3.4.22.53 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19251930&form=6&db=m Influence of glutamine infusion on ubiquitin, caspase-3, cathepsins L and B, and m-calpain expression in sheep with nutritionally induced metabolic acidosis. ongoing research,unassigned 1,0 3.4.22.53 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466976&form=6&db=m Overexpression of m-calpain in human colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.22.53 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23329366&form=6&db=m Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1718565&form=6&db=m Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2072120&form=6&db=m Comparison of Ca(2+)-activated proteinase enzyme and endogenous inhibitor activity in brain tissue from normal and Alzheimer's disease cases. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9296555&form=6&db=m Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. causal interaction,ongoing research,unassigned 3,1,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9654354&form=6&db=m m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m The calpain family and human disease. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23889979&form=6&db=m Hypoxia-Triggered m-Calpain Activation Evokes Endoplasmic Reticulum Stress and Neuropathogenesis in a Transgenic Mouse Model of Alzheimer's Disease. ongoing research,unassigned 2,0 3.4.22.53 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177812&form=6&db=m Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.53 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32937436&form=6&db=m Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment. unassigned - 3.4.22.53 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085852&form=6&db=m Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis. therapeutic application,unassigned 1,0 3.4.22.53 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19720936&form=6&db=m Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms. causal interaction,unassigned 1,0 3.4.22.53 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23977256&form=6&db=m Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.22.53 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33761765&form=6&db=m Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.22.53 Arsenic Poisoning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24641850&form=6&db=m [Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25]. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.53 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7632090&form=6&db=m Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 3.4.22.53 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501405&form=6&db=m Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs. ongoing research,unassigned 4,0 3.4.22.53 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600505&form=6&db=m Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.22.53 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963167&form=6&db=m Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.53 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22629380&form=6&db=m Human U87 astrocytoma cell invasion induced by interaction of ?ig-h3 with integrin ?5?1 involves calpain-2. causal interaction,unassigned 3,0 3.4.22.53 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18182058&form=6&db=m Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques. unassigned - 3.4.22.53 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22064597&form=6&db=m m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.22.53 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26966280&form=6&db=m Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.22.53 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26955728&form=6&db=m [Calpain-2 and calcineurin protein expression in right atrial appendages from patients underwent valve replacement with or without atrial fibrillation]. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.22.53 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27185592&form=6&db=m Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.53 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469158&form=6&db=m Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469158&form=6&db=m Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9637408&form=6&db=m pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9804282&form=6&db=m Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats. ongoing research,unassigned 2,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10818755&form=6&db=m Casein zymogram assessment of mu-calpain and m-calpain activity after traumatic brain injury in the rat in vivo. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270371&form=6&db=m Degradation of ?II-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions. therapeutic application,unassigned 1,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28975597&form=6&db=m Erratum to: Degradation of ?II-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions. therapeutic application,unassigned 1,0 3.4.22.53 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33339205&form=6&db=m Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death. causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.53 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16524385&form=6&db=m Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.53 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17712625&form=6&db=m Neuroprotective mechanism of taurine due to up-regulating calpastatin and down-regulating calpain and caspase-3 during focal cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 3.4.22.53 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20298691&form=6&db=m RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322214&form=6&db=m Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18332219&form=6&db=m Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140455&form=6&db=m Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22745213&form=6&db=m Calpain system protein expression in basal-like and triple-negative invasive breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25486428&form=6&db=m Hematopoietic PBX-interacting protein (HPIP) is over expressed in breast infiltrative ductal carcinoma and regulates cell adhesion and migration through modulation of focal adhesion dynamics. unassigned - 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25539577&form=6&db=m Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323818&form=6&db=m The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29425806&form=6&db=m Hyperactivated m-calpain affects acquisition of doxorubicin