1.14.99.1 11beta-hydroxysteroid dehydrogenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15718388&form=6&db=m Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8601574&form=6&db=m Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8840961&form=6&db=m Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9149043&form=6&db=m Aspirin, but not sodium salicylate, indomethacin, or nabumetone, reversibly suppresses 1,2-dimethylhydrazine-induced colonic aberrant crypt foci in rats. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9439679&form=6&db=m Inhibitory effect of NS-398, a selective cyclooxygenase-2 inhibitor, on azoxymethane-induced aberrant crypt foci in colon carcinogenesis of F344 rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458081&form=6&db=m Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10893436&form=6&db=m Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats. ongoing research,unassigned 2,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11197048&form=6&db=m Non-steroidal anti-inflammatory drugs with different cyclooxygenase inhibitory profiles that prevent aberrant crypt foci formation but vary in acute gastrotoxicity in a rat model. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11216473&form=6&db=m COX-2 and iNOS, good targets for chemoprevention of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11280748&form=6&db=m Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782374&form=6&db=m Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11911260&form=6&db=m Evaluation of a selective prostaglandin E receptor EP1 antagonist for potential properties in colon carcinogenesis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12148579&form=6&db=m Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane. ongoing research,unassigned 3,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14583451&form=6&db=m Energy restriction reduces the number of advanced aberrant crypt foci and attenuates the expression of colonic transforming growth factor beta and cyclooxygenase isoforms in Zucker obese (fa/fa) rats. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14643021&form=6&db=m Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14971826&form=6&db=m Fructooligosaccharide associated with celecoxib reduces the number of aberrant crypt foci in the colon of rats. ongoing research,unassigned 3,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069535&form=6&db=m Inhibitory effects of etodolac, a selective COX-2 inhibitor, on the occurrence of tumors in colitis-induced tumorigenesis model in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15244513&form=6&db=m Indian food ingredients and cancer prevention - an experimental evaluation of anticarcinogenic effects of garlic in rat colon. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15300575&form=6&db=m Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15455344&form=6&db=m JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683997&form=6&db=m [Effects of combined use of curcumin and catechin on cyclooxygenase-2 mRNA expression in dimethylhydrazine-induced rat colon carcinogenesis] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856452&form=6&db=m A high-fat diet generates alterations in nuclear receptor expression: prevention by vitamin A and links with cyclooxygenase-2 and beta-catenin. diagnostic usage,unassigned 3,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16034162&form=6&db=m Inhibition of azoxymethane-induced aberrant crypt foci in rat by diphenylmethyl selenocyanate through downregulation of COX-2 and modulation of glutathione-S-transferase and lipid peroxidation. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16042585&form=6&db=m Is COX-2 a 'collateral' target in cancer prevention? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16101317&form=6&db=m Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16251413&form=6&db=m Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16800776&form=6&db=m Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats. causal interaction,unassigned 1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835502&form=6&db=m Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16880406&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984374&form=6&db=m Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18361741&form=6&db=m Fructooligosaccharide and soy isoflavone suppress colonic aberrant crypt foci and cyclooxygenase-2 expression in dimethylhydrazine-treated rats. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941370&form=6&db=m A 116-kDa phytoglycoprotein inhibits aberrant crypt foci formation through modulation of manganese superoxide dismutase, inducible nitric oxide synthase, cyclooxygenase-2, nuclear factor-kappa B, activator protein-1, and proliferating cell nuclear antigen in 1,2-dimethylhydrazine/dextran sodium sulfate-treated ICR mice. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268443&form=6&db=m Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20126366&form=6&db=m Dose-response assessment of the anti-cancer efficacy of soy isoflavones in dimethylhydrazine-treated rats fed 6% fructooligosaccharide. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346115&form=6&db=m Germinated brown rice (GBR) reduces the incidence of aberrant crypt foci with the involvement of beta-catenin and COX-2 in azoxymethane-induced colon cancer in rats. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20495296&form=6&db=m Coenzyme Q10 attenuated DMH-induced precancerous lesions in SD rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20511675&form=6&db=m Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20521976&form=6&db=m Suppression of colonic aberrant crypt foci by soy isoflavones is dose-independent in dimethylhydrazine-treated rats. diagnostic usage,unassigned 1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20827102&form=6&db=m Cyclooxygenase-2 is overexpressed in aberrant crypt foci of smokers. causal interaction,unassigned 3,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21554931&form=6&db=m Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats. ongoing research,unassigned 2,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21875326&form=6&db=m Light and Moderate Doses of Ethanol in Chemical Carcinogenesis of the Colon in Rats. diagnostic usage,unassigned 2,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22231745&form=6&db=m Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. therapeutic application,unassigned 1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24224098&form=6&db=m Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity of ? -Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity. therapeutic application,unassigned 1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24747869&form=6&db=m Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer. therapeutic application,unassigned 1,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25123248&form=6&db=m Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife. ongoing research,unassigned 4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26655637&form=6&db=m Anti-inflammatory and proapoptotic effects of umbelliferone in colon carcinogenesis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Aberrant Crypt Foci http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32670864&form=6&db=m Administration of Metabiotics Extracted From Probiotic Lactobacillus rhamnosus MD 14 Inhibit Experimental Colorectal Carcinogenesis by Targeting Wnt/?-Catenin Pathway. unassigned -
1.14.99.1 Abortion, Habitual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24144034&form=6&db=m Relationship between expression of COX-2, TNF-?, IL-6 and autoimmune-type recurrent miscarriage. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Abortion, Habitual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29852926&form=6&db=m Fragile X-related protein 1 (FXR1) regulates cyclooxygenase-2 (COX-2) expression at the maternal?fetal interface. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2868938&form=6&db=m Prostaglandins in the fetal circulation following maternal ingestion of a prostaglandin synthetase inhibitor during mid-pregnancy. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20819509&form=6&db=m Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22891569&form=6&db=m [Developmental toxicity of the over-the-counter analgetics and antypiretics]. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22999790&form=6&db=m Proinflammatory cytokines induced altered expression of cyclooxygenase-2 gene results in unreceptive endometrium in women with idiopathic recurrent spontaneous miscarriage. causal interaction,unassigned 2,0
1.14.99.1 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24144034&form=6&db=m Relationship between expression of COX-2, TNF-?, IL-6 and autoimmune-type recurrent miscarriage. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30420854&form=6&db=m Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31988007&form=6&db=m Does tumour necrosis factor alpha-induced cyclooxygenase-2 expression lead to spontaneous abortion in Chlamydia trachomatis-infected women. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Abortion, Spontaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34539828&form=6&db=m Benefits of ?-lipoic acid in high-risk pregnancies (Review). causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Abscess http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19726696&form=6&db=m Contribution of the prostaglandin E2/EP2 receptor-signaling pathway in abscess formation in rat zymosan-induced pleurisy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Abscess http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34251811&form=6&db=m PEP27-2, a Potent Antimicrobial Cell-Penetrating Peptide, Reduces Skin Abscess Formation during Staphylococcus aureus Infections in Mouse When Used in Combination with Antibiotics. unassigned -
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2166453&form=6&db=m Enhancement of hypoxic pulmonary vasoconstriction by metabolic acidosis in dogs. unassigned -
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2985087&form=6&db=m Inhibition by free radical scavengers and by cyclooxygenase inhibitors of the effect of acidosis on calcium transport by masseter muscle sarcoplasmic reticulum. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3375885&form=6&db=m Hyperkalemia induced by indomethacin and naproxen and reversed by fludrocortisone. causal interaction,unassigned 3,0
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8314925&form=6&db=m Indomethacin abolishes cerebral blood flow increase in response to acetazolamide-induced extracellular acidosis: a mechanism for its effect on hypercapnia? unassigned -
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8835089&form=6&db=m Cardiopulmonary effects of tumor necrosis factor-alpha in the piglet: influence of cyclooxygenase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11110772&form=6&db=m Prolonged hypercapnia-evoked cerebral hyperemia via K(+) channel- and prostaglandin E(2)-dependent endothelial nitric oxide synthase induction. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17352658&form=6&db=m Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18791491&form=6&db=m HIGH-TIDAL VOLUME VENTILATION AGGRAVATES SEPSIS-INDUCED MULTIORGAN DYSFUNCTION IN A DEXAMETHASONE-INHIBITABLE MANNER. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25461841&form=6&db=m Acidic environment activates inflammatory programs in fibroblasts via a cAMP-MAPK pathway. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26499398&form=6&db=m Acidosis differently modulates the inflammatory program in monocytes and macrophages. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31893421&form=6&db=m Extracellular Acidosis Regulates the Expression of Inflammatory Mediators in Rat Epithelial Cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Acidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34396788&form=6&db=m Metabolic acidosis regulates RGS16 and G protein signaling in osteoblasts. ongoing research,unassigned 1,0
1.14.99.1 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6419199&form=6&db=m A reexamination of the role of oxygen in retrolental fibroplasia. causal interaction,unassigned 3,0
1.14.99.1 Acidosis, Lactic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9208136&form=6&db=m Effect of calpain inhibitor I, an inhibitor of the proteolysis of I kappa B, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Acidosis, Renal Tubular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3375885&form=6&db=m Hyperkalemia induced by indomethacin and naproxen and reversed by fludrocortisone. causal interaction,unassigned 3,0
1.14.99.1 Acne Vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17642660&form=6&db=m Management of premenstrual acne with Cox-2 inhibitors: a placebo controlled study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Acne Vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20726893&form=6&db=m Induction of inflammatory reactions by lipopolysaccharide in hamster sebaceous glands and pilosebaceous units in vivo and in vitro. causal interaction,unassigned 3,0
1.14.99.1 Acne Vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28025036&form=6&db=m Decreased eicosapentaenoic acid levels in acne vulgaris reveals the presence of a proinflammatory state. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,3
1.14.99.1 Acne Vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207817&form=6&db=m Immunohistochemical Expression of Cyclo-oxygenase 2 and Liver X Receptor-? in Acne Vulgaris. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Acne Vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152431&form=6&db=m Saponin fraction from Sapindus mukorossi Gaertn as a novel cosmetic additive: Extraction, biological evaluation, analysis of anti-acne mechanism and toxicity prediction. therapeutic application,unassigned 4,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1660487&form=6&db=m Cyclooxygenase and lipoxygenase arachidonic acid metabolism by monocytes from human immune deficiency virus-infected drug users. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108735&form=6&db=m Cyclooxygenase inhibition and improved oxygenation in patients with pulmonary complications of AIDS. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6333432&form=6&db=m Indomethacin enhances the proliferation of mitogen-stimulated T lymphocytes of homosexual males with persistent generalized lymphadenopathy. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11679155&form=6&db=m Essential role of HIV type 1-infected and cyclooxygenase 2-activated macrophages and T cells in HIV type 1 myocarditis. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15750045&form=6&db=m Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury. causal interaction,unassigned 3,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16001969&form=6&db=m Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17017944&form=6&db=m Anti-inflammatory drugs in the treatment of neurodegenerative diseases: current state. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22157616&form=6&db=m Lentiviral infection of rhesus macaques causes long-term injury to cortical and hippocampal projections of prostaglandin-expressing cholinergic basal forebrain neurons. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27629384&form=6&db=m Combined Variants in Factor VIII and Prostaglandin Synthase-1 Amplify Hemorrhage Severity Across Three Generations of Descendants. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31364378&form=6&db=m Cellular cholesterol modifies flow-mediated gene expression. causal interaction,unassigned 2,0
1.14.99.1 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32396751&form=6&db=m Pharmacological and non-pharmacological pain relief for office hysteroscopy: an up-to-date review. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Acromegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171274&form=6&db=m Cyclooxygenase enzyme and PGE2 expression in patients with functional and non-functional pituitary adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9860792&form=6&db=m Platelet-derived 12-hydroxyeicosatetraenoic acid plays an important role in mediating canine coronary thrombosis by regulating platelet glycoprotein IIb/IIIa activation. unassigned -
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9890391&form=6&db=m A randomized, placebo-controlled, crossover study of E5510 and aspirin in healthy volunteers. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12105157&form=6&db=m Efficacy assessment of meloxicam, a preferential cyclooxygenase-2 inhibitor, in acute coronary syndromes without ST-segment elevation: the Nonsteroidal Anti-Inflammatory Drugs in Unstable Angina Treatment-2 (NUT-2) pilot study. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12549993&form=6&db=m [Role of anti-inflammatory drugs in the treatment of acute coronary syndromes. From athero-inflammation to athero-thrombosis] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,4
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576372&form=6&db=m Cyclooxygenase-2 inhibitors: are they really atherothrombotic, and if not, why not? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14592854&form=6&db=m Cyclooxygenase-2 expression and inhibition in atherothrombosis. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15136366&form=6&db=m Rofecoxib, a COX-2 inhibitor, lowers C-reactive protein and interleukin-6 levels in patients with acute coronary syndromes. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15283037&form=6&db=m [Specific cyclo-oxygenase-2 inhibitors in cardiovascular pathology] causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383474&form=6&db=m Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16102103&form=6&db=m Novel determinants of plaque instability. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16190383&form=6&db=m [Significance and expression of cyclooxygenase-2 mRNA in peripheral blood monocytes in patients with acute coronary syndrome] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16330117&form=6&db=m Divergent effects of rofecoxib on endothelial function and inflammation in acute coronary syndromes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16934052&form=6&db=m Cyclooxygenase-2 inhibitors and coronary occlusion--exploring dose-response relationships. therapeutic application,unassigned 4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18989535&form=6&db=m Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19076093&form=6&db=m [Protective effect of lornoxicam on development of myocardial infarction in rats under conditions of ischemia and ischemia-reperfusion] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148793&form=6&db=m Prevention of nonsteroidal anti-inflammatory drug-induced gastropathy. unassigned -
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19485927&form=6&db=m Genetic and Molecular Determinants of Atherosclerotic Plaque Instability. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19578513&form=6&db=m Biomarkers and Bioassays for Cardiovascular Diseases: Present and Future. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19741338&form=6&db=m Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in humans. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19748095&form=6&db=m Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19781342&form=6&db=m [Expression of COX-2 and pregnancy associate plasma protein A in coronary arteries and their relationship with acute coronary syndrome: an autopsy study of 42 cases] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21241965&form=6&db=m Effects of short-term anti-inflammatory therapy on endothelial function in patients with non-ST-segment elevation acute coronary syndrome. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21371074&form=6&db=m The risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors does not vary with polymorphisms in two regions of the cyclo-oxygenase-2 gene. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21427504&form=6&db=m Role of Platelets and Antiplatelet Therapy in Cardiovascular Disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25066685&form=6&db=m Greater collagen-induced platelet aggregation following cyclooxygenase 1 inhibition predicts incident acute coronary syndromes. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,3,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26559689&form=6&db=m Vorapaxar in the secondary prevention of atherothrombosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30654930&form=6&db=m Meta-Analysis of the Role of Cangrelor for Patients Undergoing Percutaneous Coronary Intervention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Acute Coronary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31828756&form=6&db=m Assessment of platelet function after discontinuation of ticagrelor. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316248&form=6&db=m Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid. causal interaction,unassigned 3,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11945151&form=6&db=m Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12093311&form=6&db=m Renal failure associated with the use of celecoxib and rofecoxib. unassigned -
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12389882&form=6&db=m Cyclooxygenase-2 inhibitor-associated acute renal failure: case report with rofecoxib and review of the literature. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12455713&form=6&db=m Do non-steroidal anti-inflammatory drugs and COX-2 selective inhibitors have different renal effects? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14579947&form=6&db=m Acute renal failure after administration of a single dose of a highly selective COX-2 inhibitor. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691350&form=6&db=m Renal cyclooxygenase-2 (COX-2). Physiological, pathophysiological, and clinical implications. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14993496&form=6&db=m Acute renal failure and hyperkalaemia associated with cyclooxygenase-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15786824&form=6&db=m COX-2 inhibitor induced anuric renal failure in a previously healthy young woman. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15957551&form=6&db=m Nephrotoxicity related to new therapeutic compounds. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16955281&form=6&db=m Nephrotoxicity with cyclooxygenase 2 inhibitor use in children. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17005625&form=6&db=m Association of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure: A population-based, nested case-control analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652370&form=6&db=m Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice. ongoing research,unassigned 3,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17965845&form=6&db=m [Medication-induced impairment of renal function: what is important?] unassigned -
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18946499&form=6&db=m COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex. therapeutic application,unassigned 1,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19028206&form=6&db=m Nonselective and cyclooxygenase-2-selective NSAIDs and acute kidney injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19711010&form=6&db=m Modulation of inflammatory response by selective inhibition of cyclooxygenase-1 and cyclooxygenase-2 in acute kidney injury. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22129825&form=6&db=m Profound urinary protein loss and acute renal failure caused by cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22258319&form=6&db=m Inhibition of glycogen synthase kinase-3? prevents NSAID-induced acute kidney injury. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22688984&form=6&db=m Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure. diagnostic usage,unassigned 3,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26945352&form=6&db=m Adverse Effects of Oral Nonselective and cyclooxygenase-2-Selective NSAIDs on Hospitalization for Acute Kidney Injury: A Nested Case-Control Cohort Study. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27853386&form=6&db=m Selective cyclooxygenase-2 inhibitor use and progression of renal function in patients with chronic kidney disease: a single-center retrospective cohort study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28614595&form=6&db=m Perioperative COX-2 inhibitors may increase the risk of post-operative acute kidney injury. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849533&form=6&db=m Protective Effect of Taurine on Mice with Doxorubicin-induced Acute Kidney Injury. ongoing research,unassigned 2,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30413885&form=6&db=m Endothelial prostacyclin protects the kidney from ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30870859&form=6&db=m Effect of Caffeic Acid on Ischemia-Reperfusion-Induced Acute Renal Failure in Rats. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Acute Kidney Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33975771&form=6&db=m Thalidomide reduces glycerol-induced acute kidney injury by inhibition of NF-?B, NLRP3 inflammasome, COX-2 and inflammatory cytokines. therapeutic application,unassigned 2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1320299&form=6&db=m The neutrophil respiratory burst and tissue injury in septic acute lung injury: the effect of cyclooxygenase inhibition in swine. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1474095&form=6&db=m Enhanced microvascular permeability of PMA-induced acute lung injury is not mediated by cyclooxygenase products. causal interaction,unassigned 4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1568970&form=6&db=m Ibuprofen reduces ethchlorvynol lung injury: possible role of blood flow distribution. causal interaction,unassigned 2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1917763&form=6&db=m Cyclooxygenase inhibitors prevent ethchlorvynol-induced injury in rat and rabbit lungs. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1939868&form=6&db=m The pulmonary circulation in acute lung injury: a review of some recent advances. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124586&form=6&db=m Cyclooxygenase inhibition prevents PMA-induced increases in lung vascular permeability. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3093450&form=6&db=m Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115948&form=6&db=m Bronchial circulation and cyclooxygenase products in acute lung injury. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3985125&form=6&db=m Mediators of lung injury in mice following systemic activation of complement. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8002544&form=6&db=m Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8041036&form=6&db=m [Effects of vasoactive cyclooxygenase products on shunt flow and extravascular lung water in acute lung injuries] ongoing research,unassigned 3,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8112447&form=6&db=m Medical treatment of pulmonary hypertension in acute lung disease. causal interaction,unassigned 1,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8964757&form=6&db=m Effect of eicosanoid inhibition on the development of pulmonary edema after acute lung injury. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10508803&form=6&db=m Role of cyclooxygenase-2 in oleic acid-induced acute lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10749804&form=6&db=m Prostaglandins potentiate U-46619-induced pulmonary microvascular dysfunction. causal interaction,unassigned 4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11373473&form=6&db=m Influence of cyclooxygenase and lipoxygenase inhibitors on oxidative stress-induced lung injury. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11775825&form=6&db=m [The effect of cyclooxygenase-2 inhibitor on acute lung injury] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12134647&form=6&db=m [Prostanoids and acute lung injury] ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15551400&form=6&db=m Components of diesel exhaust particles differentially affect lung expression of cyclooxygenase-2 related to bacterial endotoxin. causal interaction,unassigned 3,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15612612&form=6&db=m Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15814734&form=6&db=m Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. causal interaction,unassigned 4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16443000&form=6&db=m Meta-analysis: Methods, strengths, weaknesses, and political uses. therapeutic application,unassigned 4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16565483&form=6&db=m Lipoxin A(4) regulates bronchial epithelial cell responses to acid injury. causal interaction,unassigned 2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493609&form=6&db=m Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. causal interaction,unassigned 3,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18318262&form=6&db=m [Cyclooxygenase 2 derived lipid mediators play a pivotal role in resolution of acute lung injury] causal interaction,unassigned 4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18404075&form=6&db=m Cyclooxygenase-2 suppresses polymorphonuclear neutrophil apoptosis after acute lung injury. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19567182&form=6&db=m [The effect of nitric oxide inhalation on the expression of COX-2 and toll-like receptor 4 in rat acute lung injury induced by lipopolysaccharide] ongoing research,unassigned 4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20926798&form=6&db=m Substance P Upregulates Cyclooxygenase-2 and Prostaglandin E Metabolite by Activating ERK1/2 and NF-{kappa}B in a Mouse Model of Burn-Induced Remote Acute Lung Injury. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21074783&form=6&db=m Glycyrrhizin treatment is associated with attenuation of lipopolysaccharide-induced acute lung injury by inhibiting cyclooxygenase-2 and inducible nitric oxide synthase expression. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957141&form=6&db=m Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22556158&form=6&db=m The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23158409&form=6&db=m Shikonin attenuates lipopolysaccharide-induced acute lung injury in mice. therapeutic application,unassigned 4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23688977&form=6&db=m [Protective mechanisms of sevoflurane against one-lung ventilation-induced acute lung injury: role of cyclooxygenase-2 and 5-lipoxygenase pathways]. therapeutic application,unassigned 1,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24958013&form=6&db=m Anti-Inflammatory Effects of Apigenin in Lipopolysaccharide-Induced Inflammatory in Acute Lung Injury by Suppressing COX-2 and NF-kB Pathway. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25660288&form=6&db=m Ginkgo biloba extracts attenuate lipopolysaccharide-induced inflammatory responses in acute lung injury by inhibiting the COX-2 and NF-?B pathways. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26276127&form=6&db=m Protective Effect of Isorhamnetin on Lipopolysaccharide-Induced Acute Lung Injury in Mice. ongoing research,unassigned 4,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26880863&form=6&db=m Matrine Attenuates COX-2 and ICAM-1 Expressions in Human Lung Epithelial Cells and Prevents Acute Lung Injury in LPS-Induced Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Acute Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27104958&form=6&db=m Dexamethasone Attenuates LPS-induced Acute Lung Injury through Inhibition of NF-?B, COX-2, and Pro-inflammatory Mediators. causal interaction,unassigned 2,0
1.14.99.1 Acute-On-Chronic Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22152242&form=6&db=m [Expression of COX-2 and PPARr in the livers of patients with acute on chronic HBV-related liver failure and their relationship with clinic parameters]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3090559&form=6&db=m Antitumor activity in a rat mammary adenocarcinoma: the effect of cyclooxygenase inhibitors and immunization against prostaglandin E2. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3409218&form=6&db=m Profiles of prostaglandin biosynthesis in sixteen established cell lines derived from human lung, colon, prostate, and ovarian tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3937158&form=6&db=m Antitumor activity in a rat mammary adenocarcinoma: the effect of cyclooxygenase inhibitors and immunization against prostaglandin E2. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6393859&form=6&db=m The effect of prostaglandin modulators on prostate tumor growth and metastasis. therapeutic application,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6409616&form=6&db=m Prostaglandin concentrations and prostaglandin synthetase activity in N-nitrosomethylurea-induced rat mammary adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7926468&form=6&db=m Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8566864&form=6&db=m Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631005&form=6&db=m G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. causal interaction,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8960892&form=6&db=m Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9102213&form=6&db=m Expression of cyclooxygenase-2 in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9160111&form=6&db=m Colorectal cancer and nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9344613&form=6&db=m Prostaglandin H synthase expression is variable in human colorectal adenocarcinoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9405496&form=6&db=m Expression of prostaglandin G/H synthase type 1, but not type 2, in human ovarian adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9442092&form=6&db=m Dihydroxy bile acids activate the transcription of cyclooxygenase-2. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679948&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9703885&form=6&db=m Cyclooxygenase-2 expression in human adenocarcinoma cell line HT29 cl.19A. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731479&form=6&db=m Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9804170&form=6&db=m Cyclooxygenase-2 up-regulation after FLAP transfection in human adenocarcinoma cell line HT29 cl.19A. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823297&form=6&db=m Expression of cyclooxygenase-2 in human lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846504&form=6&db=m Expression of cyclooxygenase-2 protein in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9858942&form=6&db=m Resistance to apoptosis and cyclooxygenase-2 expression in a human adenocarcinoma cell line HT29 CL.19A. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872498&form=6&db=m Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892207&form=6&db=m Cyclooxygenase-2 expression in human esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10069452&form=6&db=m Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10070951&form=6&db=m Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10197601&form=6&db=m Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet. causal interaction,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353732&form=6&db=m Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10425287&form=6&db=m Expression of cyclooxygenase-2 in human adenocarcinomas of the gastric cardia and corpus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10445576&form=6&db=m Cyclooxygenase-2 in Barrett's esophagus, Barrett's adenocarcinomas, and esophageal SCC: ready for clinical trials. therapeutic application,unassigned 1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10451445&form=6&db=m Induction of prostaglandin G/H synthase-2 in a canine model of spontaneous prostatic adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10471521&form=6&db=m Coordinate up-regulation of low-density lipoprotein receptor and cyclo-oxygenase-2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485483&form=6&db=m Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515422&form=6&db=m Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10579801&form=6&db=m Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597402&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10628596&form=6&db=m General tolerability and use of nonsteroidal anti-inflammatory drugs. causal interaction,unassigned 1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630643&form=6&db=m The role of cyclooxygenases in inflammation, cancer, and development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10645245&form=6&db=m Mitogen-activated protein kinase activation and regulation of cyclooxygenase 2 expression by platelet-activating factor and hCG in human endometrial adenocarcinoma cell line HEC-1B. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10656441&form=6&db=m Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657949&form=6&db=m Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10665651&form=6&db=m Cyclooxygenase-2 (COX-2) mRNA expression levels in normal lung tissues and non-small cell lung cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668484&form=6&db=m The role of COX-2 in intestinal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10695990&form=6&db=m Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10697514&form=6&db=m Comparative ability of ibuprofen and N-(4-hydroxyphenyl)retinamide to inhibit development of rat mammary adenocarcinomas associated with differential inhibition of gene expression of cyclooxygenase isoforms. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10702199&form=6&db=m Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10815926&form=6&db=m Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861458&form=6&db=m Effect of the specific cyclooxygenase-2 inhibitor meloxicam on tumour growth and cachexia in a murine model. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874009&form=6&db=m Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874016&form=6&db=m Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10952941&form=6&db=m Expression of cyclooxygenase 2 by prostaglandin E(2) in human endometrial adenocarcinoma cell line HEC-1B. ongoing research,unassigned 3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953290&form=6&db=m Immunohistochemical study of cyclooxygenases in prostatic adenocarcinoma; relationship to apoptosis and Bcl-2 protein expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980112&form=6&db=m Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980113&form=6&db=m The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005569&form=6&db=m Indomethacin-induced apoptosis in esophageal adenocarcinoma cells involves upregulation of Bax and translocation of mitochondrial cytochrome C independent of COX-2 expression. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059772&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11086200&form=6&db=m Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11172698&form=6&db=m Gastroesophageal reflux disease (GERD): current agents and future perspective. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11176123&form=6&db=m Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11180079&form=6&db=m Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223821&form=6&db=m Expression of cyclooxygenase-2 in human gastric adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11228540&form=6&db=m Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11241241&form=6&db=m Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278747&form=6&db=m Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310211&form=6&db=m Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316217&form=6&db=m Cyclooxygenase-2 expression in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11344234&form=6&db=m Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11396201&form=6&db=m Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448905&form=6&db=m Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11494020&form=6&db=m Co-expression of beta-adrenergic receptors and cyclooxygenase-2 in pulmonary adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11504793&form=6&db=m Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566494&form=6&db=m Expression of nitric oxide synthase, cyclooxygenase, and p53 in different stages of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11586094&form=6&db=m Expression of inflammatory modulator COX-2 in pancreatic ductal adenocarcinoma and its relationship to pathologic and clinical parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592775&form=6&db=m Expression of COX-2 and PGE synthase and synthesis of PGE(2)in endometrial adenocarcinoma: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. causal interaction,diagnostic usage,unassigned 2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605016&form=6&db=m Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11731423&form=6&db=m Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11783060&form=6&db=m [A study on cyclooxygenase-2 protein expression in esophageal carcinoma and premalignant lesions] causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11793368&form=6&db=m Cyclooxygenase-2 expression during carcinogenesis in the human stomach. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809691&form=6&db=m Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809702&form=6&db=m Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11851614&form=6&db=m Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861541&form=6&db=m Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11897504&form=6&db=m Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11904306&form=6&db=m Cyclooxygenase-2 inhibitor therapy for the prevention of esophageal adenocarcinoma in Barrett's esophagus. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11910360&form=6&db=m Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920515&form=6&db=m Immunohistochemical analysis and in situ hybridization of cyclooxygenase-2 expression in intraductal papillary-mucinous tumors of the pancreas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011984&form=6&db=m Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12051958&form=6&db=m PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12055587&form=6&db=m Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060038&form=6&db=m Angiogenic markers, neovascularization and malignant deformation of Barrett's esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066205&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086398&form=6&db=m Oxidant-sensitive transcription factor and cyclooxygenase-2 by Helicobacter pylori stimulation in human gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086404&form=6&db=m Increased expression of COX-2 in the development of human lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12105834&form=6&db=m Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126145&form=6&db=m Cyclooxygenase-2 expression in spontaneous intestinal neoplasia of domestic dogs. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12162677&form=6&db=m Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia: an immunohistochemical analysis with automated cellular imaging. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196918&form=6&db=m Expression of apoptosis-related proteins in Barrett's metaplasia-dysplasia-carcinoma sequence: a switch to a more resistant phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12269772&form=6&db=m Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434411&form=6&db=m Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452063&form=6&db=m [Influence of selective cyclooxygenase-2 inhibitor on proliferation of human gastric cancer cells] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468638&form=6&db=m Seminal plasma activates cyclooxygenase-2 and prostaglandin E2 receptor expression and signalling in cervical adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12469191&form=6&db=m Expression of cyclooxygenase-2 and its relationship to p53 accumulation in ovarian adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504222&form=6&db=m Selective cyclooxygenase-2 inhibitor rofecoxib (Vioxx) induces expression of cell cycle arrest genes and slows tumor growth in human pancreatic cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12512030&form=6&db=m Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523498&form=6&db=m The expression of cyclooxygenase-1 and -2 in proliferative endometrium and endometrial adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12532441&form=6&db=m Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12553373&form=6&db=m Effects of Celebrex and Zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in Syrian hamsters. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12578839&form=6&db=m Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591965&form=6&db=m COX-2, inflammatory secreted PLA2, and cytoplasmic PLA2 protein expression in small bowel adenocarcinomas compared with colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12618325&form=6&db=m Cyclooxygenase-2 and prostate carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626523&form=6&db=m Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12633561&form=6&db=m Cyclooxygenase-2 in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637762&form=6&db=m Cyclooxygenase-2 expression in canine mammary tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648590&form=6&db=m High cyclooxygenase-2 expression in cervical adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679908&form=6&db=m Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686777&form=6&db=m Expression of COX-2 in stomach cancers and its relation to their biological features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713622&form=6&db=m Cyclooxygenase-2 is expressed frequently and early in Barrett's oesophagus and associated adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12717830&form=6&db=m Nimesulide inhibits proliferation via induction of apoptosis and cell cycle arrest in human gastric adenocarcinoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738712&form=6&db=m Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12748469&form=6&db=m Expression of cyclooxygenase-2 in cervical, endometrial, and ovarian malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12781040&form=6&db=m Effects of combined octreotide and aspirin on the growth of gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810622&form=6&db=m Cyclooxygenase-2 expression and effect of celecoxib in gastric adenomas of trefoil factor 1-deficient mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12837940&form=6&db=m Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12855643&form=6&db=m Correlation between cyclooxygenase-2 expression and angiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12893070&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in premalignant and malignant esophageal glandular and squamous lesions in Cixian, China. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895344&form=6&db=m [Overexpression of COX-2 and its clinical significance in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12910695&form=6&db=m [The effects of selective cyclooxygenase-2 inhibitors on the growth of gastric adenocarcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949405&form=6&db=m An immunohistochemical study of cyclooxygenase-2 expression in various feline neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532848&form=6&db=m Cyclooxygenase-2 inhibitor NS398 enhances antitumor effect of irradiation on hormone refractory human prostate carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532998&form=6&db=m Overexpression of cyclooxygenase-2 protein and its relationship to apoptosis in cervical carcinoma treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552327&form=6&db=m COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14598890&form=6&db=m Suppression by nimesulide of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14616542&form=6&db=m Cyclooxygenase-2 and gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14629099&form=6&db=m Barrett's esophagus: chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633942&form=6&db=m Comparison of cyclooxygenase 2 expression in adenocarcinomas of the gastric cardia and distal oesophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14641306&form=6&db=m Chemoprevention for Barrett's esophagus trial. Design and outcome measures. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14656949&form=6&db=m Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14743889&form=6&db=m Role of cyclooxygenase-2 in the development and treatment of oesophageal adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14750244&form=6&db=m COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung. A study of 117 patients from Brazil. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760075&form=6&db=m Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14967078&form=6&db=m Cyclooxygenase-2 inhibitors in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14977856&form=6&db=m Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator- activated receptor-gamma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981968&form=6&db=m Expression of cyclooxygenase-2, Fas and Fas ligand in pulmonary adenocarcinoma and atypical adenomatous hyperplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999227&form=6&db=m A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15027493&form=6&db=m Cyclooxygenase 2: from inflammation to carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15033780&form=6&db=m CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15068324&form=6&db=m HER-2, EGFR, COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15094711&form=6&db=m Phenotype of columnar-lined esophagus in rats with esophagogastroduodenal anastomosis: similarity to human Barrett's esophagus. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15112579&form=6&db=m Nuclear factor-kappa B regulates cyclooxygenase-2 expression and cell proliferation in human colorectal carcinoma tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15116331&form=6&db=m Cyclooxygenase-2 expression correlates with angiogenesis and apoptosis in gastric cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15126378&form=6&db=m Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145696&form=6&db=m Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15155531&form=6&db=m Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15165031&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179623&form=6&db=m COX-2 inhibition and lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197770&form=6&db=m Suppression of cyclooxygenase-2 overexpression by 15S-hydroxyeicosatrienoic acid in androgen-dependent prostatic adenocarcinoma cells. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15221998&form=6&db=m Pilot study of celecoxib and infusional 5-fluorouracil as second-line treatment for advanced pancreatic carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222037&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15230726&form=6&db=m Cyclo-oxygenase-2 expression in esophageal adenocarcinoma as a determinant of clinical outcome following esophagectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231484&form=6&db=m Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15246187&form=6&db=m Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15269153&form=6&db=m Gastrin-induced cyclooxygenase-2 expression in Barrett's carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15283156&form=6&db=m [Overexpression of COX-2 and a potential clinical application of its inhibitors in lung cancer] causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313405&form=6&db=m Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355919&form=6&db=m Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15382074&form=6&db=m Enhanced inhibitive effects of combination of rofecoxib and octreotide on the growth of human gastric cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383758&form=6&db=m Acid suppression and chemoprevention in Barrett's oesophagus. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15387324&form=6&db=m Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15455344&form=6&db=m JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15459021&form=6&db=m Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxygenase-2 and inducible nitric oxide synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465199&form=6&db=m Differential cyclooxygenase-2 expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15472909&form=6&db=m Selective inhibition of cyclooxygenase (COX)-2 inhibits endothelial cell proliferation by induction of cell cycle arrest. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475461&form=6&db=m Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475936&form=6&db=m Cytoplasmic phospholipase A2 alpha overexpression in stromal cells is correlated with angiogenesis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15477758&form=6&db=m Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15562904&form=6&db=m Elevated expression of cyclooxygenase-2 in adenocarcinoma of the parotid gland: insights into malignant transformation of pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15581957&form=6&db=m Expression of cyclooxygenase-2 in adenocarcinomas of the uterine cervix and its relation to angiogenesis and tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585388&form=6&db=m Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15587390&form=6&db=m Expression and significance of cyclooxygenase 2 gene in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623626&form=6&db=m Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623628&form=6&db=m Loss of heterozygosity and immunohistochemistry of adenocarcinomas of the esophagus and gastric cardia. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15703582&form=6&db=m Barrett esophagus. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15704107&form=6&db=m Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710986&form=6&db=m Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716238&form=6&db=m Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723653&form=6&db=m Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754411&form=6&db=m Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15789623&form=6&db=m A phase I study of 5-fluorouracil, leucovorin, and celecoxib in patients with incurable colorectal cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816542&form=6&db=m Growth inhibitory effect of celecoxib and rofecoxib on human colorectal carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856454&form=6&db=m Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863127&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870720&form=6&db=m Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15921850&form=6&db=m Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15958546&form=6&db=m Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15978332&form=6&db=m Prognostic role of cyclooxygenase-2 expression in esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15979837&form=6&db=m COX2 expression, angiogenesis, proliferation and survival in Barrett's cancer. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15991524&form=6&db=m Expression of cyclooxygenase-2 in endometrial adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15992053&form=6&db=m The role of COX-2 in intestinal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16034525&form=6&db=m A phase II study of celecoxib, gemcitabine, and cisplatin in advanced pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081631&form=6&db=m A positive feedback loop that regulates cyclooxygenase-2 expression and prostaglandin F2alpha synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083499&form=6&db=m Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111045&form=6&db=m [Role of cyclooxygenase-2 in inhibition of human gastric adenocarcinoma cell line SGC-7901 by c9, t11-conjugated linoleic acid] ongoing research,unassigned 2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111807&form=6&db=m Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16143029&form=6&db=m Cyclooxygenase-2 expression and cell proliferation are increased in MUC2-positive area of columnar-lined esophagus. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16175586&form=6&db=m Adenocarcina of the mouse prostate growth inhibition by celecoxib: downregulation of transcription factors involved in COX-2 inhibition. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16215757&form=6&db=m PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16216410&form=6&db=m Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243808&form=6&db=m Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16246405&form=6&db=m Prevalence and prognostic significance of COX-2 expression in stage IB cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16266236&form=6&db=m Cyclooxygenase-2 inhibition in colon experimental carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299956&form=6&db=m [Prognostic significance of cyclooxygenase 2 expression in adenocarcinoma of the esophagus] causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16301573&form=6&db=m Cyclooxygenase-2 expression is associated with histologic tumor type in canine mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16327494&form=6&db=m Neoadjuvant selective COX-2 inhibition down-regulates important oncogenic pathways in patients with esophageal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16395701&form=6&db=m Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16426169&form=6&db=m Resection and use of a cyclooxygenase-2 inhibitor for treatment of pancreatic adenocarcinoma in a cockatiel. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16467169&form=6&db=m Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474375&form=6&db=m Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474989&form=6&db=m Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16482563&form=6&db=m Polymorphisms in the genes involved in the arachidonic acid-pathway, fish consumption and the risk of colorectal cancer. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507392&form=6&db=m Curcumin synergistically potentiates the growth inhibitory and pro-apoptotic effects of celecoxib in pancreatic adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16521222&form=6&db=m Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16542464&form=6&db=m Relationship between cyclooxygenase 8473T>C polymorphism and risk of lung cancer: a case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550596&form=6&db=m Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16573762&form=6&db=m Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16596993&form=6&db=m Chemopreventive effect of protein extract of Asterina pectinifera in HT-29 human colon adenocarcinoma cells. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16615003&form=6&db=m Effects of cyclooxygenase-2 inhibition on serum and tumor gastrins and expression of apoptosis-related proteins in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16681759&form=6&db=m Increased cyclooxygenase-2 expression is correlated with suppressed antitumor immunity in cervical adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16682957&form=6&db=m Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16702519&form=6&db=m Molecular determinants in targeted therapy for esophageal adenocarcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712734&form=6&db=m Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16733863&form=6&db=m Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16737669&form=6&db=m Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16786043&form=6&db=m Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16799479&form=6&db=m Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820089&form=6&db=m Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899364&form=6&db=m Role of prostaglandin E2 in the invasiveness, growth and protection of cancer cells in malignant pleuritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900533&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996907&form=6&db=m Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17003101&form=6&db=m Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17006983&form=6&db=m -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17022010&form=6&db=m Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030351&form=6&db=m COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17031101&form=6&db=m Gastroesophageal reflux disease. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049779&form=6&db=m Increased expression of cyclooxygenase-2 and Ki-67 are associated with malignant transformation of pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17121089&form=6&db=m Cyclooxygenase-2 expression in feline pancreatic adenocarcinomas. unassigned -
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201164&form=6&db=m Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17213037&form=6&db=m Immunohistochemical expression of p53, Bcl-2, COX-2, C-erb-B2, EPO-R, beta-catenin, and E-cadherin in non tumoral gastric mucous membrane. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220580&form=6&db=m Cyclo-oxygenase-2 over-expression is associated with human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244951&form=6&db=m NO-releasing aspirin exerts stronger growth inhibitory effect on Barrett's adenocarcinoma cells than traditional aspirin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17307036&form=6&db=m COX-2, CDX2, and CDC2 immunohistochemical assessment for dysplasia-carcinoma progression in Barrett's esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17354612&form=6&db=m Cyclooxygenase-2 (COX-2) expression in human endometrial carcinoma and precursor lesions and its possible use in cancer chemoprevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17357536&form=6&db=m Tissue microarray-determined expression profiles of cyclooxygenase-2 in colorectal adenocarcinoma: association with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403674&form=6&db=m NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett's esophageal adenocarcinoma cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437847&form=6&db=m Increased expression of cyclooxygenase-2 correlates with resistance to radiation in human prostate adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17462298&form=6&db=m The risks and benefits of cyclo-oxygenase-2 inhibitors in prostate cancer: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17477358&form=6&db=m Selective cyclooxygenase-2 inhibition suppresses basic fibroblast growth factor expression in human esophageal adenocarcinoma. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17478553&form=6&db=m F-prostanoid receptor regulation of fibroblast growth factor 2 signaling in endometrial adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17553653&form=6&db=m Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581270&form=6&db=m COX-2 CA-Haplotype Is a Risk Factor for the Development of Esophageal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581404&form=6&db=m Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584489&form=6&db=m Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17604323&form=6&db=m COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma. causal interaction,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653443&form=6&db=m Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17675820&form=6&db=m [Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide] causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17691999&form=6&db=m Prevention of cancer in the upper gastrointestinal tract with COX-inhibition. Still an option? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17707579&form=6&db=m Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17762961&form=6&db=m 5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17763959&form=6&db=m Effect of adiponectin and ghrelin on apoptosis of Barrett adenocarcinoma cell line. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17887937&form=6&db=m A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17901590&form=6&db=m Inhibition of Barret's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins. unassigned -
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17942462&form=6&db=m The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18000398&form=6&db=m Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18027868&form=6&db=m CS-706, a novel cyclooxygenase-2 selective inhibitor, prolonged the survival of tumor-bearing mice when treated alone or in combination with anti-tumor chemotherapeutic agents. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18075199&form=6&db=m Spontaneous adenocarcinoma immunoreactive to cyclooxygenase-2 and transforming growth factor-beta1 in the buccal salivary gland of a Richardson's ground squirrel (Spermophilus richardsonii). unassigned -
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094611&form=6&db=m Increased expression of cytoplasmic HuR in familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159596&form=6&db=m Sulindac prevents esophageal adenocarcinomas induced by gastroduodenal reflux in rats. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18186150&form=6&db=m COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18214062&form=6&db=m hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230181&form=6&db=m Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18287870&form=6&db=m From endometrial hyperplasia to endometrial cancer: insight into the biology and possible medical preventive measures. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18316157&form=6&db=m Prostaglandin E(2) and F(2alpha) activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18330937&form=6&db=m Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: A study from northern India. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18349295&form=6&db=m Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Gene Polymorphisms and Risk of Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18349821&form=6&db=m Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18416056&form=6&db=m [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18443952&form=6&db=m Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18453539&form=6&db=m COX-2/EGFR expression and survival among women with adenocarcinoma of the lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18507031&form=6&db=m Prognostic value of eicosanoid pathways in extrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617777&form=6&db=m Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18618313&form=6&db=m Lactobacillus acidophilus 74-2 and butyrate induce cyclooxygenase (COX)-1 expression in gastric cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676768&form=6&db=m Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18683800&form=6&db=m [The effect of siRNA on inhibiting cyclooxygenase-2 gene expression in gastric adenocarcinoma cell] causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18783518&form=6&db=m Helicobacter pylori and non-malignant diseases. therapeutic application,unassigned 1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18942401&form=6&db=m [Immunohistochemical markers as prognosticators in gynecologic oncology] causal interaction,diagnostic usage,unassigned 2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19058955&form=6&db=m Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107602&form=6&db=m Expression of COX-2 in Stomach Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109152&form=6&db=m Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208339&form=6&db=m The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232171&form=6&db=m [The immunohistochemical expression of cyclooxygenase 2 is inversely associated with (18)F-FDG-PET SUV values in non-small-cell lung cancers. Initial results] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19346994&form=6&db=m Clinicopathological Correlations of Cyclooxygenase-2, MDM2, and p53 Expressions in Surgically Resectable Pancreatic Invasive Ductal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19513556&form=6&db=m Nicotinamide phosphoribosyltransferase and prostaglandin H2 synthase 2 are up-regulated in human pancreatic adenocarcinoma cells after stimulation with interleukin-1. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19534809&form=6&db=m Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19596931&form=6&db=m Discrepancies in expression and prognostic value of tumor markers in adenocarcinoma and squamous cell carcinoma in cervical cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19639178&form=6&db=m Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19729335&form=6&db=m Malignant salivary gland tumors and cyclo-oxygenase-2: A histopathological and immunohistochemical analysis with implications on histogenesis. ongoing research,unassigned 3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19758455&form=6&db=m Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19830863&form=6&db=m [Chemoprevention of Barrett's esophagus by celecoxib in rats.] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19836124&form=6&db=m Prevalence and clinical relevance of cyclooxygenase-1 and -2 expression in stage IIB cervical adenocarcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843025&form=6&db=m Prostaglandin EP2 receptor expression is increased in Barrett's esophagus and esophageal adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19891691&form=6&db=m Treatment of feline mammary tumours using chemotherapy, surgery and a COX-2 inhibitor drug (meloxicam): a retrospective study of 23 cases (2002-2007)*. therapeutic application,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925030&form=6&db=m Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20017300&form=6&db=m [Construction of recombinant adenovirus vector expressing shRNAs targeting COX-2, AKT1 and PIK3R1 gene and its inhibition effect on proliferation of human gastric adenocarcinoma] ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20069397&form=6&db=m Correlation Between Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in Human Colorectal Adenocarcinoma: A Cross-Sectional Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20075740&form=6&db=m COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20095346&form=6&db=m [Inhibitory effects of targeting protein kinase B1 and cyclooxygenase-2 shRNA upon human gastric adenocarcinoma cell growth] ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20359903&form=6&db=m Aspirin and non-small cell lung cancer resections: effect on long-term survival. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20397266&form=6&db=m Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20436219&form=6&db=m Bile acids are multifunctional modulators of the Barrett's carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20686774&form=6&db=m Signet-ring cell carcinoma of colorectum-current perspectives and molecular biology. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716424&form=6&db=m [The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20814068&form=6&db=m Cyclooxygenase-2 (COX-2) is the key event in pathophysiology of Barrett's esophagus. Lesson from experimental animal model and human subjects. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042766&form=6&db=m The ?-adrenoceptor antagonist, propranolol, induces human gastric cancer cell apoptosis and cell cycle arrest via inhibiting nuclear factor ?B signaling. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21071513&form=6&db=m The MIF homologue D-dopachrome tautomerase promotes COX-2 expression through ?-catenin-dependent and -independent mechanisms. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21122290&form=6&db=m [Different proteome of human lung adenocarcinoma cells treated with NS-398 and cisplation.] causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21152137&form=6&db=m Relation of the expression of cyclooxygenase-2 in colorectal adenomas and adenocarcinomas to angiogenesis and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215004&form=6&db=m [Expression of COX-2 and its prognostic significance in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21251407&form=6&db=m [Study of COX-2 expression and angiogenesis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21320400&form=6&db=m [Cyclooxygenase-2 expression in female pulmonary adenocarcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21359892&form=6&db=m Comparison of COX-2, Ki-67, and BCL-2 expression in normal esophageal mucosa, Barrett's esophagus, dysplasia, and adenocarcinoma with postablation mucosa and implications for ablative therapies. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360269&form=6&db=m Expression Profile as Predictor of Relapse after Adjuvant Treatment in Gastric Cancer. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21572400&form=6&db=m Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21589857&form=6&db=m Hypoxia and prostaglandin E receptor 4 signalling pathways synergise to promote endometrial adenocarcinoma cell proliferation and tumour growth. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21654311&form=6&db=m Chicken Skin Mucosa Surrounding Adult Colorectal Adenomas is a Risk Factor for Carcinogenesis. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21689364&form=6&db=m The use of molecular markers as a method to predict the response to neoadjuvant therapy for advanced stage rectal adenocarcinoma. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21760774&form=6&db=m Involvement of COX-2/PGE(2) Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779349&form=6&db=m Smoking and COX-2 Functional Polymorphisms Interact to Increase the Risk of Gastric Cardia Adenocarcinoma in Chinese Population. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21798652&form=6&db=m Cyclooxigenase-2 Levels are Increased in the Lung Tissue and Bronchial Tumors of Patients with Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21853395&form=6&db=m Reply to Letter to the Editor: Re: Comparison of COX-2, Ki-67, and BCL-2 expression in normal esophageal mucosa, Barrett's esophagus, dysplasia, and adenocarcinoma with postablation mucosa and implications for ablative therapies (Online First). therapeutic application,unassigned 1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21916491&form=6&db=m 11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21971589&form=6&db=m Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22081106&form=6&db=m Cyclooxygenase-2 expression in esophageal epithelium before and after photodynamic therapy for Barrett's esophagus with high-grade dysplasia or intramucosal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22133296&form=6&db=m Expression of COX-2 and E-cadherin in Tunisian patients with colorectal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22165968&form=6&db=m Characterization of the Prostaglandin E2 path way in a Rat Model of Esophageal Adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22258871&form=6&db=m Cyclooxygenase Isoenzyme-2 and Vascular Endothelial Growth Factor are Associated with Poor Prognosis in Esophageal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22344367&form=6&db=m Inhibition of cyclooxygenase-2 by tetramethylpyrazine and its effects on A549 cell invasion and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22442729&form=6&db=m Seminal plasma enhances cervical adenocarcinoma cell proliferation and tumour growth in vivo. ongoing research,unassigned 2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22648851&form=6&db=m [An experimental study on chemoprevention of esophageal adenocarcinoma by celecoxib, a selective cyclooxygenase-2 inhibitor]. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22687377&form=6&db=m Celecoxib synergizes human pancreatic ductal adenocarcinoma cells to sorafenib-induced growth inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22699205&form=6&db=m Efficacy of Dimethylaminoparthenolide and Sulindac in Combination With Gemcitabine in a Genetically Engineered Mouse Model of Pancreatic Cancer. causal interaction,unassigned 2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22784710&form=6&db=m Cell Intrinsic Role of Cox-2 in Pancreatic Cancer Development. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22843946&form=6&db=m Association Between COX-2 Expression and Effectiveness of COX-2 Inhibitors in a Phase II Trial in Patients with Metastatic Colorectal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848259&form=6&db=m Sinomenine inhibits proliferation of SGC-7901 gastric adenocarcinoma cells via suppression of cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22901225&form=6&db=m Mechanism of P-glycoprotein Expression in the SGC7901 Human Gastric Adenocarcinoma Cell Line Induced by Cyclooxygenase-2. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22923219&form=6&db=m Expression of BMP2, TLR3, TLR4 and COX2 in colorectal polyps, adenoma and adenocarcinoma. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23002358&form=6&db=m Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23029430&form=6&db=m Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23117827&form=6&db=m Canonical Wnt Signaling Pathway Plays an Essential Role in N-Methyl-N-Nitrosurea Induced Gastric Tumorigenesis of Mice. diagnostic usage,unassigned 1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226798&form=6&db=m Antitumor effect of the selective COX-2 inhibitor celecoxib on endometrial adenocarcinoma in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23289871&form=6&db=m Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349335&form=6&db=m Positional isomers of aspirin are equally potent in inhibiting colon cancer cell growth: differences in mode of cyclooxygenase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23359190&form=6&db=m Impact of COX-2, IL-1?, TNF-?, IL-4 and IL-10 on the process of carcinogenesisin the large bowel. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384501&form=6&db=m Cox-2 in non-small cell lung cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23416011&form=6&db=m A nitrophenyl-based prodrug type for colorectal targeting of prednisolone, budesonide and celecoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23778258&form=6&db=m COX-2 expression in canine anal sac adenocarcinomas and in non-neoplastic canine anal sacs. therapeutic application,unassigned 1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24040391&form=6&db=m The Anti-Tumor Effect of HDAC Inhibition in a Human Pancreas Cancer Model Is Significantly Improved by the Simultaneous Inhibition of Cyclooxygenase 2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24212953&form=6&db=m Inflammation-related carcinogenesis and prevention in esophageal adenocarcinoma using rat duodenoesophageal reflux models. therapeutic application,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24387269&form=6&db=m Cyclooxygenase-2 and B-cell lymphoma-2 expression in cystitis glandularis and primary vesicle adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649093&form=6&db=m Effect of celecoxib plus standard chemotherapy on serum levels of vascular endothelial growth factor and cyclooxygenase-2 in patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24651385&form=6&db=m Cyclooxygenase inhibitors use is associated with reduced risk of esophageal adenocarcinoma in patients with Barrett's esophagus: a meta-analysis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681073&form=6&db=m Preference of Endoscopic Ablation Over Medical Prevention of Esophageal Adenocarcinoma by Patients with Barrett's Esophagus. therapeutic application,unassigned 2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24792472&form=6&db=m Cyclooxygenase 2-mediated apoptotic and inflammatory responses in photodynamic therapy treated breast adenocarcinoma cells and xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24834195&form=6&db=m Influence of age and gender on association between -765G > C COX-2 genetic polymorphism and gastric adenocarcinoma risk: a case-control study in Iran. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24932579&form=6&db=m A role for cAMP-driven transactivation of EGFR in cancer aggressiveness - therapeutic implications. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24950702&form=6&db=m COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24992958&form=6&db=m Cyclooxygenase-2 inhibition as a strategy for treating gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25142612&form=6&db=m Apoptotic effects of two COX-2 inhibitors on breast adenocarcinoma cells through COX-2 independent pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25169526&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in colorectal adenocarcinoma: an immunohistochemical and histopathological study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25266020&form=6&db=m Strategy for prevention of cancers of the esophagus. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25276196&form=6&db=m Cytotoxicity of selected novel chalcone derivatives on human breast, lung and hepatic carcinoma cell lines. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310697&form=6&db=m Inflammation and MiR-21 pathways functionally interact to downregulate PDCD4 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25356937&form=6&db=m A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25427631&form=6&db=m Guggulsterone, a plant-derived inhibitor of NF-TB, suppresses CDX2 and COX-2 expression and reduces the viability of esophageal adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25683901&form=6&db=m Immunohistochemical Expression of Cyclooxygenase-2 (COX-2) in Feline Endometrial Adenocarcinoma and in Normal and Hyperplastic Endometria. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25910300&form=6&db=m Relationship between HER-2, COX-2, p53 and clinicopathologic features in gastric adenocarcinoma. Do these biomarkers have any prognostic significance? diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25949900&form=6&db=m Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against ?? T cell cytotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26429877&form=6&db=m Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26550460&form=6&db=m Upregulation of cyclooxygenase-2 is associated with activation of the alternative nuclear factor kappa B signaling pathway in colonic adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26601088&form=6&db=m An investigation of the rate of cyclooxygenase-2 expression on the surface of adenomatous and colorectal adenocarcinoma polyps. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26675757&form=6&db=m HuR mediated post-transcriptional regulation as a new potential adjuvant therapeutic target in chemotherapy for pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,2
