3.1.3.67 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28192480&form=6&db=m mTOR activity in AIDS-related diffuse large B-cell lymphoma. ongoing research,unassigned 1,0 3.1.3.67 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25844699&form=6&db=m Xenon Protects Against Septic Acute Kidney Injury via miR-21 Target Signaling Pathway. causal interaction,unassigned 1,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11146227&form=6&db=m Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695913&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16220831&form=6&db=m Expression of PTEN in ovarian epithelial tumors and its relation to tumor behavior and growth. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19007975&form=6&db=m PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas. causal interaction,unassigned 1,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19242756&form=6&db=m Expression of FAK and PTEN in Bronchioloalveolar carcinoma and lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19691991&form=6&db=m Histologic-Type Specific Role of Cell Cycle Regulators in Non-Small Cell Lung Carcinoma. ongoing research,unassigned 4,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20661135&form=6&db=m The mTOR pathway is frequently activated in pancreatic ductal adenocarcinoma and chronic pancreatitis. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285871&form=6&db=m Utilization of Unlabeled Probes for the Detection of Fibroblast Growth Factor Receptor 2 Exons 7 and 12 Mutations in Endometrial Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22753496&form=6&db=m JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23260327&form=6&db=m Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24035134&form=6&db=m Activation of Mammalian Target of Rapamycin Signaling Pathway Markers in Minute Adenocarcinoma of the Prostate. causal interaction,unassigned 1,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722320&form=6&db=m Construction and analysis of three networks of genes and microRNAs in adenocarcinoma. unassigned - 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27438514&form=6&db=m PTEN Expression in Mucinous Prostatic Adenocarcinoma, Prostatic Adenocarcinoma With Mucinous Features, and Adjacent Conventional Prostatic Adenocarcinoma: A Multiinstitutional Study of 92 Cases. causal interaction,unassigned 4,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27475963&form=6&db=m PTEN alterations of the stromal cells characterise an aggressive subpopulation of pancreatic cancer with enhanced metastatic potential. ongoing research,unassigned 3,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29621096&form=6&db=m PTEN Expression in Mucinous Prostatic Adenocarcinoma, Prostatic Adenocarcinoma With Mucinous Features, and Adjacent Conventional Prostatic Adenocarcinoma: A Multi-institutional Study of 92 Cases. causal interaction,unassigned 4,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30007089&form=6&db=m Expression of phosphatase and tensin homologue in imprint smears of endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,1 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30390196&form=6&db=m Expression of PTEN, Androgen Receptor, HER2/neu, Cytokeratin 5/6, Estrogen Receptor-Beta, HMGA2, and PLAG1 in Salivary Duct Carcinoma. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31864232&form=6&db=m Expression Profiles of the Phosphatase and Tensin Homolog (PTEN), CDH1, and CDH2 Genes, and the Cell Membrane Protein, CD133, in the Ishikawa Human Endometrial Adenocarcinoma Cell Line. ongoing research,unassigned 4,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32162714&form=6&db=m Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer. causal interaction,diagnostic usage,unassigned 1,4,0 3.1.3.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907203&form=6&db=m PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.1.3.67 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11146227&form=6&db=m Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.1.3.67 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982652&form=6&db=m Loss of Phosphatase and Tensin Homolog Protein Expression Is an Independent Poor Prognostic Marker in Lung Adenocarcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 3.1.3.67 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26323677&form=6&db=m MicroRNA-181a regulates epithelial-mesenchymal transition by targeting PTEN in drug-resistant lung adenocarcinoma cells. causal interaction,unassigned 3,0 3.1.3.67 Adenocarcinoma, Clear Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19007975&form=6&db=m PTEN promoter methylation and LOH of 10q22-23 locus in PTEN expression of ovarian clear cell adenocarcinomas. causal interaction,unassigned 1,0 3.1.3.67 Adenocarcinoma, Follicular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10741010&form=6&db=m Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.1.3.67 Adenocarcinoma, Follicular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30575166&form=6&db=m A case of follicular thyroid carcinoma associated with phosphatase and tensin homologue hamartoma tumour syndrome. causal interaction,unassigned 4,0 3.1.3.67 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9797362&form=6&db=m Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33535663&form=6&db=m An Immunohistochemical Study of the PTEN/AKT Pathway Involvement in Canine and Feline Mammary Tumors. ongoing research,unassigned 2,0 3.1.3.67 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30390196&form=6&db=m Expression of PTEN, Androgen Receptor, HER2/neu, Cytokeratin 5/6, Estrogen Receptor-Beta, HMGA2, and PLAG1 in Salivary Duct Carcinoma. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15021905&form=6&db=m Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. unassigned - 3.1.3.67 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24296317&form=6&db=m Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24532317&form=6&db=m Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells. causal interaction,therapeutic application,unassigned 1,3,0 3.1.3.67 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474162&form=6&db=m [Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis]. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30275180&form=6&db=m Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31024258&form=6&db=m Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28129112&form=6&db=m Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice. unassigned - 3.1.3.67 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30290714&form=6&db=m PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30611996&form=6&db=m A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.1.3.67 Ameloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18826385&form=6&db=m Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas. unassigned - 3.1.3.67 Ameloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32719259&form=6&db=m Role of phosphatase and tensin homolog in pathogenesis of ameloblastoma: An immunohistochemical study. ongoing research,unassigned 3,0 3.1.3.67 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22357537&form=6&db=m MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion. causal interaction,unassigned 3,0 3.1.3.67 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32383156&form=6&db=m MicroRNA-29a-3p regulates abdominal aortic aneurysm development and progression via direct interaction with PTEN. causal interaction,unassigned 3,0 3.1.3.67 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26307404&form=6&db=m Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis. causal interaction,ongoing research,unassigned 2,1,0 3.1.3.67 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30290714&form=6&db=m PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17982072&form=6&db=m PTEN down-regulates IL-17 expression in a murine model of toluene diisocyanate-induced airway disease. causal interaction,unassigned 4,0 3.1.3.67 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32889801&form=6&db=m PTEN participates in airway remodeling of asthma by regulating CD38/Ca2+/CREB signaling. causal interaction,unassigned 4,0 3.1.3.67 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9591629&form=6&db=m Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. causal interaction,unassigned 4,0 3.1.3.67 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15782140&form=6&db=m Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. unassigned - 3.1.3.67 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16003541&form=6&db=m Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. causal interaction,unassigned 3,0 3.1.3.67 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18088600&form=6&db=m S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. causal interaction,unassigned 1,0 3.1.3.67 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047102&form=6&db=m Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma. causal interaction,unassigned 4,0 3.1.3.67 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25197177&form=6&db=m Expression of phosphatase and tensin homolog, epidermal growth factor receptor, and Ki-67 in astrocytoma: A prospective study in a tertiary care hospital. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.1.3.67 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26701969&form=6&db=m miR-21 Is Linked to Glioma Angiogenesis: A Co-Localization Study. ongoing research,unassigned 2,0 3.1.3.67 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26919320&form=6&db=m Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel. causal interaction,unassigned 2,0 3.1.3.67 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30447426&form=6&db=m Retinal astrocytoma in a young male with PTEN hamartoma tumor syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29720545&form=6&db=m Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation. causal interaction,unassigned 4,0 3.1.3.67 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24532317&form=6&db=m Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells. causal interaction,therapeutic application,unassigned 1,3,0 3.1.3.67 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33802884&form=6&db=m Theasaponin E1 Inhibits Platinum-Resistant Ovarian Cancer Cells through Activating Apoptosis and Suppressing Angiogenesis. unassigned - 3.1.3.67 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22841663&form=6&db=m Increased stability of phosphatase and tensin homolog by intermedin leading to scavenger receptor A inhibition of macrophages reduces atherosclerosis in apolipoprotein E-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 3.1.3.67 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23068025&form=6&db=m Association of PTEN genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270534&form=6&db=m MiR-106b-5p Inhibits Tumor Necrosis Factor-?-induced Apoptosis by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 in Vascular Endothelial Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29908280&form=6&db=m LncRNA UCA1 sponges miR-26a to regulate the migration and proliferation of vascular smooth muscle cells. ongoing research,unassigned 2,0 3.1.3.67 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23983074&form=6&db=m Fibrosis caused by loss of PTEN expression by fibroblasts is crucially dependent on CCN2. causal interaction,unassigned 3,0 3.1.3.67 Azoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393046&form=6&db=m The expression of microRNAs and exposure to environmental contaminants related to human health: a review. ongoing research,unassigned 2,0 3.1.3.67 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20505137&form=6&db=m Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia. causal interaction,unassigned 2,0 3.1.3.67 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32220979&form=6&db=m PIP3 depletion rescues myoblast fusion defects in human rhabdomyosarcoma cells. ongoing research,unassigned 1,0 3.1.3.67 Bone Marrow Failure Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24124088&form=6&db=m Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25575796&form=6&db=m Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats. ongoing research,unassigned 2,0 3.1.3.67 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24312220&form=6&db=m Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.3.67 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30672370&form=6&db=m Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3K/AKT-mTOR signaling following traumatic spinal injuries. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816308&form=6&db=m Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499615&form=6&db=m Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.1.3.67 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17236582&form=6&db=m [Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors] causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 3.1.3.67 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17972252&form=6&db=m Why is PTEN an important tumor suppressor? causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18046441&form=6&db=m Mechanisms of Disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18524891&form=6&db=m Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. causal interaction,unassigned 4,0 3.1.3.67 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22079609&form=6&db=m The catalytic phosphoinositol 3-kinase isoform p110? is required for glioma cell migration and invasion. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28741261&form=6&db=m Hereditary breast cancer associated with Cowden syndrome-related PTEN mutation with Lhermitte-Duclos disease. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29340361&form=6&db=m A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34523696&form=6&db=m Targeting the mTOR pathway using novel ATP?competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma. causal interaction,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288766&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9490290&form=6&db=m A study of the PTEN/MMAC1 gene in 136 breast cancer families. ongoing research,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9509273&form=6&db=m Hereditary breast cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9510470&form=6&db=m Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671402&form=6&db=m Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9697884&form=6&db=m Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10472782&form=6&db=m Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10503872&form=6&db=m Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10741010&form=6&db=m Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297763&form=6&db=m PTEN/MMAC1 in malignant melanoma and its importance for tumor progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14518258&form=6&db=m [PTEN/MMAC1 is apparently not a relevant tumor suppressor gene in development of hereditary breast carcinoma] causal interaction,ongoing research,unassigned 1,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166282&form=6&db=m Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. causal interaction,unassigned 1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16425225&form=6&db=m Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone. unassigned - 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16517411&form=6&db=m Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parameters. diagnostic usage,ongoing research,unassigned 2,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17322919&form=6&db=m The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17393112&form=6&db=m Exogenous PTEN gene induces apoptosis in breast carcinoma cell line MDA468. ongoing research,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17420249&form=6&db=m Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cells. ongoing research,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18332865&form=6&db=m Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors. ongoing research,therapeutic application,unassigned 3,3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381417&form=6&db=m Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19435893&form=6&db=m Loss of Phosphatase and Tensin Homologue Deleted on Chromosome 10 Engages ErbB3 and Insulin-Like Growth Factor-I Receptor Signaling to Promote Antiestrogen Resistance in Breast Cancer. causal interaction,ongoing research,unassigned 3,3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843859&form=6&db=m Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells. causal interaction,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226014&form=6&db=m Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20554748&form=6&db=m PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20610632&form=6&db=m Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer. causal interaction,unassigned 3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20813970&form=6&db=m PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468554&form=6&db=m Estrogen receptor ? induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476875&form=6&db=m mTOR inhibition in breast cancer: unraveling the complex mechanisms of mTOR signal transduction and its clinical implications in therapy. causal interaction,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21552118&form=6&db=m Evaluation of Methods for Preserving PTEN Antigenicity in Stored Paraffin Sections. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801466&form=6&db=m Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172323&form=6&db=m PIK3CA mutations, PTEN, and pHER2 expression and impact on outcome in HER2-positive early-stage breast cancer patients treated with adjuvant chemotherapy and trastuzumab. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,2 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22350790&form=6&db=m Diagnostic potential of PTEN-targeting miR-214 in the blood of breast cancer patients. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22593441&form=6&db=m Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22744290&form=6&db=m PI3KCA mutations and/or PTEN loss in Her2-positive breast carcinomas treated with trastuzumab are not related to resistance to anti-Her2 therapy. unassigned - 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23574264&form=6&db=m The predictive role of phosphatase and tensin homolog (PTEN) loss, phosphoinositol-3 (PI3) kinase (PIK3CA) mutation, and PI3K pathway activation in sensitivity to trastuzumab in HER2-positive breast cancer: a meta-analysis. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24083111&form=6&db=m Expression of PIK3CA, PTEN mRNA and PIK3CA mutations in primary breast cancer: association with lymph node metastases. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24148769&form=6&db=m BAG5 regulates PTEN stability in MCF-7 cell line. causal interaction,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24296317&form=6&db=m Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24467828&form=6&db=m PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2 and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25056500&form=6&db=m Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapatinib plus paclitaxel or paclitaxel alone. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25212826&form=6&db=m Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25216078&form=6&db=m A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells. causal interaction,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25284585&form=6&db=m P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25364498&form=6&db=m MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN). ongoing research,unassigned 3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25417825&form=6&db=m MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NF?B-dependent pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25542038&form=6&db=m An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25556440&form=6&db=m 4-Hydroxynonenal promotes growth and angiogenesis of breast cancer cells through HIF-1? stabilization. causal interaction,unassigned 3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25849366&form=6&db=m Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines. ongoing research,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25851628&form=6&db=m Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) status. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26316702&form=6&db=m PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. therapeutic application,unassigned 1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26345302&form=6&db=m Physical Intimacy of Breast Cancer Cells with Mesenchymal Stem Cells Elicits Trastuzumab Resistance through Src Activation. causal interaction,therapeutic application,unassigned 2,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26623720&form=6&db=m Immunohistochemical prediction of lapatinib efficacy in advanced HER2-positive breast cancer patients. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629823&form=6&db=m Non-Specific Blocking of miR-17-5p Guide Strand in Triple Negative Breast Cancer Cells by Amplifying Passenger Strand Activity. unassigned - 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26665196&form=6&db=m [PI3K/AKT pathway activation and therapeutic consequences in breast cancer]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26705427&form=6&db=m MicroRNA-100 and microRNA-21 as markers of survival and chemotherapy response in pancreatic ductal adenocarcinoma UICC stage II. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26754093&form=6&db=m A study on promoter methylation of PTEN in sporadic breast cancer patients from North India. causal interaction,unassigned 3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26758558&form=6&db=m Integrated Analysis of PTEN and p4EBP1 Protein Expression as Predictors for pCR in HER2-Positive Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26951995&form=6&db=m The prognostic value of phosphatase and tensin homolog negativity in breast cancer: A systematic review and meta-analysis of 32 studies with 4393 patients. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465552&form=6&db=m PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27466505&form=6&db=m PTEN Insufficiency Increases Breast Cancer Cell Metastasis In Vitro and In Vivo in a Xenograft Zebrafish Model. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27620353&form=6&db=m The association between phosphatase and tensin homolog hypermethylation and patients with breast cancer, a meta-analysis and literature review. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27639383&form=6&db=m Addition of the p110? inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27672335&form=6&db=m The association of PTEN hypermethylation and breast cancer: a meta-analysis. causal interaction,ongoing research,unassigned 4,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27801993&form=6&db=m Predictive factors of the tumor immunological microenvironment for long-term follow-up in early stage breast cancer. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994679&form=6&db=m Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells. ongoing research,unassigned 2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28034453&form=6&db=m DNA damage repair in breast cancer and its therapeutic implications. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28105221&form=6&db=m Aberrant promoter methylation of cancer-related genes in human breast cancer. diagnostic usage,therapeutic application,unassigned 3,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28187748&form=6&db=m Characterization of ovarian clear cell carcinoma using target drug-based molecular biomarkers: implications for personalized cancer therapy. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28196852&form=6&db=m INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351303&form=6&db=m Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28739740&form=6&db=m Global Analysis of miRNA-mRNA Interaction Network in Breast Cancer with Brain Metastasis. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28844858&form=6&db=m miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-?B/COX-2 activation. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28885360&form=6&db=m The prognostic value and potential drug target of phosphatase and tensin homolog in breast cancer patients: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29566768&form=6&db=m Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29620260&form=6&db=m MicroRNA?142?5p modulates breast cancer cell proliferation and apoptosis by targeting phosphatase and tensin homolog. therapeutic application,unassigned 1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30702584&form=6&db=m The role of the phosphatase and tensin homolog status in predicting pathological complete response to neoadjuvant anti-HER2 therapies in HER2-positive primary breast cancer: A meta-analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30799775&form=6&db=m Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population. diagnostic usage,unassigned 3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30983514&form=6&db=m MiR-202-5p/PTEN mediates doxorubicin-resistance of breast cancer cells via PI3K/Akt signaling pathway. ongoing research,unassigned 4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31206626&form=6&db=m Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217901&form=6&db=m PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31595691&form=6&db=m In vivo longitudinal imaging of RNA interference-induced endocrine therapy resistance in breast cancer. diagnostic usage,ongoing research,unassigned 1,1,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32010404&form=6&db=m The Prognostic Significance of Phosphatase and Tensin Homolog Loss in Breast Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32509304&form=6&db=m Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review). unassigned - 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32765849&form=6&db=m Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review). diagnostic usage,unassigned 2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33003585&form=6&db=m Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332075&form=6&db=m Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells. causal interaction,unassigned 2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33402463&form=6&db=m Correlation Between Onco-suppressors PTEN and NM23 and Clinical Outcome in Patients With T1 Breast Cancer. diagnostic usage,ongoing research,unassigned 4,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33455095&form=6&db=m Overexpression of PIK3CA impacts global survival of patients with HER2 subtype breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33665980&form=6&db=m Development of the CK-MB-1 trastuzumab-resistant HER2-positive breast cancer cell line and xenograft animal models. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33816619&form=6&db=m Molecular Mechanism of Secondary Endocrine Resistance in Luminal Breast Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.1.3.67 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31922234&form=6&db=m Role and mechanism of PTEN in Burkitt's lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288766&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9439675&form=6&db=m Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9467947&form=6&db=m Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. ongoing research,unassigned 3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9510470&form=6&db=m Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671402&form=6&db=m Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765621&form=6&db=m Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10202180&form=6&db=m Are aberrant transcripts of FHIT, TSG101, and PTEN/MMAC1 oncogenesis related? causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10469123&form=6&db=m PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10470842&form=6&db=m Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485448&form=6&db=m Alterations of the PPP1R3 gene in human cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10492641&form=6&db=m Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract. causal interaction,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10637069&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10705874&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748870&form=6&db=m Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995879&form=6&db=m PTEN/MMAC1 expression in esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11395408&form=6&db=m PTEN and myotubularin: novel phosphoinositide phosphatases. causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585417&form=6&db=m Somatic mutations of the PTEN/NMAC1 gene associated with frequent chromosomal loss detected using comparative genomic hybridization in endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11801303&form=6&db=m Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110043&form=6&db=m Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12569572&form=6&db=m PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12678979&form=6&db=m [Expression of PTEN-encoding product in different stages of carcinogenesis and progression of gastric carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695913&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782594&form=6&db=m Loss of PTEN promotes tumor development in malignant melanoma. causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009714&form=6&db=m Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16061670&form=6&db=m Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170355&form=6&db=m Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16502258&form=6&db=m PTEN: A crucial mediator of mitochondria-dependent apoptosis. causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16574813&form=6&db=m Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441812&form=6&db=m Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17894887&form=6&db=m OncomiRs: the discovery and progress of microRNAs in cancers. therapeutic application,unassigned 1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17921358&form=6&db=m Conditional deletion of Pten causes bronchiolar hyperplasia. causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17927847&form=6&db=m [Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381417&form=6&db=m Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18551192&form=6&db=m Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. therapeutic application,unassigned 1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18774962&form=6&db=m Increased Activated Akt Expression in Renal Cell Carcinomas and Prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794802&form=6&db=m Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer. causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20079266&form=6&db=m [Mutation and expression of tumor suppressor gene phosphatase and tensin homolog deleted in chromosome 10 in oral squamous cell carcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197621&form=6&db=m A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. ongoing research,unassigned 2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20354178&form=6&db=m The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling. unassigned - 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20395448&form=6&db=m A Novel Three-Dimensional Culture System of Polarized Epithelial Cells to Study Endometrial Carcinogenesis. ongoing research,unassigned 2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20458142&form=6&db=m Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. unassigned - 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20534477&form=6&db=m A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21194879&form=6&db=m Clinical significance of tumor suppressor PTEN in colorectal carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21627959&form=6&db=m ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21719054&form=6&db=m Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells. therapeutic application,unassigned 1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561258&form=6&db=m PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3? signaling pathway in DMH induced early colon carcinogenesis in rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23013295&form=6&db=m Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23449497&form=6&db=m Predicting high risk disease using serum and DNA biomarkers. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520049&form=6&db=m Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. therapeutic application,unassigned 3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23552841&form=6&db=m Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23844610&form=6&db=m Radiation-associated small cell neuroendocrine carcinoma of the thyroid: a case report with molecular analyses. causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098737&form=6&db=m Four MicroRNAs Promote Prostate Cell Proliferation with Regulation of PTEN and Its Downstream Signals In Vitro. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24270409&form=6&db=m Sprouty1 induces a senescence-associated secretory phenotype by regulating NF?B activity: implications for tumorigenesis. causal interaction,unassigned 3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202365&form=6&db=m Concomitant depletion of PTEN and p27 and overexpression of cyclin D1 may predict a worse prognosis for patients with post-operative stage II and III colorectal cancer. diagnostic usage,unassigned 3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25425963&form=6&db=m Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25913390&form=6&db=m Genomic Predictors of Outcome in Prostate Cancer. causal interaction,ongoing research,unassigned 2,2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27983967&form=6&db=m MiR-200a acts as an oncogene in colorectal carcinoma by targeting PTEN. causal interaction,unassigned 2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27989760&form=6&db=m MiR-200a acts as an oncogene in colorectal carcinoma by targeting PTEN. causal interaction,unassigned 2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28671671&form=6&db=m Wnt/?-catenin activation and macrophage induction during liver cancer development following steatosis. therapeutic application,unassigned 2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28713947&form=6&db=m MicroRNA-582 promotes tumorigenesis by targeting phosphatase and tensin homologue in colorectal cancer. diagnostic usage,unassigned 2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399165&form=6&db=m Phosphorylation of phosphatase and tensin homolog induced by causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29400692&form=6&db=m Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. unassigned - 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29717770&form=6&db=m Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging. causal interaction,unassigned 1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858080&form=6&db=m Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30015845&form=6&db=m Downregulation of miR?486?5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30292635&form=6&db=m Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten-deficient mice. causal interaction,unassigned 2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30777076&form=6&db=m CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30834688&form=6&db=m Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53-dependent apoptosis and anticancer effect. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31010164&form=6&db=m The Antioxidant from Ethanolic Extract of Rosa cymosa Fruits Activates Phosphatase and Tensin Homolog In Vitro and In Vivo: A New Insight on Its Antileukemic Effect. unassigned - 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31115571&form=6&db=m Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31638194&form=6&db=m Assessment of biochemical recurrence of prostate cancer (Review). causal interaction,unassigned 1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31730755&form=6&db=m Loss of heterozygosity and immunoexpression of PTEN in oral epithelial dysplasia and squamous cell carcinoma. causal interaction,unassigned 4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31886238&form=6&db=m PTEN Inhibits Inflammatory Bone Loss in Ligature-Induced Periodontitis via IL1 and TNF-?. causal interaction,unassigned 3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31964643&form=6&db=m Metabolic Role of PTEN in Insulin Signaling and Resistance. causal interaction,unassigned 3,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32162714&form=6&db=m Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer. causal interaction,diagnostic usage,unassigned 1,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32512654&form=6&db=m Comprehensive Analysis of PTEN in Primary Cutaneous Melanoma. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33168448&form=6&db=m Effect of MicroRNA-766 Promotes Proliferation, Chemoresistance, Migration, and Invasion of Breast Cancer Cells. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34242625&form=6&db=m PTEN protects kidney against acute kidney injury by alleviating apoptosis and promoting autophagy via regulating HIF1-? and mTOR through PI3K/Akt pathway. causal interaction,unassigned 1,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34416231&form=6&db=m The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.1.3.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34447682&form=6&db=m Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription. therapeutic application,unassigned 1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671402&form=6&db=m Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696038&form=6&db=m Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung. diagnostic usage,unassigned 3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9778300&form=6&db=m Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9788441&form=6&db=m PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9829719&form=6&db=m Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499615&form=6&db=m Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10628321&form=6&db=m Somatic mutation and homozygous deletion of PTEN/MMAC1 gene of 10q23 in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657903&form=6&db=m Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748870&form=6&db=m Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766523&form=6&db=m Lack of deletions of the PTEN/MMAC1 and MXI1 loci in renal cell carcinoma by interphase cytogenetics. unassigned - 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778994&form=6&db=m Correspondence re: W.M. Lin et al., loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. Clin. Cancer Res., 4: 2577-2583, 1998. diagnostic usage,unassigned 1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995879&form=6&db=m PTEN/MMAC1 expression in esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093061&form=6&db=m Molecular genetic defects in endometriosis. causal interaction,unassigned 3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11463457&form=6&db=m Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma. ongoing research,unassigned 2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585417&form=6&db=m Somatic mutations of the PTEN/NMAC1 gene associated with frequent chromosomal loss detected using comparative genomic hybridization in endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11801303&form=6&db=m Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011252&form=6&db=m Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110043&form=6&db=m Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12678979&form=6&db=m [Expression of PTEN-encoding product in different stages of carcinogenesis and progression of gastric carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695913&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16191507&form=6&db=m Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505118&form=6&db=m Rosiglitazone suppresses human lung carcinoma cell growth through PPAR{gamma}-dependent and PPAR{gamma}-independent signal pathways. causal interaction,unassigned 3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17345711&form=6&db=m [Expression of two kinds of tumor correlation protein in laryngeal carcinoma and precancerous lesions] diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18587247&form=6&db=m Activation of PI3K is associated with reduced survival in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18776129&form=6&db=m Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19395652&form=6&db=m PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19470463&form=6&db=m Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19691991&form=6&db=m Histologic-Type Specific Role of Cell Cycle Regulators in Non-Small Cell Lung Carcinoma. ongoing research,unassigned 4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20079266&form=6&db=m [Mutation and expression of tumor suppressor gene phosphatase and tensin homolog deleted in chromosome 10 in oral squamous cell carcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20546613&form=6&db=m Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21104017&form=6&db=m Role of microRNA-21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma. ongoing research,unassigned 4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22240798&form=6&db=m Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22320969&form=6&db=m Altered expression of miR-21 and PTEN in human laryngeal and hypopharyngeal squamous cell carcinomas. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22596349&form=6&db=m Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23180960&form=6&db=m Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis? causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23273076&form=6&db=m High levels of phosphatase and tensin homolog expression are associated with tumor progression, tumor recurrence, and systemic metastases in pT1 urothelial carcinoma of the bladder: a tissue microarray study of 156 patients treated by transurethral resection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23321166&form=6&db=m Effect of PTEN Antisense Oligonucleotide on Oesophageal Squamous Cell Carcinoma Cell Lines. ongoing research,unassigned 4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23550155&form=6&db=m c-Myc phosphorylation by PKC? represses prostate tumorigenesis. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23601218&form=6&db=m Phosphorylated mammalian target of rapamycin is associated with an adverse outcome in oral squamous cell carcinoma. ongoing research,unassigned 3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24336158&form=6&db=m Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25003471&form=6&db=m PTEN expression in patients with carcinoma of the cervix and its association with p53, Ki-67 and CD31. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120657&form=6&db=m Phosphatase and tensin homolog overexpression decreases proliferation and invasion and increases apoptosis in oral squamous cell carcinoma cells. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25174622&form=6&db=m Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281027&form=6&db=m Chromosome 20q13.2 ZNF217 locus amplification correlates with decreased E-cadherin expression in ovarian clear cell carcinoma with PI3K-Akt pathway alterations. diagnostic usage,ongoing research,unassigned 2,2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25543611&form=6&db=m [Correlation analysis of VEGF and PTEN expression in gingival carcinoma]. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25622532&form=6&db=m Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25724185&form=6&db=m PTEN gene is infrequently hypermethylated in human esophageal squamous cell carcinoma. diagnostic usage,unassigned 1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750290&form=6&db=m Small Molecules Alter VEGFR and PTEN Expression in HPV-positive and -negative SCC: New Hope for Targeted-therapy. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789037&form=6&db=m Chemoresistance is associated with Beclin-1 and PTEN expression in epithelial ovarian cancers. diagnostic usage,ongoing research,unassigned 2,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25954860&form=6&db=m Low expression of phosphatase and tensin homolog in clear?cell renal cell carcinoma contributes to chemoresistance through activating the Akt/HDM2 signaling pathway. causal interaction,ongoing research,unassigned 2,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26541596&form=6&db=m Association of genetic polymorphisms in PTEN and additional gene-gene interaction with risk of esophageal squamous cell carcinoma in Chinese Han population. ongoing research,unassigned 3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26649861&form=6&db=m Upregulation of PTEN suppresses invasion in Tca8113 tongue cancer cells through repression of epithelial-mesenchymal transition (EMT). causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722456&form=6&db=m Prognostic role of PPAR-? and PTEN in the renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26725440&form=6&db=m Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma. ongoing research,unassigned 3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26731476&form=6&db=m Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870247&form=6&db=m Expression of PTEN and KAI1 tumor suppressor genes in pancreatic carcinoma and its association with different pathological factors. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27004535&form=6&db=m Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27347181&form=6&db=m Fentanyl inhibits the progression of human gastric carcinoma MGC-803 cells by modulating NF-?B-dependent gene expression in vivo. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27956548&form=6&db=m A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells. therapeutic application,unassigned 1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994422&form=6&db=m Immunohistochemical expression of phosphatase and tensin homolog in histologic gradings of oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28413152&form=6&db=m Loss of PTEN Expression Is Associated With High MicroRNA 24 Level and Poor Prognosis in Patients With Tongue Squamous Cell Carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28672019&form=6&db=m Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714370&form=6&db=m Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804548&form=6&db=m Overexpression of PTEN suppresses non-small-cell lung carcinoma metastasis through inhibition of integrin ?V?6 signaling. causal interaction,unassigned 4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28937318&form=6&db=m The crosstalk between p38 and Akt signaling pathways orchestrates EMT by regulating SATB2 expression in NSCLC cells. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28941804&form=6&db=m MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28951314&form=6&db=m Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. ongoing research,unassigned 2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29070781&form=6&db=m Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN phosphatase. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29463194&form=6&db=m The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29963173&form=6&db=m miR-222 promotes invasion and migration of ovarian carcinoma by targeting PTEN. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30270026&form=6&db=m Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer. ongoing research,unassigned 3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655739&form=6&db=m A clinical study on the expression of PTEN in renal cell carcinoma in children. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423242&form=6&db=m Correlation between PTEN gene polymorphism and oral squamous cell carcinoma. ongoing research,unassigned 4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31453348&form=6&db=m PTEN Is Associated With Worse Local Control in Early Stage Supraglottic Laryngeal Cancer Treated With Radiotherapy. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31548921&form=6&db=m Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31955800&form=6&db=m Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147068&form=6&db=m MiR-624-3p Promotes Esophageal Squamous Cell Carcinoma Progression via Targeting Phosphatase and Tensin Homologue. unassigned - 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33535663&form=6&db=m An Immunohistochemical Study of the PTEN/AKT Pathway Involvement in Canine and Feline Mammary Tumors. ongoing research,unassigned 2,0 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33959238&form=6&db=m PTEN and ?-SMA Expression and Diagnostic Role in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with Concomitant Oral Submucous Fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.1.3.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232796&form=6&db=m Molecular mechanism of microRNA-26a regulation of phosphatase and tensin homolog gene in condyloma acuminatum and penile squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Carcinoma, Adenosquamous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30100056&form=6&db=m Expression of phosphatase and tensin homolog and programmed cell death ligand 1 in adenosquamous carcinoma of the lung. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.1.3.67 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19080492&form=6&db=m [Expression of microRNA-21 in invasive ductal carcinoma of the breast and its association with phosphatase and tensin homolog deleted from chromosome expression and clinicopathologic features] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23665199&form=6&db=m Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinoma, Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15674339&form=6&db=m Loss of the tumor suppressor gene PTEN marks the transition from intratubular germ cell neoplasias (ITGCN) to invasive germ cell tumors. causal interaction,unassigned 3,0 3.1.3.67 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22503752&form=6&db=m Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor ?. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24071015&form=6&db=m Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928400&form=6&db=m Genetic analysis and phosphoinositide 3-kinase/protein kinase B signaling pathway status in ovarian endometrioid borderline tumor samples. causal interaction,unassigned 1,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340391&form=6&db=m PTEN/MMAC1 mutations in hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10363579&form=6&db=m PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10705874&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12575334&form=6&db=m [Relationship between the expression of PTEN protein and phosphorylation of MAPK in hepatocellular carcinomas and their surrounding liver tissues] causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15934306&form=6&db=m Correlation between loss of PTEN expression and PKB/AKT phosphorylation in hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16052674&form=6&db=m Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441812&form=6&db=m Epigenetic and genetic alterations of PTEN in hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17506947&form=6&db=m Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells. ongoing research,unassigned 4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17567478&form=6&db=m Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. ongoing research,unassigned 3,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17711623&form=6&db=m [Expressions of phosphorylated-Smad2 and PTEN in hepatocellular carcinomas and adjacent liver tissues] diagnostic usage,ongoing research,unassigned 2,2,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786367&form=6&db=m Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18176971&form=6&db=m Expression of phosphatase and tensin homolog deleted on chromosome ten in liver of athymic mice with hepatocellular carcinoma and the effect of Fuzheng Jiedu Decoction. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19082655&form=6&db=m Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20677905&form=6&db=m Radiation-inducible PTEN expression radiosensitises hepatocellular carcinoma cells. ongoing research,unassigned 2,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21520171&form=6&db=m Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance. causal interaction,unassigned 4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22949843&form=6&db=m Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23546593&form=6&db=m Expression and significance of PTEN and miR-92 in hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24187869&form=6&db=m Jianpijiedu fang improves survival of hepatocarcinoma mice by affecting phosphatase and tensin homolog, phosphoinositide 3-kinase, and focal adhesion kinase. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24633222&form=6&db=m Hepatitis B Virus Induces Cell Proliferation via HBx-Induced microRNA-21 in Hepatocellular Carcinoma by Targeting Programmed Cell Death Protein4 (PDCD4) and Phosphatase and Tensin Homologue (PTEN). diagnostic usage,ongoing research,unassigned 1,1,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25388655&form=6&db=m Hepatitis C virus NS5A drives a PTEN-PI3K/Akt feedback loop to support cell survival. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25447674&form=6&db=m Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog. causal interaction,unassigned 4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25613699&form=6&db=m PTEN and hTERT gene expression and the correlation with human hepatocellular carcinoma. ongoing research,unassigned 3,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25645159&form=6&db=m Inhibition of IRS-1 by hepatitis C virus infection leads to insulin resistance in a PTEN-dependent manner. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881591&form=6&db=m Phosphatase and tensin homologue genetic polymorphisms and their interactions with viral mutations on the risk of hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28411180&form=6&db=m Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28834734&form=6&db=m ONTD induces growth arrest and apoptosis of human hepatoma Bel-7402 cells though a peroxisome proliferator-activated receptor ?-dependent pathway. causal interaction,unassigned 4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28928809&form=6&db=m NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943966&form=6&db=m Ligands of the peroxisome proliferator-activated receptor ? inhibit hepatoce llular carcinoma cell proliferation. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29283497&form=6&db=m Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level. causal interaction,unassigned 4,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29393488&form=6&db=m Pterostilbene increases PTEN expression through the targeted downregulation of microRNA-19a in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30418964&form=6&db=m Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway. causal interaction,diagnostic usage,unassigned 2,2,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30431133&form=6&db=m Long non?coding RNA Fer?1?like family member 4 suppresses hepatocellular carcinoma cell proliferation by regulating PTEN in vitro and in vivo. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30834688&form=6&db=m Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53-dependent apoptosis and anticancer effect. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31126975&form=6&db=m Genetic alterations and expression of PTEN and its relationship with cancer stem cell markers to investigate pathogenesis and to evaluate prognosis in hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31564201&form=6&db=m Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway. diagnostic usage,unassigned 3,0 3.1.3.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 3.1.3.67 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23665199&form=6&db=m Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696041&form=6&db=m PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505118&form=6&db=m Rosiglitazone suppresses human lung carcinoma cell growth through PPAR{gamma}-dependent and PPAR{gamma}-independent signal pathways. causal interaction,unassigned 3,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281487&form=6&db=m Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18776129&form=6&db=m Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661141&form=6&db=m Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN. diagnostic usage,ongoing research,unassigned 2,4,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20211060&form=6&db=m [Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines] diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26166648&form=6&db=m High levels of phosphatase and tensin homolog expression predict favorable prognosis in patients with non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259304&form=6&db=m High levels of Phosphatase and Tensin Homolog Expression Predict Favorable Prognosis in Patients with Non-small Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506936&form=6&db=m PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature. causal interaction,unassigned 4,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27769862&form=6&db=m miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog. unassigned - 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263037&form=6&db=m Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804548&form=6&db=m Overexpression of PTEN suppresses non-small-cell lung carcinoma metastasis through inhibition of integrin ?V?6 signaling. causal interaction,unassigned 4,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28937318&form=6&db=m The crosstalk between p38 and Akt signaling pathways orchestrates EMT by regulating SATB2 expression in NSCLC cells. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29578164&form=6&db=m Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32452893&form=6&db=m Suberoylanilide hydroxamic acid overcomes erlotinib-acquired resistance via phosphatase and tensin homolog deleted on chromosome 10-mediated apoptosis in non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33467964&form=6&db=m Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression. ongoing research,unassigned 2,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33821441&form=6&db=m Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells. causal interaction,unassigned 3,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33904341&form=6&db=m The influence of circular RNAs on autophagy and disease progression. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34416231&form=6&db=m The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671402&form=6&db=m Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10628321&form=6&db=m Somatic mutation and homozygous deletion of PTEN/MMAC1 gene of 10q23 in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766523&form=6&db=m Lack of deletions of the PTEN/MMAC1 and MXI1 loci in renal cell carcinoma by interphase cytogenetics. unassigned - 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11463457&form=6&db=m Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma. ongoing research,unassigned 2,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011252&form=6&db=m Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18587247&form=6&db=m Activation of PI3K is associated with reduced survival in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25954860&form=6&db=m Low expression of phosphatase and tensin homolog in clear?cell renal cell carcinoma contributes to chemoresistance through activating the Akt/HDM2 signaling pathway. causal interaction,ongoing research,unassigned 2,3,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722456&form=6&db=m Prognostic role of PPAR-? and PTEN in the renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27956548&form=6&db=m A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells. therapeutic application,unassigned 1,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28672019&form=6&db=m Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29070781&form=6&db=m Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN phosphatase. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 3.1.3.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655739&form=6&db=m A clinical study on the expression of PTEN in renal cell carcinoma in children. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9778300&form=6&db=m Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748870&form=6&db=m Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995879&form=6&db=m PTEN/MMAC1 expression in esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11801303&form=6&db=m Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110043&form=6&db=m Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19691991&form=6&db=m Histologic-Type Specific Role of Cell Cycle Regulators in Non-Small Cell Lung Carcinoma. ongoing research,unassigned 4,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20546613&form=6&db=m Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22320969&form=6&db=m Altered expression of miR-21 and PTEN in human laryngeal and hypopharyngeal squamous cell carcinomas. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25003471&form=6&db=m PTEN expression in patients with carcinoma of the cervix and its association with p53, Ki-67 and CD31. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750290&form=6&db=m Small Molecules Alter VEGFR and PTEN Expression in HPV-positive and -negative SCC: New Hope for Targeted-therapy. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26649861&form=6&db=m Upregulation of PTEN suppresses invasion in Tca8113 tongue cancer cells through repression of epithelial-mesenchymal transition (EMT). causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28413152&form=6&db=m Loss of PTEN Expression Is Associated With High MicroRNA 24 Level and Poor Prognosis in Patients With Tongue Squamous Cell Carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30270026&form=6&db=m Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer. ongoing research,unassigned 3,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31955800&form=6&db=m Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34232796&form=6&db=m Molecular mechanism of microRNA-26a regulation of phosphatase and tensin homolog gene in condyloma acuminatum and penile squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Carcinoma, Verrucous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22690848&form=6&db=m Differential expression of microRNAs miR-21, miR-31, miR-203, miR-125a-5p and miR-125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck. diagnostic usage,ongoing research,unassigned 1,1,0 3.1.3.67 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18036354&form=6&db=m Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli. causal interaction,unassigned 4,0 3.1.3.67 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21954451&form=6&db=m Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy. causal interaction,therapeutic application,unassigned 2,3,0 3.1.3.67 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32370485&form=6&db=m [MicroRNA-23a knockdown attenuates angiotensin ? induced hypertrophy in rat H9c2 cells via activating PTEN and AMPK pathway]. ongoing research,therapeutic application,unassigned 1,1,0 3.1.3.67 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30095997&form=6&db=m PTEN Inhibitor VO-OHpic Attenuates Inflammatory M1 Macrophages and Cardiac Remodeling in Doxorubicin-Induced Cardiomyopathy. causal interaction,unassigned 3,0 3.1.3.67 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27747225&form=6&db=m Effect of Phosphatase and Tensin Homologue on Chromosome 10 on Angiotensin II-Mediated Proliferation, Collagen Synthesis, and Akt/P27 Signaling in Neonatal Rat Cardiac Fibroblasts. causal interaction,unassigned 4,0 3.1.3.67 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393046&form=6&db=m The expression of microRNAs and exposure to environmental contaminants related to human health: a review. ongoing research,unassigned 2,0 3.1.3.67 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24270425&form=6&db=m AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development. causal interaction,unassigned 4,0 3.1.3.67 Cerebellar Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852626&form=6&db=m A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor. causal interaction,unassigned 4,0 3.1.3.67 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31210323&form=6&db=m Effect of miR-130a on neuronal injury in rats with intracranial hemorrhage through PTEN/PI3K/AKT signaling pathway. ongoing research,unassigned 2,0 3.1.3.67 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31612303&form=6&db=m MicroRNA-26b/PTEN Signaling Pathway Mediates Glycine-Induced Neuroprotection in SAH Injury. unassigned - 3.1.3.67 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23068025&form=6&db=m Association of PTEN genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32104274&form=6&db=m miR-130a alleviates neuronal apoptosis and changes in expression of Bcl-2/Bax and caspase-3 in cerebral infarction rats through PTEN/PI3K/Akt signaling pathway. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21874010&form=6&db=m The expression of phospho-AKT1 and phospho-MTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas. ongoing research,unassigned 2,0 3.1.3.67 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22844568&form=6&db=m Sodium iodide symporter and phosphatase and tensin homolog deleted on chromosome ten expression in cholangiocarcinoma analysis with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0 3.1.3.67 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25239565&form=6&db=m miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.1.3.67 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30024792&form=6&db=m miR-132-3p boosts caveolae-mediated transcellular transport in glioma endothelial cells by targeting PTEN/PI3K/PKB/Src/Cav-1 signaling pathway. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535608&form=6&db=m Expression of PTEN and mTOR in sacral chordoma and association with poor prognosis. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23867870&form=6&db=m Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.1.3.67 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24882466&form=6&db=m Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) mice. ongoing research,unassigned 4,0 3.1.3.67 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29472916&form=6&db=m Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-374a Decreases Inflammation and Maintains Intestinal Barrier Function in Colitis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.1.3.67 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29788382&form=6&db=m Colonic Inhibition of Phosphatase and Tensin Homolog Increases Colitogenic Bacteria, Causing Development of Colitis in Il10-/- Mice. causal interaction,unassigned 3,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313308&form=6&db=m Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17545604&form=6&db=m Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. ongoing research,therapeutic application,unassigned 3,3,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19673018&form=6&db=m No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032390&form=6&db=m PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23725112&form=6&db=m Potential targets for prevention of colorectal cancer: a focus on PI3K/Akt/mTOR and Wnt pathways. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23798791&form=6&db=m Phosphatase and tensin homologue deleted on chromosome 10. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25873394&form=6&db=m Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-?B Pathway. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27543779&form=6&db=m Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30013659&form=6&db=m miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3? and Wnt/?-catenin signaling pathways. ongoing research,unassigned 3,0 3.1.3.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500630&form=6&db=m Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,4 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751500&form=6&db=m Colorectal carcinomas and PTEN/MMAC1 gene mutations. causal interaction,unassigned 4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15235134&form=6&db=m Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer. diagnostic usage,therapeutic application,unassigned 1,1,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19953097&form=6&db=m PTEN status in advanced colorectal cancer treated with cetuximab. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20947270&form=6&db=m KRAS and BRAF Mutations and PTEN Expression Do Not Predict Efficacy of Cetuximab-Based Chemoradiotherapy in Locally Advanced Rectal Cancer. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21078976&form=6&db=m MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21203412&form=6&db=m The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22690082&form=6&db=m Phosphatase and tensin homolog expression related to cetuximab effects in colorectal cancer patients: a meta-analysis. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23170117&form=6&db=m Relationship between expression and prognostic ability of PTEN, STAT3 and VEGF-C in colorectal cancer. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23174819&form=6&db=m MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells. ongoing research,unassigned 4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23617834&form=6&db=m MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells. causal interaction,ongoing research,unassigned 3,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23623571&form=6&db=m Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23930204&form=6&db=m Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24123284&form=6&db=m The relationship between and clinical significance of MicroRNA-32 and phosphatase and tensin homologue expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24187456&form=6&db=m Curcumin cytotoxicity is enhanced by PTEN disruption in colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,1 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24564252&form=6&db=m Can we accurately report PTEN status in advanced colorectal cancer? causal interaction,diagnostic usage,unassigned 1,4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24647592&form=6&db=m PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: Two hits on the gene? unassigned - 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24780321&form=6&db=m Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24862762&form=6&db=m NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane. causal interaction,unassigned 1,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24935469&form=6&db=m The association of phosphatase and tensin homolog deleted on chromosome 10 polymorphisms and lifestyle habits with colorectal cancer risk in a Chinese population. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25270723&form=6&db=m miR?494 is an independent prognostic factor and promotes cell migration and invasion in colorectal cancer by directly targeting PTEN. causal interaction,unassigned 1,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25603978&form=6&db=m MicroRNA-21 controls hTERT via PTEN in human colorectal cancer cell proliferation. ongoing research,unassigned 4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25861836&form=6&db=m FOLFIRI and Cetuximab Every Second Week for First-Line Treatment of KRAS Wild-Type Metastatic Colorectal Cancer According to Phosphatase and Tensin Homolog Expression: A Phase II Study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25986931&form=6&db=m A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancer. diagnostic usage,unassigned 4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26448020&form=6&db=m Combined Analysis of EGFR and PTEN Status in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26885116&form=6&db=m Association of genetic polymorphisms in PTEN and additional interaction with alcohol consumption and smoking on colorectal cancer in Chinese population. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27392434&form=6&db=m In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28713947&form=6&db=m MicroRNA-582 promotes tumorigenesis by targeting phosphatase and tensin homologue in colorectal cancer. diagnostic usage,unassigned 2,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28785174&form=6&db=m "Squirrel" Primer-Based PCR Assay for Direct and Targeted Sanger Sequencing of Short Genomic Segments. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29160937&form=6&db=m MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A. unassigned - 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29422975&form=6&db=m Assessment of PI3K/AKT/PTEN signaling pathway activity in colorectal cancer using quantum dot-conjugated antibodies. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186399&form=6&db=m Gambogic acid regulates the migration and invasion of colorectal cancer via microRNA-21-mediated activation of phosphatase and tensin homolog. diagnostic usage,unassigned 3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30849479&form=6&db=m Long noncoding RNA Linc02023 regulates PTEN stability and suppresses tumorigenesis of colorectal cancer in a PTEN-dependent pathway. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30936995&form=6&db=m Analysis of promoter methylation and epigenetic regulation of miR-32 in colorectal cancer cells. causal interaction,unassigned 4,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32146564&form=6&db=m MicroRNAs that regulate PTEN as potential biomarkers in colorectal cancer: a systematic review. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32321313&form=6&db=m Serum levels of PTEN mRNA in colorectal cancer: a case-control study. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33618627&form=6&db=m The roles of microbial products in the development of colorectal cancer: a review. ongoing research,unassigned 2,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33841568&form=6&db=m Transcription factor forkhead box K1 regulates miR-32 expression and enhances cell proliferation in colorectal cancer. causal interaction,unassigned 1,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33906293&form=6&db=m Evaluating the value of Amphiregulin, Phosphatase and Tensin Homologue (PTEN) and P21 Expression for Anti-EGFR Treatment in Metastatic Colorectal Carcinoma. diagnostic usage,therapeutic application,unassigned 3,2,0 3.1.3.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33933518&form=6&db=m A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Coronary Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32595526&form=6&db=m Serum Exosomal MicroRNA-21, MicroRNA-126, and PTEN Are Novel Biomarkers for Diagnosis of Acute Coronary Syndrome. diagnostic usage,ongoing research,unassigned 4,1,0 3.1.3.67 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23962154&form=6&db=m Activation of PI3K/Akt/mTOR signaling pathway triggered by PTEN downregulation in the pathogenesis of Crohn's disease. ongoing research,unassigned 1,0 3.1.3.67 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20929508&form=6&db=m Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20929508&form=6&db=m Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25659997&form=6&db=m Increased Plasma Levels of FABP4 and PTEN Is Associated with More Severe Insulin Resistance in Women with Gestational Diabetes Mellitus. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20929508&form=6&db=m Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21861051&form=6&db=m [Down-regulation of PTEN expression in kidney and its role in development of diabetic nephropathy in rats]. unassigned - 3.1.3.67 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29068796&form=6&db=m Protein phosphatases and podocyte function. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29361670&form=6&db=m Podocyte-Specific Knockin of PTEN Protects Kidney from Hyperglycemia. therapeutic application,unassigned 1,0 3.1.3.67 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32450680&form=6&db=m MiR-19a inhibitor improves diabetic retinopathy in rats through PTEN/Akt/P-Akt signaling pathway. ongoing research,unassigned 2,0 3.1.3.67 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609236&form=6&db=m miR-139-5p promotes neovascularization in diabetic retinopathy by regulating the phosphatase and tensin homolog. unassigned - 3.1.3.67 Diffuse Intrinsic Pontine Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872713&form=6&db=m Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event. therapeutic application,unassigned 1,0 3.1.3.67 Dysplastic Nevus Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27746632&form=6&db=m Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.1.3.67 Encephalitis, Japanese http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33724154&form=6&db=m Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26246144&form=6&db=m Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis. causal interaction,unassigned 1,0 3.1.3.67 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17085648&form=6&db=m Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17466036&form=6&db=m Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of rapamycin are associated with progesterone refractory endometrial hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 3.1.3.67 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20199355&form=6&db=m Prognostic significance of estrogen and progesterone receptor expression in LNG-IUS (Mirena) treatment of endometrial hyperplasia: an immunohistochemical study. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26637849&form=6&db=m Expression of PAX2 and PTEN Correlates to Therapy Response in Endometrial Hyperplasia. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29250656&form=6&db=m Immunohistochemical reaction of the glandular epithelium in endometrial hyperplasia compared to endometrial carcinoma. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31548921&form=6&db=m Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9354433&form=6&db=m PTEN/MMAC1 mutations in endometrial cancers. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765621&form=6&db=m Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9829719&form=6&db=m Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10564676&form=6&db=m Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657903&form=6&db=m Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585417&form=6&db=m Somatic mutations of the PTEN/NMAC1 gene associated with frequent chromosomal loss detected using comparative genomic hybridization in endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12781042&form=6&db=m Role of phosphatase PTEN in the activation of extracellular signal-regulated kinases induced by estradiol in endometrial carcinoma cells. ongoing research,unassigned 3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16542580&form=6&db=m Growth and activation of PI-3K/PKB and Akt by stromal cell-derived factor 1alpha in endometrial carcinoma cells with expression of suppressor endoprotein PTEN. causal interaction,unassigned 1,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17346540&form=6&db=m Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model. causal interaction,unassigned 3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18377423&form=6&db=m Correlation between NDRG1 and PTEN expression in endometrial carcinoma. causal interaction,unassigned 4,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18431720&form=6&db=m Diagnostic utility of phosphatase and tensin homolog, beta-catenin, and p53 for endometrial carcinoma by thin-layer endometrial preparations. causal interaction,diagnostic usage,unassigned 2,3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18451215&form=6&db=m Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19789507&form=6&db=m Expression of mTOR protein and its clinical significance in endometrial cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20418913&form=6&db=m The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. unassigned - 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20529558&form=6&db=m Phosphatase and tensin homolog gene inhibits the effect induced by gonadotropin-releasing hormone subtypes in human endometrial carcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20567148&form=6&db=m High-grade endometrial carcinoma: serous and grade 3 endometrioid carcinomas have different immunophenotypes and outcomes. diagnostic usage,ongoing research,unassigned 1,2,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20681032&form=6&db=m A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma. causal interaction,unassigned 3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21111454&form=6&db=m Promoter hypermethylation and expression of sprouty 2 in endometrial carcinoma. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21181309&form=6&db=m Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression. causal interaction,unassigned 2,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21788564&form=6&db=m Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group. causal interaction,unassigned 4,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22005521&form=6&db=m Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis? unassigned - 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226804&form=6&db=m microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer. ongoing research,unassigned 3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24023309&form=6&db=m ESR1 Gene Amplification in Endometrial Carcinomas: A Clinicopathological Analysis. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24071015&form=6&db=m Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24762589&form=6&db=m Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24929707&form=6&db=m MiR-205 inhibits cell apoptosis by targeting phosphatase and tensin homolog deleted on chromosome ten in endometrial cancer Ishikawa cells. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25266877&form=6&db=m Effect of mTOR inhibitors in nude mice with endometrial carcinoma and variable PTEN expression status. therapeutic application,unassigned 3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337560&form=6&db=m Steroid hormone intervenes in the endometrial tumorigenesis of pten ablation. causal interaction,unassigned 2,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468779&form=6&db=m Elevation of ?-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26678657&form=6&db=m Neuroendocrine Tumor of the Pancreas as a Manifestation of Cowden Syndrome: A Case Report. causal interaction,unassigned 4,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481051&form=6&db=m Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer. causal interaction,unassigned 4,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28220037&form=6&db=m Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28657664&form=6&db=m Conditional abrogation of transforming growth factor-? receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice. causal interaction,unassigned 1,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28945226&form=6&db=m PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29250656&form=6&db=m Immunohistochemical reaction of the glandular epithelium in endometrial hyperplasia compared to endometrial carcinoma. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30007089&form=6&db=m Expression of phosphatase and tensin homologue in imprint smears of endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,1 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30944646&form=6&db=m Expression of p53 and PTEN in human primary endometrial carcinomas: Clinicopathological and immunohistochemical analysis and study of their concomitant expression. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31548921&form=6&db=m Study of the Association of Phosphatase and Tensin Homolog and p27 Expressions in Endometrial Hyperplasia and Carcinoma. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32047550&form=6&db=m Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.1.3.67 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 3.1.3.67 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19932734&form=6&db=m 17betaE2 promotes cell proliferation in endometriosis by decreasing PTEN via NFkappaB-dependent pathway. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 3.1.3.67 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25421527&form=6&db=m Inducing malignant transformation of endometriosis in rats by long-term sustaining hyperestrogenemia and type II diabetes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.1.3.67 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481051&form=6&db=m Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer. causal interaction,unassigned 4,0 3.1.3.67 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10231401&form=6&db=m Molecular genetic analysis of non-astrocytic gliomas. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 3.1.3.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21960672&form=6&db=m Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder and Epilepsy. causal interaction,unassigned 4,0 3.1.3.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501575&form=6&db=m Neuroprotective and Anti-Inflammatory Roles of the Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy. ongoing research,unassigned 2,0 3.1.3.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29720545&form=6&db=m Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation. causal interaction,unassigned 4,0 3.1.3.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31658159&form=6&db=m Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32712265&form=6&db=m PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes. causal interaction,unassigned 3,0 3.1.3.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33348808&form=6&db=m Src/CK2/PTEN-Mediated GluN2B and CREB Dephosphorylations Regulate the Responsiveness to AMPA Receptor Antagonists in Chronic Epilepsy Rats. ongoing research,unassigned 2,0 3.1.3.67 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501575&form=6&db=m Neuroprotective and Anti-Inflammatory Roles of the Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy. ongoing research,unassigned 2,0 3.1.3.67 Epileptic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578218&form=6&db=m Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. causal interaction,unassigned 4,0 3.1.3.67 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995879&form=6&db=m PTEN/MMAC1 expression in esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.3.67 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20378992&form=6&db=m The adenovirus-mediated transfer of PTEN inhibits the growth of esophageal cancer cells in vitro and in vivo. causal interaction,unassigned 4,0 3.1.3.67 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22958183&form=6&db=m Inhibition of microRNA-21 increases radiosensitivity of esophageal cancer cells through phosphatase and tensin homolog deleted on chromosome 10 activation. causal interaction,unassigned 2,0 3.1.3.67 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27701465&form=6&db=m MicroRNA-20b (miR-20b) Promotes the Proliferation, Migration, Invasion, and Tumorigenicity in Esophageal Cancer Cells via the Regulation of Phosphatase and Tensin Homologue Expression. causal interaction,unassigned 4,0 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748870&form=6&db=m Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995879&form=6&db=m PTEN/MMAC1 expression in esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21104017&form=6&db=m Role of microRNA-21 and effect on PTEN in Kazakh's esophageal squamous cell carcinoma. ongoing research,unassigned 4,0 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23321166&form=6&db=m Effect of PTEN Antisense Oligonucleotide on Oesophageal Squamous Cell Carcinoma Cell Lines. ongoing research,unassigned 4,0 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25622532&form=6&db=m Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25724185&form=6&db=m PTEN gene is infrequently hypermethylated in human esophageal squamous cell carcinoma. diagnostic usage,unassigned 1,0 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26541596&form=6&db=m Association of genetic polymorphisms in PTEN and additional gene-gene interaction with risk of esophageal squamous cell carcinoma in Chinese Han population. ongoing research,unassigned 3,0 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26725440&form=6&db=m Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma. ongoing research,unassigned 3,0 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27004535&form=6&db=m Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29463194&form=6&db=m The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.1.3.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147068&form=6&db=m MiR-624-3p Promotes Esophageal Squamous Cell Carcinoma Progression via Targeting Phosphatase and Tensin Homologue. unassigned - 3.1.3.67 Exanthema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955445&form=6&db=m Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.1.3.67 Fanconi Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27819275&form=6&db=m The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. therapeutic application,unassigned 1,0 3.1.3.67 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17567478&form=6&db=m Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. ongoing research,unassigned 3,0 3.1.3.67 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26023714&form=6&db=m 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation. ongoing research,unassigned 2,0 3.1.3.67 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 3.1.3.67 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27076758&form=6&db=m Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28715695&form=6&db=m New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22619737&form=6&db=m Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders. causal interaction,unassigned 4,0 3.1.3.67 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468183&form=6&db=m Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism. causal interaction,unassigned 3,0 3.1.3.67 Fragile X Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27071790&form=6&db=m mTOR, a Potential Target to Treat Autism Spectrum Disorder. causal interaction,unassigned 2,0 3.1.3.67 Frontotemporal Lobar Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32236736&form=6&db=m PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy. causal interaction,unassigned 3,0 3.1.3.67 Ganglioneuroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24080172&form=6&db=m A familial frontotemporal dementia associated with C9orf72 repeat expansion and dysplastic gangliocytoma. causal interaction,unassigned 2,0 3.1.3.67 Ganglioneuroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26122142&form=6&db=m Exome Sequencing Reveals Germline SMAD9 Mutation That Reduces Phosphatase and Tensin Homolog Expression and Is Associated With Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas. causal interaction,unassigned 4,0 3.1.3.67 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31452757&form=6&db=m Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer. causal interaction,unassigned 3,0 3.1.3.67 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27229116&form=6&db=m The clinical correlation of phosphatase and tensin homolog on chromosome 10, phosphorylation of AKT to an activated state, and odontogenic ameloblast-associated protein in gastrointestinal stromal tumors. causal interaction,therapeutic application,unassigned 1,4,0 3.1.3.67 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27489861&form=6&db=m Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency. unassigned - 3.1.3.67 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31216739&form=6&db=m PTEN Hamartoma Tumor Syndrome: A Clinical Overview. causal interaction,unassigned 3,0 3.1.3.67 Gingival Overgrowth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23782056&form=6&db=m The role of phosphatase and tensin homolog in drug-induced gingival overgrowth. diagnostic usage,unassigned 1,0 3.1.3.67 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400560&form=6&db=m TGF-? induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma. unassigned - 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288766&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393744&form=6&db=m PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9484844&form=6&db=m PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9591629&form=6&db=m Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. causal interaction,unassigned 4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9799739&form=6&db=m Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852263&form=6&db=m A heterozygous germline mutation of the PTEN/MMAC1 gene in a patient with Cowden disease. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10564676&form=6&db=m Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10821499&form=6&db=m 10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11303623&form=6&db=m Immunocytochemical mapping of the phosphatase and tensin homolog (PTEN/MMAC1) tumor suppressor protein in human gliomas. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11550308&form=6&db=m Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12503074&form=6&db=m Chromosomal abnormalities in human glioblastomas: gain in chromosome 7p correlating with loss in chromosome 10q. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12807996&form=6&db=m Cilostazol prevents tumor necrosis factor-alpha-induced cell death by suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and activation of Akt/cyclic AMP response element-binding protein phosphorylation. therapeutic application,unassigned 1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051596&form=6&db=m Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas. causal interaction,unassigned 4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16150119&form=6&db=m Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16373498&form=6&db=m PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. causal interaction,unassigned 2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849522&form=6&db=m Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16923165&form=6&db=m Short interfering RNA-induced gene silencing is transmitted between cells from the mammalian central nervous system. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483362&form=6&db=m Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513297&form=6&db=m Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. causal interaction,unassigned 4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17960384&form=6&db=m Combination of all-trans retinoic acid and interferon-gamma upregulated p27(kip1) and down regulated CDK2 to cause cell cycle arrest leading to differentiation and apoptosis in human glioblastoma LN18 (PTEN-proficient) and U87MG (PTEN-deficient) cells. diagnostic usage,unassigned 2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18088600&form=6&db=m S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. causal interaction,unassigned 1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18215105&form=6&db=m Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18524891&form=6&db=m Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. causal interaction,unassigned 4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808964&form=6&db=m A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme. unassigned - 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21188471&form=6&db=m PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21204766&form=6&db=m Phosphatase and tensin homolog reconstruction and vascular endothelial growth factor knockdown synergistically inhibit the growth of glioblastoma. ongoing research,unassigned 1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21804599&form=6&db=m PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. causal interaction,unassigned 4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21879332&form=6&db=m Gambogenic acid-induced time- and dose-dependent growth inhibition and apoptosis involving Akt pathway inactivation in U251 glioblastoma cells. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22079609&form=6&db=m The catalytic phosphoinositol 3-kinase isoform p110? is required for glioma cell migration and invasion. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22674257&form=6&db=m STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and Transformation. causal interaction,unassigned 1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22752145&form=6&db=m Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab. ongoing research,unassigned 4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22920963&form=6&db=m Prognosis of patients with multifocal glioblastoma: a case-control study. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23110505&form=6&db=m Effects of epidermal growth factor receptor and phosphatase and tensin homologue gene expression on the inhibition of U87MG glioblastoma cell proliferation induced by protein kinase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23564811&form=6&db=m Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme. causal interaction,unassigned 3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23595342&form=6&db=m Role of PTEN in cholera toxin-induced SWO?38 glioma cell differentiation. causal interaction,ongoing research,unassigned 3,4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23798791&form=6&db=m Phosphatase and tensin homologue deleted on chromosome 10. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23838182&form=6&db=m Blockade of glioma proliferation through allosteric inhibition of JAK2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23908595&form=6&db=m A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy. causal interaction,diagnostic usage,unassigned 2,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24076665&form=6&db=m Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24704824&form=6&db=m KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway. causal interaction,unassigned 1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24721394&form=6&db=m Combined PTEN Mutation and Protein Expression Associate with Overall and Disease-Free Survival of Glioblastoma Patients. causal interaction,unassigned 2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25228449&form=6&db=m Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25682871&form=6&db=m Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25849366&form=6&db=m Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines. ongoing research,unassigned 4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26250785&form=6&db=m miR-144-3p exerts anti-tumor effects in glioblastoma by targeting c-Met. ongoing research,therapeutic application,unassigned 3,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26919320&form=6&db=m Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel. causal interaction,unassigned 2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28401302&form=6&db=m Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway. causal interaction,therapeutic application,unassigned 1,4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29038421&form=6&db=m Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29340361&form=6&db=m A curcumin-loaded polymeric micelle as a carrier of a microRNA-21 antisense-oligonucleotide for enhanced anti-tumor effects in a glioblastoma animal model. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30357833&form=6&db=m ARL4C stabilized by AKT/mTOR pathway promotes the invasion of PTEN-deficient primary human glioblastoma. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30942445&form=6&db=m Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma. unassigned - 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31760651&form=6&db=m Brain Tumors of Glial Origin. causal interaction,unassigned 4,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31776899&form=6&db=m A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma. diagnostic usage,therapeutic application,unassigned 1,1,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31787897&form=6&db=m Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma. unassigned - 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32806051&form=6&db=m Translational Nanomedicine Boosts Anti-PD1 Therapy to Eradicate Orthotopic PTEN-Negative Glioblastoma. causal interaction,ongoing research,unassigned 2,2,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33568479&form=6&db=m Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34319509&form=6&db=m Glioblastoma Therapy: Rationale for a Mesenchymal Stem Cell-based Vehicle to Carry Recombinant Viruses. causal interaction,unassigned 3,0 3.1.3.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34523696&form=6&db=m Targeting the mTOR pathway using novel ATP?competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma. causal interaction,unassigned 4,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9464544&form=6&db=m Structural and functional evidence for the presence of tumor suppressor genes on the short arm of chromosome 10 in human gliomas. therapeutic application,unassigned 1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9484844&form=6&db=m PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9490783&form=6&db=m Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671402&form=6&db=m Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681833&form=6&db=m Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692547&form=6&db=m Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9818841&form=6&db=m The functional role of tumor suppressor genes in gliomas: clues for future therapeutic strategies. ongoing research,unassigned 1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188904&form=6&db=m Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10360673&form=6&db=m Somatic mutation of PTEN in bladder carcinoma. causal interaction,unassigned 3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10589545&form=6&db=m Germline mutations of p53 but not p16/CDKN2 or PTEN/MMAC1 tumor suppressor genes predispose to gliomas. The ANOCEF Group. Association des NeuroOncologues d'Expression Française. unassigned - 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10662831&form=6&db=m A role for nuclear PTEN in neuronal differentiation. causal interaction,unassigned 3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766161&form=6&db=m Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297763&form=6&db=m PTEN/MMAC1 in malignant melanoma and its importance for tumor progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11303623&form=6&db=m Immunocytochemical mapping of the phosphatase and tensin homolog (PTEN/MMAC1) tumor suppressor protein in human gliomas. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11485247&form=6&db=m Is exon 5 of the PTEN/MMAC1 gene a prognostic marker in anaplastic glioma? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12461771&form=6&db=m PTEN regulation of neural development and CNS stem cells. diagnostic usage,unassigned 1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727853&form=6&db=m PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15184909&form=6&db=m Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. therapeutic application,unassigned 1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15679305&form=6&db=m Molecular genetic analysis of phosphatase and tensin homolog and p16 tumor suppressor genes in patients with malignant glioma. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701277&form=6&db=m Mechanisms of action of rapamycin in gliomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267832&form=6&db=m Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17159987&form=6&db=m Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18339867&form=6&db=m The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147502&form=6&db=m Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20036387&form=6&db=m Mammalian Target of Rapamycin Signaling Pathway Contributes to Glioma Progression and Patients' Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20358487&form=6&db=m The role of the PTEN gene in malignant gliomas. ongoing research,unassigned 2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20393024&form=6&db=m Mutations of PTEN gene in gliomas correlate to tumor differentiation and short-term survival rate. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530668&form=6&db=m PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21072054&form=6&db=m PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21278789&form=6&db=m Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas. unassigned - 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21617223&form=6&db=m The effect of PTEN on proliferation and drug-, and radiosensitivity in malignant glioma cells. causal interaction,unassigned 4,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22285130&form=6&db=m Characterization and response of newly developed high-grade glioma cultures to the tyrosine kinase inhibitors, erlotinib, gefitinib and imatinib. ongoing research,therapeutic application,unassigned 2,4,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23483435&form=6&db=m Management and survival rates in patients with glioma in China (2004-2010): a retrospective study from a single-institution. diagnostic usage,unassigned 2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23595342&form=6&db=m Role of PTEN in cholera toxin-induced SWO?38 glioma cell differentiation. causal interaction,ongoing research,unassigned 3,4,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24092860&form=6&db=m Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24252318&form=6&db=m The expression of PTEN in the development of mouse cochlear lateral wall. causal interaction,unassigned 2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24518612&form=6&db=m STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25228449&form=6&db=m Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25341069&form=6&db=m Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier. ongoing research,unassigned 3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25750273&form=6&db=m The Effect of Silibinin in Enhancing Toxicity of Temozolomide and Etoposide in p53 and PTEN-mutated Resistant Glioma Cell Lines. ongoing research,therapeutic application,unassigned 4,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26025112&form=6&db=m Letter regarding Xiao WZ et al. entitled "Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis". causal interaction,unassigned 3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585571&form=6&db=m Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26701969&form=6&db=m miR-21 Is Linked to Glioma Angiogenesis: A Co-Localization Study. ongoing research,unassigned 2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26919320&form=6&db=m Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel. causal interaction,unassigned 2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27073544&form=6&db=m PTEN-mRNA engineered mesenchymal stem cell-mediated cytotoxic effects on U251 glioma cells. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27347144&form=6&db=m Hypoxia regulates the expression of tissue factor pathway signaling elements in a rat glioma model. causal interaction,unassigned 3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27363339&form=6&db=m Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27366085&form=6&db=m PTEN gene mutations correlate to poor prognosis in glioma patients: a meta-analysis. diagnostic usage,ongoing research,unassigned 2,2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28621624&form=6&db=m Use of telomerase promoter mutations to mark specific molecular subsets with reciprocal clinical behavior in IDH mutant and IDH wild-type diffuse gliomas. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28712848&form=6&db=m A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK. ongoing research,unassigned 3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29286115&form=6&db=m MicroRNA-379 inhibits cell proliferation and invasion in glioma via targeting metadherin and regulating PTEN/AKT pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29718345&form=6&db=m PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872713&form=6&db=m Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event. therapeutic application,unassigned 1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30365133&form=6&db=m MicroRNA?494 promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of rapamycin pathway by phosphatase and tensin homolog expression. ongoing research,unassigned 2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31025173&form=6&db=m FGFR2-mediated phosphorylation of PTEN at tyrosine 240 contributes to the radioresistance of glioma. ongoing research,unassigned 2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31844155&form=6&db=m Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. causal interaction,unassigned 2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32099409&form=6&db=m Long Non-Coding RNA PART1 Exerts Tumor Suppressive Functions in Glioma via Sponging miR-190a-3p and Inactivation of PTEN/AKT Pathway. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32272509&form=6&db=m Dexamethasone Interferes with Autophagy and Affects Cell Survival in Irradiated Malignant Glioma Cells. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32878802&form=6&db=m Temozolomide and AZD7762 Induce Synergistic Cytotoxicity Effects on Human Glioma Cells. causal interaction,unassigned 1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33099953&form=6&db=m MiR-130b can suppress proliferation of glioma cells through targeting PTEN to regulate AKT pathway. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33293663&form=6&db=m LncRNA ANCR promotes glioma cells invasion, migration, proliferation and inhibits apoptosis via interacting with EZH2 and repressing PTEN expression. diagnostic usage,ongoing research,unassigned 2,2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33327965&form=6&db=m MiR-4310 induced by SP1 targets PTEN to promote glioma progression. ongoing research,unassigned 2,0 3.1.3.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33363203&form=6&db=m Phosphatase and Tensin Homolog Mutation in Immune Cell Infiltration and Clinicopathological Features of Low-Grade Gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33745222&form=6&db=m Altered expression of serum miR-106a, miR-19b, miR-17, and PTEN in patients with idiopathic membranous nephropathy. diagnostic usage,ongoing research,unassigned 2,1,0 3.1.3.67 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25106875&form=6&db=m PTEN upregulation may explain the development of insulin resistance and type 2 diabetes with high dose statins. ongoing research,therapeutic application,unassigned 2,4,0 3.1.3.67 Goiter http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379037&form=6&db=m Thyroid involvement in two patients with Bannayan-Riley-Ruvalcaba syndrome. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9797362&form=6&db=m Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582703&form=6&db=m PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651986&form=6&db=m Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18672141&form=6&db=m Hamartomatous polyposis syndromes. causal interaction,unassigned 1,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20962022&form=6&db=m Thyroid Nodules and Cancer in Children with PTEN Hamartoma Tumor Syndrome. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21060037&form=6&db=m Oncophenotypic review and clinical correlates of phosphatase and tensin homolog on chromosome 10 hamartoma tumor syndrome. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22184110&form=6&db=m Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. ongoing research,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22281088&form=6&db=m Clinicopathologic and Molecular Analysis of a Choroidal Pigmented Schwannoma in the Context of a PTEN Hamartoma Tumor Syndrome. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371648&form=6&db=m A case of Cowden syndrome diagnosed from multiple gastric polyposis. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22619737&form=6&db=m Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22962422&form=6&db=m PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23423780&form=6&db=m Autosomal Dominant Inherited Cowden's Disease in a Family. causal interaction,unassigned 1,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23853470&form=6&db=m Cowden syndrome- Clinico-radiological illustration of a rare case. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24136893&form=6&db=m Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria. unassigned - 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24270425&form=6&db=m AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24587660&form=6&db=m Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25170002&form=6&db=m Oral manifestations of phosphatase and tensin homolog hamartoma tumor syndrome: a report of three cases. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916396&form=6&db=m Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26208235&form=6&db=m Colonic polyps and polyposis syndromes in pediatric patients. diagnostic usage,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26488716&form=6&db=m Dermatofibrosarcoma Protuberans in a Patient With Cowden Syndrome: Revisiting the PTEN and PDGF Pathways. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26932665&form=6&db=m Pulmonary atypical carcinoid in a patient with Cowden syndrome. causal interaction,unassigned 1,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26943752&form=6&db=m Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975628&form=6&db=m Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect-PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27071790&form=6&db=m mTOR, a Potential Target to Treat Autism Spectrum Disorder. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27358095&form=6&db=m Assessment of PTEN-associated vascular malformations in a patient with Bannayan-Riley-Ruvalcaba syndrome. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27489861&form=6&db=m Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency. unassigned - 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28401059&form=6&db=m Bannayan-Riley-Ruvalcaba Syndrome in a Patient with a PTEN Mutation Identified by Chromosomal Microarray Analysis: A Case Report. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474162&form=6&db=m [Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis]. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28756566&form=6&db=m PTEN hamartoma of the soft tissue: the initial manifestation of an underlying PTEN hamartoma tumor syndrome in a 4-year-old female. diagnostic usage,unassigned 2,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28779187&form=6&db=m Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663862&form=6&db=m Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30154635&form=6&db=m Temporal Evolution and Management of Fast Flow Vascular Anomalies in PTEN Hamartoma Tumor Syndrome. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30316882&form=6&db=m Variable expressivity and novel PTEN mutations in Cowden syndrome. unassigned - 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30447426&form=6&db=m Retinal astrocytoma in a young male with PTEN hamartoma tumor syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30575166&form=6&db=m A case of follicular thyroid carcinoma associated with phosphatase and tensin homologue hamartoma tumour syndrome. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30904793&form=6&db=m Giant Cerebral Aneurysm in a Patient with Cowden Syndrome Treated with Surgical Clipping. unassigned - 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31216739&form=6&db=m PTEN Hamartoma Tumor Syndrome: A Clinical Overview. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31570378&form=6&db=m PTEN in Hereditary and Sporadic Cancer. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459922&form=6&db=m WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. causal interaction,diagnostic usage,unassigned 2,2,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32588888&form=6&db=m Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32689721&form=6&db=m Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome: A Case Report. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33887726&form=6&db=m The Clinical Spectrum of PTEN Hamartoma Tumor Syndrome: Exploring the Value of Thyroid Surveillance. unassigned - 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179044&form=6&db=m The Skin in Cowden Syndrome. causal interaction,unassigned 1,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34231499&form=6&db=m Endoscopic Findings in Patients With PTEN Hamartoma Tumor Syndrome Undergoing Surveillance. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34268892&form=6&db=m Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259288&form=6&db=m Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9354433&form=6&db=m PTEN/MMAC1 mutations in endometrial cancers. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9509273&form=6&db=m Hereditary breast cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9661881&form=6&db=m Absence of PTEN/MMAC1 germ-line mutations in sporadic Bannayan-Riley-Ruvalcaba syndrome. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671402&form=6&db=m Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9685848&form=6&db=m Germline mutations of the PTEN/MMAC1 gene in Japanese patients with Cowden disease. causal interaction,unassigned 1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765621&form=6&db=m Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9797362&form=6&db=m Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852263&form=6&db=m A heterozygous germline mutation of the PTEN/MMAC1 gene in a patient with Cowden disease. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852626&form=6&db=m A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051603&form=6&db=m Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582703&form=6&db=m PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10606430&form=6&db=m A novel germline mutation of the PTEN/MMAC1 gene in a patient with Cowden disease. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651986&form=6&db=m Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10741010&form=6&db=m Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10928124&form=6&db=m Accelerated decline of blood glucose after intravenous glucose injection in a patient with Cowden disease having a heterozygous germline mutation of the PTEN/MMAC1 gene. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14526373&form=6&db=m From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15120218&form=6&db=m Association between Cowden syndrome and Lhermitte-Duclos disease: report of two cases and review of the literature. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18460397&form=6&db=m Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome. causal interaction,unassigned 1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20600018&form=6&db=m Frequent Gastrointestinal Polyps and Colorectal Adenocarcinomas in a Prospective Series of PTEN Mutation Carriers. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21177507&form=6&db=m Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21361912&form=6&db=m Enhanced lymphocyte interferon (IFN)-? responses in a PTEN mutation-negative Cowden disease kindred. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21960672&form=6&db=m Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder and Epilepsy. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22281088&form=6&db=m Clinicopathologic and Molecular Analysis of a Choroidal Pigmented Schwannoma in the Context of a PTEN Hamartoma Tumor Syndrome. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371648&form=6&db=m A case of Cowden syndrome diagnosed from multiple gastric polyposis. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578218&form=6&db=m Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22846175&form=6&db=m SUMO, PTEN and Tumor Suppression. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22962422&form=6&db=m PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23261230&form=6&db=m Primary lung adenocarcinoma occurring in a PTEN related syndrome (Cowden's disease): routine EGFR sequencing also highlights two rare somatic mutations S768I and V769L. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23423780&form=6&db=m Autosomal Dominant Inherited Cowden's Disease in a Family. causal interaction,unassigned 1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23715080&form=6&db=m Phosphatase and tensin homolog immunohistochemical staining and clinical criteria for Cowden syndrome in patients with trichilemmoma or associated lesions. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23825907&form=6&db=m A novel PTEN gene promoter mutation and untypical Cowden syndrome. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23853470&form=6&db=m Cowden syndrome- Clinico-radiological illustration of a rare case. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24136893&form=6&db=m Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria. unassigned - 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24200851&form=6&db=m Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24270425&form=6&db=m AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24609522&form=6&db=m Mosaic partial deletion of the PTEN gene in a patient with Cowden syndrome. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24838932&form=6&db=m Genetics of endometrial cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25170002&form=6&db=m Oral manifestations of phosphatase and tensin homolog hamartoma tumor syndrome: a report of three cases. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26082588&form=6&db=m Cowden Syndrome with a Novel Germline PTEN Mutation and an Unusual Clinical Course. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26246517&form=6&db=m Cowden's syndrome with immunodeficiency. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26285813&form=6&db=m Androgen actions via androgen receptor promote PTEN inactivation induced uterine cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468640&form=6&db=m Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26488716&form=6&db=m Dermatofibrosarcoma Protuberans in a Patient With Cowden Syndrome: Revisiting the PTEN and PDGF Pathways. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26678657&form=6&db=m Neuroendocrine Tumor of the Pancreas as a Manifestation of Cowden Syndrome: A Case Report. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26932665&form=6&db=m Pulmonary atypical carcinoid in a patient with Cowden syndrome. causal interaction,unassigned 1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975628&form=6&db=m Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect-PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26992888&form=6&db=m Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27471403&form=6&db=m Genetic basis of Cowden syndrome and its implications for clinical practice and risk management. causal interaction,unassigned 2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27543776&form=6&db=m Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27932596&form=6&db=m Infantile Lhermitte-Duclos Disease Treated Successfully With Rapamycin. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28401059&form=6&db=m Bannayan-Riley-Ruvalcaba Syndrome in a Patient with a PTEN Mutation Identified by Chromosomal Microarray Analysis: A Case Report. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29282348&form=6&db=m [A Case of Cowden Syndrome Associated with Lhermitte-Duclos Disease]. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663862&form=6&db=m Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes. causal interaction,unassigned 4,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30316882&form=6&db=m Variable expressivity and novel PTEN mutations in Cowden syndrome. unassigned - 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30904793&form=6&db=m Giant Cerebral Aneurysm in a Patient with Cowden Syndrome Treated with Surgical Clipping. unassigned - 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31220904&form=6&db=m Novel PTEN mutation in Cowden syndrome: case report with late diagnosis and non-malignant course. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31570378&form=6&db=m PTEN in Hereditary and Sporadic Cancer. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31603075&form=6&db=m Intermediate uveitis in a child with phosphatase and tensin homolog gene mutation and Bannayan-Riley-Ruvalcaba syndrome. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459922&form=6&db=m WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. causal interaction,diagnostic usage,unassigned 2,2,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32588888&form=6&db=m Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32689721&form=6&db=m Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome: A Case Report. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33479580&form=6&db=m Insulin resistance and exaggerated insulin sensitivity triggered by single-gene mutations in the insulin signaling pathway. causal interaction,unassigned 3,0 3.1.3.67 Hamartoma Syndrome, Multiple http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179044&form=6&db=m The Skin in Cowden Syndrome. causal interaction,unassigned 1,0 3.1.3.67 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458098&form=6&db=m Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.3.67 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20502457&form=6&db=m The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.1.3.67 Hearing Loss, Sensorineural http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33749526&form=6&db=m PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. therapeutic application,unassigned 1,0 3.1.3.67 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30095997&form=6&db=m PTEN Inhibitor VO-OHpic Attenuates Inflammatory M1 Macrophages and Cardiac Remodeling in Doxorubicin-Induced Cardiomyopathy. causal interaction,unassigned 3,0 3.1.3.67 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31664601&form=6&db=m Nuclear miR-665 aggravates heart failure via suppressing phosphatase and tensin homolog transcription. unassigned - 3.1.3.67 Hemangioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397726&form=6&db=m Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.1.3.67 Hemangioma, Cavernous, Central Nervous System http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19061355&form=6&db=m Phosphatase and tensin homolog in cerebral cavernous malformation: a potential role in pathological angiogenesis. therapeutic application,unassigned 1,0 3.1.3.67 Hemangiosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16145208&form=6&db=m Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Hemangiosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22648906&form=6&db=m Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: A pattern distinct from other sarcomas with complex genomics. causal interaction,unassigned 3,0 3.1.3.67 Hemangiosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397726&form=6&db=m Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.1.3.67 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18337767&form=6&db=m Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. causal interaction,unassigned 3,0 3.1.3.67 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24124088&form=6&db=m Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24598081&form=6&db=m Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. causal interaction,unassigned 4,0 3.1.3.67 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24633222&form=6&db=m Hepatitis B Virus Induces Cell Proliferation via HBx-Induced microRNA-21 in Hepatocellular Carcinoma by Targeting Programmed Cell Death Protein4 (PDCD4) and Phosphatase and Tensin Homologue (PTEN). diagnostic usage,ongoing research,unassigned 1,1,0 3.1.3.67 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28715695&form=6&db=m New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31604033&form=6&db=m Hepatitis B virus-triggered PTEN/?-catenin/c-Myc signaling enhances PD-L1 expression to promote immune evasion. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25388655&form=6&db=m Hepatitis C virus NS5A drives a PTEN-PI3K/Akt feedback loop to support cell survival. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28715695&form=6&db=m New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Hepatomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17567478&form=6&db=m Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. ongoing research,unassigned 3,0 3.1.3.67 Hepatomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26820774&form=6&db=m Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice. ongoing research,unassigned 4,0 3.1.3.67 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26041445&form=6&db=m Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. unassigned - 3.1.3.67 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23845075&form=6&db=m The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23691291&form=6&db=m Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10. causal interaction,unassigned 1,0 3.1.3.67 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30262665&form=6&db=m Protein phosphatase 5 and the tumor suppressor P53 down-regulate each other's activities in mice. causal interaction,ongoing research,unassigned 3,3,0 3.1.3.67 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28855544&form=6&db=m Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway. unassigned - 3.1.3.67 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34515350&form=6&db=m Myeloid PTEN deficiency aggravates renal inflammation and fibrosis in angiotensin II-induced hypertension. ongoing research,unassigned 4,0 3.1.3.67 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31085236&form=6&db=m 5-Aza-2'-deoxycytidine, a DNA methylation inhibitor, attenuates hypoxic pulmonary hypertension via demethylation of the PTEN promoter. causal interaction,unassigned 4,0 3.1.3.67 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25416384&form=6&db=m Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26264443&form=6&db=m Phosphatase and tensin homolog deleted on chromosome 10 contributes to phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis via multiple pathways. causal interaction,ongoing research,unassigned 4,1,0 3.1.3.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763505&form=6&db=m Human Immunodeficiency Virus Type 1 Induces Lytic Cycle Replication of Kaposi's-Sarcoma-Associated Herpesvirus: Role of Ras/c-Raf/MEK1/2, PI3K/AKT, and NF-?B Signaling Pathways. unassigned - 3.1.3.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27448447&form=6&db=m MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30359076&form=6&db=m BMI1 promotes cardiac fibrosis in ischemia-induced heart failure via the PTEN-PI3K/Akt-mTOR signaling pathway. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30606984&form=6&db=m The Phosphatidylinositol 3-Kinase p110?/PTEN Signaling Pathway Is Crucial for HIV-1 Entry. ongoing research,therapeutic application,unassigned 1,1,0 3.1.3.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33044659&form=6&db=m PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.1.3.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33086544&form=6&db=m Phosphatase and Tensin Homolog (PTEN) of Japanese Flounder-Its Regulation by miRNA and Role in Autophagy, Apoptosis and Pathogen Infection. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791356&form=6&db=m Schistosoma japonicum Infection Leads to the Reprogramming of Glucose and Lipid Metabolism in the Colon of Mice. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202833&form=6&db=m Intraovarian control of early folliculogenesis. causal interaction,unassigned 1,0 3.1.3.67 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33618627&form=6&db=m The roles of microbial products in the development of colorectal cancer: a review. ongoing research,unassigned 2,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523589&form=6&db=m Increase of PTEN gene expression in insulin resistance. therapeutic application,unassigned 1,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17373630&form=6&db=m Role of tumor suppressor PTEN in tumor necrosis factor alpha-induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells. ongoing research,unassigned 4,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18166358&form=6&db=m PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism. causal interaction,unassigned 1,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19491300&form=6&db=m Peroxisome proliferator-activated receptor-gamma agonist improves skeletal muscle insulin signaling in the pregestational intrauterine growth-restricted rat offspring. unassigned - 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21465524&form=6&db=m Metformin sensitizes insulin signaling through AMPK-mediated pten down-regulation in preadipocyte 3T3-L1 cells. ongoing research,therapeutic application,unassigned 2,2,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22956257&form=6&db=m MiRNA-21 Reverses High Glucose and High Insulin Induced Insulin Resistance in 3T3-L1 Adipocytes through Targeting Phosphatase and Tensin Homologue. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23845075&form=6&db=m The influence of diabetes in the pathogenesis and the clinical course of hepatocellular carcinoma: recent findings and new perspectives. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24404172&form=6&db=m Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in Wistar rats. unassigned - 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25659997&form=6&db=m Increased Plasma Levels of FABP4 and PTEN Is Associated with More Severe Insulin Resistance in Women with Gestational Diabetes Mellitus. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25777795&form=6&db=m Sex differences in skeletal muscle phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels: a cross-sectional study. therapeutic application,unassigned 1,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26384875&form=6&db=m IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes. causal interaction,unassigned 4,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27068875&form=6&db=m A common variation of the PTEN gene is associated with peripheral insulin resistance. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27149630&form=6&db=m Insulin Signaling in Insulin Resistance States and Cancer: A Modeling Analysis. therapeutic application,unassigned 3,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28024145&form=6&db=m Calorie restriction prevents the development of insulin resistance and impaired lipid metabolism in gestational diabetes offspring. causal interaction,unassigned 1,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28647369&form=6&db=m Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes. ongoing research,unassigned 2,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29068796&form=6&db=m Protein phosphatases and podocyte function. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29154111&form=6&db=m PTEN expression and its association with glucose control and calorie supplementation in critically ill patients. ongoing research,therapeutic application,unassigned 3,2,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30148676&form=6&db=m GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues. ongoing research,unassigned 2,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30359674&form=6&db=m Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon. diagnostic usage,ongoing research,unassigned 2,2,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30542438&form=6&db=m PTEN in propofol-induced insulin resistance in mouse primary hepatocytes. causal interaction,unassigned 1,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30819264&form=6&db=m PTEN influences insulin and lipid metabolism in bovine hepatocytes in vitro. unassigned - 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31824561&form=6&db=m Whole Transcriptome Analysis of Obese Adipose Tissue Suggests u001kfc.1 as a Potential Regulator to Glucose Homeostasis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32581820&form=6&db=m Icariin Attenuates Amyloid-? (A?)-Induced Neuronal Insulin Resistance Through PTEN Downregulation. unassigned - 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33293478&form=6&db=m miR-18a increases insulin sensitivity by inhibiting PTEN. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34235122&form=6&db=m Insulin sensitization causes accelerated sinus nodal dysfunction through autophagic dysregulation in hypertensive mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.1.3.67 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917848&form=6&db=m Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10662831&form=6&db=m A role for nuclear PTEN in neuronal differentiation. causal interaction,unassigned 3,0 3.1.3.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27553586&form=6&db=m Multicentric Glioma Develops via a Mutant IDH1-Independent Pathway: Immunohistochemical Study of Multicentric Glioma. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18672141&form=6&db=m Hamartomatous polyposis syndromes. causal interaction,unassigned 1,0 3.1.3.67 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29845190&form=6&db=m Dysregulation of microRNA?23b?3p contributes to the development of intracranial aneurysms by targeting phosphatase and tensin homolog. unassigned - 3.1.3.67 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34240392&form=6&db=m Mesenchymal stem cells-derived exosomes modulate vascular endothelial injury via miR-144-5p/PTEN in intracranial aneurysm. causal interaction,unassigned 3,0 3.1.3.67 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20360540&form=6&db=m Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke. causal interaction,unassigned 4,0 3.1.3.67 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24312220&form=6&db=m Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.3.67 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24875179&form=6&db=m PTEN degradation after ischemic stroke: a double-edged sword. causal interaction,unassigned 3,0 3.1.3.67 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33062677&form=6&db=m Wubeizi Ointment Suppresses Keloid Formation through Modulation of the mTOR Pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692547&form=6&db=m Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.1.3.67 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32355326&form=6&db=m The diverse roles of SPOP in prostate cancer and kidney cancer. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Klippel-Trenaunay-Weber Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30844349&form=6&db=m Congenital Limb Overgrowth Syndromes Associated with Vascular Anomalies. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25892179&form=6&db=m DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. causal interaction,unassigned 4,0 3.1.3.67 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18000229&form=6&db=m Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19464003&form=6&db=m Changes related to phosphatidylinositol 3-kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3alpha and cyclin D2 in the pathophysiology. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12569572&form=6&db=m PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21837670&form=6&db=m The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706759&form=6&db=m Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19563023&form=6&db=m [The role of PTEN-FAK signaling pathway in metastasis and invasive ability of leukemia cells] causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20008787&form=6&db=m Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21212363&form=6&db=m Suppression of leukemia development caused by PTEN loss. ongoing research,unassigned 1,0 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22829096&form=6&db=m Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24124088&form=6&db=m Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25201756&form=6&db=m Rictor/mammalian target of rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3. ongoing research,unassigned 2,0 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29567770&form=6&db=m Fit ?? T-Cell Receptor suppresses leukemogenesis of Pten-deficient thymocytes. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30841886&form=6&db=m Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 3.1.3.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33708847&form=6&db=m DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.3.67 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23013295&form=6&db=m Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.1.3.67 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23134359&form=6&db=m The phosphoinositide 3-kinase pathway in chronic lymphocytic leukemia: evidence for phosphatase and tensin homolog deletion on chromosome 10 deregulation. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19563023&form=6&db=m [The role of PTEN-FAK signaling pathway in metastasis and invasive ability of leukemia cells] causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21143615&form=6&db=m BCR-ABL translocation in a dog with chronic monocytic leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1 3.1.3.67 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33941772&form=6&db=m Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.3.67 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706759&form=6&db=m Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15297415&form=6&db=m Elevated S-phase kinase-associated protein 2 protein expression in acute myelogenous leukemia: its association with constitutive phosphorylation of phosphatase and tensin homologue protein and poor prognosis. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.3.67 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26170984&form=6&db=m Prognostic value of the expression of phosphatase and tensin homolog and CD44 in elderly patients with refractory acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.1.3.67 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29397829&form=6&db=m [Expression and Significance of PTEN and BCL-2 in Acute Myeloid Leukemia]. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Leukemia-Lymphoma, Adult T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33128318&form=6&db=m Pathophysiological significance of N-myc downstream-regulated gene 2 in cancer development through protein phosphatase 2A phosphorylation regulation. ongoing research,unassigned 1,0 3.1.3.67 Lipoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29568880&form=6&db=m Simvastatin induces apoptosis in PTEN?haploinsufficient lipoma cells. ongoing research,unassigned 4,0 3.1.3.67 Lipoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32579864&form=6&db=m A new human adipocyte model with PTEN haploinsufficiency. ongoing research,unassigned 3,0 3.1.3.67 Lipomatosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26943752&form=6&db=m Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity. causal interaction,unassigned 4,0 3.1.3.67 Liposarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27702598&form=6&db=m Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. causal interaction,unassigned 4,0 3.1.3.67 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17567478&form=6&db=m Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice. ongoing research,unassigned 3,0 3.1.3.67 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24138392&form=6&db=m Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis. unassigned - 3.1.3.67 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33481270&form=6&db=m miR-21-regulated M2 polarization of macrophage is involved in arsenicosis-induced hepatic fibrosis through the activation of hepatic stellate cells. unassigned - 3.1.3.67 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23390000&form=6&db=m Identification of microRNAs specifically expressed in hepatitis C virus-associated hepatocellular carcinoma. causal interaction,unassigned 1,0 3.1.3.67 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27076758&form=6&db=m Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 3.1.3.67 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28715695&form=6&db=m New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19082655&form=6&db=m Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26166433&form=6&db=m A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration. ongoing research,unassigned 1,0 3.1.3.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26589417&form=6&db=m Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26823866&form=6&db=m Association of PTEN gene polymorphisms with liver cancer risk. unassigned - 3.1.3.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27173355&form=6&db=m Effect of overexpression of PTEN on apoptosis of liver cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29400692&form=6&db=m Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer. unassigned - 3.1.3.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29807978&form=6&db=m Suppression of miR-21 Expression Inhibits Cell Proliferation and Migration of Liver Cancer Cells by Targeting Phosphatase and Tensin Homolog (PTEN). ongoing research,unassigned 3,0 3.1.3.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30405802&form=6&db=m Association of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.3.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34505419&form=6&db=m Oncogenic Activity of Solute Carrier Family 45 Member 2 and Alpha-Methylacyl-Coenzyme A Racemase Gene Fusion Is Mediated by Mitogen-Activated Protein Kinase. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Long QT Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21097842&form=6&db=m Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome. causal interaction,unassigned 2,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458098&form=6&db=m Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9467947&form=6&db=m Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. ongoing research,unassigned 3,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696041&form=6&db=m PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9794233&form=6&db=m Mutation analysis of the PTEN/MMAC1 gene in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10470842&form=6&db=m Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16638863&form=6&db=m Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17314339&form=6&db=m DNA synthesis and repair genes RRM1 and ERCC1 in lung cancer. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281487&form=6&db=m Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18374229&form=6&db=m Combination of PTEN and gamma-ionizing radiation enhances cell death and G(2)/M arrest through regulation of AKT activity and p21 induction in non-small-cell lung cancer cells. ongoing research,therapeutic application,unassigned 3,3,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661141&form=6&db=m Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN. diagnostic usage,ongoing research,unassigned 2,4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20018398&form=6&db=m PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20211060&form=6&db=m [Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines] diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23592446&form=6&db=m mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25861627&form=6&db=m PTEN plays an important role in thrombin-mediated lung cancer cell functions. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26166648&form=6&db=m High levels of phosphatase and tensin homolog expression predict favorable prognosis in patients with non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27095949&form=6&db=m Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers. causal interaction,ongoing research,unassigned 2,1,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259304&form=6&db=m High levels of Phosphatase and Tensin Homolog Expression Predict Favorable Prognosis in Patients with Non-small Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333149&form=6&db=m PTEN expression is associated with the outcome of lung cancer: evidence from a meta-analysis. diagnostic usage,ongoing research,unassigned 4,2,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27385992&form=6&db=m Small activating ribonucleic acid reverses tyrosine kinase inhibitor resistance in epidermal growth factor receptor-mutant lung cancer by increasing the expression of phosphatase and tensin homolog. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506936&form=6&db=m PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature. causal interaction,unassigned 4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27769862&form=6&db=m miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog. unassigned - 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27980214&form=6&db=m The ISG15-specific protease USP18 regulates stability of PTEN. ongoing research,unassigned 4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263037&form=6&db=m Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714370&form=6&db=m Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28786540&form=6&db=m Concurrent epidermal growth factor receptor T790M secondary mutation and epithelial-mesenchymal transition in a lung adenocarcinoma patient with EGFR-TKI drug resistance. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28872922&form=6&db=m miR-1297 Promotes Cell Proliferation of Non-Small Cell Lung Cancer Cells: Involving in PTEN/Akt/Skp2 Signaling Pathway. causal interaction,unassigned 1,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29271375&form=6&db=m Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29340020&form=6&db=m EYA2 promotes lung cancer cell proliferation by downregulating the expression of PTEN. causal interaction,unassigned 1,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29578164&form=6&db=m Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31074594&form=6&db=m MicroRNA-4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non-small cell lung cancer. causal interaction,unassigned 4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423258&form=6&db=m SHCBP1 regulates apoptosis in lung cancer cells through phosphatase and tensin homolog. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32436415&form=6&db=m Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy. ongoing research,unassigned 4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32452893&form=6&db=m Suberoylanilide hydroxamic acid overcomes erlotinib-acquired resistance via phosphatase and tensin homolog deleted on chromosome 10-mediated apoptosis in non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32626930&form=6&db=m The long non?coding RNA CASC7 inhibits growth and invasion of non?small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR?92a. causal interaction,unassigned 1,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33467964&form=6&db=m Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression. ongoing research,unassigned 2,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33821441&form=6&db=m Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells. causal interaction,unassigned 3,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33904341&form=6&db=m The influence of circular RNAs on autophagy and disease progression. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34416231&form=6&db=m The deubiquitinase USP10 restores PTEN activity and inhibits non-small cell lung cancer cell proliferation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 3.1.3.67 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32506314&form=6&db=m Systemic lupus erythematosus in a girl with PTEN variant and transaldolase deficiency: a novel phenotype. causal interaction,unassigned 4,0 3.1.3.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20502457&form=6&db=m The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.1.3.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20825972&form=6&db=m Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.1.3.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22240798&form=6&db=m Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.1.3.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870211&form=6&db=m Molecular determinants for lymph node metastasis in clinically early-stage endometrial cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28941804&form=6&db=m MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29463194&form=6&db=m The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.1.3.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29578164&form=6&db=m Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9882102&form=6&db=m Deletions in the long arm of chromosome 10 in lymphomas with t(14;18): a pathogenetic role of the tumor supressor genes PTEN/MMAC1 and MXI1? causal interaction,unassigned 3,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18551192&form=6&db=m Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. therapeutic application,unassigned 1,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20354178&form=6&db=m The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of rapamycin signaling. unassigned - 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426775&form=6&db=m [Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.] diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28723738&form=6&db=m Phosphatase and tensin homolog (PTEN) is down-regulated in human NK/T-cell lymphoma and corrects with clinical outcomes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943948&form=6&db=m Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice. causal interaction,unassigned 1,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115608&form=6&db=m MicroRNA?27a promotes tumorigenesis via targeting AKT in triple negative breast cancer. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29328455&form=6&db=m Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma. therapeutic application,unassigned 1,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29436653&form=6&db=m Upregulation of phosphatase and tensin homolog is essential for the effect of 4-aminopyridine on A549/CDDP cells. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30015974&form=6&db=m Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation?dependent apoptosis. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30296359&form=6&db=m MCL1 Gene Silencing Promotes Senescence and Apoptosis of Glioma Cells via Inhibition of the PI3K/Akt Signaling Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30816511&form=6&db=m Tripartite motif?containing 11 regulates the proliferation and apoptosis of breast cancer cells. causal interaction,therapeutic application,unassigned 3,2,0 3.1.3.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32004387&form=6&db=m Evaluation of the PIK3 pathway in peripheral T-cell lymphoma and NK/T-cell lymphoma. therapeutic application,unassigned 3,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426775&form=6&db=m [Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.] diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23336417&form=6&db=m [The expression and meanning of Skp2, p27, PTEN proteins in non-Hodgkin B-cell lymphoma of ocular adnexa]. ongoing research,unassigned 1,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25867342&form=6&db=m Effect of TIEG1 on apoptosis and expression of Bcl-2/Bax and Pten in leukemic cell lines. ongoing research,unassigned 4,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27186313&form=6&db=m microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. causal interaction,unassigned 2,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28192480&form=6&db=m mTOR activity in AIDS-related diffuse large B-cell lymphoma. ongoing research,unassigned 1,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28476823&form=6&db=m Prediction of Relapse After Therapy Withdrawal in Women with Endometrial Hyperplasia: A Long-term Follow-up Study. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115608&form=6&db=m MicroRNA?27a promotes tumorigenesis via targeting AKT in triple negative breast cancer. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399358&form=6&db=m Predictive biomarkers for combined chemotherapy with 5-fluorouracil and cisplatin in oro- and hypopharyngeal cancers. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30013659&form=6&db=m miRNA-29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3? and Wnt/?-catenin signaling pathways. ongoing research,unassigned 3,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30296359&form=6&db=m MCL1 Gene Silencing Promotes Senescence and Apoptosis of Glioma Cells via Inhibition of the PI3K/Akt Signaling Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30679990&form=6&db=m MicroRNA-146b induces the PI3K/Akt/NF-?B signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. diagnostic usage,therapeutic application,unassigned 3,3,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30845295&form=6&db=m Clinical, morphological and immunohistochemical survey in different types of endometriosis. causal interaction,unassigned 4,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30861992&form=6&db=m Preventive Effect of Lactobacillus fermentum CQPC08 on 4-Nitroquineline-1-Oxide Induced Tongue Cancer in C57BL/6 Mice. causal interaction,unassigned 3,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30985693&form=6&db=m MicroRNA-related transcription factor regulatory networks in human colorectal cancer. causal interaction,unassigned 1,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393046&form=6&db=m The expression of microRNAs and exposure to environmental contaminants related to human health: a review. ongoing research,unassigned 2,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33724154&form=6&db=m Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34046322&form=6&db=m Cytotoxic effects of hydroalcoholic extract of Cuscuta chinensis on PC3 and MCF7 cancer cell lines. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28192480&form=6&db=m mTOR activity in AIDS-related diffuse large B-cell lymphoma. ongoing research,unassigned 1,0 3.1.3.67 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9697884&form=6&db=m Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.1.3.67 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14653075&form=6&db=m [Expression of PTEN and p27 proteins in non-Hodgkin's lymphoma] ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23774695&form=6&db=m Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi. diagnostic usage,unassigned 3,0 3.1.3.67 Malformations of Cortical Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26992888&form=6&db=m Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons. causal interaction,unassigned 4,0 3.1.3.67 Malformations of Cortical Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27543776&form=6&db=m Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter. causal interaction,unassigned 4,0 3.1.3.67 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24154871&form=6&db=m PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition. causal interaction,therapeutic application,unassigned 3,2,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10662831&form=6&db=m A role for nuclear PTEN in neuronal differentiation. causal interaction,unassigned 3,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21960672&form=6&db=m Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder and Epilepsy. causal interaction,unassigned 4,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578218&form=6&db=m Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. causal interaction,unassigned 4,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23361946&form=6&db=m Macrocephaly as a clinical indicator of genetic subtypes in autism. causal interaction,unassigned 2,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25561290&form=6&db=m Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26992888&form=6&db=m Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons. causal interaction,unassigned 4,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29720545&form=6&db=m Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation. causal interaction,unassigned 4,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31594918&form=6&db=m Neurobehavioral phenotype of autism spectrum disorder associated with germline heterozygous mutations in PTEN. causal interaction,unassigned 4,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31636454&form=6&db=m Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. unassigned - 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31639285&form=6&db=m Mutations in the sonic hedgehog pathway cause macrocephaly-associated conditions due to crosstalk to the PI3K/AKT/mTOR pathway. causal interaction,unassigned 4,0 3.1.3.67 Megalencephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34268892&form=6&db=m Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly. causal interaction,unassigned 3,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9689095&form=6&db=m In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692547&form=6&db=m Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340391&form=6&db=m PTEN/MMAC1 mutations in hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651986&form=6&db=m Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766161&form=6&db=m Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297763&form=6&db=m PTEN/MMAC1 in malignant melanoma and its importance for tumor progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11323215&form=6&db=m Recent advances in melanoma research. causal interaction,unassigned 4,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12454773&form=6&db=m PTEN/MMAC1 expression in melanoma resection specimens. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782594&form=6&db=m Loss of PTEN promotes tumor development in malignant melanoma. causal interaction,unassigned 4,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789288&form=6&db=m PTEN signaling pathways in melanoma. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576666&form=6&db=m PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma. causal interaction,unassigned 4,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009714&form=6&db=m Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16033830&form=6&db=m PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation. causal interaction,unassigned 4,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16146807&form=6&db=m Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16417231&form=6&db=m Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818626&form=6&db=m Epigenetic silencing of the PTEN gene in melanoma. causal interaction,unassigned 3,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17907961&form=6&db=m Focal adhesion kinase: a promising target for anticancer therapy. therapeutic application,unassigned 1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20956280&form=6&db=m Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22511720&form=6&db=m Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis. causal interaction,unassigned 2,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23564767&form=6&db=m PTEN regulates sensitivity of melanoma cells to RO4929097, the ?-secretase inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23662813&form=6&db=m E- to N-cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24141770&form=6&db=m PTEN functions as a melanoma tumor suppressor by promoting host immune response. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830350&form=6&db=m Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy. therapeutic application,unassigned 4,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25897829&form=6&db=m PRL-3 Promotes the Malignant Progression of Melanoma via Triggering Dephosphorylation and Cytoplasmic Localization of NHERF1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26854490&form=6&db=m Promoter Methylation of PTEN Is a Significant Prognostic Factor in Melanoma Survival. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27718503&form=6&db=m Immunohistochemical analysis of T-type calcium channels in acquired melanocytic naevi and melanoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28092677&form=6&db=m WNT/?-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28463229&form=6&db=m Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512776&form=6&db=m miR?367 enhances the proliferation and invasion of cutaneous malignant melanoma by regulating phosphatase and tensin homolog expression. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32512654&form=6&db=m Comprehensive Analysis of PTEN in Primary Cutaneous Melanoma. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32782575&form=6&db=m Shank-associated RH domain interactor signaling in tumorigenesis. unassigned - 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33094056&form=6&db=m A Rare Case of Atypical Pleomorphic Neoplasm of Pineal Region in a Child: A Case Report. diagnostic usage,unassigned 3,0 3.1.3.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33643925&form=6&db=m iNOS Associates With Poor Survival in Melanoma: A Role for Nitric Oxide in the PI3K-AKT Pathway Stimulation and PTEN S-Nitrosylation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.1.3.67 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31658159&form=6&db=m Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31887465&form=6&db=m Low Expression of Phosphatase and Tensin Homolog and High Expression of Ki-67 as Risk Factors of Prognosis in Cranial Meningiomas. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0 3.1.3.67 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9794233&form=6&db=m Mutation analysis of the PTEN/MMAC1 gene in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.1.3.67 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605070&form=6&db=m Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605070&form=6&db=m Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27986563&form=6&db=m Role and mechanism of PTEN in adiponectin-induced osteogenesis in human bone marrow mesenchymal stem cells. causal interaction,unassigned 3,0 3.1.3.67 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27121999&form=6&db=m PTEN inhibition preserves trigeminal nucleus caudalis neuron activation through tyrosine phosphorylation of the NR2B subunit at Tyr1472 of the NMDA receptor in a rat model of recurrent migraine. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28791398&form=6&db=m PI3K/AKT signaling pathway activation in a rat model of migraine. unassigned - 3.1.3.67 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26988681&form=6&db=m [Phosphatase and tensin homolog deleted on chromosome ten/phosphatidyl Inositol 3-kinase/vascular endothelial growth factor signaling pathway changes in the rabbit Kawasaki disease model]. ongoing research,unassigned 1,0 3.1.3.67 Multiple Endocrine Neoplasia Type 2a http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23556055&form=6&db=m Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome. causal interaction,unassigned 4,0 3.1.3.67 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22149168&form=6&db=m Expression levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and focal adhesion kinase in patients with multiple myeloma and their relationship to clinical stage and extramedullary infiltration. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22220917&form=6&db=m The role of phosphatase and tensin homolog deleted on chromosome 10 and focal adhesion kinase in aggressive multiple myeloma. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27919956&form=6&db=m Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.1.3.67 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20153750&form=6&db=m Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice. ongoing research,therapeutic application,unassigned 3,4,0 3.1.3.67 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17651088&form=6&db=m Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. causal interaction,unassigned 3,0 3.1.3.67 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30478082&form=6&db=m Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation. ongoing research,unassigned 4,0 3.1.3.67 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33053428&form=6&db=m Polymeric nanoparticles functionalized with muscle-homing peptides for targeted delivery of phosphatase and tensin homolog inhibitor to skeletal muscle. therapeutic application,unassigned 3,0 3.1.3.67 Myeloproliferative Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25201756&form=6&db=m Rictor/mammalian target of rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3. ongoing research,unassigned 2,0 3.1.3.67 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147652&form=6&db=m MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. ongoing research,unassigned 2,0 3.1.3.67 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26973267&form=6&db=m MicroRNA-214 Inhibits Left Ventricular Remodeling in an Acute Myocardial Infarction Rat Model by Suppressing Cellular Apoptosis via the Phosphatase and Tensin Homolog (PTEN). ongoing research,therapeutic application,unassigned 3,2,0 3.1.3.67 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27708252&form=6&db=m Effects of mir-21 on Cardiac Microvascular Endothelial Cells After Acute Myocardial Infarction in Rats: Role of Phosphatase and Tensin Homolog (PTEN)/Vascular Endothelial Growth Factor (VEGF) Signal Pathway. ongoing research,unassigned 4,0 3.1.3.67 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33253002&form=6&db=m Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29658565&form=6&db=m (?)?Epicatechin protects against myocardial ischemia?induced cardiac injury via activation of the PTEN/PI3K/AKT pathway. unassigned - 3.1.3.67 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31868827&form=6&db=m Inhibition of TRPA1 Promotes Cardiac Repair in Mice After Myocardial Infarction. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24604064&form=6&db=m Aberrant CpG island methylation of PTEN is an early event in nasopharyngeal carcinoma and a potential diagnostic biomarker. causal interaction,unassigned 4,0 3.1.3.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27412938&form=6&db=m [Relationship between PTEN mutations and protein kinase B phosphorylation caused by insulin or recombinant human epidermal growth factor stimulation]. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27840403&form=6&db=m MicroRNA-152 Targets Phosphatase and Tensin Homolog to Inhibit Apoptosis and Promote Cell Migration of Nasopharyngeal Carcinoma Cells. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30834525&form=6&db=m miR-144-3p facilitates nasopharyngeal carcinoma via crosstalk with PTEN. ongoing research,unassigned 2,0 3.1.3.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32281513&form=6&db=m Inhibition of PTEN Gene Expression by Small Interfering RNA on PI3K/Akt/FoxO3a Signaling Pathway in Human Nasopharyngeal Carcinoma. ongoing research,unassigned 3,0 3.1.3.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33601482&form=6&db=m [CD44 regulates biological behavior and Ras signaling pathway in nasopharyngeal carcinoma stem cells]. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.3.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34398299&form=6&db=m Dynamic contrast-enhanced MRI predicts PTEN protein expression which can function as a prognostic measure of progression-free survival in NPC patients. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9829719&form=6&db=m Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10470842&form=6&db=m Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499615&form=6&db=m Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766161&form=6&db=m Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297763&form=6&db=m PTEN/MMAC1 in malignant melanoma and its importance for tumor progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12719974&form=6&db=m Epithelial-myoepithelial carcinoma of the parotid gland-evidence of contrasting DNA patterns in two different histological parts. unassigned - 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15009714&form=6&db=m Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17347137&form=6&db=m The role of PTEN in prostate cancer cell tropism to the bone micro-environment. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19563023&form=6&db=m [The role of PTEN-FAK signaling pathway in metastasis and invasive ability of leukemia cells] causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917848&form=6&db=m Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20502457&form=6&db=m The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20825972&form=6&db=m Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21520171&form=6&db=m Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance. causal interaction,unassigned 4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22240798&form=6&db=m Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22494966&form=6&db=m Mesenchymal stem cell signaling in cancer progression. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23205120&form=6&db=m Immunohistochemical expression of mTOR negatively correlates with PTEN expression in gastric carcinoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23273076&form=6&db=m High levels of phosphatase and tensin homolog expression are associated with tumor progression, tumor recurrence, and systemic metastases in pT1 urothelial carcinoma of the bladder: a tissue microarray study of 156 patients treated by transurethral resection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23287991&form=6&db=m Dp44mT targets the AKT, TGF-? and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells. unassigned - 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486402&form=6&db=m PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25499255&form=6&db=m Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. causal interaction,unassigned 3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25963289&form=6&db=m Negative expression of PTEN identifies high risk for lymphatic-related metastasis in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26715198&form=6&db=m KRAS mutation in lung metastases from colorectal cancer: prognostic implications. ongoing research,unassigned 2,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870211&form=6&db=m Molecular determinants for lymph node metastasis in clinically early-stage endometrial cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27113763&form=6&db=m miR-10b expression in breast cancer stem cells supports self-renewal through negative PTEN regulation and sustained AKT activation. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465552&form=6&db=m PTP1B promotes aggressiveness of breast cancer cells by regulating PTEN but not EMT. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27466505&form=6&db=m PTEN Insufficiency Increases Breast Cancer Cell Metastasis In Vitro and In Vivo in a Xenograft Zebrafish Model. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27572739&form=6&db=m PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN. causal interaction,unassigned 4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590223&form=6&db=m Gene heterogeneity in metastasis of colorectal cancer to the lung. causal interaction,diagnostic usage,unassigned 3,4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28534966&form=6&db=m MicroRNA-92a promotes epithelial-mesenchymal transition through activation of PTEN/PI3K/AKT signaling pathway in non-small cell lung cancer metastasis. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28606050&form=6&db=m Insights into the targeting potential of thymoquinone for therapeutic intervention against triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804548&form=6&db=m Overexpression of PTEN suppresses non-small-cell lung carcinoma metastasis through inhibition of integrin ?V?6 signaling. causal interaction,unassigned 4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28941804&form=6&db=m MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29160937&form=6&db=m MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A. unassigned - 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29283497&form=6&db=m Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level. causal interaction,unassigned 4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29463194&form=6&db=m The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29556614&form=6&db=m The tyrosine kinase inhibitors effects on metastatic tumor graft in the chick chorioallantoic membrane assay. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29578164&form=6&db=m Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021351&form=6&db=m microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma. unassigned - 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30226608&form=6&db=m Generation of PTEN?knockout (?/?) murine prostate cancer cells using the CRISPR/Cas9 system and comprehensive gene expression profiling. causal interaction,unassigned 4,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31115514&form=6&db=m Long non?coding RNA FER1L4 inhibits cell proliferation and metastasis through regulation of the PI3K/AKT signaling pathway in lung cancer cells. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31564201&form=6&db=m Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31621072&form=6&db=m miR-298 plays a pivotal role in colon cancer invasiveness by targeting PTEN. causal interaction,unassigned 1,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33121268&form=6&db=m LncRNA GAS5 Suppresses the Proliferation and Invasion of Osteosarcoma Cells via the miR-23a-3p/PTEN/PI3K/AKT Pathway. unassigned - 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33467964&form=6&db=m Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression. ongoing research,unassigned 2,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614485&form=6&db=m Identification of a Glycolysis-Related LncRNA Signature to Predict Survival in Diffuse Glioma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33670518&form=6&db=m Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers. causal interaction,unassigned 3,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149905&form=6&db=m Next-generation sequencing-based identification of EGFR and NOTCH2 complementary mutations in non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34370147&form=6&db=m Synergistic effects of Rapamycin and Fluorouracil to treat a gastric tumor in a PTEN conditional deletion mouse model. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187108&form=6&db=m TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259288&form=6&db=m Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288766&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9354433&form=6&db=m PTEN/MMAC1 mutations in endometrial cancers. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9367992&form=6&db=m A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9371490&form=6&db=m Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393744&form=6&db=m PTEN/MMAC1 mutations and EGFR amplification in glioblastomas. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9439675&form=6&db=m Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9443392&form=6&db=m Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458098&form=6&db=m Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9467947&form=6&db=m Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9484844&form=6&db=m PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9490783&form=6&db=m Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9510470&form=6&db=m Infrequent mutations in the PTEN/MMAC1 gene among primary breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9514946&form=6&db=m Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9560261&form=6&db=m Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9591629&form=6&db=m Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593664&form=6&db=m The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9605750&form=6&db=m Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9616126&form=6&db=m Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9625175&form=6&db=m Identification of a pseudogene that can masquerade as a mutant allele of the PTEN/MMAC1 tumor suppressor gene. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9625810&form=6&db=m Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9643506&form=6&db=m The molecular genetics of central nervous system tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9661880&form=6&db=m Frequent inactivation of PTEN in prostate cancer cell lines and xenografts. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671402&form=6&db=m Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681833&form=6&db=m Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9689095&form=6&db=m In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692547&form=6&db=m Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696041&form=6&db=m PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9697884&form=6&db=m Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765621&form=6&db=m Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9778300&form=6&db=m Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9788441&form=6&db=m PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9794233&form=6&db=m Mutation analysis of the PTEN/MMAC1 gene in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9797362&form=6&db=m Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9799739&form=6&db=m Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9818841&form=6&db=m The functional role of tumor suppressor genes in gliomas: clues for future therapeutic strategies. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9829719&form=6&db=m Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852263&form=6&db=m A heterozygous germline mutation of the PTEN/MMAC1 gene in a patient with Cowden disease. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9852626&form=6&db=m A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9861013&form=6&db=m The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9865719&form=6&db=m The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9882102&form=6&db=m Deletions in the long arm of chromosome 10 in lymphomas with t(14;18): a pathogenetic role of the tumor supressor genes PTEN/MMAC1 and MXI1? causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927060&form=6&db=m Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9990064&form=6&db=m Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051603&form=6&db=m Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10193626&form=6&db=m Lhermitte-Duclos disease as a component of Cowden's syndrome. Case report and review of the literature. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10202180&form=6&db=m Are aberrant transcripts of FHIT, TSG101, and PTEN/MMAC1 oncogenesis related? causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10208437&form=6&db=m Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10231401&form=6&db=m Molecular genetic analysis of non-astrocytic gliomas. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10340391&form=6&db=m PTEN/MMAC1 mutations in hepatocellular carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10360673&form=6&db=m Somatic mutation of PTEN in bladder carcinoma. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10363579&form=6&db=m PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10404099&form=6&db=m Loss of heterozygosity at 10q in tumors of the upper respiratory tract is associated with poor prognosis. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10434955&form=6&db=m Chromosomal basis of adenocarcinoma of the prostate. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10469123&form=6&db=m PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10470842&form=6&db=m Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10472782&form=6&db=m Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485448&form=6&db=m Alterations of the PPP1R3 gene in human cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10492641&form=6&db=m Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract. causal interaction,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10499615&form=6&db=m Genetic alterations of the tumor suppressor gene PTEN/MMAC1 in human brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10503872&form=6&db=m Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10564676&form=6&db=m Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10581415&form=6&db=m Regulation of PTEN expression in neuronal apoptosis. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582703&form=6&db=m PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10589545&form=6&db=m Germline mutations of p53 but not p16/CDKN2 or PTEN/MMAC1 tumor suppressor genes predispose to gliomas. The ANOCEF Group. Association des NeuroOncologues d'Expression Française. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10598804&form=6&db=m A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10601551&form=6&db=m Aberrant transcripts of FHIT, TSG101 and PTEN/MMAC1 genes in normal peripheral mononuclear cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10628321&form=6&db=m Somatic mutation and homozygous deletion of PTEN/MMAC1 gene of 10q23 in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10637069&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651986&form=6&db=m Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657903&form=6&db=m Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10705874&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706759&form=6&db=m Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10724333&form=6&db=m Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10741010&form=6&db=m Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748157&form=6&db=m Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10748870&form=6&db=m Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766161&form=6&db=m Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778994&form=6&db=m Correspondence re: W.M. Lin et al., loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. Clin. Cancer Res., 4: 2577-2583, 1998. diagnostic usage,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10821499&form=6&db=m 10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10928124&form=6&db=m Accelerated decline of blood glucose after intravenous glucose injection in a patient with Cowden disease having a heterozygous germline mutation of the PTEN/MMAC1 gene. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10995879&form=6&db=m PTEN/MMAC1 expression in esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093061&form=6&db=m Molecular genetic defects in endometriosis. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11120338&form=6&db=m Identification of a novel PTEN intronic deletion in Li-Fraumeni syndrome and its effect on RNA processing. causal interaction,ongoing research,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11146227&form=6&db=m Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11193779&form=6&db=m Secretory lipophilins: a tale of two species. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11234884&form=6&db=m Mutations of PTEN/MMAC1 in primary prostate cancers from Chinese patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297763&form=6&db=m PTEN/MMAC1 in malignant melanoma and its importance for tumor progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11303623&form=6&db=m Immunocytochemical mapping of the phosphatase and tensin homolog (PTEN/MMAC1) tumor suppressor protein in human gliomas. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309275&form=6&db=m Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313308&form=6&db=m Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369059&form=6&db=m Analysis of PTEN/MMAC1 alteration in neuroblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11410335&form=6&db=m Expression, purification, characterization and homology modeling of active Akt/PKB, a key enzyme involved in cell survival signaling. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11463457&form=6&db=m Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11485247&form=6&db=m Is exon 5 of the PTEN/MMAC1 gene a prognostic marker in anaplastic glioma? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11504907&form=6&db=m An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11565871&form=6&db=m Association of increased phosphatidylinositol 3-kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585417&form=6&db=m Somatic mutations of the PTEN/NMAC1 gene associated with frequent chromosomal loss detected using comparative genomic hybridization in endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605070&form=6&db=m Mutational analysis of the PTEN/MMAC1 tumour suppressor gene in primary human malignant mesotheliomas. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11801303&form=6&db=m Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11810268&form=6&db=m The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11901476&form=6&db=m Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011252&form=6&db=m Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075083&form=6&db=m PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110043&form=6&db=m Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12191616&form=6&db=m Inhibition of protein kinase B/Akt. implications for cancer therapy. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203362&form=6&db=m CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414639&form=6&db=m Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12454773&form=6&db=m PTEN/MMAC1 expression in melanoma resection specimens. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12461771&form=6&db=m PTEN regulation of neural development and CNS stem cells. diagnostic usage,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12517798&form=6&db=m Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12543774&form=6&db=m Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12546364&form=6&db=m Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12569572&form=6&db=m PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12592384&form=6&db=m Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12695913&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12712134&form=6&db=m PTEN/MMAC1 mutations correlate inversely with an altered p53 tumor suppressor gene in gynecologic tumors. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727853&form=6&db=m PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12788938&form=6&db=m Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789288&form=6&db=m PTEN signaling pathways in melanoma. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12807996&form=6&db=m Cilostazol prevents tumor necrosis factor-alpha-induced cell death by suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and activation of Akt/cyclic AMP response element-binding protein phosphorylation. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12846407&form=6&db=m p53 and PTEN/MMAC1 mutational analysis of the small-intestinal cancer. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12857747&form=6&db=m Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14518258&form=6&db=m [PTEN/MMAC1 is apparently not a relevant tumor suppressor gene in development of hereditary breast carcinoma] causal interaction,ongoing research,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14559981&form=6&db=m Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14569058&form=6&db=m Cilostazol enhances casein kinase 2 phosphorylation and suppresses tumor necrosis factor-alpha-induced increased phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576666&form=6&db=m PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14583464&form=6&db=m Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605666&form=6&db=m Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14743465&form=6&db=m Long-term androgen-ablation causes increased resistance to PI3K/Akt pathway inhibition in prostate cancer cells. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14770419&form=6&db=m Mammalian target of rapamycin inhibition as therapy for hematologic malignancies. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15021905&form=6&db=m Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15086520&form=6&db=m Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15147864&form=6&db=m Bisperoxovanadium compounds are potent PTEN inhibitors. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231710&form=6&db=m Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15235134&form=6&db=m Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer. diagnostic usage,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15249580&form=6&db=m A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. diagnostic usage,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15483033&form=6&db=m Putting the rap on Akt. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15520204&form=6&db=m Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15570039&form=6&db=m Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15578076&form=6&db=m Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15679305&form=6&db=m Molecular genetic analysis of phosphatase and tensin homolog and p16 tumor suppressor genes in patients with malignant glioma. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15717329&form=6&db=m Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15782140&form=6&db=m Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15891996&form=6&db=m Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15896465&form=6&db=m Functional definition of relevant epitopes on the tumor suppressor PTEN protein. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15994292&form=6&db=m Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16003541&form=6&db=m Pilocytic astrocytoma presenting as primary diffuse leptomeningeal gliomatosis: report of a unique case and review of the literature. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16033830&form=6&db=m PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051596&form=6&db=m Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16061670&form=6&db=m Overexpression of the tumor suppressor gene phosphatase and tensin homologue partially inhibits wnt-1-induced mammary tumorigenesis. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16107342&form=6&db=m Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16145208&form=6&db=m Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166282&form=6&db=m Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170346&form=6&db=m Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16179839&form=6&db=m [Expression of PTEN and its correlation with angiogenesis in gastric carcinoma] causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16214396&form=6&db=m Hepatocyte-specific Pten-deficient mice as a novel model for nonalcoholic steatohepatitis and hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16220831&form=6&db=m Expression of PTEN in ovarian epithelial tumors and its relation to tumor behavior and growth. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16264263&form=6&db=m PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267832&form=6&db=m Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16294307&form=6&db=m Proteome profile changes that are differentially regulated by lipid and protein phosphatase activities of tumor suppressor PTEN in PTEN-expressing U-87 MG human glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357132&form=6&db=m Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16371366&form=6&db=m The Tumor Suppressor PTEN Is Necessary for Human Sprouty 2-mediated Inhibition of Cell Proliferation. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16373498&form=6&db=m PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16397245&form=6&db=m Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424010&form=6&db=m Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16425225&form=6&db=m Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16426222&form=6&db=m Expression of the PTEN tumor suppressor gene in malignant mammary gland tumors of dogs. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16452213&form=6&db=m Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16487009&form=6&db=m PTEN Promoter Methylation in Sporadic Thyroid Carcinomas. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16502258&form=6&db=m PTEN: A crucial mediator of mitochondria-dependent apoptosis. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16517411&form=6&db=m Expression of PTEN, cyclin D1, P27/KIP1 in invasive ductal carcinomas of the breast and correlation with clinicopathological parameters. diagnostic usage,ongoing research,unassigned 2,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16518410&form=6&db=m Fibronectin induces cell proliferation and inhibits apoptosis in human bronchial epithelial cells: pro-oncogenic effects mediated by PI3-kinase and NF-kappa B. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525657&form=6&db=m Alteration and clinical relevance of PTEN expression and its correlation with survivin expression in epithelial ovarian tumors. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16556075&form=6&db=m FOXO factors: a matter of life and death. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16574813&form=6&db=m Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16637073&form=6&db=m Conditional expression of PTEN alters the androgen responsiveness of prostate cancer cells. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16645045&form=6&db=m Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16675164&form=6&db=m Regulation of the PTEN phosphatase. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16719202&form=6&db=m Microdissection-based allelotyping: a novel technique to determine the temporal sequence and biological aggressiveness of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762633&form=6&db=m Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. causal interaction,therapeutic application,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778187&form=6&db=m p53 down-regulates phosphatase and tensin homologue deleted on chromosome 10 protein stability partially through caspase-mediated degradation in cells with proteasome dysfunction. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818626&form=6&db=m Epigenetic silencing of the PTEN gene in melanoma. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16871217&form=6&db=m Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16885338&form=6&db=m High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. causal interaction,ongoing research,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16971513&form=6&db=m Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996801&form=6&db=m PTEN in the haematopoietic system and its therapeutic indications. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17033968&form=6&db=m Mutation-positive and mutation-negative patients with Cowden and Bannayan-Riley-Ruvalcaba syndromes associated with distinct 10q haplotypes. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17097286&form=6&db=m Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17126809&form=6&db=m A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17166883&form=6&db=m In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis. diagnostic usage,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17167516&form=6&db=m Cancer phenomics: RET and PTEN as illustrative models. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17169462&form=6&db=m Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17213812&form=6&db=m A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17236582&form=6&db=m [Expression of epidermal growth factor receptor and PTEN in malignancy brain tumors] causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237784&form=6&db=m PTEN-deficient intestinal stem cells initiate intestinal polyposis. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17283152&form=6&db=m Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17299101&form=6&db=m Adipocyte enhancer-binding protein 1 modulates adiposity and energy homeostasis. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332319&form=6&db=m Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17346540&form=6&db=m Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17347137&form=6&db=m The role of PTEN in prostate cancer cell tropism to the bone micro-environment. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369847&form=6&db=m IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369849&form=6&db=m Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17373630&form=6&db=m Role of tumor suppressor PTEN in tumor necrosis factor alpha-induced inhibition of insulin signaling in murine skeletal muscle C2C12 cells. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17400585&form=6&db=m Mgat5 and Pten interact to regulate cell growth and polarity. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17420249&form=6&db=m Phosphorylated galectin-3 mediates tumor necrosis factor-related apoptosis-inducing ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast carcinoma cells. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513297&form=6&db=m Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17545604&form=6&db=m Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. ongoing research,therapeutic application,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17557954&form=6&db=m Phase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17605038&form=6&db=m Phosphoinositide phosphatases in a network of signalling reactions. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17605309&form=6&db=m Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17606718&form=6&db=m Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17643312&form=6&db=m PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17669465&form=6&db=m PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17681183&form=6&db=m MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17693663&form=6&db=m Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17699782&form=6&db=m Regulation of PTEN expression in intestinal epithelial cells by c-Jun NH2-terminal kinase activation and nuclear factor-kappaB inhibition. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17766839&form=6&db=m The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786367&form=6&db=m Loss of heterozygosity on chromosome 10q23 and mutation of the phosphatase and tensin homolog deleted from chromosome 10 tumor suppressor gene in Korean hepatocellular carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17827710&form=6&db=m PTEN: its deregulation and tumorigenesis. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17845801&form=6&db=m Restoring E-cadherin-mediated cell-cell adhesion increases PTEN protein level and stability in human breast carcinoma cells. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17894887&form=6&db=m OncomiRs: the discovery and progress of microRNAs in cancers. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17907961&form=6&db=m Focal adhesion kinase: a promising target for anticancer therapy. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17921358&form=6&db=m Conditional deletion of Pten causes bronchiolar hyperplasia. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928923&form=6&db=m Overexpression of PTEN Induces Cell Growth Arrest and Apoptosis in Human Breast Cancer ZR-75-1 Cells. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17954274&form=6&db=m Mutation of the PTEN gene in a human hepatic angiosarcoma. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17959258&form=6&db=m Phosphatase PTEN in neuronal injury and brain disorders. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17972252&form=6&db=m Why is PTEN an important tumor suppressor? causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974977&form=6&db=m Suppression of PTEN Expression Is Essential for Antiapoptosis and Cellular Transformation by Oncogenic Ras. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17998413&form=6&db=m Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006852&form=6&db=m Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18046441&form=6&db=m Mechanisms of Disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18046443&form=6&db=m T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055759&form=6&db=m Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18082231&form=6&db=m Expression and significance of PTEN in canine mammary gland tumours. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18166358&form=6&db=m PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18215105&form=6&db=m Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18245465&form=6&db=m Modeling genomic diversity and tumor dependency in malignant melanoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18248818&form=6&db=m PTEN expression is a strong predictor of survival in mesothelioma patients. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281487&form=6&db=m Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288941&form=6&db=m Deregulation of the Akt pathway in human cancer. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18347155&form=6&db=m Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18377423&form=6&db=m Correlation between NDRG1 and PTEN expression in endometrial carcinoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381417&form=6&db=m Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18429963&form=6&db=m Valproic acid resensitizes cisplatin-resistant ovarian cancer cells. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446851&form=6&db=m Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18460397&form=6&db=m Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18493606&form=6&db=m Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18524891&form=6&db=m Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18541712&form=6&db=m Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18558293&form=6&db=m A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559565&form=6&db=m Correlates and determinants of nuclear epidermal growth factor receptor content in an oropharyngeal cancer tissue microarray. causal interaction,ongoing research,unassigned 2,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18581057&form=6&db=m Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18616528&form=6&db=m Phosphatidylinositol 3-kinase inhibitors: promising drug candidates for cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18671162&form=6&db=m PTEN as a Unique Promising Therapeutic Target for Occupational Asthma. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18672141&form=6&db=m Hamartomatous polyposis syndromes. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18755892&form=6&db=m PTEN-deficient cancers depend on PIK3CB. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18772044&form=6&db=m PTEN-5-HT2C coupling: a new target for treating drug addiction. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18774962&form=6&db=m Increased Activated Akt Expression in Renal Cell Carcinomas and Prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794802&form=6&db=m Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794877&form=6&db=m PTEN signaling in brain: neuropathology and tumorigenesis. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794879&form=6&db=m PTEN: a new guardian of the genome. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18829560&form=6&db=m NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18830414&form=6&db=m PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18849498&form=6&db=m High dietary inorganic phosphate increases lung tumorigenesis and alters Akt signaling. diagnostic usage,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18950730&form=6&db=m Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19036165&form=6&db=m Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047102&form=6&db=m Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19048075&form=6&db=m Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19052170&form=6&db=m Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth factor-beta pathways in prostate cancer. causal interaction,diagnostic usage,unassigned 2,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19072831&form=6&db=m Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19075262&form=6&db=m Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19082655&form=6&db=m Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19095950&form=6&db=m Irs2 inactivation suppresses tumor progression in Pten+/- mice. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19096712&form=6&db=m PPARgamma, PTEN, and the Fight against Cancer. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19106660&form=6&db=m Molecule-targeted agents in endometrial cancer. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19114656&form=6&db=m A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. diagnostic usage,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116448&form=6&db=m Inhibition of LPS-induced cyclooxygenase 2 and nitric oxide production by transduced PEP-1-PTEN fusion protein in Raw 264.7 macrophage cells. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19142997&form=6&db=m Differential expression of PTEN in normal adult rat brain and upregulation of PTEN and p-Akt in the ischemic cerebral cortex. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19158375&form=6&db=m Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19168705&form=6&db=m Epithelial phosphatase and tensin homolog regulates intestinal architecture and secretory cell commitment and acts as a modifier gene in neoplasia. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19225041&form=6&db=m IGF1-induced AKT phosphorylation and cell proliferation are suppressed with the increase in PTEN during luteinization in human granulosa cells. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19285250&form=6&db=m Commentary on The Deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J, Pandolfi PP, Cancer Genetics Program, Beth Israel Deaconess Cancer Center and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19309364&form=6&db=m Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19319191&form=6&db=m Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. causal interaction,ongoing research,unassigned 2,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19372580&form=6&db=m Genetic alterations and oncogenic pathways associated with breast cancer subtypes. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19384426&form=6&db=m The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19395652&form=6&db=m PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19417140&form=6&db=m Interaction of E-cadherin and PTEN Regulates Morphogenesis and Growth Arrest in Human Mammary Epithelial Cells. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19429983&form=6&db=m Reduced PTEN protein expression and its prognostic implications in canine and feline mammary tumours. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19435893&form=6&db=m Loss of Phosphatase and Tensin Homologue Deleted on Chromosome 10 Engages ErbB3 and Insulin-Like Growth Factor-I Receptor Signaling to Promote Antiestrogen Resistance in Breast Cancer. causal interaction,ongoing research,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19436944&form=6&db=m The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activation. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19471547&form=6&db=m Pharmacogenomic profiling of the PI3K/PTEN pathway in sporadic breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19482022&form=6&db=m Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19492080&form=6&db=m Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19589091&form=6&db=m Novel inhibitors of the PI3K family. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661141&form=6&db=m Increased tissue factor expression is associated with reduced survival in non-small cell lung cancer and with mutations of TP53 and PTEN. diagnostic usage,ongoing research,unassigned 2,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19673018&form=6&db=m No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19683286&form=6&db=m Pathological effects of prostate cancer correlate with neuroendocrine differentiation and PTEN expression after bicalutamide monotherapy. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19724853&form=6&db=m PTEN expression and mutation in colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19787268&form=6&db=m Epigenetic modulation of PTEN expression during antiandrogenic therapies in human prostate cancer. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808258&form=6&db=m Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808964&form=6&db=m A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19832698&form=6&db=m Hypoxia aggravates nonalcoholic steatohepatitis in mice lacking hepatocellular PTEN. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843859&form=6&db=m Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19864456&form=6&db=m Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917848&form=6&db=m Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19932869&form=6&db=m In utero and lactational exposure to blueberry via maternal diet promotes mammary epithelial differentiation in prepubescent female rats. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956439&form=6&db=m AKT and PTEN expression in human gastrointestinal carcinoid tumors. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19965668&form=6&db=m PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20008304&form=6&db=m Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20019182&form=6&db=m Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20028743&form=6&db=m Mining tissue microarray data to uncover combinations of biomarker expression patterns that improve intermediate staging and grading of clear cell renal cell cancer. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20029030&form=6&db=m Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. causal interaction,ongoing research,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20049732&form=6&db=m Converting cancer mutations into therapeutic opportunities. therapeutic application,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20049735&form=6&db=m Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20079266&form=6&db=m [Mutation and expression of tumor suppressor gene phosphatase and tensin homolog deleted in chromosome 10 in oral squamous cell carcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20086174&form=6&db=m Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20100827&form=6&db=m Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20102402&form=6&db=m Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20129651&form=6&db=m Relationship between down-regulation of HIC1 and PTEN genes and dysfunction of pancreatic islet cells in diabetic rats. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133717&form=6&db=m Selective targeting of radiation-resistant tumor-initiating cells. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197621&form=6&db=m A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226014&form=6&db=m Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20300775&form=6&db=m PTEN mutation spectrum in breast cancers and breast hyperplasia. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20308550&form=6&db=m The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20360540&form=6&db=m Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20378992&form=6&db=m The adenovirus-mediated transfer of PTEN inhibits the growth of esophageal cancer cells in vitro and in vivo. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20464496&form=6&db=m Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20515662&form=6&db=m The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20516645&form=6&db=m Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20531234&form=6&db=m Role of phosphatase and tensin homolog in the development of the mammalian auditory system. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20554748&form=6&db=m PTEN and p53 cross-regulation induced by soy isoflavone genistein promotes mammary epithelial cell cycle arrest and lobuloalveolar differentiation. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20563661&form=6&db=m Targeting mTOR in cancer: renal cell is just a beginning. diagnostic usage,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20564403&form=6&db=m Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20615404&form=6&db=m Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20622047&form=6&db=m PI(3)king apart PTEN's role in cancer. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664988&form=6&db=m PTEN sensitizes MDA-MB-468 cells to inhibition of MEK/Erk signaling for the blockade of cell proliferation. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20705603&form=6&db=m A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20718038&form=6&db=m A mutant form of PTEN linked to autism. diagnostic usage,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20727948&form=6&db=m Phosphatase and tensin homolog deleted on chromosome 10 regulates sensory cell proliferation and differentiation of hair bundles in the mammalian cochlea. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20739887&form=6&db=m Epidermal growth factor receptor inhibitors in oncology. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20807096&form=6&db=m PTEN tumor suppressor plays less prognostic role than P53 tumor suppressor in diffuse large B-cell lymphoma. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20818428&form=6&db=m beta-Catenin activation synergizes with PTEN loss to cause bladder cancer formation. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20825972&form=6&db=m Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20832020&form=6&db=m Poly(ADP-ribose) polymerase inhibition as a model for synthetic lethality in developing radiation oncology targets. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20856158&form=6&db=m MicroRNA-21 Overexpression Contributes to Vestibular Schwannoma Cell Proliferation and Survival. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20943632&form=6&db=m Treatment of triple-negative metastatic breast cancer: toward individualized targeted treatments or chemosensitization? causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20962022&form=6&db=m Thyroid Nodules and Cancer in Children with PTEN Hamartoma Tumor Syndrome. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21035331&form=6&db=m Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21060037&form=6&db=m Oncophenotypic review and clinical correlates of phosphatase and tensin homolog on chromosome 10 hamartoma tumor syndrome. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21072054&form=6&db=m PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21078976&form=6&db=m MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21116717&form=6&db=m Mutational Analysis of the PTEN Gene and Its Effects in Esophageal Squamous Cell Carcinoma. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21127264&form=6&db=m Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21135276&form=6&db=m Loss of phosphatase and tensin homolog or phosphoinositol-3 kinase activation and response to trastuzumab or lapatinib in human epidermal growth factor receptor 2-overexpressing locally advanced breast cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21167305&form=6&db=m Moesin-ezrin-radixin-like protein (merlin) mediates protein interacting with the carboxyl terminus-1 (PICT-1)-induced growth inhibition of glioblastoma cells in the nucleus. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21177507&form=6&db=m Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21181309&form=6&db=m Expression of PTTG1 and PTEN in endometrial carcinoma: correlation with tumorigenesis and progression. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21190448&form=6&db=m Thyroid pathology in PTEN-hamartoma tumor syndrome: characteristic findings of a distinct entity. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21194879&form=6&db=m Clinical significance of tumor suppressor PTEN in colorectal carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205925&form=6&db=m Activation of phosphatidylinositol 3-kinase/akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21236500&form=6&db=m Non-genomic loss of PTEN function in cancer: not in my genes. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21278789&form=6&db=m Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21345072&form=6&db=m The Protective Effect of Cu/Zn-SOD Against Oxidative Stress After PTEN Deletion. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21359530&form=6&db=m miR-29b regulates migration of human breast cancer cells. causal interaction,ongoing research,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360018&form=6&db=m PTEN's regulation of VEGF and VEGFR1 expression and its clinical significance in myeloid leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21361912&form=6&db=m Enhanced lymphocyte interferon (IFN)-? responses in a PTEN mutation-negative Cowden disease kindred. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21385900&form=6&db=m CREB is a Novel Nuclear Target of PTEN Phosphatase. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21419611&form=6&db=m Targeting the dysregulated mammalian target of rapamycin pathway in organ transplantation: killing 2 birds with 1 stone. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468554&form=6&db=m Estrogen receptor ? induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21472313&form=6&db=m Methylation status of the PTEN gene in adenoid cystic carcinoma cells. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21505227&form=6&db=m Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21520171&form=6&db=m Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21529704&form=6&db=m Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21543766&form=6&db=m Kruppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen. causal interaction,ongoing research,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21568903&form=6&db=m Targeting PDK1 in cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21613227&form=6&db=m MicroRNA-21 Orchestrates High Glucose-induced Signals to TOR Complex 1, Resulting in Renal Cell Pathology in Diabetes. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21617855&form=6&db=m Caffeine activates tumor suppressor PTEN in sarcoma cells. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21627959&form=6&db=m ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21641013&form=6&db=m Activation of the phosphatidylinositol 3'-kinase/AKT pathway in neuroblastoma and its regulation by thioredoxin 1. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21752881&form=6&db=m FOXO3 Is Inhibited by Oncogenic PI3K/Akt Signaling but Can Be Reactivated by the NSAID Sulindac Sulfide. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21788564&form=6&db=m Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801466&form=6&db=m Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21804542&form=6&db=m Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21804599&form=6&db=m PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21819957&form=6&db=m PTEN on Chromosome 10 Is Phosphorylated in Primary Effusion Lymphoma and Kaposi's Sarcoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21837670&form=6&db=m The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21847361&form=6&db=m Persistent inflammation leads to proliferative neoplasia and loss of smooth muscle cells in a prostate tumor model. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21861842&form=6&db=m The Phosphoinositide 3-Kinase Signaling Pathway as a Therapeutic Target in Grade IV Brain Tumors. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21869593&form=6&db=m Lentivirus-mediated RNA interference targeting E2F-1 inhibits human gastric cancer MGC-803 cell growth in vivo. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21890461&form=6&db=m Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21904550&form=6&db=m The Role of PTEN in Tumor Angiogenesis. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21909134&form=6&db=m Identification of microprocessor-dependent cancer cells allows screening for growth-sustaining micro-RNAs. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21943825&form=6&db=m Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells. causal interaction,ongoing research,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21945955&form=6&db=m Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21960672&form=6&db=m Phosphatase and Tensin Homolog (PTEN) Gene Mutations and Autism: Literature Review and a Case Report of a Patient With Cowden Syndrome, Autistic Disorder and Epilepsy. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21998291&form=6&db=m GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22018627&form=6&db=m Colonic ganglioneuromatous polyposis and metastatic adenocarcinoma in the setting of Cowden syndrome: a case report and literature review. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22110200&form=6&db=m Differential Akt signalling in non-seminomatous testicular germ cell tumors. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22166214&form=6&db=m MicroRNA-22 promotes cell survival upon UV radiation by repressing PTEN. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179576&form=6&db=m Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22209294&form=6&db=m PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3'-kinase pathway alterations might be associated with favorable prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22209699&form=6&db=m PTEN Regulates PDGF Ligand Switch for ?-PDGFR Signaling in Prostate Cancer. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22219179&form=6&db=m Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22240798&form=6&db=m Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266095&form=6&db=m PTEN in DNA damage repair. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22276040&form=6&db=m PTEN breast cancer susceptibility: a matter of dose. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22281088&form=6&db=m Clinicopathologic and Molecular Analysis of a Choroidal Pigmented Schwannoma in the Context of a PTEN Hamartoma Tumor Syndrome. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22287727&form=6&db=m Quantitative MRI establishes the efficacy of PI3K inhibitor (GDC-0941) multi-treatments in PTEN-deficient mice lymphoma. ongoing research,therapeutic application,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22322462&form=6&db=m microRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340721&form=6&db=m Protein tyrosine phosphatases in cancer: friends and foes! causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22350790&form=6&db=m Diagnostic potential of PTEN-targeting miR-214 in the blood of breast cancer patients. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371648&form=6&db=m A case of Cowden syndrome diagnosed from multiple gastric polyposis. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22375056&form=6&db=m PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22462691&form=6&db=m The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22473468&form=6&db=m The functions and regulation of the PTEN tumour suppressor. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22481094&form=6&db=m New insights in the activity of voltage sensitive phosphatases. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22489661&form=6&db=m Radiation/paclitaxel treatment of p53-abnormal non-small cell lung cancer xenograft tumor and associated mechanism. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22494966&form=6&db=m Mesenchymal stem cell signaling in cancer progression. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22503752&form=6&db=m Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor ?. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22511720&form=6&db=m Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22516257&form=6&db=m Targeting nonclassical oncogenes for therapy in T-ALL. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22524426&form=6&db=m Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3K? inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22562138&form=6&db=m A glutamate switch controls voltage-sensitive phosphatase function. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22623890&form=6&db=m PTEN gene: a model for genetic diseases in dermatology. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22645351&form=6&db=m 3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22672595&form=6&db=m Is colorectal surveillance indicated in patients with PTEN mutations? causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22672749&form=6&db=m KRAS Mutation Status and Clinical Outcome of Preoperative Chemoradiation With Cetuximab in Locally Advanced Rectal Cancer: A Pooled Analysis of 2 Phase II Trials. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22674257&form=6&db=m STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and Transformation. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22684500&form=6&db=m Androgen-independent prostate cancer cells circumvent EGFR inhibition by overexpression of alternative HER receptors and ligands. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22700876&form=6&db=m PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22700976&form=6&db=m Metastasis-associated Protein 1/Histone Deacetylase 4-Nucleosome Remodeling and Deacetylase Complex Regulates Phosphatase and Tensin Homolog Gene Expression and Function. ongoing research,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706993&form=6&db=m Inhibition of T-cell activation by PIK3IP1. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22713753&form=6&db=m SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22737980&form=6&db=m PTEN regulation of ERK1/2 signaling in cancer. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22740940&form=6&db=m Overexpression of DJ-1 and HSP90?, and loss of PTEN associated with invasive urothelial carcinoma of urinary bladder: Possible prognostic markers. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22846175&form=6&db=m SUMO, PTEN and Tumor Suppression. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848291&form=6&db=m Expression of PPAR? and PTEN in human colorectal cancer: An immunohistochemical study using tissue microarray methodology. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22853427&form=6&db=m Sequence-Dependent Synergistic Inhibition of Human Glioma Cell Lines by Combined Temozolomide and miR-21 Inhibitor Gene Therapy. therapeutic application,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22864686&form=6&db=m The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22886792&form=6&db=m Loss of p(Ser2448) -mTOR expression is linked to adverse prognosis and tumor progression in ERG-fusion-positive cancers. diagnostic usage,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22891331&form=6&db=m Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22902055&form=6&db=m New insights into PTEN regulation mechanisms and its potential function in targeted therapies. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22906543&form=6&db=m Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid-induced neurodegeneration model. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22907762&form=6&db=m Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22920963&form=6&db=m Prognosis of patients with multifocal glioblastoma: a case-control study. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22939387&form=6&db=m Potentiation of Inflammatory CXCL8 Signalling Sustains Cell Survival in PTEN-deficient Prostate Carcinoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22956625&form=6&db=m Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22962422&form=6&db=m PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22975517&form=6&db=m Development of an immunohistochemical protein quantification system in conjunction with tissue microarray technology for identifying predictive biomarkers for phosphatidylinositol 3-kinase inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22981675&form=6&db=m Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982652&form=6&db=m Loss of Phosphatase and Tensin Homolog Protein Expression Is an Independent Poor Prognostic Marker in Lung Adenocarcinoma. causal interaction,diagnostic usage,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993301&form=6&db=m Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-?B and MAPK pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23012657&form=6&db=m The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23013295&form=6&db=m Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23018874&form=6&db=m PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23023298&form=6&db=m microRNA-181a is associated with poor prognosis of colorectal cancer. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23062208&form=6&db=m Association between PTEN IVS4 polymorphism and development of colorectal cancer in a Turkish population. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23118026&form=6&db=m Phosphatase and tensin homolog regulates stability and activity of EphB1 receptor. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23125220&form=6&db=m MicroRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23146303&form=6&db=m Preventive effects of AdR-siPTEN through the regulation of NMDA receptor NR2B subunit in trigeminal ganglia of migraine rats. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23171049&form=6&db=m Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23180960&form=6&db=m Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis? causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23205120&form=6&db=m Immunohistochemical expression of mTOR negatively correlates with PTEN expression in gastric carcinoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23210979&form=6&db=m Roles of Polo-like kinase 3 in suppressing tumor angiogenesis. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23211529&form=6&db=m G protein-coupled receptor-mediated activation of p110? by G?? is required for cellular transformation and invasiveness. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23221380&form=6&db=m Increase of fatty acid oxidation and VLDL assembly and secretion overexpression of PTEN in cultured hepatocytes of newborn calf. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23239438&form=6&db=m Monitoring the development of xenograft triple-negative breast cancer models using diffusion-weighted magnetic resonance imaging. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23251242&form=6&db=m Loss and reduced expression of PTEN correlate with advanced-stage gastric carcinoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23258740&form=6&db=m Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23260327&form=6&db=m Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23273076&form=6&db=m High levels of phosphatase and tensin homolog expression are associated with tumor progression, tumor recurrence, and systemic metastases in pT1 urothelial carcinoma of the bladder: a tissue microarray study of 156 patients treated by transurethral resection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23276799&form=6&db=m PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23289868&form=6&db=m Effects of Tacrolimus and Nifedipine Alone or in Combination on the Gingival Tissues. diagnostic usage,ongoing research,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23313933&form=6&db=m Redox regulation of tumor suppressor PTEN in cancer and aging (Review). causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319880&form=6&db=m Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23323157&form=6&db=m Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23382286&form=6&db=m PTEN suppresses SPARC-induced pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in glioma. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23382303&form=6&db=m Brothers with germline PTEN mutations and persistent hypoglycemia, macrocephaly, developmental delay, short stature, and coagulopathy. diagnostic usage,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23393595&form=6&db=m Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23411347&form=6&db=m Novel approaches to inhibitor design for the p110? phosphoinositide 3-kinase. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23423780&form=6&db=m Autosomal Dominant Inherited Cowden's Disease in a Family. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23431164&form=6&db=m DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23462369&form=6&db=m Caffeic acid phenethyl ester as an adjuvant therapy for advanced prostate cancer. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23465274&form=6&db=m Altered PTEN function caused by deletion or gene disruption is associated with poor prognosis in rectal but not in colon cancer. causal interaction,therapeutic application,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23466879&form=6&db=m Caffeic Acid phenethyl ester as a potential treatment for advanced prostate cancer targeting akt signaling. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23470565&form=6&db=m Enhanced tumor suppression by adenoviral PTEN gene therapy combined with cisplatin chemotherapy in small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23471434&form=6&db=m Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23500889&form=6&db=m Cytosolic phospholipase A2? sustains pAKT, pERK and AR levels in PTEN-null/mutated prostate cancer cells. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23514585&form=6&db=m PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23546593&form=6&db=m Expression and significance of PTEN and miR-92 in hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23552841&form=6&db=m Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23582881&form=6&db=m Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08). causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23595342&form=6&db=m Role of PTEN in cholera toxin-induced SWO?38 glioma cell differentiation. causal interaction,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23623571&form=6&db=m Restoration of PTEN activity decreases metastases in an orthotopic model of colon cancer. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625632&form=6&db=m Role of PTEN in Basal Cell Derived Lung Carcinogenesis. causal interaction,ongoing research,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23662813&form=6&db=m E- to N-cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23663432&form=6&db=m Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23665199&form=6&db=m Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23691291&form=6&db=m Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23741314&form=6&db=m Hydrogen sulfide prevents hydrogen peroxide-induced activation of epithelial sodium channel through a PTEN/PI(3,4,5)P3 dependent pathway. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23744781&form=6&db=m A secreted PTEN phosphatase that enters cells to alter signaling and survival. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23764776&form=6&db=m A neuroprotective phase precedes striatal degeneration upon nucleolar stress. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23776211&form=6&db=m Genetic reconstitution of tumorigenesis in primary intestinal cells. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23798791&form=6&db=m Phosphatase and tensin homologue deleted on chromosome 10. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23820386&form=6&db=m Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23840064&form=6&db=m PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23853470&form=6&db=m Cowden syndrome- Clinico-radiological illustration of a rare case. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23883586&form=6&db=m Synthetic Lethal Targeting of PTEN-Deficient Cancer Cells Using Selective Disruption of Polynucleotide Kinase/Phosphatase. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23888040&form=6&db=m Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23908595&form=6&db=m A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy. causal interaction,diagnostic usage,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23909904&form=6&db=m Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23937094&form=6&db=m Mannan-Conjugated Adenovirus Enhanced Gene Therapy Effects on Murine Hepatocellular Carcinoma Cells in Vitro and in Vivo. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24053326&form=6&db=m Blockade of reactive oxygen species and Akt activation is critical for anti-inflammation and growth inhibition of metformin in phosphatase and tensin homolog-deficient RAW264.7 cells. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24054978&form=6&db=m The multiple layers of non-genetic regulation of PTEN tumour suppressor activity. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062990&form=6&db=m Genomic Rearrangements of PTEN in Prostate Cancer. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24076665&form=6&db=m Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24083111&form=6&db=m Expression of PIK3CA, PTEN mRNA and PIK3CA mutations in primary breast cancer: association with lymph node metastases. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098737&form=6&db=m Four MicroRNAs Promote Prostate Cell Proliferation with Regulation of PTEN and Its Downstream Signals In Vitro. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24101387&form=6&db=m The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24123284&form=6&db=m The relationship between and clinical significance of MicroRNA-32 and phosphatase and tensin homologue expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24124088&form=6&db=m Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24136893&form=6&db=m Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24137349&form=6&db=m MicroRNA-92 regulates cervical tumorigenesis and its expression is upregulated by human papillomavirus-16 E6 in cervical cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24141770&form=6&db=m PTEN functions as a melanoma tumor suppressor by promoting host immune response. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24155249&form=6&db=m PTEN regulates matrix synthesis in adult human chondrocytes under oxidative stress. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24168180&form=6&db=m Downregulation of PTEN expression in psoriatic lesions. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24168499&form=6&db=m The expression of PTEN is associated with improved prognosis in patients with ampullary adenocarcinoma after pancreaticoduodenectomy. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24179529&form=6&db=m Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell lines. causal interaction,therapeutic application,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24202336&form=6&db=m Emerging biomarkers in glioblastoma. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24252318&form=6&db=m The expression of PTEN in the development of mouse cochlear lateral wall. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24270409&form=6&db=m Sprouty1 induces a senescence-associated secretory phenotype by regulating NF?B activity: implications for tumorigenesis. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24270425&form=6&db=m AKT activation promotes PTEN hamartoma tumor syndrome-associated cataract development. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24291216&form=6&db=m The end of KRAS, and other, cancers? A new way forward. therapeutic application,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24292675&form=6&db=m The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24292679&form=6&db=m Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24296317&form=6&db=m Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24317448&form=6&db=m BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379037&form=6&db=m Thyroid involvement in two patients with Bannayan-Riley-Ruvalcaba syndrome. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24387221&form=6&db=m Discovery and optimization of pyrimidone indoline amide PI3K? inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers. causal interaction,therapeutic application,unassigned 2,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24387334&form=6&db=m Therapeutic targeting of cancers with loss of PTEN function. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24457075&form=6&db=m Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24475377&form=6&db=m Functions and Regulation of the PTEN Gene in Colorectal Cancer. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486402&form=6&db=m PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24529624&form=6&db=m All-in-One inducible lentiviral vector systems based on drug controlled FLP recombinase. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24532317&form=6&db=m Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells. causal interaction,therapeutic application,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24587660&form=6&db=m Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24596386&form=6&db=m Tumor Suppressor PTEN in Breast Cancer: Heterozygosity, Mutations and Protein Expression. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24598081&form=6&db=m Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24604064&form=6&db=m Aberrant CpG island methylation of PTEN is an early event in nasopharyngeal carcinoma and a potential diagnostic biomarker. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24604594&form=6&db=m Signals Controlling Un-Differentiated States in Embryonic Stem and Cancer Cells: Role of the Phosphatidylinositol 3' Kinase Pathway. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24627690&form=6&db=m Altered Expression of PTEN and Its Major Regulator MicroRNA-21 in Pulmonary Neuroendocrine Tumors. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24632578&form=6&db=m Combined Effects of Genetic Variants of the PTEN, AKT1, MDM2 and p53 Genes on the Risk of Nasopharyngeal Carcinoma. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24632614&form=6&db=m Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24633304&form=6&db=m Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24647592&form=6&db=m PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: Two hits on the gene? unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24656806&form=6&db=m PTEN function: the long and the short of it. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24659669&form=6&db=m MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24669193&form=6&db=m Cancer cell-oriented migration of mesenchymal stem cells engineered with an anticancer gene (PTEN): an imaging demonstration. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24680176&form=6&db=m Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. causal interaction,ongoing research,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24721394&form=6&db=m Combined PTEN Mutation and Protein Expression Associate with Overall and Disease-Free Survival of Glioblastoma Patients. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24737887&form=6&db=m PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24740298&form=6&db=m Human fibroblast reprogramming to pluripotent stem cells regulated by the miR19a/b-PTEN axis. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24743220&form=6&db=m Frequent mono-allelic loss associated with deficient PTEN expression in imatinib-resistant gastrointestinal stromal tumors. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24748654&form=6&db=m Ectodomain-specific E-cadherin antibody suppresses skin SCC growth and reduces tumor grade: a multitargeted therapy modulating RTKs and the PTEN-p53-MDM2 axis. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24762546&form=6&db=m Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24838932&form=6&db=m Genetics of endometrial cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24844349&form=6&db=m Rapid estrogen signaling negatively regulates PTEN activity through phosphorylation in endometrial cancer cells. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24854395&form=6&db=m Galectin-3 and PTEN expression in pancreatic ductal adenocarcinoma, pancreatic neuroendocrine neoplasms and gastrointestinal tumors on fine-needle aspiration cytology. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24862260&form=6&db=m Regulation of cancer metabolism by oncogenes and tumor suppressors. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24862762&form=6&db=m NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24875179&form=6&db=m PTEN degradation after ischemic stroke: a double-edged sword. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24901890&form=6&db=m Association between PTEN Gene IVS4 polymorphism and risk of cancer: a meta-analysis. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24914051&form=6&db=m MicroRNA-382 induced by HIF-1? is an angiogenic miR targeting the tumor suppressor phosphatase and tensin homolog. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24935469&form=6&db=m The association of phosphatase and tensin homolog deleted on chromosome 10 polymorphisms and lifestyle habits with colorectal cancer risk in a Chinese population. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24979808&form=6&db=m Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25003471&form=6&db=m PTEN expression in patients with carcinoma of the cervix and its association with p53, Ki-67 and CD31. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25015038&form=6&db=m TMPRSS2-ERG Fusions Are Strongly Linked to Young Patient Age in Low-grade Prostate Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25024751&form=6&db=m Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25047426&form=6&db=m Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054006&form=6&db=m Promoter region methylation and loss of protein expression of PTEN and significance in cervical cancer. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25069680&form=6&db=m Effect of the PTEN gene on adhesion, invasion and metastasis of osteosarcoma cells. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120657&form=6&db=m Phosphatase and tensin homolog overexpression decreases proliferation and invasion and increases apoptosis in oral squamous cell carcinoma cells. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124605&form=6&db=m miRNA-1297 induces cell proliferation by targeting phosphatase and tensin homolog in testicular germ cell tumor cells. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25132272&form=6&db=m TGF-? signaling alters the pattern of liver tumorigenesis induced by Pten inactivation. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25170002&form=6&db=m Oral manifestations of phosphatase and tensin homolog hamartoma tumor syndrome: a report of three cases. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25171299&form=6&db=m Phosphorylated Akt Expression as a Favorable Prognostic Factor for Patients Undergoing Curative Resection and Adjuvant Chemoradiotherapy for Proximal Extrahepatic Bile Duct Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25197177&form=6&db=m Expression of phosphatase and tensin homolog, epidermal growth factor receptor, and Ki-67 in astrocytoma: A prospective study in a tertiary care hospital. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25216078&form=6&db=m A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25224693&form=6&db=m Analysis of PTEN ubiquitylation and SUMOylation using molecular traps. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25263454&form=6&db=m A new class of cancer-associated PTEN mutations defined by membrane translocation defects. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25336918&form=6&db=m Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337560&form=6&db=m Steroid hormone intervenes in the endometrial tumorigenesis of pten ablation. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25341069&form=6&db=m Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25348345&form=6&db=m Phosphorylated insulin-like growth factor-1 receptor expression predicts poor prognosis of Chinese patients with gastric cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25361917&form=6&db=m Molecular pathways: intercellular PTEN and the potential of PTEN restoration therapy. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25394489&form=6&db=m PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25403688&form=6&db=m PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25426449&form=6&db=m Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25427907&form=6&db=m Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25429968&form=6&db=m Phospholipid-binding Sites of Phosphatase and Tensin Homolog (PTEN): EXPLORING THE MECHANISM OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE ACTIVATION. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25447674&form=6&db=m Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25454616&form=6&db=m PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25461771&form=6&db=m PTEN Hamartoma Tumor Syndrome: Clinical Risk Assessment and Management Protocol. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25469115&form=6&db=m PTEN and Ki67 expression is associated with clinicopathologic features of non-small cell lung cancer. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25547115&form=6&db=m Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25607987&form=6&db=m Catalysis by the tumor-suppressor enzymes PTEN and PTEN-L. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25613699&form=6&db=m PTEN and hTERT gene expression and the correlation with human hepatocellular carcinoma. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25621296&form=6&db=m WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25644446&form=6&db=m PTEN ceRNA networks in human cancer. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25682871&form=6&db=m Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701228&form=6&db=m Saccharomyces cerevisiae-like 1 overexpression is frequent in prostate cancer and has markedly different effects in Ets-related gene fusion-positive and fusion-negative cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25722686&form=6&db=m Isolation, cultivation and identification of brain glioma stem cells by magnetic bead sorting. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25751063&form=6&db=m A versatile modular vector system for rapid combinatorial mammalian genetics. therapeutic application,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25771877&form=6&db=m Phosphorylation of PTEN at STT motif is associated with DNA damage response. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789042&form=6&db=m Screening for germline phosphatase and tensin homolog-mutations in suspected Cowden syndrome and Cowden syndrome-like families among uterine cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25873394&form=6&db=m Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-?B Pathway. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881601&form=6&db=m CDX2 inhibits invasion and migration of gastric cancer cells by phosphatase and tensin homologue deleted from chromosome 10/Akt signaling pathway. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25884169&form=6&db=m Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25889774&form=6&db=m Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain. ongoing research,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25892179&form=6&db=m DJ-1-induced phosphatase and tensin homologue downregulation is associated with proliferative and invasive activity of laryngeal cancer cells. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25913390&form=6&db=m Genomic Predictors of Outcome in Prostate Cancer. causal interaction,ongoing research,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916396&form=6&db=m Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25925379&form=6&db=m Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25925849&form=6&db=m PTEN expression in endothelial cells is down-regulated by uPAR to promote angiogenesis. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25927309&form=6&db=m The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25939393&form=6&db=m A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26009879&form=6&db=m Concurrent deletion of 16q23 and PTEN is an independent prognostic feature in prostate cancer. diagnostic usage,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26025112&form=6&db=m Letter regarding Xiao WZ et al. entitled "Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis". causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26061565&form=6&db=m FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26082588&form=6&db=m Cowden Syndrome with a Novel Germline PTEN Mutation and an Unusual Clinical Course. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26107225&form=6&db=m Loss of Expression of PTEN is Associated with Worse Prognosis in Patients with Cancer. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26114084&form=6&db=m PTEN sequence analysis in endometrial hyperplasia and endometrial carcinoma in Slovak women. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26120150&form=6&db=m Cowden Syndrome: Case Report, Update and Proposed Diagnostic and Surveillance Routines. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26208235&form=6&db=m Colonic polyps and polyposis syndromes in pediatric patients. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26223264&form=6&db=m Predicting the combined effect of multiple genetic variants. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26232326&form=6&db=m PTEN gene polymorphisms and susceptibility to oral squamous cell carcinoma in a Chinese Han population. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26232589&form=6&db=m The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26233892&form=6&db=m Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251180&form=6&db=m Focal adhesion kinase phosphorylates the phosphatase and tensin homolog deleted on chromosome 10 under the control of p110? phosphoinositide-3 kinase. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26264443&form=6&db=m Phosphatase and tensin homolog deleted on chromosome 10 contributes to phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis via multiple pathways. causal interaction,ongoing research,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26279303&form=6&db=m PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26284192&form=6&db=m Focus on PTEN Regulation. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26285119&form=6&db=m MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26285813&form=6&db=m Androgen actions via androgen receptor promote PTEN inactivation induced uterine cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26299428&form=6&db=m Peroxisome proliferator-activated receptor-? inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26316702&form=6&db=m PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26329580&form=6&db=m Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26350292&form=6&db=m Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26385178&form=6&db=m Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-?. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26399523&form=6&db=m PTEN regulates cilia through Dishevelled. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26415504&form=6&db=m AIF inhibits tumor metastasis by protecting PTEN from oxidation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26417029&form=6&db=m Impact of PTEN IVS4 Polymorphism (rs3830675) on Cancer Susceptibility: An Updated Meta-analysis. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26432332&form=6&db=m MicroRNA-92a promotes growth, metastasis, and chemoresistance in non-small cell lung cancer cells by targeting PTEN. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26443523&form=6&db=m Changes in the transcriptome of bovine ovarian cortex during follicle activation in vitro. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26458406&form=6&db=m DNA methylation inhibitor, decitabine, promotes MGC803 gastric cancer cell migration and invasion via the upregulation of NEDD4?1. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468640&form=6&db=m Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26488716&form=6&db=m Dermatofibrosarcoma Protuberans in a Patient With Cowden Syndrome: Revisiting the PTEN and PDGF Pathways. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26504226&form=6&db=m Discovery and functional characterization of a neomorphic PTEN mutation. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26511486&form=6&db=m Methylseleninic Acid Superactivates p53-Senescence Cancer Progression Barrier in Prostate Lesions of Pten-Knockout Mouse. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26526582&form=6&db=m Prognostic tissue biomarker exploration for patients with metastatic renal cell carcinoma receiving vascular endothelial growth factor receptor tyrosine kinase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26527737&form=6&db=m The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26564429&form=6&db=m Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26589417&form=6&db=m Overexpression of microRNA-30a-5p inhibits liver cancer cell proliferation and induces apoptosis by targeting MTDH/PTEN/AKT pathway. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26604880&form=6&db=m PTEN inhibition and axon regeneration and neural repair. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26612480&form=6&db=m Phase II study of everolimus in refractory testicular germ cell tumors. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622832&form=6&db=m Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629823&form=6&db=m Non-Specific Blocking of miR-17-5p Guide Strand in Triple Negative Breast Cancer Cells by Amplifying Passenger Strand Activity. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26649861&form=6&db=m Upregulation of PTEN suppresses invasion in Tca8113 tongue cancer cells through repression of epithelial-mesenchymal transition (EMT). causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26655726&form=6&db=m The PTEN tumor suppressor gene and its role in lymphoma pathogenesis. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26659571&form=6&db=m RANKL blockade prevents and treats aggressive osteosarcomas. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26678657&form=6&db=m Neuroendocrine Tumor of the Pancreas as a Manifestation of Cowden Syndrome: A Case Report. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680819&form=6&db=m Clinical Analysis of PTEN, p53 and Her-2/neu Expressions in Thyroid Cancers. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26686085&form=6&db=m Tumor-suppressor NF?B2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26687648&form=6&db=m PTEN and p16 genes as epigenetic biomarkers in oral squamous cell carcinoma (OSCC): a study on south Indian population. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691865&form=6&db=m IL-6/STAT3/ARF: the guardians of senescence, cancer progression and metastasis in prostate cancer. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26701969&form=6&db=m miR-21 Is Linked to Glioma Angiogenesis: A Co-Localization Study. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26718740&form=6&db=m Activation of Toll?like receptor 7 regulates the expression of IFN??1, p53, PTEN, VEGF, TIMP?1 and MMP?9 in pancreatic cancer cells. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26721874&form=6&db=m Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26725440&form=6&db=m Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26726007&form=6&db=m Biomarkers That Predict Sensitivity to Heat Shock Protein 90 Inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26764128&form=6&db=m FGFR and PTEN signaling interact during lens development to regulate cell survival. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26775196&form=6&db=m First application of the Automated QUantitative Analysis (AQUA) technique to quantify PTEN protein expression in ovarian cancer: A correlative study of NCIC CTG OV.16. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26794644&form=6&db=m A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26795104&form=6&db=m A longitudinally extensive myelopathy associated with multiple spinal arteriovenous fistulas in a patient with Cowden syndrome: a case report. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26830028&form=6&db=m CD10 expression in the neuroendocrine carcinoma component of endometrial mixed carcinoma: association with long survival. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26846484&form=6&db=m Effects of the tumor suppressor PTEN on the pathogenesis of idiopathic pulmonary fibrosis in Chinese patients. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26848951&form=6&db=m Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26854490&form=6&db=m Promoter Methylation of PTEN Is a Significant Prognostic Factor in Melanoma Survival. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26864202&form=6&db=m Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26869029&form=6&db=m PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870247&form=6&db=m Expression of PTEN and KAI1 tumor suppressor genes in pancreatic carcinoma and its association with different pathological factors. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26905328&form=6&db=m Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26919320&form=6&db=m Molecular diagnostics of gliomas using next generation sequencing of a glioma-tailored gene panel. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26932665&form=6&db=m Pulmonary atypical carcinoid in a patient with Cowden syndrome. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26943752&form=6&db=m Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26974310&form=6&db=m PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26975628&form=6&db=m Genodermatosis Affecting the Skin and Mucosa of the Head and Neck: Clinicopathologic, Genetic, and Molecular Aspect-PTEN-Hamartoma Tumor Syndrome/Cowden Syndrome. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26986476&form=6&db=m PTEN enhances G2/M arrest in etoposide-treated MCF?7 cells through activation of the ATM pathway. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27004535&form=6&db=m Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27033073&form=6&db=m Rapid Detection of Dynamic PTEN Regulation in Living Cells Using Intramolecular BRET. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27049078&form=6&db=m A novel quantitative method of pten expression assessment in tumor tissue. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27071790&form=6&db=m mTOR, a Potential Target to Treat Autism Spectrum Disorder. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27104955&form=6&db=m Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27105569&form=6&db=m Multiple Intracranial Arteriovenous Fistulas in Cowden Syndrome. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27115058&form=6&db=m Calcium-Sensing Receptor Tumor Expression and Lethal Prostate Cancer Progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27176210&form=6&db=m (?)?Epigallocatechin?3?gallate induces apoptosis in human pancreatic cancer cells via PTEN. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27179559&form=6&db=m Significance of microRNA 21 in gastric cancer. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27223069&form=6&db=m Higher methylation intensity induced by EBV LMP1 via NF-?B/ DNMT3b signaling contributes to silencing of PTEN gene. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27229116&form=6&db=m The clinical correlation of phosphatase and tensin homolog on chromosome 10, phosphorylation of AKT to an activated state, and odontogenic ameloblast-associated protein in gastrointestinal stromal tumors. causal interaction,therapeutic application,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270534&form=6&db=m MiR-106b-5p Inhibits Tumor Necrosis Factor-?-induced Apoptosis by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 in Vascular Endothelial Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27326759&form=6&db=m Involvement of IGF-2, IGF-1R, IGF-2R and PTEN in development of human tooth germ - an immunohistochemical study. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27347153&form=6&db=m Power of PTEN/AKT: Molecular switch between tumor suppressors and oncogenes. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27370400&form=6&db=m Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27379838&form=6&db=m MicroRNA-205-5p is upregulated in myelodysplastic syndromes and induces cell proliferation via PTEN suppression. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27381359&form=6&db=m Genetic profile of PTEN gene in Indian oral squamous cell carcinoma primary tumors. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27385366&form=6&db=m A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27401955&form=6&db=m Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27405757&form=6&db=m Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27421660&form=6&db=m Adenovirus-mediated co-expression of ING4 and PTEN cooperatively enhances their antitumor activity in human hepatocellular carcinoma cells. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27438149&form=6&db=m Establishment and antitumor effects of dasatinib and PKI-587 in BD-138T, a patient-derived muscle invasive bladder cancer preclinical platform with concomitant EGFR amplification and PTEN deletion. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27445490&form=6&db=m Combined treatment with everolimus and fulvestrant reversed anti-HER2 resistance in a patient with refractory advanced breast cancer: a case report. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446408&form=6&db=m PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470558&form=6&db=m The association of Phosphatase and tensin homolog (PTEN) deletion and prostate cancer risk: A meta-analysis. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27471403&form=6&db=m Genetic basis of Cowden syndrome and its implications for clinical practice and risk management. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27475963&form=6&db=m PTEN alterations of the stromal cells characterise an aggressive subpopulation of pancreatic cancer with enhanced metastatic potential. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481051&form=6&db=m Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27489861&form=6&db=m Hidden association of Cowden syndrome, PTEN mutation and meningioma frequency. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506936&form=6&db=m PTEN expression is a prognostic marker for patients with non-small cell lung cancer: a systematic review and meta-analysis of the literature. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27506975&form=6&db=m Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27581456&form=6&db=m Reassembly of Excitable Domains after CNS Axon Regeneration. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27582570&form=6&db=m The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27585998&form=6&db=m Solubility enhancement and targeted delivery of a potent anticancer flavonoid analogue to cancer cells using ligand decorated dendrimer nano-architectures. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602152&form=6&db=m Action of HMGB1 on miR-221/222 cluster in neuroblastoma cell lines. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27603005&form=6&db=m A multicenter, single-arm, open-label, phase 2 study of apitolisib (GDC-0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study). diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27672335&form=6&db=m The association of PTEN hypermethylation and breast cancer: a meta-analysis. causal interaction,ongoing research,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27709720&form=6&db=m Differential micro ribonucleic acid expression profiling in ovarian endometrioma with leuprolide acetate treatment. diagnostic usage,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27716613&form=6&db=m Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27746632&form=6&db=m Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27748775&form=6&db=m Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27765117&form=6&db=m [Research progress of suppressor gene PTEN]. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27797378&form=6&db=m Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27801993&form=6&db=m Predictive factors of the tumor immunological microenvironment for long-term follow-up in early stage breast cancer. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27840403&form=6&db=m MicroRNA-152 Targets Phosphatase and Tensin Homolog to Inhibit Apoptosis and Promote Cell Migration of Nasopharyngeal Carcinoma Cells. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27893783&form=6&db=m Role of PTEN in Oxidative Stress and DNA Damage in the Liver of Whole-Body Pten Haplodeficient Mice. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27932596&form=6&db=m Infantile Lhermitte-Duclos Disease Treated Successfully With Rapamycin. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27980214&form=6&db=m The ISG15-specific protease USP18 regulates stability of PTEN. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27986563&form=6&db=m Role and mechanism of PTEN in adiponectin-induced osteogenesis in human bone marrow mesenchymal stem cells. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994422&form=6&db=m Immunohistochemical expression of phosphatase and tensin homolog in histologic gradings of oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28019709&form=6&db=m Exogenous induction of unphosphorylated PTEN reduces TGF?-induced extracellular matrix expressions in lung fibroblasts. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28087729&form=6&db=m Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor ?-activated stem cells. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28092677&form=6&db=m WNT/?-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28106991&form=6&db=m Discovery of a Phosphoinositide 3-Kinase (PI3K) ?/? Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3K? Potency in a PI3K?-Selective Template by Targeting Nonconserved Asp856. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28124240&form=6&db=m Epigenetic Downregulation of PTEN in Gallbladder Cancer. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28140697&form=6&db=m PTEN and TRAIL genes loaded zein nanoparticles as potential therapy for hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193700&form=6&db=m The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28236692&form=6&db=m Synthesis and characterization of folate decorated albumin bio-conjugate nanoparticles loaded with a synthetic curcumin difluorinated analogue. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28251007&form=6&db=m A Pediatric Case of Cowden Syndrome with Graves' Disease. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28260104&form=6&db=m miR-92a promotes tumor growth of osteosarcoma by targeting PTEN/AKT signaling pathway. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28263037&form=6&db=m Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28339030&form=6&db=m Increased phosphorylation of 4E?binding protein 1 predicts poor prognosis for patients with colorectal cancer. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351303&form=6&db=m Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28358430&form=6&db=m Comparison of the PI3KCA pathway in circulating tumor cells and corresponding tumor tissue of patients with metastatic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28401059&form=6&db=m Bannayan-Riley-Ruvalcaba Syndrome in a Patient with a PTEN Mutation Identified by Chromosomal Microarray Analysis: A Case Report. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28401302&form=6&db=m Combinatorial therapy with adenoviral-mediated PTEN and a PI3K inhibitor suppresses malignant glioma cell growth in vitro and in vivo by regulating the PI3K/AKT signaling pathway. causal interaction,therapeutic application,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28437835&form=6&db=m PTEN Down-Regulation Promotes ?-Oxidation to Fuel Hypertrophic Liver Growth After Hepatectomy in Mice. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28439009&form=6&db=m Estrogen receptor ?, a regulator of androgen receptor signaling in the mouse ventral prostate. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474162&form=6&db=m [Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis]. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28475001&form=6&db=m MiR-19a regulates the cell growth and apoptosis of osteosarcoma stem cells by targeting PTEN. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28481871&form=6&db=m Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28529243&form=6&db=m Over-Expression of miR-21 and Lower PTEN Levels in Wilms' Tumor with Aggressive Behavior. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599463&form=6&db=m Cancer gene panel analysis of cultured circulating tumor cells and primary tumor tissue from patients with breast cancer. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28602818&form=6&db=m Cell Cycle Control by PTEN. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28603282&form=6&db=m The functions of tumor suppressor PTEN in innate and adaptive immunity. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28606050&form=6&db=m Insights into the targeting potential of thymoquinone for therapeutic intervention against triple-negative breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28608966&form=6&db=m Next-generation sequencing and clinical outcomes of patients with lung adenocarcinoma treated with stereotactic body radiotherapy. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28614300&form=6&db=m PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28623358&form=6&db=m The role of PTEN - HCV core interaction in hepatitis C virus replication. causal interaction,ongoing research,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28640831&form=6&db=m Ribosomal DNA copy number loss and sequence variation in cancer. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28658642&form=6&db=m Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28672019&form=6&db=m Phosphatase and tensin homolog (PTEN) expression on oncologic outcome in renal cell carcinoma: A systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28685087&form=6&db=m Heterogeneity in the colorectal primary tumor and the synchronous resected liver metastases prior to and after treatment with an anti-EGFR monoclonal antibody. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28686971&form=6&db=m GAS5 knockdown reduces the chemo-sensitivity of non-small cell lung cancer (NSCLC) cell to cisplatin (DDP) through regulating miR-21/PTEN axis. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714370&form=6&db=m Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28723560&form=6&db=m CRKL Mediates p110?-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28723738&form=6&db=m Phosphatase and tensin homolog (PTEN) is down-regulated in human NK/T-cell lymphoma and corrects with clinical outcomes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28766684&form=6&db=m Epigallocatechin-3-gallate promotes all-trans retinoic acid-induced maturation of acute promyelocytic leukemia cells via PTEN. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28771191&form=6&db=m Somatic Host Cell Alterations in HPV Carcinogenesis. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28774816&form=6&db=m Redox regulation of the tumor suppressor PTEN by the thioredoxin system and cumene hydroperoxide. diagnostic usage,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28779166&form=6&db=m The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28779187&form=6&db=m Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28783500&form=6&db=m Treatment with PTEN-Long protein inhibits hepatitis C virus replication. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804548&form=6&db=m Overexpression of PTEN suppresses non-small-cell lung carcinoma metastasis through inhibition of integrin ?V?6 signaling. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808481&form=6&db=m Cul4B is a novel prognostic marker in cholangiocarcinoma. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28823542&form=6&db=m The tumor suppressor phosphatase and tensin homolog protein (PTEN) is negatively regulated by NF-?b p50 homodimers and involves histone 3 methylation/deacetylation in UROtsa cells chronically exposed to monomethylarsonous acid. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28847996&form=6&db=m Multiple sclerotic fibromas of the skin: an important clue for the diagnosis of Cowden syndrome. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28848709&form=6&db=m New Treatment Opportunities in Phosphatase and Tensin Homolog (PTEN)-Deficient Tumors: Focus on PTEN/Focal Adhesion Kinase Pathway. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28874658&form=6&db=m Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer. diagnostic usage,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28886696&form=6&db=m Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28891094&form=6&db=m Regulation of the tumor suppressor PTEN by natural anticancer compounds. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927044&form=6&db=m Isolation and characterization of adult mammary stem cells from breast cancer-adjacent tissues. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28928809&form=6&db=m NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28929017&form=6&db=m Calcitonin receptor expression in medullary thyroid carcinoma. causal interaction,diagnostic usage,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28941804&form=6&db=m MiR-132 promotes the proliferation, invasion and migration of human pancreatic carcinoma by inhibition of the tumor suppressor gene PTEN. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28942103&form=6&db=m Antagonist of thromboxane A2 receptor by SQ29548 lowers DOCA-induced hypertension in diabetic rats. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28943948&form=6&db=m Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28945226&form=6&db=m PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28945300&form=6&db=m Upregulation of pAKT(Ser473) expression is involved in progression of HPV-positive oropharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28951314&form=6&db=m Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28976556&form=6&db=m First-in-human trial of the PI3K?-selective inhibitor SAR260301 in patients with advanced solid tumors. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28982865&form=6&db=m Deregulation of PTEN Expression in Laryngeal Squamous Cell Carcinoma Based on Tissue Microarray Digital Analysis. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29021651&form=6&db=m MicroRNA-21 could be a molecular marker to predict the recurrence of nonmuscle invasive bladder cancer. causal interaction,ongoing research,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29057971&form=6&db=m PTEN-L promotes type I interferon responses and antiviral immunity. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29085498&form=6&db=m Downregulation of MACC1 inhibits the viability, invasion and migration and induces apoptosis in esophageal carcinoma cells through the phosphatase and tensin homolog/phosphoinositide 3-kinase/protein kinase B signaling pathway. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088815&form=6&db=m Radiation-resistant cancer stem-like cell properties are regulated by PTEN through the activity of nuclear ?-catenin in nasopharyngeal carcinoma. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29141684&form=6&db=m Bioinformatics prediction of miR-30a targets and its inhibition of cell proliferation of osteosarcoma by up-regulating the expression of PTEN. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29160937&form=6&db=m MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29175021&form=6&db=m PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29221206&form=6&db=m Single nucleotide polymorphisms rs701848 and rs2735343 in PTEN increases cancer risks in an Asian population. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228234&form=6&db=m Tgfbr2 inactivation facilitates cellular plasticity and development of Pten-null prostate cancer. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29230689&form=6&db=m The combination of curcumin and 5-fluorouracil in cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262553&form=6&db=m Inhibition of PTEN activity aggravates cisplatin-induced acute kidney injury. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29283497&form=6&db=m Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29385181&form=6&db=m Simvastatin and metformin inhibit cell growth in hepatitis C virus infected cells via mTOR increasing PTEN and autophagy. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29393355&form=6&db=m miR?21?5p confers doxorubicin resistance in gastric cancer cells by targeting PTEN and TIMP3. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399165&form=6&db=m Phosphorylation of phosphatase and tensin homolog induced by causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408173&form=6&db=m PTEN in kidney cancer: A review and meta-analysis. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434898&form=6&db=m ABT-737 and pictilisib synergistically enhance pitavastatin-induced apoptosis in ovarian cancer cells. therapeutic application,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29435055&form=6&db=m Interference of P-REX2a may inhibit proliferation and reverse the resistance of SGC7901 cells to doxorubicin. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29455665&form=6&db=m PTEN/PTENP1: 'Regulating the regulator of RTK-dependent PI3K/Akt signalling', new targets for cancer therapy. therapeutic application,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29460925&form=6&db=m Clinical implications of PTEN loss in prostate cancer. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29463194&form=6&db=m The Expression and Prognostic Impact of the PI3K/AKT/mTOR Signaling Pathway in Advanced Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29488607&form=6&db=m The expression of microRNA-23a regulates acute myocardial infarction in patients and in vitro through targeting PTEN. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29562639&form=6&db=m New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29566768&form=6&db=m Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29568880&form=6&db=m Simvastatin induces apoptosis in PTEN?haploinsufficient lipoma cells. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29578164&form=6&db=m Phosphatase and tensin homolog protein may be linked to lymph node metastasis and tumor node metastasis staging in nonsmall cell lung cancer. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29599344&form=6&db=m Racial Disparities in the Molecular Landscape of Cancer. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663862&form=6&db=m Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29666622&form=6&db=m Chemotactic Cues for NOTCH1-Dependent Leukemia. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29685889&form=6&db=m WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29706350&form=6&db=m A Saturation Mutagenesis Approach to Understanding PTEN Lipid Phosphatase Activity and Genotype-Phenotype Relationships. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29720545&form=6&db=m Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29723979&form=6&db=m Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29724044&form=6&db=m Mechanisms of Intrinsic Tumor Resistance to Immunotherapy. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29735527&form=6&db=m Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29780388&form=6&db=m Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29803738&form=6&db=m An important role of SREBP-1 in HBV and HCV co-replication inhibition by PTEN. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805503&form=6&db=m Long non-coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3-kinase/protein kinase B signaling pathway. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858080&form=6&db=m Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29868481&form=6&db=m Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872713&form=6&db=m Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29916735&form=6&db=m MicroRNA-1297 contributes to the progression of human cervical carcinoma through PTEN. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29963139&form=6&db=m miR-142 suppresses proliferation and induces apoptosis of osteosarcoma cells by upregulating Rb. diagnostic usage,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29985991&form=6&db=m MicroRNA-498 promotes proliferation and migration by targeting the tumor suppressor PTEN in breast cancer cells. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30009155&form=6&db=m Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss? causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30053103&form=6&db=m Alternative polyadenylation confers Pten mRNAs stability and resistance to microRNAs. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30094405&form=6&db=m A Survey of Molecular Heterogeneity in Hepatocellular Carcinoma. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30111295&form=6&db=m First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30120912&form=6&db=m Targeted sequencing and intracranial outcomes of patients with lung adenocarcinoma brain metastases treated with radiotherapy. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30134988&form=6&db=m PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30154635&form=6&db=m Temporal Evolution and Management of Fast Flow Vascular Anomalies in PTEN Hamartoma Tumor Syndrome. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30160042&form=6&db=m Novel therapeutic roles of MC-4 in combination with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of rapamycin complex 1 pathways. causal interaction,therapeutic application,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30165041&form=6&db=m Pten Haplodeficiency Accelerates Liver Tumor Growth in miR-122a-Null Mice via Expansion of Periportal Hepatocyte-Like Cells. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30181177&form=6&db=m Treg Destabilization and Reprogramming: Implications for Cancer Immunotherapy. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30214545&form=6&db=m Hsa_circ_0033155: A potential novel biomarker for non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30217221&form=6&db=m Regulation of PTEN expression by noncoding RNAs. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30221716&form=6&db=m miRNA?328 overexpression confers cisplatin resistance in non?small cell lung cancer via targeting of PTEN. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30226608&form=6&db=m Generation of PTEN?knockout (?/?) murine prostate cancer cells using the CRISPR/Cas9 system and comprehensive gene expression profiling. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30246429&form=6&db=m Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30262665&form=6&db=m Protein phosphatase 5 and the tumor suppressor P53 down-regulate each other's activities in mice. causal interaction,ongoing research,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30275180&form=6&db=m Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30289966&form=6&db=m Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30290714&form=6&db=m PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30316882&form=6&db=m Variable expressivity and novel PTEN mutations in Cowden syndrome. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30365133&form=6&db=m MicroRNA?494 promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of rapamycin pathway by phosphatase and tensin homolog expression. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30372795&form=6&db=m PTEN and miR-26b: Promising prognostic biomarkers in initiation and progression of Oral Squamous Cell Carcinoma. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30405802&form=6&db=m Association of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30447426&form=6&db=m Retinal astrocytoma in a young male with PTEN hamartoma tumor syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30471096&form=6&db=m Roles of phosphatase and tensin homolog in skeletal muscle. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30479334&form=6&db=m PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30483877&form=6&db=m The role of PI3K/AKT/FOXO signaling in psoriasis. causal interaction,ongoing research,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30511743&form=6&db=m Loss of PTEN expression as diagnostic marker of endometrial precancer: A systematic review and meta-analysis. diagnostic usage,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30513611&form=6&db=m A Soft Coral-Derived Compound, 11-Dehydrosinulariolide, Induces G2/M Cell Cycle Arrest and Apoptosis in Small Cell Lung Cancer. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30530687&form=6&db=m Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30542737&form=6&db=m Pectolinarigenin inhibits non?small cell lung cancer progression by regulating the PTEN/PI3K/AKT signaling pathway. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30546421&form=6&db=m Novel insight into the function of tankyrase. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30569117&form=6&db=m PTEN downregulates WD repeat?containing protein 66 in salivary adenoid cystic carcinoma. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30575166&form=6&db=m A case of follicular thyroid carcinoma associated with phosphatase and tensin homologue hamartoma tumour syndrome. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30614812&form=6&db=m PTEN-opathies: from biological insights to evidence-based precision medicine. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30616477&form=6&db=m Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30623366&form=6&db=m Targeting PTEN in Colorectal Cancers. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30649986&form=6&db=m SIRT4 regulates PTEN stability through IDE in response to cellular stresses. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651843&form=6&db=m Differential expression of long non-coding RNA and mRNA in children with Henoch-Schönlein purpura nephritis. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655739&form=6&db=m A clinical study on the expression of PTEN in renal cell carcinoma in children. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30655903&form=6&db=m PTEN inhibits non-small cell lung cancer cell growth by promoting G0/G1 arrest and cell apoptosis. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30688935&form=6&db=m Ear atresia: Is there a role of apoptosis-regulating miRNAs? causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30697739&form=6&db=m miR-545 promoted enterovirus 71 replication via directly targeting phosphatase and tensin homolog and tumor necrosis factor receptor-associated factor 6. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30722993&form=6&db=m GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30738963&form=6&db=m Single nucleotide polymorphism in PTEN-Long gene: A risk factor in chronic myeloid leukemia. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30775814&form=6&db=m Overexpression of UBR5 promotes tumor growth in gallbladder cancer via PTEN/PI3K/Akt signal pathway. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30781847&form=6&db=m Differential Methylation and Acetylation as the Epigenetic Basis of Resveratrol's Anticancer Activity. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30799775&form=6&db=m Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30819264&form=6&db=m PTEN influences insulin and lipid metabolism in bovine hepatocytes in vitro. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30841886&form=6&db=m Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30849479&form=6&db=m Long noncoding RNA Linc02023 regulates PTEN stability and suppresses tumorigenesis of colorectal cancer in a PTEN-dependent pathway. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30867411&form=6&db=m The LXR-623-induced long non-coding RNA LINC01125 suppresses the proliferation of breast cancer cells via PTEN/AKT/p53 signaling pathway. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30867798&form=6&db=m Molecular association of functioning stroma with carcinoma cells in the ovary: A preliminary study. diagnostic usage,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30901475&form=6&db=m Serum Biomarkers for Racial Disparities in Breast Cancer Progression. causal interaction,diagnostic usage,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30925702&form=6&db=m PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise? causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30938910&form=6&db=m Activation of the oncogenic miR-21-5p promotes HCV replication and steatosis induced by the viral core 3a protein. therapeutic application,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30942445&form=6&db=m Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30970626&form=6&db=m Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30977354&form=6&db=m Interleukin-1?/nuclear factor-?B signaling promotes osteosarcoma cell growth through the microRNA-181b/phosphatase and tensin homolog axis. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30999672&form=6&db=m The PTEN?PI3K Axis in Cancer. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31002157&form=6&db=m Over-expression of DJ-1 attenuates effects of curcumin on colorectal cancer cell proliferation and apoptosis. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015614&form=6&db=m Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31024258&form=6&db=m Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31033083&form=6&db=m LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR-641/PTEN axis. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31036466&form=6&db=m Metastatic Chromophobe Renal Cell Carcinoma: Presence or Absence of Sarcomatoid Differentiation Determines Clinical Course and Treatment Outcomes. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31059004&form=6&db=m Class I histone deacetylase inhibitor suppresses vasculogenic mimicry by enhancing the expression of tumor suppressor and anti-angiogenesis genes in aggressive human TNBC cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31074088&form=6&db=m The CtBP1-p300-FOXO3a transcriptional complex represses the expression of the apoptotic regulators Bax and Bim in human osteosarcoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31074114&form=6&db=m Assessment of epigenetic alterations and in silico analysis of mutation affecting PTEN expression among Indian cervical cancer patients. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31074594&form=6&db=m MicroRNA-4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non-small cell lung cancer. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31075299&form=6&db=m PTEN and ERG detection in multiparametric magnetic resonance imaging/ultrasound fusion targeted prostate biopsy compared to systematic biopsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31090947&form=6&db=m Promotion of PTEN on apoptosis through PI3K/Akt signal in vascular smooth muscle cells of mice model of coronary heart disease. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31107726&form=6&db=m Clinical and Histologic Overlap and Distinction Among Various Hamartomatous Polyposis Syndromes. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31126975&form=6&db=m Genetic alterations and expression of PTEN and its relationship with cancer stem cell markers to investigate pathogenesis and to evaluate prognosis in hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31149344&form=6&db=m A novel missense PTEN mutation identified in a patient with macrocephaly and developmental delay. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31151317&form=6&db=m Targeting Angiogenesis in Prostate Cancer. causal interaction,diagnostic usage,unassigned 3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31169889&form=6&db=m PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186785&form=6&db=m Expression and significance of PTEN and Claudin-3 in prostate cancer. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31206626&form=6&db=m Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31216739&form=6&db=m PTEN Hamartoma Tumor Syndrome: A Clinical Overview. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217901&form=6&db=m PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31240311&form=6&db=m PTEN Activity Defines an Axis for Plasticity at Cortico-Amygdala Synapses and Influences Social Behavior. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31257492&form=6&db=m RSRC1 suppresses gastric cancer cell proliferation and migration by regulating PTEN expression. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31270271&form=6&db=m CFTR-PTEN-dependent mitochondrial metabolic dysfunction promotes Pseudomonas aeruginosa airway infection. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291551&form=6&db=m PTEN? regulates endocytosis and modulates olfactory function. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31320611&form=6&db=m Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31349190&form=6&db=m Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31352310&form=6&db=m Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366089&form=6&db=m PTEN Tumor-Suppressor: The Dam of Stemness in Cancer. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31404976&form=6&db=m PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31416195&form=6&db=m The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31421682&form=6&db=m MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423236&form=6&db=m ILF2 promotes anchorage independence through direct regulation of PTEN. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427284&form=6&db=m PTEN in Autism and Neurodevelopmental Disorders. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427286&form=6&db=m PTEN in the Stroma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31434417&form=6&db=m [Phosphatase and tensin homolog deleted on chromosome ten deficiency sensitizes tumor cells to lithium chloride treatment]. ongoing research,therapeutic application,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31451538&form=6&db=m The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31452757&form=6&db=m Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31452834&form=6&db=m V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31454965&form=6&db=m Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31461649&form=6&db=m Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31485618&form=6&db=m Clofarabine?phytochemical combination exposures in CML cells inhibit DNA methylation machinery, upregulate tumor suppressor genes and promote caspase?dependent apoptosis. diagnostic usage,ongoing research,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31489901&form=6&db=m Gentamicin Targets Acid Sphingomyelinase in Cancer: The Case of the Human Gastric Cancer NCI-N87 Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31500630&form=6&db=m Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,4 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31546901&form=6&db=m Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31564201&form=6&db=m Down-regulated lncRNA TP73-AS1 reduces radioresistance in hepatocellular carcinoma via the PTEN/Akt signaling pathway. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31570378&form=6&db=m PTEN in Hereditary and Sporadic Cancer. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31570383&form=6&db=m PTEN Mouse Models of Cancer Initiation and Progression. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31595691&form=6&db=m In vivo longitudinal imaging of RNA interference-induced endocrine therapy resistance in breast cancer. diagnostic usage,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31602239&form=6&db=m Effect and mechanism of microRNA-10b on proliferation and invasion of esophageal cancer cells. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31635307&form=6&db=m ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85? Deficient Cancer Cells and Influence Platinum Sensitivity. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31636093&form=6&db=m Structural Mechanisms of PTEN Regulation. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31663655&form=6&db=m PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31664643&form=6&db=m Allopregnanolone Reverses Bioenergetic Deficits in Female Triple Transgenic Alzheimer's Mouse Model. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31767180&form=6&db=m Adipose PTEN regulates adult adipose tissue homeostasis and redistribution via a PTEN-leptin-sympathetic loop. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31812062&form=6&db=m Exosomes derived from normal human bronchial epithelial cells down-regulate proliferation and migration of hydroquinone-transformed malignant recipient cells via up-regulating PTEN expression. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31841199&form=6&db=m PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31844155&form=6&db=m Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31871240&form=6&db=m The Complex Landscape of PTEN mRNA Regulation. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31871924&form=6&db=m Long Noncoding RNA GATA3-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Suppression of PTEN, CDKN1A, and TP53. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31896494&form=6&db=m Up-regulation of PTEN via LPS/AP-1/NF-?B pathway inhibits trophoblast invasion contributing to preeclampsia. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31914691&form=6&db=m PTEN deletion drives aberrations of DNA methylome and transcriptome in different stages of prostate cancer. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31927175&form=6&db=m Imaging of PTEN-related abnormalities in the central nervous system. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31931659&form=6&db=m Autophagy drives fibroblast senescence through MTORC2 regulation. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31932468&form=6&db=m Posttranslational Regulation and Conformational Plasticity of PTEN. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31955800&form=6&db=m Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31966631&form=6&db=m MicroRNA-590-5p promotes cell survival in endometrioid endometrial cancer by suppressing tumor suppressor PTEN. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32016465&form=6&db=m Low?intensity ultrasound enhances the antitumor effects of doxorubicin on hepatocellular carcinoma cells through the ROS?miR?21?PTEN axis. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32037610&form=6&db=m Phosphatase and tensin homolog deletion enhances neurite outgrowth during neural stem cell differentiation. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32089060&form=6&db=m Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32098071&form=6&db=m PTEN Expression as a Complementary Biomarker for Mismatch Repair Testing in Breast Cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32101951&form=6&db=m LncRNA cancer susceptibility candidate (CASC7) upregulates phosphatase and tensin homolog by downregulating miR-10a to inhibit neuroblastoma cell proliferation. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32134893&form=6&db=m Investigation of PTEN promoter methylation in ameloblastoma. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32146564&form=6&db=m MicroRNAs that regulate PTEN as potential biomarkers in colorectal cancer: a systematic review. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32150281&form=6&db=m Loss of the adhesion molecule CEACAM1 is associated with early biochemical recurrence in TMPRSS2:ERG fusion-positive prostate cancers. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32160093&form=6&db=m Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32162714&form=6&db=m Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer. causal interaction,diagnostic usage,unassigned 1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32202193&form=6&db=m Ursodeoxycholic acid inhibits intimal hyperplasia, vascular smooth muscle cell excessive proliferation, migration via blocking miR-21/PTEN/AKT/mTOR signaling pathway. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32228695&form=6&db=m PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32278045&form=6&db=m The anticancer effects of curcumin via targeting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32295169&form=6&db=m Clinical Value of lncRNA MEG3 in High-Grade Serous Ovarian Cancer. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32306805&form=6&db=m Perspectives on the role of PTEN in diabetic nephropathy: an update. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32355326&form=6&db=m The diverse roles of SPOP in prostate cancer and kidney cancer. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32393046&form=6&db=m The expression of microRNAs and exposure to environmental contaminants related to human health: a review. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32394474&form=6&db=m HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32401642&form=6&db=m Autophagy in the physiological endometrium and cancer. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459922&form=6&db=m WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. causal interaction,diagnostic usage,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32467227&form=6&db=m Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32479694&form=6&db=m Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485246&form=6&db=m PTEN: What we know of the function and regulation of this onco-suppressor factor in bladder cancer? causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32509304&form=6&db=m Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review). unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32512654&form=6&db=m Comprehensive Analysis of PTEN in Primary Cutaneous Melanoma. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32532965&form=6&db=m Regulating tumor suppressor genes: post-translational modifications. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32546428&form=6&db=m Loss of PTEN sensitizes head and neck squamous cell carcinoma to 5-AZA-2'-deoxycytidine. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32588888&form=6&db=m Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32605290&form=6&db=m PTEN Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine? causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32610572&form=6&db=m PTEN Protein Loss and Loss-of-Function Mutations in Gastric Cancers: The Relationship with Microsatellite Instability, EBV, HER2, and PD-L1 Expression. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32626930&form=6&db=m The long non?coding RNA CASC7 inhibits growth and invasion of non?small cell lung cancer cells through phosphatase and tensin homolog upregulation via sequestration of miR?92a. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32634262&form=6&db=m PTEN and ERG expression in MRI-ultrasound guided fusion biopsy correlated with radical prostatectomy findings in men with prostate cancer. diagnostic usage,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32689721&form=6&db=m Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome: A Case Report. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32708484&form=6&db=m The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32724440&form=6&db=m miR-494 promotes progression of retinoblastoma via PTEN through PI3K/AKT signaling pathway. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32727102&form=6&db=m PTEN Function at the Interface between Cancer and Tumor Microenvironment: Implications for Response to Immunotherapy. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32727251&form=6&db=m Transcriptomic Profiling of Circulating HLA-DR- Myeloid Cells, Compared with HLA-DR+ Myeloid Antigen-presenting Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32737433&form=6&db=m Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32765849&form=6&db=m Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review). diagnostic usage,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32765873&form=6&db=m Molecular analysis of circulating tumor DNA from breast cancer patients before and after surgery and following adjuvant chemotherapy. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32795117&form=6&db=m First Molecular Genetic Characterization of Skene's Gland Adenocarcinoma. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32806051&form=6&db=m Translational Nanomedicine Boosts Anti-PD1 Therapy to Eradicate Orthotopic PTEN-Negative Glioblastoma. causal interaction,ongoing research,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32815783&form=6&db=m Mediastinal Germ Cell Tumor and Acute Megakaryoblastic Leukemia With Co-occurring KRAS Mutation and Complex Cytogenetics. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32827577&form=6&db=m PTEN in osteosarcoma: Recent advances and the therapeutic potential. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32901863&form=6&db=m Piceatannol suppresses proliferation and induces apoptosis by regulation of the microRNA?21/phosphatase and tensin homolog/protein kinase B signaling pathway in osteosarcoma cells. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32959108&form=6&db=m Upregulation of DJ-1 expression in melanoma regulates PTEN/AKT pathway for cell survival and migration. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32972352&form=6&db=m Clinical and In Silico Outcomes of miR-130a-5p and miR-615-3p Expression in Tumor Compared with Non-Tumor Adjacent Tissues of Patients with BC. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32988862&form=6&db=m Genomic Database Analysis for Head and Neck Cancer Prevention Targets: MTOR Signal Transduction Pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33000006&form=6&db=m Genetic Landscape of Prostate Cancer Conspicuity on Multiparametric Magnetic Resonance Imaging: A Systematic Review and Bioinformatic Analysis. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33003585&form=6&db=m Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33034258&form=6&db=m In silico approach of naringin as potent phosphatase and tensin homolog (PTEN) protein agonist against prostate cancer. diagnostic usage,therapeutic application,unassigned 2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33036164&form=6&db=m Identifying Differentially Expressed MicroRNAs, Target Genes, and Key Pathways Deregulated in Patients with Liver Diseases. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33042620&form=6&db=m SLFN5 influences proliferation and apoptosis by upregulating PTEN transcription via ZEB1 and inhibits the purine metabolic pathway in breast cancer. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33068545&form=6&db=m PTEN Inhibition Ameliorates Muscle Degeneration and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33074689&form=6&db=m Approaches to Investigating the Protein Interactome of PTEN. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33094056&form=6&db=m A Rare Case of Atypical Pleomorphic Neoplasm of Pineal Region in a Child: A Case Report. diagnostic usage,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33103467&form=6&db=m Thidiazuron suppresses breast cancer progression via targeting miR-132 and miR-202-5p/PTEN axis mediated dysregulation of PI3K/AKT signaling pathway. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33105713&form=6&db=m The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112833&form=6&db=m From adrenarche to aging of adrenal zona reticularis: precocious female adrenopause onset. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33154957&form=6&db=m miR-3 Encoded by Hepatitis B Virus Downregulates PTEN Protein Expression and Promotes Cell Proliferation. causal interaction,diagnostic usage,unassigned 3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33166764&form=6&db=m Regulatory role of microRNAs on PTEN signaling. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33194618&form=6&db=m TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT-GSK-3?-?-Catenin Signaling Pathway. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33229547&form=6&db=m Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis. causal interaction,ongoing research,unassigned 1,3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33332075&form=6&db=m Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347611&form=6&db=m Revisiting the Warburg effect: historical dogma versus current understanding. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33444287&form=6&db=m Concerted roles of PTEN and ATM in controlling hematopoietic stem cell fitness and dormancy. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33448321&form=6&db=m Downregulation of microRNA?25?3p inhibits the proliferation and promotes the apoptosis of multiple myeloma cells via targeting the PTEN/PI3K/AKT signaling pathway. causal interaction,ongoing research,unassigned 2,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33540467&form=6&db=m PTEN is required for the migration and invasion of Ras-transformed MDCK cells. ongoing research,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33618627&form=6&db=m The roles of microbial products in the development of colorectal cancer: a review. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33669370&form=6&db=m Redox Regulation of PTEN by Peroxiredoxins. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33670518&form=6&db=m Small in Size, but Large in Action: microRNAs as Potential Modulators of PTEN in Breast and Lung Cancers. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33686550&form=6&db=m MiR-6838-5p facilitates the proliferation and invasion of renal cell carcinoma cells through inhibiting the DMTF1/ARF-p53 axis. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33708847&form=6&db=m DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33724154&form=6&db=m Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33741170&form=6&db=m Phosphatase and tensin homolog (PTEN) suppresses triacylglycerol accumulation and monounsaturated fatty acid synthesis in goat mammary epithelial cells. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33821441&form=6&db=m Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33822054&form=6&db=m mTOR inhibitors reduce enteropathy, intestinal bleeding and colectomy rate in patients with juvenile polyposis of infancy with PTEN-BMPR1A deletion. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33874915&form=6&db=m PTEN loss correlates with T cell exclusion across human cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33887726&form=6&db=m The Clinical Spectrum of PTEN Hamartoma Tumor Syndrome: Exploring the Value of Thyroid Surveillance. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33904341&form=6&db=m The influence of circular RNAs on autophagy and disease progression. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33957633&form=6&db=m BRCA1 Protein Expression Predicts Survival in Glioblastoma Patients from an NRG Oncology RTOG Cohort. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33970384&form=6&db=m Clinical impact of PTEN methylation status as a prognostic marker for breast cancer. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055067&form=6&db=m Silencing miRNA-1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34140896&form=6&db=m Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34162754&form=6&db=m Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34165715&form=6&db=m Studying the Oncosuppressive Functions of PTENP1 as a ceRNA. unassigned - 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179044&form=6&db=m The Skin in Cowden Syndrome. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34231499&form=6&db=m Endoscopic Findings in Patients With PTEN Hamartoma Tumor Syndrome Undergoing Surveillance. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34242625&form=6&db=m PTEN protects kidney against acute kidney injury by alleviating apoptosis and promoting autophagy via regulating HIF1-? and mTOR through PI3K/Akt pathway. causal interaction,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249684&form=6&db=m LINC00470 Stimulates Methylation of PTEN to Facilitate the Progression of Endometrial Cancer by Recruiting DNMT3a Through MYC. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34268892&form=6&db=m Prevalence and clinical/molecular characteristics of PTEN mutations in Turkish children with autism spectrum disorders and macrocephaly. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34273354&form=6&db=m PTEN regulates adipose progenitor cell growth, differentiation, and replicative aging. causal interaction,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34295560&form=6&db=m DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway. ongoing research,unassigned 2,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34319509&form=6&db=m Glioblastoma Therapy: Rationale for a Mesenchymal Stem Cell-based Vehicle to Carry Recombinant Viruses. causal interaction,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34331820&form=6&db=m Rapamycin promotes autophagy cell death of Kaposi's sarcoma cells through P75NTR activation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34358959&form=6&db=m Tissue distribution and developmental changes of PTEN in the immune organs of chicken and effect of IBDV infection on it. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34370147&form=6&db=m Synergistic effects of Rapamycin and Fluorouracil to treat a gastric tumor in a PTEN conditional deletion mouse model. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34397726&form=6&db=m Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407056&form=6&db=m Long noncoding RNA ALOX12-AS1 inhibits cervical cancer cells proliferation via targeting miR-3171. ongoing research,unassigned 4,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34447682&form=6&db=m Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34453780&form=6&db=m RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR with miR-92a-3p. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 3.1.3.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34523696&form=6&db=m Targeting the mTOR pathway using novel ATP?competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma. causal interaction,unassigned 4,0 3.1.3.67 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22110200&form=6&db=m Differential Akt signalling in non-seminomatous testicular germ cell tumors. therapeutic application,unassigned 1,0 3.1.3.67 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124605&form=6&db=m miRNA-1297 induces cell proliferation by targeting phosphatase and tensin homolog in testicular germ cell tumor cells. ongoing research,unassigned 3,0 3.1.3.67 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110043&form=6&db=m Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2 3.1.3.67 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30680021&form=6&db=m Expression of PTEN-long nephritis and its effect on renal inflammation. ongoing research,unassigned 3,0 3.1.3.67 Nerve Sheath Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22700876&form=6&db=m PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. unassigned - 3.1.3.67 Nerve Sheath Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23319880&form=6&db=m Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29735527&form=6&db=m Nuclear PTEN deficiency causes microcephaly with decreased neuronal soma size and increased seizure susceptibility. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Nervous System Malformations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27543776&form=6&db=m Lhermitte-Duclos disease with neurofibrillary tangles in heterotopic cerebral grey matter. causal interaction,unassigned 4,0 3.1.3.67 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25889774&form=6&db=m Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain. ongoing research,therapeutic application,unassigned 1,1,0 3.1.3.67 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21892205&form=6&db=m Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22281088&form=6&db=m Clinicopathologic and Molecular Analysis of a Choroidal Pigmented Schwannoma in the Context of a PTEN Hamartoma Tumor Syndrome. causal interaction,unassigned 2,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11369059&form=6&db=m Analysis of PTEN/MMAC1 alteration in neuroblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11457734&form=6&db=m PTEN/MMAC1 overexpression decreases insulin-like growth factor-I-mediated protection from apoptosis in neuroblastoma cells. ongoing research,unassigned 2,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16417231&form=6&db=m Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17894887&form=6&db=m OncomiRs: the discovery and progress of microRNAs in cancers. therapeutic application,unassigned 1,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21641013&form=6&db=m Activation of the phosphatidylinositol 3'-kinase/AKT pathway in neuroblastoma and its regulation by thioredoxin 1. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21719054&form=6&db=m Integrin-linked kinase regulates phosphatase and tensin homologue activity to promote tumorigenesis in neuroblastoma cells. therapeutic application,unassigned 1,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22511720&form=6&db=m Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis. causal interaction,unassigned 2,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24823994&form=6&db=m Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27492819&form=6&db=m Suppression of miR-19b enhanced the cytotoxic effects of mTOR inhibitors in human neuroblastoma cells. causal interaction,unassigned 1,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28685087&form=6&db=m Heterogeneity in the colorectal primary tumor and the synchronous resected liver metastases prior to and after treatment with an anti-EGFR monoclonal antibody. unassigned - 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28951314&form=6&db=m Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. ongoing research,unassigned 2,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30275180&form=6&db=m Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30722993&form=6&db=m GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32101951&form=6&db=m LncRNA cancer susceptibility candidate (CASC7) upregulates phosphatase and tensin homolog by downregulating miR-10a to inhibit neuroblastoma cell proliferation. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30611996&form=6&db=m A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 3.1.3.67 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32236736&form=6&db=m PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy. causal interaction,unassigned 3,0 3.1.3.67 Neuroectodermal Tumors, Primitive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228674&form=6&db=m The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2 3.1.3.67 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23686804&form=6&db=m Expression of PTEN and mTOR in pancreatic neuroendocrine tumors. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29228674&form=6&db=m The regulatory role of aberrant Phosphatase and Tensin Homologue and Liver Kinase B1 on AKT/mTOR/c-Myc axis in pancreatic neuroendocrine tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2 3.1.3.67 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30373859&form=6&db=m Loss of PTEN and Increased pAKT Expression Distinguishes Aggressive Low-grade Neuroendocrine Tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 3.1.3.67 Neurofibromatoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578218&form=6&db=m Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. causal interaction,unassigned 4,0 3.1.3.67 Neurofibromatoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23556055&form=6&db=m Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome. causal interaction,unassigned 4,0 3.1.3.67 Neurofibromatoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30478082&form=6&db=m Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation. ongoing research,unassigned 4,0 3.1.3.67 Neurofibromatoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31206626&form=6&db=m Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Neurofibromatosis 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578218&form=6&db=m Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. causal interaction,unassigned 4,0 3.1.3.67 Neurofibromatosis 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22700876&form=6&db=m PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. unassigned - 3.1.3.67 Neurofibromatosis 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23556055&form=6&db=m Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome. causal interaction,unassigned 4,0 3.1.3.67 Neurofibromatosis 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468183&form=6&db=m Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism. causal interaction,unassigned 3,0 3.1.3.67 Neurofibromatosis 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27071790&form=6&db=m mTOR, a Potential Target to Treat Autism Spectrum Disorder. causal interaction,unassigned 2,0 3.1.3.67 Neurofibromatosis 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30478082&form=6&db=m Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation. ongoing research,unassigned 4,0 3.1.3.67 Neurofibromatosis 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31206626&form=6&db=m Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31448245&form=6&db=m Modulation of Type-I Interferon Response by hsa-miR-374b-5p During Japanese Encephalitis Virus Infection in Human Microglial Cells. therapeutic application,unassigned 1,0 3.1.3.67 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34166762&form=6&db=m Phosphatase and Tensin Homolog Deleted on Chromosome Ten Knockdown Attenuates Cognitive Deficits by Inhibiting Neuroinflammation in a Mouse Model of Perioperative Neurocognitive Disorder. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Neuroma, Acoustic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20856158&form=6&db=m MicroRNA-21 Overexpression Contributes to Vestibular Schwannoma Cell Proliferation and Survival. causal interaction,unassigned 4,0 3.1.3.67 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16146807&form=6&db=m Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 3.1.3.67 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20956280&form=6&db=m Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.3.67 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27746632&form=6&db=m Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1 3.1.3.67 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28779187&form=6&db=m Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations. causal interaction,unassigned 3,0 3.1.3.67 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30844349&form=6&db=m Congenital Limb Overgrowth Syndromes Associated with Vascular Anomalies. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Nevus, Pigmented http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12454773&form=6&db=m PTEN/MMAC1 expression in melanoma resection specimens. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 3.1.3.67 Nijmegen Breakage Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30799775&form=6&db=m Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population. diagnostic usage,unassigned 3,0 3.1.3.67 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24966582&form=6&db=m Pathogenesis and significance of hepatitis C virus steatosis: an update on survival strategy of a successful pathogen. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26820774&form=6&db=m Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice. ongoing research,unassigned 4,0 3.1.3.67 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794741&form=6&db=m The ménage à trois of autophagy, lipid droplets and liver disease. ongoing research,unassigned 2,0 3.1.3.67 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33199895&form=6&db=m The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1 3.1.3.67 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34234788&form=6&db=m Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice. unassigned - 3.1.3.67 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10231401&form=6&db=m Molecular genetic analysis of non-astrocytic gliomas. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 3.1.3.67 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701277&form=6&db=m Mechanisms of action of rapamycin in gliomas. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 3.1.3.67 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21804542&form=6&db=m Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. causal interaction,unassigned 3,0 3.1.3.67 Optic Atrophy, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28698153&form=6&db=m Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic. unassigned - 3.1.3.67 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24664767&form=6&db=m Nipradilol Promotes Axon Regeneration Through S-Nitrosylation of PTEN in Retinal Ganglion Cells. causal interaction,unassigned 4,0 3.1.3.67 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26005861&form=6&db=m Viral vector-based improvement of optic nerve regeneration: characterization of individual axons' growth patterns and synaptogenesis in a visual target. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33457476&form=6&db=m Lipidomics dataset of PTEN deletion-induced optic nerve regeneration mouse model. unassigned - 3.1.3.67 Oral Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25170002&form=6&db=m Oral manifestations of phosphatase and tensin homolog hamartoma tumor syndrome: a report of three cases. causal interaction,unassigned 3,0 3.1.3.67 Oral Submucous Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33959238&form=6&db=m PTEN and ?-SMA Expression and Diagnostic Role in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with Concomitant Oral Submucous Fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18704985&form=6&db=m Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310480&form=6&db=m MicroRNA-214 regulates osteosarcoma survival and growth by directly targeting phosphatase and tensin homolog. unassigned - 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28475001&form=6&db=m MiR-19a regulates the cell growth and apoptosis of osteosarcoma stem cells by targeting PTEN. causal interaction,unassigned 1,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29151913&form=6&db=m Expression of NF-?B and PTEN in osteosarcoma and its clinical significance. causal interaction,ongoing research,unassigned 2,2,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29412697&form=6&db=m miR-155 Affects Osteosarcoma MG-63 Cell Autophagy Induced by Adriamycin Through Regulating PTEN-PI3K/AKT/mTOR Signaling Pathway. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29496690&form=6&db=m Novel Germline causal interaction,unassigned 4,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805503&form=6&db=m Long non-coding RNA phosphatase and tensin homolog pseudogene 1 suppresses osteosarcoma cell growth via the phosphoinositide 3-kinase/protein kinase B signaling pathway. causal interaction,ongoing research,unassigned 3,1,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30482097&form=6&db=m SLC25A22 Promotes Proliferation and Metastasis of Osteosarcoma Cells via the PTEN Signaling Pathway. causal interaction,unassigned 4,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30523224&form=6&db=m [Effect of Parkinson's disease-relevant protein DJ-1 on cell proliferation, apoptosis, invasion and migration in human osteosarcoma cells]. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31074088&form=6&db=m The CtBP1-p300-FOXO3a transcriptional complex represses the expression of the apoptotic regulators Bax and Bim in human osteosarcoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31270249&form=6&db=m Association between PTEN and clinical-pathological features of osteosarcoma. diagnostic usage,ongoing research,unassigned 4,1,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31598391&form=6&db=m Small molecule TSC01682 inhibits osteosarcoma cell growth by specifically disrupting the CUL4B-DDB1 interaction and decreasing the ubiquitination of CRL4B E3 ligase substrates. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32764941&form=6&db=m Efficient miRNA Inhibitor with GO-PEI Nanosheets for Osteosarcoma Suppression by Targeting PTEN. causal interaction,therapeutic application,unassigned 3,2,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9605750&form=6&db=m Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors. causal interaction,unassigned 4,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9625810&form=6&db=m Mutation analysis of the putative tumor suppressor PTEN/MMAC1 in human ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21297666&form=6&db=m E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via ?-catenin-Egr1-mediated PTEN expression. causal interaction,unassigned 4,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26125866&form=6&db=m Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo. causal interaction,unassigned 1,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26905328&form=6&db=m Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,3 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27481051&form=6&db=m Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer. causal interaction,unassigned 4,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27510094&form=6&db=m MicroRNA-106a regulates phosphatase and tensin homologue expression and promotes the proliferation and invasion of ovarian cancer cells. causal interaction,ongoing research,unassigned 3,3,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28678326&form=6&db=m Expression levels of PTEN, HIF-1?, and VEGF as prognostic factors in ovarian cancer. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29113199&form=6&db=m miR-214 targets the PTEN-mediated PI3K/Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29142608&form=6&db=m Upregulation of microRNA-18b induces phosphatase and tensin homolog to accelerate the migration and invasion abilities of ovarian cancer. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434898&form=6&db=m ABT-737 and pictilisib synergistically enhance pitavastatin-induced apoptosis in ovarian cancer cells. therapeutic application,unassigned 4,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29725462&form=6&db=m miR-205 regulates the proliferation and invasion of ovarian cancer cells via suppressing PTEN/SMAD4 expression. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31206626&form=6&db=m Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32066429&form=6&db=m Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,3,0 3.1.3.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32939058&form=6&db=m METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Pancreatic Intraductal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21945955&form=6&db=m Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458098&form=6&db=m Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.3.67 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17044997&form=6&db=m [Exogenous PTEN enhances apoptosis in pancreas cancer cell line ASPC-1 induced by hypoxia] diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369849&form=6&db=m Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638924&form=6&db=m RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells. causal interaction,unassigned 4,0 3.1.3.67 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20128820&form=6&db=m The role of oxysterol binding protein-related protein 5 in pancreatic cancer. unassigned - 3.1.3.67 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26299428&form=6&db=m Peroxisome proliferator-activated receptor-? inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28442920&form=6&db=m A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 3.1.3.67 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31258546&form=6&db=m miR-486 Promotes Capan-2 Pancreatic Cancer Cell Proliferation by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN). unassigned - 3.1.3.67 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728713&form=6&db=m Overexpression of PTEN/MMAC1 and decreased activation of Akt in human papillomavirus-infected laryngeal papillomas. causal interaction,ongoing research,unassigned 4,2,0 3.1.3.67 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075083&form=6&db=m PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells. causal interaction,unassigned 3,0 3.1.3.67 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30270026&form=6&db=m Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer. ongoing research,unassigned 3,0 3.1.3.67 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31955800&form=6&db=m Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23774695&form=6&db=m Overexpression of phosphatase and tensin homolog improves fitness and decreases Plasmodium falciparum development in Anopheles stephensi. diagnostic usage,unassigned 3,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19358826&form=6&db=m Parkin stabilizes PINK1 through direct interaction. unassigned - 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19847793&form=6&db=m Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect. causal interaction,unassigned 3,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19966284&form=6&db=m PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. causal interaction,unassigned 4,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22238344&form=6&db=m Microtubule Affinity-regulating Kinase 2 (MARK2) Turns on Phosphatase and Tensin Homolog (PTEN)-induced Kinase 1 (PINK1) at Thr-313, a Mutation Site in Parkinson Disease: EFFECTS ON MITOCHONDRIAL TRANSPORT. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22644621&form=6&db=m Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1). causal interaction,unassigned 1,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22645651&form=6&db=m Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. causal interaction,unassigned 3,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27194825&form=6&db=m e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27959386&form=6&db=m PINK1 signaling in mitochondrial homeostasis and in aging (Review). causal interaction,unassigned 4,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29288045&form=6&db=m Elevated nuclear phosphatase and tensin homolog (PTEN) and altered insulin signaling in substantia nigral region of patients with Parkinson's disease. causal interaction,unassigned 4,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29416594&form=6&db=m PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation. unassigned - 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30523224&form=6&db=m [Effect of Parkinson's disease-relevant protein DJ-1 on cell proliferation, apoptosis, invasion and migration in human osteosarcoma cells]. diagnostic usage,ongoing research,unassigned 1,4,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31139191&form=6&db=m Mitochondrial Protein PINK1 Positively Regulates RLR Signaling. causal interaction,unassigned 2,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31336695&form=6&db=m Loss of Non-Apoptotic Role of Caspase-3 in the PINK1 Mouse Model of Parkinson's Disease. ongoing research,unassigned 2,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32150829&form=6&db=m PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER-Mitochondria Contacts in Parkinson's Disease. causal interaction,unassigned 2,0 3.1.3.67 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32713623&form=6&db=m The identified clinical features of Parkinson's disease in homo-, heterozygous and digenic variants of PINK1. ongoing research,unassigned 2,0 3.1.3.67 Peutz-Jeghers Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18672141&form=6&db=m Hamartomatous polyposis syndromes. causal interaction,unassigned 1,0 3.1.3.67 Peutz-Jeghers Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474162&form=6&db=m [Hereditary colorectal cancer : An update on genetics and entities in terms of differential diagnosis]. causal interaction,diagnostic usage,unassigned 2,1,0 3.1.3.67 Peutz-Jeghers Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31107726&form=6&db=m Clinical and Histologic Overlap and Distinction Among Various Hamartomatous Polyposis Syndromes. unassigned - 3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483362&form=6&db=m Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23550155&form=6&db=m c-Myc phosphorylation by PKC? represses prostate tumorigenesis. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23650407&form=6&db=m Phosphatase and tensin homolog deficiency and resistance to trastuzumab and chemotherapy. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24039447&form=6&db=m 3-Phosphoinositide-dependent protein kinase-1 as an emerging target in the management of breast cancer. causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18620995&form=6&db=m Phosphatase and tensin homologue and pituitary tumor-transforming gene in pituitary adenomas. Clinical-pathologic and immunohistochemical analysis. causal interaction,unassigned 4,0 3.1.3.67 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465551&form=6&db=m MicroRNA-106b promotes pituitary tumor cell proliferation and invasion through PI3K/AKT signaling pathway by targeting PTEN. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.1.3.67 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123738&form=6&db=m Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 3.1.3.67 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789441&form=6&db=m Expression and clinical significance of EGR-1 and PTEN in the pituitary tumors of elderly patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 3.1.3.67 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32583210&form=6&db=m Association of genetic variations in phosphatase and tensin homolog (PTEN) gene with polycystic ovary syndrome in South Indian women: a case control study. ongoing research,unassigned 1,0 3.1.3.67 Polyhydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578218&form=6&db=m Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. causal interaction,unassigned 4,0 3.1.3.67 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31896494&form=6&db=m Up-regulation of PTEN via LPS/AP-1/NF-?B pathway inhibits trophoblast invasion contributing to preeclampsia. causal interaction,unassigned 4,0 3.1.3.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22137317&form=6&db=m Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis. causal interaction,unassigned 4,0 3.1.3.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22956625&form=6&db=m Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23788636&form=6&db=m Notch1 receptor regulates AKT protein activation loop (Thr308) dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog (PTEN)-null T-cell acute lymphoblastic leukemia cells. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24552990&form=6&db=m Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24904117&form=6&db=m PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25801032&form=6&db=m FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN-null T-ALL cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1 3.1.3.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27582570&form=6&db=m The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28546582&form=6&db=m Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 3.1.3.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30111390&form=6&db=m [Expression and Significance of PTEN and Survivin in Acute Lymphoblastic Leukemia]. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577685&form=6&db=m Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-cell acute lymphoblastic leukemia. diagnostic usage,ongoing research,unassigned 2,3,0 3.1.3.67 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21212363&form=6&db=m Suppression of leukemia development caused by PTEN loss. ongoing research,unassigned 1,0 3.1.3.67 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32471246&form=6&db=m Clinical-Grade Peptide-Based Inhibition of CK2 Blocks Viability and Proliferation of T-ALL Cells and Counteracts IL-7 Stimulation and Stromal Support. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32479694&form=6&db=m Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3 3.1.3.67 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19449221&form=6&db=m Mutational analysis of the PTEN gene in women with premature ovarian failure. causal interaction,unassigned 3,0 3.1.3.67 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202833&form=6&db=m Intraovarian control of early folliculogenesis. causal interaction,unassigned 1,0 3.1.3.67 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30120633&form=6&db=m Hippo signaling in the ovary and polycystic ovarian syndrome. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26233892&form=6&db=m Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26511486&form=6&db=m Methylseleninic Acid Superactivates p53-Senescence Cancer Progression Barrier in Prostate Lesions of Pten-Knockout Mouse. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.1.3.67 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32162714&form=6&db=m Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer. causal interaction,diagnostic usage,unassigned 1,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9371490&form=6&db=m Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9443392&form=6&db=m Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9560261&form=6&db=m Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9788441&form=6&db=m PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9861013&form=6&db=m The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10360673&form=6&db=m Somatic mutation of PTEN in bladder carcinoma. causal interaction,unassigned 3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10821499&form=6&db=m 10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11234884&form=6&db=m Mutations of PTEN/MMAC1 in primary prostate cancers from Chinese patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309275&form=6&db=m Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414639&form=6&db=m Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12497140&form=6&db=m PTEN/MMAC1 mutations in prostate cancer. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14743465&form=6&db=m Long-term androgen-ablation causes increased resistance to PI3K/Akt pathway inhibition in prostate cancer cells. causal interaction,unassigned 4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984224&form=6&db=m Combination of PTEN gene therapy and radiation inhibits the growth of human prostate cancer xenografts. ongoing research,therapeutic application,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17083125&form=6&db=m Loss of neutral endopeptidase and activation of protein kinase B (Akt) is associated with prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17347137&form=6&db=m The role of PTEN in prostate cancer cell tropism to the bone micro-environment. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17611677&form=6&db=m Uncoupling of the epidermal growth factor receptor from downstream signal transduction molecules guides the acquired resistance to gefitinib in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045951&form=6&db=m Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19052170&form=6&db=m Pharmacological targeting of the integrated protein kinase B, phosphatase and tensin homolog deleted on chromosome 10, and transforming growth factor-beta pathways in prostate cancer. causal interaction,diagnostic usage,unassigned 2,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107233&form=6&db=m Cdc6 and cyclin E2 are PTEN-regulated genes associated with human prostate cancer metastasis. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19683286&form=6&db=m Pathological effects of prostate cancer correlate with neuroendocrine differentiation and PTEN expression after bicalutamide monotherapy. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19787268&form=6&db=m Epigenetic modulation of PTEN expression during antiandrogenic therapies in human prostate cancer. causal interaction,unassigned 2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20197621&form=6&db=m A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. ongoing research,unassigned 2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20515662&form=6&db=m The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21300890&form=6&db=m Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer. therapeutic application,unassigned 1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21627959&form=6&db=m ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22532249&form=6&db=m Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. causal interaction,unassigned 3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22705054&form=6&db=m Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22753496&form=6&db=m JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23018874&form=6&db=m PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade. causal interaction,unassigned 4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23201680&form=6&db=m COUP-TFII inhibits TGF-?-induced growth barrier to promote prostate tumorigenesis. causal interaction,diagnostic usage,unassigned 1,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23258740&form=6&db=m Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23434594&form=6&db=m Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. causal interaction,unassigned 2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23449497&form=6&db=m Predicting high risk disease using serum and DNA biomarkers. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23582881&form=6&db=m Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08). causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23689346&form=6&db=m The influence of growth hormone/insulin-like growth factor deficiency on prostatic dysplasia in pbARR2-Cre, PTEN knockout mice. diagnostic usage,unassigned 4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23695019&form=6&db=m Prognostic value of PTEN loss in men with conservatively managed localised prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,1 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23708662&form=6&db=m Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23830964&form=6&db=m A Phase II Trial of Temsirolimus in Men With Castration-Resistant Metastatic Prostate Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24035134&form=6&db=m Activation of Mammalian Target of Rapamycin Signaling Pathway Markers in Minute Adenocarcinoma of the Prostate. causal interaction,unassigned 1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062990&form=6&db=m Genomic Rearrangements of PTEN in Prostate Cancer. unassigned - 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098737&form=6&db=m Four MicroRNAs Promote Prostate Cell Proliferation with Regulation of PTEN and Its Downstream Signals In Vitro. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24367088&form=6&db=m Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin. ongoing research,unassigned 3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24515272&form=6&db=m Recurrent prostate cancer genomic alterations predict response to brachytherapy treatment. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24525130&form=6&db=m CXCR4 and PTEN are involved in the anti-metastatic regulation of anethole in DU145 prostate cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24700667&form=6&db=m Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling. causal interaction,diagnostic usage,unassigned 3,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24762546&form=6&db=m Heterogeneity and chronology of PTEN deletion and ERG fusion in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25220373&form=6&db=m High Efficacy of Combination Therapy Using PI3K/AKT Inhibitors with Androgen Deprivation in Prostate Cancer Preclinical Models. causal interaction,unassigned 3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25425963&form=6&db=m Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25454616&form=6&db=m PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25773832&form=6&db=m Conditional PTEN-deficient mice as a prostate cancer chemoprevention model. ongoing research,unassigned 4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25939393&form=6&db=m A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26028029&form=6&db=m Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression. causal interaction,unassigned 3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26143945&form=6&db=m AKT and cytosolic phospholipase A2? form a positive loop in prostate cancer cells. causal interaction,unassigned 4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26233892&form=6&db=m Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis. causal interaction,diagnostic usage,unassigned 3,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26260996&form=6&db=m Paucity of PD-L1 expression in prostate cancer: innate and adaptive immune resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26424596&form=6&db=m Frequency of PTEN alterations, TMPRSS2-ERG fusion and their association in prostate cancer. unassigned - 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26504226&form=6&db=m Discovery and functional characterization of a neomorphic PTEN mutation. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26511486&form=6&db=m Methylseleninic Acid Superactivates p53-Senescence Cancer Progression Barrier in Prostate Lesions of Pten-Knockout Mouse. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691865&form=6&db=m IL-6/STAT3/ARF: the guardians of senescence, cancer progression and metastasis in prostate cancer. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26788200&form=6&db=m 2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis. therapeutic application,unassigned 1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26861919&form=6&db=m In prostate cancer needle biopsies, detections of PTEN loss by fluorescence in situ hybridization (FISH) and by immunohistochemistry (IHC) are concordant and show consistent association with upgrading. diagnostic usage,ongoing research,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27284364&form=6&db=m Prognostic value of ERG, PTEN, CRISP3 and SPINK1 in predicting biochemical recurrence in prostate cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27401955&form=6&db=m Is STAT3 and PTEN Expression Altered in Canine Prostate Cancer? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27470558&form=6&db=m The association of Phosphatase and tensin homolog (PTEN) deletion and prostate cancer risk: A meta-analysis. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27721020&form=6&db=m Enhanced growth inhibition of prostate cancer in vitro and in vivo by a recombinant adenovirus-mediated dual-aptamer modified drug delivery system. ongoing research,therapeutic application,unassigned 2,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28282611&form=6&db=m Phase Ib dose-finding study of abiraterone acetate plus buparlisib (BKM120) or dactolisib (BEZ235) in patients with castration-resistant prostate cancer. causal interaction,therapeutic application,unassigned 2,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28319045&form=6&db=m AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,2 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28662290&form=6&db=m Resveratrol and pterostilbene as a microRNA-mediated chemopreventive and therapeutic strategy in prostate cancer. causal interaction,diagnostic usage,unassigned 2,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28875501&form=6&db=m The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression. causal interaction,diagnostic usage,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29163708&form=6&db=m miR-20b promotes cellular proliferation and migration by directly regulating phosphatase and tensin homolog in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29225123&form=6&db=m Clinical Utility and Biologic Implications of Phosphatase and Tensin Homolog (PTEN) and ETS-related Gene (ERG) in Prostate Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29330357&form=6&db=m Knockdown of Phospholipase C? (PLC?) Inhibits Cell Proliferation via Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)/AKT Signaling Pathway in Human Prostate Cancer. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30142405&form=6&db=m The 17-Gene Genomic Prostate Score Assay Predicts Outcome After Radical Prostatectomy Independent of PTEN Status. diagnostic usage,therapeutic application,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30295067&form=6&db=m Effect of Preanalytic Variables on an Automated PTEN Immunohistochemistry Assay for Prostate Cancer. causal interaction,diagnostic usage,unassigned 3,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30496141&form=6&db=m Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. causal interaction,diagnostic usage,unassigned 1,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30614821&form=6&db=m PTEN Loss in a Prostate Cancer Cohort From Jordan. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30888866&form=6&db=m PTEN Expression in Prostate Cancer: Relationship With Clinicopathologic Features and Multiparametric MRI Findings. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015614&form=6&db=m Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31075299&form=6&db=m PTEN and ERG detection in multiparametric magnetic resonance imaging/ultrasound fusion targeted prostate biopsy compared to systematic biopsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186785&form=6&db=m Expression and significance of PTEN and Claudin-3 in prostate cancer. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31212384&form=6&db=m Inflammation-associated pathologies in a case of prostate schistosomiasis: Implications for a causal role in prostate carcinogenesis. diagnostic usage,therapeutic application,unassigned 4,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31452834&form=6&db=m V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31490362&form=6&db=m Increased expression of miR-153 predicts poor prognosis for patients with prostate cancer. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31757845&form=6&db=m Diagnostic value of 68Ga-PSMA PET/CT for detection of PTEN expression in prostate cancer: a pilot study. diagnostic usage,unassigned 4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31914691&form=6&db=m PTEN deletion drives aberrations of DNA methylome and transcriptome in different stages of prostate cancer. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32115152&form=6&db=m Organ-specific regulation of CHD1 by acute PTEN and p53 loss in mice. causal interaction,diagnostic usage,unassigned 2,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32162714&form=6&db=m Proteomic and transcriptomic profiling of Pten gene-knockout mouse model of prostate cancer. causal interaction,diagnostic usage,unassigned 1,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32205016&form=6&db=m A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32355326&form=6&db=m The diverse roles of SPOP in prostate cancer and kidney cancer. causal interaction,therapeutic application,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32884130&form=6&db=m High throughput assessment of biomarkers in tissue microarrays using artificial intelligence: PTEN loss as a proof-of-principle in multi-center prostate cancer cohorts. causal interaction,diagnostic usage,unassigned 4,4,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33034258&form=6&db=m In silico approach of naringin as potent phosphatase and tensin homolog (PTEN) protein agonist against prostate cancer. diagnostic usage,therapeutic application,unassigned 2,2,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33105713&form=6&db=m The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055067&form=6&db=m Silencing miRNA-1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway. unassigned - 3.1.3.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34100390&form=6&db=m Prognostic value of PTEN in de novo diagnosed metastatic prostate cancer. diagnostic usage,ongoing research,unassigned 4,3,0 3.1.3.67 Proteus Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28779187&form=6&db=m Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations. causal interaction,unassigned 3,0 3.1.3.67 Proteus Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30844349&form=6&db=m Congenital Limb Overgrowth Syndromes Associated with Vascular Anomalies. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Proteus Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32689721&form=6&db=m Phosphatase and Tensin Homolog Hamartoma Tumor Syndrome: A Case Report. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26302365&form=6&db=m Nuclear factor-?B pathway activation and phosphatase and tensin homolog downregulation in psoriasis. unassigned - 3.1.3.67 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30483877&form=6&db=m The role of PI3K/AKT/FOXO signaling in psoriasis. causal interaction,ongoing research,unassigned 3,3,0 3.1.3.67 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28855544&form=6&db=m Prostaglandin E1 Attenuates Pulmonary Artery Remodeling by Activating Phosphorylation of CREB and the PTEN Signaling Pathway. unassigned - 3.1.3.67 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28522564&form=6&db=m Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD. causal interaction,ongoing research,unassigned 4,4,0 3.1.3.67 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30290714&form=6&db=m PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577944&form=6&db=m Cigarette smoke extract amplifies NADPH oxidase-dependent ROS production to inactivate PTEN by oxidation in BEAS-2B cells. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21162897&form=6&db=m [Expression of phosphatase and tensin homolog in lower rectal cancer on neoadjuvant chemoradiotherapy]. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22672749&form=6&db=m KRAS Mutation Status and Clinical Outcome of Preoperative Chemoradiation With Cetuximab in Locally Advanced Rectal Cancer: A Pooled Analysis of 2 Phase II Trials. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0 3.1.3.67 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20951693&form=6&db=m PTEN inhibitors cause a negative inotropic and chronotropic effect in mice. unassigned - 3.1.3.67 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25203710&form=6&db=m [Protective role of PTEN inhibition against liver ischemia-reperfusion injury in mice and its underlying mechanisms]. causal interaction,unassigned 2,0 3.1.3.67 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587068&form=6&db=m MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury. causal interaction,unassigned 3,0 3.1.3.67 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34093139&form=6&db=m PTEN Expression Regulates Gap Junction Connectivity in the Retina. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10416987&form=6&db=m Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. causal interaction,unassigned 1,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11407596&form=6&db=m Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas. causal interaction,unassigned 4,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16294307&form=6&db=m Proteome profile changes that are differentially regulated by lipid and protein phosphatase activities of tumor suppressor PTEN in PTEN-expressing U-87 MG human glioblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17699714&form=6&db=m Bevacizumab plus 5-fluorouracil induce growth suppression in the CWR-22 and CWR-22R prostate cancer xenografts. causal interaction,unassigned 3,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18060101&form=6&db=m Arterialization of a vein graft promotes cell cycle progression through Akt and p38 mitogen-activated protein kinase pathways: impact of the preparation procedure. causal interaction,unassigned 2,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20019182&form=6&db=m Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. causal interaction,unassigned 4,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22981675&form=6&db=m Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity. causal interaction,unassigned 3,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24862260&form=6&db=m Regulation of cancer metabolism by oncogenes and tumor suppressors. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25749195&form=6&db=m Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. unassigned - 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28951314&form=6&db=m Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. ongoing research,unassigned 2,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31024258&form=6&db=m Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32240666&form=6&db=m MED12 exon 2 mutation is uncommon in intravenous leiomyomatosis: clinicopathologic features and molecular study. diagnostic usage,unassigned 3,0 3.1.3.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32532965&form=6&db=m Regulating tumor suppressor genes: post-translational modifications. causal interaction,unassigned 2,0 3.1.3.67 Rett Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468183&form=6&db=m Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism. causal interaction,unassigned 3,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12569572&form=6&db=m PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20564403&form=6&db=m Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21240992&form=6&db=m Prevalence and prognostic influence of genomic changes of EGFR pathway markers in synovial sarcoma. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285871&form=6&db=m Utilization of Unlabeled Probes for the Detection of Fibroblast Growth Factor Receptor 2 Exons 7 and 12 Mutations in Endometrial Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21742964&form=6&db=m Concordance of Predictive Markers for EGFR Inhibitors in Primary Tumors and Metastases in Colorectal Cancer: A Review. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,4,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24114272&form=6&db=m Evolutionary etiology of high-grade astrocytomas. unassigned - 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24823994&form=6&db=m Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay. causal interaction,diagnostic usage,unassigned 1,1,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25751063&form=6&db=m A versatile modular vector system for rapid combinatorial mammalian genetics. therapeutic application,unassigned 2,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27919956&form=6&db=m Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599463&form=6&db=m Cancer gene panel analysis of cultured circulating tumor cells and primary tumor tissue from patients with breast cancer. causal interaction,unassigned 3,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29410288&form=6&db=m Identification of key microRNAs, transcription factors and genes associated with congenital obstructive nephropathy in a mouse model of megabladder. causal interaction,unassigned 1,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29720878&form=6&db=m EGFR, KRAS, BRAF, PTEN, and PIK3CA mutation in plasma of small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30275180&form=6&db=m Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30867798&form=6&db=m Molecular association of functioning stroma with carcinoma cells in the ovary: A preliminary study. diagnostic usage,ongoing research,unassigned 1,2,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31416195&form=6&db=m The PTEN Tumor Suppressor Gene in Soft Tissue Sarcoma. unassigned - 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31683701&form=6&db=m Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma. causal interaction,unassigned 3,0 3.1.3.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149905&form=6&db=m Next-generation sequencing-based identification of EGFR and NOTCH2 complementary mutations in non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 4,2,0 3.1.3.67 Scleroderma, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23983074&form=6&db=m Fibrosis caused by loss of PTEN expression by fibroblasts is crucially dependent on CCN2. causal interaction,unassigned 3,0 3.1.3.67 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23983074&form=6&db=m Fibrosis caused by loss of PTEN expression by fibroblasts is crucially dependent on CCN2. causal interaction,unassigned 3,0 3.1.3.67 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30075746&form=6&db=m Role of the mTOR pathway in minor salivary gland changes in Sjogren's syndrome and systemic sclerosis. diagnostic usage,unassigned 1,0 3.1.3.67 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31636454&form=6&db=m Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. unassigned - 3.1.3.67 Seminoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22810004&form=6&db=m Estrogen receptor beta (ER?) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. ongoing research,unassigned 4,0 3.1.3.67 Seminoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30266250&form=6&db=m Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma. diagnostic usage,ongoing research,unassigned 2,1,0 3.1.3.67 Sjogren's Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30075746&form=6&db=m Role of the mTOR pathway in minor salivary gland changes in Sjogren's syndrome and systemic sclerosis. diagnostic usage,unassigned 1,0 3.1.3.67 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25191969&form=6&db=m Role of vitamin D3 in modulation of ?Np63? expression during UVB induced tumor formation in SKH-1 mice. causal interaction,unassigned 1,0 3.1.3.67 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9467947&form=6&db=m Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines. ongoing research,unassigned 3,0 3.1.3.67 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696041&form=6&db=m PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 3.1.3.67 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28786540&form=6&db=m Concurrent epidermal growth factor receptor T790M secondary mutation and epithelial-mesenchymal transition in a lung adenocarcinoma patient with EGFR-TKI drug resistance. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22253859&form=6&db=m Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25057197&form=6&db=m AAVshRNA-mediated suppression of PTEN in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury. unassigned - 3.1.3.67 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25704959&form=6&db=m Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice. unassigned - 3.1.3.67 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26896833&form=6&db=m Long-term consequences of conditional genetic deletion of PTEN in the sensorimotor cortex of neonatal mice. ongoing research,unassigned 1,0 3.1.3.67 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29454667&form=6&db=m PTEN expression in astrocytic processes after spinal cord injury. unassigned - 3.1.3.67 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31454225&form=6&db=m Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury. unassigned - 3.1.3.67 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32297644&form=6&db=m MicroRNA-92a-3p enhances functional recovery and suppresses apoptosis after spinal cord injury via targeting phosphatase and tensin homolog. therapeutic application,unassigned 2,0 3.1.3.67 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33433490&form=6&db=m ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury. causal interaction,unassigned 4,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458098&form=6&db=m Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9778300&form=6&db=m Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10404099&form=6&db=m Loss of heterozygosity at 10q in tumors of the upper respiratory tract is associated with poor prognosis. causal interaction,unassigned 4,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11801303&form=6&db=m Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332346&form=6&db=m Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer. unassigned - 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20079266&form=6&db=m [Mutation and expression of tumor suppressor gene phosphatase and tensin homolog deleted in chromosome 10 in oral squamous cell carcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20546613&form=6&db=m Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23601218&form=6&db=m Phosphorylated mammalian target of rapamycin is associated with an adverse outcome in oral squamous cell carcinoma. ongoing research,unassigned 3,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120657&form=6&db=m Phosphatase and tensin homolog overexpression decreases proliferation and invasion and increases apoptosis in oral squamous cell carcinoma cells. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25174622&form=6&db=m Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,3,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994422&form=6&db=m Immunohistochemical expression of phosphatase and tensin homolog in histologic gradings of oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423242&form=6&db=m Correlation between PTEN gene polymorphism and oral squamous cell carcinoma. ongoing research,unassigned 4,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31453348&form=6&db=m PTEN Is Associated With Worse Local Control in Early Stage Supraglottic Laryngeal Cancer Treated With Radiotherapy. diagnostic usage,ongoing research,unassigned 4,4,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31560860&form=6&db=m Hypoxic niches are endowed with a protumorigenic mechanism that supersedes the protective function of PTEN. causal interaction,ongoing research,unassigned 3,2,0 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31785230&form=6&db=m PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3 3.1.3.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33959238&form=6&db=m PTEN and ?-SMA Expression and Diagnostic Role in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma with Concomitant Oral Submucous Fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1 3.1.3.67 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051596&form=6&db=m Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas. causal interaction,unassigned 4,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458098&form=6&db=m Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15818730&form=6&db=m Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene. ongoing research,therapeutic application,unassigned 4,2,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16264263&form=6&db=m PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells. causal interaction,ongoing research,unassigned 4,3,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20089040&form=6&db=m Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation. therapeutic application,unassigned 1,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23402578&form=6&db=m Increased Gastric Cancer Risk with PTEN IVS4 Polymorphism in a Turkish Population. diagnostic usage,ongoing research,unassigned 1,3,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24571667&form=6&db=m NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1? induction. ongoing research,unassigned 3,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24659669&form=6&db=m MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881601&form=6&db=m CDX2 inhibits invasion and migration of gastric cancer cells by phosphatase and tensin homologue deleted from chromosome 10/Akt signaling pathway. causal interaction,unassigned 4,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26753960&form=6&db=m Downregulation of microRNA-193-3p inhibits tumor proliferation migration and chemoresistance in human gastric cancer by regulating PTEN gene. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26934444&form=6&db=m An increase in galectin-3 causes cellular unresponsiveness to IFN-?-induced signal transduction and growth inhibition in gastric cancer cells. ongoing research,unassigned 2,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28412247&form=6&db=m Activation of phospholipase C-?1 and translocation of phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase contribute to GL-V9-induced apoptosis in human gastric cancer cells. ongoing research,unassigned 2,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28931965&form=6&db=m Polymorphisms in lncRNA PTENP1 and the Risk of Gastric Cancer in a Chinese Population. causal interaction,unassigned 3,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28950928&form=6&db=m Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly Targeting PTEN. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28978026&form=6&db=m Enhanced antiproliferative activity of antibody-functionalized polymeric nanoparticles for targeted delivery of anti-miR-21 to HER2 positive gastric cancer. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29115517&form=6&db=m MicroRNA-197 inhibits gastric cancer progression by directly targeting metadherin. diagnostic usage,ongoing research,unassigned 3,1,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29436592&form=6&db=m Concomitant modulation of PTEN and Livin in gastric cancer treatment. causal interaction,unassigned 1,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512701&form=6&db=m Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p?AURKA mediated by activation of AURKA. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29541241&form=6&db=m Microrna-136 promotes proliferation and invasion ingastric cancer cells through Pten/Akt/P-Akt signaling pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30131483&form=6&db=m High miR-718 Suppresses Phosphatase and Tensin Homolog (PTEN) Expression and Correlates to Unfavorable Prognosis in Gastric Cancer. causal interaction,diagnostic usage,unassigned 3,3,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30777076&form=6&db=m CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31318186&form=6&db=m Prognostic importance of PTEN, EGFR, HER-2, and IGF-1R in gastric cancer patients treated with postoperative chemoradiation diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31444971&form=6&db=m Micro-RNA 205-5p is Involved in the Progression of Gastric Cancer and Targets Phosphatase and Tensin Homolog (PTEN) in SGC-7901 Human Gastric Cancer Cells. ongoing research,unassigned 2,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32756305&form=6&db=m PTEN, a Barrier for Proliferation and Metastasis of Gastric Cancer Cells: From Molecular Pathways to Targeting and Regulation. ongoing research,therapeutic application,unassigned 3,1,0 3.1.3.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33132637&form=6&db=m Acetyl-11-keto-?-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735908&form=6&db=m Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion and restraint stress-induced gastric ulcers in rats. diagnostic usage,ongoing research,unassigned 3,3,0 3.1.3.67 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102920&form=6&db=m Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. causal interaction,therapeutic application,unassigned 1,4,0 3.1.3.67 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23219909&form=6&db=m Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke. therapeutic application,unassigned 4,0 3.1.3.67 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28232590&form=6&db=m MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats. causal interaction,therapeutic application,unassigned 1,3,0 3.1.3.67 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30672370&form=6&db=m Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3K/AKT-mTOR signaling following traumatic spinal injuries. causal interaction,therapeutic application,unassigned 3,4,0 3.1.3.67 Sturge-Weber Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28779187&form=6&db=m Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations. causal interaction,unassigned 3,0 3.1.3.67 Sturge-Weber Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30844349&form=6&db=m Congenital Limb Overgrowth Syndromes Associated with Vascular Anomalies. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22183833&form=6&db=m Treatment with sodium orthovanadate reduces blood-brain barrier disruption via phosphatase and tensin homolog deleted on chromosome 10 (PTEN) phosphorylation in experimental subarachnoid hemorrhage. therapeutic application,unassigned 4,0 3.1.3.67 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25575796&form=6&db=m Administration of a PTEN inhibitor BPV(pic) attenuates early brain injury via modulating AMPA receptor subunits after subarachnoid hemorrhage in rats. ongoing research,unassigned 2,0 3.1.3.67 Telangiectasia, Hereditary Hemorrhagic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446851&form=6&db=m Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. unassigned - 3.1.3.67 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446851&form=6&db=m Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. unassigned - 3.1.3.67 Telangiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31206626&form=6&db=m Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Testicular Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19237610&form=6&db=m Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19164214&form=6&db=m Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. causal interaction,therapeutic application,unassigned 4,2,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20112301&form=6&db=m Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats. ongoing research,unassigned 1,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21243487&form=6&db=m Cardioprotective MicroRNAs. causal interaction,unassigned 4,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24632578&form=6&db=m Combined Effects of Genetic Variants of the PTEN, AKT1, MDM2 and p53 Genes on the Risk of Nasopharyngeal Carcinoma. causal interaction,unassigned 2,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25919186&form=6&db=m miR-144/451 Promote Cell Proliferation via Targeting PTEN/AKT Pathway in Insulinomas. causal interaction,unassigned 2,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27068875&form=6&db=m A common variation of the PTEN gene is associated with peripheral insulin resistance. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27186313&form=6&db=m microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. causal interaction,unassigned 2,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27919956&form=6&db=m Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30246429&form=6&db=m Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling. unassigned - 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33535663&form=6&db=m An Immunohistochemical Study of the PTEN/AKT Pathway Involvement in Canine and Feline Mammary Tumors. ongoing research,unassigned 2,0 3.1.3.67 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33749526&form=6&db=m PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. therapeutic application,unassigned 1,0 3.1.3.67 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10741010&form=6&db=m Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.1.3.67 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10741010&form=6&db=m Mutation analysis of PTEN/MMAC 1 in sporadic thyroid tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 3.1.3.67 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16487009&form=6&db=m PTEN Promoter Methylation in Sporadic Thyroid Carcinomas. causal interaction,therapeutic application,unassigned 3,1,0 3.1.3.67 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20600018&form=6&db=m Frequent Gastrointestinal Polyps and Colorectal Adenocarcinomas in a Prospective Series of PTEN Mutation Carriers. causal interaction,unassigned 3,0 3.1.3.67 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22962422&form=6&db=m PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1 3.1.3.67 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379037&form=6&db=m Thyroid involvement in two patients with Bannayan-Riley-Ruvalcaba syndrome. causal interaction,unassigned 3,0 3.1.3.67 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916396&form=6&db=m Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder. causal interaction,diagnostic usage,unassigned 4,2,0 3.1.3.67 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31973533&form=6&db=m miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN. diagnostic usage,ongoing research,unassigned 4,2,0 3.1.3.67 Thyroid Nodule http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32286703&form=6&db=m Diagnostic significance of DNA methylation of PTEN and DAPK in thyroid tumors. diagnostic usage,unassigned 4,0 3.1.3.67 Thyroiditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379037&form=6&db=m Thyroid involvement in two patients with Bannayan-Riley-Ruvalcaba syndrome. causal interaction,unassigned 3,0 3.1.3.67 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147502&form=6&db=m Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0 3.1.3.67 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133717&form=6&db=m Selective targeting of radiation-resistant tumor-initiating cells. diagnostic usage,ongoing research,unassigned 3,2,0 3.1.3.67 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28671671&form=6&db=m Wnt/?-catenin activation and macrophage induction during liver cancer development following steatosis. therapeutic application,unassigned 2,0 3.1.3.67 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30861992&form=6&db=m Preventive Effect of Lactobacillus fermentum CQPC08 on 4-Nitroquineline-1-Oxide Induced Tongue Cancer in C57BL/6 Mice. causal interaction,unassigned 3,0 3.1.3.67 transaldolase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32506314&form=6&db=m Systemic lupus erythematosus in a girl with PTEN variant and transaldolase deficiency: a novel phenotype. causal interaction,unassigned 4,0 3.1.3.67 Tremor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29720545&form=6&db=m Multifocal demyelinating motor neuropathy and hamartoma syndrome associated with a de novo PTEN mutation. causal interaction,unassigned 4,0 3.1.3.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20943632&form=6&db=m Treatment of triple-negative metastatic breast cancer: toward individualized targeted treatments or chemosensitization? causal interaction,therapeutic application,unassigned 4,1,0 3.1.3.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629823&form=6&db=m Non-Specific Blocking of miR-17-5p Guide Strand in Triple Negative Breast Cancer Cells by Amplifying Passenger Strand Activity. unassigned - 3.1.3.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217901&form=6&db=m PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33003585&form=6&db=m Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner. causal interaction,therapeutic application,unassigned 3,3,0 3.1.3.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300431&form=6&db=m DCAF13 promotes triple-negative breast cancer metastasis by mediating DTX3 mRNA degradation. ongoing research,unassigned 1,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16757550&form=6&db=m Developmental regulation of the activation of signaling components leading to translation initiation in skeletal muscle of neonatal pigs. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785597&form=6&db=m Postnatal ontogeny of skeletal muscle protein synthesis in pigs. unassigned - 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17997386&form=6&db=m Targeting phosphoinositide 3-kinase: moving towards therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917848&form=6&db=m Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. causal interaction,diagnostic usage,unassigned 4,3,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21547565&form=6&db=m Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22184110&form=6&db=m Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. ongoing research,unassigned 3,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22578218&form=6&db=m Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. causal interaction,unassigned 4,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22619737&form=6&db=m Plasticity and mTOR: towards restoration of impaired synaptic plasticity in mTOR-related neurogenetic disorders. causal interaction,unassigned 4,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376645&form=6&db=m Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24515103&form=6&db=m Transforming Growth Factor-? Signaling Participates in the Maintenance of the Primordial Follicle Pool in the Mouse Ovary. causal interaction,ongoing research,unassigned 1,2,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24677093&form=6&db=m Role of AMP-Activated Protein Kinase in Cancer Therapy. causal interaction,therapeutic application,unassigned 4,4,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25382660&form=6&db=m The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration. unassigned - 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468183&form=6&db=m Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism. causal interaction,unassigned 3,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27071790&form=6&db=m mTOR, a Potential Target to Treat Autism Spectrum Disorder. causal interaction,unassigned 2,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29672222&form=6&db=m Macrophage-derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse. causal interaction,unassigned 3,0 3.1.3.67 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31896113&form=6&db=m Immunohistochemical Analysis of mTOR Pathway-Related Proteins in Kaposiform Hemangioendothelioma. ongoing research,unassigned 1,0 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9671402&form=6&db=m Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10360673&form=6&db=m Somatic mutation of PTEN in bladder carcinoma. causal interaction,unassigned 3,0 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26853465&form=6&db=m Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. unassigned - 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28042869&form=6&db=m Genome-Wide Screen of miRNAs and Targeting mRNAs Reveals the Negatively Regulatory Effect of miR-130b-3p on PTEN by PI3K and Integrin ?1 Signaling Pathways in Bladder Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28069380&form=6&db=m microRNA-495 promotes bladder cancer cell growth and invasion by targeting phosphatase and tensin homolog. unassigned - 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29021651&form=6&db=m MicroRNA-21 could be a molecular marker to predict the recurrence of nonmuscle invasive bladder cancer. causal interaction,ongoing research,unassigned 2,2,0 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333873&form=6&db=m ?-elemene induced anticancer effect in bladder cancer through upregulation of PTEN and suppression of AKT phosphorylation. diagnostic usage,ongoing research,unassigned 3,4,0 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31555390&form=6&db=m Heterogeneity of PTEN and PPAR-? in cancer and their prognostic application to bladder cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31612063&form=6&db=m MicroRNA-34a inhibits bladder cancer cell migration and invasion, and upregulates PTEN expression. unassigned - 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31814034&form=6&db=m Bladder cancer cell?secreted exosomal miR?21 activates the PI3K/AKT pathway in macrophages to promote cancer progression. causal interaction,ongoing research,unassigned 1,1,0 3.1.3.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33104021&form=6&db=m Long noncoding RNA MAGI2-AS3 inhibits bladder cancer progression through MAGI2/PTEN/epithelial-mesenchymal transition (EMT) axis. ongoing research,therapeutic application,unassigned 2,1,0 3.1.3.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10637069&form=6&db=m Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 3.1.3.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22016029&form=6&db=m Silymarin Inhibits Cervical Cancer Cell Through an Increase of Phosphatase and Tensin Homolog. therapeutic application,unassigned 2,0 3.1.3.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25018014&form=6&db=m MicroRNA?10a enhances the metastatic potential of cervical cancer cells by targeting phosphatase and tensin homologue. causal interaction,therapeutic application,unassigned 1,2,0 3.1.3.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738254&form=6&db=m MicroRNA?494 promotes cervical cancer proliferation through the regulation of PTEN. causal interaction,unassigned 3,0 3.1.3.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27040383&form=6&db=m Nuclear factor-?B-dependent microRNA-130a upregulation promotes cervical cancer cell growth by targeting phosphatase and tensin homolog. unassigned - 3.1.3.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28658642&form=6&db=m Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers. causal interaction,unassigned 4,0 3.1.3.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29316891&form=6&db=m Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms. causal interaction,unassigned 3,0 3.1.3.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32552146&form=6&db=m Correlation Between Single Nucleotide Polymorphisms of an miRNA Binding Site in the 3'UTR of PTEN and Risk of Cervical Cancer Among the Han Chinese. diagnostic usage,ongoing research,unassigned 1,1,0 3.1.3.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34407056&form=6&db=m Long noncoding RNA ALOX12-AS1 inhibits cervical cancer cells proliferation via targeting miR-3171. ongoing research,unassigned 4,0 3.1.3.67 Uterine Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657903&form=6&db=m Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 3.1.3.67 Uveitis, Intermediate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31603075&form=6&db=m Intermediate uveitis in a child with phosphatase and tensin homolog gene mutation and Bannayan-Riley-Ruvalcaba syndrome. causal interaction,unassigned 3,0 3.1.3.67 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21730175&form=6&db=m Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. therapeutic application,unassigned 1,0 3.1.3.67 Vascular Malformations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28779187&form=6&db=m Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 2: vascular malformations. causal interaction,unassigned 3,0 3.1.3.67 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31941556&form=6&db=m Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 3.1.3.67 von Hippel-Lindau Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0 3.1.3.67 Werner Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31452757&form=6&db=m Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer. causal interaction,unassigned 3,0 3.1.3.67 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20381115&form=6&db=m Loss of PTEN/MMAC1 activity is a rare and late event in the pathogenesis of nephroblastomas. causal interaction,unassigned 3,0 3.1.3.67 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31316599&form=6&db=m Aberrant expression and mechanism of miR-130b-3p/phosphatase and tensin homolog in nephroblastoma in children. unassigned -