Disease.	causal interaction,unassigned	4,0	
3.4.22.55	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31362787&form=6&db=m	A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.	causal interaction,unassigned	3,0	
3.4.22.55	Amyloidosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28389707&form=6&db=m	The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.	therapeutic application,unassigned	2,0	
3.4.22.55	Astrocytoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12761355&form=6&db=m	A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells.	ongoing research,therapeutic application,unassigned	2,2,0	
3.4.22.55	Ataxia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11536012&form=6&db=m	Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.	causal interaction,unassigned	1,0	
3.4.22.55	Ataxia Telangiectasia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24309929&form=6&db=m	Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.	ongoing research,unassigned	1,0	
3.4.22.55	Babesiosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508681&form=6&db=m	Porin Expression Profiles in Haemaphysalis longicornis Infected With Babesia microti.	ongoing research,therapeutic application,unassigned	1,1,0	
3.4.22.55	Bacterial Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526132&form=6&db=m	Old and Novel Functions of Caspase-2.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Brain Injuries	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21674587&form=6&db=m	Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury.	causal interaction,unassigned	3,0	
3.4.22.55	Brain Injuries	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22322383&form=6&db=m	Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic-ischemic brain injury.	causal interaction,unassigned	1,0	
3.4.22.55	Brain Ischemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12067235&form=6&db=m	Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia.	unassigned	-	
3.4.22.55	Brain Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17611651&form=6&db=m	Gene expression profiling of metastatic brain cancer.	causal interaction,diagnostic usage,therapeutic application,unassigned	3,3,1,0	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10832593&form=6&db=m	Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,2,0	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308120&form=6&db=m	The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events.	ongoing research,therapeutic application,unassigned	4,1,0	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19838061&form=6&db=m	Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac).	unassigned	-	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20180631&form=6&db=m	Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,4,0	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23054864&form=6&db=m	Biphasic dose-dependent effect of lithium chloride on survival of human hormone-dependent breast cancer cells (mcf-7).	causal interaction,unassigned	2,0	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23469978&form=6&db=m	Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,3,1	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23672670&form=6&db=m	Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,3,1,0	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24947230&form=6&db=m	The potential role of free chitosan in bone trauma and bone cancer management.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,3,3,1	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25685064&form=6&db=m	The role of individual caspases in cell death induction by taxanes in breast cancer cells.	causal interaction,ongoing research,unassigned	1,3,0	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321954&form=6&db=m	A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.	ongoing research,therapeutic application,unassigned	4,1,0	
3.4.22.55	Breast Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33999360&form=6&db=m	Long non-coding RNA TPT1-AS1 sensitizes breast cancer cell to paclitaxel and inhibits cell proliferation by miR-3156-5p/caspase 2 axis.	ongoing research,therapeutic application,unassigned	1,2,0	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297434&form=6&db=m	[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,4,0	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19279217&form=6&db=m	A tumor suppressor function for caspase-2.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,4	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21724973&form=6&db=m	Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.	causal interaction,unassigned	1,0	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22396545&form=6&db=m	Tumor-suppressing function of caspase-2 requires catalytic site C320 and site S139 in mice.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,4,2	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23645210&form=6&db=m	Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,2,0	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23811850&form=6&db=m	Caspase-2 as a tumour suppressor.	causal interaction,diagnostic usage,therapeutic application,unassigned	2,1,1,0	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25144718&form=6&db=m	An unexpected role for caspase-2 in neuroblastoma.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,2,2,3	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301067&form=6&db=m	Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,2,4	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526085&form=6&db=m	Old, new and emerging functions of caspases.	causal interaction,unassigned	4,0	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27518436&form=6&db=m	Caspase-2 deficiency accelerates chemically induced liver cancer in mice.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27906175&form=6&db=m	Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.	causal interaction,ongoing research,unassigned	4,2,0	
3.4.22.55	Carcinogenesis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33752921&form=6&db=m	Caspase-2 as a master regulator of genomic stability.	ongoing research,unassigned	4,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671409&form=6&db=m	Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis.	causal interaction,therapeutic application,unassigned	4,4,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181909&form=6&db=m	Rescue from enhanced alkylator-induced cell death with low molecular weight sulfur-containing chemoprotectants.	diagnostic usage,ongoing research,unassigned	4,4,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14757846&form=6&db=m	Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells.	ongoing research,therapeutic application,unassigned	4,1,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15511269&form=6&db=m	Loss of caspase-2, -6 and -7 expression in gastric cancers.	causal interaction,diagnostic usage,ongoing research,unassigned	3,3,4,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15827335&form=6&db=m	Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.	causal interaction,therapeutic application,unassigned	1,2,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446371&form=6&db=m	PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells.	ongoing research,unassigned	4,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16652156&form=6&db=m	Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.	ongoing research,therapeutic application,unassigned	2,1,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18064041&form=6&db=m	DNA damage induces two distinct modes of cell death in ovarian carcinomas.	diagnostic usage,ongoing research,unassigned	1,4,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20208132&form=6&db=m	PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,1,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21107704&form=6&db=m	Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines.	causal interaction,ongoing research,therapeutic application,unassigned	1,2,1,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21475302&form=6&db=m	Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1).	