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680871&form=6&db=m Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680965&form=6&db=m Expression of Cyclooxygenase-2 and Tumor Microvessel Density in Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26792840&form=6&db=m Pathologic Features of Colorectal Inflammatory Polyps in Miniature Dachshunds. causal interaction,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893718&form=6&db=m Picfeltarraenin IA inhibits lipopolysaccharide-induced inflammatory cytokine production by the nuclear factor-?B pathway in human pulmonary epithelial A549 cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26914122&form=6&db=m Anti-reflux anastomosis following esophagectomy for adenocarcinoma of the esophagogastric junction: impact of duodenogastroesophageal reflux and expression of cyclooxygenase-2 in the remnant esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27057636&form=6&db=m Sp1 and COX2 expression is positively correlated with a poor prognosis in pancreatic ductal adenocarcinoma. causal interaction,unassigned 1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27153549&form=6&db=m Predictive value of APAF-1 and COX-2 expression in pathologic complete response to neoadjuvant chemoradiotherapy for patients with locally advanced rectal adenocarcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314294&form=6&db=m Clinical and prognosis relevance of COX-2 expression in Tunisian patients with primary gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27342370&form=6&db=m Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma: Relationship with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27554763&form=6&db=m Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27854106&form=6&db=m Expression of cyclooxygenase-2 has no impact on survival in adenocarcinoma of the esophagogastric junction but is associated with favourable clinicopathologic features. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28201358&form=6&db=m Molecular Characterization of Canine Prostaglandin G/H Synthase-2 and Regulation in Prostatic Adenocarcinoma Cells in Vitro. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28222855&form=6&db=m Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism. ongoing research,unassigned 2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28239316&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272681&form=6&db=m Correlation of COX- 2 Expression in Colorectal Carcinoma with Clinicopathological Features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254791&form=6&db=m Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29279587&form=6&db=m Cyclooxygenase-2 (COX2) expression in adenocarcinoma surpasses that of squamous cell carcinoma in the uterine cervix. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29324448&form=6&db=m The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29765153&form=6&db=m COX-2 mediates pro-tumorigenic effects of PKC? in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767663&form=6&db=m COX-2 gene expression and methylation profile in Sapajus apella as an experimental model for gastric adenocarcinoma. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231491&form=6&db=m The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice. ongoing research,unassigned 2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402808&form=6&db=m Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30408225&form=6&db=m High PTGS2 expression in post-neoadjuvant chemotherapy-treated oesophageal adenocarcinoma is associated with improved survival: a population-based cohort study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30798928&form=6&db=m Possible role of PPAR-? and COX-2 receptor modulators in the treatment of Non-Small Cell lung carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30972191&form=6&db=m Alterations of COX-2, HER-2/neu and E-Cadherin protein expression in the prostatic adenocarcinoma: preliminary findings. causal interaction,unassigned 4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30982333&form=6&db=m Cyclo-oxygenase-2 expression is associated with mean standardised uptake value on 18F-Fluorodeoxyglucose positron emission tomography in oesophageal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186753&form=6&db=m EGFR, but not COX-2, protein in resected pancreatic ductal adenocarcinoma is associated with poor survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31289003&form=6&db=m Expression of PCNA, Ki-67 and COX-2 in breast cancer based on DCE-MRI image information. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31313480&form=6&db=m Phthalate plasticizer di(2-ethyl-hexyl) phthalate induces cyclooxygenase-2 expression in gastric adenocarcinoma cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32199598&form=6&db=m Cyclooxigenase-2 and osteopontin in gastric pre-neoplastic lesions in relation to H-pylori infection and grade of inflammation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32433831&form=6&db=m Expression of cyclooxygenase-2 in imprint smears of endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33062161&form=6&db=m Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441691&form=6&db=m Lipid droplet biogenesis and COX-2 pathway activation are triggered by Barrett's esophagus and adenocarcinoma, but not esophageal squamous cell carcinoma risk factors. unassigned -
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9062364&form=6&db=m Interferon gamma induces prostaglandin G/H synthase-2 through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823297&form=6&db=m Expression of cyclooxygenase-2 in human lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353732&form=6&db=m Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515422&form=6&db=m Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874016&form=6&db=m Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585835&form=6&db=m Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1.0 cells. Involvement of phosphatidylinositol 3-kinase/Akt pathway. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891209&form=6&db=m Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11911489&form=6&db=m Arsenite pretreatment attenuates benzo[a]pyrene cytotoxicity in a human lung adenocarcinoma cell line by decreasing cyclooxygenase-2 levels. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130685&form=6&db=m Transcriptional regulation of basal cyclooxygenase-2 expression in murine lung tumor-derived cell lines by CCAAT/enhancer-binding protein and activating transcription factor/cAMP response element-binding protein. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12144868&form=6&db=m Downregulation of COX-2 and iNOS by amentoflavone and quercetin in A549 human lung adenocarcinoma cell line. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369871&form=6&db=m Selective cyclooxygenase-2 inhibitors and non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12672646&form=6&db=m Protection by quercetin against cooking oil fumes-induced DNA damage in human lung adenocarcinoma CL-3 cells: role of COX-2. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566258&form=6&db=m Cyclooxygenase-2 inhibition decreases primary and metastatic tumor burden in a murine model of orthotopic lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14567645&form=6&db=m Evaluation of an aerosolized selective COX-2 inhibitor as a potentiator of doxorubicin in a non-small-cell lung cancer cell line. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744769&form=6&db=m Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15331179&form=6&db=m Prostaglandin E2 activates Src signaling in lung adenocarcinoma cell via EP3. causal interaction,unassigned 4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16076764&form=6&db=m Cooking oil fumes improve lung adenocarcinoma cell survival through c-IAP2 induction. causal interaction,unassigned 3,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16536899&form=6&db=m Anti-cancer effect of celecoxib and aerosolized docetaxel against human non-small cell lung cancer cell line, A549. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632868&form=6&db=m Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707460&form=6&db=m Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16844092&form=6&db=m Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201164&form=6&db=m Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363603&form=6&db=m Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17632087&form=6&db=m Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18345025&form=6&db=m Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18348652&form=6&db=m NS-398 enhances the efficacy of gemcitabine against lung adenocarcinoma through up-regulation of p21WAF1 and p27KIP1 protein. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18424438&form=6&db=m NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18478928&form=6&db=m [Effects of RNA interference of COX-2 gene expression on malignant proliferation of A549 cells in vitro] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19543119&form=6&db=m Bronchioloalveolar carcinoma (lepidic growth) component is a more useful prognostic factor than lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19685508&form=6&db=m Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via VEGF-C. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631885&form=6&db=m Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664959&form=6&db=m The immune modulation of Clara cell-10 in human peripheral monocytes and dendritic cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716400&form=6&db=m [The Effects of Interfering COX-2 Gene Expression on Malignant Proliferation of Human Lung Adenocarcinoma A2 Cell in vitro.] causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21320400&form=6&db=m [Cyclooxygenase-2 expression in female pulmonary adenocarcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426663&form=6&db=m [The Expression and Clinical Significance of HIF-1?, COX-2 and E-cadherin in Patients with Lung Adenocarcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21617857&form=6&db=m EGF stimulates cyclooxygenase-2 expression through the STAT5 signaling pathway in human lung adenocarcinoma A549 cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22206958&form=6&db=m Maximal standardized uptake value on FDG-PET is correlated with cyclooxygenase-2 expression in patients with lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22267101&form=6&db=m Cinobufocini inhibits NF-?B and COX-2 activation induced by TNF-? in lung adenocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22696230&form=6&db=m Galectin-1 Promotes Lung Cancer Progression and Chemoresistance by Upregulating p38 MAPK, ERK, and Cyclooxygenase-2. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22704420&form=6&db=m Effects of Feiyanning Decoction, a compound traditional Chinese medicine, on iNOS and COX-2 expressions induced by tumor necrosis factor-? in lung adenocarcinoma cell line. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23092161&form=6&db=m Anti-Cancer Effects of a New Docosahexaenoic Acid Monoacylglyceride in Lung Adenocarcinoma. causal interaction,unassigned 3,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23601296&form=6&db=m [Mechanisms of EGF regulation of COX-2 through the STAT5 signaling pathway in human lung adenocarcinoma A549 cells]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24384873&form=6&db=m Thromboxane A2 exerts promoting effects on cell proliferation through mediating cyclooxygenase-2 signal in lung adenocarcinoma cells. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24704993&form=6&db=m MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25392182&form=6&db=m Difference in prognostic values of maximal standardized uptake value on fluorodeoxyglucose-positron emission tomography and cyclooxygenase-2 expression between lung adenocarcinoma and squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25445582&form=6&db=m Oral administration of aflatoxin G? induces chronic alveolar inflammation associated with lung tumorigenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25544576&form=6&db=m TGF-? Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells. ongoing research,unassigned 4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25797267&form=6&db=m Ku80 cooperates with CBP to promote COX-2 expression and tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26022894&form=6&db=m Comparative Expression of Apoptotic Markers in Lung Adenocarcinoma and Squamous Cell Carcinoma. diagnostic usage,therapeutic application,unassigned 1,2,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26191267&form=6&db=m Monitoring of cyclooxygenase-2 levels can predict EGFR mutations and the efficacy of EGFR-TKI in patients with lung adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464643&form=6&db=m Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 Level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27554763&form=6&db=m Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29025423&form=6&db=m Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29238224&form=6&db=m Prognostic value of Cox-2 and PD-L1 expression and its relationship with tumor-infiltrating lymphocytes in resected lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872310&form=6&db=m Resveratrol inhibits the proliferation of A549 cells by inhibiting the expression of COX-2. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31163629&form=6&db=m Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma. causal interaction,unassigned 4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31202132&form=6&db=m Carvacrol encapsulated nanocarrier/ nanoemulsion abrogates angiogenesis by downregulating COX-2, VEGF and CD31 in vitro and in vivo in a lung adenocarcinoma model. unassigned -
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32619204&form=6&db=m Optimized Curcumin, Pomegranate Extract, and Methylsulfonylmethane Reduce Acute, Systemic Inflammatory Response to a Half-marathon Race. diagnostic usage,unassigned 3,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802118&form=6&db=m Study on the Mechanism of Ginseng in the Treatment of Lung Adenocarcinoma Based on Network Pharmacology. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32904445&form=6&db=m Inhibition of PI3K-AKT Signaling Blocks PGE2-Induced COX-2 Expression in Lung Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenocarcinoma, Bronchiolo-Alveolar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10767270&form=6&db=m Inhaled indomethacin in bronchorrhea in bronchioloalveolar carcinoma: role of cyclooxygenase. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Adenocarcinoma, Bronchiolo-Alveolar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11086200&form=6&db=m Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Adenocarcinoma, Bronchiolo-Alveolar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15763434&form=6&db=m Dietary lipids modulate eicosanoid release and apoptosis of cells of a murine lung alveolar carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma, Clear Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12469191&form=6&db=m Expression of cyclooxygenase-2 and its relationship to p53 accumulation in ovarian adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenocarcinoma, Mucinous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11881728&form=6&db=m Increased expression of cyclooxygenase-2 in human salivary gland tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenocarcinoma, Mucinous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17617879&form=6&db=m Simultaneous adeno- and squamous cell carcinoma with different phenotypic profiles in a rat model of chronic gastroesophageal reflux. therapeutic application,unassigned 1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7926468&form=6&db=m Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8631005&form=6&db=m G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. causal interaction,unassigned 4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8653697&form=6&db=m Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8831610&form=6&db=m Elevated cyclooxygenase-2 levels in Min mouse adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9563494&form=6&db=m Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589361&form=6&db=m Colon cancer chemoprevention: clinical development of aspirin as a chemopreventive agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589912&form=6&db=m Chemopreventive effects of NSAIDs against colorectal cancer: regulation of apoptosis and mitosis by COX-1 and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679948&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9739782&form=6&db=m Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027203&form=6&db=m Chemoprevention of colorectal cancer: dietary and pharmacologic approaches. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10069452&form=6&db=m Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188882&form=6&db=m Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10197601&form=6&db=m Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet. causal interaction,unassigned 4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10225537&form=6&db=m Specific COX-2 inhibitors in arthritis, oncology, and beyond: where is the science headed? causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390128&form=6&db=m The clinical potential of cyclooxygenase-2-specific inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398082&form=6&db=m Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419916&form=6&db=m Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10508481&form=6&db=m High expression of cyclooxygenase-2 in macrophages of human colonic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597402&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10607736&form=6&db=m A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630181&form=6&db=m Chemoprevention in hereditary colorectal cancer syndromes. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10666384&form=6&db=m Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10695990&form=6&db=m Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10753183&form=6&db=m High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766173&form=6&db=m Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10797271&form=6&db=m Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861445&form=6&db=m Increased levels of promutagenic etheno-DNA adducts in colonic polyps of FAP patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864362&form=6&db=m Immunohistochemical expression of cyclooxygenase (COX)-2 in colorectal adenomas. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873632&form=6&db=m Prostaglandins up-regulate vascular endothelial growth factor production through distinct pathways in differentiated U937 cells. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874009&form=6&db=m Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874016&form=6&db=m Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10965822&form=6&db=m Effect of prostaglandin E1 on vascular endothelial growth factor production by human macrophages and colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980113&form=6&db=m The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016626&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032917&form=6&db=m Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11045053&form=6&db=m COX-2 inhibitors: a potential target for drug therapy in the management of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11052981&form=6&db=m Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11129221&form=6&db=m Relationship between cyclooxygenase-2 expression and K-ras gene mutation in colorectal adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159736&form=6&db=m Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11180079&form=6&db=m Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223821&form=6&db=m Expression of cyclooxygenase-2 in human gastric adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301836&form=6&db=m COX-2 inhibition in clinical cancer prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309440&form=6&db=m Testing for colon neoplasia susceptibility variants at the human COX2 locus. therapeutic application,unassigned 2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11324434&form=6&db=m Colorectal cancer and non-steroidal anti-inflammatory drugs. causal interaction,unassigned 4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11328256&form=6&db=m Surveillance colonoscopy or chemoprevention with COX-2 inhibitors in average-risk post-polypectomy patients: a decision analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11397667&form=6&db=m Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11495083&form=6&db=m Enhanced cyclooxygenase-2 expression in sporadic and familial adenomatous polyposis of the human colon. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11497255&form=6&db=m Indomethacin reduces lung adenoma number in A/J mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11506952&form=6&db=m Expression of cyclooxygenase-2 (COX-2) mRNA in human colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507063&form=6&db=m Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584208&form=6&db=m Cyclooxygenase-2 is overexpressed in serrated adenoma of the colorectum. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687954&form=6&db=m A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751489&form=6&db=m Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751493&form=6&db=m Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809702&form=6&db=m Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920515&form=6&db=m Immunohistochemical analysis and in situ hybridization of cyclooxygenase-2 expression in intraductal papillary-mucinous tumors of the pancreas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11939728&form=6&db=m Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966530&form=6&db=m Review article: COX-2, prostanoids and colon cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992750&form=6&db=m Screening for colon cancer and evaluation of chemoprevention with coxibs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12031082&form=6&db=m Size-dependent expression of cyclooxygenase-2 in sporadic colorectal adenomas relative to adenomas in patients with familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12049307&form=6&db=m Comparison of cyclo-oxygenase 2 expression in colorectal serrated adenomas to expression in tubular adenomas and hyperplastic polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066205&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126145&form=6&db=m Cyclooxygenase-2 expression in spontaneous intestinal neoplasia of domestic dogs. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12145422&form=6&db=m Chemoprevention in colorectal neoplasias: what is practical and feasible? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12151354&form=6&db=m The role of cyclooxygenase-2 (COX-2) in two different morphological stages of intestinal polyps in APC(Delta474) knockout mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12174906&form=6&db=m Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12370807&form=6&db=m Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12394429&form=6&db=m Analysis of cyclooxygenase expression in human colorectal adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434411&form=6&db=m Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434412&form=6&db=m Interstitial cell cyclooxygenase-2 expression is associated with increased angiogenesis in human sporadic colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12629931&form=6&db=m Cyclooxygenase-2: from arthritis treatment to new indications for the prevention and treatment of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12635357&form=6&db=m [Prophylaxis of colorectal cancer with non steroidal anti-inflammatory drugs- a new reality?] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637762&form=6&db=m Cyclooxygenase-2 expression in canine mammary tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713627&form=6&db=m Cyclooxygenase-2 expression in thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12746190&form=6&db=m Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767095&form=6&db=m Cyclooxygenase-2 expression in human pituitary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12778076&form=6&db=m Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794581&form=6&db=m Cyclooxygenase-2 expression in colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810622&form=6&db=m Cyclooxygenase-2 expression and effect of celecoxib in gastric adenomas of trefoil factor 1-deficient mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12837940&form=6&db=m Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12873979&form=6&db=m Association between Cyclooxygenase expression and colorectal adenoma characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891542&form=6&db=m The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902846&form=6&db=m Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970891&form=6&db=m Role of COX-2 in carcinogenesis of colorectal cancer and its relationship with tumor biological characteristics and patients' prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14506383&form=6&db=m Cyclo-oxygenase inhibition in colorectal adenomas and cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14564639&form=6&db=m Superficially elevated colonic adenoma changed to undetectable configuration on ordinary endoscopy during treatment with preferential cyclooxygenase-2 inhibitor. therapeutic application,unassigned 3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14616542&form=6&db=m Cyclooxygenase-2 and gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717230&form=6&db=m Immunohistochemical expression of COX-2 in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14722849&form=6&db=m Colon polyps and cancer. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14769841&form=6&db=m Cyclooxygenase-2 expression and its relationship with proliferation of colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14986031&form=6&db=m E-cadherin expression is homogeneously reduced in adenoma from patients with familial adenomatous polyposis: an immunohistochemical study of E-cadherin, beta-catenin and cyclooxygenase-2 expression. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15054500&form=6&db=m Colorectal polyposis and immune-based therapies. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15122305&form=6&db=m Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15167166&form=6&db=m The relationship between cyclooxygenase-2 expression and characteristics of malignant transformation in human colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15274307&form=6&db=m Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; correlation with intratumoral microvessel density and apoptotic index. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15299197&form=6&db=m Expression of cyclooxygenase-2 and thromboxane synthase in non-neoplastic and neoplastic thyroid lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15309515&form=6&db=m Prevention of colorectal cancer through the use of COX-2 selective inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15340847&form=6&db=m Cyclooxygenase-2 and its role in colorectal cancer development. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15353307&form=6&db=m Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355919&form=6&db=m Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15361286&form=6&db=m Relationship between COX-2 expression and clinicopathological features of colorectal cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501074&form=6&db=m COX-2 inhibition as a tool to treat and prevent colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15505432&form=6&db=m [Cyclooxygenase-2 expression according to size and location of gastric and colorectal tubular adenomas] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539957&form=6&db=m WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth. causal interaction,unassigned 2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15550453&form=6&db=m Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585629&form=6&db=m Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637091&form=6&db=m Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15668484&form=6&db=m Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. unassigned -
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15688382&form=6&db=m Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells. ongoing research,unassigned 1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695237&form=6&db=m Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15713943&form=6&db=m Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716238&form=6&db=m Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15726503&form=6&db=m Colorectal cancer prevention: is an ounce of prevention worth a pound of cure? causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753380&form=6&db=m Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767339&form=6&db=m PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15800927&form=6&db=m E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15800939&form=6&db=m Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15807932&form=6&db=m A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817909&form=6&db=m High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15894675&form=6&db=m Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15913419&form=6&db=m Immunohistochemical expression of cyclooxygenase 2 in follicular carcinomas of the thyroid. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930344&form=6&db=m Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947945&form=6&db=m Cyclooxygenase-2 in normal, hyperplastic and neoplastic follicular cells of the human thyroid gland. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15951464&form=6&db=m The cardiovascular toxicity of selective and nonselective cyclooxygenase inhibitors: comparisons, contrasts, and aspirin confounding. therapeutic application,unassigned 4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000571&form=6&db=m Cyclooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16042585&form=6&db=m Is COX-2 a 'collateral' target in cancer prevention? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16049962&form=6&db=m Nuclear factor kappaB is downregulated and correlates with p53 in the Min mouse mucosa during an accelerated tumor growth. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16085694&form=6&db=m Monocyte chemoattractant protein 1 and macrophage cyclooxygenase 2 expression in colonic adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103460&form=6&db=m Cyclooxygenase-2 expression in FAP patients carrying germ line MYH mutations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16110762&form=6&db=m Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136748&form=6&db=m Cyclooxygenase-2 in sporadic colorectal polyps: immunohistochemical study and its importance in the early stages of colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139560&form=6&db=m Hepatocyte growth factor expression correlates with cyclooxygenase-2 pathway in human salivary gland tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16158946&form=6&db=m Cyclooxygenase-2 expression is associated with increased size in human sporadic colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16205694&form=6&db=m Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219637&form=6&db=m Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16266236&form=6&db=m Cyclooxygenase-2 inhibition in colon experimental carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16295777&form=6&db=m Expression of Cyclooxygenase-2 and Bcl-2 in human gastric adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16362262&form=6&db=m Cyclooxygenase 1 and 2 expressions in the human thyroid gland. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16387490&form=6&db=m Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas: Modification by dietary curcumin and implications for clinical trials. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16482563&form=6&db=m Polymorphisms in the genes involved in the arachidonic acid-pathway, fish consumption and the risk of colorectal cancer. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16540660&form=6&db=m Increased EP4 Receptor Expression in Colorectal Cancer Progression Promotes Cell Growth and Anchorage Independence. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618816&form=6&db=m Use of first- and second-generation cyclooxygenase-2-selective nonsteroidal antiinflammatory drugs and risk of acute myocardial infarction. therapeutic application,unassigned 4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622748&form=6&db=m Does a selective cyclooxygenase-2 inhibitor (tiracoxib) induce clinically sufficient suppression of adenomas in patients with familial adenomatous polyposis? A randomized double-blind placebo-controlled clinical trial. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16714876&form=6&db=m [Cyclo-oxygenase-2 and p53 immunoreactivity in superficial early colorectal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16757216&form=6&db=m Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16760271&form=6&db=m Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778222&form=6&db=m Changes in antitumor response in C57BL/6J-Min/+ mice during long-term administration of a selective cyclooxygenase-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818642&form=6&db=m Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16943394&form=6&db=m Effect of celecoxib on cardiovascular events and blood pressure in two trials for the prevention of colorectal adenomas. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16943400&form=6&db=m Celecoxib for the prevention of sporadic colorectal adenomas. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16985035&form=6&db=m Immunohistochemical expressions of Ki-67, cyclin D1, beta-catenin, cyclooxygenase-2, and epidermal growth factor receptor in human colorectal adenoma: a validation study of tissue microarrays. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049779&form=6&db=m Increased expression of cyclooxygenase-2 and Ki-67 are associated with malignant transformation of pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17087947&form=6&db=m A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17133084&form=6&db=m Chemoprevention of colorectal neoplasia: advances and controversies (the COX-2 story). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17179688&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in thyroid neoplasms and their clinicopathological correlation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17277229&form=6&db=m Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17302187&form=6&db=m Cox-2 and cancer chemoprevention: picking up the pieces. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17339623&form=6&db=m Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17378912&form=6&db=m Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17487390&form=6&db=m A reduced COX-2 expression and a reduced number of pericryptal myofibroblasts are associated with depressed adenoma of the colon. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504375&form=6&db=m Cell proliferation activity unrelated to COX-2 expression in ovarian tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17579859&form=6&db=m Distinct changes of dendritic cell number and IL-12 mRNA level in adjacent mucosa throughout the colorectal adenoma-carcinoma sequence. unassigned -
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640058&form=6&db=m Polymorphisms in PTGS1, PTGS2 and IL-10 do not influence colorectal adenoma recurrence in the context of a randomized aspirin intervention trial. therapeutic application,unassigned 3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640979&form=6&db=m HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17711445&form=6&db=m Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875695&form=6&db=m Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17923032&form=6&db=m [Selective cyclooxygenase-2 inhibitors for the prevention of colorectal adenomas: a meta-analysis] causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952153&form=6&db=m [Prevention and early diagnosis of colorectal cancer] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17955050&form=6&db=m Cyclooxygenase-2 overexpression abrogates the antiproliferative effects of TGF-beta. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962941&form=6&db=m Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058473&form=6&db=m Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094611&form=6&db=m Increased expression of cytoplasmic HuR in familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159171&form=6&db=m [COX-2 inhibitors in inflammatory bowel disease: friends or foes?] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167131&form=6&db=m Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: the Self Defense Forces Health Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18214062&form=6&db=m hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230181&form=6&db=m Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18395100&form=6&db=m Chemoprevention of colorectal neoplasia: the potential for personalized medicine. causal interaction,unassigned 3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462368&form=6&db=m COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18551182&form=6&db=m The Roles of Dietary PPARgamma Ligands for Metastasis in Colorectal Cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19031967&form=6&db=m Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19124115&form=6&db=m Increased cyclooxygenase-2 expression in juvenile polyposis syndrome. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138958&form=6&db=m Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148797&form=6&db=m NSAIDs and colorectal cancer prevention. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19205707&form=6&db=m Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208339&form=6&db=m The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268443&form=6&db=m Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19307727&form=6&db=m Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336730&form=6&db=m Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19470469&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536452&form=6&db=m Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms. diagnostic usage,unassigned 1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19606728&form=6&db=m [Chemoprevention of colorectal cancer] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671325&form=6&db=m [Expression of cyclooxygenase-2 and relationship with mismatch repaire gene and microsatellite instability in hereditary non-polyposis colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19755647&form=6&db=m Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19757048&form=6&db=m Chemoprevention of Colonic Polyps with Balsalazide: An Exploratory, Double-Blind, Placebo-Controlled Study. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19765361&form=6&db=m NSAIDs and the gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895739&form=6&db=m [Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956499&form=6&db=m Co-Expression of Cox-2, C-Met and beta-catenin in Cells Forming Invasive front of Gallbladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20046424&form=6&db=m Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20087348&form=6&db=m Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20427388&form=6&db=m COX-2 expression in adenoma: an imperfect marker for chemoprevention. diagnostic usage,unassigned 1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20427397&form=6&db=m Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20484034&form=6&db=m Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20496537&form=6&db=m Chemoprophylaxis in gastrointestinal tumors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20640858&form=6&db=m Diagnostic utility of immunohistochemical panel in various thyroid pathologies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20681671&form=6&db=m Pterostilbene inhibits colorectal aberrant crypt foci (ACF) and colon carcinogenesis via suppression of multiple signal transduction pathways in azoxymethane-treated mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20864903&form=6&db=m Expression of cyclooxygenase-2 in colonic polyps. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20924971&form=6&db=m Colorectal cancer: chemopreventive role of curcumin and resveratrol. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21133589&form=6&db=m Cyclooxygenase-2 expression in gastrointestinal stromal tumours. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21152137&form=6&db=m Relation of the expression of cyclooxygenase-2 in colorectal adenomas and adenocarcinomas to angiogenesis and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21158711&form=6&db=m Cyclooxygenase as a Target for Colorectal Cancer Chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21435744&form=6&db=m [Aspirin in the prevention of colorectal cancer.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459756&form=6&db=m Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21562034&form=6&db=m Chemopreventive Efficacy and Mechanism of Licofelone in a Mouse Lung Tumor Model via Aspiration. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21573497&form=6&db=m Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21654311&form=6&db=m Chicken Skin Mucosa Surrounding Adult Colorectal Adenomas is a Risk Factor for Carcinogenesis. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21679035&form=6&db=m Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21730361&form=6&db=m COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22034055&form=6&db=m Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22082586&form=6&db=m ?-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228906&form=6&db=m Decreased Toll-interacting protein and peroxisome proliferator-activated receptor ? are associated with increased expression of Toll-like receptors in colon carcinogenesis. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22376259&form=6&db=m Linkage Disequilibrium and Haplotype Analysis of COX-2 and Risk of Colorectal Adenoma Development. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22551900&form=6&db=m A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22667343&form=6&db=m Immunohistochemical study of cyclooxygenase-2 in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22923219&form=6&db=m Expression of BMP2, TLR3, TLR4 and COX2 in colorectal polyps, adenoma and adenocarcinoma. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23010081&form=6&db=m Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR. therapeutic application,unassigned 4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23060037&form=6&db=m Design and baseline characteristics of participants in a phase III randomized trial of celecoxib and selenium for colorectal adenoma prevention. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23359190&form=6&db=m Impact of COX-2, IL-1?, TNF-?, IL-4 and IL-10 on the process of carcinogenesisin the large bowel. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23516071&form=6&db=m ß-catenin, Cox-2 and p53 immunostaining in colorectal adenomas to predict recurrence after endoscopic polypectomy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23595116&form=6&db=m Molecular Pathways and Cellular Metabolism in Colorectal Cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23741059&form=6&db=m Epithelial-Specific Deletion of 11?-HSD2 Hinders Apcmin/+ Mouse Tumorigenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23936870&form=6&db=m 11?-Hydroxysteroid Dehydrogenase Type II is a Potential Target for Prevention of Colorectal Tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23975167&form=6&db=m Potential targets for colorectal cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24486542&form=6&db=m Lack of anti-tumor activity with the ?-catenin expression inhibitor EZN-3892 in the C57BL/6J Min/+ model of intestinal carcinogenesis. causal interaction,unassigned 1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24488384&form=6&db=m Immunoexpression of the COX-2, p53, and caspase-3 proteins in colorectal adenoma and non-neoplastic mucosa. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24824420&form=6&db=m COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085205&form=6&db=m CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25092825&form=6&db=m Molecular markers of carcinogenesis for risk stratification of individuals with colorectal polyps: a case-control study. causal interaction,diagnostic usage,unassigned 2,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25166592&form=6&db=m Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25693081&form=6&db=m Is there a place for practical chemoprevention of colorectal cancer in light of COX-2 heterogeneity? causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25784839&form=6&db=m Cyclooxygenase-2 immunohistochemical expression in serrated polyps of the colon. unassigned -
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25855137&form=6&db=m Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(?716) mice involves stromal COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26672726&form=6&db=m Consensus on the Prevention, Screening, Early Diagnosis and Treatment of Colorectal Tumors in China: Chinese Society of Gastroenterology, October 14-15, 2011, Shanghai, China. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680871&form=6&db=m Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26792840&form=6&db=m Pathologic Features of Colorectal Inflammatory Polyps in Miniature Dachshunds. causal interaction,unassigned 4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26925134&form=6&db=m Expression of COX-2, IL-1?, TNF-? and IL-4 in epithelium of serrated adenoma, adenoma and hyperplastic polyp. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27479195&form=6&db=m Comparison of biomarker expression between proximal and distal colorectal adenomas: The Tennessee-Indiana Adenoma Recurrence Study. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28139497&form=6&db=m The expression and significance of feces cyclooxygensae-2 mRNA in colorectal cancer and colorectal adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28239316&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28729694&form=6&db=m Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc (Min/+) mouse model of intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927131&form=6&db=m Protein expression of Fragile Histidine Triad and cyclooxgenase-2 in serrated neoplasia of the colorectum. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28948694&form=6&db=m Pomegranate By-Products in Colorectal Cancer Chemoprevention: Effects in Apc-Mutated Pirc Rats and Mechanistic Studies In Vitro and Ex Vivo. ongoing research,unassigned 3,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29137605&form=6&db=m Effects of aspirin and non-aspirin nonsteroidal anti-inflammatory drugs on the incidence of recurrent colorectal adenomas: a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials. therapeutic application,unassigned 4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29421522&form=6&db=m Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2), a complex target for colorectal cancer prevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29769213&form=6&db=m Chemopreventive Efficacy of the Cyclooxygenase-2 (Cox-2) Inhibitor, Celecoxib, Is Predicted by Adenoma Expression of Cox-2 and 15-PGDH. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30106414&form=6&db=m Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients. An experience from Western Saudi Arabia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149368&form=6&db=m Pharmacological and dietary factors in prevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231491&form=6&db=m The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice. ongoing research,unassigned 2,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32917645&form=6&db=m Inflammation Modulation by Vitamin D and Calcium in the Morphologically Normal Colorectal Mucosa of Colorectal Adenoma Patients in a Clinical Trial. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Adenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33579312&form=6&db=m Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Adenoma, Oxyphilic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645803&form=6&db=m Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15380175&form=6&db=m Expression of cyclooxygenase-2, Bcl-2 and Ki-67 in pleomorphic adenoma with special reference to tumor proliferation and apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15562904&form=6&db=m Elevated expression of cyclooxygenase-2 in adenocarcinoma of the parotid gland: insights into malignant transformation of pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880952&form=6&db=m Cyclooxygenase-2 regulates the degree of apoptosis by modulating bcl-2 protein in pleomorphic adenoma and mucoepidermoid carcinoma of the parotid gland. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139560&form=6&db=m Hepatocyte growth factor expression correlates with cyclooxygenase-2 pathway in human salivary gland tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049779&form=6&db=m Increased expression of cyclooxygenase-2 and Ki-67 are associated with malignant transformation of pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17448140&form=6&db=m Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25102875&form=6&db=m [Expression and clinical significance of Cox-2 and XIAP in malignant tumors of the salivary gland]. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003391&form=6&db=m Differential expression of cyclooxygenase-2 and cyclin D1 in salivary gland tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367261&form=6&db=m Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31792484&form=6&db=m [Expression of CD44v6 and COX-2 in pleomorphic adenomas and carcinomas of parotid gland]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Adenoma, Pleomorphic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435431&form=6&db=m Evaluation of VEGF expression correlates with COX-2 expression in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Adenoma, Villous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1932494&form=6&db=m [Treatment with indomethacin for the control of the metabolic disorder caused by a villous adenoma of the rectum] causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Adenoma, Villous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7227779&form=6&db=m Prostaglandin E2-mediated secretory diarrhea in villous adenoma of rectum: effect of treatment with indomethacin. unassigned -
1.14.99.1 Adenoma, Villous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12394429&form=6&db=m Analysis of cyclooxygenase expression in human colorectal adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8653697&form=6&db=m Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8945508&form=6&db=m Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589361&form=6&db=m Colon cancer chemoprevention: clinical development of aspirin as a chemopreventive agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,2
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9809998&form=6&db=m The inducible prostaglandin biosynthetic enzyme, cyclooxygenase 2, is not mutated in patients with attenuated adenomatous polyposis coli. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831333&form=6&db=m COX-2 and colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10204802&form=6&db=m Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419916&form=6&db=m Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10444394&form=6&db=m Myofibroblasts. II. Intestinal subepithelial myofibroblasts. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493305&form=6&db=m Oxidative stress in familial adenomatous polyposis. causal interaction,unassigned 1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582771&form=6&db=m Nimesulide, a selective anti-inflammatory cyclooxygenase-2 inhibitor, does not affect polyp number and mucosal proliferation in familial adenomatous polyposis. therapeutic application,unassigned 4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678579&form=6&db=m Molecular pathology of cyclooxygenase-2 in neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766173&form=6&db=m Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874062&form=6&db=m The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10956391&form=6&db=m Germline alterations in the cyclooxygenase-2 gene are not associated with the development of extracolonic manifestations in a large swiss familial adenomatous polyposis kindred. unassigned -
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980113&form=6&db=m The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016626&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11113106&form=6&db=m Chemoprevention comes to clinical practice: COX-2 inhibition in familial adenomatous polyposis. therapeutic application,unassigned 2,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301836&form=6&db=m COX-2 inhibition in clinical cancer prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336575&form=6&db=m Celecoxib: a new option in the treatment of arthropathies and familial adenomatous polyposis. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11367984&form=6&db=m [Effect of celecoxib, a COX-2 inhibitor, in familial adenomatous polyposis] ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11429490&form=6&db=m Chemoprevention of colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11495083&form=6&db=m Enhanced cyclooxygenase-2 expression in sporadic and familial adenomatous polyposis of the human colon. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566043&form=6&db=m COX-2 inhibition and prevention of cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11606502&form=6&db=m Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11685545&form=6&db=m Mucosal prostanoid receptors and synthesis in familial adenomatous polyposis. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779086&form=6&db=m Approach to angiogenesis inhibition based on cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11945149&form=6&db=m COX selectivity and animal models for colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992750&form=6&db=m Screening for colon cancer and evaluation of chemoprevention with coxibs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12010890&form=6&db=m A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12014863&form=6&db=m Celecoxib with chemotherapy in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12031082&form=6&db=m Size-dependent expression of cyclooxygenase-2 in sporadic colorectal adenomas relative to adenomas in patients with familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075826&form=6&db=m Studies on the development of colon-targeted delivery systems for celecoxib in the prevention of colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102579&form=6&db=m Current application of selective COX-2 inhibitors in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12127122&form=6&db=m Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12145422&form=6&db=m Chemoprevention in colorectal neoplasias: what is practical and feasible? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12151354&form=6&db=m The role of cyclooxygenase-2 (COX-2) in two different morphological stages of intestinal polyps in APC(Delta474) knockout mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12174906&form=6&db=m Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12394442&form=6&db=m Effect of sulindac treatment for attenuated familial adenomatous polyposis with a new germline APC mutation at codon 161: report of a case. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432918&form=6&db=m Cyclooxygenases and colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460897&form=6&db=m Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12491803&form=6&db=m [COX inhibitor, suppression of polyposis, and chemoprevention] causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523457&form=6&db=m Selective cyclooxygenase-2 inhibition: a target in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559775&form=6&db=m Cyclooxygenase 2: a molecular target for cancer prevention and treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12774242&form=6&db=m Cyclo-oxygenase 2 inhibitors: emerging roles in the gut. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12802790&form=6&db=m Cyclooxygenase-2 inhibitors in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810453&form=6&db=m Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941808&form=6&db=m Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14506383&form=6&db=m Cyclo-oxygenase inhibition in colorectal adenomas and cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14508092&form=6&db=m Chemoprevention strategies using NSAIDs and COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14565811&form=6&db=m Use of NSAIDs for the chemoprevention of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14581346&form=6&db=m A randomized, double-blind, placebo-controlled trial of the effects of rofecoxib, a selective cyclooxygenase-2 inhibitor, on rectal polyps in familial adenomatous polyposis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14585257&form=6&db=m Hereditary nonpolyposis colorectal cancer: preventive management. therapeutic application,unassigned 4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623549&form=6&db=m Cyclooxygenase-2 and chemoprevention of breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14649330&form=6&db=m Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and reality. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726667&form=6&db=m Effects of a selective cyclooxygenase-2 inhibitor on cancer cells in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729583&form=6&db=m Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14986031&form=6&db=m E-cadherin expression is homogeneously reduced in adenoma from patients with familial adenomatous polyposis: an immunohistochemical study of E-cadherin, beta-catenin and cyclooxygenase-2 expression. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991580&form=6&db=m Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15000150&form=6&db=m Role of cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15027493&form=6&db=m Cyclooxygenase 2: from inflammation to carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15041464&form=6&db=m Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15119114&form=6&db=m [Chemoprevention of colorectal cancer] causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150127&form=6&db=m Combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor (celecoxib) elicits antitumor immunity and long-term survival in CEA.Tg/MIN mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15188000&form=6&db=m Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239335&form=6&db=m [Cyclooxygenase 2 inhibitors and adenomatous polyposis coli] therapeutic application,unassigned 4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252926&form=6&db=m COX-2 inhibition and colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15309515&form=6&db=m Prevention of colorectal cancer through the use of COX-2 selective inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313405&form=6&db=m Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332534&form=6&db=m [COX and study of cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15353307&form=6&db=m Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15505432&form=6&db=m [Cyclooxygenase-2 expression according to size and location of gastric and colorectal tubular adenomas] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716238&form=6&db=m Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899631&form=6&db=m [Cyclooxygenase 2 inhibitors and adenomatous polyposis coli] therapeutic application,unassigned 4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911099&form=6&db=m Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930344&form=6&db=m Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16042585&form=6&db=m Is COX-2 a 'collateral' target in cancer prevention? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16093206&form=6&db=m Enhanced in vitro percutaneous absorption and in vivo anti-inflammatory effect of a selective cyclooxygenase inhibitor using microemulsion. therapeutic application,unassigned 4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16100520&form=6&db=m Potential use of COX-2-aromatase inhibitor combinations in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219637&form=6&db=m Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16353145&form=6&db=m Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16412030&form=6&db=m Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622748&form=6&db=m Does a selective cyclooxygenase-2 inhibitor (tiracoxib) induce clinically sufficient suppression of adenomas in patients with familial adenomatous polyposis? A randomized double-blind placebo-controlled clinical trial. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16688727&form=6&db=m Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699180&form=6&db=m The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16943400&form=6&db=m Celecoxib for the prevention of sporadic colorectal adenomas. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17164142&form=6&db=m The role of cyclooxygenase-2 and prostaglandins in colon cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17415806&form=6&db=m Cyclooxygenase inhibitors in the chemoprevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17673467&form=6&db=m Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785554&form=6&db=m Cyclooxygenase-2 and platelet-derived growth factor receptors as potential targets in treating aggressive fibromatosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094611&form=6&db=m Increased expression of cytoplasmic HuR in familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18547544&form=6&db=m The anti-proliferative potency of celecoxib is not a class effect of coxibs. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19005184&form=6&db=m Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19035518&form=6&db=m Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19124115&form=6&db=m Increased cyclooxygenase-2 expression in juvenile polyposis syndrome. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19369517&form=6&db=m Host Wnt/{beta}-catenin pathway triggered by Helicobacter pylori correlates with regression of gastric intestinal metaplasia after H. pylori eradication. diagnostic usage,unassigned 3,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19451089&form=6&db=m Label-free global serum proteomic profiling reveals novel celecoxib-modulated proteins in familial adenomatous polyposis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,3
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19544971&form=6&db=m COX-2 polymorphisms in patients with familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895739&form=6&db=m [Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20225762&form=6&db=m Na(+)-stimulated Na+/H+ exchange and an unfavorable Ca2+ homeostasis initiate the cycloxygenase-2 inhibitors-induced apoptotic signals in colonic epithelial cells during the early stage of colon carcinogenesis. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20337729&form=6&db=m Association of circulating tumor cells with tumor-related methylated DNA in patients with hormone-refractory prostate cancer. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21052495&form=6&db=m Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21487015&form=6&db=m Adenomatous polyposis coli protein associates with C/EBP beta and increases Bacillus anthracis edema toxin-stimulated gene expression in macrophages. unassigned -
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21730361&form=6&db=m COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21734388&form=6&db=m Colon cancer: a civilization disorder. causal interaction,unassigned 4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21765608&form=6&db=m Prebiotic treatment reduced preneoplastic lesions through the downregulation of toll like receptor 4 in a chemo-induced carcinogenic model. ongoing research,unassigned 3,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23974731&form=6&db=m Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27072264&form=6&db=m Expression of COX-2 and p53 in juvenile polyposis coli and its correlation with adenomatous changes. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28940183&form=6&db=m An increased CD25-positive intestinal regulatory T-lymphocyte population is dependent on Cox-2 activity in the Apc (Min/+) model. causal interaction,unassigned 1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29109117&form=6&db=m Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29350052&form=6&db=m Protective mechanisms of 6-gingerol in dextran sulfate sodium-induced chronic ulcerative colitis in mice. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33579312&form=6&db=m Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9820411&form=6&db=m Rectal cancer after sulindac therapy for a sporadic adenomatous colonic polyp. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449029&form=6&db=m Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710483&form=6&db=m COX-2 and colon cancer: Potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762021&form=6&db=m COX-2 and colon cancer: potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292836&form=6&db=m Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11793634&form=6&db=m Celecoxib as adjunctive therapy for treatment of colorectal cancer. therapeutic application,unassigned 1,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15167166&form=6&db=m The relationship between cyclooxygenase-2 expression and characteristics of malignant transformation in human colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15525649&form=6&db=m Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716238&form=6&db=m Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685273&form=6&db=m Prostaglandin E(2) stimulates progression-related gene expression in early colorectal adenoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16943401&form=6&db=m Celecoxib for the prevention of colorectal adenomatous polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17278192&form=6&db=m Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17876541&form=6&db=m Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17923032&form=6&db=m [Selective cyclooxygenase-2 inhibitors for the prevention of colorectal adenomas: a meta-analysis] causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18214062&form=6&db=m hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462368&form=6&db=m COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19119558&form=6&db=m Colorectal cancer: a summary of the evidence for screening and prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19413182&form=6&db=m Non-steroidal anti-inflammatory drugs and the risk of cardiovascular diseases: are we going to see the revival of cyclooxygenase-2 selective inhibitors? causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21764857&form=6&db=m Non-Steroidal Anti-inflammatory Drug Use and Risk of Adenomatous and Hyperplastic Polyps. therapeutic application,unassigned 2,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22015819&form=6&db=m COX-derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27432344&form=6&db=m Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29763272&form=6&db=m Colorectal Cancer Screening and Prevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomatous Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34314467&form=6&db=m Cyclooxygenase-2 expression in colorectal carcinoma, adenomatous polyps and non-tumour bearing margins of resection tissues in a cohort of black Africans. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1695815&form=6&db=m Immunohistochemical localization of prostaglandin H synthase in the female reproductive tract and endometriosis. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11228229&form=6&db=m Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17135033&form=6&db=m Effect of the menstrual cycle and oral contraceptives on aromatase and cyclooxygenase-2 expression in adenomyosis. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17354612&form=6&db=m Cyclooxygenase-2 (COX-2) expression in human endometrial carcinoma and precursor lesions and its possible use in cancer chemoprevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584489&form=6&db=m Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19188819&form=6&db=m Expression of Cyclooxygenase-2 and Matrix Metalloproteinase-2 in Adenomyosis and Endometrial Polyps and its Correlation With Angiogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227073&form=6&db=m Suppression of migratory/invasive ability and induction of apoptosis in adenomyosis-derived mesenchymal stem cells by cyclooxygenase-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21573795&form=6&db=m The cancer marker neutrophil gelatinase-associated lipocalin is highly expressed in human endometrial hyperplasia. causal interaction,unassigned 3,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22532781&form=6&db=m Effect of a hormone-releasing intrauterine system (Mirena(®)) on aromatase and Cox-2 expression in patients with adenomyosis submitted or not, to endometrial resection. unassigned -
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23788841&form=6&db=m The effect of oral contraceptives on aromatase and Cox-2 expression in the endometrium of patients with idiopathic menorrhagia or adenomyosis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26054111&form=6&db=m Genetic variation in COX-2 -1195 and the risk of endometriosis and adenomyosis. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28389633&form=6&db=m Leonurine Attenuates Hyperalgesia in Mice with Induced Adenomyosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30387822&form=6&db=m Correlation of LOX?5 and COX?2 expression with inflammatory pathology and clinical features of adenomyosis. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32266025&form=6&db=m Celecoxib, a selective COX-2 inhibitor, markedly reduced the severity of tamoxifen-induced adenomyosis in a murine model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Adenomyosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34017449&form=6&db=m Celecoxib reduces inflammation and angiogenesis in mice with adenomyosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Adenosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605037&form=6&db=m Cyclooxygenase-2 expression in malignant mesenchymal tumors and related uterine lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Adenoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338835&form=6&db=m The cyclo-oxygenase 2 promoter is induced in nontarget cells following adenovirus infection, but an AU-rich 3'-untranslated region destabilization element can increase specificity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Adrenoleukodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2125233&form=6&db=m Arachidonic acid metabolism in fibroblasts from patients with peroxisomal diseases: response to interleukin 1. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Adrenoleukodystrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8261630&form=6&db=m Cyclooxygenase pathway in dermal fibroblasts from patients with metabolic disorders of peroxisomal origin. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 African Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471864&form=6&db=m The viral protein A238L inhibits cyclooxygenase-2 expression through a nuclear factor of activated T cell-dependent transactivation pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Aggressive Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17335379&form=6&db=m Effect of a cyclooxygenase-2 inhibitor on interleukin-1beta-stimulated activation of the transcription factor nuclear factor-kappa B in human gingival fibroblasts. unassigned -
1.14.99.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=103067&form=6&db=m Analgesic sensitivity in children with asthma. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2502051&form=6&db=m The role of cyclooxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6842792&form=6&db=m Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy. unassigned -
1.14.99.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8246133&form=6&db=m Bronchopulmonary actions of 1-(1,2,3,4-tetrahydro-1-naphthylenyl)-1H-imidazole, nitric acid salt (LY150310), a substituted imidazole, in the guinea pig. unassigned -
1.14.99.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788138&form=6&db=m Eicosanoids modulate hyperpnea-induced late phase airway obstruction and hyperreactivity in dogs. therapeutic application,unassigned 3,0
1.14.99.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15949313&form=6&db=m [Expressions of cyclooxygenase-2 and matrix metalloproteinase-2 and airflow obstruction in patients with chronic obstructive pulmonary disease] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Airway Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26761722&form=6&db=m Intranasal curcumin ameliorates airway inflammation and obstruction by regulating MAPKinase activation (p38, Erk and JNK) and prostaglandin D2 release in murine model of asthma. causal interaction,unassigned 1,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961014&form=6&db=m Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12586211&form=6&db=m Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27). causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075190&form=6&db=m Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory. causal interaction,unassigned 1,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15340111&form=6&db=m Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890881&form=6&db=m Puromycin Induces Reversible Proteinuric Injury in Transgenic Mice Expressing Cyclooxygenase-2 in Podocytes. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20671216&form=6&db=m A maladaptive role for EP4 receptors in podocytes. causal interaction,unassigned 4,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21441310&form=6&db=m RENAL PROTECTIVE EFFECT OF CHRONIC INHIBITION OF COX-2 WITH SC58236 IN STREPTOZOTOCIN-DIABETIC RATS. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21737546&form=6&db=m Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22688335&form=6&db=m Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24918154&form=6&db=m Albumin-induced podocyte injury and protection are associated with regulation of COX-2. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26995650&form=6&db=m PGE2 receptor EP3 inhibits water reabsorption and contributes to polyuria and kidney injury in a streptozotocin-induced mouse model of diabetes. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27100703&form=6&db=m Interaction of the renin angiotensin and cox systems in the kidney. causal interaction,unassigned 4,0
1.14.99.1 Albuminuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29425800&form=6&db=m Influence of the selective COX-2 inhibitor celecoxib on sex differences in blood pressure and albuminuria in spontaneously hypertensive rats. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Alkalosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159036&form=6&db=m Multiple Ca(2+)-dependent modulators mediate alkalosis-induced vasodilation in newborn piglet lungs. therapeutic application,unassigned 1,0
1.14.99.1 Alkalosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26536471&form=6&db=m Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials. therapeutic application,unassigned 3,0
1.14.99.1 Alopecia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11980643&form=6&db=m Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Alopecia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14632179&form=6&db=m Expression of cyclooxygenase isozymes during morphogenesis and cycling of pelage hair follicles in mouse skin: precocious onset of the first catagen phase and alopecia upon cyclooxygenase-2 overexpression. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Alopecia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22440736&form=6&db=m Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. ongoing research,unassigned 2,0