resistance in breast cancer cells. diagnostic usage,unassigned 3,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29848352&form=6&db=m Cytoplasmic FOXP1 expression is correlated with ER and calpain II expression and predicts a poor outcome in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.22.53 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279968&form=6&db=m Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 Brucellosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25258171&form=6&db=m Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.53 calpain-2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 calpain-2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26966280&form=6&db=m Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.22.53 calpain-2 deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30617810&form=6&db=m Genetic Models of Calpain Deficiency and Ectopic Expression. causal interaction,ongoing research,unassigned 3,3,0 3.4.22.53 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279968&form=6&db=m Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335024&form=6&db=m Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,3 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435971&form=6&db=m Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29099266&form=6&db=m Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration. therapeutic application,unassigned 1,0 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228653&form=6&db=m Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.4.22.53 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448882&form=6&db=m Calpain system protein expression and activity in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.22.53 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16023761&form=6&db=m Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma. causal interaction,ongoing research,unassigned 3,1,0 3.4.22.53 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21861846&form=6&db=m Apoptosis by aloe-emodin is mediated through downregulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells. unassigned - 3.4.22.53 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23733271&form=6&db=m Calpains are required for invasive and metastatic potentials of human HCC cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.53 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471877&form=6&db=m Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. causal interaction,ongoing research,unassigned 4,1,0 3.4.22.53 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662353&form=6&db=m Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway. ongoing research,unassigned 2,0 3.4.22.53 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32069035&form=6&db=m Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393065&form=6&db=m Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction. diagnostic usage,therapeutic application,unassigned 3,2,0 3.4.22.53 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25634181&form=6&db=m Cardiac protective effects of dexrazoxane on animal cardiotoxicity model induced by anthracycline combined with trastuzumab is associated with upregulation of calpain-2. causal interaction,therapeutic application,unassigned 3,3,0 3.4.22.53 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30810770&form=6&db=m Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity. ongoing research,unassigned 1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1440613&form=6&db=m Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1608594&form=6&db=m Hydration and elevated calcium alone do not produce xylose nuclear cataract: role of proteolysis by calpain. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1627659&form=6&db=m Calpain II induced insolubilization of lens beta-crystallin polypeptides may induce cataract. causal interaction,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1848210&form=6&db=m Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2209751&form=6&db=m Calpain II in two in vivo models of sugar cataract. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2536646&form=6&db=m Calpain II in human lens. causal interaction,unassigned 4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2820891&form=6&db=m Regional distribution of free calcium in selenite cataract: relation to calpain II. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2998702&form=6&db=m Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011481&form=6&db=m Purification of calpain II from rat lens and determination of endogenous substrates. causal interaction,unassigned 4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3036741&form=6&db=m Origin of urea-soluble protein in the selenite cataract. Role of beta-crystallin proteolysis and calpain II. unassigned - 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7821381&form=6&db=m Calpains in lens epithelium from patients with cataract. causal interaction,unassigned 1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7859826&form=6&db=m Buthionine sulfoximine induced cataracts in mice contain insolubilized crystallins with calpain II cleavage sites. unassigned - 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8125740&form=6&db=m Cataract and the acceleration of calpain-induced beta-crystallin insolubilization occurring during normal maturation of rat lens. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8395520&form=6&db=m alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract. ongoing research,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8405363&form=6&db=m Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract. causal interaction,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9196396&form=6&db=m Changes in calpain II mRNA in young rat lens during maturation and cataract formation. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9733588&form=6&db=m Protein for Lp82 calpain is expressed and enzymatically active in young rat lens. causal interaction,unassigned 1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10067969&form=6&db=m Modifications to rat lens major intrinsic protein in selenite-induced cataract. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10694893&form=6&db=m Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82. causal interaction,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10798663&form=6&db=m Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice. causal interaction,unassigned 2,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964662&form=6&db=m Evidence for apoptosis in the selenite rat model of cataract. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12118077&form=6&db=m Mass measurements of C-terminally truncated alpha-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens. ongoing research,unassigned 3,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12133374&form=6&db=m [The expression of calpain II in rat lens epithelial cells of hydrogen peroxide-induced cataract] causal interaction,ongoing research,unassigned 4,4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12212842&form=6&db=m General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice. unassigned - 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12658553&form=6&db=m Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). causal interaction,unassigned 4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362498&form=6&db=m Role of calpains in diabetes mellitus-induced cataractogenesis: a mini review. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151322&form=6&db=m Calpains and their multiple roles in diabetes mellitus. causal interaction,ongoing research,unassigned 2,1,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17460283&form=6&db=m Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains. causal interaction,unassigned 2,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21950698&form=6&db=m Involvement of calpain 2 in ionomycin-induced cell death in cultured mouse lens epithelial cells. causal interaction,unassigned 4,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25052996&form=6&db=m Loss of calpastatin leads to activation of calpain in human lens epithelial cells. causal interaction,ongoing research,unassigned 1,2,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28446133&form=6&db=m Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats. diagnostic usage,unassigned 2,0 3.4.22.53 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32703446&form=6&db=m Fatty acids influence the efficacy of lutein in the modulation of ?-crystallin chaperone function: Evidence from selenite induced cataract rat model. diagnostic usage,ongoing research,unassigned 1,2,0 3.4.22.53 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26076056&form=6&db=m Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26076056&form=6&db=m Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29210197&form=6&db=m Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466976&form=6&db=m Overexpression of m-calpain in human colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26076056&form=6&db=m Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29210197&form=6&db=m Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29507677&form=6&db=m New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.22.53 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29722369&form=6&db=m Correction: New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.22.53 Corticobasal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612919&form=6&db=m Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor. ongoing research,therapeutic application,unassigned 3,2,0 3.4.22.53 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14749260&form=6&db=m Structure, activation, and biology of calpain. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.53 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861418&form=6&db=m Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22665935&form=6&db=m Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20683020&form=6&db=m Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer. diagnostic usage,unassigned 1,0 3.4.22.53 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33132163&form=6&db=m Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.22.53 Eye Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12212842&form=6&db=m General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice. unassigned - 3.4.22.53 Frontotemporal Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32937436&form=6&db=m Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment. unassigned - 3.4.22.53 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20730561&form=6&db=m Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22183788&form=6&db=m Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. causal interaction,ongoing research,unassigned 4,3,0 3.4.22.53 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070662&form=6&db=m Cellular distribution of proteolytic enzymes in the skeletal muscle of sarcoid myopathy. unassigned - 3.4.22.53 Head Injuries, Closed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612919&form=6&db=m Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor. ongoing research,therapeutic application,unassigned 3,2,0 3.4.22.53 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968209&form=6&db=m Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury. causal interaction,unassigned 3,0 3.4.22.53 Heart Valve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26955728&form=6&db=m [Calpain-2 and calcineurin protein expression in right atrial appendages from patients underwent valve replacement with or without atrial fibrillation]. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.22.53 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31680308&form=6&db=m CAPN2 acts as an indicator of hepatitis B virus to induce hepatic fibrosis. diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.22.53 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25150005&form=6&db=m Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28050125&form=6&db=m Somatostatin protects photoreceptor cells against high glucose-induced apoptosis. therapeutic application,unassigned 1,0 3.4.22.53 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8843744&form=6&db=m Euglycemic hyperinsulinemia and hyperaminoacidemia decrease skeletal muscle ubiquitin mRNA in goats. ongoing research,unassigned 3,0 3.4.22.53 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460542&form=6&db=m Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. causal interaction,unassigned 4,0 3.4.22.53 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29477696&form=6&db=m Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.53 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26248159&form=6&db=m Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.22.53 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19884190&form=6&db=m Calcium-dependent cleavage of the Na(+)/Ca(2+) exchanger by m-calpain in isolated endoplasmic reticulum. unassigned - 3.4.22.53 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20372982&form=6&db=m m-Calpain-mediated cleavage of Na(+)/Ca (2+) exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle. unassigned - 3.4.22.53 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25990280&form=6&db=m