3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9296555&form=6&db=m Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. causal interaction,ongoing research,unassigned 3,1,0 3.4.22.53 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22629380&form=6&db=m Human U87 astrocytoma cell invasion induced by interaction of ?ig-h3 with integrin ?5?1 involves calpain-2. causal interaction,unassigned 3,0 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335024&form=6&db=m Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,3 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435971&form=6&db=m Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228653&form=6&db=m Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448882&form=6&db=m Calpain system protein expression and activity in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21950698&form=6&db=m Involvement of calpain 2 in ionomycin-induced cell death in cultured mouse lens epithelial cells. causal interaction,unassigned 4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25052996&form=6&db=m Loss of calpastatin leads to activation of calpain in human lens epithelial cells. causal interaction,ongoing research,unassigned 1,2,0 3.4.22.53 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25990280&form=6&db=m Transcriptional regulation of calcium-activated neutral protease in cardiomyocytes of hypertensive rats. causal interaction,unassigned 1,0 3.4.22.53 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20513182&form=6&db=m Gene expression of proteolytic systems and growth regulators of skeletal muscle in horses with myopathy associated with pituitary pars intermedia dysfunction. causal interaction,unassigned 3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600505&form=6&db=m Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907643&form=6&db=m Calpain-2 as a target for limiting prostate cancer invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466976&form=6&db=m Overexpression of m-calpain in human colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18234454&form=6&db=m NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene. causal interaction,unassigned 4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22629380&form=6&db=m Human U87 astrocytoma cell invasion induced by interaction of ?ig-h3 with integrin ?5?1 involves calpain-2. causal interaction,unassigned 3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23389291&form=6&db=m Regulation of proteolytic cleavage of retinoid X receptor-? by GSK-3? causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701654&form=6&db=m Epigallocatechin-3-gallate pretreatment attenuates doxorubicin-induced cardiotoxicity in rats: A mechanistic study. causal interaction,unassigned 2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28112201&form=6&db=m Novel Bioinformatics-Based Approach for Proteomic Biomarkers Prediction of Calpain-2 &Caspase-3 Protease Fragmentation: Application to ?II-Spectrin Protein. causal interaction,unassigned 3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29477696&form=6&db=m Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29909039&form=6&db=m Integrin ?6 and EGFR signaling converge at mechanosensitive calpain 2. causal interaction,unassigned 4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33321157&form=6&db=m pH-sensitive multi-drug liposomes targeting folate receptor ? for efficient treatment of non-small cell lung cancer. causal interaction,unassigned 4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33470511&form=6&db=m Calpain-calpastatin system and cancer progression. causal interaction,therapeutic application,unassigned 4,2,0 3.4.22.53 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m The calpain family and human disease. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.53 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10428767&form=6&db=m Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism. causal interaction,unassigned 3,0 3.4.22.53 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968209&form=6&db=m Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury. causal interaction,unassigned 3,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m The calpain family and human disease. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.53 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7632090&form=6&db=m Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29425806&form=6&db=m Hyperactivated m-calpain affects acquisition of doxorubicin resistance in breast cancer cells. diagnostic usage,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9196396&form=6&db=m Changes in calpain II mRNA in young rat lens during maturation and cataract formation. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964662&form=6&db=m Evidence for apoptosis in the selenite rat model of cataract. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28446133&form=6&db=m Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats. diagnostic usage,unassigned 2,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32703446&form=6&db=m Fatty acids influence the efficacy of lutein in the modulation of ?-crystallin chaperone function: Evidence from selenite induced cataract rat model. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.22.53 Corticobasal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506543&form=6&db=m Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140455&form=6&db=m Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21305563&form=6&db=m CALPAIN activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435971&form=6&db=m Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26076056&form=6&db=m Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29507677&form=6&db=m New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217905&form=6&db=m 1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32069035&form=6&db=m Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492240&form=6&db=m Cleavage of beta-catenin by calpain in prostate and mammary tumor cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.22.53 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8601625&form=6&db=m Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways. diagnostic usage,unassigned 2,0 3.4.22.53 Supranuclear Palsy, Progressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466976&form=6&db=m Overexpression of m-calpain in human colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.22.53 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23329366&form=6&db=m Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718565&form=6&db=m Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2072120&form=6&db=m Comparison of Ca(2+)-activated proteinase enzyme and endogenous inhibitor activity in brain tissue from normal and Alzheimer's disease cases. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23889979&form=6&db=m Hypoxia-Triggered m-Calpain Activation Evokes Endoplasmic Reticulum Stress and Neuropathogenesis in a Transgenic Mouse Model of Alzheimer's Disease. ongoing research,unassigned 2,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177812&form=6&db=m Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.53 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469158&form=6&db=m Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469158&form=6&db=m Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9804282&form=6&db=m Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats. ongoing research,unassigned 2,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18332219&form=6&db=m Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140455&form=6&db=m Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29848352&form=6&db=m Cytoplasmic FOXP1 expression is correlated with ER and calpain II expression and predicts a poor outcome in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279968&form=6&db=m Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 calpain-2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26076056&form=6&db=m Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26076056&form=6&db=m Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29210197&form=6&db=m Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466976&form=6&db=m Overexpression of m-calpain in human colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26076056&form=6&db=m Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29210197&form=6&db=m Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Head Injuries, Closed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612919&form=6&db=m Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor. ongoing research,therapeutic application,unassigned 3,2,0 3.4.22.53 Heart Valve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26955728&form=6&db=m [Calpain-2 and calcineurin protein expression in right atrial appendages from patients underwent valve replacement with or without atrial fibrillation]. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.22.53 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323818&form=6&db=m The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.22.53 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865282&form=6&db=m Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.22.53 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032335&form=6&db=m Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats. ongoing research,therapeutic application,unassigned 2,2,0 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506543&form=6&db=m Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22183788&form=6&db=m Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. causal interaction,ongoing research,unassigned 4,3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23733271&form=6&db=m Calpains are required for invasive and metastatic potentials of human HCC cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.53 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335024&form=6&db=m Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,3 3.4.22.53 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435971&form=6&db=m Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.53 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448882&form=6&db=m Calpain system protein expression and activity in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.22.53 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737623&form=6&db=m Expression of Syk and MAP4 proteins in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.22.53 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22787216&form=6&db=m Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.22.53 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32144989&form=6&db=m Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2 Cleavage. ongoing research,unassigned 4,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9654354&form=6&db=m m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27185592&form=6&db=m Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33339205&form=6&db=m Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death. causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322214&form=6&db=m Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22745213&form=6&db=m Calpain system protein expression in basal-like and triple-negative invasive breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25539577&form=6&db=m Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323818&form=6&db=m The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1440613&form=6&db=m Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1608594&form=6&db=m Hydration and elevated calcium alone do not produce xylose nuclear cataract: role of proteolysis by calpain. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848210&form=6&db=m Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2209751&form=6&db=m Calpain II in two in vivo models of sugar cataract. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2820891&form=6&db=m Regional distribution of free calcium in selenite cataract: relation to calpain II. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2998702&form=6&db=m Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10067969&form=6&db=m Modifications to rat lens major intrinsic protein in selenite-induced cataract. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362498&form=6&db=m Role of calpains in diabetes mellitus-induced cataractogenesis: a mini review. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14749260&form=6&db=m Structure, activation, and biology of calpain. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.53 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861418&form=6&db=m Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22665935&form=6&db=m Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23733271&form=6&db=m Calpains are required for invasive and metastatic potentials of human HCC cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.53 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29601651&form=6&db=m Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-?B/DNMT1 signaling pathway. ongoing research,therapeutic application,unassigned 4,1,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10806331&form=6&db=m Calpain-3 gene expression is decreased during experimental cancer cachexia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16652152&form=6&db=m Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29210197&form=6&db=m Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279968&form=6&db=m Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861418&form=6&db=m Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393869&form=6&db=m The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907643&form=6&db=m Calpain-2 as a target for limiting prostate cancer invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865282&form=6&db=m Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24297527&form=6&db=m Prolonged androgen deprivation leads to overexpression of calpain 2: implications for prostate cancer progression. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29601651&form=6&db=m Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-?B/DNMT1 signaling pathway. ongoing research,therapeutic application,unassigned 4,1,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31969640&form=6&db=m Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.53 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927135&form=6&db=m Comparison of the protein expression of calpain-1, calpain-2, calpastatin and calmodulin between gastric cancer and normal gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.4.22.53 Supranuclear Palsy, Progressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19251930&form=6&db=m Influence of glutamine infusion on ubiquitin, caspase-3, cathepsins L and B, and m-calpain expression in sheep with nutritionally induced metabolic acidosis. ongoing research,unassigned 1,0 3.4.22.53 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32937436&form=6&db=m Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment. unassigned - 3.4.22.53 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085852&form=6&db=m Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis. therapeutic application,unassigned 1,0 3.4.22.53 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19720936&form=6&db=m Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms. causal interaction,unassigned 1,0 3.4.22.53 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23977256&form=6&db=m Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.22.53 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33761765&form=6&db=m Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.22.53 Arsenic Poisoning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24641850&form=6&db=m [Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25]. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.53 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501405&form=6&db=m Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs. ongoing research,unassigned 4,0 3.4.22.53 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600505&form=6&db=m Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.22.53 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963167&form=6&db=m Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.53 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18182058&form=6&db=m Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques. unassigned - 3.4.22.53 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22064597&form=6&db=m m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.22.53 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26966280&form=6&db=m Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.22.53 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26955728&form=6&db=m [Calpain-2 and calcineurin protein expression in right atrial appendages from patients underwent valve replacement with or without atrial fibrillation]. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9637408&form=6&db=m pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10818755&form=6&db=m Casein zymogram assessment of mu-calpain and m-calpain activity after traumatic brain injury in the rat in vivo. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270371&form=6&db=m Degradation of ?II-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions. therapeutic application,unassigned 1,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28975597&form=6&db=m Erratum to: Degradation of ?II-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions. therapeutic application,unassigned 1,0 3.4.22.53 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16524385&form=6&db=m Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.53 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17712625&form=6&db=m Neuroprotective mechanism of taurine due to up-regulating calpastatin and down-regulating calpain and caspase-3 during focal cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.22.53 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20298691&form=6&db=m RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25486428&form=6&db=m Hematopoietic PBX-interacting protein (HPIP) is over expressed in breast infiltrative ductal carcinoma and regulates cell adhesion and migration through modulation of focal adhesion dynamics. unassigned - 3.4.22.53 Brucellosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25258171&form=6&db=m Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.53 calpain-2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26966280&form=6&db=m Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.22.53 calpain-2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30617810&form=6&db=m Genetic Models of Calpain Deficiency and Ectopic Expression. causal interaction,ongoing research,unassigned 3,3,0 3.4.22.53 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279968&form=6&db=m Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29099266&form=6&db=m Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration. therapeutic application,unassigned 1,0 3.4.22.53 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16023761&form=6&db=m Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma. causal interaction,ongoing research,unassigned 3,1,0 3.4.22.53 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21861846&form=6&db=m Apoptosis by aloe-emodin is mediated through downregulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells. unassigned - 3.4.22.53 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23733271&form=6&db=m Calpains are required for invasive and metastatic potentials of human HCC cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.53 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471877&form=6&db=m Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. causal interaction,ongoing research,unassigned 4,1,0 3.4.22.53 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662353&form=6&db=m Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway. ongoing research,unassigned 2,0 3.4.22.53 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32069035&form=6&db=m Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393065&form=6&db=m Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction. diagnostic usage,therapeutic application,unassigned 3,2,0 3.4.22.53 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25634181&form=6&db=m Cardiac protective effects of dexrazoxane on animal cardiotoxicity model induced by anthracycline combined with trastuzumab is associated with upregulation of calpain-2. causal interaction,therapeutic application,unassigned 3,3,0 3.4.22.53 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30810770&form=6&db=m Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity. ongoing research,unassigned 1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1627659&form=6&db=m Calpain II induced insolubilization of lens beta-crystallin polypeptides may induce cataract. causal interaction,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536646&form=6&db=m Calpain II in human lens. causal interaction,unassigned 4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011481&form=6&db=m Purification of calpain II from rat lens and determination of endogenous substrates. causal interaction,unassigned 4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3036741&form=6&db=m Origin of urea-soluble protein in the selenite cataract. Role of beta-crystallin proteolysis and calpain II. unassigned - 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7821381&form=6&db=m Calpains in lens epithelium from patients with cataract. causal interaction,unassigned 1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7859826&form=6&db=m Buthionine sulfoximine induced cataracts in mice contain insolubilized crystallins with calpain II cleavage sites. unassigned - 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8125740&form=6&db=m Cataract and the acceleration of calpain-induced beta-crystallin insolubilization occurring during normal maturation of rat lens. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395520&form=6&db=m alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract. ongoing research,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8405363&form=6&db=m Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract. causal interaction,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9733588&form=6&db=m Protein for Lp82 calpain is expressed and enzymatically active in young rat lens. causal interaction,unassigned 1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10694893&form=6&db=m Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82. causal interaction,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10798663&form=6&db=m Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice. causal interaction,unassigned 2,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12118077&form=6&db=m Mass measurements of C-terminally truncated alpha-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens. ongoing research,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12133374&form=6&db=m [The expression of calpain II in rat lens epithelial cells of hydrogen peroxide-induced cataract] causal interaction,ongoing research,unassigned 4,4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12212842&form=6&db=m General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice. unassigned - 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12658553&form=6&db=m Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). causal interaction,unassigned 4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151322&form=6&db=m Calpains and their multiple roles in diabetes mellitus. causal interaction,ongoing research,unassigned 2,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17460283&form=6&db=m Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains. causal interaction,unassigned 2,0 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29507677&form=6&db=m New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29722369&form=6&db=m Correction: New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.22.53 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612919&form=6&db=m Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor. ongoing research,therapeutic application,unassigned 3,2,0 3.4.22.53 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20683020&form=6&db=m Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer. diagnostic usage,unassigned 1,0 3.4.22.53 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33132163&form=6&db=m Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.22.53 Eye Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12212842&form=6&db=m General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice. unassigned - 3.4.22.53 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32937436&form=6&db=m Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment. unassigned - 3.4.22.53 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20730561&form=6&db=m Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22183788&form=6&db=m Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. causal interaction,ongoing research,unassigned 4,3,0 3.4.22.53 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070662&form=6&db=m Cellular distribution of proteolytic enzymes in the skeletal muscle of sarcoid myopathy. unassigned - 3.4.22.53 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968209&form=6&db=m Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury. causal interaction,unassigned 3,0 3.4.22.53 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31680308&form=6&db=m CAPN2 acts as an indicator of hepatitis B virus to induce hepatic fibrosis. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.22.53 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25150005&form=6&db=m Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28050125&form=6&db=m Somatostatin protects photoreceptor cells against high glucose-induced apoptosis. therapeutic application,unassigned 1,0 3.4.22.53 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843744&form=6&db=m Euglycemic hyperinsulinemia and hyperaminoacidemia decrease skeletal muscle ubiquitin mRNA in goats. ongoing research,unassigned 3,0 3.4.22.53 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460542&form=6&db=m Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. causal interaction,unassigned 4,0 3.4.22.53 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29477696&form=6&db=m Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.53 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26248159&form=6&db=m Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.22.53 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19884190&form=6&db=m Calcium-dependent cleavage of the Na(+)/Ca(2+) exchanger by m-calpain in isolated endoplasmic reticulum. unassigned - 3.4.22.53 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20372982&form=6&db=m m-Calpain-mediated cleavage of Na(+)/Ca (2+) exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle. unassigned - 3.4.22.53 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1527057&form=6&db=m Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.22.53 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032503&form=6&db=m Calpain 1 and 2 are required for RNA replication of echovirus 1. therapeutic application,unassigned 1,0 3.4.22.53 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1527057&form=6&db=m Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.22.53 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2203051&form=6&db=m Gene expression for calpain isozymes in human hematopoietic system cells. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.22.53 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23538341&form=6&db=m Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia. unassigned - 3.4.22.53 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471877&form=6&db=m Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. causal interaction,ongoing research,unassigned 4,1,0 3.4.22.53 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568240&form=6&db=m Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662353&form=6&db=m Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway. ongoing research,unassigned 2,0 3.4.22.53 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32069035&form=6&db=m Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17359359&form=6&db=m Cerebral calpain in fatal falciparum malaria. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.22.53 Marfan Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19720936&form=6&db=m Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms. causal interaction,unassigned 1,0 3.4.22.53 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177812&form=6&db=m Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.53 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9347985&form=6&db=m Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery. diagnostic usage,therapeutic application,unassigned 3,4,0 3.4.22.53 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056657&form=6&db=m Daily variations in dietary lysine content alter the expression of genes related to proteolysis in chicken pectoralis major muscle. unassigned - 3.4.22.53 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11371436&form=6&db=m Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain. unassigned - 3.4.22.53 Muscular Dystrophies, Limb-Girdle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11371436&form=6&db=m Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain. unassigned - 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498100&form=6&db=m Quantitative ELISA for platelet m-calpain: a phenotypic index for detection of carriers of Duchenne muscular dystrophy. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9798335&form=6&db=m Deletion analysis & calpain status for carrier detection in a family with Duchenne muscular dystrophy. diagnostic usage,unassigned 3,0 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16815350&form=6&db=m Altered expression, intracellular distribution and activity of lymphocyte calpain II in Duchenne muscular dystrophy. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22166894&form=6&db=m Platelet m-calpain: a facile marker and STR polymorphism analysis for the identification of true carriers of Duchenne muscular dystrophy. diagnostic usage,unassigned 2,0 3.4.22.53 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393065&form=6&db=m Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction. diagnostic usage,therapeutic application,unassigned 3,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8023339&form=6&db=m Strain-related differences in the pneumotoxic effects of chronically administered butylated hydroxytoluene on protein kinase C and calpain. causal interaction,ongoing research,unassigned 4,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9873017&form=6&db=m Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation. unassigned - 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10639123&form=6&db=m The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. unassigned - 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12184795&form=6&db=m Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity. causal interaction,unassigned 2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501405&form=6&db=m Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs. ongoing research,unassigned 4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16574073&form=6&db=m mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line. causal interaction,unassigned 3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18839313&form=6&db=m Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. unassigned - 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662353&form=6&db=m Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway. ongoing research,unassigned 2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31000696&form=6&db=m Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2. ongoing research,unassigned 3,0 3.4.22.53 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25150005&form=6&db=m Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29477696&form=6&db=m Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.53 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9160241&form=6&db=m Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.22.53 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854849&form=6&db=m Differential degradation of calpastatin by mu- and m-calpain in Ca(2+)-enriched human neuroblastoma LAN-5 cells. ongoing research,unassigned 3,0 3.4.22.53 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16524385&form=6&db=m Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.53 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32144989&form=6&db=m Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2 Cleavage. ongoing research,unassigned 4,0 3.4.22.53 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34014442&form=6&db=m Changes in activity of µ- and m-calpains and signs of neuroinflammation in the hippocampus and striatum of rats after single intraperitoneal injection of subseptic dose of endotoxin. causal interaction,therapeutic application,unassigned 2,3,0 3.4.22.53 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151322&form=6&db=m Calpains and their multiple roles in diabetes mellitus. causal interaction,ongoing research,unassigned 2,1,0 3.4.22.53 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600505&form=6&db=m Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.22.53 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17261541&form=6&db=m G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage. ongoing research,unassigned 4,0 3.4.22.53 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963167&form=6&db=m Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.53 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206508&form=6&db=m Calpain mediated cisplatin-induced ototoxicity in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.22.53 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27487486&form=6&db=m The calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.22.53 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10722997&form=6&db=m Calpastatin immunoreactivity in the monkey and human brain of control subjects and patients with Parkinson's disease. causal interaction,unassigned 4,0 3.4.22.53 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30078403&form=6&db=m Calpeptin attenuates cigarette smoke-induced pulmonary inflammation via suppressing calpain/I?B? signaling in mice and BEAS-2B cells. therapeutic application,unassigned 1,0 3.4.22.53 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33208557&form=6&db=m Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury. causal interaction,therapeutic application,unassigned 1,2,0 3.4.22.53 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15654835&form=6&db=m Autoantibodies directed against the protease inhibitor calpastatin in psoriasis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 3.4.22.53 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26248159&form=6&db=m Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.22.53 Rabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22903378&form=6&db=m RVG-Mediated Calpain2 Gene Silencing in the Brain Impairs Learning and Memory. ongoing research,unassigned 1,0 3.4.22.53 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622212&form=6&db=m Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice. ongoing research,unassigned 4,0 3.4.22.53 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186110&form=6&db=m M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.53 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33132163&form=6&db=m Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.22.53 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471877&form=6&db=m Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. causal interaction,ongoing research,unassigned 4,1,0 3.4.22.53 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31495081&form=6&db=m Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.4.22.53 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737623&form=6&db=m Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury. causal interaction,therapeutic application,unassigned 1,4,0 3.4.22.53 Spinal Cord Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16847592&form=6&db=m Degradation of spectrin via calpains in the ventral horn after transient spinal cord ischemia in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.53 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055788&form=6&db=m A key role for calpains in retinal ganglion cell death. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.53 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23958790&form=6&db=m Artesunate inhibits the growth of gastric cancer cells through the mechanism of promoting oncosis both in vitro and in vivo. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.53 Striatonigral Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m The calpain family and human disease. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.53 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12127682&form=6&db=m P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.22.53 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33841141&form=6&db=m Inhibition of Shear-Induced Platelet Aggregation by Xueshuantong via Targeting Piezo1 Channel-Mediated Ca2+ Signaling Pathway. therapeutic application,unassigned 1,0 3.4.22.53 Urinary Incontinence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19756344&form=6&db=m The role of calpain-calpastatin system in the development of stress urinary incontinence. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.22.53 Urinary Incontinence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115452&form=6&db=m miR-93?mediated collagen expression in stress urinary incontinence via calpain-2. unassigned - 3.4.22.53 Wolfram Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422446&form=6&db=m A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0