1.14.99.1 Altitude Sickness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3521277&form=6&db=m The effect of naproxen on acute mountain sickness and vascular responses to hypoxia. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Altitude Sickness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30476507&form=6&db=m Distinct influence of COX-1 and COX-2 on neuroinflammatory response and associated cognitive deficits during high altitude hypoxia. therapeutic application,unassigned 1,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1608034&form=6&db=m Effects of NSAIDs on beagle crevicular cyclooxygenase metabolites and periodontal bone loss. ongoing research,unassigned 3,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10914805&form=6&db=m Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12005261&form=6&db=m Evidence for the expression of cyclooxygenase-2 enzyme in periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12296588&form=6&db=m Effect of selective cyclooxygenase-2 inhibition on the development of ligature-induced periodontitis in rats. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15853965&form=6&db=m Protective effects of etoricoxib, a selective inhibitor of cyclooxygenase-2, in experimental periodontitis in rats. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16229354&form=6&db=m Selective cyclooxygenase-2 inhibition prevents bone resorption. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18431039&form=6&db=m Pharmacological topics of bone metabolism: a novel bisphosphonate for the treatment of periodontitis. therapeutic application,unassigned 1,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18533784&form=6&db=m COX-2 inhibition decreases VEGF expression and alveolar bone loss during the progression of experimental periodontitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19210344&form=6&db=m Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24130702&form=6&db=m Atorvastatin decreases bone loss, inflammation and oxidative stress in experimental periodontitis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24744546&form=6&db=m Comparative evaluation of the efficacy of the cyclooxygenase pathway inhibitor and nitric oxide synthase inhibitor in the reduction of alveolar bone loss in ligature induced periodontitis in rats: An experimental study. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25929709&form=6&db=m Orthodontic forces add to nicotine-induced loss of periodontal bone : An in vivo and in vitro study. ongoing research,unassigned 3,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26205746&form=6&db=m Exenatide and Sitagliptin Decrease Interleukin 1?, Matrix Metalloproteinase 9, and Nitric Oxide Synthase 2 Gene Expression But Does Not Reduce Alveolar Bone Loss in Rats With Periodontitis. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27725865&form=6&db=m Follicle-stimulating hormone enhances alveolar bone resorption via upregulation of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29335154&form=6&db=m Local administration of Tiludronic Acid downregulates important mediators involved in periodontal tissue destruction in experimental periodontitis in rats. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30970055&form=6&db=m Effects of Selective Versus Non-Selective COX-2 Inhibition on Experimental Periodontitis. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31682614&form=6&db=m Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats. unassigned -
1.14.99.1 Alveolar Bone Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640491&form=6&db=m Effect of environmental tobacco smoke on COX-2 and SHP-2 expression in a periodontitis rat model. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8892355&form=6&db=m Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9168834&form=6&db=m Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9321949&form=6&db=m Decreased expression of prostaglandin G/H synthase-2 (PGHS-2) in Alzheimer's disease brain. causal interaction,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9561129&form=6&db=m Glial and neuronal expression of cyclooxygenase-2: relevance to Alzheimer's disease. diagnostic usage,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9561441&form=6&db=m Mechanism of action of antiinflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9597150&form=6&db=m Cyclooxygenases 1 and 2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726429&form=6&db=m Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9740394&form=6&db=m Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9778144&form=6&db=m Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831328&form=6&db=m Anti-inflammatory drugs and their mechanism of action. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10193997&form=6&db=m Role of cyclooxygenase-1 and -2 in health and disease. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10225537&form=6&db=m Specific COX-2 inhibitors in arthritis, oncology, and beyond: where is the science headed? causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10366679&form=6&db=m Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390128&form=6&db=m The clinical potential of cyclooxygenase-2-specific inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10412020&form=6&db=m Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10560656&form=6&db=m Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons. therapeutic application,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10701410&form=6&db=m [Non-steroidal anti-inflammatory drugs with selectivity for cyclooxygenase-2 in Alzheimer's disease. Rationale and perspectives] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10886331&form=6&db=m Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10933512&form=6&db=m Cyclo-oxygenase-2 inhibitors: rationale and therapeutic potential for Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11028754&form=6&db=m Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032891&form=6&db=m Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11109595&form=6&db=m [Non-steroidal anti-inflammatory agents with selective inhibitory activity on cyclooxygenase-2. Interest and future prospects] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11139808&form=6&db=m COX-2 and Alzheimer's disease: potential roles in inflammation and neurodegeneration. causal interaction,unassigned 2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158633&form=6&db=m Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181073&form=6&db=m Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11193162&form=6&db=m Regulation of APP synthesis and secretion by neuroimmunophilin ligands and cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11194936&form=6&db=m Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain. diagnostic usage,unassigned 2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11203433&form=6&db=m Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders. therapeutic application,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11250126&form=6&db=m Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11255454&form=6&db=m Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311743&form=6&db=m Cyclooxygenase inhibitors--current status and future prospects. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336563&form=6&db=m Anti-inflammatory drugs, cyclooxygenases and other factors. therapeutic application,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11461718&form=6&db=m Cyclooxygenase and Alzheimer's disease: implications for preventive initiatives to slow the progression of clinical dementia. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11503270&form=6&db=m [Clinical application of cyclooxygenase-2 inhibitors] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11580300&form=6&db=m Clinical potential of cyclo-oxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11588192&form=6&db=m Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11739606&form=6&db=m Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11754989&form=6&db=m Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11810182&form=6&db=m Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11909558&form=6&db=m Cardiovascular pharmacology of nonselective nonsteroidal anti-inflammatory drugs and coxibs: clinical considerations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959394&form=6&db=m Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992749&form=6&db=m Evaluation of selective COX-2 inhibitors for the treatment of Alzheimer's disease. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12039862&form=6&db=m Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease. ongoing research,unassigned 2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12050157&form=6&db=m Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells. unassigned -
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204482&form=6&db=m Pain management and beyond: evolving concepts and treatments involving cyclooxygenase inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12358806&form=6&db=m Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432919&form=6&db=m Prostaglandins and other lipid mediators in Alzheimer's disease. causal interaction,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12446975&form=6&db=m From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs and cyclooxygenase in beta-amyloidosis and clinical dementia. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12450219&form=6&db=m Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12566930&form=6&db=m Cyclooxygenase as a target for the antiamyloidogenic activities of nonsteroidal anti-inflammatory drugs in Alzheimer's disease. therapeutic application,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12654342&form=6&db=m The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12770691&form=6&db=m Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12866660&form=6&db=m Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12868200&form=6&db=m [Coxibs: highly selective cyclooxygenase-2 inhibitors. Part I. Clinical efficacy] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12879127&form=6&db=m Defining the role of COX-2 inhibitors in inflammatory and other diseases. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12906745&form=6&db=m Rofecoxib: an update on physicochemical, pharmaceutical, pharmacodynamic and pharmacokinetic aspects. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12973428&form=6&db=m Nonsteroidal antiinflammatory agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12973431&form=6&db=m Clinical aspects of COX-2 inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14507922&form=6&db=m Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530489&form=6&db=m Synthesis and in vivo evaluation of 18F-desbromo-DuP-697 as a PET tracer for cyclooxygenase-2 expression. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552702&form=6&db=m Experimental brain inflammation and neurodegeneration as model of Alzheimer's disease: protective effects of selective COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14724276&form=6&db=m Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. causal interaction,unassigned 2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15032641&form=6&db=m Novel non-steroidal anti-inflammatory drugs: what we have learned from animal studies. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15033806&form=6&db=m Induction of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma during nitric oxide-induced apoptotic PC12 cell death. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15056456&form=6&db=m Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15268640&form=6&db=m COX-2 inhibitors as adjunctive therapy in schizophrenia. therapeutic application,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15276698&form=6&db=m Neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, in the hippocampus of patients with schizophrenia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15317910&form=6&db=m Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. causal interaction,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15551192&form=6&db=m Psychotropic effects of COX-2 inhibitors--a possible new approach for the treatment of psychiatric disorders. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15579005&form=6&db=m Novel insights and therapeutical applications in the field of inhibitors of COX-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15579461&form=6&db=m Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. therapeutic application,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15742005&form=6&db=m A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. causal interaction,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15850674&form=6&db=m New insights into COX-2 biology and inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15912886&form=6&db=m Cyclooxygenase-dependent lipid-modification of brain proteins. causal interaction,unassigned 1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944180&form=6&db=m Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15951464&form=6&db=m The cardiovascular toxicity of selective and nonselective cyclooxygenase inhibitors: comparisons, contrasts, and aspirin confounding. therapeutic application,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15975032&form=6&db=m The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15989624&form=6&db=m Selective cyclooxygenase-2 inhibitors: pharmacology, clinical effects and therapeutic potential. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15991989&form=6&db=m The potential application of cyclo-oxygenase type 2 inhibitors to Alzheimer's disease. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127636&form=6&db=m COX-2 inhibitors--IBC conference. 12-13 April 1999, Coronado, CA, USA. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16134939&form=6&db=m Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. causal interaction,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16223958&form=6&db=m Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16300681&form=6&db=m Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309832&form=6&db=m The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16331303&form=6&db=m Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16402109&form=6&db=m The role of inflammation in CNS injury and disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16406345&form=6&db=m Phospholipase A2 is involved in muscarinic receptor-mediated sAPPalpha release independently of cyclooxygenase or lypoxygenase activity in SH-SY5Y cells. ongoing research,unassigned 1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16478285&form=6&db=m Is there a Future for Cyclo-Oxygenase Inhibitors in Alzheimer's Disease? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16529823&form=6&db=m Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16546299&form=6&db=m Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes. causal interaction,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16753269&form=6&db=m Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. ongoing research,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17027965&form=6&db=m Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17068392&form=6&db=m Long-term efficacy and safety of celecoxib in Alzheimer's disease. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17073683&form=6&db=m Imaging of cyclooxygenase-2 (COX-2) expression: potential use in diagnosis and drug evaluation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17111043&form=6&db=m Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT). ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234302&form=6&db=m Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17457030&form=6&db=m Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612048&form=6&db=m Role of COX-2 in inflammatory and degenerative brain diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18085997&form=6&db=m Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18195459&form=6&db=m Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18254804&form=6&db=m Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537664&form=6&db=m Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537667&form=6&db=m Cyclooxygenase-2 in synaptic signaling. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19447162&form=6&db=m Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664621&form=6&db=m Microsomal prostaglandin E synthase-2: Cellular distribution and expression in Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19893172&form=6&db=m Role of Cyclooxygenase-2 and 5-Lipoxygenase Polymorphisms in Alzheimer's Disease in a Population from Northern Italy: Implication for Pharmacogenomics. unassigned -
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110601&form=6&db=m Role of cyclooxygenase-2 and 5-lipoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy: implication for pharmacogenomics. unassigned -
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20166930&form=6&db=m Progress in COX-2 inhibitors: a journey so far. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20206264&form=6&db=m Thinking outside the box about COX-1 in Alzheimer's disease. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20454929&form=6&db=m Peripheral inflammatory biomarkers of Alzheimer's disease: the role of platelets. causal interaction,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20549385&form=6&db=m Cyclooxygenase (COX)-1 Activity Precedes the COX-2 Induction in Abeta-Induced Neuroinflammation. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20693654&form=6&db=m Neuroinflammation in Alzheimer's Disease: Are NSAIDs and Selective COX-2 Inhibitors the Next Line of Therapy? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20808133&form=6&db=m Association study of interferon-?, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20845789&form=6&db=m [Effects of Valeriana amurensis on the expressions of iNOS, COX-2 and IkappaCB-alpha in Alzheimer's disease model rat's brain] diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20847443&form=6&db=m Amyloid-? Induces Cyclooxygenase-2 and PGE2 Release in Human Astrocytes in NF-? B Dependent Manner. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21278785&form=6&db=m Evodiamine improves congnitive abilities in SAMP8 and APP(swe)/PS1(?E9) transgenic mouse models of Alzheimer's disease. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21504126&form=6&db=m Neuroinflammation in Alzheimer's disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21701788&form=6&db=m Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer's Disease in Rats. causal interaction,unassigned 2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22617488&form=6&db=m Oligomers of ?-amyloid protein (A?1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1?, tumour necrosis factor-?, and a nuclear factor ?-B mechanism in the rat brain. causal interaction,unassigned 1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22622868&form=6&db=m Association study of polymorphisms in the cyclooxygenase-2 gene and Alzheimer's disease risk in Chinese. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22766501&form=6&db=m Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of ?-amyloid peptide fragment 31-35. therapeutic application,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23083210&form=6&db=m Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23553915&form=6&db=m Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059237&form=6&db=m Radiotracers for Molecular Imaging of Cyclooxygenase-2 (COX-2) Enzyme. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24250402&form=6&db=m Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24267894&form=6&db=m ?9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. causal interaction,unassigned 1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25624863&form=6&db=m Association study of COX-2 (PTGS2) -765 G/C promoter polymorphism by pyrosequencing in Sicilian patients with Alzheimer's disease. ongoing research,unassigned 1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25690564&form=6&db=m Design, Synthesis and In Vitro Study of 5,6-Diaryl-1,2,4-triazine-3-ylthioacetate Derivatives as COX-2 and ?-Amyloid Aggregation Inhibitors. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328537&form=6&db=m Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26521945&form=6&db=m Eicosanoids Derived From Arachidonic Acid and Their Family Prostaglandins and Cyclooxygenase in Psychiatric Disorders. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585055&form=6&db=m Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer's Disease Model Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26671095&form=6&db=m Cyclooxygenase-2 gene polymorphisms and risk of Alzheimer's disease: A meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26748744&form=6&db=m Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26857505&form=6&db=m Role of cox-2 mediated neuroinflammation on the neurodegeneration and cognitive impairments in colchicine induced rat model of Alzheimer's Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26869183&form=6&db=m Prostaglandin I2 Attenuates Prostaglandin E2-Stimulated Expression of Interferon ? in a ?-Amyloid Protein- and NF-?B-Dependent Mechanism. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26880859&form=6&db=m Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041861&form=6&db=m Naringin and Rutin Alleviates Episodic Memory Deficits in Two Differentially Challenged Object Recognition Tasks. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27190010&form=6&db=m Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27215623&form=6&db=m Influence of four polymorphisms in ABCA1 and PTGS2 genes on risk of Alzheimer's disease: a meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27240539&form=6&db=m Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1? and anterior pharynx-defective-1? in amyloid precursor protein/presenilin 1 transgenic mice. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27443496&form=6&db=m Meta-analysis of cyclooxygenase-2 (COX-2) 765G>C polymorphism and Alzheimer's disease. causal interaction,unassigned 2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28413375&form=6&db=m Inflammatory Cyclooxygenase Activity and PGE2 Signaling in Models of Alzheimer's Disease. unassigned -
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28588301&form=6&db=m Protective effects of gingerol on streptozotocin-induced sporadic Alzheimer's disease: emphasis on inhibition of ?-amyloid, COX-2, alpha-, beta - secretases and APH1a. ongoing research,unassigned 2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28979299&form=6&db=m Physicochemical, Stress Degradation Evaluation and Pharmacokinetic Study of AZGH102, a New Synthesized COX2 Inhibitors after I.V. and Oral Administration in Male and Female Rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262525&form=6&db=m Prostaglandin I causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29674956&form=6&db=m miR-103 Promotes Neurite Outgrowth and Suppresses Cells Apoptosis by Targeting Prostaglandin-Endoperoxide Synthase 2 in Cellular Models of Alzheimer's Disease. ongoing research,unassigned 1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29777723&form=6&db=m Effect of acetylcholinesterase inhibitors donepezil and rivastigmine on the activity and expression of cyclooxygenases in a model of the inflammatory action of fluoride on macrophages obtained from THP-1 monocytes. therapeutic application,unassigned 1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30020833&form=6&db=m Integrated communications between cyclooxygenase-2 and Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30475154&form=6&db=m Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells. unassigned -
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30771604&form=6&db=m Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase. therapeutic application,unassigned 3,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31345147&form=6&db=m Long non-coding RNA MALAT1 Inhibits Neuron Apoptosis and Neuroinflammation while Stimulates Neurite Outgrowth and its Correlation with MiR-125b Mediated PTGS2, CDK5 and FOXQ1 in Alzheimer's Disease. unassigned -
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31392591&form=6&db=m Cyclooxygenase-2 Induced the ?-Amyloid Protein Deposition and Neuronal Apoptosis Via Upregulating the Synthesis of Prostaglandin E2 and 15-Deoxy-?12,14-prostaglandin J2. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31512661&form=6&db=m Cyclooxygenase-2 Gene Polymorphisms and Risk of Alzheimer's Disease: A Possible Biomoleular Explanation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31551514&form=6&db=m Cyclooxygenase-2 is critical for the propagation of ?-amyloid protein and reducing the glycosylation of tau in Alzheimer's disease. unassigned -
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31861093&form=6&db=m A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer's Disease. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32141867&form=6&db=m ENDOCANNABINOIDS RECEPTORS MEDIATED CENTRAL AND PERIPHERAL EFFECTS (REVIEW). causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742252&form=6&db=m Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer's Disease. causal interaction,unassigned 2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33042470&form=6&db=m Long noncoding RNA MALAT1 and its target microRNA-125b are potential biomarkers for Alzheimer's disease management via interactions with FOXQ1, PTGS2 and CDK5. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33095414&form=6&db=m Prostaglandin A1 Decreases the Phosphorylation of Tau by Activating Protein Phosphatase 2A via a Michael Addition Mechanism at Cysteine 377. causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33408612&form=6&db=m Targeting MicroRNA-125b Promotes Neurite Outgrowth but Represses Cell Apoptosis and Inflammation via Blocking PTGS2 and CDK5 in a FOXQ1-Dependent Way in Alzheimer Disease. ongoing research,unassigned 2,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33889764&form=6&db=m Pharmacophore model, docking, QSAR, and molecular dynamics simulation studies of substituted cyclic imides and herbal medicines as COX-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34346520&form=6&db=m Is cyclooxygenase-1 involved in neuroinflammation? causal interaction,unassigned 4,0
1.14.99.1 Alzheimer Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34347557&form=6&db=m The effect of vitamin B12 on synaptic plasticity of hippocampus in Alzheimer's disease model rats. causal interaction,unassigned 3,0
1.14.99.1 Ameloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26005470&form=6&db=m Immunohistochemical analysis of COX-2 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma: A comparative study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Ameloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123497&form=6&db=m Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Ameloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29559247&form=6&db=m COX-2 as a determinant of lower disease-free survival for patients affected by ameloblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Ameloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692057&form=6&db=m Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Ameloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34398475&form=6&db=m Cyclooxygenase-2 protein expression modulates cell proliferation and apoptosis in solid ameloblastoma and odontogenic keratocyst. An immunohistochemical study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12044481&form=6&db=m The IkappaB kinase inhibitor sulfasalazine impairs long-term memory in the crab Chasmagnathus. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17937934&form=6&db=m Possible glutamatergic and lipid signalling mechanisms in ECT-induced retrograde amnesia: experimental evidence for involvement of COX-2, and review of literature. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18523723&form=6&db=m Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Amnesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18690928&form=6&db=m The role of the New Zealand Intensive Medicines Monitoring Programme in identification of previously unrecognised signals of adverse drug reactions. therapeutic application,unassigned 1,0
1.14.99.1 Amnesia, Retrograde http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17937934&form=6&db=m Possible glutamatergic and lipid signalling mechanisms in ECT-induced retrograde amnesia: experimental evidence for involvement of COX-2, and review of literature. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Amnesia, Retrograde http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18523723&form=6&db=m Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Amyloidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9987081&form=6&db=m Induction of cyclooxygenase-2 in human synovial cells by beta 2-microglobulin. ongoing research,unassigned 4,0
1.14.99.1 Amyloidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12450219&form=6&db=m Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Amyloidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16756637&form=6&db=m Effect of indomethacin and selective cyclooxygenase-2 inhibitors on proteinuria and renal function in patients with AA type renal amyloidosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11079544&form=6&db=m Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis. therapeutic application,unassigned 1,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11220737&form=6&db=m Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. unassigned -
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12586733&form=6&db=m A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14511332&form=6&db=m Expression and localization of cyclooxygenase-1 and -2 in human sporadic amyotrophic lateral sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14720207&form=6&db=m Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991384&form=6&db=m Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15447673&form=6&db=m Induction of cyclooxygenase-2 in reactive glial cells by the CD40 pathway: relevance to amyotrophic lateral sclerosis. unassigned -
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816863&form=6&db=m Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16184763&form=6&db=m Nonsteroidal anti-inflammatory drugs differentially affect the heat shock response in cultured spinal cord cells. ongoing research,unassigned 2,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16512913&form=6&db=m COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. unassigned -
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619237&form=6&db=m Is prostaglandin E(2) a pathogenic factor in amyotrophic lateral sclerosis? unassigned -
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16802291&form=6&db=m Trial of celecoxib in amyotrophic lateral sclerosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17901552&form=6&db=m Function of COX-2 and prostaglandins in neurological disease. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18414597&form=6&db=m Altered Lipid Metabolism in Brain Injury and Disorders. therapeutic application,unassigned 3,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18751914&form=6&db=m Altered lipid metabolism in brain injury and disorders. therapeutic application,unassigned 3,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328537&form=6&db=m Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903591&form=6&db=m Rofecoxib Attenuates the Pathogenesis of Amyotrophic Lateral Sclerosis by Alleviating Cyclooxygenase-2-Mediated Mechanisms. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Amyotrophic Lateral Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19813&form=6&db=m On the structure of slow reacting substance of anaphylaxis: evidence of biosynthesis from arachidonic acid. causal interaction,unassigned 1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716064&form=6&db=m Leukotrienes, thromboxane A2, and prostaglandins during systemic anaphylaxis in sheep. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2502629&form=6&db=m Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2580036&form=6&db=m Anaphylatoxin C3a enhances mucous glycoprotein release from human airways in vitro. unassigned -
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2813496&form=6&db=m Effects of 5-lipoxygenase inhibition on cardiac anaphylaxis in isolated guinea pig hearts. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3000944&form=6&db=m Eicosanoid modulation of stress fibers in cultured bovine aortic endothelial cells. ongoing research,unassigned 1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3005414&form=6&db=m Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis in guinea pigs pretreated by indomethacin or by a fish oil-enriched diet. unassigned -
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3011947&form=6&db=m Cyclooxygenase blockade elevates leukotriene E4 production during acute anaphylaxis in sheep. unassigned -
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3459725&form=6&db=m Ciliary responsiveness in allergic and nonallergic airways. therapeutic application,unassigned 1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3552581&form=6&db=m Analgesics, allergy and asthma. unassigned -
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3828903&form=6&db=m Mechanisms of response to antigen in isolated guinea pig trachea after active sensitization. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3933389&form=6&db=m Ozone-induced bronchial hyperreactivity in guinea pigs is abolished by BW 755C or FPL 55712 but not by indomethacin. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6200117&form=6&db=m Total profiling by GC/NICIMS of the major cyclo-oxygenase products from antigen and leukotriene-challenged guinea-pig lung. causal interaction,unassigned 3,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6332191&form=6&db=m Effect of C3a and C5a anaphylatoxins on guinea-pig isolated blood vessels. therapeutic application,unassigned 4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6384796&form=6&db=m Effects of exogenous prostaglandins on the release of leukotriene C4-like immunoreactivity and on coronary flow in indomethacin-treated anaphylactic guinea-pig hearts. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6431753&form=6&db=m Bronchial anaphylaxis in actively sensitized Sprague Dawley rats: studies on mediators involved. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6722282&form=6&db=m Quantitative analysis of prostanoids in biological fluids by combined capillary column gas chromatography negative ion chemical ionization mass spectrometry. diagnostic usage,unassigned 4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6795979&form=6&db=m Effect of pharmacologic agents on antigen-induced decreases in specific lung conductance in sheep. therapeutic application,unassigned 1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6813301&form=6&db=m Cyclooxygenase metabolites in human lung anaphylaxis: airway vs. parenchyma. ongoing research,unassigned 4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7282491&form=6&db=m SRS-A mediated bronchospasm by pharmacologic modification of lung anaphylaxis in vivo. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7316107&form=6&db=m Idiosyncrasy to pyrazolone drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7916299&form=6&db=m Involvement of leukotrienes in allergic inflammation in mice. therapeutic application,unassigned 2,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9480933&form=6&db=m Effects of anaphylaxis mediators on partitioned pulmonary vascular resistance during ragweed shock in dogs. therapeutic application,unassigned 1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10508800&form=6&db=m Histamine H3 receptor blockade improves cardiac function in canine anaphylaxis. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10731856&form=6&db=m [Mastocytosis: an important differential diagnosis in anaphylactoid reaction to Hymenoptera sting. A case report and overview of clinical aspects, diagnosis and current therapy of mastocytosis] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752370&form=6&db=m Anaphylactoid reaction to a cyclooxygenase-2 inhibitor in a patient who had a reaction to a cyclooxygenase-1 inhibitor. therapeutic application,unassigned 4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12668894&form=6&db=m Anaphylactic and anaphylactoid reactions to aspirin and other NSAIDs. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14660036&form=6&db=m Biphasic response of cutaneous blood flow induced by passive cutaneous anaphylaxis in rats. therapeutic application,unassigned 1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242723&form=6&db=m Aspirin and NSAID sensitivity. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15521372&form=6&db=m Safety of the new selective cyclooxygenase type 2 inhibitors rofecoxib and celecoxib in patients with anaphylactoid reactions to nonsteroidal anti-inflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17039673&form=6&db=m Meloxicam-associated anaphylactic reaction. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17583106&form=6&db=m Challenge-based clinical patterns of 223 Spanish patients with nonsteroidal anti-inflammatory-drug-induced-reactions. causal interaction,unassigned 1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23442108&form=6&db=m Nitric oxide and ?2-adrenoceptor activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23562928&form=6&db=m Anti-inflammatory activity of hexane extracts from bones and internal organs of Anguilla japonica suppresses cyclooxygenase-2-dependent prostaglandin D? generation in mast cells and anaphylaxis in mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25907560&form=6&db=m MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells. causal interaction,unassigned 4,0
1.14.99.1 Anaphylaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27017914&form=6&db=m Nonsteroidal anti-inflammatory drugs enhance IgE-mediated activation of human basophils in patients with food anaphylaxis dependent and independent of nonsteroidal anti-inflammatory drugs. unassigned -
1.14.99.1 Anaplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502795&form=6&db=m Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517490&form=6&db=m Cyclooxygenase-2 is essential for normal recovery from 5-fluorouracil-induced myelotoxicity in mice. causal interaction,unassigned 3,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12312741&form=6&db=m Prevention of iron deficiency anemia in IUD users by prostaglandin synthetase inhibitors. causal interaction,unassigned 2,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529405&form=6&db=m Clinical implications of COX-1 and/or COX-2 inhibition for the distal gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809915&form=6&db=m Impaired systemic production of prostaglandin E2 in children with cerebral malaria. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18031539&form=6&db=m Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18797164&form=6&db=m Effect of Exercise on Cardiac Tissue Oxidative and Inflammatory Mediators in Chronic Kidney Disease. ongoing research,unassigned 1,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22730036&form=6&db=m Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743193&form=6&db=m Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26182160&form=6&db=m Effect of the misoprostol-rebamipide combination on iron deficiency anemia in patients under long-term cyclooxygenase-2 selective inhibitor treatment for small bowel ulcers. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30111424&form=6&db=m [Expression of COX-1 and COX-2 in the Platelet of Iron Deficiency Anemia Women at Childbearing Age and Its Clinical Significance]. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31664161&form=6&db=m Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Anemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33762373&form=6&db=m Non-steroidal anti-inflammatory drugs and the gastrointestinal tract. therapeutic application,unassigned 4,0
1.14.99.1 Anemia, Hemolytic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15489961&form=6&db=m Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice. therapeutic application,unassigned 1,0
1.14.99.1 Anemia, Iron-Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12312741&form=6&db=m Prevention of iron deficiency anemia in IUD users by prostaglandin synthetase inhibitors. causal interaction,unassigned 2,0
1.14.99.1 Anemia, Iron-Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26182160&form=6&db=m Effect of the misoprostol-rebamipide combination on iron deficiency anemia in patients under long-term cyclooxygenase-2 selective inhibitor treatment for small bowel ulcers. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Anemia, Iron-Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30111424&form=6&db=m [Expression of COX-1 and COX-2 in the Platelet of Iron Deficiency Anemia Women at Childbearing Age and Its Clinical Significance]. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Anemia, Iron-Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33762373&form=6&db=m Non-steroidal anti-inflammatory drugs and the gastrointestinal tract. therapeutic application,unassigned 4,0
1.14.99.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15086495&form=6&db=m Micro-MRI methods to detect renal cysts in mice. ongoing research,unassigned 3,0
1.14.99.1 Anemia, Sickle Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18809239&form=6&db=m Modulation of redox pathways in neutrophils from sickle cell disease patients. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10231640&form=6&db=m Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825178&form=6&db=m Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. causal interaction,unassigned 2,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15770365&form=6&db=m Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16311343&form=6&db=m mRNA expression of genes involved in lipid efflux and matrix degradation in occlusive and ectatic atherosclerotic disease. ongoing research,unassigned 2,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574591&form=6&db=m MF-tricyclic inhibits growth of experimental abdominal aortic aneurysms. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27159620&form=6&db=m Microsomal Prostaglandin E Synthase-1 Expression by Aortic Smooth Muscle Cells Attenuates the Differentiated Phenotype. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27296993&form=6&db=m Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27399380&form=6&db=m Oral Presentations of the 2016 Annual Meeting of the Congress of Neurological Surgeons: San Diego, California: September 24-28, 2016: 100?Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28431181&form=6&db=m Protective Effect of Mesenchymal Stem Cells Against the Development of Intracranial Aneurysm Rupture in Mice. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31860812&form=6&db=m Disruption of P2X4 purinoceptor and suppression of the inflammation associated with cerebral aneurysm formation. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32646326&form=6&db=m Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging. unassigned -
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33226922&form=6&db=m Response by Rodemerk et al to Letter Regarding Article, "Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging". unassigned -
1.14.99.1 Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33226924&form=6&db=m Letter by Wen et al Regarding Article, "Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging". unassigned -
1.14.99.1 Angina, Stable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16890573&form=6&db=m Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1
1.14.99.1 Angina, Stable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323963&form=6&db=m [?ptimization of stable angina standard therapy in patients with concomitant osteoarthritis and obesity]. therapeutic application,unassigned 4,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3111003&form=6&db=m Altered intraplatelet arachidonic acid metabolism during the acute state of unstable angina. causal interaction,unassigned 4,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3248116&form=6&db=m Platelet arachidonic acid metabolism in patients with cardiovascular disorders. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7661062&form=6&db=m Aspirin therapy: optimized platelet inhibition with different loading and maintenance doses. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9286937&form=6&db=m Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10946089&form=6&db=m Transcellular formation of thromboxane A(2) in mixed incubations of endothelial cells and aspirin-treated platelets strongly depends on the prostaglandin I-synthase activity. therapeutic application,unassigned 3,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704783&form=6&db=m How to get from antiplatelet to antithrombotic treatment. therapeutic application,unassigned 1,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12105157&form=6&db=m Efficacy assessment of meloxicam, a preferential cyclooxygenase-2 inhibitor, in acute coronary syndromes without ST-segment elevation: the Nonsteroidal Anti-Inflammatory Drugs in Unstable Angina Treatment-2 (NUT-2) pilot study. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871422&form=6&db=m Identification of differentially expressed genes in coronary atherosclerotic plaques from patients with stable or unstable angina by cDNA array analysis. diagnostic usage,unassigned 1,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14592549&form=6&db=m Aspirin insensitive eicosanoid biosynthesis in cardiovascular disease. therapeutic application,unassigned 1,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15531933&form=6&db=m High-dose statin and COX-2 inhibitor therapy rapidly decreases C-reactive protein level in patients with unstable angina. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16890573&form=6&db=m Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1
1.14.99.1 Angina, Unstable http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19758923&form=6&db=m Effect of early statin and selective cyclooxygenase-2 inhibitor therapy on C-reactive protein level after percutaneous coronary angioplasty in unstable angina. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11570615&form=6&db=m Tolerability to new COX-2 inhibitors in NSAID-sensitive patients with cutaneous reactions. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11708434&form=6&db=m Urticaria and angioedema from cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11842312&form=6&db=m Urticaria and angioedema induced by COX-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12444802&form=6&db=m NSAID-induced urticaria and angioedema: a reappraisal of its clinical management. causal interaction,unassigned 3,0
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12668893&form=6&db=m Cutaneous reactions to aspirin and nonsteroidal antiinflammatory drugs. therapeutic application,unassigned 4,0
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15811906&form=6&db=m Angioedema associated with aspirin and rofecoxib. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136765&form=6&db=m Safety of etoricoxib, a new cyclooxygenase 2 inhibitor, in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291297&form=6&db=m Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug (NSAID) in Japanese patients with NSAID-induced urticaria and/or angioedema: Comparison of meloxicam, etodolac and tiaramide. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21834936&form=6&db=m Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Angioedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25562554&form=6&db=m Management of patients with nonaspirin-exacerbated respiratory disease aspirin hypersensitivity reactions. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Anhedonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20392837&form=6&db=m Sex-Dependent Effects of Neonatal Inflammation on Adult Inflammatory Markers and Behavior. ongoing research,unassigned 4,0
1.14.99.1 Anophthalmos http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33454433&form=6&db=m New insights into the obligatory nature of cyclooxygenase-2 and PGE2 during early chick embryogenesis. therapeutic application,unassigned 1,0
1.14.99.1 Anosmia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28124651&form=6&db=m Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future. diagnostic usage,unassigned 2,0
1.14.99.1 Anthrax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22902502&form=6&db=m Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. ongoing research,unassigned 2,0
1.14.99.1 Anti-Glomerular Basement Membrane Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135071&form=6&db=m Hyaluronan-induced cyclooxygenase-2 expression promotes thromboxane A2 production by renal cells. ongoing research,unassigned 4,0
1.14.99.1 Anuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6772782&form=6&db=m Oligohydramnios and transient neonatal anuria: a possible association with the maternal use of prostaglandin synthetase inhibitors. causal interaction,unassigned 4,0
1.14.99.1 Anuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15786824&form=6&db=m COX-2 inhibitor induced anuric renal failure in a previously healthy young woman. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10231640&form=6&db=m Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4
1.14.99.1 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10731924&form=6&db=m Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825178&form=6&db=m Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. causal interaction,unassigned 2,0
1.14.99.1 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15770365&form=6&db=m Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Aortic Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26798667&form=6&db=m Indomethacin Prevents the Progression of Thoracic Aortic Aneurysm in Marfan Syndrome Mice. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9152308&form=6&db=m Prostaglandin E2 synthesis and cyclooxygenase expression in abdominal aortic aneurysms. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16311343&form=6&db=m mRNA expression of genes involved in lipid efflux and matrix degradation in occlusive and ectatic atherosclerotic disease. ongoing research,unassigned 2,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16514081&form=6&db=m Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17137566&form=6&db=m Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice. causal interaction,unassigned 4,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17349338&form=6&db=m Cyclooxygenase-2 expression and its association with increased angiogenesis in human abdominal aortic aneurysms. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19625268&form=6&db=m The Influence of COX-2 Single Nucleotide Polymorphisms on Abdominal Aortic Aneurysm Development and the Associated Inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22967986&form=6&db=m Effectiveness of Cyclooxygenase-2 Inhibition in Limiting Abdominal Aortic Aneurysm Progression in Mice Correlates with a Differentiated Smooth Muscle Cell Phenotype. causal interaction,unassigned 2,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23209546&form=6&db=m Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27159620&form=6&db=m Microsomal Prostaglandin E Synthase-1 Expression by Aortic Smooth Muscle Cells Attenuates the Differentiated Phenotype. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408196&form=6&db=m Defective p27 phosphorylation at serine 10 affects vascular reactivity and increases abdominal aortic aneurysm development via Cox-2 activation. unassigned -
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31328426&form=6&db=m Regulatory T cells protected against abdominal aortic aneurysm by suppression of the COX-2 expression. ongoing research,unassigned 2,0
1.14.99.1 Aortic Aneurysm, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908926&form=6&db=m Quercetin Downregulates Cyclooxygenase-2 Expression and HIF-1?/VEGF Signaling-Related Angiogenesis in a Mouse Model of Abdominal Aortic Aneurysm. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Aortic Coarctation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8206572&form=6&db=m Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Aortic Coarctation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11065217&form=6&db=m Increased renal vasoconstriction and gene expression of cyclooxygenase-1 in renovascular hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Aortic Valve Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31061914&form=6&db=m Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Aortic Valve Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982687&form=6&db=m Induction of aortic valve calcification by celecoxib and its COX-2 independent derivatives is glucocorticoid-dependent. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Apnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6419199&form=6&db=m A reexamination of the role of oxygen in retrolental fibroplasia. causal interaction,unassigned 3,0
1.14.99.1 Apnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384628&form=6&db=m Role of TRPA1 and TRPV1 in the ROS-dependent sensory irritation of superior laryngeal capsaicin-sensitive afferents by cigarette smoke in anesthetized rats. therapeutic application,unassigned 1,0
1.14.99.1 Appendiceal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28280620&form=6&db=m Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. unassigned -
1.14.99.1 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16968832&form=6&db=m Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arrhythmias, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17469317&form=6&db=m [Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arteriosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15905461&form=6&db=m COX-2-derived prostacyclin modulates vascular remodeling. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arteriosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16274925&form=6&db=m Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens. causal interaction,unassigned 4,0
1.14.99.1 Arteriosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508949&form=6&db=m Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Arteriosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17469317&form=6&db=m [Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arteriosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18452714&form=6&db=m PKC-delta/c-Src-mediated EGF receptor transactivation regulates thrombin-induced COX-2 expression and PGE(2) production in rat vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Arteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31162032&form=6&db=m Cytokine expression in temporal arteries: comparative analysis between patients with biopsy-positive giant cell arteritis, biopsy-negative giant cell arteritis and biopsy-negative without arteritis. diagnostic usage,unassigned 2,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078133&form=6&db=m Cyclooxygenase-2 in synovial tissue and fluid of dysfunctional temporomandibular joints with internal derangement. therapeutic application,unassigned 4,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15337183&form=6&db=m Immunohistochemical localization of cyclooxygenase-1 and -2 in synovial tissues from patients with internal derangement or osteoarthritis of the temporomandibular joint. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16476713&form=6&db=m Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507399&form=6&db=m Taxanes and COX-2 inhibitors: from molecular pathways to clinical practice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594377&form=6&db=m In patients with temporomandibular disorders, do particular interventions influence oral health-related quality of life? A qualitative systematic review of the literature. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18554814&form=6&db=m Effects of celecoxib on ionic currents and spontaneous firing in rat retinal neurons. therapeutic application,unassigned 4,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19014495&form=6&db=m Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19713092&form=6&db=m A randomized double blind comparison of short-term duodenally administrated whale and seal blubber oils in patients with inflammatory bowel disease and joint pain. therapeutic application,unassigned 2,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22641670&form=6&db=m Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29661110&form=6&db=m Alteration of gait parameters in a mouse model of surgically induced knee osteoarthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31360199&form=6&db=m Expression of microRNAs in the plasma of patients with acute gouty arthritis and the effects of colchicine and etoricoxib on the differential expression of microRNAs. unassigned -
1.14.99.1 Arthralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31937359&form=6&db=m Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1729286&form=6&db=m In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2118185&form=6&db=m Synthesis and quantitative structure-activity relationships of diclofenac analogues. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6227748&form=6&db=m Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers. ongoing research,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7473585&form=6&db=m 1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8628978&form=6&db=m Clinical implications of selective cyclooxygenase-2 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647962&form=6&db=m Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8737749&form=6&db=m Nitric oxide enhances cyclooxygenase activity in articular cartilage. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8761181&form=6&db=m Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9154274&form=6&db=m Cyclooxygenase-2 inhibitors: a new approach to the therapy of ocular inflammation. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249646&form=6&db=m COX-1 and COX-2 tissue expression: implications and predictions. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9433877&form=6&db=m Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9561138&form=6&db=m Cyclooxygenase-2 in the spinal cord: localization and regulation after a peripheral inflammatory stimulus. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9628262&form=6&db=m Inhibitory effects of JTE-522, a novel prostaglandin H synthase-2 inhibitor, on adjuvant-induced arthritis and bone changes in rats. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9714356&form=6&db=m Detection of COX-1 and COX-2 isoforms in synovial fluid cells from inflammatory joint diseases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9751091&form=6&db=m Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9793797&form=6&db=m The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis-induced monoarticular arthritis in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9855176&form=6&db=m Future trends in the development of safer nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892042&form=6&db=m Expression of cyclooxygenase isoforms in the rat spinal cord and their regulation during adjuvant-induced arthritis. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10100465&form=6&db=m COX-2 inhibitors. New medication for arthritis pain. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10193996&form=6&db=m The unmet anti-inflammatory needs in orthopedics. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10225537&form=6&db=m Specific COX-2 inhibitors in arthritis, oncology, and beyond: where is the science headed? causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10225538&form=6&db=m Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: what can we expect? therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10405519&form=6&db=m Specific cyclooxygenase-2 (COX-2) inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419773&form=6&db=m The role of COX-2 produced by cartilage in arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419775&form=6&db=m Human chondrocyte culture models for studying cyclooxygenase expression and prostaglandin regulation of collagen gene expression. therapeutic application,unassigned 2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419782&form=6&db=m COX-2 in synovial tissues. causal interaction,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10422541&form=6&db=m Vision of the future in arthritis care. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10422543&form=6&db=m COX-2: separating myth from reality. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10422544&form=6&db=m Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: what can we expect? therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10463513&form=6&db=m Selective cyclooxygenase-2 inhibitors for the treatment of arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10501435&form=6&db=m Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2. therapeutic application,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10643694&form=6&db=m Basic biology and clinical application of specific cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10667323&form=6&db=m Mitigation of arthritis by high-dose administration of a COX-2 inhibitor in the collagen-induced arthritis model in the mouse. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10708568&form=6&db=m Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10868021&form=6&db=m [Cyclooxygenase-2 (Cox-2) selective inhibitors: socioeconomic and pharmaco-epidemiologic aspects] unassigned -
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10882157&form=6&db=m COX-2 selective nonsteroidal anti-Inflammatory drugs: do they really offer any advantages? causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10914694&form=6&db=m COX-2 specific inhibitors in the management of arthritis and pain. Introduction. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10914696&form=6&db=m Use of COX-2 specific inhibitors in operative and nonoperative management of patients with arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10956225&form=6&db=m Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11028754&form=6&db=m Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032098&form=6&db=m Antiinflammatory and analgesic efficacy of COX-2 specific inhibition: from investigational trials to clinical experience. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032965&form=6&db=m Role of cyclooxygenases in angiogenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11067848&form=6&db=m Cloning, expression, and up-regulation of inducible rat prostaglandin e synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11102560&form=6&db=m Clinical experience with specific COX-2 inhibitors in arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11145026&form=6&db=m The genetic ablation of cyclooxygenase 2 prevents the development of autoimmune arthritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11191731&form=6&db=m Visual disturbance associated with celecoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11225347&form=6&db=m The impact of nonsteroidal anti-inflammatory drug-induced gastropathy. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316141&form=6&db=m Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509060&form=6&db=m Risk of cardiovascular events associated with selective COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695246&form=6&db=m What have we learned from the large outcomes trials of COX-2 selective inhibitors? The rheumatologist's perspective. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695247&form=6&db=m NSAIDs and COX-2 inhibitors: what can we learn from large outcomes trials? The gastroenterologist's perspective. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11752357&form=6&db=m Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. therapeutic application,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11772254&form=6&db=m Therapeutic potential of COX-2 inhibitors in arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11805193&form=6&db=m Cyclooxygenase-2--10 years later. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11909558&form=6&db=m Cardiovascular pharmacology of nonselective nonsteroidal anti-inflammatory drugs and coxibs: clinical considerations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11967252&form=6&db=m Effects of celecoxib on ambulatory blood pressure in hypertensive patients on ACE inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11974679&form=6&db=m New COX-2 arthritis drug receives FDA approval. therapeutic application,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11981317&form=6&db=m Specific cyclooxygenase-2 inhibitors: what have we learned since they came into widespread clinical use? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12005203&form=6&db=m Antithrombotic and platelet function inhibiting effects of ML3000, a new antiinflammatory drug with Cox/5-LOX inhibitory activity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12012021&form=6&db=m A new ditriazine inhibitor of NF-kappaB modulates chronic inflammation and angiogenesis. ongoing research,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12013363&form=6&db=m Celecoxib-induced erythema multiforme with glyburide cross-reactivity. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12014863&form=6&db=m Celecoxib with chemotherapy in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020053&form=6&db=m Valdecoxib (Pharmacia). therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075734&form=6&db=m Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086290&form=6&db=m COX-2-selective inhibitors in the treatment of arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086294&form=6&db=m Development and clinical application of COX-2-selective inhibitors for the treatment of osteoarthritis and rheumatoid arthritis. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086298&form=6&db=m Emerging options with coxib therapy. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12144946&form=6&db=m PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12171167&form=6&db=m Effects of anti-arthritis preparations on gene expression and enzyme activity of cyclooxygenase-2 in cultured equine chondrocytes. causal interaction,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12184054&form=6&db=m Mechanisms of progressive renal disease: role of angiotensin II, cyclooxygenase products and nitric oxide. causal interaction,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12241124&form=6&db=m Selective cyclo-oxygenase-2 inhibitors and myocardial infarction: how strong is the link? causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388629&form=6&db=m Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12398962&form=6&db=m Effects of celecoxib and rofecoxib on blood pressure and edema in patients > or =65 years of age with systemic hypertension and osteoarthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12423770&form=6&db=m Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12427705&form=6&db=m The double-edged sword of COX-2 selective NSAIDs. ongoing research,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12472224&form=6&db=m COX-2 selective NSAID decreases bone ingrowth in vivo. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12501222&form=6&db=m Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12508788&form=6&db=m A selective COX-2 inhibitor, meloxicam, as a treatment option in patients with juvenile idiopathic arthritis and gastrointestinal side effects from naproxen. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12629931&form=6&db=m Cyclooxygenase-2: from arthritis treatment to new indications for the prevention and treatment of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12680487&form=6&db=m Valdecoxib-induced toxic epidermal necrolysis in a patient allergic to sulfa drugs. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12707354&form=6&db=m Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711837&form=6&db=m Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12752891&form=6&db=m Evaluation of cyclooxygenase 2 inhibitor use in patients admitted to a large teaching hospital. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12755551&form=6&db=m The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12755582&form=6&db=m Summaries for patients. The cost-effectiveness of cyclooxygenase-2 inhibitors for treating chronic arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12772009&form=6&db=m Motion--Cyclo-oxygenase-2 selective nonsteroidal anti-inflammatory drugs are as safe as placebo for the stomach: arguments against the motion. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12854282&form=6&db=m [COX-2 inhibitors: a new treatment in rheumatic diseases] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12911235&form=6&db=m Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12914871&form=6&db=m Cardiovascular thrombotic events in arthritis trials of the cyclooxygenase-2 inhibitor celecoxib. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14506909&form=6&db=m Inhibition of PGE2 production by nimesulide compared with diclofenac in the acutely inflamed joint of patients with arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14558211&form=6&db=m [New studies of COX-inhibitors, yet issues remain] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14606981&form=6&db=m A cross-sectional retrospective assessment of anti-arthritic drugs in patients with arthritis in Korea. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14613417&form=6&db=m Relationship of clinical factors to the use of Cox-2 selective NSAIDs within an arthritis population in a large HMO. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623549&form=6&db=m Cyclooxygenase-2 and chemoprevention of breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14761182&form=6&db=m In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14769925&form=6&db=m Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis. causal interaction,unassigned 2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14967078&form=6&db=m Cyclooxygenase-2 inhibitors in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14994409&form=6&db=m Are preferences for cyclooxygenase-2 inhibitors influenced by the certainty effect? therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15123037&form=6&db=m The usefulness and the limitations of animal models in identifying targets for therapy in arthritis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15126263&form=6&db=m Cost-effectiveness of cyclooxygenase-2 inhibitors in chronic arthritis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151474&form=6&db=m Cardiovascular effects of selective cyclooxygenase-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15225171&form=6&db=m Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and patient demographics. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240720&form=6&db=m Inhibition of farnesyltransferase prevents collagen-induced arthritis by down-regulation of inflammatory gene expression through suppression of p21(ras)-dependent NF-kappaB activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15266215&form=6&db=m Effects of the cyclooxygenase-2 specific inhibitor valdecoxib versus nonsteroidal antiinflammatory agents and placebo on cardiovascular thrombotic events in patients with arthritis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15277581&form=6&db=m ABT-963 [2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], a highly potent and selective disubstituted pyridazinone cyclooxgenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15297470&form=6&db=m Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15311968&form=6&db=m An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures. unassigned -
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15326524&form=6&db=m 2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation. ongoing research,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15341245&form=6&db=m Utilization patterns of cyclooxygenase-2 inhibitors among patients with arthritis in a managed care setting. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385947&form=6&db=m Cardiovascular risk and COX-2 inhibition in rheumatological practice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15454838&form=6&db=m Pharmacokinetics of rofecoxib in children with sickle cell hemoglobinopathy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456329&form=6&db=m Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis. therapeutic application,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15509468&form=6&db=m The management of pain in arthritis and the use of cyclooxygenase-2 inhibitors: new paradigms and insights. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15573802&form=6&db=m Formulary decision-making considerations: COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15579005&form=6&db=m Novel insights and therapeutical applications in the field of inhibitors of COX-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15641079&form=6&db=m Inhibition of interleukin-1beta-induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Delta12,14-prostaglandin J2 through a histone deacetylase-independent mechanism. causal interaction,unassigned 2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15731291&form=6&db=m Efficacy of cyclo-oxygenase-2 inhibition by etoricoxib and naproxen on the axial manifestations of ankylosing spondylitis in the presence of peripheral arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15789889&form=6&db=m The effects of Celecoxib on inflammation and synovial microcirculation in murine antigen-induced arthritis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15818647&form=6&db=m Minimizing complications from nonsteroidal antiinflammatory drugs: cost-effectiveness of competing strategies in varying risk groups. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15862805&form=6&db=m Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15881475&form=6&db=m Assessing the cost-effectiveness of COX-2 specific inhibitors for arthritis in the Veterans Health Administration. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15921858&form=6&db=m Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974939&form=6&db=m COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16013657&form=6&db=m Managing arthritis pain amid evolving science on pain relievers. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051509&form=6&db=m Reliability and validity of a modified Brief Pain Inventory short form in patients with osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16101563&form=6&db=m Monocyte cyclooxygenase-2 activity: a new therapeutic target for atherosclerosis? ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16168076&form=6&db=m Current state of therapy for pain and inflammation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16224510&form=6&db=m Going against the flow: the impact of PHARMAC not funding COX-2 inhibitors for chronic arthritis. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16259716&form=6&db=m Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats. therapeutic application,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16331802&form=6&db=m An evidence-based approach to prescribing nonsteroidal antiinflammatory drugs. Third Canadian Consensus Conference. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16465610&form=6&db=m The role of macrophage migration inhibitory factor in the inflammatory immune response and rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16477171&form=6&db=m Cyclooxygenase-2 inhibitors: what went wrong? ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16534727&form=6&db=m Selective Inhibition of COX-2 by a Standardized CO2 Extract of Humulus lupulus in vitro and its Activity in a Mouse Model of Zymosan-Induced Arthritis. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16556900&form=6&db=m Sex differences in inflammation and inflammatory pain in cyclooxygenase-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16651060&form=6&db=m Comparing rates of dyspepsia with Coxibs vs NSAID+PPI: a meta-analysis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16737538&form=6&db=m Accounting for the increase in NSAID expenditure: substitution or leakage? therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778222&form=6&db=m Changes in antitumor response in C57BL/6J-Min/+ mice during long-term administration of a selective cyclooxygenase-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892400&form=6&db=m Detection of Overexpressed COX-2 in Precancerous Lesions of Hamster Pancreas and Lungs by Molecular Imaging: Implications for Early Diagnosis and Prevention. causal interaction,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16913025&form=6&db=m The COX-2 controversy continues ...but NSAIDs are still in the lead. New studies shed light on risks associated with popular arthritis painkillers. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16973887&form=6&db=m Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17017983&form=6&db=m Interactions between oxicams and membrane bilayers: an explanation for their different COX selectivity. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17150210&form=6&db=m Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244362&form=6&db=m Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17284570&form=6&db=m Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17303969&form=6&db=m Thromboembolic cardiovascular risk among arthritis patients using cyclooxygenase-2-selective inhibitor or nonselective cyclooxygenase inhibitor nonsteroidal anti-inflammatory drugs. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17316604&form=6&db=m Pharmacological characterization of a selective COX-2 inhibitor MF-tricyclic, [3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone], in multiple preclinical species. therapeutic application,unassigned 2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17408711&form=6&db=m Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437665&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475558&form=6&db=m Natural products as a gold mine for arthritis treatment. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17592506&form=6&db=m The snake venom metalloproteinase BaP1 induces joint hypernociception through TNF-alpha and PGE2-dependent mechanisms. causal interaction,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612045&form=6&db=m Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair. therapeutic application,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612049&form=6&db=m Cardiovascular effects of the selective cyclooxygenase-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612052&form=6&db=m Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17631131&form=6&db=m Effect of risk factors on complicated and uncomplicated ulcers in the TARGET lumiracoxib outcomes study. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17979648&form=6&db=m Niosomal gel for site-specific sustained delivery of anti-arthritic drug: in vitro-in vivo evaluation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17984087&form=6&db=m Inhibition of delayed rectifier potassium channels and induction of arrhythmia: a novel effect of celecoxib and the mechanism underlying it. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173977&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220787&form=6&db=m Computer aided drug design approaches to develop cyclooxygenase based novel anti-inflammatory and anti-cancer drugs. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230053&form=6&db=m Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18289124&form=6&db=m Compositions for treatment of cancer and inflammation. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18297851&form=6&db=m [Side effects of COX-2 selective inhibitors. Critic related with its administration in patients with rheumatoid arthritis and osteoarthritis] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18360581&form=6&db=m Etoricoxib for arthritis and pain management. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18405470&form=6&db=m Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438856&form=6&db=m Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438879&form=6&db=m Arthritis develops but fails to resolve during inhibition of cyclooxygenase 2 in a murine model of Lyme disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18473007&form=6&db=m Selective COX-2 inhibitors, NSAIDs and cardiovascular events - is celecoxib the safest choice? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18513703&form=6&db=m CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18690976&form=6&db=m Risk-benefit perspectives in COX-2 blockade. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758904&form=6&db=m Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19135346&form=6&db=m Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19155154&form=6&db=m Determination of two COX-2 inhibitors in serum and synovial fluid of patients with inflammatory arthritis by ultra performance liquid chromatography-inductively coupled plasma mass spectroscopy and quadrupole time-of-flight mass spectrometry. unassigned -
