2.7.1.20 5'-nucleotidase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24972650&form=6&db=m Inborn errors of purine metabolism: clinical update and therapies. causal interaction,therapeutic application,unassigned 3,1,0 2.7.1.20 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740614&form=6&db=m Involvement of adenosine in depression of synaptic transmission during hypercapnia in isolated spinal cord of neonatal rats. therapeutic application,unassigned 2,0 2.7.1.20 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30995110&form=6&db=m Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.7.1.20 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32544464&form=6&db=m Adenosine kinase inhibition attenuates ischemia reperfusion-induced acute kidney injury. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26491864&form=6&db=m Inhibition of Adenosine Kinase Attenuates Acute Lung Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.1.20 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493963&form=6&db=m Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity. unassigned - 2.7.1.20 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14755964&form=6&db=m Microscopic morphometry--a modern approach. unassigned - 2.7.1.20 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32762399&form=6&db=m A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. causal interaction,unassigned 1,0 2.7.1.20 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1917150&form=6&db=m Univariate and multivariate analyses of the relationship between adenocarcinoma and solitary and multiple adenomas in colorectal adenoma patients. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835956&form=6&db=m Adenosine kinase deficiency in tritiated deoxyadenosine-resistant mouse S49 lymphoma cell lines. causal interaction,unassigned 2,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6330251&form=6&db=m S-adenosylhomocysteine hydrolase inactivation and purine toxicity in cultured human T- and B-lymphoblasts. therapeutic application,unassigned 1,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6683274&form=6&db=m Increased expression of one of two adenosine deaminase alleles in a human choriocarcinoma cell line following selection with adenine nucleosides. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6863404&form=6&db=m Adenosine and tubercidin binding and transport in Chinese hamster ovary and Novikoff rat hepatoma cells. unassigned - 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891238&form=6&db=m Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation. causal interaction,unassigned 4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21963049&form=6&db=m Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. causal interaction,unassigned 4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25762406&form=6&db=m Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26642971&form=6&db=m Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26993811&form=6&db=m MRI and (1)H-MRS in adenosine kinase deficiency. causal interaction,unassigned 4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27500280&form=6&db=m Adenosine kinase deficiency with neurodevelopemental delay and recurrent hepatic dysfunction: A case report. causal interaction,unassigned 4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27671891&form=6&db=m Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27903722&form=6&db=m Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29126171&form=6&db=m Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility. causal interaction,unassigned 4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29344645&form=6&db=m Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30477030&form=6&db=m Adenosine Kinase Deficiency: Report and Review. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30771478&form=6&db=m Whole exome sequencing revealed mutations in FBXL4, UNC80, and ADK in Thai patients with severe intellectual disabilities. causal interaction,unassigned 4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30944910&form=6&db=m Adenosine Kinase Deficiency Increases Susceptibility to a Carcinogen. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31044530&form=6&db=m Deletion of pancreatic ?-cell adenosine kinase improves glucose homeostasis in young mice and ameliorates streptozotocin-induced hyperglycaemia. ongoing research,unassigned 4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31189131&form=6&db=m Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309011&form=6&db=m Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34347214&form=6&db=m S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver. causal interaction,therapeutic application,unassigned 3,1,0 2.7.1.20 adenosine kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34485018&form=6&db=m Clinical utility of methionine restriction in adenosine kinase deficiency. causal interaction,unassigned 4,0 2.7.1.20 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34054547&form=6&db=m Metabolic Aspects of Adenosine Functions in the Brain. ongoing research,unassigned 2,0 2.7.1.20 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29791204&form=6&db=m Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia. causal interaction,diagnostic usage,unassigned 3,1,0 2.7.1.20 Aniridia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7668281&form=6&db=m Mutation of the PAX6 gene in patients with autosomal dominant keratitis. causal interaction,unassigned 4,0 2.7.1.20 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160636&form=6&db=m Anti-inflammatory effects of ABT-702, a novel non-nucleoside adenosine kinase inhibitor, in rat adjuvant arthritis. ongoing research,therapeutic application,unassigned 2,4,0 2.7.1.20 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29308612&form=6&db=m Stable Knockdown of Adenosine Kinase by Lentiviral Anti-ADK miR-shRNAs in Wharton's Jelly Stem Cells. ongoing research,unassigned 4,0 2.7.1.20 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29038540&form=6&db=m Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation. causal interaction,ongoing research,unassigned 4,2,0 2.7.1.20 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30571174&form=6&db=m Ablation of Myeloid ADK (Adenosine Kinase) Epigenetically Suppresses Atherosclerosis in ApoE-/- (Apolipoprotein E Deficient) Mice. ongoing research,therapeutic application,unassigned 3,2,0 2.7.1.20 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29344645&form=6&db=m Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2 2.7.1.20 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12046508&form=6&db=m [Neuroprotective mechanisms of adenosine action on CNS neurons] causal interaction,therapeutic application,unassigned 1,4,0 2.7.1.20 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21963049&form=6&db=m Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. causal interaction,unassigned 4,0 2.7.1.20 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8981476&form=6&db=m Pre- and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats. ongoing research,therapeutic application,unassigned 1,4,0 2.7.1.20 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056128&form=6&db=m Adenosine kinase, epilepsy and stroke: mechanisms and therapies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.7.1.20 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18172552&form=6&db=m Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.1.20 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18249058&form=6&db=m The adenosine kinase hypothesis of epileptogenesis. unassigned - 2.7.1.20 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21427729&form=6&db=m Adenosine kinase determines the degree of brain injury after