ongoing research,unassigned	1,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21940110&form=6&db=m	Somatic mutations of caspase-2 gene in gastric and colorectal cancers.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,1	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22201672&form=6&db=m	TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,3,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23542236&form=6&db=m	The association of taxane resistance genes with the clinical course of ovarian carcinoma.	causal interaction,diagnostic usage,ongoing research,therapeutic application	3,4,2,1	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23568547&form=6&db=m	miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2.	unassigned	-	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25010987&form=6&db=m	Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.	causal interaction,ongoing research,unassigned	1,3,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29719611&form=6&db=m	Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells.	causal interaction,ongoing research,therapeutic application,unassigned	1,4,3,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30025878&form=6&db=m	Caspase-2 is a negative regulator of necroptosis.	diagnostic usage,ongoing research,unassigned	1,4,0	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366165&form=6&db=m	Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,1,2,4	
3.4.22.55	Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31842382&form=6&db=m	Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,2,2,0	
3.4.22.55	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297434&form=6&db=m	[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,4,0	
3.4.22.55	Carcinoma, Hepatocellular	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16012953&form=6&db=m	Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.55	Carcinoma, Mucoepidermoid	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27981346&form=6&db=m	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.	diagnostic usage,ongoing research,unassigned	3,1,0	
3.4.22.55	Carcinoma, Non-Small-Cell Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816202&form=6&db=m	MiR-494 acts as a tumor promoter by targeting CASP2 in non-small cell lung cancer.	diagnostic usage,therapeutic application,unassigned	1,2,0	
3.4.22.55	Carcinoma, Non-Small-Cell Lung	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31897103&form=6&db=m	Upregulated miRNA-182-5p expression in tumor tissue and peripheral blood samples from patients with non-small cell lung cancer is associated with downregulated Caspase 2 expression.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,2,0	
3.4.22.55	Carcinoma, Ovarian Epithelial	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27567588&form=6&db=m	Inhibition of microRNA-383 has tumor suppressive effect in human epithelial ovarian cancer through the action on caspase-2 gene.	ongoing research,therapeutic application,unassigned	2,1,0	
3.4.22.55	Carcinoma, Renal Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20208132&form=6&db=m	PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,1,0	
3.4.22.55	Cardiotoxicity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678744&form=6&db=m	Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors.	causal interaction,therapeutic application,unassigned	1,1,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11536012&form=6&db=m	Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.	causal interaction,unassigned	1,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17188333&form=6&db=m	Caspase-2 deficiency enhances aging-related traits in mice.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21538476&form=6&db=m	Caspase-2 deficiency protects mice from diabetes-induced marrow adiposity.	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22396545&form=6&db=m	Tumor-suppressing function of caspase-2 requires catalytic site C320 and site S139 in mice.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,4,2	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22498700&form=6&db=m	Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.	causal interaction,unassigned	4,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24248351&form=6&db=m	Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,4,1	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25053716&form=6&db=m	Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,1,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25531319&form=6&db=m	Caspase-2 protects against oxidative stress in vivo.	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26890135&form=6&db=m	Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.	causal interaction,unassigned	4,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27518436&form=6&db=m	Caspase-2 deficiency accelerates chemically induced liver cancer in mice.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27906175&form=6&db=m	Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.	causal interaction,ongoing research,unassigned	4,2,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29072701&form=6&db=m	Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.	causal interaction,unassigned	2,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30670683&form=6&db=m	Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
3.4.22.55	caspase-2 deficiency	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31399584&form=6&db=m	Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3? signaling.	causal interaction,diagnostic usage,unassigned	1,1,0	
3.4.22.55	Cholangiocarcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21464824&form=6&db=m	Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,1,0	
3.4.22.55	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970065&form=6&db=m	Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis.	ongoing research,unassigned	1,0	
3.4.22.55	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16617056&form=6&db=m	Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol.	ongoing research,therapeutic application,unassigned	3,2,0	
3.4.22.55	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21667160&form=6&db=m	Simulated colon fiber metabolome regulates genes involved in cell cycle, apoptosis, and energy metabolism in human colon cancer cells.	causal interaction,ongoing research,therapeutic application,unassigned	1,1,2,0	
3.4.22.55	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26962687&form=6&db=m	MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,2,3,2	
3.4.22.55	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29245990&form=6&db=m	Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and ?-H2AX in colon cancer cells.	therapeutic application,unassigned	1,0	
3.4.22.55	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30976094&form=6&db=m	Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.	ongoing research,therapeutic application,unassigned	3,4,0	
3.4.22.55	Colonic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31646793&form=6&db=m	Zingiberene inhibits in vitro and in vivo human colon cancer cell growth via autophagy induction, suppression of PI3K/AKT/mTOR Pathway and caspase 2 deactivation.	ongoing research,unassigned	3,0	
3.4.22.55	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166278&form=6&db=m	T25 repeat in the 3' untranslated region of the CASP2 gene: a sensitive and specific marker for microsatellite instability in colorectal cancer.	diagnostic usage,unassigned	1,0	
3.4.22.55	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19154411&form=6&db=m	Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential.	causal interaction,ongoing research,therapeutic application,unassigned	1,2,1,0	
3.4.22.55	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21940110&form=6&db=m	Somatic mutations of caspase-2 gene in gastric and colorectal cancers.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,1	
3.4.22.55	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28073006&form=6&db=m	BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.	unassigned	-	
3.4.22.55	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28219770&form=6&db=m	Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2.	ongoing research,unassigned	3,0	