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19184362&form=6&db=m Combination therapies that inhibit cyclooxygenase-2 and leukotriene synthesis prevent disease in murine collagen induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239908&form=6&db=m Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19570240&form=6&db=m Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-kappaB: a study on induced arthritis in rats. therapeutic application,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19784684&form=6&db=m Contrasting Effects of n-3 and n-6 Fatty Acids on Cyclooxygenase-2 in Model Systems for Arthritis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19844943&form=6&db=m NSAID switching and short-term gastrointestinal outcome rates after the withdrawal of rofecoxib. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19889287&form=6&db=m Update on the management of pain in arthritis and the use of cyclooxygenase-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20309843&form=6&db=m Bacopa monniera (L.) wettst inhibits type ii collagen-induced arthritis in rats. causal interaction,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20435922&form=6&db=m Resolution of Inflammation in Murine Autoimmune Arthritis Is Disrupted by Cyclooxygenase-2 Inhibition and Restored by Prostaglandin E2-Mediated Lipoxin A4 Production. causal interaction,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20476993&form=6&db=m COX-2 inhibition and pain management: a review summary. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20658182&form=6&db=m Possible Protective Role of Chloramphenicol in TSST-1 and Coagulase-Positive Staphylococcus aureus-Induced Septic Arthritis with Altered Levels of Inflammatory Mediators. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20698743&form=6&db=m Effect of selective COX-2 inhibitor, celecoxib on adjuvant-induced arthritis model in irradiated rats. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20948372&form=6&db=m NSAID-induced gastrointestinal and cardiovascular injury. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21266028&form=6&db=m mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21348304&form=6&db=m [Novel synthetic method and analgesic activity of tepoxalin]. therapeutic application,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21560115&form=6&db=m Genetics of arthritis severity: A genome-wide and species-wide dissection in HS mice. ongoing research,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21561397&form=6&db=m Gastrointestinal tolerability of NSAIDs in elderly patients: a pooled analysis of 21 randomized clinical trials with celecoxib and nonselective NSAIDs. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21688637&form=6&db=m [Can COX-2 selective inhibitor prevent NSAIDs-related GI toxicity?]. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21884017&form=6&db=m Blood Pressure and Cardiovascular Outcomes in Patients Taking Nonsteroidal Antiinflammatory Drugs. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21979415&form=6&db=m Serum concentrations of cyclooxygenase-2 in patients with systemic sclerosis: association with lower frequency of pulmonary fibrosis. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22084715&form=6&db=m Efficacy and Safety of COX-2 Inhibitors in the Clinical Management of Arthritis: Mini Review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22611307&form=6&db=m Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22688643&form=6&db=m Celecoxib Enhances the Anti-inflammatory Effects of Farnesylthiosalicylic Acid on T Cells Independent of Prostaglandin E(2) Production. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22833372&form=6&db=m Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain. therapeutic application,unassigned 2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22910222&form=6&db=m The use of anti-COX2 siRNA coated onto PLGA nanoparticles loading dexamethasone in the treatment of rheumatoid arthritis. ongoing research,unassigned 2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22943552&form=6&db=m A case of acute liver failure due to etodolac. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23483440&form=6&db=m Topically Applied Phospho-Sulindac Hydrogel is Efficacious and Safe in the Treatment of Experimental Arthritis in Rats. ongoing research,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24279689&form=6&db=m Prostanoid Receptor EP2 as a Therapeutic Target. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24502626&form=6&db=m Cardiovascular risks of cyclooxygenase-2 inhibitors and traditional anti-inflammatory drugs: necessary but not sufficient for clinical decision making. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24639012&form=6&db=m Anti-inflammatory Potential of Alpha-Linolenic Acid Mediated Through Selective COX Inhibition: Computational and Experimental Data. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24680620&form=6&db=m Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681547&form=6&db=m Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25225849&form=6&db=m Non-steroidal anti-inflammatory drugs for acute gout. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25362177&form=6&db=m A deficiency in the prostaglandin D2 receptor CRTH2 exacerbates adjuvant-induced joint inflammation. causal interaction,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25860026&form=6&db=m Colonic delivery of celecoxib is a potential pharmaceutical strategy for repositioning the selective COX-2 inhibitor as an anti-colitic agent. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25893742&form=6&db=m Paederia foetida Linn. inhibits adjuvant induced arthritis by suppression of PGE(2) and COX-2 expression via nuclear factor-?B. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505439&form=6&db=m Differential expression of COX-2 in osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26740668&form=6&db=m Identification and Characterization of Novel Microsomal Prostaglandin E Synthase-1 Inhibitors for Analgesia. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27066320&form=6&db=m The melanocortin receptor type 3 agonist d-Trp(8)-?MSH decreases inflammation and muscle wasting in arthritic rats. unassigned -
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27175064&form=6&db=m Comparison of benefit-risk preferences of patients and physicians regarding cyclooxygenase-2 inhibitors using discrete choice experiments. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27196460&form=6&db=m Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27245339&form=6&db=m Formoterol decreases muscle wasting as well as inflammation in the rat model of rheumatoid arthritis. diagnostic usage,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27811608&form=6&db=m Pharmacokinetics of Rofecoxib in Children With Sickle Cell Hemoglobinopathy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28298526&form=6&db=m The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages. unassigned -
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28320832&form=6&db=m G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease. therapeutic application,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28344594&form=6&db=m Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28421996&form=6&db=m Obesity does not diminish the efficacy of IL-6 signalling blockade in mice with collagen-induced arthritis. ongoing research,unassigned 2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28614768&form=6&db=m Melanocortin-4 receptor agonist (RO27-3225) ameliorates soleus but not gastrocnemius atrophy in arthritic rats. unassigned -
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29558494&form=6&db=m Ursolic acid rich Ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of COX-1, COX-2, TNF-? and IL-1: Pharmacological and docking studies. ongoing research,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29756563&form=6&db=m Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30011214&form=6&db=m Complexes of Indomethacin with 4-Carbomethoxy-pyrrolidone PAMAM Dendrimers Show Improved Anti-inflammatory Properties and Temperature-Dependent Binding and Release Profile. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30072617&form=6&db=m In Vivo Brain Imaging, Biodistribution, and Radiation Dosimetry Estimation of [11C]Celecoxib, a COX-2 PET Ligand, in Nonhuman Primates. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396759&form=6&db=m In vivo evaluation of [11C]TMI, a COX-2 selective PET tracer, in baboons. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30471320&form=6&db=m Anti-rheumatoid arthritis effects in adjuvant-induced arthritis in rats and molecular docking studies of Polygonum orientale L. extracts. therapeutic application,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30660454&form=6&db=m Scientific validation of Anti-arthritic effect of Kashayams - a polyherbal formulation in collagen induced arthritic rats. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30668316&form=6&db=m Terpenes as possible drugs for the mitigation of arthritic symptoms - A systematic review. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30715482&form=6&db=m Structural efficacy of NSAIDs, COX-2 inhibitor and glucocorticoid compared with TNF? blocker: a study in adjuvant-induced arthritis rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30881236&form=6&db=m Treatments for Inflammatory Arthritis: Potential But Unproven Role of Topical Copaiba. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666999&form=6&db=m Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31827550&form=6&db=m In Vitro Anti-Inflammatory and In Vivo Antiarthritic Activities of Aqueous and Ethanolic Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Rats. ongoing research,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894846&form=6&db=m MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32162074&form=6&db=m Polystichum braunii extracts inhibit Complete Freund's adjuvant-induced arthritis via upregulation of I-?B, IL-4, and IL-10, downregulation of COX-2, PGE2, IL-1?, IL-6, NF-?B, and TNF-?, and subsiding oxidative stress. unassigned -
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32178492&form=6&db=m An unusual case of colon perforation with multiple transmural ulcers after use of polmacoxib and everolimus in a metastatic breast cancer patient: A case report. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32569719&form=6&db=m Andrographolide attenuates complete freund's adjuvant induced arthritis via suppression of inflammatory mediators and pro-inflammatory cytokines. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32632914&form=6&db=m Radiosynthesis and evaluation of [18F]FMTP, a COX-2 PET ligand. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33064243&form=6&db=m Asphodelus tenuifolius extracts arrested inflammation and arthritis through modulation of TNF-?, NF-?B, ILs, and COX-2 activities in in vivo models. causal interaction,unassigned 1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33408499&form=6&db=m Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33442381&form=6&db=m Identification of Active Compounds From Yi Nationality Herbal Formula Wosi Influencing COX-2 and VCAM-1 Signaling. therapeutic application,unassigned 2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33447032&form=6&db=m Topical Nano-Vesicular Spanlastics of Celecoxib: Enhanced Anti-Inflammatory Effect and Down-Regulation of TNF-?, NF-?B and COX-2 in Complete Freund's Adjuvant-Induced Arthritis Model in Rats. ongoing research,unassigned 2,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33540246&form=6&db=m LncRNA H19 regulates macrophage polarization and promotes Freund's complete adjuvant-induced arthritis by upregulating KDM6A. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33739886&form=6&db=m Pinocembrin Reduces Arthritic Symptoms in Mouse Model via Targeting Sox4 Signaling Molecules. unassigned -
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33828386&form=6&db=m Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor. causal interaction,unassigned 3,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34302162&form=6&db=m Inflammation and ROS in arthritis: management by Ayurvedic medicinal plants. unassigned -
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=807954&form=6&db=m Stereoisomeric relationships among anti-inflammatory activity, inhibition of platelet aggregation, and inhibition of prostaglandin synthetase. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2128168&form=6&db=m Anti-inflammatory pharmacology and mechanism of the orally active capsaicin analogs, NE-19550 and NE-28345. diagnostic usage,unassigned 3,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2491889&form=6&db=m Antiinflammatory 2,6-di-tert-butyl-4-(2-arylethenyl)phenols. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3088612&form=6&db=m [Antiphlogistic effectiveness of combinations of inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases of the arachidonic acid cascade] ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3094043&form=6&db=m [Simultaneous and sequential inhibition of the arachidonic acid cascade by inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases in carrageenan edema and adjuvant arthritis in the rat] causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3142488&form=6&db=m Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3687578&form=6&db=m Antiinflammatory benzimidazole derivative with inhibitory effects on neutrophil function. unassigned -
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7686325&form=6&db=m The influence of anti-rheumatic drugs on hepatic mRNA levels of acute-phase proteins in rats with adjuvant arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647962&form=6&db=m Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9362323&form=6&db=m Relations between functional, inflammatory, and degenerative parameters during adjuvant arthritis in rats. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10667323&form=6&db=m Mitigation of arthritis by high-dose administration of a COX-2 inhibitor in the collagen-induced arthritis model in the mouse. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778916&form=6&db=m Effects of pentoxifylline and nabumetone on the serum levels of IL-1beta and TNFalpha in rats with adjuvant arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10958895&form=6&db=m Effects of the second-generation leukotriene B(4) receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11145026&form=6&db=m The genetic ablation of cyclooxygenase 2 prevents the development of autoimmune arthritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11519792&form=6&db=m Changes in prostaglandin E2 (PGE2) levels in paw exudate, stomach and kidney of arthritic rats: effects of flosulide. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11785783&form=6&db=m Anti-inflammatory activity of a novel selective cyclooxygenase-2 inhibitor, FR140423, on type II collagen-induced arthritis in Lewis rats. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12183639&form=6&db=m Pharmacology of celecoxib in rat brain after kainate administration. diagnostic usage,unassigned 3,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963493&form=6&db=m Role of cyclooxygenase-2, but not cyclooxygenase-1, on type II collagen-induced arthritis in DBA/1J mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15123037&form=6&db=m The usefulness and the limitations of animal models in identifying targets for therapy in arthritis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15560114&form=6&db=m Nociception and the differential expression of cyclooxygenase-1 (COX-1), the COX-1 variant retaining intron-1 (COX-1v), and COX-2 in mouse dorsal root ganglia (DRG). causal interaction,unassigned 3,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15862805&form=6&db=m Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437166&form=6&db=m Celecoxib prevents juxta-articular osteopenia and growth plate destruction adjacent to inflamed joints in rats with collagen-induced arthritis. ongoing research,unassigned 4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758904&form=6&db=m Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19686718&form=6&db=m Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression. causal interaction,unassigned 2,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20838859&form=6&db=m Lactobacillus casei reduces the Inflammatory Joint Damage Associated with Collagen-Induced Arthritis (CIA) by Reducing the Pro-Inflammatory Cytokines : Lactobacillus casei: COX-2 inhibitor. therapeutic application,unassigned 2,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21932136&form=6&db=m Anti-inflammatory effects of Clematis chinensis Osbeck extract(AR-6) may be associated with NF-?B, TNF-?, and COX-2 in collagen-induced arthritis in rat. unassigned -
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23538163&form=6&db=m Inhibitory effects of the root extract of Litsea cubeba (Lour.) Pers. on adjuvant arthritis in rats. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24932515&form=6&db=m Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27987500&form=6&db=m [Analgesic effects of ionotropic glutamate receptor antagonists MK-801 and NBQX on collagen-induced arthritis rats]. ongoing research,unassigned 3,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30831463&form=6&db=m Therapeutic effects of the total lignans from Vitex negundo seeds on collagen-induced arthritis in rats. causal interaction,unassigned 3,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894846&form=6&db=m MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32791152&form=6&db=m Polymyxin B prevents the development of adjuvant arthritis via modulation of TLR/Cox-2 signaling pathway. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Arthritis, Gouty http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16922642&form=6&db=m Clinical pharmacology of etoricoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis, Gouty http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23306170&form=6&db=m Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expression. unassigned -
1.14.99.1 Arthritis, Gouty http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30265377&form=6&db=m Frontline Science: Reprogramming COX-2, 5-LOX, and CYP4A-mediated arachidonic acid metabolism in macrophages by salidroside alleviates gouty arthritis. unassigned -
1.14.99.1 Arthritis, Infectious http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12423770&form=6&db=m Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis, Juvenile http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6772782&form=6&db=m Oligohydramnios and transient neonatal anuria: a possible association with the maternal use of prostaglandin synthetase inhibitors. causal interaction,unassigned 4,0
1.14.99.1 Arthritis, Juvenile http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12508788&form=6&db=m A selective COX-2 inhibitor, meloxicam, as a treatment option in patients with juvenile idiopathic arthritis and gastrointestinal side effects from naproxen. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Psoriatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9433877&form=6&db=m Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Arthritis, Psoriatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11550988&form=6&db=m Nephrotoxicity of selective COX-2 inhibitors. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Arthritis, Psoriatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16266429&form=6&db=m Single subject pharmacological-MRI (phMRI) study: modulation of brain activity of psoriatic arthritis pain by cyclooxygenase-2 inhibitor. unassigned -
1.14.99.1 Arthritis, Psoriatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17570469&form=6&db=m A comparison of the efficacy and safety of celecoxib 200 mg and celecoxib 400 mg once daily in treating the signs and symptoms of psoriatic arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis, Reactive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7692858&form=6&db=m Association between reactive arthritis and antecedent infection with Shigella flexneri carrying a 2-Md plasmid and encoding an HLA-B27 mimetic epitope. unassigned -
1.14.99.1 Arthritis, Reactive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9007013&form=6&db=m Characterization of the stable maintenance of the Shigella flexneri plasmid pHS-2. unassigned -
1.14.99.1 Arthritis, Reactive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109739&form=6&db=m Antiinflammatory effects of etoricoxib alone and combined with NSAIDs in LPS-induced reactive arthritis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=823876&form=6&db=m Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1673814&form=6&db=m [Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue] therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1729286&form=6&db=m In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6120390&form=6&db=m Non-steroidal anti-inflammatory agent inhibit the synthesis of IgM rheumatoid factor in vitro. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6312608&form=6&db=m The neutrophil in rheumatoid arthritis: its role and the inhibition of its activation by nonsteroidal antiinflammatory drugs. causal interaction,unassigned 2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6429243&form=6&db=m Regulation of natural killer cell activity by macrophages in the rheumatoid joint and peripheral blood. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945411&form=6&db=m Effects of tenidap on Ca(2+)- and protein kinase C-mediated protein phosphorylation, activation of the arachidonate-mobilizing phospholipase A2 and subsequent eicosanoid formation in macrophages. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8132748&form=6&db=m Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630630&form=6&db=m A review of the clinical pharmacokinetics of meloxicam. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630631&form=6&db=m A double-blind, three-week study to compare the efficacy and safety of meloxicam 7.5 mg and meloxicam 15 mg in patients with rheumatoid arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8761181&form=6&db=m Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9219313&form=6&db=m Mechanism of action of aspirin-like drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249645&form=6&db=m Outcome of specific COX-2 inhibition in rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249646&form=6&db=m COX-1 and COX-2 tissue expression: implications and predictions. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249647&form=6&db=m Pain management in osteoarthritis: the role of COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9297577&form=6&db=m Cyclooxygenase inhibitors enhance the production of tissue inhibitor-1 of metalloproteinases (TIMP-1) and pro-matrix metalloproteinase 1 (proMMP-1) in human rheumatoid synovial fibroblasts. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9422509&form=6&db=m PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9433877&form=6&db=m Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589803&form=6&db=m Development of an HPLC assay to study the effect of endogenous and exogenous substances on heat-induced aggregation of human serum albumin. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9751091&form=6&db=m Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831332&form=6&db=m Possible background mechanisms of the effectiveness of cyclooxygenase-2 inhibitors in the treatment of rheumatoid arthritis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10093892&form=6&db=m [Specific COX-2 inhibitors: prospects of therapy with new analgesic and anti-inflammatory substances] diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10193997&form=6&db=m Role of cyclooxygenase-1 and -2 in health and disease. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390126&form=6&db=m Role and regulation of cyclooxygenase-2 during inflammation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10399316&form=6&db=m Cyclooxygenase-1 and -2 isoenzymes. causal interaction,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411562&form=6&db=m Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10418338&form=6&db=m (-)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10463513&form=6&db=m Selective cyclooxygenase-2 inhibitors for the treatment of arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10509845&form=6&db=m Celecoxib, a selective cyclooxygenase-2 inhibitor for the treatment of rheumatoid arthritis and osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567385&form=6&db=m Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism. causal interaction,unassigned 2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10580457&form=6&db=m Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. therapeutic application,unassigned 2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10606360&form=6&db=m Celecoxib, a specific COX-2 inhibitor, has no significant effect on methotrexate pharmacokinetics in patients with rheumatoid arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617996&form=6&db=m Evening primrose oil and borage oil in rheumatologic conditions. therapeutic application,unassigned 3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10643176&form=6&db=m Celecoxib for the treatment of pain and inflammation: the preclinical and clinical results. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10701683&form=6&db=m FK506 augments glucocorticoid-mediated cyclooxygenase-2 down-regulation in human rheumatoid synovial fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10708568&form=6&db=m Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710483&form=6&db=m COX-2 and colon cancer: Potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10719816&form=6&db=m Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762021&form=6&db=m COX-2 and colon cancer: potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10804043&form=6&db=m Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10812057&form=6&db=m Preferential inhibition of cyclooxygenase-2 by meloxicam in human rheumatoid synoviocytes. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10852985&form=6&db=m Methotrexate as a preferential cyclooxygenase 2 inhibitor in whole blood of patients with rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,4
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10900877&form=6&db=m [New treatment of pain and fever in rheumatoid arthritis and arthrosis. The first cyclooxygenase-2 inhibitors show promising results] therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10943882&form=6&db=m Thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors. A report of four cases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005360&form=6&db=m Cyclooxygenase-2 inhibitor celecoxib: a possible cause of gastropathy and hypoprothrombinemia. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11028754&form=6&db=m Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032097&form=6&db=m Defining COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032965&form=6&db=m Role of cyclooxygenases in angiogenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11087881&form=6&db=m Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090038&form=6&db=m COX-2 inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11109595&form=6&db=m [Non-steroidal anti-inflammatory agents with selective inhibitory activity on cyclooxygenase-2. Interest and future prospects] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121721&form=6&db=m Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11177775&form=6&db=m COX-2 inhibitors in rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235048&form=6&db=m Successful use of cyclooxygenase-2 inhibitor in a patient with aspirin-induced asthma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238591&form=6&db=m Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. causal interaction,unassigned 3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311743&form=6&db=m Cyclooxygenase inhibitors--current status and future prospects. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11317164&form=6&db=m The hepatic safety and tolerability of the novel cyclooxygenase-2 inhibitor celecoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11418684&form=6&db=m Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11522796&form=6&db=m The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695246&form=6&db=m What have we learned from the large outcomes trials of COX-2 selective inhibitors? The rheumatologist's perspective. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11718158&form=6&db=m Celecoxib in osteoarthritis and rheumatoid arthritis: new preparation. As disappointing as rofecoxib. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11719735&form=6&db=m The human pharmacology of monocyte cyclooxygenase 2 inhibition by cortisol and synthetic glucocorticoids. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819916&form=6&db=m [Pharmacology of non-steroidal anti-inflammatory drugs and ENT pathology] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11852819&form=6&db=m [The role of cyclooxygenase and prostaglandins in the pathogenesis of rheumatoid arthritis] causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11860351&form=6&db=m Non steroidal anti-inflammatory and anti-allergy agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11892706&form=6&db=m Upper gastrointestinal tolerability of celecoxib compared with diclofenac in the treatment of osteoarthritis and rheumatoid arthritis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11906292&form=6&db=m 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1). therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961974&form=6&db=m [A critical evaluation of side effect data on COX-2 inhibitors] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11978928&form=6&db=m Migratory pulmonary infiltrates in a patient with rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994687&form=6&db=m [New nonsteroidal antiinflammatory drugs in rheumatoid arthritis] therapeutic application,unassigned 1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12022317&form=6&db=m Increase in lifetime adverse drug reactions, service utilization, and disease severity among patients who will start COX-2 specific inhibitors: quantitative assessment of channeling bias and confounding by indication in 6689 patients with rheumatoid arthritis and osteoarthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12033987&form=6&db=m A multinational randomized, controlled, clinical trial of etoricoxib in the treatment of rheumatoid arthritis [ISRCTN25142273]. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12167567&form=6&db=m Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12180720&form=6&db=m A randomized, controlled, clinical trial of etoricoxib in the treatment of rheumatoid arthritis. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204485&form=6&db=m Pharmacoeconomics of coxib therapy. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209034&form=6&db=m Efficacy and safety of valdecoxib in treating the signs and symptoms of rheumatoid arthritis: a randomized, controlled comparison with placebo and naproxen. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12233875&form=6&db=m Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12423770&form=6&db=m Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12483719&form=6&db=m Induction of apoptosis in rheumatoid synovial fibroblasts by celecoxib, but not by other selective cyclooxygenase 2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12509612&form=6&db=m Cost-effectiveness of low dose corticosteroids versus non-steroidal anti-inflammatory drugs and COX-2 specific inhibitors in the long-term treatment of rheumatoid arthritis. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12621554&form=6&db=m [Enhancement by FK506 of triptolide-induced inhibition of expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts] ongoing research,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637116&form=6&db=m The prevalence of cardiorenal risk factors in patients prescribed nonsteroidal anti-inflammatory drugs: data from managed care. diagnostic usage,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12688204&form=6&db=m [Selective Cox-2 inhibitor in osteoarthritis and rheumatoid arthritis. No increased risk for the heart] causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12703120&form=6&db=m [Selective cyclooxygenase-2 inhibitors and the digestive tract] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12716445&form=6&db=m COX-2: Where are we in 2003? - Be strong and resolute: continue to use COX-2 selective inhibitors at recommended dosages in appropriate patients. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730088&form=6&db=m Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy men. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782016&form=6&db=m The role of COX-2 in angiogenesis and rheumatoid arthritis. causal interaction,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794822&form=6&db=m Selective inhibition of cyclooxygenase 2-generated prostaglandin E2 synthesis in rheumatoid arthritis synoviocytes by taurine chloramine. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12797547&form=6&db=m The cox-2-specific inhibitor celecoxib inhibits adenylyl cyclase. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12800058&form=6&db=m Lumiracoxib (Novartis). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12804506&form=6&db=m Single dose oral celecoxib for postoperative pain. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12868200&form=6&db=m [Coxibs: highly selective cyclooxygenase-2 inhibitors. Part I. Clinical efficacy] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12904159&form=6&db=m Cardiovascular hazard of selective COX-2 inhibitors: myth or reality? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907325&form=6&db=m The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13680139&form=6&db=m Cost-effectiveness analysis of NSAIDs, NSAIDs with concomitant therapy to prevent gastrointestinal toxicity, and COX-2 specific inhibitors in the treatment of rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14531955&form=6&db=m Atherosclerotic cardiovascular disease in rheumatoid arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552698&form=6&db=m The prospective use of COX-2 inhibitors for the treatment of temporomandibular joint inflammatory disorders. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552704&form=6&db=m Clinical pharmacology of selective COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14585912&form=6&db=m Channelling of patients taking NSAIDs or cyclooxygenase-2-specific inhibitors and its effect on interpretation of outcomes. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14613417&form=6&db=m Relationship of clinical factors to the use of Cox-2 selective NSAIDs within an arthritis population in a large HMO. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14687407&form=6&db=m Osteoarthritis and rheumatoid arthritis: will new data clarify the risk:benefit ratio of cyclooxygenase-2 inhibitors? unassigned -
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14712755&form=6&db=m Verification of a decision analytic model assumption using real-world practice data: implications for the cost effectiveness of cyclo-oxygenase 2 inhibitors (COX-2s). diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729583&form=6&db=m Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15035793&form=6&db=m Mechanisms of action of paracetamol and related analgesics. therapeutic application,unassigned 3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067740&form=6&db=m [Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts] diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15068837&form=6&db=m Celecoxib: a potent cyclooxygenase-2 inhibitor in cancer prevention. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15077295&form=6&db=m Cyclooxygenase 2-derived prostaglandin E2 production by corticotropin-releasing hormone contributes to the activated cAMP response element binding protein content in rheumatoid arthritis synovial tissue. therapeutic application,unassigned 1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15100180&form=6&db=m Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15100590&form=6&db=m A randomized, double-blind, parallel-group study comparing the analgesic effect of etoricoxib to placebo, naproxen sodium, and acetaminophen with codeine using the dental impaction pain model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15121040&form=6&db=m An economic approach to health care. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15130753&form=6&db=m Selective COX-2 inhibitor, NS-398, inhibits the replicative senescence of cultured dermal fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15133778&form=6&db=m Drug switching patterns among patients with rheumatoid arthritis and osteoarthritis using COX-2 specific inhibitors and non-specific NSAIDs. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15167967&form=6&db=m Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15225373&form=6&db=m Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256475&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265936&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15297470&form=6&db=m Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313405&form=6&db=m Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355747&form=6&db=m Aspirin, NSAIDs, and COX-2 inhibitors in cardiovascular disease: possible interactions and implications for treatment of rheumatoid arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476906&form=6&db=m Effects of valdecoxib in the treatment of chronic low back pain: results of a randomized, placebo-controlled trial. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15485309&form=6&db=m Celecoxib: a novel treatment for lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15487881&form=6&db=m Risk assessment of NSAID-induced gastrointestinal toxicity in ambulatory care patients. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15638077&form=6&db=m Isolation and structural characterization of the photolysis products of etoricoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15651713&form=6&db=m Efficacy of lumiracoxib in osteoarthritis: a review of nine studies. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15662292&form=6&db=m Mechanism of action of paracetamol. unassigned -
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15669946&form=6&db=m Prescriptions for cyclooxygenase-2 inhibitors and other nonsteroidal anti-inflammatory agents in a medicaid managed care population: African Americans versus Caucasians. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719708&form=6&db=m Rationale for testing the cardiovascular risk for patients with COX-2 inhibitors on the basis of biomarker NT-proBNP. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15732722&form=6&db=m [Use of meloxicam (movalis) in patients with rheumatic diseases with concomitant coronary heart disease] diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15775145&form=6&db=m [Preventing effects of COX-2 inhibitors on rheumatoid joint destruction] causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15799403&form=6&db=m [Selective COX-2 inhibitors for therapy of rheumatoid arthritis] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15827035&form=6&db=m A regional audit of the use of COX-2 selective non-steroidal anti-inflammatory drugs (NSAIDs) in rheumatology clinics in the West Midlands, in relation to NICE guidelines. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15851377&form=6&db=m FK506 enhances triptolide-induced down-regulation of cyclooxygenase-2, inducible nitric oxide synthase as well as their products PGE2 and NO in TNF-alpha-stimulated synovial fibroblasts from rheumatoid arthritic patients. ongoing research,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15853470&form=6&db=m Valdecoxib for the management of chronic and acute pain. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870389&form=6&db=m A novel celecoxib derivative potently induces apoptosis of human synovial fibroblasts. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15881487&form=6&db=m Lumiracoxib in the treatment of osteoarthritis, rheumatoid arthritis and acute postoperative dental pain: results of three dose-response studies. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974939&form=6&db=m COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974941&form=6&db=m Global safety of coxibs and NSAIDs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15999628&form=6&db=m [The medical reason for the prescription of COX-2 selective cyclo oxygenase inhibitor rofecoxib for the treatment of rheumatoid arthritis. A post-marketing surveillance study from Austria] therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16121292&form=6&db=m Novel therapeutic strategies. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16178945&form=6&db=m Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16259055&form=6&db=m Molecular targets of dietary polyphenols with anti-inflammatory properties. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16372823&form=6&db=m Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16418805&form=6&db=m COX-2 Inhibitors Modulate IL-12 Signaling Through JAK-STAT Pathway Leading to Th1 Response in Experimental Allergic Encephalomyelitis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16529763&form=6&db=m Improved solubilization of Celecoxib in U-type nonionic microemulsions and their structural transitions with progressive aqueous dilution. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16597712&form=6&db=m A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785830&form=6&db=m Expectations from patients with rheumatoid arthritis regarding COX-2s: cutting to the heart of the matter. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16821264&form=6&db=m Cyclooxygenase-2 genotype and rheumatoid arthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16875903&form=6&db=m Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis. unassigned -
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16922642&form=6&db=m Clinical pharmacology of etoricoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17067557&form=6&db=m Melittin inhibits inflammatory target gene expression and mediator generation via interaction with IkappaB kinase. diagnostic usage,unassigned 2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17143555&form=6&db=m MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production. ongoing research,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17359944&form=6&db=m Celecoxib inhibits Na+ currents in rat dorsal root ganglion neurons. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17459794&form=6&db=m COXIBs and non-selective NSAIDs in the gastroenterological setting: what should patients and physicians do? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17553852&form=6&db=m A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis. causal interaction,unassigned 2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17596188&form=6&db=m Flurbiprofen in the symptomatic management of rheumatoid arthritis: a valuable alternative. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17603251&form=6&db=m Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17611980&form=6&db=m The effect of low-dose aspirin on the decreased risk of development of dyspepsia and gastrointestinal ulcers associated to cyclooxygenase-2 selective inhibitors. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638098&form=6&db=m Etodolac: An overview of a selective COX-2 inhibitor. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17666446&form=6&db=m The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17697449&form=6&db=m Etoricoxib versus naproxen in patients with rheumatoid arthritis: a prospective, randomized, comparator-controlled 121-week trial. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17763056&form=6&db=m Influence of polymers on the bioavailability of microencapsulated celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786275&form=6&db=m Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17848581&form=6&db=m Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. therapeutic application,unassigned 2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17910039&form=6&db=m Glucocorticoid-induced leucine zipper (GILZ) mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17999057&form=6&db=m Clinical use and pharmacological properties of selective COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18261308&form=6&db=m [Effects of RNAi on cyclooxygenase-2 expression and biologic activity of human rheumatoid arthritis synovial fibroblasts] diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18297851&form=6&db=m [Side effects of COX-2 selective inhibitors. Critic related with its administration in patients with rheumatoid arthritis and osteoarthritis] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381795&form=6&db=m Cyclooxygenase-2 polymorphisms and risk of rheumatoid arthritis in Koreans. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18405470&form=6&db=m Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18465536&form=6&db=m NCX-4016 (NicOx SA). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758904&form=6&db=m Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18802115&form=6&db=m Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017993&form=6&db=m Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203472&form=6&db=m Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19327236&form=6&db=m Effects of celecoxib on the expression of osteoprotegerin, energy metabolism and cell viability in cultured human osteoblastic cells. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19405952&form=6&db=m Apigenin, a nonmutagenic dietary flavonoid suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19669924&form=6&db=m Pharmacophore generation and atom-based 3D-QSAR of novel 2-(4-methylsulfonylphenyl)pyrimidines as COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20067770&form=6&db=m Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110006&form=6&db=m Changes in physicians' practice of prescribing cyclooxygenase-2 inhibitor after market withdrawal of rofecoxib: a retrospective study of physician-patient pairs in Taiwan. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20178133&form=6&db=m DMARD aurothiomalate inhibits COX-2, MMP-3 and IL-6 expression in chondrocytes by increasing MKP-1 expression and decreasing p38 phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20198312&form=6&db=m Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20224826&form=6&db=m [Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20363696&form=6&db=m Formulation and evaluation of mouth dissolving tablets of the Etoricoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20391510&form=6&db=m Low-dose aspirin in the primary prevention of rheumatoid arthritis: the Women's Health Study. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20688263&form=6&db=m Fish oil supplementation increases the cyclooxygenase inhibitory activity of paracetamol in rheumatoid arthritis patients. unassigned -
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20887233&form=6&db=m Cyclic mechanical stretch downregulates IL-1β-induced COX-2 expression and PGE2 production in rheumatoid arthritis fibroblast-like synoviocytes. unassigned -
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21031267&form=6&db=m Ethyl acetate fraction from Cudrania tricuspidata inhibits IL-1?-induced rheumatoid synovial fibroblast proliferation and MMPs, COX-2 and PGE2 production. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042022&form=6&db=m Efficacy and Safety of the Selective Cyclooxygenase-2 Inhibitor Celecoxib in the Treatment of Rheumatoid Arthritis and Osteoarthritis in Japan. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21142617&form=6&db=m Persistence with non-selective NSAIDs and celecoxib among patients with gastroesophageal reflux disease and osteoarthritis or rheumatoid arthritis. unassigned -
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285160&form=6&db=m A 24-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy of Oral SCIO-469, a p38 Mitogen-activated Protein Kinase Inhibitor, in Patients with Active Rheumatoid Arthritis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21298002&form=6&db=m Prostaglandin E2 synthesizing enzymes in rheumatoid arthritis B cells and the effects of B cell depleting therapy on enzyme expression. unassigned -
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21485709&form=6&db=m Bioequivalence study of two brands of meloxicam tablets in healthy human Pakistani male subjects. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21701768&form=6&db=m A glycoprotein from Porphyra yezoensis produces anti-inflammatory effects in liposaccharide-stimulated macrophages via the TLR4 signaling pathway. causal interaction,unassigned 1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21794625&form=6&db=m Pattern of use and safety of non-steroidal anti-inflammatory drugs in rheumatoid arthritis patients. A prospective analysis from clinical practice. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21900785&form=6&db=m Meta-analysis: cyclooxygenase-2 inhibitors are no better than nonselective nonsteroidal anti-inflammatory drugs with proton pump inhibitors in regard to gastrointestinal adverse events in osteoarthritis and rheumatoid arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21904784&form=6&db=m Celecoxib, a cyclooxygenase-2 inhibitor, improved upper gastrointestinal lesions in rheumatoid arthritis patients as assessed by endoscopic evaluation. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21905970&form=6&db=m Further assessment of the clinically effective dose range of etoricoxib: a randomized, double-blinded, placebo-controlled trial in rheumatoid arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22114888&form=6&db=m Managing the adverse effects of nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22149896&form=6&db=m Comparative Study of Normal and Rheumatoid Arthritis Fibroblast-Like Synoviocytes Proliferation under Cyclic Mechanical Stretch: Role of Prostaglandin E(2). causal interaction,unassigned 3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160883&form=6&db=m In vitro characterization of chitosan gels for buccal delivery of celecoxib: influence of a penetration enhancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340319&form=6&db=m Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22373734&form=6&db=m Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22592909&form=6&db=m Quercetin inhibits IL-1?-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22898213&form=6&db=m Current considerations for the management of musculoskeletal pain in Asian countries: a special focus on cyclooxygenase-2 inhibitors and non-steroid anti-inflammation drugs. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357220&form=6&db=m Cox-2 gene variants in migraine. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23532053&form=6&db=m Matching by Propensity Score in Cohort Studies with Three Treatment Groups. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23789712&form=6&db=m Murine mPGES-1 3D structure elucidation and inhibitors binding mode predictions by homology modeling and site-directed mutagenesis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23872401&form=6&db=m Enhancement of PLGF production by 15-(S)-HETE via PI3K-Akt, NF-?B and COX-2 pathways in rheumatoid arthritis synovial fibroblast. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23899748&form=6&db=m Aldosterone glucuronidation inhibition as a potential mechanism for arterial dysfunction associated with chronic celecoxib and diclofenac use in patients with rheumatoid arthritis. ongoing research,unassigned 3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23934131&form=6&db=m Kaempferol inhibits IL?1??induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX?2, PGE2 and MMPs. causal interaction,unassigned 3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24082899&form=6&db=m In vitro cytotoxic evaluation of some synthesized COX-2 inhibitor derivatives against a panel of human cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24472266&form=6&db=m Celecoxib, a selective cyclooxygenase-2 inhibitor, reduces level of a bone resorption marker in postmenopausal women with rheumatoid arthritis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24514915&form=6&db=m Persisting eicosanoid pathways in rheumatic diseases. causal interaction,unassigned 1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24671668&form=6&db=m Sulforaphane Inhibits IL-1?-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts and the Production of MMPs, COX-2, and PGE2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24680620&form=6&db=m Therapeutic effects of standardized Vitex negundo seeds extract on complete Freund's adjuvant induced arthritis in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25299270&form=6&db=m Ethyl acetate fraction from Angelica sinensis inhibits IL-1?-induced rheumatoid synovial fibroblast proliferation and COX-2, PGE2, and MMPs production. ongoing research,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25375820&form=6&db=m Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433956&form=6&db=m How to mechanistically explain the CONDOR study data. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25879879&form=6&db=m Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25886874&form=6&db=m Do COX-2 inhibitors provide additional pain relief and anti-inflammatory effects in patients with rheumatoid arthritis who are on biological disease-modifying anti-rheumatic drugs and/or corticosteroids? Post-hoc analyses from a randomized clinical trial with etoricoxib. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26130073&form=6&db=m Targeted knockout of TNF-? by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats. causal interaction,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26182160&form=6&db=m Effect of the misoprostol-rebamipide combination on iron deficiency anemia in patients under long-term cyclooxygenase-2 selective inhibitor treatment for small bowel ulcers. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498361&form=6&db=m Can active components of licorice, glycyrrhizin and glycyrrhetinic acid, lick rheumatoid arthritis? therapeutic application,unassigned 1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505439&form=6&db=m Differential expression of COX-2 in osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26567045&form=6&db=m Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner. ongoing research,unassigned 1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26799426&form=6&db=m Anti-arthritogenic effect of Saponin-1 by alteration of Th1/Th2 cytokine paradigm in arthritic mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893662&form=6&db=m Paeoniflorin ameliorates rheumatoid arthritis in rat models through oxidative stress, inflammation and cyclooxygenase 2. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26981698&form=6&db=m Celecoxib for the treatment of pain and inflammation: the preclinical and clinical results. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27180880&form=6&db=m Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27313839&form=6&db=m Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27502582&form=6&db=m Evaluation of two doses of etoricoxib, a COX-2 selective non-steroidal anti-inflammatory drug (NSAID), in the treatment of Rheumatoid Arthritis in a double-blind, randomized controlled trial. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27769393&form=6&db=m Simultaneous profiling of eicosanoid metabolome in plasma by UPLC-MS/MS method: Application to identify potential makers for rheumatoid arthritis. diagnostic usage,unassigned 3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27790020&form=6&db=m Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27864660&form=6&db=m Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metabolite. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28050748&form=6&db=m Development of Diagnostic Techniques for Early Rheumatoid Arthritis Using Positron Emission Tomography with [(11)C]PK11195 and [(11)C]Ketoprofen Tracers. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28075587&form=6&db=m Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28101182&form=6&db=m Protective effect of taraxasterol against rheumatoid arthritis by the modulation of inflammatory responses in mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28288820&form=6&db=m Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-?B in human rheumatoid arthritis synovial fibroblasts. ongoing research,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28532672&form=6&db=m Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1? signaling in rheumatoid arthritis synovial fibroblasts. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28818745&form=6&db=m A systematic review on the role of eicosanoid pathways in rheumatoid arthritis. therapeutic application,unassigned 3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29425654&form=6&db=m Anti-inflammatory and anti-arthritic effects of the ethanolic extract of Aralia continentalis Kitag. in IL-1?-stimulated human fibroblast-like synoviocytes and rodent models of polyarthritis and nociception. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30143947&form=6&db=m Preclinical Explorative Assessment of Celecoxib-Based Biocompatible Lipidic Nanocarriers for the Management of CFA-Induced Rheumatoid Arthritis in Wistar Rats. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186500&form=6&db=m Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase-2 and inflammatory factors. unassigned -
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30314410&form=6&db=m Effects of human cyclooxygenase-2 gene silencing on synovial cells of rheumatoid arthritis mediated by lentivirus. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30347274&form=6&db=m Preparation, characterization, and evaluation of celecoxib eutectic mixtures with adipic acid/saccharin for improvement of wettability and dissolution rate. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30718447&form=6&db=m Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30774225&form=6&db=m Meloxicam in the management of post-operative pain: Narrative review. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31003542&form=6&db=m Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31276975&form=6&db=m Mechanism of action of celastrol against rheumatoid arthritis: A network pharmacology analysis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31309487&form=6&db=m Cysteinyl leukotriene receptor antagonism: a promising pharmacological strategy for lowering the severity of arthritis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31564512&form=6&db=m Effects of Celecoxib on the QTc Interval: A Thorough QT/QTc Study. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31593087&form=6&db=m Combination of COX-2 inhibitor and metformin attenuates rate of admission in patients with rheumatoid arthritis and diabetes in Taiwan. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666999&form=6&db=m Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894846&form=6&db=m MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32261712&form=6&db=m Folic acid-conjugated glucose and dextran coated iron oxide nanoparticles as MRI contrast agents for diagnosis and treatment response of rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32359360&form=6&db=m PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32411586&form=6&db=m Activation of inflammation and resolution pathways of lipid mediators in synovial fluid from patients with severe rheumatoid arthritis compared with severe osteoarthritis. causal interaction,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32589073&form=6&db=m Comparison of the efficacy and safety of CELBESTA® versus CELEBREX® in patients with rheumatoid arthritis: a 6-week, multicenter, double-blind, double-dummy, active-controlled, randomized, parallel-group, non-inferiority phase 4 clinical trial. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32741960&form=6&db=m Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-?B) Pathway Downregulation. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742333&form=6&db=m Serum COX-2 and FOXO3a in patients with rheumatoid arthritis and correlation with disease activity. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32749470&form=6&db=m Retraction: MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2. unassigned -
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117381&form=6&db=m Non-Transcriptional and Translational Function of Canonical NF-?B Signaling in Activating ERK1/2 in IL-1?-Induced COX-2 Expression in Synovial Fibroblasts. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33438260&form=6&db=m Exogenous ATP modulates PGE2 release in macrophages through sustained phosphorylation of CDK9 and p38 MAPK. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485983&form=6&db=m A hybrid platform featuring nanomagnetic ligand fishing for discovering COX-2 selective inhibitors from aerial part of Saussurea laniceps Hand.-Mazz. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34304363&form=6&db=m Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism. therapeutic application,unassigned 4,0
1.14.99.1 Arthritis, Rheumatoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34539799&form=6&db=m Traditional Chinese Medicine Aconiti Radix Cocta Improves Rheumatoid Arthritis via Suppressing COX-1 and COX-2. therapeutic application,unassigned 1,0
1.14.99.1 Arthus Reaction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539337&form=6&db=m Release of eicosanoids in rat peritoneal cavity during the Arthus reaction. Effect of the PAF-antagonist BN-52021 and indomethacin. causal interaction,unassigned 3,0
1.14.99.1 Arthus Reaction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2825482&form=6&db=m Leukotriene B4 production and pharmacologic regulation of reverse passive Arthus pleurisy: importance of antigen dose. unassigned -
1.14.99.1 Arthus Reaction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3156814&form=6&db=m Ex vivo effects of nonsteroidal antiinflammatory drugs on arachidonic acid metabolism in neutrophils from a reverse passive Arthus reaction. ongoing research,unassigned 1,0
1.14.99.1 Arthus Reaction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6452106&form=6&db=m Inhibition of thrombocytopenic episodes caused by the Arthus reaction, the sub-lethal Forssman reaction and ADP. therapeutic application,unassigned 1,0
1.14.99.1 Arthus Reaction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10708727&form=6&db=m Anti-inflammatory action of a novel peptide, SEK-1005, isolated from a Streptomyces. therapeutic application,unassigned 2,0
1.14.99.1 Asbestosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823297&form=6&db=m Expression of cyclooxygenase-2 in human lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Asbestosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050069&form=6&db=m COX-2 is widely expressed in metaplastic epithelium in pulmonary fibrous disorders. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Ascorbic Acid Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6417673&form=6&db=m Effects of ascorbic acid deficiency on the in vitro biosynthesis of cyclooxygenase metabolites in guinea pig lungs. ongoing research,unassigned 4,0
1.14.99.1 Aspergillosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32102903&form=6&db=m 12/15-Lipoxygenase Deficiency Impairs Neutrophil Granulopoiesis and Lung Proinflammatory Responses to Aspergillus fumigatus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Asthenozoospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24981555&form=6&db=m Interleukin-1?, cyclooxygenase-2, and hypoxia-inducible factor-1? in asthenozoospermia. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309376&form=6&db=m Increased excretion of leukotriene E4 during aspirin-induced asthma. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1481179&form=6&db=m Inhaled frusemide and exercise induced asthma: evidence of a role for inhibitory prostanoids. therapeutic application,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1492794&form=6&db=m [A case of asthma relieved by aspirin--the first case in Japan and investigation of its mechanism] causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1541161&form=6&db=m Flurbiprofen (Ansaid) cross-sensitivity in an aspirin-sensitive asthmatic patient. causal interaction,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1970226&form=6&db=m Contribution of histamine and prostanoids to bronchoconstriction provoked by inhaled bradykinin in atopic asthma. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2115849&form=6&db=m The cyclooxygenase theory of aspirin-induced asthma. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2127257&form=6&db=m The influence of cyclooxygenase inhibition on the loss of bronchoconstrictor response to repeated bradykinin challenge in asthma. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2192187&form=6&db=m [Thromboxane A2 could be involved in bronchial hyperresponsiveness to methacholine in asthmatic subjects but not in bronchitic subjects] ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2203618&form=6&db=m Attenuating effect of a thromboxane synthetase inhibitor (OKY-046) on bronchial responsiveness to methacholine is specific to bronchial asthma. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2229840&form=6&db=m Salsalate cross-sensitivity in aspirin-sensitive patients with asthma. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496075&form=6&db=m Effect of indomethacin on allergen-induced asthmatic responses. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2676276&form=6&db=m New concepts in the pathogenesis of asthma. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2856172&form=6&db=m An abnormality of arachidonic acid metabolism is not a generalized phenomenon in patients with aspirin-induced asthma. therapeutic application,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3099317&form=6&db=m Protection by two ginkgolides, BN-52020 and BN-52021, against guinea-pig lung anaphylaxis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3110057&form=6&db=m Alteration in the levels of serum lipid peroxide, cyclooxygenase activity and free fatty acids in bronchial asthma. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3112539&form=6&db=m Aspirin sensitive asthma and arachidonic acid transformation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3140617&form=6&db=m Modulation of arachidonic acid metabolites as potential therapy of asthma. ongoing research,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3563114&form=6&db=m Leukotrienes and other eicosanoids as mediators of airway obstruction. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3693761&form=6&db=m Effects of inhibition of thromboxane A2 synthesis in aspirin-induced asthma. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3919888&form=6&db=m [Demonstration of specific platelet function anomaly in asthma induced by aspirin: diagnostic consequences] causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6179973&form=6&db=m An agent that releases basophil and mast cell histamine but blocks cyclooxygenase and lipoxygenase metabolism of arachidonic acid inhibits immunoglobulin E-mediated asthma in rhesus monkeys. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6337200&form=6&db=m Failure of children with asthma to respond to daily aspirin therapy. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6606363&form=6&db=m Antipyretic analgesics and the allergic patient. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6787776&form=6&db=m An inhibitor of the lipoxygenase and cyclooxygenase pathways of arachidonic acid, 5, 8, 11, 14-eicosatetraynoic acid, inhibits immunoglobulin E mediated antigen induced monkey asthma and skin reactions. ongoing research,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6896115&form=6&db=m Leukotrienes C and D induce aspirin-sensitive bronchoconstriction in the guinea-pig. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7002192&form=6&db=m Analgesics, allergy and asthma. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7316107&form=6&db=m Idiosyncrasy to pyrazolone drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7506149&form=6&db=m Nimesulide does not interfere with airway responsiveness in allergic asthma. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7648373&form=6&db=m Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7798537&form=6&db=m Direct evidence for a role of the mast cell in the nasal response to aspirin in aspirin-sensitive asthma. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8012649&form=6&db=m Asthma in children and ASA intolerance. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8202898&form=6&db=m Inhibition of sodium metabisulphite induced bronchoconstriction by frusemide in asthma: role of cyclooxygenase products. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8256883&form=6&db=m The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8564103&form=6&db=m 8-Epi-PGF2 alpha, a novel noncyclooxygenase-derived prostaglandin, constricts airways in vitro. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8575575&form=6&db=m Prostanoids and cough response to capsaicin in asthma and chronic bronchitis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8752493&form=6&db=m [Aspirin-induced asthma as an important type of bronchial asthma] causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8804929&form=6&db=m Changes in neurokinin A airway responsiveness with inhaled lysine-acetylsalicylate in asthma. causal interaction,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8838113&form=6&db=m [Molecular pharmacology and application to the bronchial asthma of thromboxane A2 antagonists] causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8950952&form=6&db=m [Thromboxane A2 receptor antagonist in asthma therapy] therapeutic application,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8994519&form=6&db=m Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9032211&form=6&db=m Prostaglandin H synthase 1 and 2 immunoreactivities in the bronchial mucosa of asthmatics. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9155828&form=6&db=m Inhibitory effect of indomethacin on tachyphylaxis in response to acetaldehyde-induced bronchoconstriction in patients with asthma. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9179403&form=6&db=m Effect of interleukin-1 beta, tumour necrosis factor-alpha and interferon-gamma on the induction of cyclo-oxygenase-2 in cultured human airway smooth muscle cells. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9416556&form=6&db=m Role of cyclooxygenase 1 and 2 in asthma and rhinitis. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9431818&form=6&db=m Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9487340&form=6&db=m Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma. diagnostic usage,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9514627&form=6&db=m The effects of ML 3000 on antigen-induced responses in sheep. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390414&form=6&db=m Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10400832&form=6&db=m Aspirin-induced asthma: advances in pathogenesis and management. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10454505&form=6&db=m Effects of lipid mediator antagonists on predominant mediator-controlled asthmatic reactions in passively sensitized guinea pigs. therapeutic application,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10673210&form=6&db=m Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10856147&form=6&db=m Effect of inhaled indomethacin in asthmatic patients taking high doses of inhaled corticosteroids. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10992560&form=6&db=m The importance of COX-2 inhibition for aspirin induced asthma. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235048&form=6&db=m Successful use of cyclooxygenase-2 inhibitor in a patient with aspirin-induced asthma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11251618&form=6&db=m COX-1 sparing drugs in aspirin-sensitive asthma. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11251623&form=6&db=m Safety of a specific COX-2 inhibitor in aspirin-induced asthma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11273789&form=6&db=m Effect of the cyclooxygenase-2 inhibitor celecoxib on bronchial responsiveness and cough reflex sensitivity in asthmatics. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11312402&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11739134&form=6&db=m Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11796443&form=6&db=m Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11818325&form=6&db=m Cyclooxygenase-2 expression during allergic inflammation in guinea-pig lungs. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819916&form=6&db=m [Pharmacology of non-steroidal anti-inflammatory drugs and ENT pathology] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11860351&form=6&db=m Non steroidal anti-inflammatory and anti-allergy agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11940059&form=6&db=m The role of COX-1 and COX-2 in asthma pathogenesis and its significance in the use of selective inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11941383&form=6&db=m Analgesics and asthma. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11964666&form=6&db=m Aspirin-induced rhinitis and asthma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11995251&form=6&db=m [Asthma with aspirin intolerance] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065343&form=6&db=m Safety of a cyclooxygenase-2 inhibitor in patients with aspirin-sensitive asthma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12195364&form=6&db=m Beneficial effect of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with asthma during viral infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209526&form=6&db=m The safety of celecoxib in patients with aspirin-sensitive asthma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12428645&form=6&db=m Aspirin intolerance and nasal polyposis. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12704352&form=6&db=m A controlled study of 9alpha,11beta-PGF2 (a prostaglandin D2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls after aspirin challenge. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12743549&form=6&db=m Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12743569&form=6&db=m Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12743579&form=6&db=m Biochemical and clinical evidence that aspirin-intolerant asthmatic subjects tolerate the cyclooxygenase 2-selective analgetic drug celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12796206&form=6&db=m Cyclooxygenase-2 inhibitors in aspirin-sensitive asthma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12861847&form=6&db=m Celecoxib, a highly selective COX-2 inhibitor, is safe in aspirin-induced asthma patients. therapeutic application,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895598&form=6&db=m Cyclooxygenase enzymes in allergic inflammation and asthma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895602&form=6&db=m The DP receptor, allergic inflammation and asthma. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14519044&form=6&db=m Safety of COX-2 inhibitors in asthma patients with aspirin hypersensitivity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552699&form=6&db=m COX-2 specific inhibitors in NSAID-intolerant patients. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561202&form=6&db=m Diagnosis, prevention and treatment of aspirin-induced asthma and rhinitis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14680616&form=6&db=m Adverse respiratory reactions to aspirin and nonsteroidal anti-inflammatory drugs. therapeutic application,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14769263&form=6&db=m Treatment of patients with respiratory reactions to aspirin and nonsteroidal anti-inflammatory drugs. therapeutic application,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15130327&form=6&db=m [Influence of peroxisome proliferator-activated receptor gamma on airway inflammation of guinea pigs with asthma] unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151923&form=6&db=m Higher prostaglandin e2 production by dendritic cells from subjects with asthma compared with normal subjects. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15316498&form=6&db=m Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15480320&form=6&db=m Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15544595&form=6&db=m A functional polymorphism in the promoter region of the cyclooxygenase-2 gene is not associated with asthma and atopy in an Australian population. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15613671&form=6&db=m Aspirin sensitivity: implications for patients with coronary artery disease. therapeutic application,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823178&form=6&db=m Augmentation of allergic inflammation in the airways of cyclooxygenase-2-deficient mice. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15990799&form=6&db=m Association of COX-2 gene haplotypes with prostaglandins production in bronchial asthma. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055872&form=6&db=m Cyclooxygenase-1 gene polymorphisms in patients with different asthma phenotypes and atopy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16583357&form=6&db=m Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16751012&form=6&db=m Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16825866&form=6&db=m Genetic mechanism of aspirin-induced urticaria/angioedema. therapeutic application,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892790&form=6&db=m Safety of etoricoxib, a specific cyclooxygenase-2 inhibitor, in asthmatic patients with aspirin-exacerbated respiratory disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016059&form=6&db=m Safety of meloxicam in aspirin-hypersensitive patients with asthma and/or nasal polyps. A challenge-proven study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030227&form=6&db=m Clinical and pathologic perspectives on aspirin sensitivity and asthma. therapeutic application,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17454003&form=6&db=m Fine mapping of murine asthma quantitative trait loci and analyses of Ptgs1 and Mrc1 as positional candidate genes. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17508965&form=6&db=m PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease. ongoing research,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17508966&form=6&db=m Alternative splicing of cyclooxygenase-1 gene: altered expression in leucocytes from patients with bronchial asthma and association with aspirin-induced 15-HETE release. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17512652&form=6&db=m Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17573729&form=6&db=m Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17608990&form=6&db=m Review of the selective COX-2 inhibitors celecoxib and rofecoxib: focus on clinical aspects. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17672868&form=6&db=m Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962899&form=6&db=m Effects of sulfur dioxide on the expressions of EGF, EGFR, and COX-2 in airway of asthmatic rats. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18053020&form=6&db=m Safety of triflusal (antiplatelet drug) in patients with aspirin-exacerbated respiratory diseases. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18085997&form=6&db=m Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18489027&form=6&db=m Cyclooxygenase-2 gene polymorphisms in an Australian population: association of the -1195G > A promoter polymorphism with mild asthma. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18583575&form=6&db=m Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. causal interaction,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18753249&form=6&db=m COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18769189&form=6&db=m The Asian side of asthma and allergy. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19014484&form=6&db=m An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19134015&form=6&db=m Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19210906&form=6&db=m Aspirin sensitivity and desensitization for asthma and sinusitis. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19342146&form=6&db=m [A cyclooxygenase-2 selective inhibitor worsens respiratory function and enhances mast cell activity in ovalbumin-sensitized mice.] causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19667532&form=6&db=m The protective effects of leukotriene modifiers in aspirininduced asthma. therapeutic application,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19862936&form=6&db=m COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20298280&form=6&db=m Clinical studies of asthma phenotypes focusing on the role of leukotrienes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631417&form=6&db=m Aspirin-induced asthma: a tribute to John Vane as a source of inspiration. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20880055&form=6&db=m Effects of celecoxib on major prostaglandins in asthma. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21703104&form=6&db=m Selective cyclooxygenase-2 inhibitor cross-reactivity in aspirin-exacerbated respiratory disease. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207824&form=6&db=m A review on herbal antiasthmatics. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416915&form=6&db=m Association of the -14C/G MET and the -765G/C COX-2 Gene Polymorphisms with the Risk of Chronic Rhinosinusitis with Nasal Polyps in a Polish Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23140569&form=6&db=m Inflammation, allergy and asthma, complex immune origin diseases: mechanisms and therapeutic agents. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23184151&form=6&db=m Aspirin-Intolerant Asthma: A Comprehensive Review of Biomarkers and Pathophysiology. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23240010&form=6&db=m Signal transduction pathways (MAPKs, NF-?B, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23449692&form=6&db=m COX-2 Inhibits Th9 Differentiation During Allergic Lung Inflammation Via Downregulation of IL-17RB. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23639710&form=6&db=m Mechanisms of aspirin desensitization. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23642096&form=6&db=m Role of Cyclooxygenase-2 in Exacerbation of Allergen-Induced Airway Remodeling by Multiwalled Carbon Nanotubes. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085850&form=6&db=m Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24461582&form=6&db=m Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24556222&form=6&db=m Tinospora cordifolia extract modulates COX-2, iNOS, ICAM-1, pro-inflammatory cytokines and redox status in murine model of asthma. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24768319&form=6&db=m The PGE2-EP2-mast cell axis: An antiasthma mechanism. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25180620&form=6&db=m Cyclooxygenase-2 and microRNA-155 expression are elevated in asthmatic airway smooth muscle cells. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25217662&form=6&db=m MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25590318&form=6&db=m State of the Art: Medical treatment of aspirin exacerbated respiratory disease (AERD). causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25721048&form=6&db=m Genetic variants in TNF?, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. causal interaction,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25936612&form=6&db=m Aspirin-exacerbated respiratory disease: characteristics and management strategies. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26685098&form=6&db=m Cyclooxygenase 2: its regulation, role and impact in airway inflammation. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26941575&form=6&db=m Functional Role of Fc?RIIB in the Regulation of Mesenchymal Stem Cell Function. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27126722&form=6&db=m Update on the Management of Aspirin-Exacerbated Respiratory Disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27188427&form=6&db=m Identifying a biomarker network for corticosteroid resistance in asthma from bronchoalveolar lavage samples. therapeutic application,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27372432&form=6&db=m Selective COX-2 Inhibition Exerts No Negative Effects on Peripheral Blood Lymphocytes in Allergic Asthmatics. therapeutic application,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27538737&form=6&db=m Aspirin-exacerbated respiratory disease and current treatment modalities. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27567328&form=6&db=m Automated identification of an aspirin-exacerbated respiratory disease cohort. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27712767&form=6&db=m Mechanisms of Benefit with Aspirin Therapy in Aspirin-Exacerbated Respiratory Disease. causal interaction,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27719658&form=6&db=m Aspirin Intolerance: Experimental Models for Bed-to-Bench. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27799384&form=6&db=m Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27849653&form=6&db=m The role of aspirin desensitization in the management of aspirin-exacerbated respiratory disease. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28109127&form=6&db=m 1-[(2,3-Dihydro-1-benzofuran-2-yl) methyl]piperazines as novel anti-inflammatory compounds: Synthesis and evaluation on H3 R/H4 R. therapeutic application,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28286156&form=6&db=m Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400178&form=6&db=m Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28859704&form=6&db=m An update on the epidemiology of aspirin-exacerbated respiratory disease. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28859705&form=6&db=m Immunoglobulin G4 sinusitis in association with aspirin-exacerbated respiratory disease. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28949387&form=6&db=m Saponin-enriched extract of Asparagus cochinchinensis alleviates airway inflammation and remodeling in ovalbumin-induced asthma model. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29249187&form=6&db=m An update on the management of aspirin-exacerbated respiratory disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29336282&form=6&db=m Role of group 2 innate lymphocytes in aspirin-exacerbated respiratory disease pathogenesis. causal interaction,unassigned 4,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29890239&form=6&db=m A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. causal interaction,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29967100&form=6&db=m miR-155 Modulates Cockroach Allergen- and Oxidative Stress-Induced Cyclooxygenase-2 in Asthma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081047&form=6&db=m Prostaglandins in asthma and allergic diseases. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231709&form=6&db=m Risk of Acute Asthma Attacks Associated With Nonsteroidal Anti-inflammatory Drugs: A Self-Controlled Case Series. diagnostic usage,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30582489&form=6&db=m Clinical updates in aspirin-exacerbated respiratory disease. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847401&form=6&db=m Computed Tomography Findings in Patients with Samter's Triad: An Observational Study. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31442000&form=6&db=m Longitudinal progression of aspirin-exacerbated respiratory disease: analysis of a national insurance claims database. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31611798&form=6&db=m Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31693796&form=6&db=m Treatment practices for aspirin-exacerbated respiratory disease: analysis of a national insurance claims database. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31918268&form=6&db=m MiRNA-192-5p attenuates airway remodeling and autophagy in asthma by targeting MMP-16 and ATG7. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32182661&form=6&db=m The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32186565&form=6&db=m Investigation of the active components and mechanisms of Schisandra chinensis in the treatment of asthma based on a network pharmacology approach and experimental validation. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32208749&form=6&db=m Symptom Control of Patients With Chronic Rhinosinusitis With Nasal Polyps Under Maintenance Therapy With Daily Acetylsalicylic Acid. therapeutic application,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32299015&form=6&db=m Aspirin-exacerbated respiratory disease. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32371071&form=6&db=m Activation of the 15-lipoxygenase pathway in aspirin-exacerbated respiratory disease. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32596477&form=6&db=m Aspirin-exacerbated respiratory disease: A review. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33336182&form=6&db=m Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33628113&form=6&db=m The Protective Effects of Maresin 1 in the OVA-Induced Asthma Mouse Model. therapeutic application,unassigned 2,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33819512&form=6&db=m Studies of the role of basophils in aspirin-exacerbated respiratory disease pathogenesis. causal interaction,unassigned 3,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305932&form=6&db=m Aspirin Actions in Treatment of NSAID-Exacerbated Respiratory Disease. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34322123&form=6&db=m Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4. unassigned -