Transcriptional regulation of calcium-activated neutral protease in cardiomyocytes of hypertensive rats. causal interaction,unassigned 1,0 3.4.22.53 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1527057&form=6&db=m Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.22.53 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032503&form=6&db=m Calpain 1 and 2 are required for RNA replication of echovirus 1. therapeutic application,unassigned 1,0 3.4.22.53 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323818&form=6&db=m The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.4.22.53 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865282&form=6&db=m Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.22.53 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1527057&form=6&db=m Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.22.53 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2203051&form=6&db=m Gene expression for calpain isozymes in human hematopoietic system cells. diagnostic usage,ongoing research,unassigned 1,1,0 3.4.22.53 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23538341&form=6&db=m Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia. unassigned - 3.4.22.53 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471877&form=6&db=m Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. causal interaction,ongoing research,unassigned 4,1,0 3.4.22.53 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568240&form=6&db=m Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662353&form=6&db=m Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway. ongoing research,unassigned 2,0 3.4.22.53 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32069035&form=6&db=m Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17359359&form=6&db=m Cerebral calpain in fatal falciparum malaria. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.4.22.53 Marfan Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19720936&form=6&db=m Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms. causal interaction,unassigned 1,0 3.4.22.53 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177812&form=6&db=m Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.53 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9347985&form=6&db=m Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery. diagnostic usage,therapeutic application,unassigned 3,4,0 3.4.22.53 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056657&form=6&db=m Daily variations in dietary lysine content alter the expression of genes related to proteolysis in chicken pectoralis major muscle. unassigned - 3.4.22.53 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20513182&form=6&db=m Gene expression of proteolytic systems and growth regulators of skeletal muscle in horses with myopathy associated with pituitary pars intermedia dysfunction. causal interaction,unassigned 3,0 3.4.22.53 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032335&form=6&db=m Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats. ongoing research,therapeutic application,unassigned 2,2,0 3.4.22.53 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11371436&form=6&db=m Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain. unassigned - 3.4.22.53 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506543&form=6&db=m Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 3.4.22.53 Muscular Dystrophies, Limb-Girdle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11371436&form=6&db=m Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain. unassigned - 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9498100&form=6&db=m Quantitative ELISA for platelet m-calpain: a phenotypic index for detection of carriers of Duchenne muscular dystrophy. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9798335&form=6&db=m Deletion analysis & calpain status for carrier detection in a family with Duchenne muscular dystrophy. diagnostic usage,unassigned 3,0 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16815350&form=6&db=m Altered expression, intracellular distribution and activity of lymphocyte calpain II in Duchenne muscular dystrophy. diagnostic usage,ongoing research,unassigned 3,3,0 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22166894&form=6&db=m Platelet m-calpain: a facile marker and STR polymorphism analysis for the identification of true carriers of Duchenne muscular dystrophy. diagnostic usage,unassigned 2,0 3.4.22.53 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506543&form=6&db=m Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 3.4.22.53 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393065&form=6&db=m Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction. diagnostic usage,therapeutic application,unassigned 3,2,0 3.4.22.53 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23733271&form=6&db=m Calpains are required for invasive and metastatic potentials of human HCC cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.53 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29601651&form=6&db=m Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-?B/DNMT1 signaling pathway. ongoing research,therapeutic application,unassigned 4,1,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8023339&form=6&db=m Strain-related differences in the pneumotoxic effects of chronically administered butylated hydroxytoluene on protein kinase C and calpain. causal interaction,ongoing research,unassigned 4,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9873017&form=6&db=m Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation. unassigned - 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600505&form=6&db=m Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10639123&form=6&db=m The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. unassigned - 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10806331&form=6&db=m Calpain-3 gene expression is decreased during experimental cancer cachexia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12184795&form=6&db=m Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity. causal interaction,unassigned 2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907643&form=6&db=m Calpain-2 as a target for limiting prostate cancer invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466976&form=6&db=m Overexpression of m-calpain in human colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501405&form=6&db=m Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs. ongoing research,unassigned 4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16574073&form=6&db=m mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line. causal