3.4.22.55	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366165&form=6&db=m	Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,1,2,4	
3.4.22.55	Colorectal Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32065080&form=6&db=m	CAT25 defines microsatellite instability in colorectal cancer by high-resolution melting PCR.	diagnostic usage,unassigned	1,0	
3.4.22.55	Dementia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27901073&form=6&db=m	THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer's Disease.	causal interaction,unassigned	4,0	
3.4.22.55	Dementia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31362787&form=6&db=m	A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.	causal interaction,unassigned	3,0	
3.4.22.55	Dementia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32123248&form=6&db=m	A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals.	diagnostic usage,ongoing research,unassigned	1,1,0	
3.4.22.55	Down Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32046398&form=6&db=m	Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface.	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,2,0	
3.4.22.55	Dysgeusia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10931486&form=6&db=m	Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells.	causal interaction,unassigned	1,0	
3.4.22.55	Epilepsy	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17627033&form=6&db=m	Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.	ongoing research,unassigned	4,0	
3.4.22.55	Epilepsy, Temporal Lobe	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17627033&form=6&db=m	Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.	ongoing research,unassigned	4,0	
3.4.22.55	Fatty Liver	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25053716&form=6&db=m	Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,1,0	
3.4.22.55	Fatty Liver	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30220454&form=6&db=m	ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Fatty Liver	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34052187&form=6&db=m	Upregulation of miR-96-5p by bone marrow mesenchymal stem cells and their exosomes alleviate non-alcoholic steatohepatitis: Emphasis on caspase-2 signaling inhibition.	ongoing research,unassigned	2,0	
3.4.22.55	Fibrosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22595758&form=6&db=m	PIDDosome-independent tumor suppression by Caspase-2.	causal interaction,unassigned	1,0	
3.4.22.55	Frontotemporal Dementia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31362787&form=6&db=m	A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.	causal interaction,unassigned	3,0	
3.4.22.55	Glaucoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23285297&form=6&db=m	Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Glaucoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054518&form=6&db=m	Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection.	unassigned	-	
3.4.22.55	Glioblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25330190&form=6&db=m	Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain.	causal interaction,ongoing research,unassigned	3,2,0	
3.4.22.55	Glioma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27049919&form=6&db=m	microRNA-149 targets caspase-2 in glioma progression.	causal interaction,ongoing research,therapeutic application,unassigned	2,1,1,0	
3.4.22.55	Glucose Intolerance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526132&form=6&db=m	Old and Novel Functions of Caspase-2.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Heart Failure	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14732211&form=6&db=m	Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.55	Hematologic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23645210&form=6&db=m	Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,2,0	
3.4.22.55	Hepatitis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28389707&form=6&db=m	The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.	therapeutic application,unassigned	2,0	
3.4.22.55	Hepatitis C	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297434&form=6&db=m	[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,4,0	
3.4.22.55	Huntington Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17902043&form=6&db=m	Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range.	causal interaction,unassigned	4,0	
3.4.22.55	Huntington Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21854568&form=6&db=m	Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington Disease.	ongoing research,unassigned	2,0	
3.4.22.55	Huntington Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31358058&form=6&db=m	A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients.	unassigned	-	
3.4.22.55	Immune System Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33316578&form=6&db=m	Transcriptome reveals the important role of metabolic imbalances, immune disorders and apoptosis in the treatment of Procambarus clarkii at super high temperature.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9427555&form=6&db=m	Cloning and expression of the cDNA encoding rat caspase-2.	ongoing research,unassigned	1,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11073159&form=6&db=m	Reactivation of Nedd-2, a developmentally down-regulated apoptotic gene, in apoptosis induced by a street strain of rabies virus.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,2,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11099484&form=6&db=m	HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism.	diagnostic usage,unassigned	3,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297434&form=6&db=m	[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,4,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12692289&form=6&db=m	Caspase-mediated cleavage of the feline calicivirus capsid protein.	ongoing research,therapeutic application,unassigned	2,1,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15033797&form=6&db=m	Apoptosis in cultured cells infected with feline calicivirus.	therapeutic application,unassigned	1,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15163747&form=6&db=m	Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation.	therapeutic application,unassigned	1,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18519556&form=6&db=m	Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin.	diagnostic usage,unassigned	3,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19714247&form=6&db=m	Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus.	unassigned	-	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25942495&form=6&db=m	Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26296773&form=6&db=m	Intrinsic apoptosis and proinflammatory cytokines regulated in human astrocytes infected with enterovirus 71.	therapeutic application,unassigned	1,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526132&form=6&db=m	Old and Novel Functions of Caspase-2.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33481814&form=6&db=m	Intrinsic apoptosis and cytokine induction regulated in human tonsillar epithelial cells infected with enterovirus A71.	ongoing research,unassigned	4,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145058&form=6&db=m	The IRE1? Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function.	ongoing research,therapeutic application,unassigned	3,1,0	
3.4.22.55	Infections	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34358576&form=6&db=m	miR-2 contributes to WSSV infection by targeting Caspase 2 in mud crab (Scylla paramamosain).	causal interaction,unassigned	1,0	
3.4.22.55	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21455726&form=6&db=m	Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.55	Insulin Resistance	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27551503&form=6&db=m	Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice.	ongoing research,therapeutic application,unassigned	1,1,0	
3.4.22.55	Intellectual Disability	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33414379&form=6&db=m	Biallelic mutations in the death domain of PIDD1 impair caspase-2 activation and are associated with intellectual disability.	causal interaction,unassigned	3,0	