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34364538&form=6&db=m Clinical evaluation and diagnosis of aspirin-exacerbated respiratory disease. causal interaction,unassigned 1,0
1.14.99.1 Asthma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429873&form=6&db=m Biomarkers for predicting response to long-term high dose aspirin therapy in aspirin-exacerbated respiratory disease. causal interaction,unassigned 4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2115849&form=6&db=m The cyclooxygenase theory of aspirin-induced asthma. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8386106&form=6&db=m Cysteinyl leukotrienes overproduction and mast cell activation in aspirin-provoked bronchospasm in asthma. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10992560&form=6&db=m The importance of COX-2 inhibition for aspirin induced asthma. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11055820&form=6&db=m COX-2-Specific inhibitors--the emergence of a new class of analgesic and anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11235048&form=6&db=m Successful use of cyclooxygenase-2 inhibitor in a patient with aspirin-induced asthma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11251623&form=6&db=m Safety of a specific COX-2 inhibitor in aspirin-induced asthma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11476469&form=6&db=m Effects of pranlukast on aspirin-induced bronchoconstriction: differences in chemical mediators between aspirin-intolerant and tolerant asthmatic patients. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11678863&form=6&db=m Release of cysteinyl leukotrienes with aspirin stimulation and the effect of prostaglandin E(2) on this release from peripheral blood leucocytes in aspirin-induced asthmatic patients. causal interaction,unassigned 1,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11995251&form=6&db=m [Asthma with aspirin intolerance] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065343&form=6&db=m Safety of a cyclooxygenase-2 inhibitor in patients with aspirin-sensitive asthma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684334&form=6&db=m Cyclooxygenase-2 inhibitors in aspirin-induced asthma. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12861847&form=6&db=m Celecoxib, a highly selective COX-2 inhibitor, is safe in aspirin-induced asthma patients. therapeutic application,unassigned 4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561202&form=6&db=m Diagnosis, prevention and treatment of aspirin-induced asthma and rhinitis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14749606&form=6&db=m Aspirin intolerance and the cyclooxygenase-leukotriene pathways. unassigned -
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136765&form=6&db=m Safety of etoricoxib, a new cyclooxygenase 2 inhibitor, in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505607&form=6&db=m Pathogenesis of nonsteroidal antiinflammatory drug-induced asthma. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016059&form=6&db=m Safety of meloxicam in aspirin-hypersensitive patients with asthma and/or nasal polyps. A challenge-proven study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609236&form=6&db=m Management options for patients with aspirin and nonsteroidal antiinflammatory drug sensitivity. therapeutic application,unassigned 2,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23240010&form=6&db=m Signal transduction pathways (MAPKs, NF-?B, and C/EBP) regulating COX-2 expression in nasal fibroblasts from asthma patients with aspirin intolerance. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Asthma, Aspirin-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441755&form=6&db=m Low Prostaglandin E(2) and Cyclooxygenase Expression in Nasal Mucosa Fibroblasts of Aspirin-Intolerant Asthmatics. causal interaction,unassigned 3,0
1.14.99.1 Asthma, Exercise-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1481179&form=6&db=m Inhaled frusemide and exercise induced asthma: evidence of a role for inhibitory prostanoids. therapeutic application,unassigned 3,0
1.14.99.1 Asthma, Exercise-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8012649&form=6&db=m Asthma in children and ASA intolerance. causal interaction,unassigned 4,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1313776&form=6&db=m [Signal transduction of prostaglandin E2 and thromboxane A2] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8919648&form=6&db=m A comparative study of arachidonic acid metabolism in rabbit cultured astrocytes and human astrocytoma cells (1321N1). ongoing research,unassigned 4,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10483780&form=6&db=m Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10501211&form=6&db=m Signaling mechanisms involved in the activation of arachidonic acid metabolism in human astrocytoma cells by tumor necrosis factor-alpha: phosphorylation of cytosolic phospholipase A2 and transactivation of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389063&form=6&db=m Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15017587&form=6&db=m Cyclooxygenase-2, Bcl-2, and chromosome 1p analysis in protoplasmic astrocytomas. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15088099&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210717&form=6&db=m Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15588680&form=6&db=m Zingansikpoongtang modulates beta-amyloid and IL-1beta-induced cytokine production and cyclooxygenase-2 expression in human astrocytoma cells U373MG. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16482921&form=6&db=m [Expression of cyclooxygenase (COX)-2 in astrocytic tumors and anti-tumor effects of selective COX-2 inhibitors] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16621014&form=6&db=m Microwave-assisted antigen retrieval and incubation with cox-2 antibody of archival paraffin-embedded human oligodendroglioma and astrocytomas. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16868662&form=6&db=m Cyclooxygenase-2 expression in astrocytomas. Relationship with microvascular parameters, angiogenic factors expression and survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17627037&form=6&db=m HIV-1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in astrocytoma cells through a nuclear factor-kappaB-dependent mechanism. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640750&form=6&db=m Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17651055&form=6&db=m Resveratrol inhibits nitric oxide and prostaglandin E2 production by lipopolysaccharide-activated C6 microglia. ongoing research,unassigned 4,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097055&form=6&db=m Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18495209&form=6&db=m Expression of nuclear factor-kappaB in human astrocytomas: relation to pI kappa Ba, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19332096&form=6&db=m Analysis of interleukin (IL)-8 expression in human astrocytomas: Associations with IL-6, cyclooxygenase-2, vascular endothelial growth factor, and microvessel morphometry. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20052522&form=6&db=m Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382140&form=6&db=m mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20847443&form=6&db=m Amyloid-? Induces Cyclooxygenase-2 and PGE2 Release in Human Astrocytes in NF-? B Dependent Manner. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21294088&form=6&db=m Immunohistochemical expression of cycloxygenase-2 in astrocytoma: correlation with angiogenesis, tumor progression and survival. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479220&form=6&db=m Influence of Caloric Restriction on Constitutive Expression of NF-?B in an Experimental Mouse Astrocytoma. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Astrocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22940226&form=6&db=m The effect of guggulipid and nimesulide on MPTP-induced mediators of neuroinflammation in rat astrocytoma cells, C6. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24975555&form=6&db=m Molecular mechanisms of low dose ionizing radiation-induced hormesis, adaptive responses, radioresistance, bystander effects, and genomic instability. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584262&form=6&db=m Cyclooxygenase-2 up-regulates ataxia telangiectasia and Rad3 related through extracellular signal-regulated kinase activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19695440&form=6&db=m Modulation of ionizing radiation-induced G2 arrest by cyclooxygenase-2 and its inhibitor celecoxib. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21765464&form=6&db=m Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells. causal interaction,unassigned 1,0
1.14.99.1 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22417802&form=6&db=m Celecoxib Enhances the Radiosensitizing Effect of 7-Hydroxystaurosporine (UCN-01) in Human Lung Cancer Cell Lines. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539367&form=6&db=m Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Ataxia Telangiectasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=454516&form=6&db=m Anti-inflammatory drugs in experimental atherosclerosis. Part 4. Inhibition of atherosclerosis in vivo and thromboxane synthesis and platelet aggregation in vitro. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1588937&form=6&db=m Atherosclerosis: the eicosanoid connection. ongoing research,unassigned 2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1887929&form=6&db=m Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. therapeutic application,unassigned 2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3149431&form=6&db=m [Defects in the prostaglandin system. VII. (Generalized, inherited [?]) cyclooxygenase defect] causal interaction,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3986018&form=6&db=m Anti-inflammatory drugs in experimental atherosclerosis. Part 6. Combination therapy with steroid and non-steroid agents. causal interaction,unassigned 2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6305345&form=6&db=m Radical acetoacetate oxidation by myeloperoxidase, lactoperoxidase, prostaglandin synthetase, and prostacyclin synthetase: implications for atherosclerosis. therapeutic application,unassigned 2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7620513&form=6&db=m Regulatory mechanisms of the vascular endothelium: an update. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10073969&form=6&db=m Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10397690&form=6&db=m Oxidized low density lipoprotein suppresses expression of inducible cyclooxygenase in human macrophages. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10731924&form=6&db=m Coexpression of cyclooxygenase-2 and matrix metalloproteinases in human aortic atherosclerotic lesions. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10859290&form=6&db=m Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10942685&form=6&db=m Expression of cyclo-oxygenase-2 in human atherosclerotic carotid arteries. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10952950&form=6&db=m Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11209977&form=6&db=m Cyclo-oxygenase products and atherothrombosis. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11248083&form=6&db=m Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316917&form=6&db=m Current oral antiplatelet agents to prevent atherothrombosis. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11472739&form=6&db=m Effects of COX-2 inhibitors on aortic prostacyclin production in cholesterol-fed rabbits. ongoing research,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509060&form=6&db=m Risk of cardiovascular events associated with selective COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11733615&form=6&db=m Cyclooxygenase-2 and atherosclerosis: friend or foe? unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11755922&form=6&db=m Atorvastatin reduces the expression of cyclooxygenase-2 in a rabbit model of atherosclerosis and in cultured vascular smooth muscle cells. ongoing research,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956125&form=6&db=m Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12352013&form=6&db=m Cyclooxygenase-2 and atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12364556&form=6&db=m Tyrosine nitration in prostaglandin H(2) synthase. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12392964&form=6&db=m Arsenic induces peroxynitrite generation and cyclooxygenase-2 protein expression in aortic endothelial cells: possible role in atherosclerosis. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12623129&form=6&db=m Regulation of cyclooxygenase-2 expression by iloprost in human vascular smooth muscle cells. Role of transcription factors CREB and ICER. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626204&form=6&db=m No effect of cyclooxygenase inhibition on plaque size in atherosclerosis-prone mice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12652331&form=6&db=m Suppression of oxidative stress as a mechanism of reduction of hypercholesterolemic atherosclerosis by aspirin. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664583&form=6&db=m Cyclooxygenase-2 in human pathological disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12740008&form=6&db=m Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activated receptor gamma/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767669&form=6&db=m Effects of MF-tricyclic, a selective cyclooxygenase-2 inhibitor, on atherosclerosis progression and susceptibility to cytomegalovirus replication in apolipoprotein-E knockout mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767670&form=6&db=m Cyclooxygenase-2 inhibitors and atherosclerosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14522423&form=6&db=m Chronic inhibition of cyclooxygenase-2 does not alter plaque composition in a mouse model of advanced unstable atherosclerosis. therapeutic application,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14560332&form=6&db=m [Controversies regarding the effects of cyclooxygenase inhibitors on the course and complications of arterial atherosclerosis] causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14638539&form=6&db=m Cyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14642682&form=6&db=m Effect of cyclooxygenase-2 inhibition with rofecoxib on endothelial dysfunction and inflammatory markers in patients with coronary artery disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14987412&form=6&db=m Cyclooxygenase isoforms and atherosclerosis. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15063354&form=6&db=m Cyclooxygenase-2 and inflammation in atherosclerosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15090261&form=6&db=m Anti-atherosclerotic effects of vitamin E--myth or reality? therapeutic application,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15170590&form=6&db=m Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: role in atherosclerosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194006&form=6&db=m Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells. therapeutic application,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218471&form=6&db=m Pharmacologic inhibition of nitric oxide synthases and cyclooxygenases enhances intimal hyperplasia in balloon-injured rat carotid arteries. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15249654&form=6&db=m Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15286460&form=6&db=m Pathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15531779&form=6&db=m Activation of inflammatory mediators and potential role of ah-receptor ligands in foam cell formation. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15576654&form=6&db=m Concurrent treatment with renin-angiotensin system blockers and acetylsalicylic acid reduces nuclear factor kappaB activation and C-reactive protein expression in human carotid artery plaques. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15618071&form=6&db=m Monocyte cyclooxygenase-2 overactivity: a new marker of subclinical atherosclerosis in asymptomatic subjects with cardiovascular risk factors? causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655126&form=6&db=m Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15905461&form=6&db=m COX-2-derived prostacyclin modulates vascular remodeling. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15950196&form=6&db=m Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16040051&form=6&db=m Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16101563&form=6&db=m Monocyte cyclooxygenase-2 activity: a new therapeutic target for atherosclerosis? ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16218482&form=6&db=m COX-2 and prostaglandins in atherosclerosis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16254252&form=6&db=m Cardiovascular complications of non-steroidal anti-inflammatory drugs. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16380543&form=6&db=m Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16399867&form=6&db=m The prostacyclin receptor induces human vascular smooth muscle cell differentiation via the protein kinase A pathway. causal interaction,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16401468&form=6&db=m Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16427740&form=6&db=m CLA isomers inhibit TNFalpha-induced eicosanoid release from human vascular smooth muscle cells via a PPARgamma ligand-like action. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16458279&form=6&db=m Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16519099&form=6&db=m [Selenium and the activities of cyclooxygenase and lipoxygenase in cells involved in atherogenesis] ongoing research,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16626567&form=6&db=m [Cyclooxygenase-2 and atherosclerosis: disputation and prospect] causal interaction,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16640962&form=6&db=m Cyclooxygenase-2 inhibition: vascular inflammation and cardiovascular risk. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785824&form=6&db=m Cyclooxygenase-2 inhibition and coagulation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785826&form=6&db=m COX-2 and atherosclerosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16792983&form=6&db=m [Cyclooxygenase-2: a new therapeutic target in atherosclerosis?] causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16846782&form=6&db=m Oxidative alterations of cyclooxygenase during atherogenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16894405&form=6&db=m Effects of bisphosphonates on prostaglandin E2 and thromboxane B2 production in human whole blood and monocytes stimulated by lipopolysaccharide and A23187. causal interaction,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16998585&form=6&db=m Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17015640&form=6&db=m Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis. ongoing research,unassigned 2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17054845&form=6&db=m [Risk factor assessment of cardiocerebrovascular diseases in patients with rheumatoid arthritis] causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17097036&form=6&db=m Effects of aspirin on atherosclerosis and the cyclooxygenase-2 expression in atherosclerotic rabbits. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17162249&form=6&db=m Age-related changes in monocyte and platelet cyclooxygenase expression in healthy male humans and rats. causal interaction,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17318614&form=6&db=m The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE-/- mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17338677&form=6&db=m Drug-induced immunomodulation to affect the development and progression of atherosclerosis: a new opportunity? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350020&form=6&db=m Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African-Americans: the Atherosclerosis Risk in Communities Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363696&form=6&db=m Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17495879&form=6&db=m Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584067&form=6&db=m COX-2 expression in atherosclerosis: the good, the bad or the ugly? therapeutic application,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17642186&form=6&db=m [Activity of prostaglandin synthetase in human arteries in atherosclerosis (histochemical study)] ongoing research,unassigned 2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17687634&form=6&db=m Role of Sandhika: a polyherbal formulation on MC3T3-E1 osteoblast-like cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17827712&form=6&db=m Distribution profiles of membrane Type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) in rabbit atherosclerosis: comparison with plaque instability analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17853322&form=6&db=m [Antiplatelet therapy can unmask an inherited bleeding disorder. Aspirin-like defect of platelets does not protect against atherosclerosis.] causal interaction,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17950326&form=6&db=m The select cyclooxygenase-2 inhibitor celecoxib reduced the extent of atherosclerosis in apo E-/- mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17993809&form=6&db=m Anti-inflammatory drugs and atherosclerosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18323528&form=6&db=m Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18378239&form=6&db=m Inflammatory and non-invasive vascular markers: the multimarker approach for risk stratification in coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385811&form=6&db=m COX-2 gene promoter polymorphism and coronary artery disease in middle-aged men: the Helsinki sudden death study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18420277&form=6&db=m Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18514659&form=6&db=m Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571731&form=6&db=m WITHDRAWN: Cyclooxygenase and prostaglandin synthases in atherosclerosis: Recent insights and future perspectives. therapeutic application,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18697608&form=6&db=m Antiatherosclerotic activity of ibuprofen, a non-selective COX inhibitor--an animal study. therapeutic application,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18759289&form=6&db=m Chronic arthritis aggravates vascular lesions in rabbits with atherosclerosis: A novel model of atherosclerosis associated with chronic inflammation. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18768181&form=6&db=m Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18948273&form=6&db=m Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19046748&form=6&db=m Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19122175&form=6&db=m Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236624&form=6&db=m Elevated plasma prostaglandins and acetylated histone in monocytes in Type 1 diabetes patients. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19307727&form=6&db=m Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19318593&form=6&db=m Cyclooxygenase-2 induced by zymosan in human-monocyte-derived dendritic cells shows high stability and its expression is enhanced by atorvastatin. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19320776&form=6&db=m Cyclooxygenase Inhibitors Repress Vascular Hyaluronan-Synthesis in Murine Atherosclerosis and Neointimal Thickening. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19332545&form=6&db=m Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis. causal interaction,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19343100&form=6&db=m Cyclooxygenase products and atherosclerosis. causal interaction,unassigned 2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19493461&form=6&db=m Aspirin inhibits tumor necrosis factor-alpha-stimulated fractalkine expression in human umbilical vein endothelial cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19616084&form=6&db=m Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI(3)K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells. causal interaction,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19754418&form=6&db=m Inhibitors of the Microsomal Prostaglandin E(2) Synthase-1 as Alternative to Non Steroidal Anti-inflammatory Drugs (NSAIDs) - A Critical Review. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19779026&form=6&db=m Association of myocardial infarctions with COX-2 inhibition may be related to immunomodulation towards a Th1 response resulting in atheromatous plaque instability: an evidence-based interpretation. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19783781&form=6&db=m Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19920789&form=6&db=m G-765C COX-2 gene promoter polymorphism and risk of atherosclerosis after kidney transplantation. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19926832&form=6&db=m Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192567&form=6&db=m Curcumin: from food spice to cancer prevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332714&form=6&db=m Functional promoter polymorphism of cyclooxygenase-2 modulates the inflammatory response in stable coronary heart disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20477620&form=6&db=m Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20503008&form=6&db=m [The role of platelets in atherosclerosis, diabetes mellitus, and chronic kidney disease. An attempt at explaining the TREAT study results]. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530000&form=6&db=m Targeted deletions of cyclooxygenase-2 and atherogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20538289&form=6&db=m Celecoxib combined with atorvastatin prevents progression of atherosclerosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20550500&form=6&db=m Cyclooxygenase and atherosclerosis: a smoking area. causal interaction,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635093&form=6&db=m Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20675562&form=6&db=m Differential effects on nitric oxide-mediated vasodilation in mesenteric and uterine arteries from cytomegalovirus-infected mice. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20684827&form=6&db=m Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20974241&form=6&db=m Anti-atherogenic effect of San-Huang-Xie-Xin-Tang, a traditional Chinese medicine, in cultured human aortic smooth muscle cells. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21406422&form=6&db=m The ARIC Carotid MRI Study of Blood Cellular Markers: An Inverse Association of Monocyte Myeloperoxidase Content With Peripheral Arterial Disease. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21490773&form=6&db=m Methotrexate in atherogenesis and cholesterol metabolism. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22443285&form=6&db=m Role of Cyclooxygenase 2 and Endothelial Nitric Oxide Synthetase in Preclinical Atherosclerosis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22493243&form=6&db=m Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22551325&form=6&db=m No association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22595400&form=6&db=m Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22746401&form=6&db=m Exposure to diesel exhaust upregulates COX-2 expression in ApoE knockout mice. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23030452&form=6&db=m Cyclooxygenase-2 expression, prostacyclin production and endothelial protection of high-density lipoprotein. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23060635&form=6&db=m Intermittent hypoxia activated cyclooxygenase pathway: role in atherosclerosis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23344731&form=6&db=m Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23907768&form=6&db=m Cyclooxygenase-2 genetic polymorphism and stroke subtypes in chinese. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23969853&form=6&db=m The role of cyclooxygenase-2 on endurance exercise training in female LDL-receptor knockout ovariectomized mice. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23993980&form=6&db=m Mechanisms of aspirin resistance. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24519928&form=6&db=m Cyclooxygenase-2 in Endothelial and Vascular Smooth Muscle Cells Restrains Atherogenesis in Hyperlipidemic Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24856376&form=6&db=m Cyclooxygenase-2 inhibition improves antioxidative defense during experimental hypercholesterolemia. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24859347&form=6&db=m The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24887395&form=6&db=m COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25373619&form=6&db=m Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26026712&form=6&db=m Could the thromboxane A2 pathway be a therapeutic target for the treatment of obstructive sleep apnea-induced atherosclerosis? causal interaction,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26084115&form=6&db=m Hypolipidemic effects of nimesulide and celecoxib in experimentally induced hypercholesterolemia in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303299&form=6&db=m G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity. therapeutic application,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26940257&form=6&db=m Celecoxib for the treatment of atherosclerosis. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27440004&form=6&db=m Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28194409&form=6&db=m A Variant in COX-2 Gene Is Associated with Left Main Coronary Artery Disease and Clinical Outcomes of Coronary Artery Bypass Grafting. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28770648&form=6&db=m Effect of uric acid on inflammatory COX-2 and ROS pathways in vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29384693&form=6&db=m Palmitate Induces Glycosylation of Cyclooxygenase-2 in Primary Human Vascular Smooth Muscle Cells. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29420356&form=6&db=m Dose-Effect of Irbesartan on Cyclooxygenase-2 and Matrix Metalloproteinase-9 Expression in Rabbit Atherosclerosis. ongoing research,unassigned 2,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29756563&form=6&db=m Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30011214&form=6&db=m Complexes of Indomethacin with 4-Carbomethoxy-pyrrolidone PAMAM Dendrimers Show Improved Anti-inflammatory Properties and Temperature-Dependent Binding and Release Profile. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31165994&form=6&db=m Association of COX2 -765G>C promoter polymorphism and coronary artery disease in Korean population. causal interaction,unassigned 4,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31735164&form=6&db=m Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802132&form=6&db=m Enhancing and Complementary Mechanisms of Synergistic Action of Acori Tatarinowii Rhizoma and Codonopsis Radix for Alzheimer's Disease Based on Systems Pharmacology. therapeutic application,unassigned 1,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32821730&form=6&db=m Curcumin Attenuates Acrolein-induced COX-2 Expression and Prostaglandin Production in Human Umbilical Vein Endothelial Cells. causal interaction,unassigned 3,0
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825589&form=6&db=m Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33741600&form=6&db=m Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation. unassigned -
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33915511&form=6&db=m Two Cu(II) coordination polymers: Heterogeneous catalytic Knoevenagel condensation reaction and treatment activity on atherosclerosis via regulating the expression of the COX-2 in vascular endothelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1
1.14.99.1 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33974977&form=6&db=m Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1
1.14.99.1 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259748&form=6&db=m Platelet activation and lipid peroxidation in patients with acute ischemic stroke. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16479190&form=6&db=m The COX-2 G/C -765 polymorphism may modulate the occurrence of cerebrovascular ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22108833&form=6&db=m Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24460806&form=6&db=m Celecoxib-induced change in atrial electrophysiologic substrate in arthritis patients. therapeutic application,unassigned 3,0
1.14.99.1 Atrial Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748877&form=6&db=m Cardiovascular risks associated with non-aspirin non-steroidal anti-inflammatory drug use. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1859517&form=6&db=m Anti-inflammatory and immunomodulating effects of the novel agent gamma-(2-aminoethylamino)-2-butyrothienone. 1st communication: inhibitory effects on mouse paw edema. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6419236&form=6&db=m Augmentation of 12-lipoxygenase activity of lymph node and spleen T cells in autoimmune mice MRL/1. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16418805&form=6&db=m COX-2 Inhibitors Modulate IL-12 Signaling Through JAK-STAT Pathway Leading to Th1 Response in Experimental Allergic Encephalomyelitis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062883&form=6&db=m Expression of cyclooxygenase-2 in orbital fibroadipose connective tissues of Graves' ophthalmopathy patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19886038&form=6&db=m Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20819509&form=6&db=m Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469360&form=6&db=m Association between cyclooxygenase-2 gene polymorphisms and head and neck squamous cell carcinoma risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29351170&form=6&db=m Risk of preterm birth following late pregnancy exposure to NSAIDs or COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29756563&form=6&db=m Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Autoimmune Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117381&form=6&db=m Non-Transcriptional and Translational Function of Canonical NF-?B Signaling in Activating ERK1/2 in IL-1?-Induced COX-2 Expression in Synovial Fibroblasts. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Axial Spondyloarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26186173&form=6&db=m Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis). causal interaction,unassigned 2,0
1.14.99.1 Axial Spondyloarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26834216&form=6&db=m Nonsteroidal Antiinflammatory Drugs for Axial Spondyloarthritis: A Cochrane Review. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Axial Spondyloarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28626213&form=6&db=m The Efficacy of Imrecoxib and Celecoxib in Axial Spondyloarthritis and Their Influence on Serum Dickopff-Related Protein 1 (DKK-1) Levels. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Azotemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7033849&form=6&db=m Indomethacin-induced azotaemia and hyperkalaemia: a case study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Azotemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18797164&form=6&db=m Effect of Exercise on Cardiac Tissue Oxidative and Inflammatory Mediators in Chronic Kidney Disease. ongoing research,unassigned 1,0
1.14.99.1 Azotemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19420110&form=6&db=m NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE. causal interaction,unassigned 2,0
1.14.99.1 Azotemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19656915&form=6&db=m Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney. causal interaction,unassigned 1,0
1.14.99.1 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3093772&form=6&db=m Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7743370&form=6&db=m Differential microvascular response to cyclooxygenase blockade in the rat small intestine during acute bacteremia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8769813&form=6&db=m Bidirectional effects of hepatic ischemia/reperfusion on E. coli-induced TNF-alpha gene expression. ongoing research,unassigned 1,0
1.14.99.1 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21967897&form=6&db=m Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743193&form=6&db=m Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Bacteremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26440613&form=6&db=m The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8453676&form=6&db=m Accelerated hematopoietic recovery and protective effect of the cyclooxygenase inhibitor indomethacin in bacterial infection of neutropenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10225537&form=6&db=m Specific COX-2 inhibitors in arthritis, oncology, and beyond: where is the science headed? causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11231344&form=6&db=m Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12524534&form=6&db=m Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12555215&form=6&db=m Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15879708&form=6&db=m Attenuation of extracellular acidic pH-induced cyclooxygenase-2 expression by nitric oxide. causal interaction,unassigned 4,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19012035&form=6&db=m Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis. causal interaction,unassigned 3,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19694605&form=6&db=m Chitosomes loaded with cranberry proanthocyanidins attenuate the bacterial lipopolysaccharide-induced expression of iNOS and COX-2 in raw 264.7 macrophages. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20038921&form=6&db=m Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS. causal interaction,unassigned 2,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717114&form=6&db=m Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20971925&form=6&db=m Cyclooxygenase-2 Enhances Antimicrobial Peptide Expression and Killing of Staphylococcus aureus. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118574&form=6&db=m Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cells. causal interaction,unassigned 2,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22218775&form=6&db=m The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808144&form=6&db=m Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27631977&form=6&db=m Cytosolic and Calcium-Independent Phospholipases A2 Activation and Prostaglandins E2 Are Associated with Escherichia coli-Induced Reduction of Insulin Secretion in INS-1E Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27682182&form=6&db=m Beneficial Effects of Exogenous Melatonin in Acute Staphylococcus aureus and Escherichia coli Infection-Induced Inflammation and Associated Behavioral Response in Mice After Exposure to Short Photoperiod. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366713&form=6&db=m Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Bacterial Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33356849&form=6&db=m Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria. causal interaction,unassigned 1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679948&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10445576&form=6&db=m Cyclooxygenase-2 in Barrett's esophagus, Barrett's adenocarcinomas, and esophageal SCC: ready for clinical trials. therapeutic application,unassigned 1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10702199&form=6&db=m Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059772&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316217&form=6&db=m Cyclooxygenase-2 expression in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11330414&form=6&db=m Cyclooxygenase-2 expression in Barrett's esophagus. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11783060&form=6&db=m [A study on cyclooxygenase-2 protein expression in esophageal carcinoma and premalignant lesions] causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11904306&form=6&db=m Cyclooxygenase-2 inhibitor therapy for the prevention of esophageal adenocarcinoma in Barrett's esophagus. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11904314&form=6&db=m The effect of selective cyclooxygenase-2 inhibition in Barrett's esophagus epithelium: an in vitro study. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11910360&form=6&db=m Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12055587&form=6&db=m Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060038&form=6&db=m Angiogenic markers, neovascularization and malignant deformation of Barrett's esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12105834&form=6&db=m Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12121879&form=6&db=m Acid- and bile-induced PGE(2) release and hyperproliferation in Barrett's esophagus are COX-2 and PKC-epsilon dependent. unassigned -
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12478242&form=6&db=m Does chemoprevention of Barrett's esophagus using acid suppression and/or COX-2 inhibition prevent neoplastic progression? therapeutic application,unassigned 1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12893070&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in premalignant and malignant esophageal glandular and squamous lesions in Cixian, China. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552327&form=6&db=m COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14629099&form=6&db=m Barrett's esophagus: chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14631367&form=6&db=m Phenotypic differences between esophageal and gastric intestinal metaplasia. unassigned -
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14641306&form=6&db=m Chemoprevention for Barrett's esophagus trial. Design and outcome measures. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14765307&form=6&db=m Gastroesophageal reflux disease and Barrett's esophagus. unassigned -
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15045933&form=6&db=m [Barrett's esophageal adenocarcinoma] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102519&form=6&db=m Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231484&form=6&db=m Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252927&form=6&db=m COX-2 inhibition in upper aerodigestive tract tumors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15269153&form=6&db=m Gastrin-induced cyclooxygenase-2 expression in Barrett's carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15387324&form=6&db=m Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585388&form=6&db=m Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15807268&form=6&db=m [The clinical, pathological features and expression of Ki-67 and COX-2 in severe reflux esophagitis and Barrett's esophagus] diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15887151&form=6&db=m Advances in Barrett's esophagus and esophageal adenocarcinoma. therapeutic application,unassigned 4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247189&form=6&db=m Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16492917&form=6&db=m Effect of acid suppression on molecular predictors for esophageal cancer. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16521222&form=6&db=m Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550596&form=6&db=m Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16682957&form=6&db=m Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16863546&form=6&db=m Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagus. causal interaction,unassigned 3,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17023971&form=6&db=m Barrett's esophagus. causal interaction,unassigned 4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17031101&form=6&db=m Gastroesophageal reflux disease. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17307036&form=6&db=m COX-2, CDX2, and CDC2 immunohistochemical assessment for dysplasia-carcinoma progression in Barrett's esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17509125&form=6&db=m Effect of celecoxib on cyclooxygenase-2 expression and possible variants in a patient with Barrett's esophagus. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17565646&form=6&db=m Predictors for squamous re-epithelialization of Barrett's esophagus after endoscopic biopsy. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17619937&form=6&db=m COX-2 mRNA expression is significantly increased in acid-exposed compared to nonexposed squamous epithelium in gastroesophageal reflux disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17763959&form=6&db=m Effect of adiponectin and ghrelin on apoptosis of Barrett adenocarcinoma cell line. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934641&form=6&db=m Over-expression of cyclooxygenase-2 in endoscopic biopsies of ectopic gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159596&form=6&db=m Sulindac prevents esophageal adenocarcinomas induced by gastroduodenal reflux in rats. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18289358&form=6&db=m REG Ialpha protein expression in Barrett's esophagus. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18349295&form=6&db=m Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Gene Polymorphisms and Risk of Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18783518&form=6&db=m Helicobacter pylori and non-malignant diseases. therapeutic application,unassigned 1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19120900&form=6&db=m What is the clinical significance of stromal angiogenesis in Barrett's esophagus? causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19830863&form=6&db=m [Chemoprevention of Barrett's esophagus by celecoxib in rats.] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,4
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20814068&form=6&db=m Cyclooxygenase-2 (COX-2) is the key event in pathophysiology of Barrett's esophagus. Lesson from experimental animal model and human subjects. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21325951&form=6&db=m Fatty Acid Synthase Expression in Barrett's Esophagus: Implications for Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21359892&form=6&db=m Comparison of COX-2, Ki-67, and BCL-2 expression in normal esophageal mucosa, Barrett's esophagus, dysplasia, and adenocarcinoma with postablation mucosa and implications for ablative therapies. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21853395&form=6&db=m Reply to Letter to the Editor: Re: Comparison of COX-2, Ki-67, and BCL-2 expression in normal esophageal mucosa, Barrett's esophagus, dysplasia, and adenocarcinoma with postablation mucosa and implications for ablative therapies (Online First). therapeutic application,unassigned 1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22081106&form=6&db=m Cyclooxygenase-2 expression in esophageal epithelium before and after photodynamic therapy for Barrett's esophagus with high-grade dysplasia or intramucosal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22147251&form=6&db=m Increased Expression of VEGF, COX-2, and Ki-67 in Barrett's Esophagus: Does the Length Matter? unassigned -
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22591041&form=6&db=m Evaluation of Barrett's esophagus with CK7, CK20, p53, Ki67, and cyclooxygenase expressions using chromoendoscopical examination. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22667343&form=6&db=m Immunohistochemical study of cyclooxygenase-2 in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23002358&form=6&db=m Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23955118&form=6&db=m Toll-like receptor 4 activation in Barrett's esophagus results in a strong increase in COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24357184&form=6&db=m Cyclooxygenase-2 and Inflammation Mediators Have a Crucial Role in Reflux-Related Esophageal Histological Changes and Barrett's Esophagus. causal interaction,unassigned 1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24651385&form=6&db=m Cyclooxygenase inhibitors use is associated with reduced risk of esophageal adenocarcinoma in patients with Barrett's esophagus: a meta-analysis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681073&form=6&db=m Preference of Endoscopic Ablation Over Medical Prevention of Esophageal Adenocarcinoma by Patients with Barrett's Esophagus. therapeutic application,unassigned 2,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25185658&form=6&db=m Esophageal COX-2 expression is increased in Barrett's esophagus, obesity, and smoking. causal interaction,unassigned 4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25266020&form=6&db=m Strategy for prevention of cancers of the esophagus. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25427631&form=6&db=m Guggulsterone, a plant-derived inhibitor of NF-TB, suppresses CDX2 and COX-2 expression and reduces the viability of esophageal adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31928220&form=6&db=m Interaction of epidermal growth factor with COX-2 products and peroxisome proliferator-activated receptor-? system in experimental rat Barrett's esophagus. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Barrett Esophagus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441691&form=6&db=m Lipid droplet biogenesis and COX-2 pathway activation are triggered by Barrett's esophagus and adenocarcinoma, but not esophageal squamous cell carcinoma risk factors. unassigned -
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=96139&form=6&db=m The kallikrein-kinin system in Bartter's syndrome and its response to prostaglandin synthetase inhibition. therapeutic application,unassigned 2,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=119300&form=6&db=m Effect of Sar1-ala8-angiotensin II on blood pressure and renin in Bartter's syndrome, before and after treatment with prostaglandin synthetase inhibitors. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=333946&form=6&db=m Prostaglandins and the kidney. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=412983&form=6&db=m Prostaglandin synthetase inhibitors in Bartter's syndrome. Effect on immunoreactive prostaglandin E excretion. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=415668&form=6&db=m Treatment of Bartter's syndrome in early childhood with prostaglandin synthetase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=440896&form=6&db=m Long-term use of propranolol, ibuprofen, and spironolactone in the management of Bartter's syndrome. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3153013&form=6&db=m Growth from birth to adulthood in a patient with the neonatal form of Bartter syndrome. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6171004&form=6&db=m Bartter's syndrome: physiological and pharmacological studies. causal interaction,unassigned 4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6433438&form=6&db=m Effects of prostaglandin synthetase inhibition on captopril-induced changes in renal function in Bartter's syndrome. ongoing research,unassigned 4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6767392&form=6&db=m Treatment of Bartter's syndrome with indomethacin. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6785370&form=6&db=m Plasma "prorenin"-renin in Bartter's syndrome, cystic fibrosis, and chloride deficiency, and the effect of prostaglandin synthetase inhibition. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6787547&form=6&db=m Effect of treatment with prostaglandin synthetase inhibitors on the erythrocyte sodium transport abnormality of Bartter's syndrome. therapeutic application,unassigned 4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7020264&form=6&db=m [Clinical findings, pathogenesis and treatment of Bartter's syndrome (author's transl)] causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11673754&form=6&db=m Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide. therapeutic application,unassigned 4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12081585&form=6&db=m Role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome. therapeutic application,unassigned 1,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12749662&form=6&db=m Successful management of an extreme example of neonatal hyperprostaglandin-E syndrome (Bartter's syndrome) with the new cyclooxygenase-2 inhibitor rofecoxib. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14630996&form=6&db=m Induction of microsomal prostaglandin E2 synthase in the macula densa in children with hypokalemic salt-losing tubulopathies. unassigned -
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27786004&form=6&db=m Effects of Prostaglandin Synthetase Inhibitation on Captopril-Induced Changes in Renal Function in Bartter's Syndrome. ongoing research,unassigned 4,0
1.14.99.1 Bartter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30426218&form=6&db=m Effect of nonsteroidal anti-inflammatory drugs in children with Bartter syndrome. causal interaction,unassigned 3,0
1.14.99.1 Basal Cell Nevus Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038018&form=6&db=m Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Bernard-Soulier Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14602548&form=6&db=m Platelet function tests using platelet aggregometry: need for repetition of the test for diagnosis of defective platelet function. diagnostic usage,unassigned 3,0
1.14.99.1 Bile Duct Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584358&form=6&db=m Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Bile Duct Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161010&form=6&db=m Different expression of cyclooxygenase-2 in biliary epithelia of bile duct cancer with or without pancreaticobiliary maljunction. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Bile Duct Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16361272&form=6&db=m Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Bile Duct Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16755536&form=6&db=m Resampling-based multiple hypothesis testing procedures for genetic case-control association studies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Bile Duct Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20740367&form=6&db=m Protease-activated receptor-2 regulates cyclooxygenase-2 expression in human bile duct cancer via the pathways of mitogen-activated protein kinases and nuclear factor kappa B. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Bile Duct Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34392440&form=6&db=m Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Bile Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11728233&form=6&db=m The treatment, management and prevention of oesophageal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Bile Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16082585&form=6&db=m Elevated cyclooxygenase-2 expression in patients with early gastric cancer in the gastric pylorus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Bile Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18775915&form=6&db=m Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Bile Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19390968&form=6&db=m Laparotomy Attenuates Lipopolysaccharide-Induced Gastric Bleeding in the Rat. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Biliary Atresia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20084600&form=6&db=m Cyclooxygenase-2 Overexpression is Associated with Clinical Outcome in Biliary Atresia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Biliary Tract Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16361272&form=6&db=m Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Biliary Tract Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16755536&form=6&db=m Resampling-based multiple hypothesis testing procedures for genetic case-control association studies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Biliary Tract Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17575102&form=6&db=m Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Biliary Tract Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159174&form=6&db=m [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Blast Crisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19506164&form=6&db=m Predictors of primary imatinib resistance in chronic myelogenous leukemia are distinct from those in secondary imatinib resistance. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Blindness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24458713&form=6&db=m Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. therapeutic application,unassigned 1,0
1.14.99.1 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1998563&form=6&db=m Indomethacin inhibition of middle ear bone resorption. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3018086&form=6&db=m Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis. causal interaction,unassigned 1,0
1.14.99.1 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8352483&form=6&db=m Experimental otitis media with effusion induced by platelet activating factor. unassigned -
1.14.99.1 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11772972&form=6&db=m Blisters in the small intestinal mucosa of coeliac patients contain T cells positive for cyclooxygenase 2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19636412&form=6&db=m CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24638056&form=6&db=m Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Blister http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28973427&form=6&db=m Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure. causal interaction,unassigned 3,0
1.14.99.1 Blood Platelet Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3920834&form=6&db=m [Genetic defects of prostaglandin and thromboxane synthesis] causal interaction,unassigned 1,0
1.14.99.1 Bone Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009007&form=6&db=m Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Bone Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437166&form=6&db=m Celecoxib prevents juxta-articular osteopenia and growth plate destruction adjacent to inflamed joints in rats with collagen-induced arthritis. ongoing research,unassigned 4,0
1.14.99.1 Bone Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17579086&form=6&db=m Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Bone Diseases, Metabolic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25075626&form=6&db=m Chitooligosaccharides prevent osteopenia by promoting bone formation and suppressing bone resorption in ovariectomised rats: possible involvement of COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499278&form=6&db=m Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715386&form=6&db=m Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Bone Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16032450&form=6&db=m Analgesic effects of nonsteroidal antiinflammatory drugs, acetaminophen, and morphine in a mouse model of bone cancer pain. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=117884&form=6&db=m A cat model for the evaluation of mechanisms of bone resorption: induction of bone loss by simulated immune complexes and inhibition by indomethacin. therapeutic application,unassigned 3,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1615762&form=6&db=m Prostaglandin E2 promotes osteoclast formation in murine hematopoietic cultures through an action on hematopoietic cells. causal interaction,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1998563&form=6&db=m Indomethacin inhibition of middle ear bone resorption. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3003159&form=6&db=m Humoral hypercalcemia of malignancy. Release of a prostaglandin-stimulating bone-resorbing factor in vitro by human transitional-cell carcinoma cells. causal interaction,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3081643&form=6&db=m Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro. unassigned -
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3085891&form=6&db=m Effects of prostacyclin and prostaglandin E1 (PGE1) on bone resorption in the presence and absence of parathyroid hormone. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3293993&form=6&db=m Use of minoxidil to demonstrate that prostacyclin is not the mediator of bone resorption stimulated by growth factors in mouse calvariae. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3501679&form=6&db=m Bone resorption in experimental otosclerosis in rats. causal interaction,unassigned 4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6219580&form=6&db=m Therapy of malignancy-associated hypercalcemia: 1983. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6291729&form=6&db=m Effect of streptococcal cell wall components on bone metabolism in vitro. therapeutic application,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6786343&form=6&db=m Cyclooxygenase products of arachidonic acid metabolism by mouse bone in organ culture. unassigned -
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6966568&form=6&db=m Direct stimulation of bone resorption by epidermal growth factor. ongoing research,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7054120&form=6&db=m N-acetyl muramyl dipeptide stimulation of bone resorption in tissue culture. therapeutic application,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7635987&form=6&db=m Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor. therapeutic application,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8030434&form=6&db=m Phorbol myristate acetate stimulates osteoclast formation in 1 alpha,25-dihydroxyvitamin D3-primed mouse embryonic calvarial cells by a prostaglandin-dependent mechanism. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8109835&form=6&db=m Cyclooxygenase inhibitors vary widely in potency for preventing cytokine-induced bone resorption. therapeutic application,unassigned 4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8852946&form=6&db=m Interleukin-4 inhibits prostaglandin G/H synthase-2 and cytosolic phospholipase A2 induction in neonatal mouse parietal bone cultures. therapeutic application,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9592034&form=6&db=m Bone resorption induced by A23187 is abolished by indomethacin: implications for second messenger utilised by parathyroid hormone. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831332&form=6&db=m Possible background mechanisms of the effectiveness of cyclooxygenase-2 inhibitors in the treatment of rheumatoid arthritis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10199562&form=6&db=m Interleukin-1 alpha induced cyclooxygenase-2 expression in bone-derived endothelial cells. causal interaction,unassigned 3,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10631313&form=6&db=m Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. ongoing research,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10727451&form=6&db=m Prostaglandin G/H synthase-2 is required for maximal formation of osteoclast-like cells in culture. unassigned -
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10750561&form=6&db=m Direct and indirect actions of fibroblast growth factor 2 on osteoclastic bone resorption in cultures. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11079466&form=6&db=m Regulation of cyclooxygenase-2 expression in human osteoblastic cells by N-acetylcysteine. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11708802&form=6&db=m Inhibition of angiogenesis by humulone, a bitter acid from beer hop. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11741978&form=6&db=m Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10. unassigned -
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853703&form=6&db=m Effects of a selective cyclooxygenase-2 inhibitor, celecoxib, on bone resorption and osteoclastogenesis in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12067102&form=6&db=m Inhibitory effect of Carthamus tinctorius L. seed extracts on bone resorption mediated by tyrosine kinase, COX-2 (cyclooxygenase) and PG (prostaglandin) E2. unassigned -
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12120711&form=6&db=m Sequential expressions of MMP-1, TIMP-1, IL-6, and COX-2 genes in induced periapical lesions in rats. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12813861&form=6&db=m Role of cyclooxygenase-2 in bone resorption. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15121014&form=6&db=m Stimulation of cAMP production and cyclooxygenase-2 by prostaglandin E(2) and selective prostaglandin receptor agonists in murine osteoblastic cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15275861&form=6&db=m Immuno-localization of COX-1 and COX-2 in the rat molar periodontal tissue after topical application of lipopolysaccharide. causal interaction,unassigned 4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313472&form=6&db=m Effects of TGF-beta, TNF-alpha, IL-beta and IL-6 alone or in combination, and tyrosine kinase inhibitor on cyclooxygenase expression, prostaglandin E2 production and bone resorption in mouse calvarial bone cells. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16018763&form=6&db=m Interleukin-1beta-induced prostaglandin E2 production by human gingival fibroblasts is upregulated by glycine. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16229354&form=6&db=m Selective cyclooxygenase-2 inhibition prevents bone resorption. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16473054&form=6&db=m Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489006&form=6&db=m Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16513308&form=6&db=m Herbal formulation, Yukmi-jihang-tang-Jahage, regulates bone resorption by inhibition of phosphorylation mediated by tyrosine kinase Src and cyclooxygenase expression. unassigned -
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16612568&form=6&db=m Substance P stimulates release of RANKL via COX-2 expression in human dental pulp cells. ongoing research,unassigned 4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16758505&form=6&db=m Prostaglandin production by human osteoclasts in culture. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,3
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17072738&form=6&db=m Short-term supplementation of COX-2 inhibitor suppresses bone turnover in gonad-intact middle-aged male rats. therapeutic application,unassigned 2,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17347553&form=6&db=m The selective cyclooxygenase-2 inhibitor celecoxib reduces bone resorption, but not bone formation, in ovariectomized mice in vivo. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17352658&form=6&db=m Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17368333&form=6&db=m The role of cyclooxygenase-2 (COX-2) in inflammatory bone resorption. unassigned -
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17573069&form=6&db=m Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis. therapeutic application,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17600534&form=6&db=m Omega-3 fatty acid regulates inflammatory cytokine/mediator messenger RNA expression in Porphyromonas gingivalis-induced experimental periodontal disease. ongoing research,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18088065&form=6&db=m Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18231633&form=6&db=m Feedback Control of the Arachidonate Cascade in Osteoblastic Cells by 15-deoxy-Delta-Prostaglandin J(2). therapeutic application,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18301970&form=6&db=m Selective cyclooxygenase-2 inhibitor prevents reduction of trabecular bone mass in collagen-induced arthritic mice in association with suppression of RANKL/OPG ratio and IL-6 mRNA expression in synovial tissues but not in bone marrow cells. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18431039&form=6&db=m Pharmacological topics of bone metabolism: a novel bisphosphonate for the treatment of periodontitis. therapeutic application,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19198759&form=6&db=m The effect of selective cyclooxygenase-2 inhibitor on human osteoclast precursors to influence osteoclastogenesis in vitro. causal interaction,unassigned 2,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21939752&form=6&db=m Porphyromonas gingivalis induces RANKL in bone marrow stromal cells: involvement of the p38 MAPK. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266364&form=6&db=m Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22548186&form=6&db=m Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide. unassigned -
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22816774&form=6&db=m The growth and osteoclastogenic effects of fibroblasts isolated from keratocystic odontogenic tumor. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23483440&form=6&db=m Topically Applied Phospho-Sulindac Hydrogel is Efficacious and Safe in the Treatment of Experimental Arthritis in Rats. ongoing research,unassigned 4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24472266&form=6&db=m Celecoxib, a selective cyclooxygenase-2 inhibitor, reduces level of a bone resorption marker in postmenopausal women with rheumatoid arthritis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25075626&form=6&db=m Chitooligosaccharides prevent osteopenia by promoting bone formation and suppressing bone resorption in ovariectomised rats: possible involvement of COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25620693&form=6&db=m Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27725865&form=6&db=m Follicle-stimulating hormone enhances alveolar bone resorption via upregulation of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28298360&form=6&db=m Stimulation of Fibroblast Growth Factor 23 by Metabolic Acidosis Requires Osteoblastic Intracellular Calcium Signaling and Prostaglandin Synthesis. causal interaction,unassigned 4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29287688&form=6&db=m Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats. causal interaction,unassigned 3,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29761497&form=6&db=m Vibration enhances PGE2 , IL-6, and IL-8 expression in compressed hPDL cells via cyclooxygenase pathway. causal interaction,unassigned 1,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640491&form=6&db=m Effect of environmental tobacco smoke on COX-2 and SHP-2 expression in a periodontitis rat model. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33403674&form=6&db=m Celecoxib treatment dampens LPS-induced periapical bone resorption in a mouse model. therapeutic application,unassigned 4,0