ischemic stroke in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4 2.7.1.20 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21635241&form=6&db=m Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.1.20 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27812320&form=6&db=m Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.1.20 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31633474&form=6&db=m Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.1.20 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040919&form=6&db=m Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.7.1.20 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26983602&form=6&db=m Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury. therapeutic application,unassigned 1,0 2.7.1.20 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322821&form=6&db=m Adenosine kinase inhibition promotes proliferation of neural stem cells after traumatic brain injury. causal interaction,therapeutic application,unassigned 2,1,0 2.7.1.20 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9059845&form=6&db=m Adenosine kinase inhibition protects brain against transient focal ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.1.20 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21427729&form=6&db=m Adenosine kinase determines the degree of brain injury after ischemic stroke in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4 2.7.1.20 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26983602&form=6&db=m Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury. therapeutic application,unassigned 1,0 2.7.1.20 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987452&form=6&db=m Preventive and curative effect of melatonin on mammary carcinogenesis induced by dimethylbenz[a]anthracene in the female Sprague-Dawley rat. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22388174&form=6&db=m Intracellularly transported adenosine induces MCF-7 human breast cancer cells by accumulating AMID in the nucleus. therapeutic application,unassigned 4,0 2.7.1.20 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921385&form=6&db=m Dysregulation of adenosine kinase isoforms in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.1.20 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921385&form=6&db=m Dysregulation of adenosine kinase isoforms in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.1.20 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2092181&form=6&db=m [Kinetics of degradation and resynthesis of the adenine-nucleotide pool in tumor cells] unassigned - 2.7.1.20 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493963&form=6&db=m Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity. unassigned - 2.7.1.20 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30642539&form=6&db=m Outcome of EGFR-mutated adenocarcinoma NSCLC patients with changed phenotype to squamous cell carcinoma after tyrosine kinase inhibitors: A pooled analysis with an additional case. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=174138&form=6&db=m Feedback inhibition by 6-methylthioinosine 3',5'-cyclic monophosphate in tumor cells resistant to the nucleoside. unassigned - 2.7.1.20 Carcinoma, Ehrlich Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5062817&form=6&db=m Kinetic studies of adenosine kinase from Ehrlich ascites tumor cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.1.20 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=207296&form=6&db=m Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,2 2.7.1.20 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2092181&form=6&db=m [Kinetics of degradation and resynthesis of the adenine-nucleotide pool in tumor cells] unassigned - 2.7.1.20 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6162556&form=6&db=m Biochemical approaches to enhancement of antitumor drug selectivity: selective protection of cells from 6-thioguanine and 6-mercaptopurine by adenosine. diagnostic usage,unassigned 3,0 2.7.1.20 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6167445&form=6&db=m Pyrazofurin-resistant hepatoma cells deficient in adenosine kinase. causal interaction,ongoing research,unassigned 2,2,0 2.7.1.20 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6951080&form=6&db=m Rat hepatomas: chemotherapy with lycurim and pyrazofurin. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.1.20 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6981855&form=6&db=m Isolation of deoxycoformycin-resistant cells with increased levels of adenosine deaminase. ongoing research,unassigned 1,0 2.7.1.20 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493963&form=6&db=m Pre-clinical evaluation of new antineoplastic agents in NSCLC cell lines: evidence of histological subtype-dependent cytotoxicity. unassigned - 2.7.1.20 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30642539&form=6&db=m Outcome of EGFR-mutated adenocarcinoma NSCLC patients with changed phenotype to squamous cell carcinoma after tyrosine kinase inhibitors: A pooled analysis with an additional case. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24841126&form=6&db=m Adenosine kinase inhibition protects the kidney against streptozotocin-induced diabetes through anti-inflammatory and anti-oxidant mechanisms. unassigned - 2.7.1.20 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309011&form=6&db=m Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.1.20 Cholesteatoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15370560&form=6&db=m Proteomic analysis of cholesteatoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.7.1.20 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11123368&form=6&db=m Adenosine kinase inhibitor GP515 improves experimental colitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.1.20 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18600536&form=6&db=m Adenosine kinase gene expression in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.1.20 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20331978&form=6&db=m Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state. therapeutic application,unassigned 1,0 2.7.1.20 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324223&form=6&db=m Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities. therapeutic application,unassigned 2,0 2.7.1.20 Cystadenocarcinoma, Serous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32239119&form=6&db=m A rare case of synchronous ovarian tumors: clinical case report and literature review. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.1.20 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683243&form=6&db=m Decreased expression of adenosine kinase in streptozotocin-induced diabetes mellitus rats. diagnostic usage,unassigned 3,0 2.7.1.20 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12190116&form=6&db=m Insulin restores expression of adenosine kinase in streptozotocin-induced diabetes mellitus rats. diagnostic usage,ongoing research,unassigned 3,2,0 2.7.1.20 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23840723&form=6&db=m Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.1.20 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30699363&form=6&db=m Adenosine kinase and cardiovascular fetal programming in gestational diabetes mellitus. unassigned - 2.7.1.20 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23770229&form=6&db=m ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0 2.7.1.20 Drug Resistant Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21275977&form=6&db=m Adenosine kinase as a target for therapeutic antisense strategies in epilepsy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Drug Resistant Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21701065&form=6&db=m A ketogenic diet suppresses seizures in mice through adenosine A? receptors. unassigned - 2.7.1.20 Drug Resistant Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31633474&form=6&db=m Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.1.20 Drug Resistant Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34479194&form=6&db=m Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.1.20 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24128682&form=6&db=m Upregulation of adenosine kinase in Rasmussen encephalitis. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14736855&form=6&db=m Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930047&form=6&db=m Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16059492&form=6&db=m Adenosine kinase elevation increases activity in the kainic acid model of epilepsy. causal interaction,ongoing research,unassigned 1,1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685255&form=6&db=m Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. causal interaction,ongoing research,unassigned 4,3,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056128&form=6&db=m Adenosine kinase, epilepsy and stroke: mechanisms and therapies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18172552&form=6&db=m Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18634566&form=6&db=m Adenosine dysfunction in astrogliosis: cause for seizure generation? causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19682439&form=6&db=m Therapeutic epilepsy research: From pharmacological rationale to focal adenosine augmentation. causal interaction,unassigned 3,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20633035&form=6&db=m Inhibitory RNA in epilepsy: research tools and therapeutic perspectives. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20730044&form=6&db=m Adenosine dysfunction and adenosine kinase in epileptogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21275977&form=6&db=m Adenosine kinase as a target for therapeutic antisense strategies in epilepsy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21635241&form=6&db=m Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21919845&form=6&db=m Adenosine A(1) Receptors in the Central Nervous System: Their Functions in Health and Disease, and Possible Elucidation by PET Imaging. causal interaction,therapeutic application,unassigned 1,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22092111&form=6&db=m Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy. causal interaction,unassigned 4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22700220&form=6&db=m Adenosine dysfunction in epilepsy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23592612&form=6&db=m Adenosine kinase: exploitation for therapeutic gain. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24128682&form=6&db=m Upregulation of adenosine kinase in Rasmussen encephalitis. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24266544&form=6&db=m Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice. ongoing research,therapeutic application,unassigned 2,1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25231174&form=6&db=m Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25575137&form=6&db=m Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25979489&form=6&db=m Comorbidities in Neurology: Is adenosine the common link? ongoing research,unassigned 1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040919&form=6&db=m Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26329539&form=6&db=m Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26983602&form=6&db=m Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury. therapeutic application,unassigned 1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26993811&form=6&db=m MRI and (1)H-MRS in adenosine kinase deficiency. causal interaction,unassigned 4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27410258&form=6&db=m South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase. causal interaction,therapeutic application,unassigned 2,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27812320&form=6&db=m Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27915186&form=6&db=m Role of the purinergic signaling in epilepsy. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29126171&form=6&db=m Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility. causal interaction,unassigned 4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30815855&form=6&db=m Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31633474&form=6&db=m Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32243580&form=6&db=m Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33161022&form=6&db=m Adenosine kinase: A key regulator of purinergic physiology. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309011&form=6&db=m Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33496919&form=6&db=m Computational exploration of vicine - an alkaloid glycoside mediated pathological hallmark of adenosine kinase to promote neurological disorder. ongoing research,therapeutic application,unassigned 2,2,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34054547&form=6&db=m Metabolic Aspects of Adenosine Functions in the Brain. ongoing research,unassigned 2,0 2.7.1.20 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34479194&form=6&db=m Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.1.20 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14736855&form=6&db=m Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.1.20 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930047&form=6&db=m Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.1.20 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21635241&form=6&db=m Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.1.20 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22700220&form=6&db=m Adenosine dysfunction in epilepsy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.7.1.20 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25231174&form=6&db=m Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.1.20 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32243580&form=6&db=m Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.1.20 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26329539&form=6&db=m Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.1.20 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24579775&form=6&db=m Glomerulopathy in adult recipients of pediatric kidneys. therapeutic application,unassigned 1,0 2.7.1.20 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28468960&form=6&db=m Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ?-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. unassigned - 2.7.1.20 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29017999&form=6&db=m Erratum. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic ?-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance. Diabetes 2017;66:1928-1938. unassigned - 2.7.1.20 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=175981&form=6&db=m Erythrocyte adenosine kinase activity in gout. diagnostic usage,ongoing research,unassigned 1,2,0 2.7.1.20 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21846498&form=6&db=m Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss. therapeutic application,unassigned 1,0 2.7.1.20 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31525084&form=6&db=m Adenosine Kinase Inhibition Augments Conducted Vasodilation and Prevents Left Ventricle Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction. therapeutic application,unassigned 2,0 2.7.1.20 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32352607&form=6&db=m Adenosine kinase inhibition enhances microvascular dilator function and improves left ventricle diastolic dysfunction. therapeutic application,unassigned 3,0 2.7.1.20 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27903722&form=6&db=m Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.1.20 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18644717&form=6&db=m Effects of the aryl linker and the aromatic substituent on the anti-HCV activities of aryl diketoacid (ADK) analogues. causal interaction,therapeutic application,unassigned 1,2,0 2.7.1.20 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29404478&form=6&db=m Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor ?. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.7.1.20 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29404478&form=6&db=m Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor ?. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.7.1.20 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32257606&form=6&db=m Kinases: Understanding Their Role in HIV Infection. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32762399&form=6&db=m A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. causal interaction,unassigned 1,0 2.7.1.20 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34054547&form=6&db=m Metabolic Aspects of Adenosine Functions in the Brain. ongoing research,unassigned 2,0 2.7.1.20 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9520238&form=6&db=m Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat. ongoing research,therapeutic application,unassigned 3,2,0 2.7.1.20 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9932716&form=6&db=m An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain. ongoing research,therapeutic application,unassigned 4,4,0 2.7.1.20 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10611432&form=6&db=m Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. ongoing research,therapeutic application,unassigned 4,2,0 2.7.1.20 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11160637&form=6&db=m Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action. ongoing research,therapeutic application,unassigned 3,2,0 2.7.1.20 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11423084&form=6&db=m A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats. therapeutic application,unassigned 1,0 2.7.1.20 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12151032&form=6&db=m Comparison of the ability of adenosine kinase inhibitors and adenosine receptor agonists to attenuate thermal hyperalgesia and reduce motor performance in rats. therapeutic application,unassigned 3,0 2.7.1.20 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15140630&form=6&db=m Pharmacological characterization of the chronic constriction injury model of neuropathic pain. therapeutic application,unassigned 1,0 2.7.1.20 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23840723&form=6&db=m Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system. diagnostic usage,ongoing research,unassigned 3,4,0 2.7.1.20 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223861&form=6&db=m Adenosine deaminase: functional implications and different classes of inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.7.1.20 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7596349&form=6&db=m Hyperthyroidism increases adenosine transport and metabolism in the rat heart. therapeutic application,unassigned 1,0 2.7.1.20 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26642971&form=6&db=m Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9435554&form=6&db=m Adenosine kinase inhibitor GP515 attenuates hepatic leukocyte adhesion after hemorrhagic hypotension. ongoing research,therapeutic application,unassigned 4,4,0 2.7.1.20 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2549978&form=6&db=m Changes in the activities of adenosine-metabolizing enzymes in six regions of the rat brain on chemical induction of hypothyroidism. causal interaction,unassigned 1,0 2.7.1.20 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2822032&form=6&db=m Enzymes involved in adenosine metabolism in rat white and brown adipocytes. Effects of streptozotocin-diabetes, hypothyroidism, age and sex differences. diagnostic usage,ongoing research,unassigned 1,1,0 2.7.1.20 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8981476&form=6&db=m Pre- and peristroke treatment with the adenosine kinase inhibitor, 5'-deoxyiodotubercidin, significantly reduces infarct volume after temporary occlusion of the middle cerebral artery in rats. ongoing research,therapeutic application,unassigned 1,4,0 2.7.1.20 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9059845&form=6&db=m Adenosine kinase inhibition protects brain against transient focal ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.1.20 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731623&form=6&db=m Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685255&form=6&db=m Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. causal interaction,ongoing research,unassigned 4,3,0 2.7.1.20 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17119544&form=6&db=m Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants. ongoing research,unassigned 4,0 2.7.1.20 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17457365&form=6&db=m Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism. ongoing research,therapeutic application,unassigned 4,1,0 2.7.1.20 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21427729&form=6&db=m Adenosine kinase determines the degree of brain injury after ischemic stroke in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4 2.7.1.20 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12879903&form=6&db=m Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent. unassigned - 2.7.1.20 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18596098&form=6&db=m Viral genome methylation as an epigenetic defense against geminiviruses. therapeutic application,unassigned 1,0 2.7.1.20 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26903285&form=6&db=m Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis. causal interaction,therapeutic application,unassigned 1,4,0 2.7.1.20 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32169487&form=6&db=m Immunogenicity and protective response induced by recombinant Brucella abortus proteins Adk, SecB and combination of these two recombinant proteins against a virulent strain B. abortus 544 infection in BALB/c mice. ongoing research,therapeutic application,unassigned 1,4,0 2.7.1.20 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324223&form=6&db=m Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities. therapeutic application,unassigned 2,0 2.7.1.20 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11123368&form=6&db=m Adenosine kinase inhibitor GP515 improves experimental colitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.7.1.20 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31189131&form=6&db=m Endothelial adenosine kinase deficiency ameliorates diet-induced insulin resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.1.20 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30771478&form=6&db=m Whole exome sequencing revealed mutations in FBXL4, UNC80, and ADK in Thai patients with severe intellectual disabilities. causal interaction,unassigned 4,0 2.7.1.20 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21427729&form=6&db=m Adenosine kinase determines the degree of brain injury after ischemic stroke in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4 2.7.1.20 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33249096&form=6&db=m "Adenosine an old player with new possibilities in kidney diseases": Preclinical evidences and clinical perspectives. unassigned - 2.7.