3.4.22.55	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15827335&form=6&db=m	Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.	causal interaction,therapeutic application,unassigned	1,2,0	
3.4.22.55	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15917662&form=6&db=m	Association of caspase-2 with the promyelocytic leukemia protein nuclear bodies.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.55	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16545898&form=6&db=m	Apoptosis-inducing active components from Corbicula fluminea through activation of caspase-2 and production of reactive oxygen species in human leukemia HL-60 cells.	ongoing research,unassigned	3,0	
3.4.22.55	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19838061&form=6&db=m	Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac).	unassigned	-	
3.4.22.55	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21332795&form=6&db=m	Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers.	causal interaction,unassigned	4,0	
3.4.22.55	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22555976&form=6&db=m	Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt.	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,3,0	
3.4.22.55	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24044460&form=6&db=m	BMP4 is Involved in the Chemoresistance of Myeloid Leukemia Cells Through Regulating Autophagy-Apoptosis Balance.	causal interaction,unassigned	1,0	
3.4.22.55	Leukemia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25942495&form=6&db=m	Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.55	Leukemia, Lymphoid	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766499&form=6&db=m	Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells.	therapeutic application,unassigned	1,0	
3.4.22.55	Leukemia, Myeloid, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9787143&form=6&db=m	Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia.	causal interaction,diagnostic usage,unassigned	1,4,0	
3.4.22.55	Leukemia, Myeloid, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632337&form=6&db=m	Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,3,2	
3.4.22.55	Leukemia, Myeloid, Acute	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11426520&form=6&db=m	The clinical significance of caspase regulation in acute leukemia.	causal interaction,diagnostic usage,unassigned	3,1,0	
3.4.22.55	Leukemia, T-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31060401&form=6&db=m	Induction of caspase-2 gene expression in carboxyl-functionalized carbon nanotube-treated human T-cell leukemia (Jurkat) cell line.	ongoing research,unassigned	4,0	
3.4.22.55	Lewy Body Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31362787&form=6&db=m	A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease.	causal interaction,unassigned	3,0	
3.4.22.55	Lichen Planus, Oral	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24931220&form=6&db=m	Metallothionein, a marker of antiapoptosis, is associated with clinical forms of oral lichen planus.	causal interaction,diagnostic usage,ongoing research,unassigned	1,3,3,0	
3.4.22.55	Liver Cirrhosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25053716&form=6&db=m	Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,1,0	
3.4.22.55	Liver Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26890135&form=6&db=m	Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.	causal interaction,unassigned	4,0	
3.4.22.55	Liver Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526132&form=6&db=m	Old and Novel Functions of Caspase-2.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Liver Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30220454&form=6&db=m	ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Liver Diseases, Alcoholic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19332555&form=6&db=m	Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.55	Liver Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27518436&form=6&db=m	Caspase-2 deficiency accelerates chemically induced liver cancer in mice.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.55	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301067&form=6&db=m	Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,2,4	
3.4.22.55	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30408460&form=6&db=m	A synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), triggers reactive oxygen species-induced apoptosis independently of p53 in A549 lung cancer cells.	causal interaction,therapeutic application,unassigned	3,2,0	
3.4.22.55	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816202&form=6&db=m	MiR-494 acts as a tumor promoter by targeting CASP2 in non-small cell lung cancer.	diagnostic usage,therapeutic application,unassigned	1,2,0	
3.4.22.55	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31897103&form=6&db=m	Upregulated miRNA-182-5p expression in tumor tissue and peripheral blood samples from patients with non-small cell lung cancer is associated with downregulated Caspase 2 expression.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,2,0	
3.4.22.55	Lung Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33279671&form=6&db=m	Lung cancer cells and their sensitivity/resistance to cisplatin chemotherapy: Role of microRNAs and upstream mediators.	therapeutic application,unassigned	2,0	
3.4.22.55	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711674&form=6&db=m	CpG oligodeoxynucleotide 5mer-induced apoptosis in MOLT-4 leukaemia cells does not require caspase 3 or new protein synthesis.	unassigned	-	
3.4.22.55	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19279217&form=6&db=m	A tumor suppressor function for caspase-2.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,4	
3.4.22.55	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20861880&form=6&db=m	The engine driving the ship: metabolic steering of cell proliferation and death.	unassigned	-	
3.4.22.55	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22498700&form=6&db=m	Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.	causal interaction,unassigned	4,0	
3.4.22.55	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22595758&form=6&db=m	PIDDosome-independent tumor suppression by Caspase-2.	causal interaction,unassigned	1,0	
3.4.22.55	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25144718&form=6&db=m	An unexpected role for caspase-2 in neuroblastoma.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,2,2,3	
3.4.22.55	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25857265&form=6&db=m	The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.	causal interaction,ongoing research,unassigned	1,1,0	
3.4.22.55	Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30670683&form=6&db=m	Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
3.4.22.55	Lymphoma, B-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20861880&form=6&db=m	The engine driving the ship: metabolic steering of cell proliferation and death.	unassigned	-	
3.4.22.55	Lymphoma, B-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24661060&form=6&db=m	Induced cell death pathway post photodynamic therapy using a metallophthalocyanine photosensitizer in breast cancer cells.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.55	Lymphoma, B-Cell	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508681&form=6&db=m	Porin Expression Profiles in Haemaphysalis longicornis Infected With Babesia microti.	ongoing research,therapeutic application,unassigned	1,1,0	
3.4.22.55	Lymphoma, B-Cell, Marginal Zone	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711674&form=6&db=m	CpG oligodeoxynucleotide 5mer-induced apoptosis in MOLT-4 leukaemia cells does not require caspase 3 or new protein synthesis.	unassigned	-	
3.4.22.55	Lymphopenia	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051319&form=6&db=m	Mapping of caspase-2 in the rat and its exclusion as a candidate gene for lymphopenia.	causal interaction,diagnostic usage,ongoing research,unassigned	1,1,2,0	
3.4.22.55	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16569656&form=6&db=m	H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells.	ongoing research,therapeutic application,unassigned	1,4,0	