interaction,unassigned 3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16652152&form=6&db=m Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18234454&form=6&db=m NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene. causal interaction,unassigned 4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18839313&form=6&db=m Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. unassigned - 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140455&form=6&db=m Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21305563&form=6&db=m CALPAIN activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22183788&form=6&db=m Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. causal interaction,ongoing research,unassigned 4,3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427650&form=6&db=m Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435971&form=6&db=m Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22629380&form=6&db=m Human U87 astrocytoma cell invasion induced by interaction of ?ig-h3 with integrin ?5?1 involves calpain-2. causal interaction,unassigned 3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23389291&form=6&db=m Regulation of proteolytic cleavage of retinoid X receptor-? by GSK-3? causal interaction,therapeutic application,unassigned 3,4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23733271&form=6&db=m Calpains are required for invasive and metastatic potentials of human HCC cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701654&form=6&db=m Epigallocatechin-3-gallate pretreatment attenuates doxorubicin-induced cardiotoxicity in rats: A mechanistic study. causal interaction,unassigned 2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26076056&form=6&db=m Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28112201&form=6&db=m Novel Bioinformatics-Based Approach for Proteomic Biomarkers Prediction of Calpain-2 &Caspase-3 Protease Fragmentation: Application to ?II-Spectrin Protein. causal interaction,unassigned 3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29210197&form=6&db=m Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29477696&form=6&db=m Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29507677&form=6&db=m New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29909039&form=6&db=m Integrin ?6 and EGFR signaling converge at mechanosensitive calpain 2. causal interaction,unassigned 4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30279968&form=6&db=m Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662353&form=6&db=m Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway. ongoing research,unassigned 2,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31000696&form=6&db=m Baicalein inhibits fibronectin-induced epithelial-mesenchymal transition by decreasing activation and upregulation of calpain-2. ongoing research,unassigned 3,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217905&form=6&db=m 1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32069035&form=6&db=m Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33321157&form=6&db=m pH-sensitive multi-drug liposomes targeting folate receptor ? for efficient treatment of non-small cell lung cancer. causal interaction,unassigned 4,0 3.4.22.53 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33470511&form=6&db=m Calpain-calpastatin system and cancer progression. causal interaction,therapeutic application,unassigned 4,2,0 3.4.22.53 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m The calpain family and human disease. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.53 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25150005&form=6&db=m Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29477696&form=6&db=m Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.53 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9160241&form=6&db=m Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system. diagnostic usage,ongoing research,unassigned 3,4,0 3.4.22.53 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854849&form=6&db=m Differential degradation of calpastatin by mu- and m-calpain in Ca(2+)-enriched human neuroblastoma LAN-5 cells. ongoing research,unassigned 3,0 3.4.22.53 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16524385&form=6&db=m Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.53 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32144989&form=6&db=m Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2 Cleavage. ongoing research,unassigned 4,0 3.4.22.53 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861418&form=6&db=m Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.53 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34014442&form=6&db=m Changes in activity of µ- and m-calpains and signs of neuroinflammation in the hippocampus and striatum of rats after single intraperitoneal injection of subseptic dose of endotoxin. causal interaction,therapeutic application,unassigned 2,3,0 3.4.22.53 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151322&form=6&db=m Calpains and their multiple roles in diabetes mellitus. causal interaction,ongoing research,unassigned 2,1,0 3.4.22.53 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600505&form=6&db=m Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.4.22.53 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17261541&form=6&db=m G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage. ongoing research,unassigned 4,0 3.4.22.53 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963167&form=6&db=m Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis. diagnostic usage,ongoing research,unassigned 1,3,0 3.4.22.53 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206508&form=6&db=m Calpain mediated cisplatin-induced ototoxicity in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.4.22.53 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335024&form=6&db=m Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,3 3.4.22.53 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435971&form=6&db=m Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.53 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448882&form=6&db=m Calpain system protein expression and activity in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.22.53 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737623&form=6&db=m Expression of Syk and MAP4 proteins in ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.4.22.53 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27487486&form=6&db=m The calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0 3.4.22.53 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10722997&form=6&db=m Calpastatin immunoreactivity in the monkey and human brain of control subjects and patients with Parkinson's disease. causal interaction,unassigned 4,0 3.4.22.53 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30078403&form=6&db=m Calpeptin attenuates cigarette smoke-induced pulmonary inflammation via suppressing calpain/I?B? signaling in mice and BEAS-2B cells. therapeutic application,unassigned 1,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393869&form=6&db=m The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907643&form=6&db=m Calpain-2 as a target for limiting prostate cancer invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492240&form=6&db=m Cleavage of beta-catenin by calpain in prostate and mammary tumor cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865282&form=6&db=m Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24297527&form=6&db=m Prolonged androgen deprivation leads to overexpression of calpain 2: implications for prostate cancer progression. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29601651&form=6&db=m Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-?B/DNMT1 signaling pathway. ongoing research,therapeutic application,unassigned 4,1,0 3.4.22.53 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31969640&form=6&db=m Geranylated 4-phenylcoumarins extracted from Mesua elegans induced caspase-independent cell death in prostate cancer cell lines through calpain-2 and cathepsin B. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.53 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33208557&form=6&db=m Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury. causal interaction,therapeutic application,unassigned 1,2,0 3.4.22.53 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15654835&form=6&db=m Autoantibodies directed against the protease inhibitor calpastatin in psoriasis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 3.4.22.53 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26248159&form=6&db=m Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.4.22.53 Rabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22903378&form=6&db=m RVG-Mediated Calpain2 Gene Silencing in the Brain Impairs Learning and Memory. ongoing research,unassigned 1,0 3.4.22.53 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27622212&form=6&db=m Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice. ongoing research,unassigned 4,0 3.4.22.53 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186110&form=6&db=m M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation. causal interaction,ongoing research,unassigned 3,2,0 3.4.22.53 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33132163&form=6&db=m Calpain-2 activation in mouse hippocampus plays a critical role in seizure-induced neuropathology. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.22.53 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8601625&form=6&db=m Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways. diagnostic usage,unassigned 2,0 3.4.22.53 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10428767&form=6&db=m Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism. causal interaction,unassigned 3,0 3.4.22.53 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32968209&form=6&db=m Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury. causal interaction,unassigned 3,0 3.4.22.53 Severe Acute Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22787216&form=6&db=m Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 3.4.22.53 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471877&form=6&db=m Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. causal interaction,ongoing research,unassigned 4,1,0 3.4.22.53 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31495081&form=6&db=m Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.4.22.53 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737623&form=6&db=m Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury. causal interaction,therapeutic application,unassigned 1,4,0 3.4.22.53 Spinal Cord Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16847592&form=6&db=m Degradation of spectrin via calpains in the ventral horn after transient spinal cord ischemia in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.4.22.53 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055788&form=6&db=m A key role for calpains in retinal ganglion cell death. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.53 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23958790&form=6&db=m Artesunate inhibits the growth of gastric cancer cells through the mechanism of promoting oncosis both in vitro and in vivo. ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.53 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927135&form=6&db=m Comparison of the protein expression of calpain-1, calpain-2, calpastatin and calmodulin between gastric cancer and normal gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.4.22.53 Striatonigral Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516996&form=6&db=m The calpain family and human disease. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.53 Supranuclear Palsy, Progressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8809817&form=6&db=m Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0 3.4.22.53 Supranuclear Palsy, Progressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070670&form=6&db=m Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2 3.4.22.53 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12127682&form=6&db=m P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein. diagnostic usage,ongoing research,unassigned 2,3,0 3.4.22.53 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32144989&form=6&db=m Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2 Cleavage. ongoing research,unassigned 4,0 3.4.22.53 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33841141&form=6&db=m Inhibition of Shear-Induced Platelet Aggregation by Xueshuantong via Targeting Piezo1 Channel-Mediated Ca2+ Signaling Pathway. therapeutic application,unassigned 1,0 3.4.22.53 Urinary Incontinence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19756344&form=6&db=m The role of calpain-calpastatin system in the development of stress urinary incontinence. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 3.4.22.53 Urinary Incontinence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115452&form=6&db=m miR-93?mediated collagen expression in stress urinary incontinence via calpain-2. unassigned - 3.4.22.53 Wolfram Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422446&form=6&db=m A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0