1.14.99.1 Bone Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34396788&form=6&db=m Metabolic acidosis regulates RGS16 and G protein signaling in osteoblasts. ongoing research,unassigned 1,0
1.14.99.1 Borna Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10078970&form=6&db=m Upregulation of COX-2 and CGRP expression in resident cells of the Borna disease virus-infected brain is dependent upon inflammation. causal interaction,unassigned 4,0
1.14.99.1 Borrelia Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438879&form=6&db=m Arthritis develops but fails to resolve during inhibition of cyclooxygenase 2 in a murine model of Lyme disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Boutonneuse Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22522044&form=6&db=m Regulation of inducible heme oxygenase and cyclooxygenase isozymes in a mouse model of spotted fever group rickettsiosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Bowen's Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401676&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in skin cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Bowen's Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15327557&form=6&db=m Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Bowen's Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16700663&form=6&db=m Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Bowen's Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17497299&form=6&db=m Expression of p63 and cyclooxygenase-2 and their correlation in skin tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Bowen's Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460857&form=6&db=m Epithelial to mesenchymal transition in cutaneous squamous cell carcinoma is correlated with COX-2 expression but not with the presence of stromal macrophages or CD10-expressing cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Bowen's Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22667343&form=6&db=m Immunohistochemical study of cyclooxygenase-2 in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3116626&form=6&db=m Direct and indirect effects of leukotriene D4 on the lungs of unanesthetized sheep. causal interaction,unassigned 2,0
1.14.99.1 Bradycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6807698&form=6&db=m Reversal of bradykinin-induced reflex tachycardia to bradycardia by captopril; evidence for prostacyclin involvement. therapeutic application,unassigned 2,0
1.14.99.1 Brain Concussion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29792868&form=6&db=m AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats. unassigned -
1.14.99.1 Brain Contusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12482118&form=6&db=m Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Brain Contusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19558208&form=6&db=m Prior ethanol injection promotes brain edema after traumatic brain injury: evidence for poor prognosis for intoxicated patients. causal interaction,unassigned 3,0
1.14.99.1 Brain Damage, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25888969&form=6&db=m Hippocampal neuronal cyclooxygenase-2 downstream signaling imbalance in a rat model of chronic aluminium gluconate administration. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Death http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24320706&form=6&db=m Brain death increases COX-1 and COX-2 expression in the renal medulla in a pig model. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9724813&form=6&db=m Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121536&form=6&db=m Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,1
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11739606&form=6&db=m Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15122707&form=6&db=m Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. causal interaction,unassigned 2,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15453089&form=6&db=m Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. therapeutic application,unassigned 1,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612048&form=6&db=m Role of COX-2 in inflammatory and degenerative brain diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17976544&form=6&db=m Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and disruption of the blood-brain barrier. causal interaction,unassigned 3,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18195459&form=6&db=m Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. causal interaction,unassigned 4,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18481165&form=6&db=m Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19343233&form=6&db=m Cyclooxygenase in epilepsy: from perception to application. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24381603&form=6&db=m The selective cyclooxygenase-2 inhibitor, the compound 11b improves haloperidol induced catatonia by enhancing the striatum dopaminergic neurotransmission. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701797&form=6&db=m Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27580512&form=6&db=m Role of cyclooxygenase isoforms in encephalopathy of cirrhotic rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28458341&form=6&db=m The Role of mPGES-1 in Inflammatory Brain Diseases. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396759&form=6&db=m In vivo evaluation of [11C]TMI, a COX-2 selective PET tracer, in baboons. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Brain Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1926236&form=6&db=m Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154040&form=6&db=m Arachidonic acid metabolite production following focal cerebral ischemia: time course and effect of meclofenamate. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2505409&form=6&db=m Effect of MCI-186 on brain edema in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3126075&form=6&db=m Effects of cyclooxygenase and lipoxygenase inhibitors on cerebral edema induced by freezing lesions in rats. ongoing research,unassigned 3,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3964837&form=6&db=m Alterations of the eicosanoid synthetic capacity of rat brain microvessels following ischemia: relevance to ischemic brain edema. causal interaction,unassigned 4,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6309072&form=6&db=m Induction of brain edema following intracerebral injection of arachidonic acid. therapeutic application,unassigned 1,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8666054&form=6&db=m Effect of KBT-3022, a new cyclooxygenase inhibitor, on experimental brain edema in vitro and in vivo. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10636620&form=6&db=m Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11368948&form=6&db=m Inducible cyclooxygenase-2 expression after experimental intracerebral hemorrhage. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576462&form=6&db=m Microglia cyclooxygenase-2 activity in experimental gliomas: possible role in cerebral edema formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16223182&form=6&db=m [A case report of chemotherapy with thalidomide, celecoxib and gemcitabine in the treatment of patients with brain metastases from lung cancer] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17854901&form=6&db=m Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats. causal interaction,unassigned 1,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952743&form=6&db=m Expression of Cyclooxygenase-2 and Its Correlation with Vasogenic Brain Edema in Human Intracranial Meningiomas. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19558208&form=6&db=m Prior ethanol injection promotes brain edema after traumatic brain injury: evidence for poor prognosis for intoxicated patients. causal interaction,unassigned 3,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19628811&form=6&db=m Cyclo-oxygenase-2 mediates hyperbaric oxygen preconditioning-induced neuroprotection in the mouse model of surgical brain injury. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20052522&form=6&db=m Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21725746&form=6&db=m The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120639&form=6&db=m Progesterone protects blood-brain barrier function and improves neurological outcome following traumatic brain injury in rats. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25782468&form=6&db=m Receptor for advanced glycation end-product antagonist reduces blood-brain barrier damage after intracerebral hemorrhage. causal interaction,unassigned 2,0
1.14.99.1 Brain Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28286182&form=6&db=m Crotalus helleri venom preconditioning reduces postoperative cerebral edema and improves neurological outcomes after surgical brain injury. causal interaction,unassigned 3,0
1.14.99.1 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18992713&form=6&db=m The obligatory role of COX-2 expression for induction of HO-1 in ischemic preconditioned rat brain. therapeutic application,unassigned 2,0
1.14.99.1 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23989686&form=6&db=m Anti-Inflammatory Effects of Total Isoflavones from Pueraria lobata on Cerebral Ischemia in Rats. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24342702&form=6&db=m 2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32552356&form=6&db=m Neuroprotective effect of Umbelliferone against Cerebral ischemia/Reperfusion induced neurological deficits: in-vivo and in-silico studies. unassigned -
1.14.99.1 Brain Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33842985&form=6&db=m MiRNA-34c-5p protects against cerebral ischemia/reperfusion injury: involvement of anti-apoptotic and anti-inflammatory activities. unassigned -
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6777069&form=6&db=m Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6798171&form=6&db=m Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury. therapeutic application,unassigned 1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7238914&form=6&db=m Prostaglandins in physiological and in certain pathological responses of the cerebral circulation. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9629843&form=6&db=m Cyclooxygenase-2 is induced globally in infarcted human brain. causal interaction,unassigned 2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9724813&form=6&db=m Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10412795&form=6&db=m Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10566967&form=6&db=m The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059791&form=6&db=m Neuroinflammatory signaling upregulation in Alzheimer's disease. therapeutic application,unassigned 1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158633&form=6&db=m Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179847&form=6&db=m Role of altered cyclooxygenase metabolism in impaired cerebrovasodilation to nociceptin/orphanin FQ following brain injury. ongoing research,unassigned 2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489250&form=6&db=m Vasopressin induced cyclooxygenase dependent superoxide generation contributes to K(+) channel function impairment after brain injury. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11565600&form=6&db=m Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglia/brain macrophages in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11588328&form=6&db=m Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity. causal interaction,unassigned 4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11740205&form=6&db=m Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821016&form=6&db=m The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11852973&form=6&db=m Cyclooxygenase inhibition as a strategy to ameliorate brain injury. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12225656&form=6&db=m Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury. therapeutic application,unassigned 1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12364744&form=6&db=m Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432919&form=6&db=m Prostaglandins and other lipid mediators in Alzheimer's disease. causal interaction,unassigned 3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12766646&form=6&db=m Cyclooxygenase-2-dependent superoxide generation contributes to age-dependent impairment of G protein-mediated cerebrovasodilation. therapeutic application,unassigned 1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15064140&form=6&db=m Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150870&form=6&db=m [The dynamically changes of COX-2 and the gene expression of COX-2 mRNA after traumatic brain injury in rats] causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15581278&form=6&db=m NMDA and age dependent cerebral hemodynamics after traumatic brain injury. unassigned -
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15656909&form=6&db=m Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15771647&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 mRNA in brain damage induced by lipopolysaccharide and intermittent hypoxia-ischemia in neonatal rats. causal interaction,unassigned 3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16259374&form=6&db=m [The expression of COX-1 and COX-2 following brain injuries] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16263251&form=6&db=m Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16294091&form=6&db=m Mercaptoethylguanidine inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expressions induced in rats after fluid-percussion brain injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16518028&form=6&db=m Effects of the selective cyclooxygenase-2 inhibitor rofecoxib on cell death following traumatic brain injury in the rat. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16777358&form=6&db=m COX-2 is associated with cadmium-induced ICAM-1 expression in cerebrovascular endothelial cells. ongoing research,unassigned 4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820798&form=6&db=m Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935468&form=6&db=m BK-induced COX-2 expression via PKC-delta-dependent activation of p42/p44 MAPK and NF-kappaB in astrocytes. therapeutic application,unassigned 1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17127365&form=6&db=m Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. causal interaction,unassigned 2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17176264&form=6&db=m Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17564305&form=6&db=m Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17622965&form=6&db=m Cyclooxygenase-2 activity following traumatic brain injury in the developing rat. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18162486&form=6&db=m Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18293408&form=6&db=m Calcium/calcineurin signaling in primary cortical astrocyte cultures: Rcan1-4 and cyclooxygenase-2 as NFAT target genes. unassigned -
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537663&form=6&db=m Cyclooxygenase inhibition in ischemic brain injury. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19384589&form=6&db=m PGF(2alpha) FP Receptor Contributes to Brain Damage Following Transient Focal Brain Ischemia. causal interaction,unassigned 3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20029340&form=6&db=m Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20137682&form=6&db=m [Brain injury in adenosine A1 receptor knock-out mice after pentetrazole kindling and its correlation with COX-2] diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20166930&form=6&db=m Progress in COX-2 inhibitors: a journey so far. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353773&form=6&db=m The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20386979&form=6&db=m Spatio-Temporal Distribution of Inflammatory Reaction and Expression of TLR2/4 Signaling Pathway in Rat Brain Following Permanent Focal Cerebral Ischemia. causal interaction,unassigned 3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20868723&form=6&db=m Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21725746&form=6&db=m The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21939736&form=6&db=m Function of prostaglandin E2 EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022466&form=6&db=m Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. therapeutic application,unassigned 1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23083210&form=6&db=m Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23624225&form=6&db=m COX2-derived primary and cyclopentenone prostaglandins are increased after asphyxial cardiac arrest. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973859&form=6&db=m Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24084689&form=6&db=m Effects of isoflurane on brain inflammation after subarachnoid hemorrhage in mice. diagnostic usage,unassigned 3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24375716&form=6&db=m Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25080336&form=6&db=m Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25597483&form=6&db=m COX-2 regulation and TUNEL-positive cell death differ between genders in the secondary inflammatory response following experimental penetrating focal brain injury in rats. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25754985&form=6&db=m Protein Disulfide Isomerase as a Novel Target for Cyclopentenone Prostaglandins: Implications for Hypoxic Ischemic Injury. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25893744&form=6&db=m A dual inhibitor of cyclooxygenase and 5-lipoxygenase protects against kainic acid-induced brain injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26232001&form=6&db=m Intracerebral hemorrhage outcomes following selective blockade or stimulation of the PGE2 EP1 receptor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26463949&form=6&db=m Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27087648&form=6&db=m Trans-Cinnamaldehyde, An Essential Oil in Cinnamon Powder, Ameliorates Cerebral Ischemia-Induced Brain Injury via Inhibition of Neuroinflammation Through Attenuation of iNOS, COX-2 Expression and NF?-B Signaling Pathway. therapeutic application,unassigned 4,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27220433&form=6&db=m [Mechanism research and effect of ulinastatin in the brain tissue injury of acute hydrogen sulfide intoxicated rats]. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29792868&form=6&db=m AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats. unassigned -
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31217870&form=6&db=m MiR-21b-3p protects NS2OY cells against oxygen-glucose deprivation/reperfusion-induced injury by down-regulating cyclooxygenase-2. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33094540&form=6&db=m Small molecules targeting cyclooxygenase/prostanoid cascade in experimental brain ischemia: Do they translate? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34067678&form=6&db=m Ergosta-7,9(11),22-trien-3?-ol Alleviates Intracerebral Hemorrhage-Induced Brain Injury and BV-2 Microglial Activation. ongoing research,unassigned 3,0
1.14.99.1 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177398&form=6&db=m Celecoxib Alleviates Radiation-Induced Brain Injury in Rats by Maintaining the Integrity of Blood-Brain Barrier. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19660237&form=6&db=m Effect of COX-2 inhibitor meloxicam against traumatic brain injury-induced biochemical, histopathological changes and blood-brain barrier permeability. ongoing research,unassigned 4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6769796&form=6&db=m Cerebral oedema and blood-brain and blood-CSF barriers in experimental brain trauma: effect of indomethacin-A prostaglandin synthetase inhibitor. therapeutic application,unassigned 1,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10674759&form=6&db=m Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10972245&form=6&db=m Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat. ongoing research,unassigned 2,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11565600&form=6&db=m Traumatic brain injury induces prolonged accumulation of cyclooxygenase-1 expressing microglia/brain macrophages in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11703397&form=6&db=m Activation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12005397&form=6&db=m Persistent accumulation of cyclooxygenase-1-expressing microglial cells and macrophages and transient upregulation by endothelium in human brain injury. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12410334&form=6&db=m Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12482118&form=6&db=m Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150870&form=6&db=m [The dynamically changes of COX-2 and the gene expression of COX-2 mRNA after traumatic brain injury in rats] causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15730585&form=6&db=m Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. causal interaction,unassigned 4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16518028&form=6&db=m Effects of the selective cyclooxygenase-2 inhibitor rofecoxib on cell death following traumatic brain injury in the rat. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17622965&form=6&db=m Cyclooxygenase-2 activity following traumatic brain injury in the developing rat. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18711748&form=6&db=m Genetic disruption of cyclooxygenase-2 does not improve histological or behavioral outcome after traumatic brain injury in mice. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19719848&form=6&db=m Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21063331&form=6&db=m Which is more effective in reducing secondary brain damage resulting from cyclooxygenase expression following traumatic brain injury: calcium channel blockers or cox inhibitors? causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21561314&form=6&db=m The Anti-Inflammatory Drug Carprofen Improves Long-Term Outcome and Induces Gliogenesis after Traumatic Brain Injury. causal interaction,unassigned 3,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21866634&form=6&db=m [The effect of nimesulide on learning and memory function after serve traumatic brain injury in rats]. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22742420&form=6&db=m Curcuminoids in Neurodegenerative Diseases. causal interaction,unassigned 2,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23122881&form=6&db=m Effects of selective and non-selective cyclooxygenase inhibition against neurological deficit and brain oedema following closed head injury in mice. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23268351&form=6&db=m Impact of 5-lipoxygenase inhibitors on the spatiotemporal distribution of inflammatory cells and neuronal COX-2 expression following experimental traumatic brain injury in rats. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23492757&form=6&db=m The effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats. therapeutic application,unassigned 4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25140201&form=6&db=m The effects of cyclooxygenase inhibitors on the gastric emptying and small intestine transit in the male rats following traumatic brain injury. ongoing research,unassigned 3,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206921&form=6&db=m Sequential expression of cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor in rat hippocampal neurons after fluid percussion injury. causal interaction,unassigned 3,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25229663&form=6&db=m Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25387671&form=6&db=m Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25472548&form=6&db=m Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579788&form=6&db=m A single dose of PPAR? agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats. causal interaction,unassigned 1,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26781425&form=6&db=m COX-1 and COX-2 polymorphisms in susceptibility to cerebral palsy in very preterm infants. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31417487&form=6&db=m COX-2 Inhibition by Diclofenac Is Associated With Decreased Apoptosis and Lesion Area After Experimental Focal Penetrating Traumatic Brain Injury in Rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31533781&form=6&db=m miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Brain Injuries, Traumatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1926236&form=6&db=m Effect of indomethacin on edema following single and repetitive cerebral ischemia in the gerbil. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2501915&form=6&db=m Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3090061&form=6&db=m Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis. therapeutic application,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8371169&form=6&db=m Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8717374&form=6&db=m Induction of PGH synthase and c-fos mRNA during early reperfusion of ischemic rat brain. causal interaction,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898713&form=6&db=m Cyclo-oxygenase-2 messenger RNA induction in focal cerebral ischemia. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930343&form=6&db=m Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9092596&form=6&db=m Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9177247&form=6&db=m Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9252233&form=6&db=m Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid. unassigned -
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9629843&form=6&db=m Cyclooxygenase-2 is induced globally in infarcted human brain. causal interaction,unassigned 2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9724813&form=6&db=m Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9832215&form=6&db=m Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10380963&form=6&db=m A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10412795&form=6&db=m Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10507549&form=6&db=m Phenidone attenuates oxygen/glucose deprivation-induced neurotoxicity by antioxidant and antiapoptotic action in mouse cortical cultures. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10528118&form=6&db=m Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10566967&form=6&db=m The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10568519&form=6&db=m Induction of cyclooxygenase-2 in the rat brain after a mild episode of focal ischemia without tissue inflammation or neural cell damage. causal interaction,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10584847&form=6&db=m Induction of cyclooxygenase-2 messenger RNA after transient and permanent middle cerebral artery occlusion in rats: comparison with c-fos messenger RNA by using in situ hybridization. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651024&form=6&db=m Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10773011&form=6&db=m Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture. causal interaction,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884021&form=6&db=m Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury? therapeutic application,unassigned 1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10938410&form=6&db=m Induction of PGHS-2 mRNA in response to cerebral hypoperfusion in late-gestation fetal sheep. unassigned -
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029637&form=6&db=m Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration. causal interaction,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059791&form=6&db=m Neuroinflammatory signaling upregulation in Alzheimer's disease. therapeutic application,unassigned 1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158633&form=6&db=m Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11384620&form=6&db=m Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11588328&form=6&db=m Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity. causal interaction,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11740205&form=6&db=m Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11814419&form=6&db=m Down regulation of COX-2 is involved in hyperbaric oxygen treatment in a rat transient focal cerebral ischemia model. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12398903&form=6&db=m Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12410381&form=6&db=m A comparative study on the expression of cyclooxygenase and 5-lipoxygenase during cerebral ischemia in humans. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12505683&form=6&db=m Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12524144&form=6&db=m Suppression of hyperemia and DNA oxidation by indomethacin in cerebral ischemia. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12535784&form=6&db=m Cyclooxygenase-2 mRNA expression is associated with c-fos mRNA expression and transient water ADC reduction detected with diffusion MRI during acute focal ischemia in rats. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12773326&form=6&db=m Cyclooxygenase 2 and intermittent hypoxia-induced spatial deficits in the rat. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12859668&form=6&db=m Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14512150&form=6&db=m Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715958&form=6&db=m Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15064140&form=6&db=m Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719708&form=6&db=m Rationale for testing the cardiovascular risk for patients with COX-2 inhibitors on the basis of biomarker NT-proBNP. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15737438&form=6&db=m Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756931&form=6&db=m Tenoxicam exerts a neuroprotective action after cerebral ischemia in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15780193&form=6&db=m Down regulation of cyclooxygenase-2 is involved in delayed neuroprotection by ischemic preconditioning in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15936193&form=6&db=m Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia. therapeutic application,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15964567&form=6&db=m The dual role of prostaglandin E(2) in excitotoxicity and preconditioning-induced neuroprotection. causal interaction,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15996566&form=6&db=m S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A(2)-induced apoptosis. causal interaction,unassigned 3,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16253424&form=6&db=m Differential regulation of cyclooxygenase-2 in the rat hippocampus after cerebral ischemia and ischemic tolerance. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16502013&form=6&db=m 1alpha,25-Dihydroxyvitamin D(3) treatment does not alter neuronal cyclooxygenase-2 expression in the cerebral cortex after stroke. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16567054&form=6&db=m Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16770015&form=6&db=m Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820798&form=6&db=m Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049741&form=6&db=m Induced angiogenesis under cerebral ischemia by cyclooxygenase 2 and hypoxia-inducible factor naked DNA in a rat indirect-bypass model. unassigned -
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17194886&form=6&db=m Effects of triflusal and aspirin in a rat model of cerebral ischemia. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17271370&form=6&db=m Melatonin reduced volume of cerebral infarct induced by photothrombosis in wild-type mice, not in Cyclooxygenase-1 gene knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574754&form=6&db=m Divergent effects of prostaglandin receptor signaling on neuronal survival. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17629358&form=6&db=m Roles of prostaglandin synthesis in excitotoxic brain diseases. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17763946&form=6&db=m Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2 alpha exacerbate hypoxic neuronal injury in neuron-enriched primary culture. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18178094&form=6&db=m Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway. causal interaction,unassigned 2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18472336&form=6&db=m Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia. causal interaction,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19073437&form=6&db=m Selective blockade of PGE2 EP1 receptor protects brain against experimental ischemia and excitotoxicity, and hippocampal slice cultures against oxygen-glucose deprivation. causal interaction,unassigned 2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808012&form=6&db=m Emerging roles of PGE(2) receptors in models of neurological disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353773&form=6&db=m The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20673332&form=6&db=m Cytosolic phospholipase A2 alpha amplifies early cyclooxygenase-2 expression, oxidative stress and MAP kinase phosphorylation after cerebral ischemia in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21164135&form=6&db=m Cyclooxygenase-2 mediates hyperbaric oxygen preconditioning in the rat model of transient global cerebral ischemia. ongoing research,unassigned 2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21850441&form=6&db=m Aged Garlic Extract Attenuates Cerebral Damage and Cyclooxygenase-2 Induction after Ischemia and Reperfusion in Rats. ongoing research,unassigned 4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21939736&form=6&db=m Function of prostaglandin E2 EP receptors in the acute outcome of rodent hypoxic ischemic encephalopathy. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21995864&form=6&db=m Effect of nonselective and selective COX-2 inhibitors on memory dysfunction, glutathione system, and tumor necrosis factor alpha level against cerebral ischemia reperfusion injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796597&form=6&db=m Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosis. therapeutic application,unassigned 1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23075731&form=6&db=m Flurbiprofen axetil promotes neuroprotection by activation of cerebral peroxisome proliferator-activated receptor gamma after focal cerebral ischemia in rats. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23609497&form=6&db=m Apobec-1 increases cyclooxygenase-2 and aggravates injury in oxygen-deprived neurogenic cells and middle cerebral artery occlusion rats. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23762140&form=6&db=m Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function. causal interaction,unassigned 3,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23995802&form=6&db=m The role of prostaglandin e2 in stroke-reperfusion injury. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25229174&form=6&db=m Reversible cerebral vasoconstriction syndrome possibly induced by etoricoxib. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27133043&form=6&db=m Study on cerebroprotective actions of Clerodendron glandulosumleaves extract against long term bilateral common carotid artery occlusion in rats. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28769765&form=6&db=m Mesenchymal Stem Cell-Derived Extracellular Vesicles Ameliorates Hippocampal Synaptic Impairment after Transient Global Ischemia. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30936996&form=6&db=m Resveratrol downregulates the TLR4 signaling pathway to reduce brain damage in a rat model of focal cerebral ischemia. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973660&form=6&db=m Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33053444&form=6&db=m Prostaglandin E receptors as targets for ischemic stroke: Novel evidence and molecular mechanisms of efficacy. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Brain Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34324865&form=6&db=m LncRNA-Malat1 down-regulates miR-211-5p expression to promote neuronal damage from cerebral ischemia reperfusion injury. causal interaction,unassigned 4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987308&form=6&db=m Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11710598&form=6&db=m Paradoxical effect of aspirin on the growth of C6 rat glioma and on time of development of ENU-induced tumors of the nervous system. causal interaction,unassigned 3,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11772429&form=6&db=m A cyclooxygenase-2 (COX-2) inhibitor compared with dexamethasone in a survival study of rats with intracerebral 9L gliosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11911965&form=6&db=m Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxib. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576462&form=6&db=m Microglia cyclooxygenase-2 activity in experimental gliomas: possible role in cerebral edema formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631609&form=6&db=m Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795056&form=6&db=m Potential for combined modality therapy of cyclooxygenase inhibitors and radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902860&form=6&db=m COX-2 inhibitor as a radiation enhancer: new strategies for the treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14519750&form=6&db=m Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: a rational advance? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693827&form=6&db=m The eicosanoid cascade: possible role in gliomas and meningiomas. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15015658&form=6&db=m Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15118886&form=6&db=m Inhibition of the arachidonic acid metabolism blocks endothelial cell migration and induces apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15249715&form=6&db=m Brain edema in neurooncology: radiological assessment and management. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15460407&form=6&db=m [Expression and clinical significance of cyclooxygenase-2 in medulloblastoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719279&form=6&db=m Phase I/II study of selective cyclooxygenase-2 inhibitor celecoxib as a radiation sensitizer in patients with unresectable brain metastases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080553&form=6&db=m Cyclooxygenase-2 expression in brain metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16223182&form=6&db=m [A case report of chemotherapy with thalidomide, celecoxib and gemcitabine in the treatment of patients with brain metastases from lung cancer] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16258258&form=6&db=m Avoiding glucocorticoid administration in a neurooncological case. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900783&form=6&db=m Cyclooxygenase-2 (COX-2) overexpression in childhood brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369862&form=6&db=m Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581403&form=6&db=m Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18715952&form=6&db=m Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,3
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19707506&form=6&db=m Cytoplasmic Expression of HuR is Related to Cyclooxygenase-2 Expression in Colon Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21862232&form=6&db=m Augmentation of chemotherapy-triggered glioma cell apoptosis by blockade of arachidonic acid metabolism-the potential role of ceramide accumulation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22213142&form=6&db=m Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23250387&form=6&db=m Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24243648&form=6&db=m Intratumoral COX-2 inhibition enhances GM-CSF immunotherapy against established mouse GL261 brain tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24614081&form=6&db=m COX-2 drives metastatic breast cells from brain lesions into the cerebrospinal fluid and systemic circulation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25022336&form=6&db=m Immunizations with unmodified tumor cells and simultaneous COX-2 inhibition eradicate malignant rat brain tumors and induce a long-lasting CD8(+) T cell memory. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30761522&form=6&db=m Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Brain Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34086522&form=6&db=m Plasma circulating cell free messenger RNA as a potential biomarker of melanoma. diagnostic usage,unassigned 3,0
1.14.99.1 Breast Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14659355&form=6&db=m Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Breast Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16502408&form=6&db=m Nonsteroidal antiinflammatory drugs, cyclooxygenase polymorphisms, and the risk of developing breast carcinoma among women with benign breast disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Breast Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952860&form=6&db=m Glucocorticoid receptor changes its cellular location with breast cancer development. causal interaction,unassigned 3,0
1.14.99.1 Breast Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236511&form=6&db=m Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Breast Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24669166&form=6&db=m Role of Cyclooxygenase 2 (COX-2) in Prognosis of Breast Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=121602&form=6&db=m Prostaglandin synthetase and prostaglandin E2 levels in human breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=526539&form=6&db=m Prostaglandins in human breast cancer. Identification of a cytosolic prostaglandin-9-keto-reductase activity. unassigned -
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=870901&form=6&db=m Calcium metabolism in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1005735&form=6&db=m Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1306527&form=6&db=m Effects of high and low dietary fat and indomethacin on tumour growth, hormone receptor status and growth factor expression in DMBA-induced rat breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1917383&form=6&db=m Thromboxane production by platelets during tumor cell-induced platelet activation. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2126634&form=6&db=m In vitro capacity of various cyclooxygenase inhibitors to revert immune suppression caused by radiation therapy for breast cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2513994&form=6&db=m Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3335042&form=6&db=m Anticarcinogenic activity of quinacrine in the rat mammary gland. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6277959&form=6&db=m Prostaglandin E2 and cyclic AMP in tumor and plasma of breast cancer patients. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6768115&form=6&db=m The direct inhibition of prostaglandin synthetase of human breast cancer tumor tissue by tamoxifen. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7129717&form=6&db=m Relationship of the suppression of macrophage mediated tumor cytotoxicity in conjunction with secretion of prostaglandin from the macrophages of breast cancer patients. ongoing research,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7854776&form=6&db=m Effects of eicosanoid synthesis inhibitors on the in vitro growth and prostaglandin E and leukotriene B secretion of a human breast cancer cell line. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8750525&form=6&db=m In vitro effects of eicosanoid synthesis inhibitors in the presence of linoleic acid on MDA-MB-231 human breast cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8771566&form=6&db=m Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8912844&form=6&db=m Differential expression and regulation of cyclooxygenase-1 and -2 in two human breast cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9066651&form=6&db=m Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. ongoing research,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9383784&form=6&db=m Effects of dietary menhaden oil, soy, and a cyclooxygenase inhibitor on human breast cancer cell growth and metastasis in nude mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9478277&form=6&db=m Dietary fat and breast cancer metastasis by human tumor xenografts. therapeutic application,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9521170&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9785386&form=6&db=m Effect of hormonal status on the expression of the cyclooxygenase 1 and 2 genes and prostaglandin synthesis in rat mammary glands. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10399316&form=6&db=m Cyclooxygenase-1 and -2 isoenzymes. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402236&form=6&db=m The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10403538&form=6&db=m Correlation of aromatase and cyclooxygenase gene expression in human breast cancer specimens. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10465664&form=6&db=m Genetic induction and upregulation of cyclooxygenase (COX) and aromatase (CYP19): an extension of the dietary fat hypothesis of breast cancer. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571077&form=6&db=m Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or -2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10626809&form=6&db=m Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10786667&form=6&db=m Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135226&form=6&db=m COX-2 is expressed in human pulmonary, colonic, and mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11397667&form=6&db=m Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401676&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in skin cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477578&form=6&db=m Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11501838&form=6&db=m Cyclooxygenase-2, P-glycoprotein-170 and drug resistance; is chemoprevention against multidrug resistance possible? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595712&form=6&db=m Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11705852&form=6&db=m Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830510&form=6&db=m Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11848504&form=6&db=m Dose-response effects of the COX-2 inhibitor, celecoxib, on the chemoprevention of mammary carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11848612&form=6&db=m HER-2/neu-Positive breast carcinoma: molecular concomitants by proteomic analysis and their therapeutic implications. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11850206&form=6&db=m Aromatase and COX-2 expression in human breast cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11850210&form=6&db=m Molecular pharmacology of aromatase and its regulation by endogenous and exogenous agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11897504&form=6&db=m Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11901151&form=6&db=m Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912139&form=6&db=m Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956094&form=6&db=m Selective cyclooxygenase (COX)-1 or COX-2 inhibitors control metastatic disease in a murine model of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011987&form=6&db=m Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma (Review). causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12037025&form=6&db=m Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063562&form=6&db=m Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075734&form=6&db=m Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086401&form=6&db=m COX-2 and prostanoid receptors: good targets for chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12201625&form=6&db=m The mRNA expression of cyclo-oxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12208745&form=6&db=m Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12359744&form=6&db=m Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12383132&form=6&db=m Current concepts in cyclooxygenase inhibition in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12408376&form=6&db=m Cyclooxygenase inhibitors block cell growth, increase ceramide and inhibit cell cycle. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12431470&form=6&db=m The role of cyclooxygenase-2 (COX-2) in breast cancer, and implications of COX-2 inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12455057&form=6&db=m Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468543&form=6&db=m Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12472107&form=6&db=m Role of cyclooxygenase-2 in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12487506&form=6&db=m Advances in breast oncology: the 2002 ASCO meeting. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12592372&form=6&db=m Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12636206&form=6&db=m In vitro growth inhibition by indomethacin on human oral squamous cell carcinoma lines synergistically suppressed by all-trans retinoic acid correlating to apoptosis. causal interaction,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12667327&form=6&db=m [Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12736714&form=6&db=m Inhibition of cyclooxygenase-2 and activation of peroxisome proliferator-activated receptor-gamma synergistically induces apoptosis and inhibits growth of human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12740157&form=6&db=m Cyclo-oxygenase-2 (COX-2) mRNA expression correlates with progesterone receptor positivity in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12784332&form=6&db=m Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12825860&form=6&db=m Phosphocitrate inhibits calcium hydroxyapatite induced mitogenesis and upregulation of matrix metalloproteinase-1, interleukin-1beta and cyclooxygenase-2 mRNA in human breast cancer cell lines. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12855643&form=6&db=m Correlation between cyclooxygenase-2 expression and angiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883688&form=6&db=m Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12884024&form=6&db=m Analysis of cyclooxygenase-2 expression in human breast cancer: high throughput tissue microarray analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12887516&form=6&db=m COX-2 inhibitors and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895350&form=6&db=m [Expression of the cyclooxygenase-2 gene in human breast carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902864&form=6&db=m Effect of the combination of docetaxel, zoledronic acid, and a COX-2 inhibitor on the growth of human breast cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907138&form=6&db=m Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926055&form=6&db=m Expression of cyclooxygenase-2 in malignant and benign breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499627&form=6&db=m Role of prostaglandin E2 receptors in migration of murine and human breast cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587862&form=6&db=m COX-2 inhibitors for the prevention of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587863&form=6&db=m Novel agents for the prevention of breast cancer: targeting transcription factors and signal transduction pathways. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594936&form=6&db=m Chemoprevention of cancer--focusing on clinical trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14602487&form=6&db=m Lack of prognostic effect of Cox-2 expression in primary breast cancer on short-term follow-up. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605950&form=6&db=m Expression of cyclooxygenase-1 and -2 in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623055&form=6&db=m The effect of deletion of cyclooxygenase-2, prostaglandin receptor EP2, or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623548&form=6&db=m Breast cancer prevention--clinical trials strategies involving aromatase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623549&form=6&db=m Cyclooxygenase-2 and chemoprevention of breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623550&form=6&db=m Aromatase and cyclooxygenases: enzymes in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14642098&form=6&db=m [The clinical significance of expression of cyclooxygenase-2 gene in breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14648704&form=6&db=m PGE2-mediated upregulation of iNOS in murine breast cancer cells through the activation of EP4 receptors. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14659355&form=6&db=m Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681319&form=6&db=m Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688410&form=6&db=m Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693742&form=6&db=m The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717665&form=6&db=m Cyclooxygenase-2 expression: a potential prognostic and predictive marker for high-grade ductal carcinoma in situ of the breast. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14735188&form=6&db=m COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767524&form=6&db=m Combining flavopiridol with various signal transduction inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871855&form=6&db=m Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14973114&form=6&db=m Cyclooxygenase-2 is essential for HER2/neu to suppress N- (4-hydroxyphenyl)retinamide apoptotic effects in breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14993030&form=6&db=m Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15000150&form=6&db=m Role of cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15001242&form=6&db=m Cyclooxygenase-2 expression correlates with diminished survival in invasive breast cancer treated with mastectomy and radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020235&form=6&db=m Growth inhibition of breast epithelial cells by celecoxib is associated with upregulation of insulin-like growth factor binding protein-3 expression. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15023244&form=6&db=m Prognostic impact of cyclooxygenase-2 in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15033780&form=6&db=m CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15036660&form=6&db=m MCF-7 breast cancer cell line grown in agarose culture for study of COX-2 inhibitors in three-dimensional growth system. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15050918&form=6&db=m Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. therapeutic application,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15052544&form=6&db=m Cyclooxygenase-2: a potential target in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179621&form=6&db=m The role of COX-2 inhibition in breast cancer treatment and prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15213717&form=6&db=m Antimetastatic activity of a cyclooxygenase-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217498&form=6&db=m Promoter methylation regulates cyclooxygenase expression in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217939&form=6&db=m Phase II study of celecoxib and trastuzumab in metastatic breast cancer patients who have progressed after prior trastuzumab-based treatments. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15228443&form=6&db=m Cyclooxygenase 2 (COX2) expression is associated with poor outcome in ER-negative, but not ER-positive, breast cancer. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239337&form=6&db=m [Cyclooxygenase 2 and breast cancer. From biological concepts to therapeutic trials] causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15290792&form=6&db=m Invasive and angiogenic phenotype of MCF-7 human breast tumor cells expressing human cyclooxygenase-2. ongoing research,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15328200&form=6&db=m Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15330183&form=6&db=m Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332534&form=6&db=m [COX and study of cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15377836&form=6&db=m Vitamin E analog alpha-TEA and celecoxib alone and together reduce human MDA-MB-435-FL-GFP breast cancer burden and metastasis in nude mice. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499599&form=6&db=m Elevated expression of cyclooxygenase-2 in breast cancer and ductal carcinoma in situ has no correlation with established prognostic markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15533902&form=6&db=m Lack of effect of celecoxib on prostaglandin E2 concentrations in nipple aspirate fluid from women at increased risk of breast cancer. unassigned -
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15550858&form=6&db=m Novel sensitizing agents: potential contribution of COX-2 inhibitor for endocrine therapy of breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15554390&form=6&db=m Control of pulmonary metastases of rat mammary cancer by inhibition of uPA and COX-2, singly and in combination. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15561779&form=6&db=m Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15570054&form=6&db=m Vitamin E and breast cancer. therapeutic application,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585631&form=6&db=m Increased angiogenesis and lymphangiogenesis in inflammatory versus noninflammatory breast cancer by real-time reverse transcriptase-PCR gene expression quantification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15589595&form=6&db=m COX-2, c-KIT and HER-2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623590&form=6&db=m Down-regulation of intratumoral aromatase messenger RNA levels by docetaxel in human breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15642177&form=6&db=m Do early premalignant changes in normal breast epithelial cells predict cancer development? causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15687328&form=6&db=m Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15741054&form=6&db=m Comparison of stearidonic acid and alpha-linolenic acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures. ongoing research,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753376&form=6&db=m p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754118&form=6&db=m Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809733&form=6&db=m COX-2 overexpression increases motility and invasion of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15833882&form=6&db=m The retinoid X receptor-selective retinoid, LGD1069, down-regulates cyclooxygenase-2 expression in human breast cells through transcription factor crosstalk: implications for molecular-based chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15842638&form=6&db=m COX-2 expression in DCIS: correlation with VEGF, HER-2/neu, prognostic molecular markers and clinicopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856465&form=6&db=m Cyclooxygenase-2 overexpression in MCF-10F human breast epithelial cells inhibits proliferation, apoptosis and differentiation, and causes partial transformation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878334&form=6&db=m Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899633&form=6&db=m [Cyclooxygenase 2 and breast cancer. From biological concepts to clinical trials] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899809&form=6&db=m Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930264&form=6&db=m The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15964185&form=6&db=m Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15967164&form=6&db=m COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987447&form=6&db=m Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16030101&form=6&db=m Loss of FHIT expression in breast cancer is correlated with poor prognostic markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081048&form=6&db=m Evaluation of potential Stat3-regulated genes in human breast cancer. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16100520&form=6&db=m Potential use of COX-2-aromatase inhibitor combinations in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127422&form=6&db=m Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16131446&form=6&db=m Localisation of COX-2 protein is different in breast ductal carcinoma and adjacent non-tumour ductal epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16168133&form=6&db=m Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16194365&form=6&db=m [The effect of selective cyclooxygenase-2 inhibitor nimesulide on breast cancer induced by dimethylbenzoic acid in rats] causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213894&form=6&db=m Synergistic tumoricidal effect between celecoxib and adenoviral-mediated delivery of mda-7 in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243823&form=6&db=m Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16287071&form=6&db=m Quantitative analysis of aromatase mRNA expression derived from various promoters (I.4, I.3, PII and I.7) and its association with expression of TNF-alpha, IL-6 and COX-2 mRNAs in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309227&form=6&db=m Cox-2 levels in canine mammary tumors, including inflammatory mammary carcinoma: clinicopathological features and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322898&form=6&db=m Correlation of cyclooxygenase-2 and aromatase immunohistochemical expression in invasive ductal carcinoma, ductal carcinoma in situ, and adjacent normal epithelium. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16343343&form=6&db=m Association between frequent use of nonsteroidal anti-inflammatory drugs and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16353170&form=6&db=m Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16365029&form=6&db=m Cyclooxygenase 2 polymorphism (Val511Ala), nonsteroidal anti-inflammatory drug use and breast cancer in African American women. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16374068&form=6&db=m Overexpression of cyclooxygenase-2 is associated with a favorable prognostic phenotype in breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391819&form=6&db=m COX-2 induction by heparanase in the progression of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16421596&form=6&db=m Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424122&form=6&db=m Conjugated Linoleic Acid Attenuates Cyclooxygenase-2 Transcriptional Activity via an Anti-AP-1 Mechanism in MCF-7 Breast Cancer Cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16445867&form=6&db=m Reduction in the risk of human breast cancer by selective cyclooxygenase-2 (COX-2) inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16457694&form=6&db=m Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16457848&form=6&db=m COX-2 induces IL-11 production in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16480277&form=6&db=m Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489006&form=6&db=m Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489098&form=6&db=m The Cyclooxygenase-2 (PTGS2) 8473T>C Polymorphism is Associated with Breast Cancer Risk. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16497869&form=6&db=m Overexpression of cyclo-oxygenase-2 is an independent predictor of unfavourable outcome in node-negative breast cancer, but is not associated with protein kinase B (Akt) and mitogen-activated protein kinase (ERK1/2, p38) activation or with Her-2/neu signalling pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16498361&form=6&db=m Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16502408&form=6&db=m Nonsteroidal antiinflammatory drugs, cyclooxygenase polymorphisms, and the risk of developing breast carcinoma among women with benign breast disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505480&form=6&db=m NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507389&form=6&db=m Aberrant methylation of cyclooxygenase-2 in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507393&form=6&db=m Current directions for COX-2 inhibition in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507397&form=6&db=m Study of COX-2, Ki67, and p53 expression to predict effectiveness of 5-flurouracil, epirubicin and cyclophosphamide with celecoxib treatment in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16531064&form=6&db=m Cyclooxygenase-2 as a target for anticancer drug development. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16540639&form=6&db=m Prostaglandin E Receptor EP4 Antagonism Inhibits Breast Cancer Metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16556483&form=6&db=m Quantitative analysis of aromatase, sulfatase and 17beta-HSD(1) mRNA expression in soft tissue metastases of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16570043&form=6&db=m COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16650963&form=6&db=m Cyclo-oxygenase-2 (COX-2) mRNA expression and hormone receptor status in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16669452&form=6&db=m Elevated cyclooxygenase-2 expression is associated with histological grade in invasive ductal breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16678856&form=6&db=m Involvement of IL-8 in COX-2-mediated bone metastases from breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16688727&form=6&db=m Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16700663&form=6&db=m Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712450&form=6&db=m Interrelationships between cyclooxygenases and aromatase: unraveling the relevance of cyclooxygenase inhibitors in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797158&form=6&db=m Cox-2 expression on tissue microarray of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806797&form=6&db=m Increases in circulating VEGF levels during COX-2 inhibitor treatment in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820896&form=6&db=m Expression of COX-2 and steroid converting enzymes in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16831226&form=6&db=m Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16870006&form=6&db=m Soya isoflavones suppress phorbol 12-myristate 13-acetate-induced COX-2 expression in MCF-7 cells. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16885386&form=6&db=m 15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16888001&form=6&db=m Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16928824&form=6&db=m Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16952320&form=6&db=m IL-1 does not reverse the anti-proliferative effect of aspirin in breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16964399&form=6&db=m Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966442&form=6&db=m Cyclooxygenase-2 expression in normal and neoplastic canine mammary cell lines. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16967149&form=6&db=m [Cox-2 and CD105 expression in breast cancer and disease-free survival.] diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16997132&form=6&db=m Cyclooxygenase-2 directly regulates gene expression of P450 Cyp19 aromatase promoter regions pII, pI.3 and pI.7 and estradiol production in human breast tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17027257&form=6&db=m A feasibility study of the efficacy and tolerability of the combination of Exemestane with the COX-2 inhibitor Celecoxib in post-menopausal patients with advanced breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049843&form=6&db=m Role of the progesterone receptor (PR) in the regulation of inflammatory response pathways and aromatase in the breast. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17052999&form=6&db=m Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062693&form=6&db=m Effect of simultaneous inhibition of epidermal growth factor receptor and cyclooxygenase-2 in HER-2/neu-positive breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17094899&form=6&db=m [Chemopreventive effect of tamoxifen combined with celecoxib on DMBA-induced breast cancer in rats] causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17096325&form=6&db=m Inflammation and IGF-I activate the Akt pathway in breast cancer. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17097285&form=6&db=m Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-kappaB-mediated increase of intracellular doxorubicin accumulation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17121709&form=6&db=m [Chemopreventive effect of celecoxib against DMBA-induced breast cancer and its mechanism] diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17126249&form=6&db=m The status of cyclooxygenase-2 expression in ductal carcinoma in situ lesions and invasive breast cancer correlates to cyclooxygenase-2 expression in normal breast tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17147116&form=6&db=m [Flow cytometric quantitative analysis of multiple tumor suppressor gene 1 (MTS1) and cyclooxygenase-2 (COX-2) gene expressions in invasive breast cancers and their clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17156488&form=6&db=m A novel role for cyclooxygenase-2 in regulating vascular channel formation by human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17166374&form=6&db=m [Inhibitory effects of Aspisol on growth of transplanted breast cancer in C3H mice] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17181859&form=6&db=m Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17192687&form=6&db=m Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201140&form=6&db=m COX-2 inhibitor celecoxib suppresses tumor growth and lung metastasis of a murine mammary cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17213821&form=6&db=m COX-2 involvement in breast cancer metastasis to bone. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214885&form=6&db=m A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17285134&form=6&db=m Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17315855&form=6&db=m Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17329684&form=6&db=m MR monitoring of cyclooxygenase-2 inhibition of angiogenesis in a human breast cancer model in rats. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332916&form=6&db=m Cyclooxygenase-2 uses the protein kinase C/ interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17352244&form=6&db=m Prognostic factors in Hungarian breast cancer patients. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17364553&form=6&db=m Quantitative analysis of breast cancer tissue microarrays shows high cox-2 expression is associated with poor outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17391824&form=6&db=m Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404058&form=6&db=m Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17418864&form=6&db=m Cyclooxygenase-2 expression induces genomic instability in MCF10A breast epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429393&form=6&db=m Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437270&form=6&db=m Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum. ongoing research,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17465194&form=6&db=m Cyclooxygenase-2 directly induces MCF-7 breast tumor cells to develop into exponentially growing, highly angiogenic and regionally invasive human ductal carcinoma xenografts. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17479405&form=6&db=m Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17510310&form=6&db=m Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17542993&form=6&db=m COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17580278&form=6&db=m Markers of the uPA system and common prognostic factors in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612052&form=6&db=m Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624587&form=6&db=m The role of cyclooxygenase-2 in breast cancer: review. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640394&form=6&db=m Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17657731&form=6&db=m Cyclooxygenase-2 mRNA expression correlates with aromatase expression in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17721268&form=6&db=m COX-2 expression in invasive breast cancer: correlation with prognostic parameters and outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17767925&form=6&db=m Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-kappaB activation and COX-2 expression in human breast epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17851687&form=6&db=m COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17912247&form=6&db=m Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952860&form=6&db=m Glucocorticoid receptor changes its cellular location with breast cancer development. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971769&form=6&db=m COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18001219&form=6&db=m Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006811&form=6&db=m Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045633&form=6&db=m Suppression of aromatase in human breast cells by a cyclooxygenase-2 inhibitor and its analog involves multiple mechanisms independent of cyclooxygenase-2 inhibition. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045954&form=6&db=m Cyclooxygenase-2 inhibitors prevent the development of chemoresistance phenotype in a breast cancer cell line by inhibiting glycoprotein p-170 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18069633&form=6&db=m [Relationship between serum VEGF level and VEGF, COX-2 and MVD expression in breast cancer tissues] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071704&form=6&db=m Impact of celecoxib on capecitabine tolerability and activity in pretreated metastatic breast cancer: results of a phase II study with biomarker evaluation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18087590&form=6&db=m Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18190720&form=6&db=m Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18192694&form=6&db=m 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194278&form=6&db=m NSAIDs and breast cancer: a possible prevention and treatment strategy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199541&form=6&db=m Cyclooxygenase-2 expression during immortalization and breast cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202791&form=6&db=m Differential effects of selective cyclooxygenase-2 inhibitors in inhibiting proliferation and induction of apoptosis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18237249&form=6&db=m Neoadjuvant Therapy with Celecoxib to Women with Early Stage Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18262731&form=6&db=m Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18279516&form=6&db=m Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18319253&form=6&db=m Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18334709&form=6&db=m Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18353210&form=6&db=m [The relationship between lymphatic metastasis and serum vascular endothelial growth factor C and cyclooxygenase 2 expression in breast cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18386173&form=6&db=m Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18447943&form=6&db=m Nonsteroidal anti-inflammatory drugs and breast cancer risk in the National Institutes of Health-AARP Diet and Health Study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18469157&form=6&db=m Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18483177&form=6&db=m Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18498876&form=6&db=m Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18509974&form=6&db=m [The effect of cyclooxygenase-2 on lymphangiogenesis in breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18514508&form=6&db=m Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566569&form=6&db=m Genes controlling spread of breast cancer to lung "gang of 4". causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18612134&form=6&db=m Reduced expression of cyclooxygenase-2 in primary breast cancer. diagnostic usage,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18663571&form=6&db=m Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676768&form=6&db=m Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18791180&form=6&db=m Presenilin 1/gamma-secretase is associated with cadmium-induced E-cadherin cleavage and COX-2 gene expression in T47D breast cancer cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18795070&form=6&db=m Tpl-2/cot and cox-2 in breast cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18819034&form=6&db=m Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18927599&form=6&db=m Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18953425&form=6&db=m The malignant phenotype of breast cancer cells is reduced by COX-2 silencing. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19000652&form=6&db=m Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19020973&form=6&db=m Celecoxib and exemestane versus placebo and exemestane in postmenopausal metastatic breast cancer patients: a double-blind phase III GINECO study. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19046800&form=6&db=m Nimesulide inhibits IFN-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells by COX-2 and PGE2 independent mechanisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056653&form=6&db=m Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19112426&form=6&db=m Aspisol inhibits tumor growth and induces apoptosis in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138835&form=6&db=m A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138958&form=6&db=m Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19176489&form=6&db=m Molecular Characterization of Feline COX-2 and Expression in Feline Mammary Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19188749&form=6&db=m COX-2 expression does not correlate with microvessel density in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19190350&form=6&db=m 17Beta-hydroxysteroid dehydrogenase type 12 in human breast carcinoma: a prognostic factor via potential regulation of fatty acid synthesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218449&form=6&db=m Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19241157&form=6&db=m Decreased TGFbeta signaling and increased COX2 expression in high risk women with increased mammographic breast density. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19244345&form=6&db=m Caveolin-1-mediated suppression of cyclooxygenase-2 via a {beta}-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19254941&form=6&db=m Role of combination therapy with aromatase and cyclooxygenase-2 inhibitors in patients with metastatic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19276290&form=6&db=m Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19282568&form=6&db=m Survival effects of cyclooxygenase-2 and 12-lipooxygenase in Egyptian women with operable breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19293639&form=6&db=m AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19340516&form=6&db=m Neoplasms escape selective COX-2 inhibition in an animal model of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19345476&form=6&db=m Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428334&form=6&db=m A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms. therapeutic application,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428940&form=6&db=m Modulation of Delta9-tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxygenase and aromatase. ongoing research,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19435207&form=6&db=m [The effects of celecoxib on mammary tumorigenesis and aging in HER2/neu transgenic mice] causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19576865&form=6&db=m Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling. ongoing research,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19667157&form=6&db=m Prostaglandin metabolizing enzymes in correlation with vitamin D receptor in benign and malignant breast cell lines. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19715751&form=6&db=m Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723084&form=6&db=m Anti-inflammatory and anticarcinogenic effect of genistein alone or in combination with capsaicin in TPA-treated rat mammary glands or mammary cancer cell line. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759193&form=6&db=m Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer. unassigned -