3.4.22.55	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308071&form=6&db=m	Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2.	causal interaction,unassigned	4,0	
3.4.22.55	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20187765&form=6&db=m	Increased Caspase-2 Activity is Associated With Induction of Apoptosis in IFN-beta Sensitive Melanoma Cell Lines.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.55	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21809047&form=6&db=m	Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,1,0	
3.4.22.55	Melanoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263976&form=6&db=m	NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.	causal interaction,ongoing research,therapeutic application,unassigned	1,2,1,0	
3.4.22.55	Memory Disorders	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27723722&form=6&db=m	Caspase-2 cleavage of tau reversibly impairs memory.	ongoing research,unassigned	2,0	
3.4.22.55	Memory Disorders	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31399584&form=6&db=m	Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3? signaling.	causal interaction,diagnostic usage,unassigned	1,1,0	
3.4.22.55	Metabolic Syndrome	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26890135&form=6&db=m	Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.	causal interaction,unassigned	4,0	
3.4.22.55	Mouth Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22432688&form=6&db=m	Soy protein extract (SPE) exhibits differential in vitro cell proliferation effects in oral cancer and normal cell lines.	causal interaction,unassigned	4,0	
3.4.22.55	Multiple Myeloma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18723477&form=6&db=m	Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells.	causal interaction,therapeutic application,unassigned	4,2,0	
3.4.22.55	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17101764&form=6&db=m	Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues.	diagnostic usage,ongoing research,therapeutic application,unassigned	4,2,1,0	
3.4.22.55	Neoplasm Metastasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18708361&form=6&db=m	c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.	unassigned	-	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9377572&form=6&db=m	High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,3,2	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9414421&form=6&db=m	Establishment of human prostate tumor xenografts in nude mice and response to 9-nitrocamptothecin in vivo and in vitro does not correlate with the expression of various apoptosis-regulating proteins.	causal interaction,ongoing research,unassigned	1,3,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671409&form=6&db=m	Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis.	causal interaction,therapeutic application,unassigned	4,4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10713730&form=6&db=m	Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD.	therapeutic application,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964483&form=6&db=m	Tumor necrosis factor-alpha-induced apoptosis in olfactory epithelium in vitro: possible roles of caspase 1 (ICE), caspase 2 (ICH-1), and caspase 3 (CPP32).	unassigned	-	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11331417&form=6&db=m	Caspase-2 activation is redundant during seizure-induced neuronal death.	ongoing research,therapeutic application,unassigned	3,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408858&form=6&db=m	Support for an infection-induced apoptotic pathway in human fetal membranes.	ongoing research,unassigned	3,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12543810&form=6&db=m	Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12920126&form=6&db=m	Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.	causal interaction,therapeutic application,unassigned	1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14646520&form=6&db=m	Caspase-2/NEDD-2 protease mediates execution of apoptosis in AK-5 tumor cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,3,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210730&form=6&db=m	Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die.	causal interaction,diagnostic usage,unassigned	1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492260&form=6&db=m	Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15640352&form=6&db=m	The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.	causal interaction,unassigned	3,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15737569&form=6&db=m	Imbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology.	causal interaction,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15865046&form=6&db=m	In situ analysis of Raidd-beta-galactosidase fusion gene expression in transgenic mouse midgestation embryos.	therapeutic application,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867794&form=6&db=m	Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,1,4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16012953&form=6&db=m	Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16172118&form=6&db=m	Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis.	ongoing research,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16193064&form=6&db=m	Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.	diagnostic usage,ongoing research,therapeutic application,unassigned	1,1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16297799&form=6&db=m	Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion.	therapeutic application,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16397230&form=6&db=m	Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer.	ongoing research,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16596221&form=6&db=m	Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment.	therapeutic application,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16843822&form=6&db=m	Beta-carotene: a colorful killer of cancer cells? A commentary on "ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis".	unassigned	-	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17101764&form=6&db=m	Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues.	diagnostic usage,ongoing research,therapeutic application,unassigned	4,2,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17195089&form=6&db=m	Histone deacetylase inhibitors enhance Ad5-TRAIL killing of TRAIL-resistant prostate tumor cells through increased caspase-2 activity.	causal interaction,therapeutic application,unassigned	3,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18043285&form=6&db=m	Molecular differentiation of early and late stage laryngeal squamous cell carcinoma: an exploratory analysis.	causal interaction,therapeutic application,unassigned	1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18067132&form=6&db=m	Natural agents targeting the alpha7-nicotinic-receptor in NSCLC: a promising prospective in anti-cancer drug development.	ongoing research,unassigned	3,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18375382&form=6&db=m	c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.	diagnostic usage,ongoing research,unassigned	1,4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18425362&form=6&db=m	Secretory leukoprotease inhibitor inhibits cell growth through apoptotic pathway on ovarian cancer.	therapeutic application,unassigned	2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18510930&form=6&db=m	Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.	causal interaction,therapeutic application,unassigned	2,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18840686&form=6&db=m	Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5.	causal interaction,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19279217&form=6&db=m	A tumor suppressor function for caspase-2.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,4	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19386248&form=6&db=m	Genotoxic, cytostatic, antineoplastic and apoptotic effects of newly synthesized antitumour steroidal esters.	