3.4.18.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28078176&form=6&db=m The function of cathepsins B, D, and X in atherosclerosis. therapeutic application,unassigned 1,0 3.4.18.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162377&form=6&db=m Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.18.1 Alagille Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087368&form=6&db=m Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.18.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23621429&form=6&db=m Neuroprotective role of ?-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X. unassigned - 3.4.18.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30459560&form=6&db=m Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1?E9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease. causal interaction,ongoing research,unassigned 1,4,0 3.4.18.1 Bone Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31278293&form=6&db=m Cathepsin Z as a novel potential biomarker for osteoporosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.4.18.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133781&form=6&db=m Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. ongoing research,therapeutic application,unassigned 1,1,0 3.4.18.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162377&form=6&db=m Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.18.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025436&form=6&db=m Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.18.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152410&form=6&db=m IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.18.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23800510&form=6&db=m Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice. causal interaction,unassigned 2,0 3.4.18.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162377&form=6&db=m Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.18.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025436&form=6&db=m Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.18.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21966391&form=6&db=m Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.18.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32928870&form=6&db=m Deciphering the Plasma Proteome of Type 2 Diabetes. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.18.1 cathepsin x deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1920915&form=6&db=m Acid carboxypeptidase deficiency in galactosialidosis. causal interaction,unassigned 4,0 3.4.18.1 cathepsin x deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133781&form=6&db=m Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. ongoing research,therapeutic application,unassigned 1,1,0 3.4.18.1 cathepsin x deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21616554&form=6&db=m Cellular senescence induced by cathepsin X downregulation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.18.1 cathepsin x deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152410&form=6&db=m IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.18.1 Cholangitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087368&form=6&db=m Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.18.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23077459&form=6&db=m Cathepsin X in serum from patients with colorectal cancer: relation to prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.18.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24725597&form=6&db=m Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients. diagnostic usage,ongoing research,unassigned 4,3,0 3.4.18.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25442015&form=6&db=m Characterization of cathepsin X in colorectal cancer development and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.18.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31090199&form=6&db=m KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2 3.4.18.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32928870&form=6&db=m Deciphering the Plasma Proteome of Type 2 Diabetes. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.4.18.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21322635&form=6&db=m Development of Activity-Based Probes for Cathepsin X. causal interaction,therapeutic application,unassigned 3,2,0 3.4.18.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28486971&form=6&db=m A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 3.4.18.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28486971&form=6&db=m A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 3.4.18.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24657443&form=6&db=m Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics. causal interaction,diagnostic usage,unassigned 3,3,0 3.4.18.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025436&form=6&db=m Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.18.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19446361&form=6&db=m Cathepsin X prevents an effective immune response against Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,3 3.4.18.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367810&form=6&db=m Localization patterns of cathepsins K and X and their predictive value in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 3.4.18.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=704484&form=6&db=m Effect on vitamin A on the development of galactosamine-induced hepatitis in rats. ongoing research,unassigned 3,0 3.4.18.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5581599&form=6&db=m [Distribution and activity of lysosomal protein catabolic-enzymes of rat liver in galactosamine hepatitis: catepsin D, cathepsin A and acid carboxypeptidase] diagnostic usage,ongoing research,unassigned 3,3,0 3.4.18.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15196006&form=6&db=m Cathepsins K, L, B, X and W are differentially expressed in normal and chronically inflamed gastric mucosa. causal interaction,unassigned 2,0 3.4.18.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025436&form=6&db=m Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.18.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19446361&form=6&db=m Cathepsin X prevents an effective immune response against Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,3 3.4.18.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736174&form=6&db=m Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after helicobacter pylori infection. causal interaction,ongoing research,unassigned 2,4,0 3.4.18.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23811052&form=6&db=m Vaccine potential of recombinant cathepsin B against Fasciola gigantica. ongoing research,therapeutic application,unassigned 4,1,0 3.4.18.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31401060&form=6&db=m Generation of a single-chain variable fragment phage display antibody library from naïve mice panned against Fasciola hepatica antigens. causal interaction,therapeutic application,unassigned 3,2,0 3.4.18.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34508714&form=6&db=m Vaccination of mice with recombinant novel aminopeptidase P and cathepsin X alone or in combination induces protective immunity against Trichinella spiralis infection. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 3.4.18.1 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18949742&form=6&db=m Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 3.4.18.1 Intestinal Volvulus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14630920&form=6&db=m The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development. unassigned - 3.4.18.1 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087368&form=6&db=m Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.18.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087368&form=6&db=m Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.18.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878337&form=6&db=m Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.18.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28486971&form=6&db=m A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 3.4.18.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878337&form=6&db=m Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.18.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133781&form=6&db=m Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. ongoing research,therapeutic application,unassigned 1,1,0 3.4.18.