3.4.22.49 Blast Crisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26087013&form=6&db=m Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy. causal interaction,therapeutic application,unassigned 1,2,0 3.4.22.49 Blast Crisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26937281&form=6&db=m c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18728194&form=6&db=m Overexpression of Separase induces aneuploidy and mammary tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19008095&form=6&db=m Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24276237&form=6&db=m MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24481326&form=6&db=m Genetically engineered ER? positive breast cancer mouse models. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25086634&form=6&db=m ESPL1 is a candidate oncogene of luminal B breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28177203&form=6&db=m Biology and insights into the role of cohesin protease separase in human malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28859055&form=6&db=m Separase is a marker for prognosis and mitotic activity in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29780443&form=6&db=m Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth. ongoing research,therapeutic application,unassigned 1,1,0 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30097312&form=6&db=m EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor-Positive Breast Cancer. unassigned - 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32337480&form=6&db=m Independent Validation of EarlyR Gene Signature in BIG 1-98: A Randomized, Double-Blind, Phase III Trial Comparing Letrozole and Tamoxifen as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor-Positive, Early Breast Cancer. ongoing research,therapeutic application,unassigned 1,1,0 3.4.22.49 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32546141&form=6&db=m A prognostic model based on cell-cycle control predicts outcome of breast cancer patients. unassigned - 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210788&form=6&db=m A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. causal interaction,unassigned 3,0 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18728194&form=6&db=m Overexpression of Separase induces aneuploidy and mammary tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351757&form=6&db=m Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19497291&form=6&db=m Development and validation of a fluorogenic assay to measure separase enzyme activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21799785&form=6&db=m Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24525869&form=6&db=m Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24792645&form=6&db=m Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28177203&form=6&db=m Biology and insights into the role of cohesin protease separase in human malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29165708&form=6&db=m Separase prevents genomic instability by controlling replication fork speed. causal interaction,therapeutic application,unassigned 3,1,0 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29370237&form=6&db=m Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.22.49 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32253454&form=6&db=m Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.22.49 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18616699&form=6&db=m Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.22.49 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18616699&form=6&db=m Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.22.49 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32277525&form=6&db=m Recommended Revisions to the National SEP-1 Sepsis Quality Measure: A commentary by the Society of Infectious Diseases Pharmacists on the Infectious Diseases Society of America Position Paper. unassigned - 3.4.22.49 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32374387&form=6&db=m CMS Measure Stewards' Assessment of the Infectious Diseases Society of America's Position Paper on SEP-1. therapeutic application,unassigned 1,0 3.4.22.49 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33282948&form=6&db=m TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.22.49 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24792645&form=6&db=m Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.49 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34512713&form=6&db=m ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.22.49 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33308056&form=6&db=m Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study. diagnostic usage,therapeutic application,unassigned 4,1,0 3.4.22.49 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16839882&form=6&db=m Resolution of chiasmata in oocytes requires separase-mediated proteolysis. ongoing research,unassigned 1,0 3.4.22.49 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19124608&form=6&db=m Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation. causal interaction,unassigned 4,0 3.4.22.49 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19497291&form=6&db=m Development and validation of a fluorogenic assay to measure separase enzyme activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.22.49 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21799785&form=6&db=m Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.22.49 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26267133&form=6&db=m Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.22.49 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26267133&form=6&db=m Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.22.49 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32253454&form=6&db=m Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 3.4.22.49 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29370237&form=6&db=m Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.22.49 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33308056&form=6&db=m Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study. diagnostic usage,therapeutic application,unassigned 4,1,0 3.4.22.49 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18616699&form=6&db=m Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 3.4.22.49 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21799785&form=6&db=m Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.4.22.49 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29370237&form=6&db=m Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.22.49 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30585827&form=6&db=m National Performance on the Medicare SEP-1 Sepsis Quality Measure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 3.4.22.49 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351757&form=6&db=m Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.49 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22819078&form=6&db=m A single mutation in Securin induces chromosomal instability and enhances cell invasion. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.49 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24276237&form=6&db=m MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.49 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32425694&form=6&db=m A Gleason score-related outcome model for human prostate cancer: a comprehensive study based on weighted gene co-expression network analysis. diagnostic usage,unassigned 4,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210788&form=6&db=m A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. causal interaction,unassigned 3,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18728194&form=6&db=m Overexpression of Separase induces aneuploidy and mammary tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351757&form=6&db=m Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19497291&form=6&db=m Development and validation of a fluorogenic assay to measure separase enzyme activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19665072&form=6&db=m A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement. causal interaction,unassigned 4,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22819078&form=6&db=m A single mutation in Securin induces chromosomal instability and enhances cell invasion. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22870341&form=6&db=m The Proteolytic Activity of Separase in BCR-ABL-Positive Cells Is Increased by Imatinib. unassigned - 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24276237&form=6&db=m MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas. causal interaction,diagnostic usage,unassigned 4,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24525869&form=6&db=m Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24675365&form=6&db=m Chromatin compaction by condensin I, intra-kinetochore stretch and tension, and anaphase onset, in collective spindle assembly checkpoint interaction. unassigned - 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24792645&form=6&db=m Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25086634&form=6&db=m ESPL1 is a candidate oncogene of luminal B breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26087013&form=6&db=m Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy. causal interaction,therapeutic application,unassigned 1,2,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26267133&form=6&db=m Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27530289&form=6&db=m Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27966791&form=6&db=m Separase: Function Beyond Cohesion Cleavage and an Emerging Oncogene. causal interaction,therapeutic application,unassigned 4,2,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28146474&form=6&db=m Molecular mechanism for the regulation of yeast separase by securin. causal interaction,therapeutic application,unassigned 4,4,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28177203&form=6&db=m Biology and insights into the role of cohesin protease separase in human malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28859055&form=6&db=m Separase is a marker for prognosis and mitotic activity in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29780443&form=6&db=m Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth. ongoing research,therapeutic application,unassigned 1,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29867452&form=6&db=m The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30305303&form=6&db=m Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation. unassigned - 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502641&form=6&db=m EarlyR signature predicts response to neoadjuvant chemotherapy in breast cancer. diagnostic usage,therapeutic application,unassigned 1,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31553567&form=6&db=m Identification of Bioactive Small Molecule Inhibitors of Separase. causal interaction,therapeutic application,unassigned 4,2,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31784093&form=6&db=m Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats. unassigned - 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31930961&form=6&db=m Stability and pharmacokinetics of separase inhibitor-Sepin-1 in Sprague-Dawley rats. causal interaction,therapeutic application,unassigned 3,3,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32071959&form=6&db=m Data set on Separase Inhibitor-Sepin-1 toxicity on organ weights, hematology and clinical parameters in Sprague-Dawley rats. therapeutic application,unassigned 3,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32499568&form=6&db=m Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion. ongoing research,unassigned 1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32932728&form=6&db=m The New Paradigm of Network Medicine to Analyze Breast Cancer Phenotypes. causal interaction,ongoing research,unassigned 1,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33252730&form=6&db=m Structure and Function of the Separase-Securin Complex. causal interaction,therapeutic application,unassigned 1,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33282948&form=6&db=m TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33472072&form=6&db=m Prolonged mitosis causes separase deregulation and chromosome nondisjunction. ongoing research,therapeutic application,unassigned 2,1,0 3.4.22.49 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34180834&form=6&db=m [Separase, a key-player of mitosis: A new target for cancer therapy?] therapeutic application,unassigned 4,0 3.4.22.49 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351757&form=6&db=m Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.49 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19497291&form=6&db=m Development and validation of a fluorogenic assay to measure separase enzyme activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.4.22.49 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22819078&form=6&db=m A single mutation in Securin induces chromosomal instability and enhances cell invasion. causal interaction,therapeutic application,unassigned 4,1,0 3.4.22.49 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24395789&form=6&db=m Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis. causal interaction,unassigned 2,0 3.4.22.49 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351757&form=6&db=m Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720289&form=6&db=m New Mandated Centers for Medicare and Medicaid Services Requirements for Sepsis Reporting: Caution from the Field. therapeutic application,unassigned 3,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27908335&form=6&db=m The Past, Present, and Future of the Centers for Medicare and Medicaid Services Quality Measure SEP-1: The Early Management Bundle for Severe Sepsis/Septic Shock. causal interaction,therapeutic application,unassigned 4,3,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28483129&form=6&db=m Accountability for Sepsis Treatment: The SEP-1 Core Measure. causal interaction,therapeutic application,unassigned 1,4,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789803&form=6&db=m Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL). diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032869&form=6&db=m SEP-1: A Sepsis Measure in Need of Resuscitation? therapeutic application,unassigned 1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29048513&form=6&db=m Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis. causal interaction,unassigned 1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29236094&form=6&db=m Hospital Perceptions of Medicare's Sepsis Quality Reporting Initiative. causal interaction,therapeutic application,unassigned 2,4,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29459977&form=6&db=m Evidence Underpinning the U.S. Government-Mandated Hemodynamic Interventions for Sepsis: A Systematic Review. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,2 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29932042&form=6&db=m Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure. diagnostic usage,unassigned 2,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30015667&form=6&db=m Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30585827&form=6&db=m National Performance on the Medicare SEP-1 Sepsis Quality Measure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30702476&form=6&db=m Nurse Influence in Meeting Compliance With the Centers for Medicare and Medicaid Services Quality Measure: Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1). causal interaction,therapeutic application,unassigned 2,1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31226883&form=6&db=m Association of Hospital Characteristics With Early SEP-1 Performance. unassigned - 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31301874&form=6&db=m Implementation of an adult code sepsis protocol and its impact on SEP-1 core measure perfect score attainment in the ED. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31369426&form=6&db=m Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1). ongoing research,therapeutic application,unassigned 3,1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31400737&form=6&db=m Sepsis quality in safety-net hospitals: An analysis of Medicare's SEP-1 performance measure. unassigned - 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31620463&form=6&db=m Influencing outcomes with automated time zero for sepsis through statistical validation and process improvement. causal interaction,unassigned 2,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932126&form=6&db=m Impact of SEP-1 on broad-spectrum combination antibiotic therapy in the emergency department. causal interaction,therapeutic application,unassigned 2,4,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32040837&form=6&db=m Adherence to the SEP-1 Sepsis Bundle in Hospital-Onset v. Community-Onset Sepsis: a Multicenter Retrospective Cohort Study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32148923&form=6&db=m Driving blind: instituting SEP-1 without high quality outcomes data. therapeutic application,unassigned 1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32166234&form=6&db=m Comparison of Automated Sepsis Identification Methods and Electronic Health Record-based Sepsis Phenotyping: Improving Case Identification Accuracy by Accounting for Confounding Comorbid Conditions. diagnostic usage,unassigned 2,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32250412&form=6&db=m Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32277525&form=6&db=m Recommended Revisions to the National SEP-1 Sepsis Quality Measure: A commentary by the Society of Infectious Diseases Pharmacists on the Infectious Diseases Society of America Position Paper. unassigned - 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32374861&form=6&db=m Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure. causal interaction,unassigned 2,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32433077&form=6&db=m SEP-1 Has Brought Much Needed Attention to Improving Sepsis Care…But Now Is the Time to Improve SEP-1. causal interaction,unassigned 2,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32520906&form=6&db=m Seeking a balanced approach to implementing sepsis guidelines. therapeutic application,unassigned 1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32827032&form=6&db=m Impact of the Centers for Medicare and Medicaid Services Sepsis Core Measure on Antibiotic Use. causal interaction,diagnostic usage,unassigned 4,3,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33041123&form=6&db=m Utilization of a multidisciplinary emergency department sepsis huddle to reduce time to antibiotics and improve SEP-1 compliance. therapeutic application,unassigned 1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33137539&form=6&db=m Comparison of an ED triage sepsis screening tool and qSOFA in identifying CMS SEP-1 patients. diagnostic usage,unassigned 1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309843&form=6&db=m Evaluation of hospital nurse-to-patient staffing ratios and sepsis bundles on patient outcomes. ongoing research,unassigned 1,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33738169&form=6&db=m Failure to Clear Intermediate Lactate Levels in Ward Patients With Admission Blood Cultures Did Not Increase the Risk of Intensive Care Unit Transfer or In-Hospital Mortality: A Retrospective Cohort Study. diagnostic usage,unassigned 2,0 3.4.22.49 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33872042&form=6&db=m Treatment Patterns and Clinical Outcomes After the Introduction of the Medicare Sepsis Performance Measure (SEP-1). causal interaction,therapeutic application,unassigned 2,1,0 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27720289&form=6&db=m New Mandated Centers for Medicare and Medicaid Services Requirements for Sepsis Reporting: Caution from the Field. therapeutic application,unassigned 3,0 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27908335&form=6&db=m The Past, Present, and Future of the Centers for Medicare and Medicaid Services Quality Measure SEP-1: The Early Management Bundle for Severe Sepsis/Septic Shock. causal interaction,therapeutic application,unassigned 4,3,0 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789803&form=6&db=m Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL). diagnostic usage,therapeutic application,unassigned 2,1,0 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29048513&form=6&db=m Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis. causal interaction,unassigned 1,0 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30015667&form=6&db=m Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31301874&form=6&db=m Implementation of an adult code sepsis protocol and its impact on SEP-1 core measure perfect score attainment in the ED. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932126&form=6&db=m Impact of SEP-1 on broad-spectrum combination antibiotic therapy in the emergency department. causal interaction,therapeutic application,unassigned 2,4,0 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32374861&form=6&db=m Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure. causal interaction,unassigned 2,0 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865547&form=6&db=m SEP-1 Septic Shock Bundle Guidelines Not Applicable to Inpatients. therapeutic application,unassigned 1,0 3.4.22.49 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865559&form=6&db=m SEP-1 Septic Shock Bundle Guidelines Not Applicable to Inpatients-Reply. therapeutic application,unassigned 1,0 3.4.22.49 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30305303&form=6&db=m Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation. unassigned - 3.4.22.49 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30585827&form=6&db=m National Performance on the Medicare SEP-1 Sepsis Quality Measure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 3.4.22.49 Thoracic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34277084&form=6&db=m Regarding Journal of Thoracic Disease Vol 12, Supplement 1 (February 2020) (Sepsis: Science and Fiction)-Driving blind: instituting SEP-1 without high quality outcomes data. unassigned -