causal interaction,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19479377&form=6&db=m	Caspase-2: controversial killer or checkpoint controller?	causal interaction,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19890334&form=6&db=m	Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19935698&form=6&db=m	Caspase 2-mediated tumor suppression involves survivin gene silencing.	causal interaction,ongoing research,therapeutic application,unassigned	3,2,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20158568&form=6&db=m	The role of caspase-2 in stress-induced apoptosis.	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20180631&form=6&db=m	Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20208132&form=6&db=m	PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20623183&form=6&db=m	Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G(2)/M checkpoint signaling.	causal interaction,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20888918&form=6&db=m	Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains.	ongoing research,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20957081&form=6&db=m	Altered Expression of Signaling Genes in Jurkat Cells upon FTY720 Induced Apoptosis.	diagnostic usage,unassigned	3,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21051981&form=6&db=m	Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy.	diagnostic usage,ongoing research,therapeutic application,unassigned	3,3,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21332795&form=6&db=m	Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers.	causal interaction,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21464824&form=6&db=m	Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.	causal interaction,ongoing research,therapeutic application,unassigned	1,3,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21828056&form=6&db=m	Structural and enzymatic insights into caspase-2 substrate recognition and catalysis.	causal interaction,unassigned	2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21903589&form=6&db=m	Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.	causal interaction,ongoing research,therapeutic application,unassigned	3,4,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21940110&form=6&db=m	Somatic mutations of caspase-2 gene in gastric and colorectal cancers.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,1	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002103&form=6&db=m	5-Phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells.	causal interaction,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22014571&form=6&db=m	Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.	unassigned	-	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22075987&form=6&db=m	Caspase-2: the orphan caspase.	causal interaction,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22077397&form=6&db=m	Induction of caspase-2 activation by a DNA enzyme evokes tumor cell apoptosis.	causal interaction,ongoing research,unassigned	1,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22201672&form=6&db=m	TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,3,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22343713&form=6&db=m	Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22396545&form=6&db=m	Tumor-suppressing function of caspase-2 requires catalytic site C320 and site S139 in mice.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,4,2	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22498700&form=6&db=m	Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.	causal interaction,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22595758&form=6&db=m	PIDDosome-independent tumor suppression by Caspase-2.	causal interaction,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23404198&form=6&db=m	TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23454491&form=6&db=m	Apoptosis is signalled early by low doses of ionising radiation in a radiation-induced bystander effect.	therapeutic application,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23469978&form=6&db=m	Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,3,1	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23645210&form=6&db=m	Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23808152&form=6&db=m	[Caspase-2: what do we know today?].	causal interaction,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23811850&form=6&db=m	Caspase-2 as a tumour suppressor.	causal interaction,diagnostic usage,therapeutic application,unassigned	2,1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24248351&form=6&db=m	Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,1,4,1	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24567095&form=6&db=m	Caspase-2 protocols.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24879153&form=6&db=m	A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24882576&form=6&db=m	Caspase-2: the reinvented enzyme.	causal interaction,ongoing research,therapeutic application,unassigned	1,1,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25114039&form=6&db=m	Caspase-2 regulates oncogene-induced senescence.	therapeutic application,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25144718&form=6&db=m	An unexpected role for caspase-2 in neuroblastoma.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,2,2,3	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301067&form=6&db=m	Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,2,4	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526085&form=6&db=m	Old, new and emerging functions of caspases.	causal interaction,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25531319&form=6&db=m	Caspase-2 protects against oxidative stress in vivo.	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25857265&form=6&db=m	The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.	causal interaction,ongoing research,unassigned	1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25942495&form=6&db=m	Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells.	causal interaction,therapeutic application,unassigned	3,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26000607&form=6&db=m	The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells.	causal interaction,therapeutic application,unassigned	3,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26962687&form=6&db=m	MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,2,3,2	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27017918&form=6&db=m	Cardiac glycoside-induced cell death and Rho/Rho kinase pathway: Implication of different regulation in cancer cell lines.	therapeutic application,unassigned	2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27049919&form=6&db=m	microRNA-149 targets caspase-2 in glioma progression.	causal interaction,ongoing research,therapeutic application,unassigned	2,1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27567588&form=6&db=m	Inhibition of microRNA-383 has tumor suppressive effect in human epithelial ovarian cancer through the action on caspase-2 gene.	ongoing research,therapeutic application,unassigned	2,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622714&form=6&db=m	Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer.	therapeutic application,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27906175&form=6&db=m	Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.	causal interaction,ongoing research,unassigned	4,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27981346&form=6&db=m	Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.	diagnostic usage,ongoing research,unassigned	3,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27991927&form=6&db=m	Caspase-2-mediated cell death is required for deleting aneuploid cells.	unassigned	-	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28130254&form=6&db=m	BCL9L Dysfunction Promotes Aneuploidy Tolerance in Colon Tumors.	causal interaction,ongoing research,unassigned	1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197379&form=6&db=m	Caspase-2 and oxidative stress underlie the immunogenic potential of high hydrostatic pressure-induced cancer cell death.	