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21966391&form=6&db=m Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8585423&form=6&db=m Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas. ongoing research,unassigned 2,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9642240&form=6&db=m Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162377&form=6&db=m Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878337&form=6&db=m Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025436&form=6&db=m Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707449&form=6&db=m Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133781&form=6&db=m Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. ongoing research,therapeutic application,unassigned 1,1,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21322635&form=6&db=m Development of Activity-Based Probes for Cathepsin X. causal interaction,therapeutic application,unassigned 3,2,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21616554&form=6&db=m Cellular senescence induced by cathepsin X downregulation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21966391&form=6&db=m Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23077459&form=6&db=m Cathepsin X in serum from patients with colorectal cancer: relation to prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152410&form=6&db=m IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells. causal interaction,therapeutic application,unassigned 4,1,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23326535&form=6&db=m Profilin 1 as a target for cathepsin X activity in tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23800510&form=6&db=m Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice. causal interaction,unassigned 2,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24835450&form=6&db=m Intracellular signaling by cathepsin X: Molecular mechanisms and diagnostic and therapeutic opportunities in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25274726&form=6&db=m Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. ongoing research,unassigned 3,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433997&form=6&db=m Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer. therapeutic application,unassigned 1,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25442015&form=6&db=m Characterization of cathepsin X in colorectal cancer development and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26325675&form=6&db=m Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis. therapeutic application,unassigned 1,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27889490&form=6&db=m Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28904354&form=6&db=m Identification and characterization of the novel reversible and selective cathepsin X inhibitors. therapeutic application,unassigned 1,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31409108&form=6&db=m Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32208223&form=6&db=m Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X. causal interaction,unassigned 4,0 3.4.18.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34378678&form=6&db=m Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.18.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23958447&form=6&db=m Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.18.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23077459&form=6&db=m Cathepsin X in serum from patients with colorectal cancer: relation to prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.4.18.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23958447&form=6&db=m Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.18.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28904354&form=6&db=m Identification and characterization of the novel reversible and selective cathepsin X inhibitors. therapeutic application,unassigned 1,0 3.4.18.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32208223&form=6&db=m Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X. causal interaction,unassigned 4,0 3.4.18.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33227497&form=6&db=m Human cathepsin X/Z is a biologically active homodimer. causal interaction,therapeutic application,unassigned 3,1,0 3.4.18.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33328882&form=6&db=m Neuroinflammation-Induced Upregulation of Glial Cathepsin X Expression and Activity in vivo. causal interaction,therapeutic application,unassigned 4,4,0 3.4.18.1 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25274726&form=6&db=m Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. ongoing research,unassigned 3,0 3.4.18.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27889490&form=6&db=m Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.4.18.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28486971&form=6&db=m A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3 3.4.18.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450037&form=6&db=m Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson's Disease. causal interaction,ongoing research,unassigned 3,1,0 3.4.18.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33328882&form=6&db=m Neuroinflammation-Induced Upregulation of Glial Cathepsin X Expression and Activity in vivo. causal interaction,therapeutic application,unassigned 4,4,0 3.4.18.1 Non-ST Elevated Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33396480&form=6&db=m Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI). causal interaction,diagnostic usage,unassigned 1,1,0 3.4.18.1 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31278293&form=6&db=m Cathepsin Z as a novel potential biomarker for osteoporosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.4.18.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22330678&form=6&db=m S100P-Binding Protein, S100PBP, Mediates Adhesion through Regulation of Cathepsin Z in Pancreatic Cancer Cells. unassigned - 3.4.18.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23958447&form=6&db=m Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.18.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450037&form=6&db=m Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson's Disease. causal interaction,ongoing research,unassigned 3,1,0 3.4.18.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23958447&form=6&db=m Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.4.18.1 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162377&form=6&db=m Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.18.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162377&form=6&db=m Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.4.18.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23326535&form=6&db=m Profilin 1 as a target for cathepsin X activity in tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.4.18.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32208223&form=6&db=m Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X. causal interaction,unassigned 4,0 3.4.18.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34378678&form=6&db=m Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.4.18.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087368&form=6&db=m Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. causal interaction,diagnostic usage,unassigned 1,3,0 3.4.18.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16025436&form=6&db=m Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.4.18.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19090485&form=6&db=m Regulation of cathepsin X overexpression in H. pylori-infected gastric epithelial cells and macrophages. causal interaction,unassigned 3,0 3.4.18.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20736174&form=6&db=m Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after helicobacter pylori infection. causal interaction,ongoing research,unassigned 2,4,0 3.4.18.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18420963&form=6&db=m Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. causal interaction,unassigned 1,0 3.4.18.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21354459&form=6&db=m Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study. diagnostic usage,unassigned 3,0 3.4.18.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21368909&form=6&db=m Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility. diagnostic usage,ongoing research,unassigned 3,2,0 3.4.18.1 Tuberculosis, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23827504&form=6&db=m Association of CTSZ rs34069356 and MC3R rs6127698 gene polymorphisms with pulmonary tuberculosis. ongoing research,unassigned 1,0