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=116697&form=6&db=m Enzymes of the purine interconversion system in chronic lymphatic leukemia: decreased purine nucleoside phosphorylase and adenosine deaminase activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.1.20 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3943084&form=6&db=m Biochemical mode of cytotoxic action of neplanocin A in L1210 leukemic cells. diagnostic usage,unassigned 3,0 2.7.1.20 Leukemia L1210 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7942266&form=6&db=m Use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs. ongoing research,therapeutic application,unassigned 3,1,0 2.7.1.20 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=116697&form=6&db=m Enzymes of the purine interconversion system in chronic lymphatic leukemia: decreased purine nucleoside phosphorylase and adenosine deaminase activity. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.7.1.20 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6406772&form=6&db=m Enzymological studies in chronic lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.7.1.20 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3023350&form=6&db=m Inhibition of adenosine and thymidylate kinases by bisubstrate analogs. unassigned - 2.7.1.20 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27903722&form=6&db=m Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.1.20 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309011&form=6&db=m Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.1.20 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34347214&form=6&db=m S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver. causal interaction,therapeutic application,unassigned 3,1,0 2.7.1.20 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30944910&form=6&db=m Adenosine Kinase Deficiency Increases Susceptibility to a Carcinogen. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.7.1.20 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26491864&form=6&db=m Inhibition of Adenosine Kinase Attenuates Acute Lung Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.1.20 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18726651&form=6&db=m Prediction of lymph node status in superficial esophageal carcinoma. diagnostic usage,therapeutic application,unassigned 2,1,0 2.7.1.20 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20022091&form=6&db=m Adenocarcinoma versus urothelial carcinoma of the urinary bladder: comparison between pathologic stage at radical cystectomy and cancer-specific mortality. diagnostic usage,therapeutic application,unassigned 2,1,0 2.7.1.20 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835956&form=6&db=m Adenosine kinase deficiency in tritiated deoxyadenosine-resistant mouse S49 lymphoma cell lines. causal interaction,unassigned 2,0 2.7.1.20 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6202772&form=6&db=m Effects of deoxycoformycin in mice. II. Differences between the drug sensitivities and purine metabolizing enzymes of transplantable lymphomas of varying immunologic phenotypes. diagnostic usage,unassigned 3,0 2.7.1.20 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6428410&form=6&db=m Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells. causal interaction,ongoing research,unassigned 2,2,0 2.7.1.20 Lymphoproliferative Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223861&form=6&db=m Adenosine deaminase: functional implications and different classes of inhibitors. causal interaction,therapeutic application,unassigned 3,1,0 2.7.1.20 Malformations of Cortical Development http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25575137&form=6&db=m Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.1.20 Malocclusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25865538&form=6&db=m Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion. therapeutic application,unassigned 1,0 2.7.1.20 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21552873&form=6&db=m Nucleotide-metabolism and chromosome alterations in human-malignant melanoma xenografts. causal interaction,diagnostic usage,unassigned 1,3,0 2.7.1.20 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28882690&form=6&db=m Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells. causal interaction,unassigned 1,0 2.7.1.20 Melioidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20331978&form=6&db=m Structural characterization of Burkholderia pseudomallei adenylate kinase (Adk): profound asymmetry in the crystal structure of the 'open' state. therapeutic application,unassigned 1,0 2.7.1.20 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22521820&form=6&db=m Working memory and the homeostatic control of brain adenosine by adenosine kinase. unassigned - 2.7.1.20 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22706302&form=6&db=m Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia. ongoing research,unassigned 4,0 2.7.1.20 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309011&form=6&db=m Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.1.20 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23585020&form=6&db=m Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-?-riboside-induced apoptosis in multiple myeloma cells. unassigned - 2.7.1.20 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28504647&form=6&db=m Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.1.20 Muscle Hypotonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26993811&form=6&db=m MRI and (1)H-MRS in adenosine kinase deficiency. causal interaction,unassigned 4,0 2.7.1.20 Muscle Hypotonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30477030&form=6&db=m Adenosine Kinase Deficiency: Report and Review. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15795795&form=6&db=m Cardioprotection following adenosine kinase inhibition in rat hearts. ongoing research,therapeutic application,unassigned 4,1,0 2.7.1.20 Myoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33817738&form=6&db=m Unexpected location of endometrial adenocarcinoma - a case report. diagnostic usage,unassigned 2,0 2.7.1.20 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18726651&form=6&db=m Prediction of lymph node status in superficial esophageal carcinoma. diagnostic usage,therapeutic application,unassigned 2,1,0 2.7.1.20 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20022091&form=6&db=m Adenocarcinoma versus urothelial carcinoma of the urinary bladder: comparison between pathologic stage at radical cystectomy and cancer-specific mortality. diagnostic usage,therapeutic application,unassigned 2,1,0 2.7.1.20 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25263945&form=6&db=m Diverticular disease and colon cancer: a real association between the two diseases? unassigned - 2.7.1.20 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921385&form=6&db=m Dysregulation of adenosine kinase isoforms in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.1.20 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32239119&form=6&db=m A rare case of synchronous ovarian tumors: clinical case report and literature review. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.1.20 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33102037&form=6&db=m Fronto-orbital metastasis of a prostatic adenocarcinoma. causal interaction,unassigned 4,0 2.7.1.20 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33294440&form=6&db=m Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.1.20 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34142286&form=6&db=m Optimal Treatment of cT2N0 Esophageal Carcinoma: Is Upfront Surgery Really the Way? causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=174138&form=6&db=m Feedback inhibition by 6-methylthioinosine 3',5'-cyclic monophosphate in tumor cells resistant to the nucleoside. unassigned - 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=207296&form=6&db=m Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,2 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154328&form=6&db=m Purine metabolism of human glioblastoma in vivo. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3087122&form=6&db=m [Delayed hypersensitivity and nonspecific cellular immunity. The cytotoxic activity of macrophages, natural and antibody-dependent killer cells] causal interaction,therapeutic application,unassigned 1,2,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3494546&form=6&db=m Studies on the mechanism of cytotoxicity of 3'-deoxyadenosine N1-oxide in different strains of Ehrlich ascites tumor cells. unassigned - 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5062817&form=6&db=m Kinetic studies of adenosine kinase from Ehrlich ascites tumor cells. diagnostic usage,ongoing research,unassigned 3,1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6024304&form=6&db=m Purification and properties of adenosine kinase from human tumor cells of type H. Ep. No. 2. ongoing research,unassigned 4,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9205063&form=6&db=m The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. causal interaction,therapeutic application,unassigned 2,4,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11999115&form=6&db=m Protein expression during lag phase and growth initiation in Saccharomyces cerevisiae. unassigned - 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12817886&form=6&db=m A rational approach to personalized anticancer therapy: chemoinformatic analysis reveals mechanistic gene-drug associations. unassigned - 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17185918&form=6&db=m [Adenocarcinomas of the ethmoid sinus: retrospective analysis of prognostic factors] diagnostic usage,unassigned 2,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18600536&form=6&db=m Adenosine kinase gene expression in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20714754&form=6&db=m Animal models of the cancer anorexia-cachexia syndrome. ongoing research,unassigned 3,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22092111&form=6&db=m Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy. causal interaction,unassigned 4,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23592612&form=6&db=m Adenosine kinase: exploitation for therapeutic gain. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23937241&form=6&db=m Vascular endothelial growth factor (VEGF) expression and microvascular density in salivary gland tumours. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26329539&form=6&db=m Adenosine deaminase and adenosine kinase expression in human glioma and their correlation with glioma?associated epilepsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743291&form=6&db=m Ki-67 and p53 immunostaining assessment of proliferative activity in salivary tumors. diagnostic usage,unassigned 2,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26983602&form=6&db=m Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury. therapeutic application,unassigned 1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27812320&form=6&db=m Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28504647&form=6&db=m Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29468700&form=6&db=m Cancer cells govern miR-2909 exosomal recruitment through its 3'-end post-transcriptional modification. causal interaction,unassigned 1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30755485&form=6&db=m 5'-Iodotubercidin represses insulinoma associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30944910&form=6&db=m Adenosine Kinase Deficiency Increases Susceptibility to a Carcinogen. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921385&form=6&db=m Dysregulation of adenosine kinase isoforms in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32239119&form=6&db=m A rare case of synchronous ovarian tumors: clinical case report and literature review. causal interaction,diagnostic usage,unassigned 3,3,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32317394&form=6&db=m Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia. ongoing research,unassigned 1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32434943&form=6&db=m Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal. therapeutic application,unassigned 1,0 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33860193&form=6&db=m Adenosine Kinase Expression Determines DNA Methylation in Cancer Cell Lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,3 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34033870&form=6&db=m Adenosine Inhibits Cell Proliferation Differently in Human Astrocytes and in Glioblastoma Cell Lines. unassigned - 2.7.1.20 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34142286&form=6&db=m Optimal Treatment of cT2N0 Esophageal Carcinoma: Is Upfront Surgery Really the Way? causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.7.1.20 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22997174&form=6&db=m Homeostatic Control of Synaptic Activity by Endogenous Adenosine is Mediated by Adenosine Kinase. therapeutic application,unassigned 4,0 2.7.1.20 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33309011&form=6&db=m Adenosine kinase deficiency: Three new cases and diagnostic value of hypermethioninemia. causal interaction,diagnostic usage,unassigned 4,4,0 2.7.1.20 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33496919&form=6&db=m Computational exploration of vicine - an alkaloid glycoside mediated pathological hallmark of adenosine kinase to promote neurological disorder. ongoing research,therapeutic application,unassigned 2,2,0 2.7.1.20 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9932716&form=6&db=m An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain. ongoing research,therapeutic application,unassigned 4,4,0 2.7.1.20 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25414036&form=6&db=m Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. therapeutic application,unassigned 3,0 2.7.1.20 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6246950&form=6&db=m Adenosine transport by a variant of C1300 murine neuroblastoma cells deficient in adenosine kinase. ongoing research,unassigned 1,0 2.7.1.20 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9600645&form=6&db=m Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34054547&form=6&db=m Metabolic Aspects of Adenosine Functions in the Brain. ongoing research,unassigned 2,0 2.7.1.20 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26332308&form=6&db=m Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.7.1.20 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30927276&form=6&db=m Pathway genes and metabolites in thiopurine therapy in Korean children with acute lymphoblastic leukaemia. therapeutic application,unassigned 1,0 2.7.1.20 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22422370&form=6&db=m Obesity and diabetes: Adenosine kinase inhibitor increases ?-cells. causal interaction,unassigned 2,0 2.7.1.20 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25457840&form=6&db=m Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy. causal interaction,therapeutic application,unassigned 4,2,0 2.7.1.20 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29696223&form=6&db=m The effect of negative randomized trials and surgeon volume on the rates of arthroscopy for patients with knee OA. unassigned - 2.7.1.20 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29404478&form=6&db=m Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor ?. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.7.1.20 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32762399&form=6&db=m A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. causal interaction,unassigned 1,0 2.7.1.20 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29126171&form=6&db=m Copy number variant in the region of adenosine kinase (ADK) and its possible contribution to schizophrenia susceptibility. causal interaction,unassigned 4,0 2.7.1.20 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11264257&form=6&db=m The effect of ABT-702, a novel adenosine kinase inhibitor, on the responses of spinal neurones following carrageenan inflammation and peripheral nerve injury. ongoing research,therapeutic application,unassigned 2,3,0 2.7.1.20 Peritoneal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25263945&form=6&db=m Diverticular disease and colon cancer: a real association between the two diseases? unassigned - 2.7.1.20 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26491864&form=6&db=m Inhibition of Adenosine Kinase Attenuates Acute Lung Injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.7.1.20 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14586729&form=6&db=m Carbonic adsorbent AST-120 retards progression of renal failure by additive effect with ACEI and protein restriction diet. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0 2.7.1.20 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324223&form=6&db=m Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities. therapeutic application,unassigned 2,0 2.7.1.20 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9296430&form=6&db=m The effect of GP683, an adenosine kinase inhibitor, on the desflurane anesthetic requirement in dogs. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Sarcoma 180 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5169930&form=6&db=m Adenosine kinase of sarcoma 180 cells N 6 -substituted adenosines as substrates and inhibitors. therapeutic application,unassigned 4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8450475&form=6&db=m Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility. causal interaction,therapeutic application,unassigned 2,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8804908&form=6&db=m Potentiation of excitatory amino acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9600645&form=6&db=m Co-administration of adenosine kinase and deaminase inhibitors produces supra-additive potentiation of N-methyl-D-aspartate-evoked adenosine formation in cortex. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14736855&form=6&db=m Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15050645&form=6&db=m Discovery and optimization of 2-aryl oxazolo-pyrimidines as adenosine kinase inhibitors using liquid phase parallel synthesis. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632276&form=6&db=m Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies. therapeutic application,unassigned 3,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817264&form=6&db=m Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts. ongoing research,unassigned 2,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930047&form=6&db=m Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16709437&form=6&db=m The support of adenosine release from adenosine kinase deficient ES cells by silk substrates. unassigned - 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16846657&form=6&db=m Modulatory role of adenosine and its receptors in epilepsy: Possible therapeutic approaches. therapeutic application,unassigned 4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16859834&form=6&db=m Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. causal interaction,unassigned 1,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056128&form=6&db=m Adenosine kinase, epilepsy and stroke: mechanisms and therapies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17716659&form=6&db=m Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control. ongoing research,unassigned 3,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18172552&form=6&db=m Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18249058&form=6&db=m The adenosine kinase hypothesis of epileptogenesis. unassigned - 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18634566&form=6&db=m Adenosine dysfunction in astrogliosis: cause for seizure generation? causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18957298&form=6&db=m Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus. therapeutic application,unassigned 1,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19332320&form=6&db=m Engineered adenosine-releasing cells for epilepsy therapy: human mesenchymal stem cells and human embryonic stem cells. causal interaction,ongoing research,unassigned 3,2,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19674507&form=6&db=m Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice. causal interaction,unassigned 2,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19682439&form=6&db=m Therapeutic epilepsy research: From pharmacological rationale to focal adenosine augmentation. causal interaction,unassigned 3,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20633035&form=6&db=m Inhibitory RNA in epilepsy: research tools and therapeutic perspectives. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20730044&form=6&db=m Adenosine dysfunction and adenosine kinase in epileptogenesis. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21275977&form=6&db=m Adenosine kinase as a target for therapeutic antisense strategies in epilepsy. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21701073&form=6&db=m Adenosine: front and center in linking nutrition and metabolism to neuronal activity. causal interaction,unassigned 2,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21964979&form=6&db=m Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis? therapeutic application,unassigned 1,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22092111&form=6&db=m Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy. causal interaction,unassigned 4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22700220&form=6&db=m Adenosine dysfunction in epilepsy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24251559&form=6&db=m The antiepileptic potential of nucleosides. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25231174&form=6&db=m Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25979489&form=6&db=m Comorbidities in Neurology: Is adenosine the common link? ongoing research,unassigned 1,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26040919&form=6&db=m Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27410258&form=6&db=m South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase. causal interaction,therapeutic application,unassigned 2,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27903722&form=6&db=m Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27915186&form=6&db=m Role of the purinergic signaling in epilepsy. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789481&form=6&db=m Upregulation of Neuronal Adenosine A1 Receptor in Human Rasmussen Encephalitis. causal interaction,therapeutic application,unassigned 4,1,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30468847&form=6&db=m The role of adenosine in epilepsy. unassigned - 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30862176&form=6&db=m Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures. therapeutic application,unassigned 2,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31633474&form=6&db=m Role of Adenosine Kinase Inhibitor in Adenosine Augmentation Therapy for Epilepsy: A Potential Novel Drug for Epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31779529&form=6&db=m Discovery and identification of putative adenosine kinase inhibitors as potential anti-epileptic agents from structural insights. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679397&form=6&db=m Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy. causal interaction,unassigned 3,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33496919&form=6&db=m Computational exploration of vicine - an alkaloid glycoside mediated pathological hallmark of adenosine kinase to promote neurological disorder. ongoing research,therapeutic application,unassigned 2,2,0 2.7.1.20 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34479194&form=6&db=m Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1 2.7.1.20 Sexually Transmitted Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944444&form=6&db=m Population genetics of Neisseria gonorrhoeae in a high-prevalence community using a hypervariable outer membrane porB and 13 slowly evolving housekeeping genes. ongoing research,unassigned 2,0 2.7.1.20 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207212&form=6&db=m Protective effect of an adenosine kinase inhibitor in septic shock. ongoing research,therapeutic application,unassigned 3,4,0 2.7.1.20 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12675911&form=6&db=m Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. diagnostic usage,unassigned 1,0 2.7.1.20 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=199954&form=6&db=m The control of cell proliferation by preformed purines: a genetic study. I. Isolation and preliminary characterization of Chinese hamster lines with single or multiple defects in purine "salvage" pathways. causal interaction,unassigned 2,0 2.7.1.20 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3014311&form=6&db=m AMP deaminase in Dictyostelium discoideum: increase in activity following nutrient deprivation induced by starvation or hadacidin. causal interaction,ongoing research,unassigned 1,1,0 2.7.1.20 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17878054&form=6&db=m Adenosine uptake-dependent C6 cell growth inhibition. unassigned - 2.7.1.20 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930047&form=6&db=m Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 2.7.1.20 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17716659&form=6&db=m Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control. ongoing research,unassigned 3,0 2.7.1.20 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21635241&form=6&db=m Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.7.1.20 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056128&form=6&db=m Adenosine kinase, epilepsy and stroke: mechanisms and therapies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2 2.7.1.20 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17457365&form=6&db=m Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism. ongoing research,therapeutic application,unassigned 4,1,0 2.7.1.20 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537672&form=6&db=m Modulation of ischemic brain injury and neuroinflammation by adenosine A2A receptors. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21427729&form=6&db=m Adenosine kinase determines the degree of brain injury after ischemic stroke in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4 2.7.1.20 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24089624&form=6&db=m Adenosine kinase is a new therapeutic target to prevent ischemic neuronal death. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 2.7.1.20 Sudden Unexpected Death in Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32243580&form=6&db=m Adenosine kinase and adenosine receptors A1 R and A2A R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.7.1.20 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324223&form=6&db=m Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities. therapeutic application,unassigned 2,0 2.7.1.20 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15055998&form=6&db=m Synthesis, biological activity and molecular modeling of 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Tremor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9865523&form=6&db=m Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation. causal interaction,therapeutic application,unassigned 2,1,0 2.7.1.20 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921385&form=6&db=m Dysregulation of adenosine kinase isoforms in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398370&form=6&db=m A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study. ongoing research,unassigned 3,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594827&form=6&db=m Identification and characterization of a unique adenosine kinase from Mycobacterium tuberculosis. ongoing research,unassigned 4,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15207808&form=6&db=m Metabolism of 2-methyladenosine in Mycobacterium tuberculosis. unassigned - 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16511094&form=6&db=m Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16620788&form=6&db=m Structure-activity relationship for nucleoside analogs as inhibitors or substrates of adenosine kinase from Mycobacterium tuberculosis. I. Modifications to the adenine moiety. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17085766&form=6&db=m Evaluation of 3-deaza-adenosine analogues as ligands for adenosine kinase and inhibitors of Mycobacterium tuberculosis growth. ongoing research,therapeutic application,unassigned 2,4,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17346177&form=6&db=m Purine metabolism in Mycobacterium tuberculosis as a target for drug development. causal interaction,unassigned 1,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17597075&form=6&db=m High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme. causal interaction,unassigned 1,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18329005&form=6&db=m Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety. ongoing research,therapeutic application,unassigned 3,2,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25259627&form=6&db=m Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides. ongoing research,unassigned 1,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25882678&form=6&db=m 2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity. therapeutic application,unassigned 1,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31002508&form=6&db=m Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase. therapeutic application,unassigned 4,0 2.7.1.20 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31199855&form=6&db=m Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase. therapeutic application,unassigned 1,0 2.7.1.20 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2449123&form=6&db=m 9-(trans-2',trans-3'-Dihydroxycyclopent-4'-enyl)-adenine and -3-deazaadenine: analogs of neplanocin A which retain potent antiviral activity but exhibit reduced cytotoxicity. therapeutic application,unassigned 2,0 2.7.1.20 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32065618&form=6&db=m Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32533148&form=6&db=m Therapeutic potential of adenosine kinase inhibition in vascular disease. causal interaction,therapeutic application,unassigned 4,4,0 2.7.1.20 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32065618&form=6&db=m Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation. causal interaction,therapeutic application,unassigned 3,4,0 2.7.1.20 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8281944&form=6&db=m Structural and physico-chemical characteristics of Bordetella pertussis adenylate kinase, a tryptophan-containing enzyme. ongoing research,therapeutic application,unassigned 1,2,0