causal interaction,unassigned	2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28315432&form=6&db=m	Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer.	causal interaction,therapeutic application,unassigned	2,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526132&form=6&db=m	Old and Novel Functions of Caspase-2.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29016221&form=6&db=m	Apoptotic and Immunosuppressive Effects of Turmeric Paste on 7, 12 Di Methyl Benz (a) Anthracene Induced Skin Tumor Model of Wistar Rat.	causal interaction,therapeutic application,unassigned	1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29104628&form=6&db=m	Renal sympathetic denervation improves myocardial apoptosis in rats with isoproterenol-induced heart failure by downregulation of tumor necrosis factor-? and nuclear factor-?B.	diagnostic usage,unassigned	4,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29362422&form=6&db=m	A caspase-2-RFXANK interaction and its implication for MHC class II expression.	causal interaction,therapeutic application,unassigned	1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29875129&form=6&db=m	Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators.	diagnostic usage,therapeutic application,unassigned	1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30122943&form=6&db=m	Melittin induces NSCLC apoptosis via inhibition of miR-183.	ongoing research,unassigned	2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30363050&form=6&db=m	[Caspase-2 as an Oncosupressor and Metabolism Regulator: What Life Will Bring over the Long Run?]	causal interaction,ongoing research,unassigned	1,3,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30670683&form=6&db=m	Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816202&form=6&db=m	MiR-494 acts as a tumor promoter by targeting CASP2 in non-small cell lung cancer.	diagnostic usage,therapeutic application,unassigned	1,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31028961&form=6&db=m	Triple-threat activity of PEDF in bone tumors: Tumor inhibition, tissue preservation and cardioprotection against doxorubicin.	unassigned	-	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31318608&form=6&db=m	Down-regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR-432-5p/?-catenin feedback loop.	causal interaction,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31897103&form=6&db=m	Upregulated miRNA-182-5p expression in tumor tissue and peripheral blood samples from patients with non-small cell lung cancer is associated with downregulated Caspase 2 expression.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,2,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32438737&form=6&db=m	The Role of Caspase-2 in Regulating Cell Fate.	causal interaction,unassigned	3,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32921524&form=6&db=m	Caspase 2 and p53 Reunited in Tumor Control.	diagnostic usage,therapeutic application,unassigned	1,1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33425918&form=6&db=m	Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,3,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34417692&form=6&db=m	Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell.	causal interaction,unassigned	1,0	
3.4.22.55	Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34495750&form=6&db=m	Prefrontal Cortex and Hippocampus Inflammation in Mice Fed High-Carbohydrate or High-Fat Diets.	ongoing research,therapeutic application,unassigned	3,1,0	
3.4.22.55	Neoplasms, Germ Cell and Embryonal	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12543810&form=6&db=m	Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.	causal interaction,ongoing research,therapeutic application,unassigned	4,4,4,0	
3.4.22.55	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11146107&form=6&db=m	Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.	causal interaction,unassigned	3,0	
3.4.22.55	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992472&form=6&db=m	Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis.	causal interaction,ongoing research,unassigned	1,2,0	
3.4.22.55	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15812315&form=6&db=m	Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress.	ongoing research,unassigned	2,0	
3.4.22.55	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15825194&form=6&db=m	Caspases-2, -3, and -7 are involved in thapsigargin-induced apoptosis of SH-SY5Y neuroblastoma cells.	ongoing research,unassigned	2,0	
3.4.22.55	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21859926&form=6&db=m	Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe.	ongoing research,therapeutic application,unassigned	2,1,0	
3.4.22.55	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25144718&form=6&db=m	An unexpected role for caspase-2 in neuroblastoma.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,2,2,3	
3.4.22.55	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526132&form=6&db=m	Old and Novel Functions of Caspase-2.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Neuroblastoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30670683&form=6&db=m	Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.	causal interaction,ongoing research,therapeutic application,unassigned	4,1,1,0	
3.4.22.55	Neurodegenerative Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28885866&form=6&db=m	Caspase inhibitors: a review of recently patented compounds (2013-2015).	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Non-alcoholic Fatty Liver Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21455726&form=6&db=m	Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.55	Non-alcoholic Fatty Liver Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26403427&form=6&db=m	Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.	causal interaction,unassigned	3,0	
3.4.22.55	Non-alcoholic Fatty Liver Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26890135&form=6&db=m	Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.	causal interaction,unassigned	4,0	
3.4.22.55	Obesity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26890135&form=6&db=m	Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.	causal interaction,unassigned	4,0	
3.4.22.55	Obesity	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29072701&form=6&db=m	Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.	causal interaction,unassigned	2,0	
3.4.22.55	Optic Nerve Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054518&form=6&db=m	Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection.	unassigned	-	
3.4.22.55	Optic Nerve Injuries	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21677688&form=6&db=m	Ocular neuroprotection by siRNA targeting caspase-2.	causal interaction,therapeutic application,unassigned	1,3,0	
3.4.22.55	Optic Nerve Injuries	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526132&form=6&db=m	Old and Novel Functions of Caspase-2.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Optic Nerve Injuries	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413361&form=6&db=m	Effects of intravitreal injection of siRNA against caspase-2 on retinal and optic nerve degeneration in air blast induced ocular trauma.	ongoing research,unassigned	4,0	
3.4.22.55	Optic Neuritis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23285297&form=6&db=m	Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats.	causal interaction,therapeutic application,unassigned	3,4,0	
3.4.22.55	Optic Neuropathy, Ischemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054518&form=6&db=m	Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection.	unassigned	-	
3.4.22.55	Optic Neuropathy, Ischemic	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33296631&form=6&db=m	[Caspase inhibition: From cellular biology and thanatology to potential clinical agents].	therapeutic application,unassigned	4,0	
3.4.22.55	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18375382&form=6&db=m	c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.	diagnostic usage,ongoing research,unassigned	1,4,0	
3.4.22.55	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18708361&form=6&db=m	c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.	unassigned	-	
3.4.22.55	Osteosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20180631&form=6&db=m	Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,4,0	
