2.3.1.39 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173288&form=6&db=m Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19358283&form=6&db=m Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523670&form=6&db=m In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22490687&form=6&db=m [Effects of soluble epoxide hydrolase inhibitors on the expression of fatty acid synthase in peripheral blood mononuclear cell of patients and inflammatory response with acute coronary syndrome]. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23305094&form=6&db=m Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.39 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31287803&form=6&db=m Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6130760&form=6&db=m Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11176534&form=6&db=m Fatty acid synthase: an early molecular marker of progression of prostatic adenocarcinoma to androgen independence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15051923&form=6&db=m Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15094777&form=6&db=m Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16084671&form=6&db=m Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft function. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16564913&form=6&db=m Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809439&form=6&db=m Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators? causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18802406&form=6&db=m Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19471962&form=6&db=m Evaluation of fatty acid synthase expression in oesophageal mucosa of patients with oesophagitis, Barrett's oesophagus and adenocarcinoma. diagnostic usage,ongoing research,unassigned 3,1,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21757596&form=6&db=m Is there a role for fatty acid synthase in the diagnosis of prostatic adenocarcinoma?: A comparison with AMACR. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801966&form=6&db=m Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22585994&form=6&db=m MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 2.3.1.39 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622804&form=6&db=m A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.39 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400509&form=6&db=m Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32438613&form=6&db=m Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632348&form=6&db=m Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.39 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11903600&form=6&db=m Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.39 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12170454&form=6&db=m P53 as a marker of differentiation between hyperplastic and adenomatous parathyroids. diagnostic usage,therapeutic application,unassigned 2,1,0 2.3.1.39 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19358283&form=6&db=m Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30597641&form=6&db=m Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.39 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20701095&form=6&db=m Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21385214&form=6&db=m Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.39 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863221&form=6&db=m CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease. ongoing research,unassigned 2,0 2.3.1.39 Ameloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692057&form=6&db=m Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239908&form=6&db=m Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885322&form=6&db=m The double dealing of cyclin D1. therapeutic application,unassigned 1,0 2.3.1.39 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29775891&form=6&db=m Protective effect of atorvastatin meditated by HMGCR gene on diabetic rats with atherosclerosis: An in vivo and in vitro study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31353547&form=6&db=m Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. causal interaction,unassigned 1,0 2.3.1.39 Azotemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19357177&form=6&db=m Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney. ongoing research,unassigned 1,0 2.3.1.39 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21325951&form=6&db=m Fatty Acid Synthase Expression in Barrett's Esophagus: Implications for Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.39 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321376&form=6&db=m Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. therapeutic application,unassigned 1,0 2.3.1.39 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33918393&form=6&db=m MCAT Mutations Cause Nuclear LHON-like Optic Neuropathy. unassigned - 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8022791&form=6&db=m Fatty acid synthesis: a potential selective target for antineoplastic therapy. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630954&form=6&db=m Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10228495&form=6&db=m Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493979&form=6&db=m Fatty acid synthase expression in Japanese breast carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737707&form=6&db=m Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11323104&form=6&db=m Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11384102&form=6&db=m Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11444828&form=6&db=m Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11447743&form=6&db=m Immunohistochemical expression of human erythrocyte glucose transporter and fatty acid synthase in infiltrating breast carcinomas and adjacent typical/atypical hyperplastic or normal breast tissue. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11935210&form=6&db=m Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12517789&form=6&db=m Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. diagnostic usage,unassigned 3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12531699&form=6&db=m Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12654184&form=6&db=m [Inhibition of triclosan to fatty acid synthase from goose uropygial glands and human breast cancer cells in vitro] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12931129&form=6&db=m Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. ongoing research,unassigned 4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999148&form=6&db=m Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/ neu -overexpressing human breast cancer cells to docetaxel (taxotere). causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15094777&form=6&db=m Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254710&form=6&db=m Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358634&form=6&db=m Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15390078&form=6&db=m Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15489885&form=6&db=m Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15500005&form=6&db=m Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15577743&form=6&db=m Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells. diagnostic usage,unassigned 2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15583825&form=6&db=m RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells. unassigned - 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15780499&form=6&db=m Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870863&form=6&db=m The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247515&form=6&db=m Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer. ongoing research,therapeutic application,unassigned 2,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16404708&form=6&db=m Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. unassigned - 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740734&form=6&db=m Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809439&form=6&db=m Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators? causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16886624&form=6&db=m Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17044016&form=6&db=m Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17089011&form=6&db=m DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17182072&form=6&db=m Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling. ongoing research,unassigned 4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17352212&form=6&db=m MRNA stability and overexpression of fatty acid synthase in human breast cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413110&form=6&db=m Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China. causal interaction,unassigned 3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17488603&form=6&db=m [Transcriptional activities of human fatty acid synthase promoter in breast cancer cells] diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17539658&form=6&db=m Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. ongoing research,unassigned 3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17565694&form=6&db=m Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17631500&form=6&db=m Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653900&form=6&db=m A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786307&form=6&db=m Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786362&form=6&db=m Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18022396&form=6&db=m Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18211286&form=6&db=m Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. unassigned - 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281512&form=6&db=m A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18359695&form=6&db=m [Expression of epidermal fatty acid-binding protein and fatty acid synthase in infiltrating ductal breast carcinoma.] diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18798507&form=6&db=m [Gene expression of H-FABP and FAS and its clinicopathological significance in breast infiltrating ductal carcinoma] diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18820672&form=6&db=m Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19083124&form=6&db=m Aromatase, CYP1B1 and Fatty Acid Synthase Expression in Breast Tumors of BRCA1 Mutation Carriers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116881&form=6&db=m Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19652385&form=6&db=m Fatty acid synthase inhibition by amentoflavone induces apoptosis and antiproliferation in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19885560&form=6&db=m Fatty acid synthase activity regulates HER2 extracellular domain shedding into the circulation of HER2-positive metastatic breast cancer patients. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20008854&form=6&db=m Novel Inhibitors of Fatty Acid Synthase with Anticancer Activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20218616&form=6&db=m Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20356977&form=6&db=m Hyperglycemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20531416&form=6&db=m Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20665104&form=6&db=m Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20973802&form=6&db=m Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21080941&form=6&db=m Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21194113&form=6&db=m The anti-cancer effects of (-)-epigalocathine-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21767081&form=6&db=m Inhibition of Fatty Acid synthase and sp1 expression by 3,3'-diindolylmethane in human breast cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21792929&form=6&db=m The anti-cancer effects of (-)-Epigalocathine-3-gallate on the signaling pathways associated with membrane receptors in MCF-7 cells. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22177475&form=6&db=m A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22767439&form=6&db=m Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23142364&form=6&db=m Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23317220&form=6&db=m Inhibitory effects of onion (Allium cepa L.) extract on proliferation of cancer cells and adipocytes via inhibiting fatty acid synthase. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23982110&form=6&db=m Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24362821&form=6&db=m Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24520215&form=6&db=m Fatty acid synthase mediates the epithelial-mesenchymal transition of breast cancer cells. ongoing research,unassigned 4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24866893&form=6&db=m The mTOR inhibitor rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24894151&form=6&db=m Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24957042&form=6&db=m Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25292037&form=6&db=m Mechanism of fatty acid synthase in drug tolerance related to epithelial-mesenchymal transition of breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25442282&form=6&db=m Effects of anti-proliferative lichen metabolite, protolichesterinic acid on fatty acid synthase, cell signalling and drug response in breast cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25448084&form=6&db=m Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25924435&form=6&db=m [Expression of fatty acid synthase and adipocyte fatty acid-binding protein and the relationship with the clinicopathological characteristics in human infiltrating ductal breast cancer]. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25975007&form=6&db=m Dietary fatty acids affect lipid metabolism and estrogen receptor expression in N-methyl-N-nitrosourea-induced rat mammary cancer model. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26107737&form=6&db=m Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity against breast cancer models resistant to anti-HER2 drugs. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26349913&form=6&db=m Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484401&form=6&db=m Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26544947&form=6&db=m Application of chromatography technology in the separation of active alkaloids from Hypecoum leptocarpum and their inhibitory effect on fatty acid synthase. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26647383&form=6&db=m Hyperglycaemia-induced chemoresistance in breast cancer cells: role of the estrogen receptor. ongoing research,unassigned 1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26936618&form=6&db=m FASN, ErbB2-mediated glycolysis is required for breast cancer cell migration. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26985864&form=6&db=m Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27223424&form=6&db=m Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270654&form=6&db=m Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27291048&form=6&db=m 1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27579768&form=6&db=m Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase. ongoing research,unassigned 3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713175&form=6&db=m Fatty acid synthase is a primary target of MiR-15a and MiR-16-1 in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713913&form=6&db=m The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27714708&form=6&db=m Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28119133&form=6&db=m Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids. ongoing research,unassigned 2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28240737&form=6&db=m Fatty acid synthase regulates estrogen receptor-? signaling in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386750&form=6&db=m Fatty acid synthase regulates the chemosensitivity of breast cancer cells to cisplatin-induced apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28427229&form=6&db=m NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28922023&form=6&db=m Fatty acid synthase (FASN) as a therapeutic target in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29031197&form=6&db=m Mitochondrial dysfunction is responsible for fatty acid synthase inhibition-induced apoptosis in breast cancer cells by PdpaMn. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088813&form=6&db=m Hypoxia negates hyperglycaemia-induced chemo-resistance in breast cancer cells: the role of insulin-like growth factor binding protein 2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29113229&form=6&db=m Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29282029&form=6&db=m Docosahexaenoic acid reduces sterol regulatory element binding protein-1 and fatty acid synthase expression and inhibits cell proliferation by inhibiting pAkt signaling in a human breast cancer MCF-7 cell line. ongoing research,unassigned 4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29344187&form=6&db=m Patuletin induces apoptosis of human breast cancer SK-BR-3 cell line via inhibiting fatty acid synthase gene expression and activity. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29751678&form=6&db=m (-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30478149&form=6&db=m 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers. ongoing research,unassigned 3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30538543&form=6&db=m Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30741424&form=6&db=m Antitumor effects of curcumin: A lipid perspective. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31030489&form=6&db=m Thymoquinone Augments Cyclophosphamide-Mediated Inhibition of Cell Proliferation in Breast Cancer Cells diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31164796&form=6&db=m Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31497225&form=6&db=m Vitisin B as a novel fatty acid synthase inhibitor induces human breast cancer cells apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32649369&form=6&db=m PdpaMn inhibits fatty acid synthase-mediated glycolysis by down-regulating PI3K/Akt signaling pathway in breast cancer. therapeutic application,unassigned 1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32698885&form=6&db=m Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801705&form=6&db=m Fatty Acid Synthase (FASN) siRNA-Encapsulated-Her-2 Targeted Fab'-Immunoliposomes for Gene Silencing in Breast Cancer Cells. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32899149&form=6&db=m In Situ Metabolic Characterisation of Breast Cancer and Its Potential Impact on Therapy. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33081219&form=6&db=m Fatty Acid Synthase Is a Key Enabler for Endocrine Resistance in Heregulin-Overexpressing Luminal B-Like Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33226729&form=6&db=m Autophagy activation and SREBP-1 induction contribute to fatty acid metabolic reprogramming by leptin in breast cancer cells. unassigned - 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33240433&form=6&db=m Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33335078&form=6&db=m Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33745568&form=6&db=m Serum fatty acid synthase levels and n-3 fatty acid intake in patients with breast cancer. diagnostic usage,ongoing research,unassigned 2,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33780787&form=6&db=m Virtual screening-based identification of novel fatty acid synthase inhibitor and evaluation of its antiproliferative activity in breast cancer cells. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33800852&form=6&db=m Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33813001&form=6&db=m Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase. therapeutic application,unassigned 4,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33837062&form=6&db=m Breast Cancer Brain Metastases Rely on FASN-Mediated Lipid Biosynthesis. diagnostic usage,unassigned 1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33961924&form=6&db=m Targeting lipid metabolism is an emerging strategy to enhance the efficacy of anti-HER2 therapies in HER2-positive breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34123778&form=6&db=m MET and FASN as Prognostic Biomarkers of Triple Negative Breast Cancer: A Systematic Evidence Landscape of Clinical Study. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179825&form=6&db=m FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.39 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34400413&form=6&db=m Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in patients with Operable TNBC. diagnostic usage,unassigned 2,0 2.3.1.39 Candidiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8828218&form=6&db=m Requirement for the Candida albicans FAS2 gene for infection in a rat model of oropharyngeal candidiasis. ongoing research,unassigned 2,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11903600&form=6&db=m Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138577&form=6&db=m Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. therapeutic application,unassigned 1,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358634&form=6&db=m Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15543204&form=6&db=m Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15609334&form=6&db=m Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17044016&form=6&db=m Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17539658&form=6&db=m Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling. ongoing research,unassigned 3,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18239060&form=6&db=m Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. causal interaction,unassigned 1,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19318631&form=6&db=m Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21325951&form=6&db=m Fatty Acid Synthase Expression in Barrett's Esophagus: Implications for Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22218925&form=6&db=m The "HER2-PI3K/Akt-FASN Axis" Regulated Malignant Phenotype of Colorectal Cancer Cells. causal interaction,unassigned 1,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22485149&form=6&db=m Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22513183&form=6&db=m Dihydroquercetin: More than just an impurity? ongoing research,therapeutic application,unassigned 1,2,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22860766&form=6&db=m Fatty Acid Synthase Regulates Proliferation and Migration of Colorectal Cancer Cells Via HER2-PI3K/Akt Signaling Pathway. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562839&form=6&db=m The fat side of prostate cancer. diagnostic usage,unassigned 4,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23725225&form=6&db=m Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells. causal interaction,unassigned 3,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25155760&form=6&db=m Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25351625&form=6&db=m LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3?kinase/Akt/fatty acid synthase signaling pathway in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270654&form=6&db=m Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29681001&form=6&db=m Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921669&form=6&db=m Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32699531&form=6&db=m Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.3.1.39 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324084&form=6&db=m Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice. ongoing research,unassigned 3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8640795&form=6&db=m Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8665507&form=6&db=m Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815604&form=6&db=m Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419158&form=6&db=m Fatty acid synthase gene expression in rat mammary carcinoma. ongoing research,unassigned 4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632348&form=6&db=m Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10716717&form=6&db=m Synthesis and antitumor activity of an inhibitor of fatty acid synthase. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11014573&form=6&db=m The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11323104&form=6&db=m Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11866947&form=6&db=m [Cerulenin inhibits growth of human colonic carcinoma in nude mice] ongoing research,unassigned 4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11903600&form=6&db=m Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12324706&form=6&db=m Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia and carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939396&form=6&db=m Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15051923&form=6&db=m Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172638&form=6&db=m Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15459486&form=6&db=m Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15543204&form=6&db=m Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15609334&form=6&db=m Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15736468&form=6&db=m Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15806173&form=6&db=m Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15920554&form=6&db=m Fatty acid synthase expression in cutaneous melanocytic neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16374067&form=6&db=m Expression of liver-type fatty-acid-binding protein, fatty acid synthase and vascular endothelial growth factor in human lung carcinoma. ongoing research,unassigned 4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778164&form=6&db=m Fatty acid synthase and cancer: new application of an old pathway. therapeutic application,unassigned 3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16969344&form=6&db=m Fatty acid synthase: a novel target for antiglioma therapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17334082&form=6&db=m [Analysis of gene expression of fatty acid synthase in squamous cell carcinoma of the oral cavity by the method of real-time quantitative PCR] diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409402&form=6&db=m Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17695548&form=6&db=m Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17825601&form=6&db=m ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: correlation with clinical outcomes. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17904792&form=6&db=m Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199615&form=6&db=m 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410580&form=6&db=m Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18528705&form=6&db=m Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18555493&form=6&db=m Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18639282&form=6&db=m Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18949744&form=6&db=m Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19189648&form=6&db=m Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268984&form=6&db=m [Fatty acid synthase: a new anti-tumor target.] unassigned - 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19358283&form=6&db=m Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362044&form=6&db=m Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20228137&form=6&db=m Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20228782&form=6&db=m Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20508725&form=6&db=m Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20604875&form=6&db=m ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20701095&form=6&db=m Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20713491&form=6&db=m HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20973802&form=6&db=m Novel anti-fatty acid synthase compounds with anti-cancer activity in HER2+ breast cancer. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21437031&form=6&db=m Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. ongoing research,unassigned 4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21442130&form=6&db=m Over Expression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and its Inhibition Potentiates Cisplatin Induced Apoptosis. causal interaction,unassigned 4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21922386&form=6&db=m Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21970855&form=6&db=m Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22554590&form=6&db=m Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,3 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22565411&form=6&db=m Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22653145&form=6&db=m Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22709911&form=6&db=m Expression Status of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22769244&form=6&db=m Different fatty acid metabolism effects of (¿)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22886728&form=6&db=m Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23142364&form=6&db=m Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226763&form=6&db=m High overexpression of fatty acid synthase is associated with poor survival in Chinese patients with gastric carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23287468&form=6&db=m The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells. unassigned - 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23419663&form=6&db=m Expression Staus of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma. causal interaction,unassigned 3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23982110&form=6&db=m Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24362464&form=6&db=m The Fatty Acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24527066&form=6&db=m Elevated levels of serum fatty acid synthase in patients with gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24643292&form=6&db=m Prognostic Impact of Fatty Acid Synthase Expression in Upper Urinary Tract Urothelial Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484401&form=6&db=m Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26718084&form=6&db=m Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho?AKT in bladder cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26951539&form=6&db=m Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27106068&form=6&db=m Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer. ongoing research,unassigned 4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28260110&form=6&db=m Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28871635&form=6&db=m Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29449607&form=6&db=m 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. unassigned - 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29751678&form=6&db=m (-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30597641&form=6&db=m Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692057&form=6&db=m Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30875891&form=6&db=m EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30950543&form=6&db=m Activation of prolyl hydroxylase-2 for stabilization of mitochondrial stress along with simultaneous downregulation of HIF-1?/FASN in ER + breast cancer subtype. causal interaction,diagnostic usage,unassigned 2,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31122252&form=6&db=m Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31154466&form=6&db=m PHD-2 activation: a novel strategy to control HIF-1? and mitochondrial stress to modulate mammary gland pathophysiology in ER+ subtype. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32103349&form=6&db=m The clinicopathological significance of the adipophilin and fatty acid synthase expression in salivary duct carcinoma. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32197133&form=6&db=m Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32239862&form=6&db=m [Effect of down-regulation of fatty acid synthase expression on proliferation, migration and invasion of bladder carcinoma UMUC3 cell lines]. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32536483&form=6&db=m Inhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the ?-catenin/C-myc signaling pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32820613&form=6&db=m Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/?-catenin pathway. unassigned - 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027752&form=6&db=m Expression and prognostic significance of fatty acid synthase in clear cell renal cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33569391&form=6&db=m Fatty Acid Synthase Correlates With Prognosis-Related Abdominal Adipose Distribution and Metabolic Disorders of Clear Cell Renal Cell Carcinoma. diagnostic usage,ongoing research,unassigned 2,4,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33843033&form=6&db=m Immunohistochemical Expression of Fatty Acid Synthase (FASN) is Correlated to Tumor Aggressiveness and Cellular Differentiation in Salivary Gland Carcinomas. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34510641&form=6&db=m FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.39 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20228782&form=6&db=m Serous tubal intraepithelial carcinoma upregulates markers associated with high-grade serous carcinomas including Rsf-1 (HBXAP), cyclin E and fatty acid synthase. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.3.1.39 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21922386&form=6&db=m Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.39 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20701095&form=6&db=m Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32820613&form=6&db=m Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/?-catenin pathway. unassigned - 2.3.1.39 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15390078&form=6&db=m Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.39 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23928534&form=6&db=m [Expression of fatty acid synthase and its association with HER2 in invasive ductal carcinoma of breast]. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.39 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29113229&form=6&db=m Fatty acid synthase affects expression of ErbB receptors in epithelial to mesenchymal transition of breast cancer cells and invasive ductal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7567999&form=6&db=m Human fatty acid synthase: properties and molecular cloning. ongoing research,unassigned 4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8567694&form=6&db=m Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP. ongoing research,unassigned 4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9644037&form=6&db=m Insulin increases fatty acid synthase gene transcription in human adipocytes. ongoing research,unassigned 4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10103003&form=6&db=m FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line. ongoing research,unassigned 3,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16855382&form=6&db=m Growth Arrest Induced by C75, A Fatty Acid Synthase Inhibitor, was Partially Modulated by p38 MAPK but Not by p53 In Human Hepatocellular Carcinoma. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16925113&form=6&db=m Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cells. ongoing research,unassigned 3,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903962&form=6&db=m Liver X receptor alpha regulates fatty acid synthase expression in chicken. ongoing research,unassigned 3,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20173757&form=6&db=m A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. causal interaction,ongoing research,unassigned 2,4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428769&form=6&db=m Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21180254&form=6&db=m Effects of retinoic acid and hydrogen peroxide on sterol regulatory element-binding protein-1a activation during adipogenic differentiation of 3T3-L1 cells. ongoing research,unassigned 2,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22634867&form=6&db=m 4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22949843&form=6&db=m Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23727646&form=6&db=m ?-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6. ongoing research,unassigned 4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24874946&form=6&db=m Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. ongoing research,unassigned 1,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25119660&form=6&db=m MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25231933&form=6&db=m Expression and roles of fatty acid synthase in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27264722&form=6&db=m Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells. unassigned - 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28118080&form=6&db=m Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28480406&form=6&db=m POSSIBLE REGULATION OF LDL-RECEPTOR BY NARINGENIN IN HEPG2 HEPATOMA CELL LINE. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28827398&form=6&db=m Network analyses identify liver-specific targets for treating liver diseases. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30824767&form=6&db=m Fenofibrate induces human hepatoma Hep3B cells apoptosis and necroptosis through inhibition of thioesterase domain of fatty acid synthase. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31021712&form=6&db=m Chrysin reduces the activity and protein level of mature forms of sterol regulatory element-binding proteins. ongoing research,unassigned 3,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31097694&form=6&db=m LXR? limits TGF?-dependent hepatocellular carcinoma associated fibroblast differentiation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31913745&form=6&db=m SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. ongoing research,unassigned 2,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921669&form=6&db=m Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32045588&form=6&db=m Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met. therapeutic application,unassigned 4,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32536483&form=6&db=m Inhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the ?-catenin/C-myc signaling pathway. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32694512&form=6&db=m Insulin signaling and glucose metabolism in different hepatoma cell lines deviate from hepatocyte physiology toward a convergent aberrant phenotype. ongoing research,unassigned 4,0 2.3.1.39 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15390078&form=6&db=m Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.39 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23928534&form=6&db=m [Expression of fatty acid synthase and its association with HER2 in invasive ductal carcinoma of breast]. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 2.3.1.39 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20701095&form=6&db=m Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12515624&form=6&db=m [Significance of fatty acid synthase expression in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.39 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15312350&form=6&db=m [Prognostic value of expression of FASE, HER-2/neu, bcl-2 and p53 in stage I non-small cell lung cancer] diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.39 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21044743&form=6&db=m Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22886728&form=6&db=m Metabolic Shifts Induced by Fatty Acid Synthase Inhibitor Orlistat in Non-small Cell Lung Carcinoma Cells Provide Novel Pharmacodynamic Biomarkers for Positron Emission Tomography and Magnetic Resonance Spectroscopy. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 2.3.1.39 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277534&form=6&db=m MicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase. unassigned - 2.3.1.39 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28443464&form=6&db=m Increased HAGLR expression promotes non-small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.3.1.39 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29449326&form=6&db=m Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.39 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31122252&form=6&db=m Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21442130&form=6&db=m Over Expression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and its Inhibition Potentiates Cisplatin Induced Apoptosis. causal interaction,unassigned 4,0 2.3.1.39 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112541&form=6&db=m Higher Level of Fatty Acid Synthase Enzyme Predicts Lower Rate of Completing Debulking Surgery in Epithelial Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.3.1.39 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18555493&form=6&db=m Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.39 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18639282&form=6&db=m Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027752&form=6&db=m Expression and prognostic significance of fatty acid synthase in clear cell renal cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.39 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33569391&form=6&db=m Fatty Acid Synthase Correlates With Prognosis-Related Abdominal Adipose Distribution and Metabolic Disorders of Clear Cell Renal Cell Carcinoma. diagnostic usage,ongoing research,unassigned 2,4,0 2.3.1.39 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11014573&form=6&db=m The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172638&form=6&db=m Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.3.1.39 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172643&form=6&db=m Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.39 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17334082&form=6&db=m [Analysis of gene expression of fatty acid synthase in squamous cell carcinoma of the oral cavity by the method of real-time quantitative PCR] diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17825601&form=6&db=m ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: correlation with clinical outcomes. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410580&form=6&db=m Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.39 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18528705&form=6&db=m Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.39 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18949744&form=6&db=m Immunohistochemical expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20604875&form=6&db=m ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22554590&form=6&db=m Inhibition of Fatty-acid Synthase Suppresses P-AKT and Induces Apoptosis in Bladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,3 2.3.1.39 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26718084&form=6&db=m Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho?AKT in bladder cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19399668&form=6&db=m A thought on the biological activities of black tea. causal interaction,unassigned 4,0 2.3.1.39 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22513183&form=6&db=m Dihydroquercetin: More than just an impurity? ongoing research,therapeutic application,unassigned 1,2,0 2.3.1.39 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889469&form=6&db=m Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan. therapeutic application,unassigned 1,0 2.3.1.39 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31202106&form=6&db=m Circulating serum fatty acid synthase is elevated in patients with diabetes and carotid artery stenosis and is LDL-associated. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31125161&form=6&db=m A fatty acid synthase gene (FASN3) from the integument tissue of Rhodnius prolixus contributes to cuticle water loss regulation. ongoing research,unassigned 3,0 2.3.1.39 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34421595&form=6&db=m Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression. therapeutic application,unassigned 1,0 2.3.1.39 Classical Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34132567&form=6&db=m Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B. causal interaction,unassigned 1,0 2.3.1.39 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24306512&form=6&db=m Fatty acid synthase inhibitor C75 ameliorates experimental colitis. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.3.1.39 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16439103&form=6&db=m Alterations in intestinal fatty acid metabolism in inflammatory bowel disease. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.39 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16753600&form=6&db=m Overexpression of fatty acid synthase in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3191475&form=6&db=m Changes in host liver fatty acid synthase in tumour-bearing mice. diagnostic usage,ongoing research,unassigned 2,1,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819582&form=6&db=m Inhibitor of fatty acid synthase induced apoptosis in human colonic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11866903&form=6&db=m [An experimental study on cerulenin induced apoptosis of human colonic cancer cells] ongoing research,unassigned 3,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955444&form=6&db=m Cohort study of fatty acid synthase expression and patient survival in colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723652&form=6&db=m Interaction of molecular markers and physical activity on mortality in patients with colon cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20491775&form=6&db=m Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22312135&form=6&db=m Body mass index and risk of colorectal cancer according to Fatty Acid synthase expression in the nurses' health study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23754252&form=6&db=m Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25173531&form=6&db=m Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. diagnostic usage,ongoing research,unassigned 2,1,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25451013&form=6&db=m Identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells. therapeutic application,unassigned 1,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28260110&form=6&db=m Inhibitory effect of emodin on fatty acid synthase, colon cancer proliferation and apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 2.3.1.39 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31788130&form=6&db=m A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells. diagnostic usage,ongoing research,unassigned 2,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350669&form=6&db=m Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17687193&form=6&db=m Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955444&form=6&db=m Cohort study of fatty acid synthase expression and patient survival in colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19358283&form=6&db=m Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19412426&form=6&db=m Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19491830&form=6&db=m High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20491775&form=6&db=m Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21437031&form=6&db=m Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells. ongoing research,unassigned 4,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21727995&form=6&db=m Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22218925&form=6&db=m The "HER2-PI3K/Akt-FASN Axis" Regulated Malignant Phenotype of Colorectal Cancer Cells. causal interaction,unassigned 1,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266115&form=6&db=m Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22312135&form=6&db=m Body mass index and risk of colorectal cancer according to Fatty Acid synthase expression in the nurses' health study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22722903&form=6&db=m The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22753716&form=6&db=m A significant role of lipogenic enzymes in colorectal cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22860766&form=6&db=m Fatty Acid Synthase Regulates Proliferation and Migration of Colorectal Cancer Cells Via HER2-PI3K/Akt Signaling Pathway. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23754252&form=6&db=m Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24430360&form=6&db=m Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: correlation with clinical outcomes. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24510238&form=6&db=m Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25970773&form=6&db=m Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26109148&form=6&db=m Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27139420&form=6&db=m Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway. causal interaction,unassigned 3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28938608&form=6&db=m Use of confocal laser endomicroscopy with a fluorescently labeled fatty acid to diagnose colorectal neoplasms. causal interaction,diagnostic usage,unassigned 1,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29681001&form=6&db=m Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872506&form=6&db=m Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30154249&form=6&db=m De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118685&form=6&db=m Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31262909&form=6&db=m In Vivo Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation. diagnostic usage,unassigned 2,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850342&form=6&db=m Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33604287&form=6&db=m LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer. diagnostic usage,unassigned 2,0 2.3.1.39 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34431463&form=6&db=m Targeting triglyceride metabolism for colorectal cancer prevention and therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0 2.3.1.39 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889469&form=6&db=m Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan. therapeutic application,unassigned 1,0 2.3.1.39 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889469&form=6&db=m Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan. therapeutic application,unassigned 1,0 2.3.1.39 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34452902&form=6&db=m Letter to the Editor: Morphoproteomics Confirms the Expression of Fatty Acid Synthase (FAS) in Reactive Alveolar Pneumocytes in a COVID-19 Victim: Biological and Therapeutic Implications. therapeutic application,unassigned 1,0 2.3.1.39 Cushing Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18782871&form=6&db=m Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 2.3.1.39 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31601151&form=6&db=m Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation. unassigned - 2.3.1.39 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8226759&form=6&db=m Construction, expression, and characterization of a mutated animal fatty acid synthase deficient in the dehydrase function. ongoing research,unassigned 1,0 2.3.1.39 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17240207&form=6&db=m Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.39 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26562505&form=6&db=m A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA. unassigned - 2.3.1.39 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20855599&form=6&db=m Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. causal interaction,unassigned 1,0 2.3.1.39 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22146564&form=6&db=m U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. ongoing research,unassigned 2,0 2.3.1.39 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22457619&form=6&db=m Dengue virus infection perturbs lipid homeostasis in infected mosquito cells. therapeutic application,unassigned 1,0 2.3.1.39 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24696471&form=6&db=m Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.3.1.39 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193229&form=6&db=m Involvement of fatty acid synthase in dengue virus infection. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889469&form=6&db=m Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan. therapeutic application,unassigned 1,0 2.3.1.39 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17492427&form=6&db=m Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.39 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19181734&form=6&db=m Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889469&form=6&db=m Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan. therapeutic application,unassigned 1,0 2.3.1.39 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21063365&form=6&db=m Electrophysiological changes, plasma vascular endothelial growth factor, fatty acid synthase, and adhesion molecules in diabetic neuropathy. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.39 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19216096&form=6&db=m Correlation of electroretinography b-wave absolute latency, plasma levels of human basic fibroblast growth factor, vascular endothelial growth factor, soluble fatty acid synthase, and adrenomedullin in diabetic retinopathy. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19531664&form=6&db=m A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays. causal interaction,unassigned 3,0 2.3.1.39 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20949026&form=6&db=m The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.39 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24964612&form=6&db=m [Effect of grain-bean package, grain-bean package dietary fiber and single whole grain dietary fiber on dyslipidemia rats]. ongoing research,unassigned 4,0 2.3.1.39 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33281537&form=6&db=m Green tea leaf powder prevents dyslipidemia in high-fat diet-fed mice by modulating gut microbiota. unassigned - 2.3.1.39 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055796&form=6&db=m Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice. causal interaction,unassigned 1,0 2.3.1.39 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30944506&form=6&db=m Immunohistochemical investigation of metabolic markers fatty acid synthase (FASN) and glucose transporter 1 (GLUT1) in normal endometrium, endometrial hyperplasia, and endometrial malignancy. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.39 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9690546&form=6&db=m Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.39 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751145&form=6&db=m Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15144342&form=6&db=m Fatty acid synthase expression and clinicopathological findings in endometrial cancer. causal interaction,unassigned 2,0 2.3.1.39 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809439&form=6&db=m Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators? causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 2.3.1.39 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23306391&form=6&db=m Fatty acid synthase is a potential therapeutic target in estrogen receptor-/progesterone receptor-positive endometrioid endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.39 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27188391&form=6&db=m Effects of Fatty Acid Synthase Inhibition by Orlistat on Proliferation of Endometrial Cancer Cell Lines. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.39 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577023&form=6&db=m Relevance of lipogenesis and AMPK/Akt/mTOR signaling pathway in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0 2.3.1.39 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18528464&form=6&db=m Theodore E. Woodward Award: Development of Novel, EBV-Targeted Therapies for EBV-Positive Tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.39 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20657182&form=6&db=m High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22723001&form=6&db=m Fatty acid synthase expression and esophageal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14988441&form=6&db=m Soy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18335269&form=6&db=m Molecular Mechanism of Age-Specific Hepatic Lipid Accumulation in PPARalpha (+/-):LDLR (+/-) Mice, an Obese Mouse Model. diagnostic usage,ongoing research,unassigned 2,3,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19728851&form=6&db=m Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis. diagnostic usage,ongoing research,unassigned 2,2,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19788606&form=6&db=m Roles of adipose restriction and metabolic factors in progression of steatosis to steatohepatitis in obese, diabetic mice. causal interaction,unassigned 2,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21555238&form=6&db=m Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22376231&form=6&db=m The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis. causal interaction,unassigned 2,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22648174&form=6&db=m Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet. ongoing research,unassigned 1,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24677715&form=6&db=m A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis. causal interaction,unassigned 1,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25028495&form=6&db=m Comparative proteomic study reveals 17?-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25766252&form=6&db=m Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers. therapeutic application,unassigned 1,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25925967&form=6&db=m [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26035386&form=6&db=m Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26892709&form=6&db=m De novo lipogenesis is suppressed during fasting but upregulated at population decline in cyclic voles. ongoing research,unassigned 3,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27695056&form=6&db=m The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys. ongoing research,therapeutic application,unassigned 1,3,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28103304&form=6&db=m Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys. ongoing research,therapeutic application,unassigned 1,3,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449683&form=6&db=m Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPK?/SREBP1 signaling pathway. ongoing research,unassigned 2,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539716&form=6&db=m Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29356583&form=6&db=m Comparison of Antiobesity Effects Between Gochujangs Produced Using Different Koji Products and Tabasco Hot Sauce in Rats Fed a High-Fat Diet. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29644441&form=6&db=m [11C]acetate PET as a tool for diagnosis of liver steatosis. diagnostic usage,unassigned 2,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786745&form=6&db=m Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non?alcoholic fatty liver disease. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30100495&form=6&db=m Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30415861&form=6&db=m Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very low density lipoprotein assembly. ongoing research,unassigned 1,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31178189&form=6&db=m Low abundance of mitofusin 2 in dairy cows with moderate fatty liver is associated with alterations in hepatic lipid metabolism. ongoing research,unassigned 1,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31233505&form=6&db=m Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894986&form=6&db=m Supplementation of Inulin with Various Degree of Polymerization Ameliorates Liver Injury and Gut Microbiota Dysbiosis in High Fat-Fed Obese Mice. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32230804&form=6&db=m Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33289350&form=6&db=m Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33715287&form=6&db=m Chronic everolimus treatment of high-fat diet mice leads to a reduction in obesity but impaired glucose tolerance. diagnostic usage,unassigned 3,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33839087&form=6&db=m Fatty acid synthase inhibition ameliorates diabetes induced liver injury in rodent experimental model. diagnostic usage,unassigned 3,0 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840666&form=6&db=m Effects of Dietary Supplementation with Myo-inositol on Hepatic Expression of Glycolytic and Fructolytic Enzyme Genes in Rats Fed a High-sucrose Diet. unassigned - 2.3.1.39 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33901636&form=6&db=m Ameliorative role of ellagic acid against acute liver steatosis in adult zebrafish experimental model. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.39 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18591393&form=6&db=m Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age. ongoing research,unassigned 3,0 2.3.1.39 Fibroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692057&form=6&db=m Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Fibromatosis, Gingival http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974853&form=6&db=m Proliferation of fibroblasts cultured from normal gingiva and hereditary gingival fibromatosis is dependent on fatty acid synthase activity. ongoing research,unassigned 4,0 2.3.1.39 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692057&form=6&db=m Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16583360&form=6&db=m Gastrointestinal stromal tumours overexpress fatty acid synthase. causal interaction,unassigned 3,0 2.3.1.39 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28442505&form=6&db=m Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.3.1.39 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21070743&form=6&db=m Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment. unassigned - 2.3.1.39 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21692239&form=6&db=m Electron microscopy morphology of the mitochondrial network in gliomas and their vascular microenvironment. unassigned - 2.3.1.39 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23416128&form=6&db=m Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.39 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24789255&form=6&db=m Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24984811&form=6&db=m Elevated expression of fatty acid synthase and nuclear localization of carnitine palmitoyltransferase 1C are common among human gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.3.1.39 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808816&form=6&db=m Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27601165&form=6&db=m Inhibition of fatty acid synthase suppresses neovascularization via regulating the expression of VEGF-A in glioma. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.39 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31936544&form=6&db=m Crocetin Extracted from Saffron Shows Antitumor Effects in Models of Human Glioblastoma. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32178271&form=6&db=m FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. causal interaction,unassigned 3,0 2.3.1.39 Granular Cell Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17227124&form=6&db=m Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors. causal interaction,unassigned 1,0 2.3.1.39 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21555238&form=6&db=m Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18782084&form=6&db=m Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha. therapeutic application,unassigned 1,0 2.3.1.39 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20126469&form=6&db=m A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. ongoing research,unassigned 3,0 2.3.1.39 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20196803&form=6&db=m Expression of genes involved in lipogenesis is not increased in patients with HCV genotype 3 in human liver. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17188392&form=6&db=m Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. therapeutic application,unassigned 1,0 2.3.1.39 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18420801&form=6&db=m Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2. causal interaction,unassigned 1,0 2.3.1.39 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18830996&form=6&db=m Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production. causal interaction,unassigned 4,0 2.3.1.39 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23427160&form=6&db=m Hepatitis C virus replication is modulated by the interaction of non-structural protein NS5B and fatty acid synthase. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0 2.3.1.39 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23601646&form=6&db=m Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.39 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8605019&form=6&db=m Regulation of fatty acid synthase expression by cholesterol in human cultured cells. ongoing research,unassigned 4,0 2.3.1.39 Hepatoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34134963&form=6&db=m [Effect of fatty acid synthase gene silencing on lipid metabolism and biological behaviors of human hepatoblastoma HepG2 cells]. ongoing research,unassigned 4,0 2.3.1.39 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25913854&form=6&db=m Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.39 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20356977&form=6&db=m Hyperglycemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.3.1.39 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088862&form=6&db=m Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia. causal interaction,unassigned 2,0 2.3.1.39 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31353547&form=6&db=m Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. causal interaction,unassigned 1,0 2.3.1.39 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33226385&form=6&db=m Ultrasonic-microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice. ongoing research,unassigned 2,0 2.3.1.39 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=229050&form=6&db=m Chronic hyperinsulinemia in the fetal rhesus monkey: effects on hepatic enzymes active in lipogenesis and carbohydrate metabolism. causal interaction,unassigned 1,0 2.3.1.39 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6385723&form=6&db=m Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes. diagnostic usage,unassigned 1,0 2.3.1.39 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7869920&form=6&db=m In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues. ongoing research,unassigned 4,0 2.3.1.39 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26927042&form=6&db=m Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.39 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30664851&form=6&db=m Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis. unassigned - 2.3.1.39 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31022865&form=6&db=m Dietary Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) Operate by Different Mechanisms to Modulate Hepatic Steatosis and Hyperinsulemia in fa/fa Zucker Rats. unassigned - 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9575816&form=6&db=m Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein. ongoing research,unassigned 4,0 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127373&form=6&db=m Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet. therapeutic application,unassigned 1,0 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23832364&form=6&db=m Pu-erh tea suppresses diet-induced body fat accumulation in C57BL/6J mice by down-regulating SREBP-1c and related molecules. unassigned - 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25055996&form=6&db=m Aqueous extract of post-fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition. ongoing research,unassigned 1,0 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26305715&form=6&db=m Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. causal interaction,unassigned 1,0 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26321743&form=6&db=m The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin--A biochemical study in rats subjected to experimental hyperlipidemia and obesity. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29383887&form=6&db=m [Effect of Eletroacupuncture Intervention on Insulin Resistance, Lipid Metabolic Disorder and Expression of Hepatic SREBP-1 c and Fatty Acid Synthase Proteins in Rats with Hyperlipidemia]. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30935037&form=6&db=m Melatonin Improves Fatty Liver Syndrome by Inhibiting the Lipogenesis Pathway in Hamsters with High-Fat Diet-Induced Hyperlipidemia. causal interaction,unassigned 3,0 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32074961&form=6&db=m Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease. causal interaction,unassigned 2,0 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33226385&form=6&db=m Ultrasonic-microwave assisted extraction of total triterpenoid acids from Corni Fructus and hypoglycemic and hypolipidemic activities of the extract in mice. ongoing research,unassigned 2,0 2.3.1.39 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300795&form=6&db=m Pediococcus pentosaceus PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice. unassigned - 2.3.1.39 Hyperparathyroidism, Secondary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556475&form=6&db=m Immunohistochemical study of fatty acid synthase, Ki67, proliferating cell nuclear antigen, and p53 expression in hyperplastic parathyroids. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7772036&form=6&db=m DNase I hypersensitivity sites and nuclear protein binding on the fatty acid synthase gene: identification of an element with properties similar to known glucose-responsive elements. ongoing research,unassigned 1,0 2.3.1.39 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11110846&form=6&db=m Copper deficiency induces hepatic fatty acid synthase gene transcription in rats by increasing the nuclear content of mature sterol regulatory element binding protein 1. unassigned - 2.3.1.39 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22448300&form=6&db=m The inhibitory effect of cerulenin to yeasts is fungicidal. therapeutic application,unassigned 1,0 2.3.1.39 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19878707&form=6&db=m Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. therapeutic application,unassigned 1,0 2.3.1.39 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34457121&form=6&db=m The Emerging Role of Fatty Acid Synthase in Hypoxia-Induced Pulmonary Hypertensive Mouse Energy Metabolism. causal interaction,unassigned 1,0 2.3.1.39 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27061087&form=6&db=m Inhibition of fatty acid synthase is protective in pulmonary hypertension. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.39 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31465767&form=6&db=m Involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9687545&form=6&db=m Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 2.3.1.39 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12489075&form=6&db=m Upregulation of fatty acid synthase gene expression in experimental chronic renal failure. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.39 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18395093&form=6&db=m Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. ongoing research,unassigned 2,0 2.3.1.39 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23994635&form=6&db=m Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats. ongoing research,unassigned 2,0 2.3.1.39 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24062609&form=6&db=m Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits. diagnostic usage,ongoing research,unassigned 4,1,0 2.3.1.39 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3041965&form=6&db=m A tissue-specific increase in lipogenesis in rat brown adipose tissue in hypothyroidism. ongoing research,unassigned 1,0 2.3.1.39 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30272292&form=6&db=m A family with hypothyroidism caused by fatty acid synthase and apolipoprotein B receptor mutations. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8250834&form=6&db=m Construction of a cDNA encoding the multifunctional animal fatty acid synthase and expression in Spodoptera frugiperda cells using baculoviral vectors. ongoing research,unassigned 2,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8828218&form=6&db=m Requirement for the Candida albicans FAS2 gene for infection in a rat model of oropharyngeal candidiasis. ongoing research,unassigned 2,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20027295&form=6&db=m Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection. ongoing research,unassigned 2,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20707918&form=6&db=m Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21949814&form=6&db=m West Nile virus replication requires fatty acid synthesis but is independent on phosphatidylinositol-4-phosphate lipids. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23601646&form=6&db=m Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23746808&form=6&db=m Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex. causal interaction,unassigned 2,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24478438&form=6&db=m Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24979181&form=6&db=m Adenovirus type 9 enhances differentiation and decreases cytokine release from preadipocytes. causal interaction,unassigned 4,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25047997&form=6&db=m Total synthesis of (-)-platensimycin by advancing oxocarbenium- and iminium-mediated catalytic methods. therapeutic application,unassigned 4,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145135&form=6&db=m Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands. unassigned - 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27903451&form=6&db=m Fatty acid synthase plays a positive role in shrimp immune responses against Vibrio parahaemolyticus infection. therapeutic application,unassigned 1,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193229&form=6&db=m Involvement of fatty acid synthase in dengue virus infection. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28883690&form=6&db=m Direct-acting antiviral agents against hepatitis C virus and lipid metabolism. ongoing research,unassigned 2,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28962653&form=6&db=m Cellular fatty acid synthase is required for late stages of HIV-1 replication. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30118512&form=6&db=m Stearoly-CoA desaturase 1 differentiates early and advanced dengue virus infections and determines virus particle infectivity. unassigned - 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31875021&form=6&db=m Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus. diagnostic usage,ongoing research,unassigned 3,1,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388899&form=6&db=m Metabolic profiles of fish nodavirus infection in vitro: RGNNV induced and exploited cellular fatty acid synthesis for virus infection. causal interaction,unassigned 3,0 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32777979&form=6&db=m Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection. unassigned - 2.3.1.39 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32849631&form=6&db=m Palmitic Acid Promotes Virus Replication in Fish Cell by Modulating Autophagy Flux and TBK1-IRF3/7 Pathway. diagnostic usage,unassigned 3,0 2.3.1.39 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24306512&form=6&db=m Fatty acid synthase inhibitor C75 ameliorates experimental colitis. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2690821&form=6&db=m Development of insulin sensitivity in white adipose tissue during the suckling-weaning transition in the rat. Involvement of glucose transport and lipogenesis. causal interaction,unassigned 4,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9687545&form=6&db=m Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16041833&form=6&db=m The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16638824&form=6&db=m Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1. causal interaction,unassigned 3,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16729974&form=6&db=m Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice. causal interaction,unassigned 4,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17241878&form=6&db=m Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. ongoing research,unassigned 2,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17272392&form=6&db=m Prenatal and postnatal pathways to obesity: different underlying mechanisms, different metabolic outcomes. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369525&form=6&db=m Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis. therapeutic application,unassigned 1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18483661&form=6&db=m [Molecular targets for new drug discovery to treat type 2 diabetes and obesity] causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19181734&form=6&db=m Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19733654&form=6&db=m Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion. diagnostic usage,ongoing research,unassigned 2,2,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20299470&form=6&db=m Extracellular Fatty Acid Synthase: a possible surrogate biomarker of insulin resistance. ongoing research,unassigned 3,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22032375&form=6&db=m Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-? and leptin, and adipose tissue gene expression. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376793&form=6&db=m Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24677715&form=6&db=m A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis. causal interaction,unassigned 1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24811405&form=6&db=m Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice. causal interaction,diagnostic usage,unassigned 1,1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871498&form=6&db=m A combination of probiotics and whey proteins enhances anti-obesity effects of calcium and dairy products during nutritional energy restriction in aP2-agouti transgenic mice. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26161966&form=6&db=m Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production. unassigned - 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26927042&form=6&db=m Solanum nigrum Protects against Hepatic Fibrosis via Suppression of Hyperglycemia in High-Fat/Ethanol Diet-Induced Rats. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27695056&form=6&db=m The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys. ongoing research,therapeutic application,unassigned 1,3,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27777319&form=6&db=m Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis. ongoing research,unassigned 3,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28103304&form=6&db=m Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys. ongoing research,therapeutic application,unassigned 1,3,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29075849&form=6&db=m Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet. unassigned - 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088862&form=6&db=m Regulation of malonyl-CoA-acyl carrier protein transacylase network in umbilical cord blood affected by intrauterine hyperglycemia. causal interaction,unassigned 2,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29383887&form=6&db=m [Effect of Eletroacupuncture Intervention on Insulin Resistance, Lipid Metabolic Disorder and Expression of Hepatic SREBP-1 c and Fatty Acid Synthase Proteins in Rats with Hyperlipidemia]. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29575055&form=6&db=m MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease. ongoing research,unassigned 2,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381838&form=6&db=m SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30664851&form=6&db=m Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis. unassigned - 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32255390&form=6&db=m The 1975 type Japanese diet improves the gut microbial flora and inhibits visceral fat accumulation in mice. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.39 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616223&form=6&db=m The gene expression of long non-coding RNAs (lncRNAs): MEG3 and H19 in adipose tissues from obese women and its association with insulin resistance and obesity indices. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.3.1.39 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357280&form=6&db=m Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32386572&form=6&db=m FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits. ongoing research,unassigned 4,0 2.3.1.39 Ketosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30594378&form=6&db=m High expression of cell death-inducing DFFA-like effector a (CIDEA) promotes milk fat content in dairy cows with clinical ketosis. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12489075&form=6&db=m Upregulation of fatty acid synthase gene expression in experimental chronic renal failure. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.39 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18555493&form=6&db=m Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.39 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18639282&form=6&db=m Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28654693&form=6&db=m Fatty acid synthase reprograms the epigenome in uterine leiomyosarcomas. causal interaction,ongoing research,unassigned 2,2,0 2.3.1.39 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631008&form=6&db=m Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.39 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11876988&form=6&db=m [Proliferation inhibition and apoptosis induction of K562 cells by fatty acid synthase inhibitor--cerulenin] diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26967395&form=6&db=m Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway. ongoing research,unassigned 4,0 2.3.1.39 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775585&form=6&db=m Fatty acid synthase inhibitor orlistat impairs cell growth and down-regulates PD-L1 expression of a human T-cell leukemia line. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Lipid Metabolism Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32530448&form=6&db=m The ameliorative effect of Lactobacillus plantarum Y44 oral administration on inflammation and lipid metabolism in obese mice fed with a high fat diet. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.3.1.39 Liposarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18259941&form=6&db=m The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. ongoing research,unassigned 3,0 2.3.1.39 Liposarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116881&form=6&db=m Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20606731&form=6&db=m Expression of fatty acid synthase in nonalcoholic fatty liver disease. ongoing research,unassigned 2,0 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22513183&form=6&db=m Dihydroquercetin: More than just an impurity? ongoing research,therapeutic application,unassigned 1,2,0 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539716&form=6&db=m Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell. unassigned - 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28827398&form=6&db=m Network analyses identify liver-specific targets for treating liver diseases. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786745&form=6&db=m Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non?alcoholic fatty liver disease. unassigned - 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580553&form=6&db=m n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. ongoing research,unassigned 1,0 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31110049&form=6&db=m FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31913745&form=6&db=m SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. ongoing research,unassigned 2,0 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007939&form=6&db=m Erratum: FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice. ongoing research,unassigned 2,0 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33190588&form=6&db=m TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. ongoing research,unassigned 1,0 2.3.1.39 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33289350&form=6&db=m Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.39 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580553&form=6&db=m n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. ongoing research,unassigned 1,0 2.3.1.39 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23821378&form=6&db=m Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase. causal interaction,unassigned 3,0 2.3.1.39 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31076001&form=6&db=m Aberrant lipid metabolism as a therapeutic target in liver cancer. unassigned - 2.3.1.39 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31921669&form=6&db=m Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.39 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32699531&form=6&db=m Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.3.1.39 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34046694&form=6&db=m Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12515624&form=6&db=m [Significance of fatty acid synthase expression in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15312350&form=6&db=m [Prognostic value of expression of FASE, HER-2/neu, bcl-2 and p53 in stage I non-small cell lung cancer] diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404812&form=6&db=m FDG-PET for pharmacodynamic assessment of the fatty acid synthase inhibitor C75 in an experimental model of lung cancer. ongoing research,therapeutic application,unassigned 2,4,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18056164&form=6&db=m Selective inhibition of fatty acid synthase for lung cancer treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413838&form=6&db=m Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21044743&form=6&db=m Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21182810&form=6&db=m [Clinical significance and expression of fatty acid synthase mRNA in lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22769244&form=6&db=m Different fatty acid metabolism effects of (¿)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277534&form=6&db=m MicroRNA-320 was downregulated in non-small cell lung cancer and inhibited cell proliferation, migration and invasion by targeting fatty acid synthase. unassigned - 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28443464&form=6&db=m Increased HAGLR expression promotes non-small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29449326&form=6&db=m Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31122252&form=6&db=m Inhibition of FASN suppresses the malignant biological behavior of non-small cell lung cancer cells via deregulating glucose metabolism and AKT/ERK pathway. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33729695&form=6&db=m Fast Nanoliter-Scale Cell Assays Using Droplet Microarray-Mass Spectrometry Imaging. therapeutic application,unassigned 3,0 2.3.1.39 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18639282&form=6&db=m Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18770866&form=6&db=m Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.3.1.39 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884752&form=6&db=m Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer. diagnostic usage,unassigned 3,0 2.3.1.39 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22485149&form=6&db=m Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22877747&form=6&db=m Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.39 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24060750&form=6&db=m Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.3.1.39 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885322&form=6&db=m The double dealing of cyclin D1. therapeutic application,unassigned 1,0 2.3.1.39 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32810718&form=6&db=m Function and regulation of lipid signaling in lymphomagenesis: A novel target in cancer research and therapy. unassigned - 2.3.1.39 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33664809&form=6&db=m Upregulation of fatty acid synthase in MYC and BCL-2 double-expressor lymphoma. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.39 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20423996&form=6&db=m Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.39 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25937841&form=6&db=m FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.39 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26322888&form=6&db=m Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. unassigned - 2.3.1.39 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26829127&form=6&db=m Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure. unassigned - 2.3.1.39 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32249639&form=6&db=m Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.39 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33471067&form=6&db=m Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBP?/SREBP-1 pathway. therapeutic application,unassigned 1,0 2.3.1.39 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20423996&form=6&db=m Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.39 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25937841&form=6&db=m FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.39 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32249639&form=6&db=m Fatty acid synthase and adenosine monophosphate-activated protein kinase regulate cell survival and drug sensitivity in diffuse large B-cell lymphoma. ongoing research,therapeutic application,unassigned 3,3,0 2.3.1.39 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22485149&form=6&db=m Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885322&form=6&db=m The double dealing of cyclin D1. therapeutic application,unassigned 1,0 2.3.1.39 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22877747&form=6&db=m Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.39 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24060750&form=6&db=m Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.3.1.39 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21060311&form=6&db=m Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12534800&form=6&db=m Fatty acid synthase expression in melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15467715&form=6&db=m Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis. causal interaction,unassigned 3,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15920554&form=6&db=m Fatty acid synthase expression in cutaneous melanocytic neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17904792&form=6&db=m Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18770866&form=6&db=m Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20805790&form=6&db=m Inhibition of fatty acid synthase in melanoma cells activates the intrinsic pathway of apoptosis. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21213365&form=6&db=m Visualizing inhibition of fatty acid synthase through mass spectrometric analysis of mitochondria from melanoma cells. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21819495&form=6&db=m Expression of fatty acid synthase (FASN) in oral nevi and melanoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22425483&form=6&db=m Primary nasal mucosal melanoma in Brazil: clinicopathologic and immunohistochemical study of 12 patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22892389&form=6&db=m The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25499031&form=6&db=m Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokines. causal interaction,diagnostic usage,unassigned 1,3,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25545058&form=6&db=m Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27918556&form=6&db=m Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28654463&form=6&db=m Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi. therapeutic application,unassigned 1,0 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30862716&form=6&db=m Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4 2.3.1.39 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31863126&form=6&db=m The antimetastatic activity of orlistat is accompanied by an antitumoral immune response in mouse melanoma. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20511185&form=6&db=m Fatty acid synthase as a novel target for meningioma therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22744755&form=6&db=m Fatty acid synthase is a predictive marker for aggressiveness in meningiomas. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.3.1.39 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23064941&form=6&db=m Usefulness of immunohistochemical expression analysis of metabolic-related molecules to differentiate between intracranial neoplastic and non-neoplastic lesions. causal interaction,unassigned 4,0 2.3.1.39 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31927122&form=6&db=m MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.39 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11205903&form=6&db=m Increased fatty acid synthase is a therapeutic target in mesothelioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 2.3.1.39 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19181734&form=6&db=m Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29701265&form=6&db=m Cyclopropaneoctanoic Acid 2-Hexyl Upregulates the Expression of Genes Responsible for Lipid Synthesis and Release in Human Hepatic HepG2 Cells. unassigned - 2.3.1.39 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32810718&form=6&db=m Function and regulation of lipid signaling in lymphomagenesis: A novel target in cancer research and therapy. unassigned - 2.3.1.39 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549805&form=6&db=m Increased activity of the oncogenic fatty acid synthase and the impaired glucose uptake in the metabolic syndrome. unassigned - 2.3.1.39 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145135&form=6&db=m Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands. unassigned - 2.3.1.39 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889469&form=6&db=m Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan. therapeutic application,unassigned 1,0 2.3.1.39 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17343199&form=6&db=m [Study on proliferation inhibiting and apoptosis inducing effects of cerulenin on multiple myeloma cells] diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410446&form=6&db=m Fatty acid synthase is a novel therapeutic target in multiple myeloma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18543396&form=6&db=m Increased fatty acid synthase as a potential therapeutic target in multiple myeloma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4 2.3.1.39 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712068&form=6&db=m Retraction. Fatty acid synthase is a novel therapeutic target in multiple myeloma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25192858&form=6&db=m Erythrocyte membrane fatty acids in multiple myeloma patients. therapeutic application,unassigned 4,0 2.3.1.39 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22448300&form=6&db=m The inhibitory effect of cerulenin to yeasts is fungicidal. therapeutic application,unassigned 1,0 2.3.1.39 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23208675&form=6&db=m Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.3.1.39 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32944403&form=6&db=m Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.39 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34546840&form=6&db=m Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase. causal interaction,unassigned 1,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17146477&form=6&db=m Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays. diagnostic usage,ongoing research,unassigned 3,1,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18639282&form=6&db=m Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18770866&form=6&db=m Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18814184&form=6&db=m The tyrosine kinase receptor HER2 (erbB-2): from oncogenesis to adipogenesis. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20491775&form=6&db=m Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266115&form=6&db=m Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22723001&form=6&db=m Fatty acid synthase expression and esophageal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22771636&form=6&db=m Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22892389&form=6&db=m The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162615&form=6&db=m Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370361&form=6&db=m Anticancer activity of pristimerin in epidermal growth factor receptor 2-positive SKBR3 human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24362464&form=6&db=m The Fatty Acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24510238&form=6&db=m Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25017943&form=6&db=m Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25451013&form=6&db=m Identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells. therapeutic application,unassigned 1,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26217691&form=6&db=m Data supporting the identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells. diagnostic usage,therapeutic application,unassigned 1,2,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27139420&form=6&db=m Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway. causal interaction,unassigned 3,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713913&form=6&db=m The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884752&form=6&db=m Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer. diagnostic usage,unassigned 3,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321577&form=6&db=m 8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90? downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells. therapeutic application,unassigned 1,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928446&form=6&db=m Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118685&form=6&db=m Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31300609&form=6&db=m An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677030&form=6&db=m SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32699531&form=6&db=m Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.3.1.39 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33240433&form=6&db=m Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3191475&form=6&db=m Changes in host liver fatty acid synthase in tumour-bearing mice. diagnostic usage,ongoing research,unassigned 2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6130760&form=6&db=m Studies on acetyl-CoA carboxylase and fatty acid synthase from rat mammary gland and mammary tumours. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8022791&form=6&db=m Fatty acid synthesis: a potential selective target for antineoplastic therapy. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8422428&form=6&db=m Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630954&form=6&db=m Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631008&form=6&db=m Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8640795&form=6&db=m Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8816886&form=6&db=m Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9006336&form=6&db=m Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9067276&form=6&db=m Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9191002&form=6&db=m Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492058&form=6&db=m Tumor necrosis factor-alpha causes insulin receptor substrate-2-mediated insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipocytes. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9575816&form=6&db=m Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein. ongoing research,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593836&form=6&db=m Characterization of fatty acid synthase in cell lines derived from experimental mammary tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9699873&form=6&db=m Androgens and the control of lipid metabolism in human prostate cancer cells. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9788612&form=6&db=m Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10228495&form=6&db=m Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10694501&form=6&db=m Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10716717&form=6&db=m Synthesis and antitumor activity of an inhibitor of fatty acid synthase. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10737707&form=6&db=m Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11014573&form=6&db=m The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032949&form=6&db=m Immunohistochemical study of fatty acid synthase in ovarian neoplasms. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11064454&form=6&db=m Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway. therapeutic application,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11082286&form=6&db=m Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia. ongoing research,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11176534&form=6&db=m Fatty acid synthase: an early molecular marker of progression of prostatic adenocarcinoma to androgen independence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11205903&form=6&db=m Increased fatty acid synthase is a therapeutic target in mesothelioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245456&form=6&db=m Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11323104&form=6&db=m Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830512&form=6&db=m Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11866903&form=6&db=m [An experimental study on cerulenin induced apoptosis of human colonic cancer cells] ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11866947&form=6&db=m [Cerulenin inhibits growth of human colonic carcinoma in nude mice] ongoing research,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12213216&form=6&db=m Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12324706&form=6&db=m Overexpression of fatty acid synthase in oesophageal squamous cell dysplasia and carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12517789&form=6&db=m Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis. diagnostic usage,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12518220&form=6&db=m [Fatty acid synthase: specific target for cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12531252&form=6&db=m Inhibitive effect of zinc ion on fatty acid synthase from chicken liver. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12652618&form=6&db=m Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12680233&form=6&db=m Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750860&form=6&db=m Large-scale analysis of HLA peptides presented by HLA-Cw4. diagnostic usage,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12766036&form=6&db=m Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12820377&form=6&db=m Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839976&form=6&db=m RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12918062&form=6&db=m Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12925533&form=6&db=m Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939396&form=6&db=m Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605988&form=6&db=m Increased activity of glycerol 3-phosphate dehydrogenase and other lipogenic enzymes in human bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14612531&form=6&db=m Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. ongoing research,therapeutic application,unassigned 4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14689581&form=6&db=m Fatty acid synthase: a metabolic oncogene in prostate cancer? ongoing research,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767544&form=6&db=m Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026345&form=6&db=m Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15050917&form=6&db=m The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15094777&form=6&db=m Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138278&form=6&db=m A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. causal interaction,therapeutic application,unassigned 2,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15144342&form=6&db=m Fatty acid synthase expression and clinicopathological findings in endometrial cancer. causal interaction,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15235125&form=6&db=m Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15390078&form=6&db=m Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15467715&form=6&db=m Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15489885&form=6&db=m Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15500005&form=6&db=m Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15507492&form=6&db=m Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523670&form=6&db=m In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells. causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15533929&form=6&db=m Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15543204&form=6&db=m Overexpression of fatty acid synthase in chemically and hormonally induced hepatocarcinogenesis of the rat. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15607569&form=6&db=m Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids? causal interaction,ongoing research,unassigned 1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15669079&form=6&db=m Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15694180&form=6&db=m Obesity, fatty acid synthase, and cancer: serendipity or forgotten causal linkage? unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870863&form=6&db=m The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880754&form=6&db=m High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15897909&form=6&db=m FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15920554&form=6&db=m Fatty acid synthase expression in cutaneous melanocytic neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16061653&form=6&db=m RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. ongoing research,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16084671&form=6&db=m Increased ratio of saturated to unsaturated C18 fatty acids in colonic adenocarcinoma: implications for cryotherapy and lipid raft function. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16154299&form=6&db=m Adaptive evolution of the human fatty acid synthase gene: support for the cancer selection and fat utilization hypotheses? ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247515&form=6&db=m Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer. ongoing research,therapeutic application,unassigned 2,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16300755&form=6&db=m S14 protein in breast cancer cells: direct evidence of regulation by SREBP-1c, superinduction with progestin, and effects on cell growth. therapeutic application,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16374067&form=6&db=m Expression of liver-type fatty-acid-binding protein, fatty acid synthase and vascular endothelial growth factor in human lung carcinoma. ongoing research,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16413534&form=6&db=m Mallory body forming cells express the preneoplastic hepatocyte phenotype. diagnostic usage,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16546963&form=6&db=m Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552628&form=6&db=m Expression of "Spot 14" (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker. diagnostic usage,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16564913&form=6&db=m Fatty acid synthase gene overexpression and copy number gain in prostate adenocarcinoma. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16583360&form=6&db=m Gastrointestinal stromal tumours overexpress fatty acid synthase. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16611078&form=6&db=m Inhibition of fatty acid synthase by polyphenols. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707454&form=6&db=m Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740734&form=6&db=m Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778164&form=6&db=m Fatty acid synthase and cancer: new application of an old pathway. therapeutic application,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778562&form=6&db=m Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778563&form=6&db=m Increased lipogenesis in cancer cells: new players, novel targets. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16798056&form=6&db=m Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16870425&form=6&db=m Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16905103&form=6&db=m Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951176&form=6&db=m The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16962997&form=6&db=m Cerulenin-mediated apoptosis is involved in adenine metabolic pathway. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16969344&form=6&db=m Fatty acid synthase: a novel target for antiglioma therapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17064684&form=6&db=m Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma. diagnostic usage,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17168665&form=6&db=m Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? causal interaction,diagnostic usage,unassigned 1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17168666&form=6&db=m Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9). ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17227124&form=6&db=m Phosphorylated histone H3, Ki-67, p21, fatty acid synthase, and cleaved caspase-3 expression in benign and atypical granular cell tumors. causal interaction,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17283163&form=6&db=m Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350669&form=6&db=m Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17352212&form=6&db=m MRNA stability and overexpression of fatty acid synthase in human breast cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17565694&form=6&db=m Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17618296&form=6&db=m Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17620441&form=6&db=m Novel antagonists of the thioesterase domain of human fatty acid synthase. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653900&form=6&db=m A new targeting approach for breast cancer gene therapy using the human fatty acid synthase promoter. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17687193&form=6&db=m Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786030&form=6&db=m Caveolin-1 is Required for the Upregulation of Fatty Acid Synthase (FASN), a Tumor Promoter, During Prostate Cancer Progression. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17847090&form=6&db=m Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands. therapeutic application,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17847719&form=6&db=m Evaluation of the inhibitory activities of aceraceous plants on fatty acid synthase. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17882277&form=6&db=m Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18056164&form=6&db=m Selective inhibition of fatty acid synthase for lung cancer treatment. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18192687&form=6&db=m Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199615&form=6&db=m 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18253084&form=6&db=m Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation? causal interaction,ongoing research,unassigned 2,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281474&form=6&db=m Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18304378&form=6&db=m Sugar and fat - that's where it's at: metabolic changes in tumors. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18369337&form=6&db=m Long-term effects of maternal magnesium restriction on adiposity and insulin resistance in rat pups. diagnostic usage,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18372237&form=6&db=m Adipose tissue loss in adjuvant arthritis is associated with a decrease in lipogenesis, but not with an increase in lipolysis. diagnostic usage,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18380011&form=6&db=m The novel inhibitory effect of Pangdahai on fatty acid synthase. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410275&form=6&db=m A case of metaplastic meningioma with extensive xanthomatous change. causal interaction,diagnostic usage,unassigned 1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18410580&form=6&db=m Fatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findings. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18411195&form=6&db=m An easy, rapid and objective mathematical method to identify fatty acid synthase (oncogenic antigen-519) modulators with potential anticancer value. causal interaction,therapeutic application,unassigned 2,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413838&form=6&db=m Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18452391&form=6&db=m A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production. therapeutic application,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18523653&form=6&db=m Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18528464&form=6&db=m Theodore E. Woodward Award: Development of Novel, EBV-Targeted Therapies for EBV-Positive Tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18555493&form=6&db=m Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18639282&form=6&db=m Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18671164&form=6&db=m Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells. therapeutic application,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18710210&form=6&db=m Synthesis of novel beta-lactone inhibitors of fatty acid synthase. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18723500&form=6&db=m Fatty acid synthase inhibition results in a magnetic resonance-detectable drop in phosphocholine. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18751912&form=6&db=m Fatty Acid Synthase Activity in Tumor Cells. causal interaction,ongoing research,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18802406&form=6&db=m Co-expression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18813848&form=6&db=m Analyzing effects of extra-virgin olive oil polyphenols on breast cancer-associated fatty acid synthase protein expression using reverse-phase protein microarrays. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18814184&form=6&db=m The tyrosine kinase receptor HER2 (erbB-2): from oncogenesis to adipogenesis. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18817351&form=6&db=m [Fatty acid synthase and prostate cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18820672&form=6&db=m Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18838960&form=6&db=m Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19032940&form=6&db=m AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074856&form=6&db=m Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19139131&form=6&db=m Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173288&form=6&db=m Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19181734&form=6&db=m Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19189648&form=6&db=m Green tea catechin inhibits fatty acid synthase without stimulating carnitine palmitoyltransferase-1 or inducing weight loss in experimental animals. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239908&form=6&db=m Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19358283&form=6&db=m Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer prevention. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19381703&form=6&db=m Inhibition of Fatty Acid Synthase by Orlistat Accelerates Gastric Tumor Cell Apoptosis in Culture and Increases Survival Rates in Gastric Tumor Bearing Mice In Vivo. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19412426&form=6&db=m Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430421&form=6&db=m SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19491830&form=6&db=m High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19505918&form=6&db=m A cohort study of p27 localization in colon cancer, body mass index, and patient survival. diagnostic usage,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19517019&form=6&db=m p63 promotes cell survival through fatty acid synthase. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19531664&form=6&db=m A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19543323&form=6&db=m Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19621387&form=6&db=m Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19639174&form=6&db=m Differential gene expression in tumor adjacent histologically normal prostatic tissue indicates field cancerization. diagnostic usage,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19686742&form=6&db=m A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers. diagnostic usage,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723916&form=6&db=m Serum fatty acid synthase as a marker of pancreatic neoplasia. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19878771&form=6&db=m Chapter 3: The shifting balance between CLU forms during tumor progression. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20041784&form=6&db=m Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043266&form=6&db=m The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20067991&form=6&db=m The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element-binding protein-1 activation in cancer cells. ongoing research,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20126469&form=6&db=m A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20148945&form=6&db=m Peptides from purified soybean beta-conglycinin inhibit fatty acid synthase by interaction with the thioesterase catalytic domain. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20218616&form=6&db=m Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20228137&form=6&db=m Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20356977&form=6&db=m Hyperglycemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20360933&form=6&db=m Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20373869&form=6&db=m Fatty acid synthase as a potential therapeutic target in cancer. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20423996&form=6&db=m Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B-Cell Lymphoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20440768&form=6&db=m Global gene expression profiles of ischemic preconditioning in deceased donor liver transplantation. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20491775&form=6&db=m Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20511185&form=6&db=m Fatty acid synthase as a novel target for meningioma therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530413&form=6&db=m Gene expression analysis by cDNA microarray in oral cancers from two Western populations. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20544979&form=6&db=m Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20577697&form=6&db=m Click-based synthesis and proteomic profiling of lipstatin analogues. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20595235&form=6&db=m Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. causal interaction,ongoing research,unassigned 2,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20604875&form=6&db=m ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20657182&form=6&db=m High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20679621&form=6&db=m Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20713491&form=6&db=m HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20817450&form=6&db=m Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20890301&form=6&db=m Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and medulloblastoma. diagnostic usage,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20953243&form=6&db=m The pathogenesis of prostate cancer: from molecular to metabolic alterations. diagnostic usage,ongoing research,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20965718&form=6&db=m Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20967760&form=6&db=m Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21041072&form=6&db=m Expression and vitamin D(3) regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21044743&form=6&db=m Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21111730&form=6&db=m Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21170507&form=6&db=m Thiazolidinediones/PPAR? agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21182810&form=6&db=m [Clinical significance and expression of fatty acid synthase mRNA in lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21188630&form=6&db=m Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21385214&form=6&db=m Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21442130&form=6&db=m Over Expression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and its Inhibition Potentiates Cisplatin Induced Apoptosis. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21565896&form=6&db=m Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21605850&form=6&db=m Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21727995&form=6&db=m Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21752639&form=6&db=m Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21762084&form=6&db=m Mouse Prostate Proteome Changes Induced by Oral Pentagalloylglucose Treatment Suggest Targets for Cancer Chemoprevention. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21768098&form=6&db=m NF-{kappa}B mediates a protective response in cancer cells treated with inhibitors of fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21922386&form=6&db=m Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22032375&form=6&db=m Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-? and leptin, and adipose tissue gene expression. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22052253&form=6&db=m Enhanced antitumor activity of epirubicin combined with cerulenin in osteosarcoma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127986&form=6&db=m Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22135723&form=6&db=m Immunohistochemical expressions of fatty acid synthase and phosphorylated c-Met in thyroid carcinomas of follicular origin. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207896&form=6&db=m Role of sp transcription factors in the regulation of cancer cell metabolism. causal interaction,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22218925&form=6&db=m The "HER2-PI3K/Akt-FASN Axis" Regulated Malignant Phenotype of Colorectal Cancer Cells. causal interaction,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266115&form=6&db=m Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22312133&form=6&db=m Associations between obesity and cancer: the role of Fatty Acid synthase. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22331133&form=6&db=m Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22380770&form=6&db=m Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity. causal interaction,therapeutic application,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22469867&form=6&db=m Therapeutic effects of angiotensin II type 1 receptor blocker, irbesartan, on non-alcoholic steatohepatitis using FLS-ob/ob male mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22485149&form=6&db=m Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22513183&form=6&db=m Dihydroquercetin: More than just an impurity? ongoing research,therapeutic application,unassigned 1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22559865&form=6&db=m New synthetic inhibitors of fatty acid synthase with anticancer activity. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22665482&form=6&db=m Lysophosphatidic acid activates lipogenic pathways and de novo lipid synthesis in ovarian cancer cells. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22676643&form=6&db=m Mulberry Leaf Polyphenol Extract Induced Apoptosis Involving Regulation of Adenosine Monophosphate-Activated Protein Kinase/Fatty Acid Synthase in a p53-Negative Hepatocellular Carcinoma Cell. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22709911&form=6&db=m Expression Status of Fatty Acid Synthase (FAS) but not HER2 is Correlated with the Differentiation Grade and Prognosis of Esophageal Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22722903&form=6&db=m The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22723001&form=6&db=m Fatty acid synthase expression and esophageal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22744755&form=6&db=m Fatty acid synthase is a predictive marker for aggressiveness in meningiomas. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22754424&form=6&db=m Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22767439&form=6&db=m Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22771636&form=6&db=m Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22786746&form=6&db=m Reduced expression of FASN through SREBP-1 down-regulation is responsible for hypoxic cell death in HepG2 cells. causal interaction,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22860766&form=6&db=m Fatty Acid Synthase Regulates Proliferation and Migration of Colorectal Cancer Cells Via HER2-PI3K/Akt Signaling Pathway. causal interaction,ongoing research,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22877747&form=6&db=m Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22892389&form=6&db=m The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22898571&form=6&db=m Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23064941&form=6&db=m Usefulness of immunohistochemical expression analysis of metabolic-related molecules to differentiate between intracranial neoplastic and non-neoplastic lesions. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23065756&form=6&db=m Mollugin inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23108760&form=6&db=m Fatty acid synthase inhibitor cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23135268&form=6&db=m G protein-coupled estrogen receptor mediates the up-regulation of fatty acid synthase induced by 17?-estradiol in cancer cells and cancer-associated fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23141830&form=6&db=m Short communication: Effect of heat stress during the dry period on gene expression in mammary tissue and peripheral blood mononuclear cells. ongoing research,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162615&form=6&db=m Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23181152&form=6&db=m Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23208675&form=6&db=m Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23287468&form=6&db=m The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23302642&form=6&db=m Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation. diagnostic usage,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23317220&form=6&db=m Inhibitory effects of onion (Allium cepa L.) extract on proliferation of cancer cells and adipocytes via inhibiting fatty acid synthase. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441619&form=6&db=m Fatty Acid synthase inhibition induces differential expression of genes involved in apoptosis and cell proliferation in ocular cancer cells. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23470539&form=6&db=m Targeting cellular metabolism to improve cancer therapeutics. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23599729&form=6&db=m Tumor suppressive microRNA-424 inhibits osteosarcoma cell migration and invasion via targeting fatty acid synthase. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23725225&form=6&db=m Loss of fatty acid synthase inhibits the "HER2-PI3K/Akt axis" activity and malignant phenotype of Caco-2 cells. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23741342&form=6&db=m Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23754252&form=6&db=m Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23816424&form=6&db=m Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23821378&form=6&db=m Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23879478&form=6&db=m The expression of fatty acid metabolism-associated proteins is correlated with the prognosis of meningiomas. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23969921&form=6&db=m Extranodal Nasal NK/T-Cell Lymphoma: A Rare Oral Presentation and FASN, CD44 and GLUT-1 Expression. ongoing research,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059230&form=6&db=m Recent Trends in the Design, Synthesis and Biological Exploration of ?-Lactams. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24060750&form=6&db=m Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24200503&form=6&db=m Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity. causal interaction,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337182&form=6&db=m Fatty acid synthase overexpression in adult testicular germ cell tumors: potential role in the progression of non-seminomatous germ cell tumors. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24349275&form=6&db=m Myelopoietic efficacy of orlistat in murine hosts bearing T cell lymphoma: implication in macrophage differentiation and activation. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24362821&form=6&db=m Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24422874&form=6&db=m Increased fatty acid synthase expression in prostate biopsy cores predicts higher Gleason score in radical prostatectomy specimen. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24430360&form=6&db=m Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: correlation with clinical outcomes. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24510238&form=6&db=m Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24527066&form=6&db=m Elevated levels of serum fatty acid synthase in patients with gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24596388&form=6&db=m Prolyl-isomerase Pin1 Impairs Trastuzumab Sensitivity by Up-regulating Fatty Acid Synthase Expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24605027&form=6&db=m Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24643292&form=6&db=m Prognostic Impact of Fatty Acid Synthase Expression in Upper Urinary Tract Urothelial Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24767307&form=6&db=m Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning. diagnostic usage,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24789255&form=6&db=m Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24827738&form=6&db=m Lipogenesis in cancer progression (review). causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24862278&form=6&db=m Methods to assess lipid accumulation in cancer cells. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24900519&form=6&db=m Fatty Acid synthase inhibitors as possible treatment for cancer: patent highlight. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24907642&form=6&db=m Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24957042&form=6&db=m Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959831&form=6&db=m Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24979135&form=6&db=m Up-regulated FASN expression promotes transcoelomic metastasis of ovarian cancer cell through epithelial-mesenchymal transition. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24984811&form=6&db=m Elevated expression of fatty acid synthase and nuclear localization of carnitine palmitoyltransferase 1C are common among human gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25017943&form=6&db=m Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25084411&form=6&db=m Inhibitory effects of four plants flavonoids extracts on fatty acid synthase. diagnostic usage,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25086185&form=6&db=m Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25086508&form=6&db=m A human fatty acid synthase inhibitor binds ?-ketoacyl reductase in the keto-substrate site. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25091112&form=6&db=m Significantly increased monounsaturated lipids relative to polyunsaturated lipids in six types of cancer microenvironment are observed by mass spectrometry imaging. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25117182&form=6&db=m Untargeted mass spectrometry-based metabolomic profiling of pleural effusions: fatty acids as novel cancer biomarkers for malignant pleural effusions. causal interaction,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25155760&form=6&db=m Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25255125&form=6&db=m The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells. ongoing research,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25302649&form=6&db=m Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25309810&form=6&db=m Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase. therapeutic application,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25351207&form=6&db=m Direct visualization of de novo lipogenesis in single living cells. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25351625&form=6&db=m LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the phosphatidylinositol 3?kinase/Akt/fatty acid synthase signaling pathway in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483192&form=6&db=m Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25499031&form=6&db=m Obesity induced rapid melanoma progression is reversed by orlistat treatment and dietary intervention: Role of adipokines. causal interaction,diagnostic usage,unassigned 1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25511512&form=6&db=m Targeting Mitochondrial Citrate Transport in Breast Cancer Cell Lines. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25513712&form=6&db=m Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25565205&form=6&db=m Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25594950&form=6&db=m Regulation of lipid metabolism and peroxisome proliferator-activated receptors in rainbow trout adipose tissue by lipolytic and antilipolytic endocrine factors. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25753425&form=6&db=m M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPAR?/? Activation in Tumor Myeloid Cells, Leading to Tumor Progression. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25766252&form=6&db=m Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers. therapeutic application,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25787885&form=6&db=m Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. ongoing research,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871544&form=6&db=m Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells. therapeutic application,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25895130&form=6&db=m Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis. ongoing research,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25913854&form=6&db=m Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25937841&form=6&db=m FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25947066&form=6&db=m Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25958981&form=6&db=m Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations. therapeutic application,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26043686&form=6&db=m Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26116612&form=6&db=m Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26265485&form=6&db=m Food Shortage Causes Differential Effects on Body Composition and Tissue-Specific Gene Expression in Salmon Modified for Increased Growth Hormone Production. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26288680&form=6&db=m Fatty Acid Synthase (FASN) Inhibitors as Potential Treatment for Cancer, Obesity, and Liver Related Disorders. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26397061&form=6&db=m Therapeutic effects of the dipeptidyl peptidase-IV inhibitor, sitagliptin, on non-alcoholic steatohepatitis in FLS-ob/ob male mice. ongoing research,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26425687&form=6&db=m Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26452216&form=6&db=m L-Carnitine Ameliorates Cancer Cachexia in Mice Partly via the Carnitine Palmitoyltransferase-Associated PPAR-? Signaling Pathway. diagnostic usage,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484401&form=6&db=m Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26567114&form=6&db=m [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26773785&form=6&db=m Adzuki bean ameliorates hepatic lipogenesis and proinflammatory mediator expression in mice fed a high-cholesterol and high-fat diet to induce nonalcoholic fatty liver disease. diagnostic usage,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26824142&form=6&db=m Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26864638&form=6&db=m Natural fatty acid synthase inhibitors as potent therapeutic agents for cancers: A review. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881388&form=6&db=m Lipid Desaturation: the next step in targeting lipogenesis in cancer? therapeutic application,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26936091&form=6&db=m Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26951539&form=6&db=m Prolyl hydroxylase mediated inhibition of fatty acid synthase to combat tumor growth in mammary gland carcinoma. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26980761&form=6&db=m Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26985864&form=6&db=m Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27001279&form=6&db=m Lactobacillus sakei OK67 ameliorates high-fat diet-induced blood glucose intolerance and obesity in mice by inhibiting gut microbiota lipopolysaccharide production and inducing colon tight junction protein expression. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27061087&form=6&db=m Inhibition of fatty acid synthase is protective in pulmonary hypertension. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27139420&form=6&db=m Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145135&form=6&db=m Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27160499&form=6&db=m Ubá mango juices intake decreases adiposity and inflammation in high-fat diet-induced obese Wistar rats. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27209137&form=6&db=m Insulin signaling, inflammation, and lipolysis in subcutaneous adipose tissue of transition dairy cows either overfed energy during the prepartum period or fed a controlled-energy diet. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27264722&form=6&db=m Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27265747&form=6&db=m Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27277576&form=6&db=m Lovastatin, but not orlistat, reduces intestinal polyp volume in an ApcMin/+ mouse model. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27291048&form=6&db=m 1, 3, 6-Trihydroxy-7-methyl-9, 10-anthracenedione isolated from genus Lindera with anti-cancer activity. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27317602&form=6&db=m Adipose tissue biomarkers involved in early resolution of type 2 diabetes after bariatric surgery. ongoing research,therapeutic application,unassigned 1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27343380&form=6&db=m (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27348886&form=6&db=m Lambda cyhalothrin toxicity induces alterations in lipogenic genes and inflammatory factors in rat liver. therapeutic application,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27450794&form=6&db=m High-Dose Linoleic Acid Activated JAK2-STAT3 Signaling Pathway Involved in Cytokine Production and Lipogenesis in Pancreatic Exocrine Cells. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27507602&form=6&db=m N-phenylmaleimides affect adipogenesis and present antitumor activity through reduction of FASN expression. causal interaction,therapeutic application,unassigned 1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27579768&form=6&db=m Leucine deprivation inhibits proliferation and induces apoptosis of human breast cancer cells via fatty acid synthase. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27601543&form=6&db=m Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602772&form=6&db=m c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27641336&form=6&db=m The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713913&form=6&db=m The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27714708&form=6&db=m Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27746256&form=6&db=m Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27758890&form=6&db=m Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27791122&form=6&db=m FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-?B and SP1. diagnostic usage,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27867269&form=6&db=m Platyphylloside Isolated From Betula platyphylla Inhibit Adipocyte Differentiation and Induce Lipolysis Via Regulating Adipokines Including PPAR? in 3T3-L1 Cells. causal interaction,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884752&form=6&db=m Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer. diagnostic usage,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27889747&form=6&db=m Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells. diagnostic usage,therapeutic application,unassigned 1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27901292&form=6&db=m Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75. causal interaction,therapeutic application,unassigned 4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28146130&form=6&db=m Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). therapeutic application,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28197637&form=6&db=m Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1?/IGFBP1 pathway. causal interaction,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28202364&form=6&db=m Fatty acid synthase - Modern tumor cell biology insights into a classical oncology target. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28236510&form=6&db=m A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28240737&form=6&db=m Fatty acid synthase regulates estrogen receptor-? signaling in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386270&form=6&db=m Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPAR? Regulation in Hyperlipidemic and Hypertensive Conditions. ongoing research,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28387458&form=6&db=m Anti-Tumorigenic Potential of a Novel Orlistat-AICAR Combination in Prostate Cancer Cells. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28427229&form=6&db=m NADPH accumulation is responsible for apoptosis in breast cancer cells induced by fatty acid synthase inhibition. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28442505&form=6&db=m Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28483521&form=6&db=m Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28565856&form=6&db=m Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3-kinase/protein kinase B signaling pathway in xenograft models. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588696&form=6&db=m MAPK/P53-mediated FASN expression in bone tumors. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28615298&form=6&db=m Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28726934&form=6&db=m Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28839361&form=6&db=m Ethanolic Fraction of Terminalia tomentosa Attenuates Biochemical and Physiological Derangements in Diet Induced Obese Rat Model by Regulating Key Lipid Metabolizing Enzymes and Adipokines. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28848043&form=6&db=m Fatty acid synthase regulates the pathogenicity of Th17 cells. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28871635&form=6&db=m Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29112683&form=6&db=m Targeting de novo lipogenesis as a novel approach in anti-cancer therapy. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29130104&form=6&db=m Expression of fatty acid synthase is regulated by PGC?1? and contributes to increased cell proliferation. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29334602&form=6&db=m High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29407795&form=6&db=m Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer. causal interaction,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29409330&form=6&db=m Bifidobacteria and its rice fermented products on diet induced obese mice: analysis of physical status, serum profile and gene expressions. diagnostic usage,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29449607&form=6&db=m 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29569717&form=6&db=m The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29588626&form=6&db=m Epistructured catechins, EGCG and EC facilitate apoptosis induction through targeting de novo lipogenesis pathway in HepG2 cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29681001&form=6&db=m Immunohistochemical Expression of Fatty Acid Synthase and Vascular Endothelial Growth Factor in Primary Colorectal Cancer: a Clinicopathological Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29723075&form=6&db=m Orlistat as a FASN inhibitor and multitargeted agent for cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29779975&form=6&db=m Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872506&form=6&db=m Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29906537&form=6&db=m Phenolic acid and flavonoid-rich fraction of Sasa quelpaertensis Nakai leaves prevent alcohol induced fatty liver through AMPK activation. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928446&form=6&db=m Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30154249&form=6&db=m De Novo Fatty Acid Synthesis-Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30205135&form=6&db=m Kahweol inhibits proliferation and induces apoptosis by suppressing fatty acid synthase in HER2-overexpressing cancer cells. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30256698&form=6&db=m In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,2 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30283446&form=6&db=m Gene Expression Analysis Identifies Novel Targets for Cervical Cancer Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30372889&form=6&db=m Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines. ongoing research,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30465055&form=6&db=m Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30520016&form=6&db=m Impact of systemic and tumor lipid metabolism on everolimus efficacy in advanced pancreatic neuroendocrine tumors (pNETs). diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30537241&form=6&db=m Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580553&form=6&db=m n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. ongoing research,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30597641&form=6&db=m Fatty acid synthase and Ki-67 immunoexpression can be useful for the identification of malignant component in carcinoma ex-pleomorphic adenoma. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30619288&form=6&db=m Ovarian Cancer-Intrinsic Fatty Acid Synthase Prevents Anti-tumor Immunity by Disrupting Tumor-Infiltrating Dendritic Cells. causal interaction,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30622377&form=6&db=m Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30667213&form=6&db=m Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30741424&form=6&db=m Antitumor effects of curcumin: A lipid perspective. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30944506&form=6&db=m Immunohistochemical investigation of metabolic markers fatty acid synthase (FASN) and glucose transporter 1 (GLUT1) in normal endometrium, endometrial hyperplasia, and endometrial malignancy. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30948220&form=6&db=m Laparoscopic sleeve gastrectomy induces molecular changes in peripheral white blood cells. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118679&form=6&db=m MEX3C regulates lipid metabolism to promote bladder tumorigenesis through JNK pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31154466&form=6&db=m PHD-2 activation: a novel strategy to control HIF-1? and mitochondrial stress to modulate mammary gland pathophysiology in ER+ subtype. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31279605&form=6&db=m Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31299104&form=6&db=m Osajin displays potential antiprostate cancer efficacy via impairment of fatty acid synthase and androgen receptor expression. causal interaction,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31300609&form=6&db=m An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31377611&form=6&db=m Mitochondrial targeting nano-curcumin for attenuation on PKM2 and FASN. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31676791&form=6&db=m Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells. causal interaction,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31738794&form=6&db=m Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis. causal interaction,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31784059&form=6&db=m Bioactive ingredients obtained from Cortex Fraxini impair interactions between FAS and GPI. ongoing research,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31838869&form=6&db=m Nelumbo nucifera Leaves Prevent NMU-Induced Mammary Tumor through Downregulation of Fatty Acid Synthase, Estrogen Receptor-? and Her2 Expression. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31863126&form=6&db=m The antimetastatic activity of orlistat is accompanied by an antitumoral immune response in mouse melanoma. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889469&form=6&db=m Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan. therapeutic application,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894270&form=6&db=m Association between different levels of lipid metabolism?related enzymes and fatty acid synthase in Wilms' tumor. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31904263&form=6&db=m Fatty acid synthase is a prognostic marker and associated with immune infiltrating in gastric cancers precision medicine. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31927122&form=6&db=m MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32045588&form=6&db=m Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met. therapeutic application,unassigned 4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32053360&form=6&db=m Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32093357&form=6&db=m Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139877&form=6&db=m Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32158923&form=6&db=m Emerging role of Fatty acid synthase in tumor initiation: implications for cancer prevention. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32197133&form=6&db=m Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32577118&form=6&db=m Antiobesity and anti-inflammation effects of Hakka stir-fried tea of different storage years on high-fat diet-induced obese mice model via activating the AMPK/ACC/CPT1 pathway. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640537&form=6&db=m Viburnum opulus L. Juice Phenolics Inhibit Mouse 3T3-L1 Cells Adipogenesis and Pancreatic Lipase Activity. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32685475&form=6&db=m Cucurbita ficifolia Fruit Extract Induces Tp53/Caspase-Mediated Apoptosis in MCF-7 Breast Cancer Cells. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32698885&form=6&db=m Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32699531&form=6&db=m Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32820613&form=6&db=m Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/?-catenin pathway. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850342&form=6&db=m Inhibition of Fatty Acid Synthase Upregulates Expression of CD36 to Sustain Proliferation of Colorectal Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32872164&form=6&db=m Fatty Acid Synthase: An Emerging Target in Cancer. causal interaction,therapeutic application,unassigned 2,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32961983&form=6&db=m Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck. diagnostic usage,ongoing research,unassigned 4,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33027752&form=6&db=m Expression and prognostic significance of fatty acid synthase in clear cell renal cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043786&form=6&db=m Exploring a role for fatty acid synthase in prostate cancer cell migration. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33083663&form=6&db=m Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33112541&form=6&db=m Higher Level of Fatty Acid Synthase Enzyme Predicts Lower Rate of Completing Debulking Surgery in Epithelial Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33121001&form=6&db=m Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33182594&form=6&db=m Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33190588&form=6&db=m TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. ongoing research,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33209199&form=6&db=m Arachidonic acid induces ER stress and apoptosis in HT-29 human colon cancer cells. diagnostic usage,therapeutic application,unassigned 2,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33226729&form=6&db=m Autophagy activation and SREBP-1 induction contribute to fatty acid metabolic reprogramming by leptin in breast cancer cells. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33240433&form=6&db=m Fatty acid synthase promotes breast cancer metastasis by mediating changes in fatty acid metabolism. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33261004&form=6&db=m Synergistic Effect of Omega-3 Fatty Acids and Oral-Hypoglycemic Drug on Lipid Normalization through Modulation of Hepatic Gene Expression in High Fat Diet with Low Streptozotocin-Induced Diabetic Rats. ongoing research,unassigned 1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33281535&form=6&db=m Bile salt hydrolase-overexpressing Lactobacillus strains can improve hepatic lipid accumulation in vitro in an NAFLD cell model. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33324084&form=6&db=m Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice. ongoing research,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33405298&form=6&db=m iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33742137&form=6&db=m Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33754444&form=6&db=m Anti-Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy. causal interaction,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33761444&form=6&db=m Sodium acetate, propionate, and butyrate reduce fat accumulation in mice via modulating appetite and relevant genes. causal interaction,diagnostic usage,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33843033&form=6&db=m Immunohistochemical Expression of Fatty Acid Synthase (FASN) is Correlated to Tumor Aggressiveness and Cellular Differentiation in Salivary Gland Carcinomas. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33870151&form=6&db=m First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors. therapeutic application,unassigned 3,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33893909&form=6&db=m FASN inhibition as a potential treatment for endocrine-resistant breast cancer. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33992387&form=6&db=m Potential mechanistic pathways underlying intestinal and hepatic effects of kefir in high-fructose-fed rats. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34046694&form=6&db=m Dual regulation of fatty acid synthase (FASN) expression by O-GlcNAc transferase (OGT) and mTOR pathway in proliferating liver cancer cells. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149876&form=6&db=m Co-administration of obeticholic acid and simvastatin protects against high-fat diet-induced non-alcoholic steatohepatitis in mice. diagnostic usage,ongoing research,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34159140&form=6&db=m Molecular dynamics simulation of Fe-NO2 At-alpha mangostin as radiopharmaceutical model for detection of fatty acid synthase in cancer. diagnostic usage,therapeutic application,unassigned 3,1,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34321955&form=6&db=m Lipid metabolism in cancer: A systematic review. unassigned - 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34374658&form=6&db=m Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease in mice. ongoing research,unassigned 2,0 2.3.1.39 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34421595&form=6&db=m Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression. therapeutic application,unassigned 1,0 2.3.1.39 Neoplasms, Germ Cell and Embryonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337182&form=6&db=m Fatty acid synthase overexpression in adult testicular germ cell tumors: potential role in the progression of non-seminomatous germ cell tumors. causal interaction,unassigned 4,0 2.3.1.39 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7723242&form=6&db=m Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion. ongoing research,unassigned 2,0 2.3.1.39 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12820377&form=6&db=m Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20053345&form=6&db=m 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. ongoing research,unassigned 1,0 2.3.1.39 Neurofibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26116612&form=6&db=m Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors. causal interaction,unassigned 3,0 2.3.1.39 Nevi and Melanomas http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21819495&form=6&db=m Expression of fatty acid synthase (FASN) in oral nevi and melanoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15467715&form=6&db=m Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis. causal interaction,unassigned 3,0 2.3.1.39 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15920554&form=6&db=m Fatty acid synthase expression in cutaneous melanocytic neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.39 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21819495&form=6&db=m Expression of fatty acid synthase (FASN) in oral nevi and melanoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28654463&form=6&db=m Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi. therapeutic application,unassigned 1,0 2.3.1.39 Nevus, Epithelioid and Spindle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15467715&form=6&db=m Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis. causal interaction,unassigned 3,0 2.3.1.39 Nevus, Pigmented http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15467715&form=6&db=m Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis. causal interaction,unassigned 3,0 2.3.1.39 Nevus, Pigmented http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15920554&form=6&db=m Fatty acid synthase expression in cutaneous melanocytic neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0 2.3.1.39 Nevus, Pigmented http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21819495&form=6&db=m Expression of fatty acid synthase (FASN) in oral nevi and melanoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18395287&form=6&db=m Fructose consumption as a risk factor for non-alcoholic fatty liver disease. unassigned - 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19054139&form=6&db=m Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19231010&form=6&db=m Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. unassigned - 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20606731&form=6&db=m Expression of fatty acid synthase in nonalcoholic fatty liver disease. ongoing research,unassigned 2,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20929443&form=6&db=m Enhanced expression of pro-inflammatory mediators and liver X receptor-regulated lipogenic genes in nonalcoholic fatty liver disease and hepatitits C. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22648174&form=6&db=m Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet. ongoing research,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23127599&form=6&db=m Alleviative effects of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23791610&form=6&db=m Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated receptor alpha (Ppar?). causal interaction,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24335764&form=6&db=m Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24678767&form=6&db=m Terminalia paniculata bark extract attenuates nonalcoholic fatty liver via down regulation of fatty acid synthase in high fat diet-fed obese rats. causal interaction,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26681923&form=6&db=m A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis. causal interaction,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27445343&form=6&db=m A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. unassigned - 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27852305&form=6&db=m Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice. ongoing research,unassigned 3,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28146130&form=6&db=m Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). therapeutic application,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539716&form=6&db=m Prevention Mechanism of 2,3,5,4'-Tetrahydroxy-stilbene-2-O-?-D-glucoside on Lipid Accumulation in Steatosis Hepatic L-02 Cell. unassigned - 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28827398&form=6&db=m Network analyses identify liver-specific targets for treating liver diseases. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29717275&form=6&db=m Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers. diagnostic usage,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30109054&form=6&db=m Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats. causal interaction,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580553&form=6&db=m n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. ongoing research,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30802722&form=6&db=m Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-? and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet. ongoing research,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31110049&form=6&db=m FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31913745&form=6&db=m SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. ongoing research,unassigned 2,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31978277&form=6&db=m Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. unassigned - 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007939&form=6&db=m Erratum: FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice. ongoing research,unassigned 2,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32228319&form=6&db=m Downregulated microRNA-130b-5p prevents lipid accumulation and insulin resistance in a murine model of nonalcoholic fatty liver disease. ongoing research,unassigned 3,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33190588&form=6&db=m TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. ongoing research,unassigned 1,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33289350&form=6&db=m Inhibition of fatty acid synthase with FT-4101 safely reduces hepatic de novo lipogenesis and steatosis in obese subjects with non-alcoholic fatty liver disease: Results from two early-phase randomized trials. ongoing research,therapeutic application,unassigned 2,3,0 2.3.1.39 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34231239&form=6&db=m Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD. therapeutic application,unassigned 1,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9575816&form=6&db=m Properties and purification of a glucose-inducible human fatty acid synthase mRNA-binding protein. ongoing research,unassigned 4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11739082&form=6&db=m Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060712&form=6&db=m C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15235125&form=6&db=m Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15307831&form=6&db=m Fatty acid synthase blockade protects steatotic livers from warm ischemia reperfusion injury and transplantation. therapeutic application,unassigned 2,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15694180&form=6&db=m Obesity, fatty acid synthase, and cancer: serendipity or forgotten causal linkage? unassigned - 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15793852&form=6&db=m A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse. diagnostic usage,unassigned 3,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16611078&form=6&db=m Inhibition of fatty acid synthase by polyphenols. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16870425&form=6&db=m Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17492427&form=6&db=m Fatty acid synthase gene expression in human adipose tissue: association with obesity and type 2 diabetes. causal interaction,ongoing research,unassigned 4,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17563462&form=6&db=m Endocannabinoid system in cancer cachexia. ongoing research,unassigned 2,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17847090&form=6&db=m Molecular docking study of the interactions between the thioesterase domain of human fatty acid synthase and its ligands. therapeutic application,unassigned 2,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18380011&form=6&db=m The novel inhibitory effect of Pangdahai on fatty acid synthase. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18452391&form=6&db=m A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production. therapeutic application,unassigned 4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18583073&form=6&db=m Parasitic loranthus from Loranthaceae rather than Viscaceae potently inhibits fatty acid synthase and reduces body weight in mice. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19531664&form=6&db=m A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays. causal interaction,unassigned 3,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19876008&form=6&db=m Effect of Genetic Variation in the Human Fatty Acid Synthase Gene (FASN) on Obesity and Fat Depot-Specific mRNA Expression. ongoing research,unassigned 4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20544979&form=6&db=m Fatty acid synthase inhibitory activity of dibenzocyclooctadiene lignans isolated from Schisandra chinensis. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20799351&form=6&db=m Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity. unassigned - 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20817450&form=6&db=m Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21605850&form=6&db=m Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L. causal interaction,therapeutic application,unassigned 3,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21752639&form=6&db=m Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22100592&form=6&db=m Relationship of polymorphisms within metabolic genes and carcass traits in crossbred beef cattle. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22312133&form=6&db=m Associations between obesity and cancer: the role of Fatty Acid synthase. causal interaction,ongoing research,unassigned 1,2,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22767439&form=6&db=m Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu (erbB2) Oncogene in SKBR3 Human Breast Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22840209&form=6&db=m Potential predictive biomarkers of obesity in Burmese cats. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23057325&form=6&db=m [Study on the weight-reducing effect of Acer truncatum leave extract in alimentary obesity rat]. ongoing research,unassigned 3,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376793&form=6&db=m Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24335764&form=6&db=m Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25155760&form=6&db=m Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25173531&form=6&db=m Fatty acid synthase/oxidized low-density lipoprotein as metabolic oncogenes linking obesity to colon cancer via NF-kappa B in Egyptians. diagnostic usage,ongoing research,unassigned 2,1,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26035182&form=6&db=m Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6-methylguanine-DNA methyltransferase in human normal or malignant cells in vitro. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26035386&form=6&db=m Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice. unassigned - 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26288680&form=6&db=m Fatty Acid Synthase (FASN) Inhibitors as Potential Treatment for Cancer, Obesity, and Liver Related Disorders. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26321743&form=6&db=m The modulating effect of Persea americana fruit extract on the level of expression of fatty acid synthase complex, lipoprotein lipase, fibroblast growth factor-21 and leptin--A biochemical study in rats subjected to experimental hyperlipidemia and obesity. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26930155&form=6&db=m Hypolipidemic Activity of Peony Seed Oil Rich in ?-Linolenic, is Mediated Through Inhibition of Lipogenesis and Upregulation of Fatty Acid ?-Oxidation. unassigned - 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27768648&form=6&db=m Epigenetic Mediators Between Childhood Socioeconomic Disadvantage and Mid-Life Body Mass Index: The New England Family Study. unassigned - 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28726934&form=6&db=m Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28752043&form=6&db=m Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming. unassigned - 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29097254&form=6&db=m Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes. therapeutic application,unassigned 1,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30211075&form=6&db=m Risk association, linkage disequilibrium and haplotype analyses of FASN rs4246445, rs2229425, rs2228305 and rs2229422 polymorphisms in overweight and obesity. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31287803&form=6&db=m Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31492533&form=6&db=m Synthesis, biological activities, and docking studies of d-pantolactone derivatives as novel FAS inhibitors. causal interaction,therapeutic application,unassigned 1,4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31905919&form=6&db=m Phenolic Compounds and the Anti-Atherogenic Effect of Bee Bread in High-Fat Diet-Induced Obese Rats. unassigned - 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32255372&form=6&db=m Dietary calcium regulates the risk renal injury in high fat diet induced obese rats by regulating renal lipid metabolism, oxidative stress and inflammation. unassigned - 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33273564&form=6&db=m Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters. unassigned - 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33424396&form=6&db=m Regulatory effect of diosgenin on lipogenic genes expression in high-fat diet-induced obesity in mice. ongoing research,unassigned 4,0 2.3.1.39 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616223&form=6&db=m The gene expression of long non-coding RNAs (lncRNAs): MEG3 and H19 in adipose tissues from obese women and its association with insulin resistance and obesity indices. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.3.1.39 Optic Nerve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31915829&form=6&db=m Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy. causal interaction,unassigned 3,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530413&form=6&db=m Gene expression analysis by cDNA microarray in oral cancers from two Western populations. unassigned - 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22771636&form=6&db=m Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration. causal interaction,ongoing research,unassigned 4,1,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162615&form=6&db=m Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162665&form=6&db=m microRNA-195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23229760&form=6&db=m Inhibition of fatty acid synthase suppresses osteosarcoma cell invasion and migration via downregulation of the PI3K/Akt signaling pathway in vitro. causal interaction,ongoing research,unassigned 4,2,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23599729&form=6&db=m Tumor suppressive microRNA-424 inhibits osteosarcoma cell migration and invasion via targeting fatty acid synthase. unassigned - 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24366211&form=6&db=m Positive feedback regulation between Akt phosphorylation and fatty acid synthase expression in osteosarcoma. causal interaction,unassigned 2,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24390663&form=6&db=m MicroRNA-320 inhibits osteosarcoma cells proliferation by directly targeting fatty acid synthase. ongoing research,unassigned 1,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25674245&form=6&db=m Interaction between fatty acid synthase and human epidermal growth receptor 2 (HER2) in osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28565856&form=6&db=m Blocking fatty acid synthase inhibits tumor progression of human osteosarcoma by regulating the human epidermal growth factor receptor 2/phosphoinositide 3-kinase/protein kinase B signaling pathway in xenograft models. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31404800&form=6&db=m Acetone immersion enhanced MALDI-MS imaging of small molecule metabolites in biological tissues. ongoing research,unassigned 1,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33289496&form=6&db=m Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells. causal interaction,unassigned 3,0 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33405298&form=6&db=m iTRAQ-based proteomic analysis of the molecular mechanisms and downstream effects of fatty acid synthase in osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1 2.3.1.39 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34456997&form=6&db=m FASN Knockdown Inhibited Anoikis Resistance of Gastric Cancer Cells via P-ERK1/2/Bcl-xL Pathway. unassigned - 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9191002&form=6&db=m Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032949&form=6&db=m Immunohistochemical study of fatty acid synthase in ovarian neoplasms. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15806173&form=6&db=m Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409402&form=6&db=m Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20511185&form=6&db=m Fatty acid synthase as a novel target for meningioma therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21970855&form=6&db=m Blockade of fatty acid synthase induces ubiquitination and degradation of phosphoinositide-3-kinase signaling proteins in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25151963&form=6&db=m Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25302649&form=6&db=m Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433947&form=6&db=m Expressions of fatty acid synthase and HER2 are correlated with poor prognosis of ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25947066&form=6&db=m Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26985864&form=6&db=m Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28086243&form=6&db=m Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells. therapeutic application,unassigned 4,0 2.3.1.39 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31372520&form=6&db=m Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells. causal interaction,therapeutic application,unassigned 3,2,0 2.3.1.39 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15303106&form=6&db=m Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans. causal interaction,unassigned 2,0 2.3.1.39 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21570880&form=6&db=m Lipogenic gene expression in abdominal adipose and liver tissues of diet-induced overweight cats. diagnostic usage,ongoing research,unassigned 1,3,0 2.3.1.39 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27317873&form=6&db=m Adipocytes contribute to the growth and progression of multiple myeloma: Unraveling obesity related differences in adipocyte signaling. unassigned - 2.3.1.39 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30211075&form=6&db=m Risk association, linkage disequilibrium and haplotype analyses of FASN rs4246445, rs2229425, rs2228305 and rs2229422 polymorphisms in overweight and obesity. diagnostic usage,ongoing research,unassigned 1,2,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21331354&form=6&db=m Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21727995&form=6&db=m Serum Levels of Fatty Acid Synthase in Colorectal Cancer Patients Are Associated with Tumor Stage. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801966&form=6&db=m Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23803693&form=6&db=m Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors. therapeutic application,unassigned 1,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26043686&form=6&db=m Up-regulation of fatty acid synthase induced by EGFR/ERK activation promotes tumor growth in pancreatic cancer. causal interaction,unassigned 3,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28483521&form=6&db=m Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28639885&form=6&db=m MicroRNA-195 inhibits the proliferation and invasion of pancreatic cancer cells by targeting the fatty acid synthase/Wnt signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28811332&form=6&db=m De Novo Lipid Synthesis facilitates Gemcitabine Resistance Through Endoplasmic Reticulum Stress In Pancreatic Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29061815&form=6&db=m Orlistat Reduces Proliferation and Enhances Apoptosis in Human Pancreatic Cancer Cells (PANC-1). ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29434927&form=6&db=m Upregulation of pyruvate kinase M2 expression by fatty acid synthase contributes to gemcitabine resistance in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 2.3.1.39 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33538066&form=6&db=m Palbociclib negatively regulates fatty acid synthesis due to upregulation of AMPK? and miR-33a levels to increase apoptosis in Panc-1 and MiaPaCa-2 cells. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32826925&form=6&db=m Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.3.1.39 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33239671&form=6&db=m Publisher Correction: Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8665507&form=6&db=m Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8816886&form=6&db=m Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9067276&form=6&db=m Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9494573&form=6&db=m Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9699873&form=6&db=m Androgens and the control of lipid metabolism in human prostate cancer cells. causal interaction,therapeutic application,unassigned 4,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11004665&form=6&db=m Selective activation of the fatty acid synthesis pathway in human prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11340632&form=6&db=m Increased fatty acid synthase as a therapeutic target in androgen-independent prostate cancer progression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830512&form=6&db=m Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857379&form=6&db=m Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12238242&form=6&db=m [Androgens and increased lipogenesis in prostate cancer. Cell biologic and clinical perspectives] unassigned - 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750860&form=6&db=m Large-scale analysis of HLA peptides presented by HLA-Cw4. diagnostic usage,unassigned 1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12798352&form=6&db=m Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells. diagnostic usage,unassigned 1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839976&form=6&db=m RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12918062&form=6&db=m Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939396&form=6&db=m Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14518031&form=6&db=m Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14963012&form=6&db=m Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15050917&form=6&db=m The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15533929&form=6&db=m Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15556626&form=6&db=m Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870086&form=6&db=m Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. therapeutic application,unassigned 4,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880754&form=6&db=m High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16798056&form=6&db=m Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16905103&form=6&db=m Structural basis of ubiquitin recognition by the deubiquitinating protease USP2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17477363&form=6&db=m Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786030&form=6&db=m Caveolin-1 is Required for the Upregulation of Fatty Acid Synthase (FASN), a Tumor Promoter, During Prostate Cancer Progression. causal interaction,diagnostic usage,unassigned 4,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199615&form=6&db=m 1-11C-acetate as a PET radiopharmaceutical for imaging fatty acid synthase expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18355682&form=6&db=m Examining the relationship between Cu-ATSM hypoxia selectivity and fatty acid synthase expression in human prostate cancer cell lines. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18774944&form=6&db=m KLF5 enhances SREBP-1 action in androgen-dependent induction of fatty acid synthase in prostate cancer cells. diagnostic usage,unassigned 2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18817351&form=6&db=m [Fatty acid synthase and prostate cancer] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18838960&form=6&db=m Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19318631&form=6&db=m Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19795124&form=6&db=m [Immunohistochemical algorithms in prostate diagnostics : What's new?] causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043266&form=6&db=m The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20546348&form=6&db=m Comparison of the diagnostic value of fatty acid synthase (FASN) with alpha-methylacyl-CoA racemase (AMACR) as prostatic cancer tissue marker. diagnostic usage,ongoing research,unassigned 3,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20679621&form=6&db=m Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20965718&form=6&db=m Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21041072&form=6&db=m Expression and vitamin D(3) regulation of long-chain fatty-acid-CoA ligase 3 in human prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21082686&form=6&db=m Metabolic alterations and targeted therapies in prostate cancer. causal interaction,unassigned 2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21125681&form=6&db=m Metabolic alterations and targeted therapies in prostate cancer. causal interaction,unassigned 2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21170507&form=6&db=m Thiazolidinediones/PPAR? agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21762084&form=6&db=m Mouse Prostate Proteome Changes Induced by Oral Pentagalloylglucose Treatment Suggest Targets for Cancer Chemoprevention. causal interaction,therapeutic application,unassigned 3,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21796538&form=6&db=m Analysis of androgen-induced increase in lipid accumulation in prostate cancer cells. causal interaction,unassigned 3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022994&form=6&db=m Targeting Sp1 transcription factors in prostate cancer therapy. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127986&form=6&db=m Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23741342&form=6&db=m Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23951060&form=6&db=m MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells. ongoing research,unassigned 3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24907642&form=6&db=m Novel nuclear localization of fatty acid synthase correlates with prostate cancer aggressiveness. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25313139&form=6&db=m The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. diagnostic usage,therapeutic application,unassigned 1,4,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26282590&form=6&db=m Evaluation of fatty acid synthase in prostate cancer recurrence: SUV of [(11) C]acetate PET as a prognostic marker. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,1 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484401&form=6&db=m Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26878389&form=6&db=m Diet-induced alteration of fatty acid synthase in prostate cancer progression. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26894509&form=6&db=m Targeting fatty acid synthase with ASC-J9 suppresses proliferation and invasion of prostate cancer cells. causal interaction,unassigned 4,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26929070&form=6&db=m Metabolic and molecular regulation of dietary polyunsaturated fatty acids on prostate cancer. unassigned - 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26934656&form=6&db=m P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27471561&form=6&db=m Proteomic Upregulation of Fatty Acid Synthase and Fatty Acid Binding Protein 5 and Identification of Cancer- and Race-Specific Pathway Associations in Human Prostate Cancer Tissues. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28143451&form=6&db=m Distinct prostate cancer-related mRNA cargo in extracellular vesicle subsets from prostate cell lines. causal interaction,diagnostic usage,unassigned 1,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088813&form=6&db=m Hypoxia negates hyperglycaemia-induced chemo-resistance in breast cancer cells: the role of insulin-like growth factor binding protein 2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29449607&form=6&db=m 6-Thioguanine is a noncompetitive and slow binding inhibitor of human deubiquitinating protease USP2. unassigned - 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29668854&form=6&db=m Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism. unassigned - 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30242113&form=6&db=m CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30578319&form=6&db=m Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. unassigned - 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30955223&form=6&db=m Speckle-type POZ protein suppresses lipid accumulation and prostate cancer growth by stabilizing fatty acid synthase. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31527721&form=6&db=m Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-?B Pathway. causal interaction,diagnostic usage,unassigned 4,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31831821&form=6&db=m FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. unassigned - 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32093357&form=6&db=m Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32111826&form=6&db=m Macropinocytosis confers resistance to therapies targeting cancer anabolism. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32139877&form=6&db=m Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32258129&form=6&db=m Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study. therapeutic application,unassigned 1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655718&form=6&db=m FASN Protein Overexpression Indicates Poor Biochemical Recurrence-Free Survival in Prostate Cancer. diagnostic usage,therapeutic application,unassigned 4,1,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33043786&form=6&db=m Exploring a role for fatty acid synthase in prostate cancer cell migration. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33083663&form=6&db=m Cytotoxicity and Radiosensitizing Activity of the Fatty Acid Synthase Inhibitor C75 Is Enhanced by Blocking Fatty Acid Uptake in Prostate Cancer Cells. unassigned - 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33182594&form=6&db=m Deciphering Fatty Acid Synthase Inhibition-Triggered Metabolic Flexibility in Prostate Cancer Cells through Untargeted Metabolomics. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.39 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33876336&form=6&db=m Propionic Acid-Based PET Imaging of Prostate Cancer. diagnostic usage,ongoing research,unassigned 3,2,0 2.3.1.39 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7723242&form=6&db=m Plasma triglyceride levels are higher in nephrotic than in analbuminemic rats despite a similar increase in hepatic triglyceride secretion. ongoing research,unassigned 2,0 2.3.1.39 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19357177&form=6&db=m Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney. ongoing research,unassigned 1,0 2.3.1.39 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19878707&form=6&db=m Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. therapeutic application,unassigned 1,0 2.3.1.39 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32041783&form=6&db=m 4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis. therapeutic application,unassigned 3,0 2.3.1.39 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34457121&form=6&db=m The Emerging Role of Fatty Acid Synthase in Hypoxia-Induced Pulmonary Hypertensive Mouse Energy Metabolism. causal interaction,unassigned 1,0 2.3.1.39 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889469&form=6&db=m Can high-intensity interval training improve physical and mental health outcomes? A meta-review of 33 systematic reviews across the lifespan. therapeutic application,unassigned 1,0 2.3.1.39 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15307831&form=6&db=m Fatty acid synthase blockade protects steatotic livers from warm ischemia reperfusion injury and transplantation. therapeutic application,unassigned 2,0 2.3.1.39 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321376&form=6&db=m Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision. therapeutic application,unassigned 1,0 2.3.1.39 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12766036&form=6&db=m Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0 2.3.1.39 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12820377&form=6&db=m Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21111730&form=6&db=m Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0 2.3.1.39 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23181152&form=6&db=m Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2 2.3.1.39 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441619&form=6&db=m Fatty Acid synthase inhibition induces differential expression of genes involved in apoptosis and cell proliferation in ocular cancer cells. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.39 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23816424&form=6&db=m Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors. unassigned - 2.3.1.39 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25958981&form=6&db=m Global gene deregulations in FASN silenced retinoblastoma cancer cells: molecular and clinico-pathological correlations. therapeutic application,unassigned 1,0 2.3.1.39 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885322&form=6&db=m The double dealing of cyclin D1. therapeutic application,unassigned 1,0 2.3.1.39 Rhabdoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12820377&form=6&db=m Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines. ongoing research,therapeutic application,unassigned 4,1,0 2.3.1.39 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12796387&form=6&db=m Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas. causal interaction,diagnostic usage,unassigned 1,4,0 2.3.1.39 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25574840&form=6&db=m UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. unassigned - 2.3.1.39 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26216747&form=6&db=m Inhibition of lipogenesis reduces inflammation and organ injury in sepsis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0 2.3.1.39 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427815&form=6&db=m Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. ongoing research,unassigned 1,0 2.3.1.39 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427815&form=6&db=m Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation. ongoing research,unassigned 1,0 2.3.1.39 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25913854&form=6&db=m Epigallocatechin-3-gallate treatment reduces thermal hyperalgesia after spinal cord injury by down-regulating RhoA expression in mice. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.39 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172638&form=6&db=m Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 2.3.1.39 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18528705&form=6&db=m Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 2.3.1.39 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362044&form=6&db=m Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.39 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20604875&form=6&db=m ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 2.3.1.39 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24362464&form=6&db=m The Fatty Acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas. causal interaction,therapeutic application,unassigned 1,3,0 2.3.1.39 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28871635&form=6&db=m Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,4,0 2.3.1.39 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32197133&form=6&db=m Anticancer properties of the fatty acid synthase inhibitor TVB-3166 on oral squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0 2.3.1.39 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34510641&form=6&db=m FASN inhibition sensitizes metastatic OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1. ongoing research,therapeutic application,unassigned 3,4,0 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1979951&form=6&db=m Age-dependent hepatic lipogenic enzyme activities in starved-refed rats. diagnostic usage,ongoing research,unassigned 1,1,0 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2170411&form=6&db=m Triiodothyronine stimulates transcription of the fatty acid synthase gene in chick embryo hepatocytes in culture. Insulin and insulin-like growth factor amplify that effect. therapeutic application,unassigned 1,0 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2327966&form=6&db=m Dietary-induced pre-translational control of rat fatty acid synthase. ongoing research,unassigned 4,0 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005324&form=6&db=m The fatty acid synthase gene in avian liver. Two mRNAs are expressed and regulated in parallel by feeding, primarily at the level of transcription. diagnostic usage,unassigned 1,0 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3541753&form=6&db=m Regulation of genes for enzymes involved in fatty acid synthesis. unassigned - 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6661215&form=6&db=m The effect of starvation and refeeding on lipogenic enzymes in mammary glands and livers of lactating rats. unassigned - 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6712247&form=6&db=m Malic enzyme and fatty acid synthase in the uropygial gland and liver of embryonic and neonatal ducklings. Tissue-specific regulation of gene expression. unassigned - 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8262967&form=6&db=m Tracing intracellular proteolytic pathways. Proteolysis of fatty acid synthase and other cytoplasmic proteins in the yeast Saccharomyces cerevisiae. diagnostic usage,unassigned 3,0 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8598545&form=6&db=m High carbohydrate diet and starvation regulate lipogenic mRNA in rats in a tissue-specific manner. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9530133&form=6&db=m Glucose stimulates transcription of fatty acid synthase and malic enzyme in avian hepatocytes. unassigned - 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11689692&form=6&db=m Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25605918&form=6&db=m Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast. unassigned - 2.3.1.39 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26954191&form=6&db=m Effects of Starvation on Lipid Metabolism and Gluconeogenesis in Yak. causal interaction,diagnostic usage,unassigned 4,3,0 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11903600&form=6&db=m Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15051923&form=6&db=m Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15459486&form=6&db=m Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis. diagnostic usage,ongoing research,unassigned 4,4,0 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24527066&form=6&db=m Elevated levels of serum fatty acid synthase in patients with gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26514456&form=6&db=m Expression of Fatty Acid Synthase Negatively Correlates with PTEN and Predicts Peritoneal Dissemination of Human Gastric Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622804&form=6&db=m A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients. causal interaction,diagnostic usage,unassigned 3,2,0 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26936091&form=6&db=m Overexpression of fatty acid synthase predicts a poor prognosis for human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884752&form=6&db=m Quantitative proteomic analysis reveals that proteins required for fatty acid metabolism may serve as diagnostic markers for gastric cancer. diagnostic usage,unassigned 3,0 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28180141&form=6&db=m Identification of diagnostic markers involved in the pathogenesis of gastric cancer through iTRAQ-based quantitative proteomics. diagnostic usage,unassigned 3,0 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928446&form=6&db=m Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway. causal interaction,ongoing research,unassigned 4,3,0 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31904263&form=6&db=m Fatty acid synthase is a prognostic marker and associated with immune infiltrating in gastric cancers precision medicine. causal interaction,diagnostic usage,unassigned 3,3,0 2.3.1.39 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34456997&form=6&db=m FASN Knockdown Inhibited Anoikis Resistance of Gastric Cancer Cells via P-ERK1/2/Bcl-xL Pathway. unassigned - 2.3.1.39 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29056104&form=6&db=m A maternal high-fat, high-sucrose diet alters insulin sensitivity and expression of insulin signalling and lipid metabolism genes and proteins in male rat offspring: effect of folic acid supplementation. causal interaction,ongoing research,unassigned 1,1,0 2.3.1.39 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18682509&form=6&db=m Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers. causal interaction,unassigned 4,0 2.3.1.39 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22135723&form=6&db=m Immunohistochemical expressions of fatty acid synthase and phosphorylated c-Met in thyroid carcinomas of follicular origin. causal interaction,ongoing research,unassigned 3,2,0 2.3.1.39 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25213330&form=6&db=m Metformin-induced killing of triple-negative breast cancer cells is mediated by reduction in fatty acid synthase via miRNA-193b. unassigned - 2.3.1.39 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27106068&form=6&db=m Preclinical Evaluation of Fatty Acid Synthase and EGFR Inhibition in Triple-Negative Breast Cancer. ongoing research,unassigned 4,0 2.3.1.39 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088795&form=6&db=m Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 2.3.1.39 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29751678&form=6&db=m (-)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer. causal interaction,therapeutic application,unassigned 1,1,0 2.3.1.39 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34123778&form=6&db=m MET and FASN as Prognostic Biomarkers of Triple Negative Breast Cancer: A Systematic Evidence Landscape of Clinical Study. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.39 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34400413&form=6&db=m Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in patients with Operable TNBC. diagnostic usage,unassigned 2,0 2.3.1.39 Trophoblastic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19893031&form=6&db=m Trophoblastic neoplasms express fatty acid synthase, which may be a therapeutic target via its inhibitor C93. therapeutic application,unassigned 4,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1586161&form=6&db=m Purification and characterization of an unusually large fatty acid synthase from Mycobacterium tuberculosis var. bovis BCG. ongoing research,unassigned 4,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3880746&form=6&db=m Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guérin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA. ongoing research,unassigned 2,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8621098&form=6&db=m Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG. unassigned - 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11373295&form=6&db=m Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II. ongoing research,unassigned 1,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16112872&form=6&db=m Purification and characterization of the Mycobacterium tuberculosis FabD2, a novel malonyl-CoA:AcpM transacylase of fatty acid synthase. ongoing research,unassigned 4,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16487939&form=6&db=m Characterization and site-directed mutagenesis of the putative novel acyl carrier protein Rv0033 and Rv1344 from Mycobacterium tuberculosis. unassigned - 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16873379&form=6&db=m The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17101678&form=6&db=m Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli. ongoing research,unassigned 4,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17206854&form=6&db=m Domain analysis of fatty acid synthase protein (NP_217040) from Mycobacterium tuberculosis H37Rv--a bioinformatics study. ongoing research,unassigned 4,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17240207&form=6&db=m Rv3389C from Mycobacterium tuberculosis, a member of the (R)-specific hydratase/dehydratase family. ongoing research,therapeutic application,unassigned 1,1,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17804795&form=6&db=m The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis. ongoing research,therapeutic application,unassigned 2,1,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909282&form=6&db=m Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT). unassigned - 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18282003&form=6&db=m Modeling the Interactions of Herbal Drugs to beta-ketoacyl ACP Synthase of Mycobacterium tuberculosis H37Rv. ongoing research,therapeutic application,unassigned 2,2,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19859569&form=6&db=m Physiological Function of Mycobacterial mtFabD, an Essential Malonyl-CoA:AcpM Transacylase of Type 2 Fatty Acid Synthase FASII, in Yeast mct1Delta Cells. unassigned - 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20511508&form=6&db=m Revisiting the assignment of Rv0241c to fatty acid synthase type II of Mycobacterium tuberculosis. ongoing research,therapeutic application,unassigned 3,1,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23114755&form=6&db=m Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis. causal interaction,therapeutic application,unassigned 2,1,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23180244&form=6&db=m Rv3080c regulates the rate of inhibition of mycobacteria by isoniazid through FabD. therapeutic application,unassigned 1,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23746808&form=6&db=m Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex. causal interaction,unassigned 2,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28143508&form=6&db=m Prokaryotic ubiquitin-like protein remains intrinsically disordered when covalently attached to proteasomal target proteins. unassigned - 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30248156&form=6&db=m Expression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coli. ongoing research,therapeutic application,unassigned 3,2,0 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30250274&form=6&db=m Structure of Type-I Mycobacterium tuberculosis fatty acid synthase at 3.3?Å resolution. unassigned - 2.3.1.39 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32034201&form=6&db=m Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis. ongoing research,unassigned 3,0 2.3.1.39 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21922386&form=6&db=m Overexpression of fatty acid synthase in human urinary bladder cancer and combined expression of the synthase and Ki-67 as a predictor of prognosis of cancer patients. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0 2.3.1.39 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24815844&form=6&db=m Functional genetic variants in apoptosis-associated FAS and FASL genes and risk of bladder cancer in a Turkish population. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26718084&form=6&db=m Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho?AKT in bladder cancer. diagnostic usage,ongoing research,unassigned 1,4,0 2.3.1.39 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29567231&form=6&db=m Gallic acid inhibits bladder cancer cell proliferation and migration via regulating fatty acid synthase (FAS). causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0 2.3.1.39 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30221356&form=6&db=m Downregulation of PKM2 decreases FASN expression in bladder cancer cells through AKT/mTOR/SREBP-1c axis. causal interaction,diagnostic usage,unassigned 2,2,0 2.3.1.39 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30684846&form=6&db=m Fatty acid synthase, Her2/neu, and E2F1 as prognostic markers of progression in non-muscle invasive bladder cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0 2.3.1.39 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32239862&form=6&db=m [Effect of down-regulation of fatty acid synthase expression on proliferation, migration and invasion of bladder carcinoma UMUC3 cell lines]. causal interaction,ongoing research,unassigned 1,4,0 2.3.1.39 Usher Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33942314&form=6&db=m Cannabinoid Receptor 1 associates to different molecular complexes during GABAergic neuron maturation. unassigned - 2.3.1.39 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30237984&form=6&db=m Integrated Analysis of a Competing Endogenous RNA Network Revealing a Prognostic Signature for Cervical Cancer. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31677030&form=6&db=m SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3 2.3.1.39 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31933828&form=6&db=m CD147 promotes cervical cancer migration and invasion by up-regulating fatty acid synthase expression. causal interaction,unassigned 1,0 2.3.1.39 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24651651&form=6&db=m De novo Fatty Acid Biosynthesis Contributes Significantly to Establishment of a Bioenergetically Favorable Environment for Vaccinia Virus Infection. ongoing research,unassigned 2,0 2.3.1.39 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18830996&form=6&db=m Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production. causal interaction,unassigned 4,0 2.3.1.39 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20707918&form=6&db=m Infection with HIV and HCV enhances the release of fatty acid synthase into circulation: evidence for a novel indicator of viral infection. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0 2.3.1.39 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21199673&form=6&db=m Identification of fatty acid synthase from the Pacific white shrimp, Litopenaeus vannamei and its specific expression profiles during white spot syndrome virus infection. diagnostic usage,ongoing research,unassigned 3,3,0 2.3.1.39 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21555238&form=6&db=m Serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis. causal interaction,diagnostic usage,unassigned 4,4,0 2.3.1.39 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24696471&form=6&db=m Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 2.3.1.39 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28193229&form=6&db=m Involvement of fatty acid synthase in dengue virus infection. diagnostic usage,ongoing research,unassigned 3,4,0 2.3.1.39 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388899&form=6&db=m Metabolic profiles of fish nodavirus infection in vitro: RGNNV induced and exploited cellular fatty acid synthesis for virus infection. causal interaction,unassigned 3,0 2.3.1.39 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34132567&form=6&db=m Fatty Acid Synthase Is Involved in Classical Swine Fever Virus Replication by Interaction with NS4B. causal interaction,unassigned 1,0 2.3.1.39 Vitamin D Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31463983&form=6&db=m Vitamin D Deficiency Attenuates Acute Alcohol-Induced Hepatic Lipid Accumulation in Mice. unassigned - 2.3.1.39 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12652618&form=6&db=m Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study. causal interaction,diagnostic usage,unassigned 3,4,0 2.3.1.39 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894270&form=6&db=m Association between different levels of lipid metabolism?related enzymes and fatty acid synthase in Wilms' tumor. diagnostic usage,ongoing research,unassigned 4,2,0 2.3.1.39 [acyl-carrier-protein] s-malonyltransferase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31358769&form=6&db=m Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. causal interaction,unassigned 3,0