3.4.22.55	Ovarian Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25151963&form=6&db=m	Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.	causal interaction,therapeutic application,unassigned	4,4,0	
3.4.22.55	Ovarian Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27193717&form=6&db=m	Mechanism of caspase-2 activation upon DNA damage.	ongoing research,therapeutic application,unassigned	4,2,0	
3.4.22.55	Pancreatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28389707&form=6&db=m	The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.	therapeutic application,unassigned	2,0	
3.4.22.55	Pancreatitis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19850968&form=6&db=m	Inflammatory cells regulate p53 and caspases in acute pancreatitis.	therapeutic application,unassigned	1,0	
3.4.22.55	Papilloma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16777994&form=6&db=m	Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.	causal interaction,unassigned	1,0	
3.4.22.55	Polycystic Kidney, Autosomal Dominant	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15698430&form=6&db=m	Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD).	unassigned	-	
3.4.22.55	Precursor Cell Lymphoblastic Leukemia-Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632337&form=6&db=m	Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,4,3,2	
3.4.22.55	Precursor Cell Lymphoblastic Leukemia-Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11426520&form=6&db=m	The clinical significance of caspase regulation in acute leukemia.	causal interaction,diagnostic usage,unassigned	3,1,0	
3.4.22.55	Precursor Cell Lymphoblastic Leukemia-Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15917298&form=6&db=m	Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.	diagnostic usage,unassigned	3,0	
3.4.22.55	Precursor Cell Lymphoblastic Leukemia-Lymphoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740775&form=6&db=m	Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.	causal interaction,therapeutic application,unassigned	4,1,0	
3.4.22.55	Primary Immunodeficiency Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30245858&form=6&db=m	PIDD-dependent activation of caspase-2-mediated mitochondrial injury in E1A-induced cellular sensitivity to macrophage nitric oxide-induced apoptosis.	causal interaction,therapeutic application,unassigned	1,1,0	
3.4.22.55	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849572&form=6&db=m	Chronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivo.	causal interaction,diagnostic usage,ongoing research,unassigned	1,1,4,0	
3.4.22.55	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17110788&form=6&db=m	TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome.	diagnostic usage,unassigned	3,0	
3.4.22.55	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17262078&form=6&db=m	Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells.	causal interaction,unassigned	4,0	
3.4.22.55	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18615564&form=6&db=m	Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells.	causal interaction,therapeutic application,unassigned	2,1,0	
3.4.22.55	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20180631&form=6&db=m	Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.	causal interaction,diagnostic usage,ongoing research,unassigned	3,1,4,0	
3.4.22.55	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20655966&form=6&db=m	Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells.	causal interaction,therapeutic application,unassigned	2,1,0	
3.4.22.55	Prostatic Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207900&form=6&db=m	Caspase-2-Based Regulation of the Androgen Receptor and Cell Cycle in the Prostate Cancer Cell Line LNCaP.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,4	
3.4.22.55	Rabies	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11073159&form=6&db=m	Reactivation of Nedd-2, a developmentally down-regulated apoptotic gene, in apoptosis induced by a street strain of rabies virus.	causal interaction,ongoing research,therapeutic application,unassigned	3,1,2,0	
3.4.22.55	Rabies	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28129024&form=6&db=m	BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein.	causal interaction,therapeutic application,unassigned	1,1,0	
3.4.22.55	Reperfusion Injury	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867794&form=6&db=m	Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.	causal interaction,diagnostic usage,therapeutic application,unassigned	1,1,4,0	
3.4.22.55	Retinal Degeneration	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21768104&form=6&db=m	A sponge transgenic mouse model reveals important roles for the miRNA-183/96/182 cluster in post-mitotic photoreceptors of the retina.	ongoing research,unassigned	3,0	
3.4.22.55	Rhabdomyosarcoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16475717&form=6&db=m	TRAIL-induced cytotoxicity in a melphalan-resistant rhabdomyosarcoma cell line via activation of caspase-2.	ongoing research,unassigned	2,0	
3.4.22.55	Seizures	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11331417&form=6&db=m	Caspase-2 activation is redundant during seizure-induced neuronal death.	ongoing research,therapeutic application,unassigned	3,2,0	
3.4.22.55	Small Cell Lung Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181909&form=6&db=m	Rescue from enhanced alkylator-induced cell death with low molecular weight sulfur-containing chemoprotectants.	diagnostic usage,ongoing research,unassigned	4,4,0	
3.4.22.55	Small Cell Lung Carcinoma	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22201672&form=6&db=m	TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death.	causal interaction,ongoing research,therapeutic application,unassigned	4,3,3,0	
3.4.22.55	Stomach Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15511269&form=6&db=m	Loss of caspase-2, -6 and -7 expression in gastric cancers.	causal interaction,diagnostic usage,ongoing research,unassigned	3,3,4,0	
3.4.22.55	Stomach Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21940110&form=6&db=m	Somatic mutations of caspase-2 gene in gastric and colorectal cancers.	causal interaction,diagnostic usage,ongoing research,therapeutic application	4,3,4,1	
3.4.22.55	Stomach Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31611962&form=6&db=m	Prognostic significance of mRNA expression of CASPs in gastric cancer.	diagnostic usage,unassigned	4,0	
3.4.22.55	Stroke	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30779911&form=6&db=m	miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke.	therapeutic application,unassigned	2,0	
3.4.22.55	Tauopathies	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27723722&form=6&db=m	Caspase-2 cleavage of tau reversibly impairs memory.	ongoing research,unassigned	2,0	
3.4.22.55	Telangiectasis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18510930&form=6&db=m	Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.	causal interaction,therapeutic application,unassigned	2,1,0	
3.4.22.55	Thyroid Cancer, Papillary	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22486813&form=6&db=m	Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.	diagnostic usage,unassigned	3,0	
3.4.22.55	Thyroid Neoplasms	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28730778&form=6&db=m	Study on the effect of integrin ???6 on the proliferation and apoptosis of thyroid carcinoma cells.	causal interaction,unassigned	1,0	
3.4.22.55	Tuberculosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18280621&form=6&db=m	Immunogenicity and protective efficacy of a tuberculosis DNA vaccine co-expressing pro-apoptotic caspase-3.	therapeutic application,unassigned	2,0	
3.4.22.55	Virus Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297434&form=6&db=m	[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]	causal interaction,diagnostic usage,ongoing research,unassigned	4,4,4,0	
3.4.22.55	Virus Diseases	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34358576&form=6&db=m	miR-2 contributes to WSSV infection by targeting Caspase 2 in mud crab (Scylla paramamosain).	causal interaction,unassigned	1,0