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19815237&form=6&db=m American Ginseng Inhibits Induced COX-2 and NFKB Activation in Breast Cancer Cells. therapeutic application,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19854050&form=6&db=m Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895368&form=6&db=m Modulation of tumorigenesis and oestrogen receptor-alpha expression by cell culture conditions in a stem cell-derived breast epithelial cell line. ongoing research,unassigned 2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19933077&form=6&db=m Reduced risk of bone metastasis for patients with breast cancer who use COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19940361&form=6&db=m Cyclo-oxygenase 2 modulates chemoresistance in breast cancer cells involving NF-kappaB. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19954924&form=6&db=m Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956498&form=6&db=m Expression of Cyclooxygenase-2 in Human Breast Cancer: Relationship with HER-2/neu and other Clinicopathological Prognostic Factors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19965896&form=6&db=m PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20033767&form=6&db=m Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20033868&form=6&db=m The Licorice Flavonoid Isoliquiritigenin Suppresses Phorbol Ester-induced Cyclooxygenase-2 Expression in the Non-tumorigenic MCF-10A Breast Cell Line. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093341&form=6&db=m Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103725&form=6&db=m Cyclooxygenase-2 inhibition for the prophylaxis and treatment of preinvasive breast cancer in a her-2/neu mouse model. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20193065&form=6&db=m Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20211985&form=6&db=m Cytosolic phospholipase A2 activation correlates with HER2 overexpression and mediates estrogen-dependent breast cancer cell growth. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20229271&form=6&db=m Preventing chemoresistance of human breast cancer cell line, MCF-7 with celecoxib. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236511&form=6&db=m Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20338651&form=6&db=m Prognostic significance of IGF-1R expression in patients treated with breast-conserving surgery and radiation therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20354817&form=6&db=m The value of COX-2 expression in the prognostic parameters of invasive ductal carcinoma of the breast. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20396544&form=6&db=m Clinical value of cyclooxygenase-2 expression in human breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20422426&form=6&db=m Potential role of cyclooxygenase-2 on the regulation of the drug efflux transporter ABCG2 in breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20462604&form=6&db=m Role of COX-2 in Tumorospheres Derived from a Breast Cancer Cell Line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20503412&form=6&db=m Differential regulation of the aggressive phenotype of inflammatory breast cancer cells by prostanoid receptors EP3 and EP4. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20536410&form=6&db=m COX-2 expression in human breast carcinomas: correlation with clinicopathological features and prognostic molecular markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20542113&form=6&db=m COX-2 inhibitor nimesulide analogs are aromatase suppressors in breast cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592360&form=6&db=m Prostaglandin metabolising enzymes and PGE2 are inversely correlated with vitamin D receptor and 25(OH)2D3 in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20596620&form=6&db=m Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20608938&form=6&db=m Relationship between cyclooxygenase-2 and human epidermal growth factor receptor 2 in vascular endothelial growth factor C up-regulation and lymphangiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631072&form=6&db=m Suppression of integrin alpha3beta1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631257&form=6&db=m Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20675158&form=6&db=m COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20676755&form=6&db=m Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20678559&form=6&db=m The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20691996&form=6&db=m Overexpression of COX-2 in celecoxib-resistant breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20697803&form=6&db=m Pre-surgical study of the biological effects of the selective cyclo-oxygenase-2 inhibitor celecoxib in patients with primary breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20711808&form=6&db=m Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20724158&form=6&db=m Selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer risk. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20729081&form=6&db=m Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20819530&form=6&db=m Stable transfection of estrogen receptor-alpha suppresses expression of cyclooxygenase-2 and vascular endothelial growth factor-C in MDA-MB-231 breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20826149&form=6&db=m Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20858737&form=6&db=m Prostaglandin E Receptor EP1 Suppresses Breast Cancer Metastasis and Is Linked to Survival Differences and Cancer Disparities. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876365&form=6&db=m Cyclooxygenase-2 Expression in Animal Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878073&form=6&db=m Down-regulation of CacyBP is associated with poor prognosis and the effects on COX-2 expression in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21044318&form=6&db=m Increasing CD44+/CD24- tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21047437&form=6&db=m Epigenetic change in E-Cardherin and COX-2 to predict chronic periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21059239&form=6&db=m Polymorphisms in regulatory regions of cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069452&form=6&db=m Nuclear co-localization and functional interaction of COX-2 and HIF-1? characterize bone metastasis of human breast carcinoma. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21071999&form=6&db=m Pifithrin-?, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21078168&form=6&db=m COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21085606&form=6&db=m Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140284&form=6&db=m Antiproliferative effects of COX-2 inhibitor celecoxib on human breast cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21153458&form=6&db=m Methylation status and overexpression of COX-2 in Tunisian patients with ductal invasive breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21180996&form=6&db=m Cox-2 and its association with prognostic factors and response to primary chemotherapy in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21225228&form=6&db=m Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21310944&form=6&db=m Macrophages induce COX-2 expression in breast cancer cells: Role of IL-1{beta} auto-amplification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21355070&form=6&db=m Serial changes in the expression of breast cancer-related proteins in response to neoadjuvant chemotherapy. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21371829&form=6&db=m Immunohistochemical COX-2 overexpression correlates with HER-2/neu overexpression in invasive breast carcinomas: A pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21409596&form=6&db=m Identification of Hydroxysteroid (17?) dehydrogenase type 12 (HSD17B12) as a CD8(+) T-cell-defined human tumor antigen of human carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21458568&form=6&db=m In vitro and in vivo effects of a cyclooxygenase-2 inhibitor nimesulide analog JCC76 in aromatase inhibitors-insensitive breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476934&form=6&db=m Prognostic Significance of Cyclooxygenase-2 and Response to Chemotherapy in Invasive Ductal Breast Carcinoma Patients by Real Time Surface Plasmon Resonance Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21533404&form=6&db=m Cyclooxygenase-2 gene expression in human breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21544343&form=6&db=m Effects of linoleic acid and eicosanoid synthesis inhibitors on the growth and c-myc oncogene expression of human breast cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21551001&form=6&db=m The potential role of cyclooxygenase-2 (COX-2) during early breast cancer therapy. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556247&form=6&db=m Effects of celecoxib and ly117018 combination on human breast cancer cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21623034&form=6&db=m Study on cow ghee versus soybean oil on 7,12-dimethylbenz(a)-anthracene induced mammary carcinogenesis & expression of cyclooxygenase-2 & peroxisome proliferators activated receptor-? in rats. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21638077&form=6&db=m Impairment of breast cancer cell invasion by COX-2-specific inhibitor NS398: roles of CXCR4 and of uPA system. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21654686&form=6&db=m A systematic review to establish the frequency of cyclooxygenase-2 expression in normal breast epithelium, ductal carcinoma in situ, microinvasive carcinoma of the breast and invasive breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21678409&form=6&db=m Interplay between membrane lipid peroxidation, transglutaminase activity and cyclooxygenase 2 expression in the tissue adjoining to breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21681369&form=6&db=m Prostaglandin E(2) (PGE (2)) suppresses natural killer cell function primarily through the PGE(2) receptor EP4. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21683430&form=6&db=m Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21725607&form=6&db=m Stephania delavayi Diels. inhibits breast carcinoma proliferation through the p38 MAPK/NF-?B/COX-2 pathway. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21728052&form=6&db=m COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21771729&form=6&db=m Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21787643&form=6&db=m Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21792195&form=6&db=m Radiation-enhancement of MDA-MB-231 breast cancer cell invasion prevented by a cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813027&form=6&db=m Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21822285&form=6&db=m Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21840784&form=6&db=m Cyclooxygenase-2 immunoexpression in breast cancer: Progesterone receptor influence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21857970&form=6&db=m Quercetin Suppresses Cyclooxygenase-2 Expression and Angiogenesis through Inactivation of P300 Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21907301&form=6&db=m COX-2 and PGE2-dependent immunomodulation in breast cancer. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21920875&form=6&db=m p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21953546&form=6&db=m Noninvasive imaging identifies new roles for cyclooxygenase-2 in choline and lipid metabolism of human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21971413&form=6&db=m Rottlerin enhances IL-1?-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002714&form=6&db=m Prostaglandin E2 EP receptors as therapeutic targets in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22006370&form=6&db=m Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22037828&form=6&db=m Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22161831&form=6&db=m Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22199296&form=6&db=m Human brain endothelial cell-derived COX-2 facilitates extravasation of breast cancer cells across the blood-brain barrier. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22199301&form=6&db=m Impact of cyclooxygenase-2 in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22213327&form=6&db=m Influence of calcitriol on prostaglandin- and vitamin D-metabolising enzymes in benign and malignant breast cell lines. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22242594&form=6&db=m Antitumor effect of a generation 4 polyamidoamine dendrimer/cyclooxygenase-2 antisense oligodeoxynucleotide complex on breast cancer in vitro and in vivo. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22252523&form=6&db=m Antiproliferative effects of selective cyclooxygenase-2 inhibitor modulated by nimotuzumab in estrogen-dependent breast cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22286316&form=6&db=m Cyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22306906&form=6&db=m Modulation of host natural killer cell functions in breast cancer via prostaglandin E2 receptors EP2 and EP4. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22329896&form=6&db=m Inhibition of cell survival, cell cycle progression, tumor growth and cyclooxygenase-2 activity in MDA-MB-231 breast cancer cells by camphorataimide B. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22333315&form=6&db=m Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22335196&form=6&db=m Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells. causal interaction,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22353218&form=6&db=m Immunohistochemical expression of epithelial and stromal immunomodulatory signalling molecules is a prognostic indicator in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22362382&form=6&db=m Combination of EGFR and COX-2 inhibitors in breast cancer patient. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22384268&form=6&db=m Structure Based Design and Synthesis of Peptide Inhibitor of Human LOX-12: In Vitro and In Vivo Analysis of a Novel Therapeutic Agent for Breast Cancer. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22527932&form=6&db=m Clinical relevance of cyclooxygenase-2 and matrix metalloproteinases (MMP-2 and MT1-MMP) in human breast cancer tissue. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22641101&form=6&db=m Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22664238&form=6&db=m Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22718198&form=6&db=m Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22740037&form=6&db=m Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-?B activation in TPA-induced breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22740976&form=6&db=m Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22822908&form=6&db=m Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22927520&form=6&db=m Use of Aspirin, Other Nonsteroidal Anti-Inflammatory Drugs, and Acetaminophen and Postmenopausal Breast Cancer Incidence. diagnostic usage,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22936450&form=6&db=m Expression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impact. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22938493&form=6&db=m Phorbol Ester TPA Modulates Chemoresistance in the Drug Sensitive Breast Cancer Cell Line MCF-7 by Inducing Expression of Drug Efflux Transporter ABCG2. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971613&form=6&db=m 1,25-Dihydroxyvitamin D3 inhibits growth of the breast cancer cell line MCF-7 and downregulates cytochrome P4501B1 through the COX-2/PGE2 pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22997041&form=6&db=m Proteomic profiling of cancer stem cells derived from primary tumors of HER2/Neu transgenic mice. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23027181&form=6&db=m Angiotensin-converting enzyme inhibitors enhance the effect of cyclooxygenase inhibitors on breast cancer: a nationwide case-control study. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23029485&form=6&db=m Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23098208&form=6&db=m p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23102197&form=6&db=m [Neoplastic effect of indomethacin in N-methyl-N-nitrosourea induced mammary carcinogenesis in female rats]. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23150665&form=6&db=m Cyclooxygenase-2 induces the expression of the alpha 2,3 sialyltransferase-3 (ST3Gal-I) in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162077&form=6&db=m Evidence of an autocrine role for leptin and leptin receptor in human breast cancer. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23179791&form=6&db=m Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells. ongoing research,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23180004&form=6&db=m Immunohistochemical molecular expression profile of metastatic brain tumor for potent personalized medicine. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23249419&form=6&db=m Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in Vitro and in Vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23272114&form=6&db=m Effects of enriched environment on COX-2, leptin and eicosanoids in a mouse model of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275522&form=6&db=m Cyclooxygenase-2 enzyme induces the expression of the ?-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23344392&form=6&db=m Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23374284&form=6&db=m MiRNA-26b inhibits proliferation by targeting PTGS2 in breast cancer. therapeutic application,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401151&form=6&db=m The Inhibitory Effect of Roasted Licorice Extract on Human Metastatic Breast Cancer Cell-Induced Bone Destruction. ongoing research,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23402310&form=6&db=m Overexpression of p65 attenuates celecoxib-induced cell death in MDA-MB-231 human breast cancer cell line. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23432930&form=6&db=m Correction: MiRNA-26b inhibits proliferation by targeting PTGS2 in breast cancer. therapeutic application,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23434145&form=6&db=m Molecular markers of therapeutic resistance in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489848&form=6&db=m Different role of COX-2 and angiogenesis in canine inflammatory and non-inflammatory mammary cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520664&form=6&db=m Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23566419&form=6&db=m A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in primary breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23667623&form=6&db=m Cyclooxygenase-2 inhibition blocks M2 macrophage differentiation and suppresses metastasis in murine breast cancer model. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23771849&form=6&db=m COX-2 promotes breast cancer cell radioresistance via p38/MAPK-mediated cellular anti-apoptosis and invasiveness. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23783392&form=6&db=m Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23792017&form=6&db=m Cyclooxygenase-2 169C>G and 8473T>C gene polymorphisms and prostaglandin E2 level in breast cancer: A case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23846978&form=6&db=m Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis. unassigned -
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23955549&form=6&db=m Expressions of ER, PR, HER-2, COX-2, and VEGF in Primary and Relapsed/Metastatic Breast Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24004819&form=6&db=m Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24065467&form=6&db=m The importance of COX-2 expression as prognostic factor in early breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24065532&form=6&db=m Starfish polysaccharides downregulate metastatic activity through the MAPK signaling pathway in MCF-7 human breast cancer cells. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24206214&form=6&db=m Nexrutine inhibits survival and induces g1 cell cycle arrest, which is associated with apoptosis or autophagy depending on the breast cancer cell line. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24220687&form=6&db=m Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24260046&form=6&db=m Association of osteopontin and cyclooxygenase-2 expression with breast cancer subtypes and their use as potential biomarkers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24281828&form=6&db=m Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24325753&form=6&db=m Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24374147&form=6&db=m Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24402873&form=6&db=m Lack of association between cyclooxygenase 2-765G/C gene polymorphism and breast cancer risk in Ahvaz, west-south Iran. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24418973&form=6&db=m Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24434582&form=6&db=m Integrin ?3?1 controls mRNA splicing that determines Cox-2 mRNA stability in breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24518566&form=6&db=m Physiological COX-2 Expression in Breast Epithelium Associates with COX-2 Levels in Ductal Carcinoma in Situ and Invasive Breast Cancer in Young Women. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535190&form=6&db=m COX-2 silencing enhances tamoxifen antitumor activity in breast cancer in vivo and in vitro. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24590894&form=6&db=m Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24599585&form=6&db=m Impact of COX2 genotype, ER status and body constitution on risk of early events in different treatment groups of breast cancer patients. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24614081&form=6&db=m COX-2 drives metastatic breast cells from brain lesions into the cerebrospinal fluid and systemic circulation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24659686&form=6&db=m COX-2 overexpression increases malignant potential of human glioma cells through Id1. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24669166&form=6&db=m Role of Cyclooxygenase 2 (COX-2) in Prognosis of Breast Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24708725&form=6&db=m Post-diagnostic prescriptions for low-dose aspirin and breast cancer-specific survival: a nested case-control study in a breast cancer cohort from the UK Clinical Practice. therapeutic application,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24716145&form=6&db=m Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice. ongoing research,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24729783&form=6&db=m Synergistic Antiproliferative Effects of Combined ? -Tocotrienol and PPAR ? Antagonist Treatment Are Mediated through PPAR ? -Independent Mechanisms in Breast Cancer Cells. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24789723&form=6&db=m Cyclooxygenase-2 Polymorphisms and Breast Cancer Associated Risk in Pakistani Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24826080&form=6&db=m Functional promoter -765 G?>?C variant in COX-2 gene is associated with the susceptibility of breast cancer in Chinese Han women. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24859472&form=6&db=m Metastatic potential in MDA-MB-231 human breast cancer cells is inhibited by proton beam irradiation via the Akt/nuclear factor-?B signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922641&form=6&db=m Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24923427&form=6&db=m Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24927687&form=6&db=m Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24950714&form=6&db=m Expression of integrin ?3?1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24965402&form=6&db=m Expression of cyclooxygenase-2 and Bcl-2 in breast cancer and their relationship with triple-negative disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24981602&form=6&db=m Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054056&form=6&db=m Cyclooxygenase-2 expression in non-metastatic triple-negative breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25060643&form=6&db=m Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25068292&form=6&db=m Differential peripheral blood gene expression profile based on Her2 expression on primary tumors of breast cancer patients. unassigned -
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25077370&form=6&db=m COX-2, p16 and Ki67 expression in DCIS, microinvasive and early invasive breast carcinoma with extensive intraductal component. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25094029&form=6&db=m Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25118473&form=6&db=m Breast cancer--new aspects of tumor biology: are calcitriol and cyclooxygenase-2 possible targets for breast cancer? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25125682&form=6&db=m NSAID use reduces breast cancer recurrence in overweight and obese women: role of prostaglandin-aromatase interactions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25133423&form=6&db=m Inflammatory lymphangiogenesis in postpartum breast tissue remodeling. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25133426&form=6&db=m Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25142612&form=6&db=m Apoptotic effects of two COX-2 inhibitors on breast adenocarcinoma cells through COX-2 independent pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202381&form=6&db=m Effect of cycloxygenase-2 silencing on the malignant biological behavior of MCF-7 breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25214156&form=6&db=m Urinary prostaglandin E2 metabolite and breast cancer risk. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25214704&form=6&db=m Association of the three common SNPs of cyclooxygenase-2 gene (rs20417, rs689466, and rs5275) with the susceptibility of breast cancer: an updated meta-analysis involving 34,590 subjects. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25242400&form=6&db=m Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25256221&form=6&db=m NDRG2 controls COX-2/PGE?-mediated breast cancer cell migration and invasion. ongoing research,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25269624&form=6&db=m Stromal, rather than epithelial cyclooxygenase-2 (COX-2) expression is associated with overall survival of breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25302170&form=6&db=m Cyclooxygenase-2 and the inflammogenesis of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323004&form=6&db=m Effects and mechanism of downregulation of COX?2 expression by RNA interference on proliferation and apoptosis of human breast cancer MCF?7 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25368279&form=6&db=m Evaluation of the contribution of cyclooxygenase 2 genotypes to breast cancer in Taiwan. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25374215&form=6&db=m Targeting of COX-2 expression by recombinant adenovirus shRNA attenuates the malignant biological behavior of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433948&form=6&db=m Five COX-2 gene polymorphisms and risk of breast cancer: an updated meta-analysis based on 19 case-control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25476497&form=6&db=m Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25511800&form=6&db=m Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25520090&form=6&db=m Lack of association of the cyclooxygenase-2 gene 8473T>C polymorphism with breast cancer risk: a meta-analysis. ongoing research,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25520137&form=6&db=m Silencing of COX-2 by RNAi modulates epithelial-mesenchymal transition in breast cancer cells partially dependent on the PGE2 cascade. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25520577&form=6&db=m Lack of association between COX-2 8473T>C polymorphism and breast cancer risk: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25553436&form=6&db=m Curcumin as an Adjuvant to Breast Cancer Treatment. causal interaction,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587329&form=6&db=m Celecoxib Up Regulates the Expression of Drug Efflux Transporter ABCG2 in Breast Cancer Cell Lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25589172&form=6&db=m Effect of COX-2 inhibitors and other non-steroidal inflammatory drugs on breast cancer risk: a meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25636590&form=6&db=m Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients. unassigned -
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25667510&form=6&db=m Combined Treatment of Breast Cancer Cell Lines with Vitamin D and COX-2 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25691572&form=6&db=m Roles of the cyclooxygenase 2-matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701047&form=6&db=m COX-2 dependent regulation of mechanotransduction in human breast cancer cells. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25733698&form=6&db=m COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25743830&form=6&db=m Cyclooxygenase-2 expression in invasive breast carcinomas of no special type and correlation with pathological profiles suggest a role in tumorigenesis rather than cancer progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25754990&form=6&db=m Inhibition of PKC-induced COX-2 and IL-8 Expression in Human Breast Cancer Cells by Glucosamine. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25773924&form=6&db=m 15-Deoxy-?12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25849942&form=6&db=m Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25863259&form=6&db=m Protective effects of dendrosomal curcumin on an animal metastatic breast tumor. ongoing research,unassigned 2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25889730&form=6&db=m Opposing roles for mammary epithelial-specific PPAR? signaling and activation during breast tumour progression. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26067757&form=6&db=m Pro-migratory actions of the prostacyclin receptor in human breast cancer cells that over-express cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26139640&form=6&db=m Celecoxib Versus Diclofenac in Mild to Moderate Depression Management Among Breast Cancer Patients: A Double-Blind, Placebo-Controlled, Randomized Trial. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26193871&form=6&db=m New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26227474&form=6&db=m Increased COX-2 expression in epithelial and stromal cells of high mammographic density tissues and in a xenograft model of mammographic density. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26275572&form=6&db=m A window-of-opportunity biomarker study of etodolac in resectable breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26359357&form=6&db=m Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26416248&form=6&db=m RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26431176&form=6&db=m Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26442202&form=6&db=m Targeting the COX-2 Pathway to Improve Therapeutic Response in the Obese Breast Cancer Patient Population. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26456774&form=6&db=m Mechanisms of dihydrotestosterone action on resveratrol-induced anti-proliferation in breast cancer cells with different ER? status. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26530254&form=6&db=m A novel aspirin prodrug inhibits NF?B activity and breast cancer stem cell properties. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680798&form=6&db=m Expression of Cyclooxygenase-2 in Human Breast Carcinoma: Relevance to Tumor Angiogenesis and Expression of Estrogen Receptor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26723915&form=6&db=m COX-2 inhibitors: a novel strategy in the management of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26791786&form=6&db=m Cyclooxygenase-2 (COX2) and p53 protein expression are interdependent in breast cancer but not associated with clinico-pathological surrogate subtypes, tumor aggressiveness and patient survival. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807319&form=6&db=m Association of EP2 receptor and SLC19A3 in regulating breast cancer metastasis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26910917&form=6&db=m IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs. diagnostic usage,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27000374&form=6&db=m COX-2 modulates mammary tumor progression in response to collagen density. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27007644&form=6&db=m Low-dose aspirin, non-steroidal anti-inflammatory drugs, selective COX-2 inhibitors and breast cancer recurrence. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27007742&form=6&db=m Comparative Evaluation of Nimesulide-Loaded Nanoparticles for Anticancer Activity Against Breast Cancer Cells. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27035791&form=6&db=m Gold-conjugated resveratrol nanoparticles attenuate the invasion and MMP-9 and COX-2 expression in breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27176787&form=6&db=m Suppressive effects of a proton beam on tumor growth and lung metastasis through the inhibition of metastatic gene expression in 4T1 orthotopic breast cancer model. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27235711&form=6&db=m Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27257388&form=6&db=m Upregulation of Cyclooxygenase-2/Prostaglandin E2 (COX-2/PGE2) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270654&form=6&db=m Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301070&form=6&db=m COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis. ongoing research,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323060&form=6&db=m Tristetraprolin: a novel mediator of the anticancer properties of resveratrol. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27420617&form=6&db=m [The connection of miR-21 and miR-155 with regulation of 15-HPGDH mRNA in human breast cancer cells]. causal interaction,unassigned 2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27436928&form=6&db=m Impact of cyclooxygenase-2 over-expression on the prognosis of breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27436929&form=6&db=m Impact of cyclooxygenase-2 over-expression on the prognosis of breast cancer patients. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27542890&form=6&db=m Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27610157&form=6&db=m Design, Synthesis and Biological Evaluation of4-(Imidazolylmethyl)-2-(4-methylsulfonyl phenyl)-Quinoline Derivatives as Selective COX-2 Inhibitors and In-vitro Anti-breast Cancer Agents. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27616330&form=6&db=m Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. causal interaction,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27632554&form=6&db=m The prognostic impact of COX-2 expression in breast cancer depends on oral contraceptive history, preoperative NSAID use, and tumor size. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713317&form=6&db=m The Role of Non-Steroidal Anti-Inflammatory Drugs in the Chemoprevention of Breast Cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27779707&form=6&db=m ST3Gal III modulates breast cancer cell adhesion and invasion by altering the expression of invasion-related molecules. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27821648&form=6&db=m Novel augmentation by bufalin of protein kinase C-induced cyclooxygenase-2 and IL-8 production in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27835884&form=6&db=m Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27903840&form=6&db=m Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27935990&form=6&db=m Hyperalgesia and Persistent Pain after Breast Cancer Surgery: A Prospective Randomized Controlled Trial with Perioperative COX-2 Inhibition. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27940576&form=6&db=m Aspirin Suppresses Growth in PI3K-Mutant Breast Cancer by Activating AMPK and Inhibiting mTORC1 Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27967239&form=6&db=m Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis. therapeutic application,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27990091&form=6&db=m Novel applications of COX-2 inhibitors, metformin, and statins for the primary chemoprevention of breast cancer. therapeutic application,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27994517&form=6&db=m Cyclooxygenase-2 in tumor-associated macrophages promotes metastatic potential of breast cancer cells through Akt pathway. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27999206&form=6&db=m Clinicopathological and prognostic significance of COX-2 immunohistochemical expression in breast cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28002200&form=6&db=m Association between expression of inflammatory markers in normal breast tissue and mammographic density among premenopausal and postmenopausal women. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28029661&form=6&db=m Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28054666&form=6&db=m Cyclooxygenase-2 regulates TGF?-induced cancer stemness in triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056899&form=6&db=m PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28152501&form=6&db=m Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28240006&form=6&db=m Effects of Six Weeks Endurance Training and Aloe Vera Supplementation on COX-2 and VEGF Levels in Mice with Breast Cancer causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28393249&form=6&db=m EpCAM and COX?2 expression are positively correlated in human breast cancer. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28486908&form=6&db=m Synthesis of Hybrids of Dihydropyrimidine and Pyridazinone as potential anti-Breast Cancer agents. therapeutic application,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28490464&form=6&db=m Perioperative COX-2 and ?-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28522609&form=6&db=m Coagulation factor VIIa-mediated protease-activated receptor 2 activation leads to ?-catenin accumulation via the AKT/GSK3? pathway and contributes to breast cancer progression. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28571770&form=6&db=m Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28597105&form=6&db=m Role of Aspirin in Breast Cancer Survival. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28605338&form=6&db=m Effect of Hispolon from Phellinus lonicerinus (Agaricomycetes) on Estrogen Receptors, Aromatase, and Cyclooxygenase II in MCF-7 Breast Cancer Cells. ongoing research,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28618256&form=6&db=m Cigarette Smoke Regulates Calcium-Independent Phospholipase A2 Metabolic Pathways in Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28663087&form=6&db=m Superiority of aromatase inhibitor and cyclooxygenase-2 inhibitor combined delivery: Hyaluronate-targeted versus PEGylated protamine nanocapsules for breast cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28666869&form=6&db=m Celecoxib induced apoptosis against different breast cancer cell lines by down-regulated NF-?B pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28709031&form=6&db=m Bisphenol A induces COX-2 through the mitogen-activated protein kinase pathway and is associated with levels of inflammation-related markers in elderly populations. causal interaction,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808873&form=6&db=m Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28844858&form=6&db=m miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-?B/COX-2 activation. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28906164&form=6&db=m Comparative pharmacokinetics study of anastrozole after single administration and combination with celecoxib. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927045&form=6&db=m Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28964785&form=6&db=m CXCR2 promotes breast cancer metastasis and chemoresistance via suppression of AKT1 and activation of COX2. therapeutic application,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29202630&form=6&db=m Concurrent new drug prescriptions and prognosis of early breast cancer: studies using the Danish Breast Cancer Group clinical database. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29250535&form=6&db=m HPV16 E6 Promotes Breast Cancer Proliferation via Upregulation of COX-2 Expression. causal interaction,unassigned 2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321183&form=6&db=m causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321644&form=6&db=m COX-2 induces oncogenic micro RNA miR655 in human breast cancer. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29367765&form=6&db=m Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379. therapeutic application,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29377693&form=6&db=m Antibodies as Carrier Molecules: Encapsulating Anti-Inflammatory Drugs inside Herceptine. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29429545&form=6&db=m The Presence of Cyclooxygenase 2, Tumor-Associated Macrophages, and Collagen Alignment as Prognostic Markers for Invasive Breast Carcinoma Patients. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29501042&form=6&db=m Clostridium difficile toxin B recombinant protein inhibits tumor growth and induces apoptosis through inhibiting Bcl-2 expression, triggering inflammatory responses and activating C-erbB-2 and Cox-2 expression in breast cancer mouse model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29587668&form=6&db=m Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29596308&form=6&db=m EP4 as a Therapeutic Target for Aggressive Human Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29609579&form=6&db=m Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29661238&form=6&db=m EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29736687&form=6&db=m Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767863&form=6&db=m Influence of VEGF, COX-2, and MMP-9 expression on the molybdenum-targeted X-ray in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858743&form=6&db=m Roles of prostaglandins in tumor-associated lymphangiogenesis with special reference to breast cancer. ongoing research,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29859524&form=6&db=m [Effect of lupeol on migration and invasion of human breast cancer MDA-MB-231 cells and its mechanism]. ongoing research,unassigned 2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29923556&form=6&db=m Regulating the Golgi apparatus by co-delivery of a COX-2 inhibitor and Brefeldin A for suppression of tumor metastasis. therapeutic application,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928417&form=6&db=m HPV16 E7 increases COX-2 expression and promotes the proliferation of breast cancer. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29937181&form=6&db=m Effects of anesthetic interventions on breast cancer behavior, cancer-related patient outcomes, and postoperative recovery. therapeutic application,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30030837&form=6&db=m The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30051683&form=6&db=m COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30083255&form=6&db=m Suspension state promotes metastasis of breast cancer cells by up-regulating cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30152521&form=6&db=m Understanding the tumour microenvironment communication network from a NOS2/COX2 perspective. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30314513&form=6&db=m Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30338705&form=6&db=m Lactoferrin-tagged quantum dots-based theranostic nanocapsules for combined COX-2 inhibitor/herbal therapy of breast cancer. therapeutic application,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30339576&form=6&db=m The effect of NSAIDs exposure on breast cancer risk in female patients with autoimmune diseases. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30362513&form=6&db=m Nonaspirin NSAIDs and contralateral breast cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30496661&form=6&db=m Cannabidiolic Acid-Mediated Interference with AP-1 Transcriptional Activity in MDA-MB-231 Breast Cancer Cells. ongoing research,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30539699&form=6&db=m Madhuca indica Inhibits Breast Cancer Cell Proliferation by Modulating COX-2 Expression. unassigned -
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30627539&form=6&db=m Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30702971&form=6&db=m Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30747082&form=6&db=m Two Novel tri-aryl Derivatives Attenuate the Invasion- Promoting Effects of Stromal Mesenchymal Stem Cells on Breast Cancer. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30769266&form=6&db=m Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations. causal interaction,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847405&form=6&db=m Studies of postpartum mammary gland involution reveal novel pro-metastatic mechanisms. causal interaction,unassigned 3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930224&form=6&db=m Inhibition of PSMD4 blocks the tumorigenesis of hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30999962&form=6&db=m Regular use of aspirin and other non-steroidal anti-inflammatory drugs and breast cancer risk for women at familial or genetic risk: a cohort study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31185986&form=6&db=m Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31195426&form=6&db=m Increased expression of ZNF 703 in breast cancer tissue: An opportunity for RNAi-NSAID combinatorial therapy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31203442&form=6&db=m Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31277414&form=6&db=m Mir526b and Mir655 Promote Tumour Associated Angiogenesis and Lymphangiogenesis in Breast Cancer. unassigned -
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31289003&form=6&db=m Expression of PCNA, Ki-67 and COX-2 in breast cancer based on DCE-MRI image information. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31300611&form=6&db=m Activation of HIF-1? by ?-Opioid Receptors Induces COX-2 Expression in Breast Cancer Cells and Leads to Paracrine Activation of Vascular Endothelial Cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31349508&form=6&db=m Design of colloidal drug carriers of celecoxib for use in treatment of breast cancer and leukemia. therapeutic application,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31494294&form=6&db=m A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31506784&form=6&db=m Beta-ionone-inhibited proliferation of breast cancer cells by inhibited COX-2 activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534346&form=6&db=m EP3 receptor antagonist L798,106 reduces proliferation and migration of SK-BR-3 breast cancer cells. causal interaction,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31623608&form=6&db=m pH and redox dual-responsive nanoparticles based on disulfide-containing poly(?-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31759380&form=6&db=m Association between Cyclooxygenase-2 and Indoleamine 2,3-Dioxygenase Expression in Breast Cancer Patients from Pakistan. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31783895&form=6&db=m Cross-talk between SIM2s and NF?B regulates cyclooxygenase 2 expression in breast cancer. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949822&form=6&db=m Expression of VEGF, COX-2 and MMP-9 in breast cancer and their relationship with ultrasound findings. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32042261&form=6&db=m Association between ABCB1, ABCG2 carrier protein and COX-2 enzyme gene polymorphisms and breast cancer risk in a Turkish population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32085795&form=6&db=m Cytoplasmic PPAR? is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32238697&form=6&db=m Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor ?/? abrogation. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32376713&form=6&db=m Detection of COX-2 in liquid biopsy in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32688115&form=6&db=m p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32698885&form=6&db=m Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850312&form=6&db=m Lack of Androgen Receptor Expression Selects for Basal-Like Phenotype and Is a Predictor of Poor Clinical Outcome in Non-Metastatic Triple Negative Breast Cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32858862&form=6&db=m Valuing Bioactive Lipids from Green, Red and Brown Macroalgae from Aquaculture, to Foster Functionality and Biotechnological Applications. unassigned -
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32891712&form=6&db=m Co-administration of sulforaphane and doxorubicin attenuates breast cancer growth by preventing the accumulation of myeloid-derived suppressor cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32897000&form=6&db=m Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX-2 and PD-L1. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32931930&form=6&db=m Growth inhibitory and anti-metastatic activity of epithelial cell adhesion molecule targeted three-way junctional delta-5-desaturase siRNA nanoparticle for breast cancer therapy. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32988253&form=6&db=m Identification of genes and miRNAs in paclitaxel treatment for breast cancer. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33084091&form=6&db=m Carotenoid isolates of Spondias mombin demonstrate anticancer effects in DMBA-induced breast cancer in Wistar rats through X-linked inhibitor of apoptosis protein (XIAP) antagonism and anti-inflammation. ongoing research,unassigned 2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147051&form=6&db=m Expression of COX-2, p16, and Ki67 in the range from normal breast tissue to breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33149754&form=6&db=m Deciphering of Key Pharmacological Pathways of Poria Cocos Intervention in Breast Cancer Based on Integrated Pharmacological Method. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33223820&form=6&db=m Prognostic Significance of Prostaglandin-Endoperoxide Synthase-2 Expressions in Human Breast Carcinoma: A Multiomic Approach. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33358854&form=6&db=m Virtual screening of the multi-gene regulatory molecular mechanism of Si-Wu-tang against non-triple-negative breast cancer based on network pharmacology combined with experimental validation. diagnostic usage,unassigned 2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33402361&form=6&db=m Inflammation Mediates the Development of Aggressive Breast Cancer Following Radiotherapy. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33588911&form=6&db=m Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33607360&form=6&db=m Gancochlearols E - I, meroterpenoids from Ganoderma cochlear against COX-2 and triple negative breast cancer cells and the absolute configuration assignment of ganomycin K. ongoing research,unassigned 1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33668160&form=6&db=m Prostaglandin E2 Receptor 4 (EP4) as a Therapeutic Target to Impede Breast Cancer-Associated Angiogenesis and Lymphangiogenesis. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33800915&form=6&db=m MYLK and PTGS1 Genetic Variations Associated with Osteoporosis and Benign Breast Tumors in Korean Women. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33801351&form=6&db=m 15-Deoxy-?12,14-prostaglandin J2 Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257723&form=6&db=m Metformin suppresses breast cancer growth via inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34335799&form=6&db=m Integrative Bioinformatics Study of Tangeretin Potential Targets for Preventing Metastatic Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34389281&form=6&db=m MicroRNA and cyclooxygenase-2 in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34390295&form=6&db=m Clinical outcome of dogs diagnosed with canine inflammatory mammary cancer treated with metronomic cyclophosphamide, a cyclooxygenase-2 inhibitor and toceranib phosphate. therapeutic application,unassigned 4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34515014&form=6&db=m Molecular and Metabolomic Investigation of Celecoxib Antiproliferative Activity in Mono-and Combination Therapy Against Breast Cancer Cell Models. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34535685&form=6&db=m Iminodibenzyl induced redirected COX-2 activity inhibits breast cancer progression. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Breast Neoplasms, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19632843&form=6&db=m Survivin and COX-2 expression in male breast carcinoma. unassigned -
1.14.99.1 Bronchial Hyperreactivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1937886&form=6&db=m New antiasthmatic drugs from traditional medicine? ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1309376&form=6&db=m Increased excretion of leukotriene E4 during aspirin-induced asthma. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2883941&form=6&db=m Labetalol protects against the potentiation by propranolol of the bronchospasm to norepinephrine in guinea-pigs. unassigned -
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3918485&form=6&db=m Arachidonic acid metabolism and inhibition of cyclooxygenase in platelets from asthmatic subjects with aspirin intolerance. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6152379&form=6&db=m The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation. unassigned -
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6420780&form=6&db=m [Role of arachidonic acid (ETE) and its metabolites in the pathogenesis of bronchial spasm. I. Metabolites formed under the effect of cyclooxygenase] unassigned -
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7079897&form=6&db=m Near-fatal bronchospasm in an asthmatic patient following ingestion of flurbiprofen. A case report. unassigned -
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7282491&form=6&db=m SRS-A mediated bronchospasm by pharmacologic modification of lung anaphylaxis in vivo. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8256883&form=6&db=m The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8620177&form=6&db=m [The influence of misoprostol on post-aspirin bronchoconstriction in patients with aspirin sensitive asthma] causal interaction,unassigned 2,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8727270&form=6&db=m The influence of misoprostol (synthetic analogue of prostaglandin E1) on aspirin-induced bronchoconstriction in aspirin-sensitive asthma. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8927789&form=6&db=m [Iatrogenic drug-induced bronchospasm, cough, and bronchiolitis. Etiologic and physiopathologic aspects] therapeutic application,unassigned 3,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12925478&form=6&db=m Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681964&form=6&db=m Severe bronchospasm after parenteral parecoxib: cyclooxygenase-2 inhibitors: not the answer yet. therapeutic application,unassigned 4,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16579869&form=6&db=m Mechanisms of aspirin sensitivity. causal interaction,unassigned 2,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20091477&form=6&db=m [COX-2 Inhibitors for the management of postoperative pain] therapeutic application,unassigned 3,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21217919&form=6&db=m Aspirin-exacerbated respiratory disease: evaluation and management. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663486&form=6&db=m Update on aspirin desensitization for chronic rhinosinusitis with polyps in aspirin-exacerbated respiratory disease (AERD). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27712763&form=6&db=m Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease. causal interaction,unassigned 3,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883727&form=6&db=m Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Bronchial Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30506046&form=6&db=m Pathogenesis of NSAID-induced reactions in aspirin-exacerbated respiratory disease. causal interaction,unassigned 1,0
1.14.99.1 Bronchiectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2203618&form=6&db=m Attenuating effect of a thromboxane synthetase inhibitor (OKY-046) on bronchial responsiveness to methacholine is specific to bronchial asthma. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Bronchiolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476277&form=6&db=m Cyclooxygenase-2 expression in experimental post-transplant obliterative bronchiolitis. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Bronchiolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24064666&form=6&db=m Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Bronchitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2192187&form=6&db=m [Thromboxane A2 could be involved in bronchial hyperresponsiveness to methacholine in asthmatic subjects but not in bronchitic subjects] ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Bronchitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2203618&form=6&db=m Attenuating effect of a thromboxane synthetase inhibitor (OKY-046) on bronchial responsiveness to methacholine is specific to bronchial asthma. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Bronchitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8575575&form=6&db=m Prostanoids and cough response to capsaicin in asthma and chronic bronchitis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Bronchitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21428715&form=6&db=m Involvement of mitogen-activated protein kinase activation in cyclooxygenase-2 and transforming growth factor-? production in alveolar macrophage from chronic bronchitis rats. ongoing research,unassigned 4,0
1.14.99.1 Bronchitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21837981&form=6&db=m [Effects of mangiferin on cytokines in rats with chronic bronchitis and expression of macrophage COX-2 in mice]. ongoing research,unassigned 2,0
1.14.99.1 Bronchopneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19906385&form=6&db=m 5-lipoxygenase and cyclooxygenase-2 in porcine parasitic bronchopneumonia: immunohistochemical and biochemical investigations. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10813584&form=6&db=m Cyclooxygenase-2 in human perinatal lung. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23624331&form=6&db=m Cyclooxygenase-2 in newborn hyperoxic lung injury. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24273102&form=6&db=m Cyclooxygenase-2 inhibition partially protects against 60% O2 -mediated lung injury in neonatal rats. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Bronchopulmonary Dysplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29952221&form=6&db=m Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice. causal interaction,unassigned 4,0
1.14.99.1 Brucellosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28018318&form=6&db=m COX-2 Inhibition Reduces Brucella Bacterial Burden in Draining Lymph Nodes. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Brucellosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33091457&form=6&db=m Prostaglandin I2 (PGI2) inhibits Brucella abortus internalization in macrophages via PGI2 receptor signaling, and its analogue affects immune response and disease outcome in mice. causal interaction,unassigned 2,0
1.14.99.1 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16104877&form=6&db=m Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21980345&form=6&db=m Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Burkitt Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Bursitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16779827&form=6&db=m Stromal cell-derived factor 1 (SDF-1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti-inflammatory agents. ongoing research,unassigned 4,0
1.14.99.1 Bursitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22999851&form=6&db=m Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Bursitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23400718&form=6&db=m Comparative study of the clinical efficacy of the selective cyclooxygenase-2 inhibitor celecoxib compared with loxoprofen in patients with frozen shoulder. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Bursitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24261771&form=6&db=m Comparative study of the clinical efficacy of the selective cyclooxygenase-2 inhibitor celecoxib compared with loxoprofen in patients with frozen shoulder. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Candidemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8335578&form=6&db=m TNF-alpha and cyclooxygenase metabolites do not modulate C. albicans septic shock with disseminated candidiasis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Candidiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8335578&form=6&db=m TNF-alpha and cyclooxygenase metabolites do not modulate C. albicans septic shock with disseminated candidiasis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Capsule Opacification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17563718&form=6&db=m Prevention of posterior capsular opacification through cyclooxygenase-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1315625&form=6&db=m Effects of aspirin on 1,2-dimethylhydrazine-induced colonic carcinogenesis. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1902395&form=6&db=m Effects of the prostaglandin synthetase inhibitor indomethacin on tumorigenesis, tumor proliferation, cell kinetics, and receptor contents of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in Sprague-Dawley rats fed a high- or low-fat diet. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2295078&form=6&db=m Effect of flurbiprofen and 16,16-dimethyl prostaglandin E2 on gastrointestinal tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats: glandular epithelium of stomach and duodenum. therapeutic application,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2502321&form=6&db=m A comparison of the effects of the prostaglandin synthesis inhibitors indomethacin and carprofen on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats fed different amounts of essential fatty acid. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115924&form=6&db=m Involvement of prostaglandin E2 in bile acid-caused promotion of colon carcinogenesis and anti-promotion by the cyclooxygenase inhibitor indomethacin. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3731063&form=6&db=m Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide initiation and sodium saccharin promotion of urinary bladder carcinogenesis in male F344 rats. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3928186&form=6&db=m DNA adducts formed by ring-oxidation of the carcinogen 2-naphthylamine with prostaglandin H synthase in vitro and in the dog urothelium in vivo. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6407750&form=6&db=m Effect of the prostaglandin synthetase inhibitor indomethacin on 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats fed different levels of fat. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6413679&form=6&db=m Comparative effects of prostaglandin H synthase-catalyzed binding of two 5-nitrofuran urinary bladder carcinogens. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7641194&form=6&db=m Expression of cyclooxygenase-1 and -2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7757981&form=6&db=m Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7777237&form=6&db=m The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7812955&form=6&db=m Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7818763&form=6&db=m Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8052480&form=6&db=m Comparative effects of piroxicam and esculetin on incidence, proliferation, and cell kinetics of mammary carcinomas induced by 7,12-dimethylbenz[a]anthracene in rats on high- and low-fat diets. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8564967&form=6&db=m Modulating effect of amount and types of dietary fat on colonic mucosal phospholipase A2, phosphatidylinositol-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8566864&form=6&db=m Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8601574&form=6&db=m Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643486&form=6&db=m Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8653697&form=6&db=m Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8840961&form=6&db=m Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8945508&form=6&db=m Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9013627&form=6&db=m Induction of cyclooxygenase-2 expression by peroxisome proliferators and non-tetradecanoylphorbol 12,13-myristate-type tumor promoters in immortalized mouse liver cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9111217&form=6&db=m Benzo[a]pyrene up-regulates cyclooxygenase-2 gene expression in oral epithelial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151799&form=6&db=m Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9230200&form=6&db=m Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9261162&form=6&db=m Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 overexpression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9270014&form=6&db=m Dietary fat and colon cancer: modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288778&form=6&db=m Enhancement of experimental colon cancer by genistein. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9327228&form=6&db=m Experimental models of gene-environment interaction for cancer chemoprevention studies. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9328866&form=6&db=m The inhibitory effect of vitamin E on arachidonic acid metabolism during the process of urethane-induced lung tumorigenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9349689&form=6&db=m Inhibition of cyclooxygenase: a novel approach to cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9349692&form=6&db=m Some perspectives on dietary inhibition of carcinogenesis: studies with curcumin and tea. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9353183&form=6&db=m Recent advances in chemoprevention of cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9439679&form=6&db=m Inhibitory effect of NS-398, a selective cyclooxygenase-2 inhibitor, on azoxymethane-induced aberrant crypt foci in colon carcinogenesis of F344 rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458081&form=6&db=m Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589912&form=6&db=m Chemopreventive effects of NSAIDs against colorectal cancer: regulation of apoptosis and mitosis by COX-1 and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9598866&form=6&db=m Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9685852&form=6&db=m Inhibitory effects of nabumetone, a cyclooxygenase-2 inhibitor, and esculetin, a lipoxygenase inhibitor, on N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9703885&form=6&db=m Cyclooxygenase-2 expression in human adenocarcinoma cell line HT29 cl.19A. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9739782&form=6&db=m Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9743248&form=6&db=m Inhibitory effect of Coptidis Rhizoma and Scutellariae Radix on azoxymethane-induced aberrant crypt foci formation in rat colon. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765305&form=6&db=m Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9785383&form=6&db=m Paradoxical effects of resveratrol on the two prostaglandin H synthases. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9785386&form=6&db=m Effect of hormonal status on the expression of the cyclooxygenase 1 and 2 genes and prostaglandin synthesis in rat mammary glands. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9786845&form=6&db=m Helicobacter pylori up-regulates cyclooxygenase-2 mRNA expression and prostaglandin E2 synthesis in MKN 28 gastric mucosal cells in vitro. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9790545&form=6&db=m Cyclooxygenase-2 inhibitors in tumorigenesis (part I). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9811310&form=6&db=m Cyclooxygenase-2 inhibitors in tumorigenesis (Part II). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815550&form=6&db=m Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831333&form=6&db=m COX-2 and colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846504&form=6&db=m Expression of cyclooxygenase-2 protein in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9855006&form=6&db=m Suppressive effects of nimesulide, a selective inhibitor of cyclooxygenase-2, on azoxymethane-induced colon carcinogenesis in mice. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9858896&form=6&db=m Gene expression of cyclooxygenase-2, group II and cytosolic phospholipase A2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886578&form=6&db=m Meloxicam inhibits the growth of colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927187&form=6&db=m Regulation of cyclooxygenase-2 pathway by HER2 receptor. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051469&form=6&db=m Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10075740&form=6&db=m Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10082276&form=6&db=m Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188882&form=6&db=m Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10197601&form=6&db=m Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10197631&form=6&db=m Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10204802&form=6&db=m Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10213117&form=6&db=m Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10235197&form=6&db=m Cyclooxygenase-2 expression in gastric antral mucosa before and after eradication of Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10363578&form=6&db=m Chemopreventive effect of N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide (NS-398), a selective cyclooxygenase-2 inhibitor, in rat colon carcinogenesis induced by azoxymethane. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398082&form=6&db=m Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10404093&form=6&db=m Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417761&form=6&db=m Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10433483&form=6&db=m Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449029&form=6&db=m Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449516&form=6&db=m Malignant transformation and antineoplastic actions of nonsteroidal antiinflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10455907&form=6&db=m Cyclooxygenase-2 alters transforming growth factor-beta 1 response during intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10465664&form=6&db=m Genetic induction and upregulation of cyclooxygenase (COX) and aromatase (CYP19): an extension of the dietary fat hypothesis of breast cancer. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10506109&form=6&db=m Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10508481&form=6&db=m High expression of cyclooxygenase-2 in macrophages of human colonic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517428&form=6&db=m The relationship between cyclooxygenase-2 expression and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10537280&form=6&db=m Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10557090&form=6&db=m Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10579801&form=6&db=m Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597402&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10604722&form=6&db=m Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10607736&form=6&db=m A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630689&form=6&db=m Role of nitric oxide in cancer biology. ongoing research,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10656441&form=6&db=m Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657949&form=6&db=m Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10665651&form=6&db=m Cyclooxygenase-2 (COX-2) mRNA expression levels in normal lung tissues and non-small cell lung cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10666384&form=6&db=m Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10667579&form=6&db=m Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668483&form=6&db=m Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678579&form=6&db=m Molecular pathology of cyclooxygenase-2 in neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10690533&form=6&db=m Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10702199&form=6&db=m Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10704568&form=6&db=m Cox-2 expression in retinoblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706128&form=6&db=m Transcriptional regulation of cyclooxygenase-2 gene expression: novel effects of nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10708932&form=6&db=m Cancer chemoprevention through interruption of multistage carcinogenesis. The lessons learnt by comparing mouse skin carcinogenesis and human large bowel cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10722929&form=6&db=m Cyclooxygenase-2 and carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766797&form=6&db=m Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3'-untranslated region. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10772828&form=6&db=m Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778945&form=6&db=m Up-regulation of cyclooxygenase-2 in squamous carcinogenesis of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10783318&form=6&db=m Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10786667&form=6&db=m Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10827178&form=6&db=m Feedback control of cyclooxygenase-2 expression through PPARgamma. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10837008&form=6&db=m Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10841517&form=6&db=m Host cyclooxygenase-2 modulates carcinoma growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10842192&form=6&db=m Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873095&form=6&db=m Cyclooxygenase-2 expression is up-regulated in transitional cell carcinoma and its preneoplastic lesions in the human urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874009&form=6&db=m Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10917546&form=6&db=m Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10920275&form=6&db=m Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10931458&form=6&db=m Expression of cyclooxygenase-2 in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10935498&form=6&db=m Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10948340&form=6&db=m Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10965822&form=6&db=m Effect of prostaglandin E1 on vascular endothelial growth factor production by human macrophages and colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980112&form=6&db=m Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987272&form=6&db=m Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005842&form=6&db=m Intracellular unesterified arachidonic acid signals apoptosis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11011115&form=6&db=m Chemoprevention by nimesulide, a selective cyclooxygenase-2 inhibitor, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis in rats. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029518&form=6&db=m Cyclooxygenase expression in the gallbladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11040187&form=6&db=m Leukotrienes induce cell-survival signaling in intestinal epithelial cells. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059772&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062695&form=6&db=m Meloxicam inhibits the growth of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078056&form=6&db=m Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11086200&form=6&db=m Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090259&form=6&db=m Expression of cyclooxygenase-2 and nitrotyrosine in human gastric mucosa before and after Helicobacter pylori eradication. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090967&form=6&db=m Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11091570&form=6&db=m Dietary Fat, Fatty Acids and Breast Cancer. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093779&form=6&db=m Induction of p27(KIP1) as a mechanism underlying NS398-induced growth inhibition in human lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11103814&form=6&db=m Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135226&form=6&db=m COX-2 is expressed in human pulmonary, colonic, and mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11139815&form=6&db=m Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11140899&form=6&db=m Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11150521&form=6&db=m Potential role of group X secretory phospholipase A(2) in cyclooxygenase-2-dependent PGE(2) formation during colon tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11166002&form=6&db=m Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. Extent, mode, and dose dependence of anticancer effects. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11180079&form=6&db=m Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11191059&form=6&db=m The contributions of cyclooxygenase-2 to tumor angiogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11195467&form=6&db=m Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11216473&form=6&db=m COX-2 and iNOS, good targets for chemoprevention of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11228545&form=6&db=m Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11232485&form=6&db=m Chemoprevention of colorectal cancer by non-steroidal anti-inflammatory drugs. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11239502&form=6&db=m Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties? causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245450&form=6&db=m Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11275997&form=6&db=m Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278747&form=6&db=m Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11280748&form=6&db=m Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11285187&form=6&db=m Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11289104&form=6&db=m Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292836&form=6&db=m Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297248&form=6&db=m Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350912&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11370818&form=6&db=m Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11381123&form=6&db=m Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389100&form=6&db=m Transcriptional silencing of Cyclooxygenase-2 by hyper-methylation of the 5' CpG island in human gastric carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11397667&form=6&db=m Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408945&form=6&db=m Cyclooxygenase-2 expression in normal ovaries and epithelial ovarian neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11439356&form=6&db=m Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448905&form=6&db=m Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11469677&form=6&db=m Cyclooxygenase-2: a novel target for cancer chemotherapy? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11495083&form=6&db=m Enhanced cyclooxygenase-2 expression in sporadic and familial adenomatous polyposis of the human colon. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11506952&form=6&db=m Expression of cyclooxygenase-2 (COX-2) mRNA in human colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11518681&form=6&db=m Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11521977&form=6&db=m Cyclooxygenase-2 in carcinogenesis of the gastrointestinal tract. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11555578&form=6&db=m Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566484&form=6&db=m Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11580300&form=6&db=m Clinical potential of cyclo-oxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584358&form=6&db=m Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11602656&form=6&db=m Functional characterization of cyclooxygenase-2 polymorphisms. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605016&form=6&db=m Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605058&form=6&db=m Cyclooxygenase-2 level and culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11606502&form=6&db=m Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11606854&form=6&db=m Interaction between cyclooxygenase-2 and inducible nitric oxide synthase in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11677654&form=6&db=m Cyclooxygenase-2 (COX-2) enzyme inhibitors as potential enhancers of tumor radioresponse. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11694654&form=6&db=m Diet and cancer prevention studies in p53-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11701743&form=6&db=m Increased expression of cyclooxygenase-2 in malignant pheochromocytomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729113&form=6&db=m Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729118&form=6&db=m Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729471&form=6&db=m [COX-2 inhibitor and colon cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11731423&form=6&db=m Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745453&form=6&db=m Is COX-2 inhibition a panacea for cancer prevention? causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751373&form=6&db=m Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751489&form=6&db=m Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11764529&form=6&db=m Role of cyclooxygenase inhibitors for the prevention of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11764539&form=6&db=m Prostaglandin inhibitors and the chemoprevention of noncolonic malignancy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11769881&form=6&db=m An introduction to aspirin, NSAIDs, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis: part I. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11769882&form=6&db=m An introduction to aspirin, NSAids, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis: part II. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779161&form=6&db=m Prostaglandin E(2) stimulates prostatic intraepithelial neoplasia cell growth through activation of the interleukin-6/GP130/STAT-3 signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782353&form=6&db=m Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782374&form=6&db=m Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11793368&form=6&db=m Cyclooxygenase-2 expression during carcinogenesis in the human stomach. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11795429&form=6&db=m Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11798601&form=6&db=m [Study on the effect of COX-2's selective inhibitor on human colorectal adenoma cells proliferation] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809691&form=6&db=m Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11810043&form=6&db=m Expression of cyclooxygenase-2 is associated with carcinogenesis of the lower part of thoracic esophageal squamous cell carcinoma and p53 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821953&form=6&db=m Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11823979&form=6&db=m Overexpression of cyclo-oxygenase 2 in squamous cell carcinoma of the hypopharynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11825662&form=6&db=m Suppression of promoter-dependent transcriptional activity of inducible nitric oxide synthase by sodium butyrate in colon cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827414&form=6&db=m Expression of cyclooxygenase-1 and -2 in urinary bladder carcinomas in vivo and in vitro and prostaglandin E2 synthesis in cultured bladder cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830510&form=6&db=m Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836568&form=6&db=m Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11848504&form=6&db=m Dose-response effects of the COX-2 inhibitor, celecoxib, on the chemoprevention of mammary carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857443&form=6&db=m Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11889377&form=6&db=m Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891209&form=6&db=m Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11895855&form=6&db=m Quantitative trait locus mapping of susceptibilities to butylated hydroxytoluene-induced lung tumor promotion and pulmonary inflammation in CXB mice. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11901304&form=6&db=m COX-2 inhibitors in cancer treatment and prevention, a recent development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11910351&form=6&db=m Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11910360&form=6&db=m Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912139&form=6&db=m Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11917224&form=6&db=m Expression of COX-2, Ki-67, cyclin D1, and P21 in endometrial endometrioid carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920472&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and nonsmall cell lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11931531&form=6&db=m Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11939728&form=6&db=m Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943946&form=6&db=m Cyclooxygenase-2 expression is increased in early intestinal-type gastric cancer and gastric mucosa with intestinal metaplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11945149&form=6&db=m COX selectivity and animal models for colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11952155&form=6&db=m Differential modulation of transforming growth factor-betas and cyclooxygenases in the platelet lysates of male F344 rats by dietary lipids and piroxicam. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11965228&form=6&db=m Celecoxib: a specific COX-2 inhibitor with anticancer properties. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966530&form=6&db=m Review article: COX-2, prostanoids and colon cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966873&form=6&db=m Effect of Helicobacter pylori-induced cyclooxygenase-2 on gastric epithelial cell kinetics: implication for gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11980643&form=6&db=m Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11989839&form=6&db=m Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11993714&form=6&db=m Antidepressants, eicosanoids and the prevention and treatment of cancer. A review. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12003384&form=6&db=m Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009392&form=6&db=m Effects of prostaglandin E(2) on proliferation and apoptosis of epithelial ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12010890&form=6&db=m A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011987&form=6&db=m Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma (Review). causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12022979&form=6&db=m Induction of cyclooxygenase-2 and invasiveness by transforming growth factor-beta(1) in immortalized mouse colonocytes expressing oncogenic Ras. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12024111&form=6&db=m Rationale and feasibility of chemoprovention of hepatocellular carcinoma by cyclooxygenase-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12046075&form=6&db=m Effect of nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12051953&form=6&db=m Characterization of cyclooxygenase-2 (COX-2) during tumorigenesis in human epithelial cancers: evidence for potential clinical utility of COX-2 inhibitors in epithelial cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060668&form=6&db=m Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12064327&form=6&db=m N-3 fatty acids and lipid peroxidation in breast cancer inhibition. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066194&form=6&db=m Chemoprevention of lung cancer by non-steroidal anti-inflammatory drugs among cigarette smokers. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066205&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12067981&form=6&db=m Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086401&form=6&db=m COX-2 and prostanoid receptors: good targets for chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086402&form=6&db=m Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086403&form=6&db=m In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086404&form=6&db=m Increased expression of COX-2 in the development of human lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086405&form=6&db=m Is cyclooxygenase-2 important in skin carcinogenesis? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102578&form=6&db=m Potential role of selective COX-2 inhibitors in cancer management. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102579&form=6&db=m Current application of selective COX-2 inhibitors in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12104042&form=6&db=m Cyclooxygenase-2 inhibitor celecoxib inhibits promotion of mammary tumorigenesis in rats fed a high fat diet rich in n-6 polyunsaturated fatty acids. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110643&form=6&db=m Cyclooxygenase-2 overexpression in colorectal cancer is associated with non-polypoid growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111204&form=6&db=m Cyclooxygenase-2 and Bcl-2 expression in the stomach mucosa of Wistar rats exposed to Helicobacter pylori, N'-methyl- N'-nitro- N-nitrosoguanidine and bile. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115513&form=6&db=m NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126145&form=6&db=m Cyclooxygenase-2 expression in spontaneous intestinal neoplasia of domestic dogs. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126310&form=6&db=m Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12127122&form=6&db=m Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12145422&form=6&db=m Chemoprevention in colorectal neoplasias: what is practical and feasible? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12148579&form=6&db=m Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane. ongoing research,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12154043&form=6&db=m Piroxicam is an ineffective inhibitor of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164941&form=6&db=m Ketoconazole suppresses prostaglandin E(2)-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12168930&form=6&db=m COX-2 expression in rectal carcinoma: immunohistochemical pattern and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173384&form=6&db=m Expression of cyclooxygenase-2 in primary and remnant gastric carcinoma: comparing it with p53 accumulation, Helicobacter pylori infection, and vascular endothelial growth factor expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12174888&form=6&db=m Increased cyclooxygenase-2 expression in human squamous cell carcinomas of the head and neck and inhibition of proliferation by nonsteroidal anti-inflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12189188&form=6&db=m Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12199620&form=6&db=m Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12201625&form=6&db=m The mRNA expression of cyclo-oxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203806&form=6&db=m Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12208745&form=6&db=m Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12221288&form=6&db=m Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12223062&form=6&db=m COX-2 - a target for preventing hepatic carcinoma? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369871&form=6&db=m Selective cyclooxygenase-2 inhibitors and non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12370807&form=6&db=m Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12382025&form=6&db=m Nimesulide and melatonin in mammary carcinogenesis prevention in female Sprague-Dawley rats. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384795&form=6&db=m The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12386924&form=6&db=m Cyclooxygenase-2 promotes prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12394429&form=6&db=m Analysis of cyclooxygenase expression in human colorectal adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12408753&form=6&db=m Expression of inflammation related enzymes during experimental rat lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421501&form=6&db=m [Antisense inhibition of cyclooxygenase-2 reduces malignant phenotype of gastric cancer cells] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12422055&form=6&db=m The future of targeted therapy: combining novel agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429978&form=6&db=m Inhibitory effects of epigallocatechin-3-gallate on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432918&form=6&db=m Cyclooxygenases and colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12433932&form=6&db=m NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434411&form=6&db=m Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434412&form=6&db=m Interstitial cell cyclooxygenase-2 expression is associated with increased angiogenesis in human sporadic colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12447099&form=6&db=m COX-2 inhibitors and their role in gynecology. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452059&form=6&db=m [A study on cyclooxygenase-2 protein expression and vasculature during experimental rat lung carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12457435&form=6&db=m Cyclooxygenase 2 selective inhibitors in cancer treatment and prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460897&form=6&db=m Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12472107&form=6&db=m Role of cyclooxygenase-2 in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12480928&form=6&db=m Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12485462&form=6&db=m Chemopreventive effect of celecoxib and expression of cyclooxygenase-1 and cyclooxygenase-2 on chemically-induced rat mammary tumours. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12491803&form=6&db=m [COX inhibitor, suppression of polyposis, and chemoprevention] causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12494894&form=6&db=m COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499088&form=6&db=m Epidermal growth factor receptors and cyclooxygenase-2 in the pathogenesis of non-small cell lung cancer: potential targets for chemoprevention and systemic therapy. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504031&form=6&db=m High cyclooxygenase-2 expression is related with distant metastasis in cervical cancer treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507282&form=6&db=m A COX-2 inhibitor, nimesulide, inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and iNOS expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523457&form=6&db=m Selective cyclooxygenase-2 inhibition: a target in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12526218&form=6&db=m [Expression of cyclooxygenase-2 in human transitional cell bladder carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12528989&form=6&db=m Cancer chemoprevention drug targets. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12542979&form=6&db=m Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible? causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12543811&form=6&db=m Cyclooxygenase-2 expression and prostanoid biogenesis reflect clinical phenotype in human colorectal fibroblast strains. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559775&form=6&db=m Cyclooxygenase 2: a molecular target for cancer prevention and treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12560924&form=6&db=m Increased cyclooxygenase-2 expression in large flat colorectal tumors (laterally spreading tumors). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12566320&form=6&db=m Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12569549&form=6&db=m A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12575899&form=6&db=m Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12584182&form=6&db=m Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591965&form=6&db=m COX-2, inflammatory secreted PLA2, and cytoplasmic PLA2 protein expression in small bowel adenocarcinomas compared with colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12592098&form=6&db=m Cyclooxygenase-2 expression is associated with well-differentiated and intestinal-type pathways in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606945&form=6&db=m Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12614262&form=6&db=m Overexpression of cyclooxygenase-2 in high-grade human transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12618325&form=6&db=m Cyclooxygenase-2 and prostate carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622426&form=6&db=m Expression of cyclooxygenase-2 protein in colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626523&form=6&db=m Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628507&form=6&db=m Chemoprevention of colon cancer by Korean food plant components. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12636104&form=6&db=m An immunohistochemical study of cyclooxygenase (COX)-2 expression in endocrine tumors of the pancreas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637762&form=6&db=m Cyclooxygenase-2 expression in canine mammary tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12645788&form=6&db=m Gene expression of ornithine decarboxylase, cyclooxygenase-2, and gastrin in atrophic gastric mucosa infected with Helicobacter pylori before and after eradication therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664612&form=6&db=m Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, against PhIP-induced mammary carcinogenesis. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12667327&form=6&db=m [Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12671717&form=6&db=m Do altering in ornithine decarboxylase activity and gene expression contribute to antiproliferative properties of COX inhibitors? causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12677571&form=6&db=m Cyclooxygenase-2 expression in the gallbladder of patients with anomalous arrangement of the pancreaticobiliary duct. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684668&form=6&db=m Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686777&form=6&db=m Expression of COX-2 in stomach cancers and its relation to their biological features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12698187&form=6&db=m Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12702555&form=6&db=m Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12704185&form=6&db=m The RNA-binding protein HuR regulates the expression of cyclooxygenase-2. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713627&form=6&db=m Cyclooxygenase-2 expression in thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12718655&form=6&db=m Genotype Frequencies of Cyclooxygenease 2 (COX2) Rare Polymorphisms for Japanese with and without Colorectal Cancer. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727790&form=6&db=m Nitric oxide induces cyclooxygenase expression and inhibits cell growth in colon cancer cell lines. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12757841&form=6&db=m Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12778076&form=6&db=m Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782823&form=6&db=m Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794581&form=6&db=m Cyclooxygenase-2 expression in colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795049&form=6&db=m Cyclooxygenase-2 and skin carcinogenesis. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795055&form=6&db=m Therapeutic potential of selective cyclooxygenase-2 inhibitors in the management of tumor angiogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12798395&form=6&db=m Carcinogenesis and cyclooxygenase: the potential role of COX-2 inhibition in upper aerodigestive tract cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12800601&form=6&db=m Improvement of radiotherapy or chemoradiotherapy by targeting COX-2 enzyme. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12802790&form=6&db=m Cyclooxygenase-2 inhibitors in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811205&form=6&db=m Cyclooxygenase-2 overexpression correlates with vascular endothelial growth factor expression and tumor angiogenesis in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12814542&form=6&db=m Role of COX-2 specific inhibitors in oncogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824517&form=6&db=m Cyclooxygenase-1 and -2 expression in urothelial carcinomas of the urinary bladder in cows. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824906&form=6&db=m Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor gamma ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839690&form=6&db=m [Relation between COX-2 protein expression and biologic behavior of ovarian carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12844482&form=6&db=m Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12845964&form=6&db=m Cyclooxygenase-2 expression correlates with nuclear p53 accumulation in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12857884&form=6&db=m ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12867070&form=6&db=m Targeted therapies for stage III non-small cell lung cancer: integration in the combined modality setting. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871081&form=6&db=m New targets for the modulation of radiation response--selective inhibition of the enzyme cyclooxygenase 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12873979&form=6&db=m Association between Cyclooxygenase expression and colorectal adenoma characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883469&form=6&db=m H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPAR gamma and impaired apoptosis in gastric carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883661&form=6&db=m Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883688&form=6&db=m Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12885872&form=6&db=m Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12886870&form=6&db=m Irinotecan, cisplatin/carboplatin, and COX-2 inhibition in small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12894507&form=6&db=m The effect of cyclooxygenase inhibitor diclofenac on experimental murine colon carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895350&form=6&db=m [Expression of the cyclooxygenase-2 gene in human breast carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12901877&form=6&db=m PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902859&form=6&db=m Cyclooxygenase-2 (COX-2) enzyme inhibitors and radiotherapy: preclinical basis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12916278&form=6&db=m [Erb-2 overexpression in breast cancer] causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926055&form=6&db=m Expression of cyclooxygenase-2 in malignant and benign breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957358&form=6&db=m Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12969226&form=6&db=m Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12969784&form=6&db=m Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide. therapeutic application,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970750&form=6&db=m Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970891&form=6&db=m Role of COX-2 in carcinogenesis of colorectal cancer and its relationship with tumor biological characteristics and patients' prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500348&form=6&db=m Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500353&form=6&db=m Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14506383&form=6&db=m Cyclo-oxygenase inhibition in colorectal adenomas and cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529404&form=6&db=m COX-2 and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530048&form=6&db=m Lung cancer and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534681&form=6&db=m Carcinogenetic process in gallbladder mucosa with pancreaticobiliary maljunction (Review). causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14550281&form=6&db=m Aberrant methylation of the specific CpG island portion regulates cyclooxygenase-2 gene expression in human gastric carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552327&form=6&db=m COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552703&form=6&db=m Immune restoration in head and neck cancer patients via cyclooxygenase inhibition: an update. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14558947&form=6&db=m [Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566822&form=6&db=m The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14574946&form=6&db=m [Combination therapies using cyclooxygenase-2 inhibitors and angiotensin-converting enzyme inhibitors in colon carcinogenesis] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14582702&form=6&db=m Expression of cyclooxygenase-2 in human hyperplastic gastric polyps. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587862&form=6&db=m COX-2 inhibitors for the prevention of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594546&form=6&db=m Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607721&form=6&db=m Expression of cyclooxygenase-1 and -2 in extra-hepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14608118&form=6&db=m Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14609132&form=6&db=m Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose in murine macrophage cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14616542&form=6&db=m Cyclooxygenase-2 and gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623934&form=6&db=m Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14625126&form=6&db=m Cyclooxygenase-2 expression in the endometrium at the end of 2 years' continuous combined hormone replacement therapy. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14626203&form=6&db=m Differential expression pattern of cyclooxygenase-1 and -2 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14627349&form=6&db=m Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14629099&form=6&db=m Barrett's esophagus: chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633677&form=6&db=m Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14640580&form=6&db=m Methanolic extract of adlay seed suppresses COX-2 expression of human lung cancer cells via inhibition of gene transcription. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14640918&form=6&db=m Cyclooxygenase inhibition in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14642098&form=6&db=m [The clinical significance of expression of cyclooxygenase-2 gene in breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14643021&form=6&db=m Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14643442&form=6&db=m Chemoprevention of mammary carcinogenesis in female rats by rofecoxib. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14649330&form=6&db=m Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and reality. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14675489&form=6&db=m Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678698&form=6&db=m [Role of cyclooxygenase-2 in the pathogenesis of chronic liver diseases] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14701858&form=6&db=m Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14707443&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in human esophageal mucosa, dysplasia and carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14712483&form=6&db=m Significance of COX-2 expression in human renal cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14713750&form=6&db=m Inflammation as a target for prostate cancer chemoprevention: pathological and laboratory rationale. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717230&form=6&db=m Immunohistochemical expression of COX-2 in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717665&form=6&db=m Cyclooxygenase-2 expression: a potential prognostic and predictive marker for high-grade ductal carcinoma in situ of the breast. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719060&form=6&db=m COX-2 status in relation to tumor microvessel density and VEGF expression: analysis in ovarian carcinoma patients with low versus high survival rates. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14724149&form=6&db=m Chemoprevention of gastric cancer by celecoxib in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729583&form=6&db=m Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734479&form=6&db=m Celecoxib but not rofecoxib inhibits the growth of transformed cells in vitro. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14742316&form=6&db=m Carcinogenic properties of proteins with pro-inflammatory activity from Streptococcus infantarius (formerly S.bovis). diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14742435&form=6&db=m Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14743889&form=6&db=m Role of cyclooxygenase-2 in the development and treatment of oesophageal adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14758024&form=6&db=m Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760075&form=6&db=m Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766245&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in non-neoplastic and neoplastic vulvar epithelial lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766253&form=6&db=m Cyclooxygenase-2 expression predicts recurrence of cervical dysplasia following loop electrosurgical excision procedure. ongoing research,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14769841&form=6&db=m Cyclooxygenase-2 expression and its relationship with proliferation of colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871855&form=6&db=m Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871987&form=6&db=m Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14962510&form=6&db=m A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14965326&form=6&db=m Dysregulated post-transcriptional control of COX-2 gene expression in cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14972014&form=6&db=m Pro/antioxidant status in murine skin following topical exposure to cumene hydroperoxide throughout the ontogeny of skin cancer. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14977638&form=6&db=m Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14989896&form=6&db=m [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991580&form=6&db=m Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991895&form=6&db=m Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996749&form=6&db=m Cyclooxygenase-2-dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14998726&form=6&db=m Involvement of ERK AND p38 MAP kinase in AAPH-induced COX-2 expression in HaCaT cells. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999366&form=6&db=m Cyclooxygenase-2 inhibitors in glioma therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999691&form=6&db=m Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15000150&form=6&db=m Role of cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15013430&form=6&db=m Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014433&form=6&db=m Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020200&form=6&db=m Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15027493&form=6&db=m Cyclooxygenase 2: from inflammation to carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15035887&form=6&db=m Inflammation as cause for scar cancers of the lung. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15040874&form=6&db=m The role of cyclooxygenase-2 inhibition for the prevention and treatment of prostate carcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15049901&form=6&db=m Cyclooxygenase-2 expression and relationship to tumour progression in human renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15052544&form=6&db=m Cyclooxygenase-2: a potential target in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15055524&form=6&db=m The correlation between cyclooxygenase-2 expression and hepatocellular carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15056798&form=6&db=m Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15063780&form=6&db=m Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15064999&form=6&db=m Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067366&form=6&db=m The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069535&form=6&db=m Inhibitory effects of etodolac, a selective COX-2 inhibitor, on the occurrence of tumors in colitis-induced tumorigenesis model in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075004&form=6&db=m Expression of cyclooxygenase-1 and -2 and clinicopathologic features of colorectal cancer in northern Thailand. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15088099&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102519&form=6&db=m Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102586&form=6&db=m COX-2 inhibition in cancer therapeutics: a field of controversy or a magic bullet? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15112579&form=6&db=m Nuclear factor-kappa B regulates cyclooxygenase-2 expression and cell proliferation in human colorectal carcinoma tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15117812&form=6&db=m Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15122305&form=6&db=m Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15126378&form=6&db=m Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15136465&form=6&db=m Cyclooxygenase-2 in lung carcinogenesis and chemoprevention: Roger S. Mitchell lecture. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15139997&form=6&db=m Expression of COX-2 is increased with age in papillary thyroid cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15142670&form=6&db=m Modulatory influence of garlic and tomato on cyclooxygenase-2 activity, cell proliferation and apoptosis during azoxymethane induced colon carcinogenesis in rat. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15144801&form=6&db=m Expression of cyclooxygenase-1 and -2 in canine nasal carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145696&form=6&db=m Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151617&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15155531&form=6&db=m Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrest. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15156115&form=6&db=m [Role of cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor (PPAR) in gastric cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162003&form=6&db=m Cyclo-oxygenase 2 expression in laryngeal squamous cell carcinoma and its clinical correlates. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15163022&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in colorectal carcinoma assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15163555&form=6&db=m Induction of cyclooxygenase-2 by bovine type I collagen in macrophages via C/EBP and CREB activation by multiple cell signaling pathways. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15165031&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172119&form=6&db=m Effect of LY293111 in combination with gemcitabine in colonic cancer. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15175041&form=6&db=m Treatment with 5-fluorouracil and celecoxib displays synergistic regression of ultraviolet light B-induced skin tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15182426&form=6&db=m Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15199544&form=6&db=m Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15207385&form=6&db=m Effects of adlay on azoxymethane-induced colon carcinogenesis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217968&form=6&db=m Molecularly targeted approaches to the chemoprevention of lung cancer. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218294&form=6&db=m Cyclooxygenase-2 expression in chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15220752&form=6&db=m Chemoprevention of lung cancer. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15224350&form=6&db=m Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15225655&form=6&db=m Suppressive effects of the kahweol and cafestol on cyclooxygenase-2 expression in macrophages. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15234907&form=6&db=m Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15238218&form=6&db=m Essential role of c-Jun induction and coactivator p300 in epidermal growth factor-induced gene expression of cyclooxygenase-2 in human epidermoid carcinoma A431 cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239333&form=6&db=m [Cyclooxygenase 2 and carcinogenesis] causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239337&form=6&db=m [Cyclooxygenase 2 and breast cancer. From biological concepts to therapeutic trials] causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239338&form=6&db=m [Cyclooxygenase 2 inhibitors and lung carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15246187&form=6&db=m Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15250241&form=6&db=m Effects of cyclooxygenase-2 antisense vector on proliferation of human cholangiocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256475&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265936&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15266135&form=6&db=m [Role of COX-2 and PPAR in gastric carcinogenesis] ongoing research,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15266333&form=6&db=m Clinical implication of expression of cyclooxygenase-2 and peroxisome proliferator activated-receptor gamma in epithelial ovarian tumours. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15269153&form=6&db=m Gastrin-induced cyclooxygenase-2 expression in Barrett's carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15274307&form=6&db=m Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; correlation with intratumoral microvessel density and apoptotic index. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15279596&form=6&db=m COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15283156&form=6&db=m [Overexpression of COX-2 and a potential clinical application of its inhibitors in lung cancer] causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15285012&form=6&db=m COX-2 expression and tumor angiogenesis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15287038&form=6&db=m Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15292928&form=6&db=m Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15297372&form=6&db=m Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15299086&form=6&db=m Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer? causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313405&form=6&db=m Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313935&form=6&db=m Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319438&form=6&db=m Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332534&form=6&db=m [COX and study of cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15334675&form=6&db=m Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15342458&form=6&db=m Cyclooxygenase-2 and p53 expressions in endometrial cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15353307&form=6&db=m Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355919&form=6&db=m Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15373703&form=6&db=m Inhibition of azoxymethane-induced colon carcinogenesis in rats due to JTE-522, a selective cyclooxygenase-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385109&form=6&db=m Cyclooxygenase-2 expression in borderline ovarian tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386426&form=6&db=m Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15387324&form=6&db=m Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15455344&form=6&db=m JTE-522, a selective cyclooxygenase-2 inhibitor, inhibits induction but not growth and invasion of 1,2-dimethylhydrazine-induced tubular adenocarcinomas of colon in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456896&form=6&db=m Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src-dependent nuclear factor-kappaB activation. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15459875&form=6&db=m [Cyclooxygenase-2-expression in bladder cancer: tumor-biological and clinical implications] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15470535&form=6&db=m Barrett's Esophagus. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15472909&form=6&db=m Selective inhibition of cyclooxygenase (COX)-2 inhibits endothelial cell proliferation by induction of cell cycle arrest. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15482327&form=6&db=m Nimesulide and indomethacin induce apoptosis in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15482328&form=6&db=m Increased expression of cyclooxygenase (COX)-2 in DMBA-induced hamster cheek pouch carcinogenesis and chemopreventive effect of a selective COX-2 inhibitor celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15483103&form=6&db=m Distinct regulation of cyclooxygenase-2 by interleukin-1beta in normal and endometriotic stromal cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491425&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498296&form=6&db=m [The significance of the expression of cyclooxygenase-2 in bladder transitional cell carcinoma tissues] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498788&form=6&db=m Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501074&form=6&db=m COX-2 inhibition as a tool to treat and prevent colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501972&form=6&db=m Concomitant overexpression of cyclooxygenase-2 in HER-2-positive on Smad4-reduced human gastric carcinomas is associated with a poor patient outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15505432&form=6&db=m [Cyclooxygenase-2 expression according to size and location of gastric and colorectal tubular adenomas] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523901&form=6&db=m Sequential expression of inducible nitric oxide synthase and cyclooxygenase-2 during DMBA-induced hamster buccal pouch carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15538221&form=6&db=m Impact of cyclooxygenase-2 gene expression on tumor invasiveness in a human renal cell carcinoma cell line. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15564290&form=6&db=m A COX-2 inhibitor prevents the esophageal inflammation-metaplasia-adenocarcinoma sequence in rats. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15577196&form=6&db=m Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585388&form=6&db=m Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585629&form=6&db=m Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585646&form=6&db=m the selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15587390&form=6&db=m Expression and significance of cyclooxygenase 2 gene in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596182&form=6&db=m Significance of COX-2 expression in human renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15608668&form=6&db=m Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15609394&form=6&db=m Different cell kinetic changes in rat stomach cancer after treatment with celecoxib or indomethacin: implications on chemoprevention. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15617991&form=6&db=m Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623626&form=6&db=m Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623844&form=6&db=m beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625783&form=6&db=m Suppressive effects of a selective cyclooxygenase-2 inhibitor, etodolac, on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630167&form=6&db=m Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630188&form=6&db=m Inhibition of phorbol ester-induced COX-2 expression by some edible African plants. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632379&form=6&db=m Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637091&form=6&db=m Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637389&form=6&db=m Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15638270&form=6&db=m Cyclooxygenase-2 expression in canine appendicular osteosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645119&form=6&db=m COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15649252&form=6&db=m Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model: biological impact of capsular inflammation and reduced cyclooxygenase-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15660656&form=6&db=m Cyclooxygenase-2 expression in primary Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681840&form=6&db=m Cystic duct dilatations and proliferative epithelial lesions in mouse mammary glands upon keratin 5 promoter-driven overexpression of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15682318&form=6&db=m Expression and clinical significance of vascular endothelial growth factor, cyclooxygenase-2, and Bcl-2 in borderline ovarian tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683997&form=6&db=m [Effects of combined use of curcumin and catechin on cyclooxygenase-2 mRNA expression in dimethylhydrazine-induced rat colon carcinogenesis] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685827&form=6&db=m Celecoxib and radiation therapy in non-small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15688375&form=6&db=m The evolution of predictive oncology and molecular-based therapy for oral cancer prevention. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15694043&form=6&db=m [Expressions of cyclooxygenase-2 and cholecystokinin-B receptor mRNA in human colorectal cancer and their significances] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695237&form=6&db=m Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701502&form=6&db=m Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15703837&form=6&db=m A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-kappaB, and steroid hormone receptors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15713675&form=6&db=m Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15731164&form=6&db=m Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by raloxifene, an antiestrogen with anti-androgen action, but not nimesulide, a selective cyclooxygenase-2 inhibitor. therapeutic application,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15736413&form=6&db=m Effect of cyclooxygenase-2 antisense oligodeoxyribonucleotides in A-549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15741988&form=6&db=m Modulation of COX-2 expression in peripheral blood cells by increased intake of fruit and vegetables? causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743541&form=6&db=m JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743693&form=6&db=m Cyclo-oxygenase-1 and -2 expression in human oral mucosa, dysplasias and squamous cell carcinomas and their pathological significance. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753376&form=6&db=m p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754118&form=6&db=m Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756026&form=6&db=m Celecoxib inhibits prostate cancer growth: evidence of a cyclooxygenase-2-independent mechanism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756036&form=6&db=m Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756426&form=6&db=m Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15772294&form=6&db=m Activating protein 1-mediated cyclooxygenase-2 expression is independent of N-terminal phosphorylation of c-Jun. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15777967&form=6&db=m A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15790444&form=6&db=m The expression of cyclooxygenase-2, VEGF and PGs in CIN and cervical carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15797624&form=6&db=m Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15800927&form=6&db=m E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15805430&form=6&db=m Cancer prevention: a new era beyond cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816645&form=6&db=m Differential cyclooxygenase-2 enzyme expression in radiosensitive versus radioresistant glioblastoma multiforme cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817909&form=6&db=m High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15837998&form=6&db=m COX-2: a molecular target for colorectal cancer prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15841716&form=6&db=m Rofecoxib does not inhibit aberrant crypt foci formation but inhibits later steps in the development of experimental colorectal cancer: rofecoxib in experimental colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15846217&form=6&db=m Correlation of cyclooxygenase-2 (COX-2) and aromatase expression in human endometrial cancer: tissue microarray analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856465&form=6&db=m Cyclooxygenase-2 overexpression in MCF-10F human breast epithelial cells inhibits proliferation, apoptosis and differentiation, and causes partial transformation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15858127&form=6&db=m Cyclooxygenase 2 expression in nasopharyngeal carcinoma: immunohistochemical findings and potential implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863127&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863148&form=6&db=m Estrogen and progesterone receptors and cyclooxygenase-2 expression in endometrial cancer, endometrial hyperplasia, and normal endometrium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878914&form=6&db=m The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880952&form=6&db=m Cyclooxygenase-2 regulates the degree of apoptosis by modulating bcl-2 protein in pleomorphic adenoma and mucoepidermoid carcinoma of the parotid gland. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15886845&form=6&db=m [The expressions of cyclooxygenase-2 (Cox-2),VEGF in oral squamous cell carcinoma and precancerous lesions and their significances] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15892674&form=6&db=m The role of COX-2 in oral cancer development, and chemoprevention/ treatment of oral cancer by selective COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15892897&form=6&db=m Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899629&form=6&db=m [Cyclooxygenase 2 and carcinogenesis] causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899633&form=6&db=m [Cyclooxygenase 2 and breast cancer. From biological concepts to clinical trials] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899634&form=6&db=m [Cyclooxygenase 2 inhibitors and lung carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15907789&form=6&db=m Resistance of prostate cancer cell lines to COX-2 inhibitor treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15931767&form=6&db=m Oxidative stress mediated idiosyncratic drug toxicity. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15938900&form=6&db=m [COX-2 inhibitors: a novel way to prevent and treat the carcinogenesis of oral mucosa] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944215&form=6&db=m Inhibitory effect of meloxicam, a cyclooxygenase-2 inhibitor, on N-nitrosobis (2-oxopropyl) amine induced biliary carcinogenesis in Syrian hamsters. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15949425&form=6&db=m [COX-2 expression in the H. pylori infected gastric mucosal epithelia and its significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15958546&form=6&db=m Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15965085&form=6&db=m Inhibitory Effects of a Rice Hull Constituent on Tumor Necrosis Factor {alpha}, Prostaglandin E2, and Cyclooxygenase-2 Production in Lipopolysaccharide-Activated Mouse Macrophages. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15967164&form=6&db=m COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15978332&form=6&db=m Prognostic role of cyclooxygenase-2 expression in esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15980665&form=6&db=m Cyclooxygenase-2 expression associated with severity of PanIN lesions: a possible link between chronic pancreatitis and pancreatic cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15991524&form=6&db=m Expression of cyclooxygenase-2 in endometrial adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000571&form=6&db=m Cyclooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16002278&form=6&db=m Cyclooxygenase-2: how good is it as a target for cancer chemoprevention? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16009342&form=6&db=m Inhibitory effect of etodolac, a selective cyclooxygenase-2 inhibitor, on stomach carcinogenesis in Helicobacter pylori-infected Mongolian gerbils. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16011415&form=6&db=m Effect of rofecoxib on colon chemical carcinogenesis at colonic anastomotic area in the rat. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16018788&form=6&db=m Non-steroidal anti-inflammatory drugs for the prevention and treatment of cancer. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16024629&form=6&db=m Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16034162&form=6&db=m Inhibition of azoxymethane-induced aberrant crypt foci in rat by diphenylmethyl selenocyanate through downregulation of COX-2 and modulation of glutathione-S-transferase and lipid peroxidation. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16042570&form=6&db=m Prospects in NSAID-derived chemoprevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16044407&form=6&db=m Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054423&form=6&db=m Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054711&form=6&db=m Anisomycin induces COX-2 mRNA expression through p38(MAPK) and CREB independent of small GTPases in intestinal epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055866&form=6&db=m COX-2 expression during early lung squamous cell carcinoma oncogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081631&form=6&db=m A positive feedback loop that regulates cyclooxygenase-2 expression and prostaglandin F2alpha synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16082585&form=6&db=m Elevated cyclooxygenase-2 expression in patients with early gastric cancer in the gastric pylorus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083916&form=6&db=m Prevention of human cancer by modulation of chronic inflammatory processes. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16085694&form=6&db=m Monocyte chemoattractant protein 1 and macrophage cyclooxygenase 2 expression in colonic adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16097073&form=6&db=m Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16098242&form=6&db=m Chemoprevention strategies with cyclooxygenase-2 inhibitors for lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16110762&form=6&db=m Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113051&form=6&db=m Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16119982&form=6&db=m Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136511&form=6&db=m COX-2 overexpression in canine tumors: potential therapeutic targets in oncology. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136748&form=6&db=m Cyclooxygenase-2 in sporadic colorectal polyps: immunohistochemical study and its importance in the early stages of colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140976&form=6&db=m Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16157291&form=6&db=m Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16158946&form=6&db=m Cyclooxygenase-2 expression is associated with increased size in human sporadic colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16169726&form=6&db=m Expression of cyclooxygenase-2 in breast carcinogenesis and its relation to HER-2/neu and p53 protein expression in invasive ductal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170019&form=6&db=m The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice. ongoing research,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170038&form=6&db=m Interaction between epidermal growth factor receptor- and cyclooxygenase 2-mediated pathways and its implications for the chemoprevention of head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170369&form=6&db=m Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16203768&form=6&db=m The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16216410&form=6&db=m Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219637&form=6&db=m Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243808&form=6&db=m Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247189&form=6&db=m Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16255988&form=6&db=m [Roles of cyclooxygenase-2 and caspase-3 expression in pathogenesis of lung carcinoma: an experiment with rats] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16266236&form=6&db=m Cyclooxygenase-2 inhibition in colon experimental carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267038&form=6&db=m HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273249&form=6&db=m Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head and neck cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16279229&form=6&db=m [Cyclooxygenases in the skin] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16317086&form=6&db=m Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16319132&form=6&db=m Sphingosine kinase 1 is up-regulated in colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16326073&form=6&db=m Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16334139&form=6&db=m Cyclooxygenase-2 protein expression in relation to apoptotic potential and its prognostic significance in bladder urothelial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337966&form=6&db=m Bile acid promotes the proliferation of squamous cell carcinoma of the esophagus, independent of its inducing COX-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352617&form=6&db=m Significance of COX-2 expression in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357153&form=6&db=m Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16371352&form=6&db=m Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16386831&form=6&db=m Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391811&form=6&db=m Cyclooxygenase-2 knockdown by RNA interference in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16413115&form=6&db=m 9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16417238&form=6&db=m Importance of the EP(1) receptor in cutaneous UVB-induced inflammation and tumor development. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16418176&form=6&db=m Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). therapeutic application,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424122&form=6&db=m Conjugated Linoleic Acid Attenuates Cyclooxygenase-2 Transcriptional Activity via an Anti-AP-1 Mechanism in MCF-7 Breast Cancer Cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16426736&form=6&db=m Expression of COX-2 in normal and pyelonephritic kidney, renal intraepithelial neoplasia, and renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16438886&form=6&db=m [Expression of cyclooxygenase-2, hMLH1 and hMSH2 proteins, and their relationship with microsatellite instability in gastric carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16446079&form=6&db=m Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16455185&form=6&db=m The importance of cyclooxygenase in carcinogenesis: is it a therapeutic target? causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16469040&form=6&db=m Chemopreventive effects of cyclooxygenase-2 inhibitor and epidermal growth factor-receptor kinase inhibitor on rat urinary bladder carcinogenesis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474375&form=6&db=m Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16481301&form=6&db=m Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489098&form=6&db=m The Cyclooxygenase-2 (PTGS2) 8473T>C Polymorphism is Associated with Breast Cancer Risk. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489533&form=6&db=m COX-2 Polymorphism, Use of Nonsteroidal Anti-Inflammatory Drugs, and Risk of Colon Cancer in African Americans (United States). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16494037&form=6&db=m [The expressiong of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16506214&form=6&db=m Genetic variation in the COX-2 gene and the association with prostate cancer risk. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507400&form=6&db=m The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508969&form=6&db=m Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510608&form=6&db=m Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16521222&form=6&db=m Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16528365&form=6&db=m Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16538539&form=6&db=m COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic molecular markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550596&form=6&db=m Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552798&form=6&db=m Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552960&form=6&db=m [Ease-2 and inducible nitric oxide synthase in tongue hyperplasia and tongue squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16557596&form=6&db=m Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrence. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16586533&form=6&db=m Helicobacter pylori eradication to prevent gastric cancer: Underlying molecular and cellular mechanisms. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16615003&form=6&db=m Effects of cyclooxygenase-2 inhibition on serum and tumor gastrins and expression of apoptosis-related proteins in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627221&form=6&db=m Helicobacter pylori extract induces nuclear factor-kappa B, activator protein-1, and cyclooxygenase-2 in esophageal epithelial cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632477&form=6&db=m Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677165&form=6&db=m Influences of Helicobacter pylori on cyclooxygenase-2 expression and prostaglandinE2 synthesis in rat gastric epithelial cells in vitro. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16681724&form=6&db=m Expression of cyclooxygenase-2 and inducible nitric oxide synthase in ovarian surface epithelial carcinomas: is there any correlation with angiogenesis or clinicopathologic parameters? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685147&form=6&db=m Differential protein expression in the epidermis of wild-type and COX-2 transgenic mice. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685273&form=6&db=m Prostaglandin E(2) stimulates progression-related gene expression in early colorectal adenoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685448&form=6&db=m Differential targeting of protein kinase B in cell death induced by sulindac and its metabolite sulindac sulfide. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16688727&form=6&db=m Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699180&form=6&db=m The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712448&form=6&db=m Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: topical therapeutic strategies targeting COX-2 expression and activity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712449&form=6&db=m The potential and rationale for COX-2 inhibitors in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16720359&form=6&db=m Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731743&form=6&db=m RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16733888&form=6&db=m [Genetic polymorphisms in the promoter region of cyclooxygenase-2 and their association with risk of gastric cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16750016&form=6&db=m [Expression and significance of interleukin-8 cyclooxygenase-2 and trefoil family factor 1 in the remnant stomach mucosa] unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16752205&form=6&db=m Cyclooxygenase-2 expression correlates with membrane-type-1 matrix metalloproteinase expression in colorectal cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16757341&form=6&db=m Ras up-regulation of cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16757698&form=6&db=m Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16786154&form=6&db=m COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16810500&form=6&db=m Lysophosphatidylcholine suppresses apoptotic cell death by inducing cyclooxygenase-2 expression via a Raf-1 dependent mechanism in human cholangiocytes. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818639&form=6&db=m Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818642&form=6&db=m Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16819278&form=6&db=m Heterogeneous nuclear ribonuclear protein C is increased in the celecoxib-induced growth inhibition of human oral squamous cell carcinoma. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820089&form=6&db=m Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16822500&form=6&db=m NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835502&form=6&db=m Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16842185&form=6&db=m Roles of prostanoids in colon carcinogenesis and their potential targeting for cancer chemoprevention. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849589&form=6&db=m Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16859832&form=6&db=m Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16863510&form=6&db=m Chemoprevention of spontaneous development of hepatocellular carcinomas in fatty liver Shionogi mice by a cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16870006&form=6&db=m Soya isoflavones suppress phorbol 12-myristate 13-acetate-induced COX-2 expression in MCF-7 cells. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16886613&form=6&db=m Preventive effect of ortho dimer of butylated hydroxyanisole on activator protein-1 activation and cyclooxygenase-2 expression in macrophages stimulated by fimbriae of Porphyromonas gingivalis, an oral anaerobe. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899628&form=6&db=m Effects of long-term rofecoxib on gastric intestinal metaplasia: results of a randomized controlled trial. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900533&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16916756&form=6&db=m More than structural cells, fibroblasts create and orchestrate the tumor microenvironment. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16921484&form=6&db=m What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis? causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16921490&form=6&db=m Benzo[a]pyrene diol-epoxide (B[a]PDE) upregulates COX-2 expression through MAPKs/AP-1 and IKKbeta/NF-kappaB in mouse epidermal Cl41 cells. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16925606&form=6&db=m Pathogenesis of Helicobacter pylori Infection. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16928824&form=6&db=m Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16937518&form=6&db=m Cyclooxygenases in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949556&form=6&db=m Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16950795&form=6&db=m cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16952200&form=6&db=m Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16963204&form=6&db=m Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966442&form=6&db=m Cyclooxygenase-2 expression in normal and neoplastic canine mammary cell lines. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966444&form=6&db=m Transitional Cell Carcinoma in Fishing Cats (Prionailurus viverrinus): Pathology and Expression of Cyclooxygenase-1, -2, and p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16981245&form=6&db=m C/EBPbeta is over-expressed in gastric carcinogenesis and is associated with COX-2 expression. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984258&form=6&db=m Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E production. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984374&form=6&db=m Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16995982&form=6&db=m [A relationship between cyclooxygenase-2 expression and tumor angiogenesis in experimental rat liver carcinogenesis.] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996907&form=6&db=m Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16999939&form=6&db=m Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17011176&form=6&db=m Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17018624&form=6&db=m Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17023910&form=6&db=m The molecular basis of colorectal carcinogenesis. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030179&form=6&db=m Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17031478&form=6&db=m DNA repair Ku proteins in gastric cancer cells and pancreatic acinar cells. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17038629&form=6&db=m Azoxymethane protects intestinal stem cells and reduces crypt epithelial mitosis through a COX-1-dependent mechanism. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17040897&form=6&db=m Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17052996&form=6&db=m A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17064999&form=6&db=m Expression of cyclooxygenase-2 in Hodgkin's lymphoma: its role in cell proliferation and angiogenesis. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17073683&form=6&db=m Imaging of cyclooxygenase-2 (COX-2) expression: potential use in diagnosis and drug evaluation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17074019&form=6&db=m Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17074152&form=6&db=m [Expression of tissue microarray p53, p16 and cyclooxygenase-2 in gastric cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17074806&form=6&db=m Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17093206&form=6&db=m Mitogenic signal transduction caused by monomethylarsonous acid in human bladder cells: role in arsenic-induced carcinogenesis. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17100567&form=6&db=m Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17118848&form=6&db=m Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17126249&form=6&db=m The status of cyclooxygenase-2 expression in ductal carcinoma in situ lesions and invasive breast cancer correlates to cyclooxygenase-2 expression in normal breast tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130837&form=6&db=m Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17147116&form=6&db=m [Flow cytometric quantitative analysis of multiple tumor suppressor gene 1 (MTS1) and cyclooxygenase-2 (COX-2) gene expressions in invasive breast cancers and their clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151091&form=6&db=m Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17166374&form=6&db=m [Inhibitory effects of Aspisol on growth of transplanted breast cancer in C3H mice] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17177652&form=6&db=m Cyclooxygenase-2 expression determines neo-angiogenesis in gallbladder carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178380&form=6&db=m Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17183061&form=6&db=m Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17187167&form=6&db=m Bile duct cyst as precursor to biliary tract cancer. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17190766&form=6&db=m Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis. ongoing research,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17202703&form=6&db=m Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17203971&form=6&db=m Protein expression profiles in the epidermis of cyclooxygenase-2 transgenic mice by 2-dimensional gel electrophoresis and mass spectrometry. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17219415&form=6&db=m Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234720&form=6&db=m Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234795&form=6&db=m Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17249380&form=6&db=m Cyclooxygenase-2 and tumor biology. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17264535&form=6&db=m Coordinated upregulation of COX-2 and NF-kappaB is a steady feature of laryngeal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17269882&form=6&db=m Immunohistochemical evaluation of cyclooxygenase expression in corneal squamous cell carcinoma in horses. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17274057&form=6&db=m Cyclooxygenase-2 expression in medullary thyroid carcinoma. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17295901&form=6&db=m Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17302183&form=6&db=m Tumor promotion as a target of cancer prevention. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17354234&form=6&db=m Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363183&form=6&db=m Antidepressants, prostaglandins and the prevention and treatment of cancer. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363560&form=6&db=m Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17372274&form=6&db=m Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17374970&form=6&db=m Expression of receptor for advanced glycation end products during rat tongue carcinogenesis by 4-nitroquinoline 1-oxide and effect of a selective cyclooxygenase-2 inhibitor, etodolac. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17381414&form=6&db=m Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403587&form=6&db=m p-Phenylenediamine induced DNA damage in SV-40 immortalized human uroepithelial cells and expression of mutant p53 and COX-2 proteins. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404027&form=6&db=m Increased cyclooxygenase-2 expression associated with inflammatory cellular infiltration in elderly patients with vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17415806&form=6&db=m Cyclooxygenase inhibitors in the chemoprevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430655&form=6&db=m [Effects of selective cyclooxygenase-2 inhibitor on proliferation and apoptosis of human bladder cancer cell line T24] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17440114&form=6&db=m Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange. ongoing research,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17443745&form=6&db=m A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17448140&form=6&db=m Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17450217&form=6&db=m Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17460548&form=6&db=m Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17466901&form=6&db=m Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: two steps forward, one step back. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17479405&form=6&db=m Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17479667&form=6&db=m Effects of selective estrogen receptor modulators and genistein on the expression of ERalpha/beta and COX-1/2 in ovarectomized mouse uteri. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483309&form=6&db=m The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504375&form=6&db=m Cell proliferation activity unrelated to COX-2 expression in ovarian tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17515883&form=6&db=m Cyclooxygenase 2 expression in pterygium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17523957&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17535415&form=6&db=m Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17542993&form=6&db=m COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17549353&form=6&db=m Overexpression of cysteinyl LT1 receptor in prostate cancer and CysLT1R antagonist inhibits prostate cancer cell growth through apoptosis. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17552358&form=6&db=m Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17559081&form=6&db=m Ang II and EGF synergistically induce COX-2 expression via CREB in intestinal epithelial cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17578436&form=6&db=m Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17582597&form=6&db=m Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17583568&form=6&db=m The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependent. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17591056&form=6&db=m Clinicopathologic significance of expression of cyclooxygenase-2 in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17600311&form=6&db=m EGFR Signaling Is Required for TGF-beta1 Mediated COX-2 Induction in Human Bronchial Epithelial Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17604323&form=6&db=m COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612047&form=6&db=m Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612053&form=6&db=m Strategies for colon cancer prevention: combination of chemopreventive agents. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624243&form=6&db=m Cyclooxygenase isozymes in oral squamous cell carcinoma:a real-time RT-PCR study with clinic pathological correlations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640394&form=6&db=m Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17646715&form=6&db=m Methanol extracts of Stewartia koreana inhibit cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) gene expression by blocking NF-kappaB transactivation in LPS-activated RAW 264.7 cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17650224&form=6&db=m Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17659693&form=6&db=m COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarray. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17664473&form=6&db=m Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non small-cell lung cancer. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671709&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in primary central nervous system lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17672932&form=6&db=m [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17675820&form=6&db=m [Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide] causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17691904&form=6&db=m Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17693664&form=6&db=m Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17716351&form=6&db=m Therapeutic effect of nimesulide on colorectal carcinogenesis in experimental murine ulcerative colitis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17724132&form=6&db=m COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17762961&form=6&db=m 5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17767717&form=6&db=m The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17767925&form=6&db=m Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-kappaB activation and COX-2 expression in human breast epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17826825&form=6&db=m COX-2 overexpression as a biomarker of early cervical carcinogenesis: A pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17851687&form=6&db=m COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875728&form=6&db=m Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17889918&form=6&db=m Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893232&form=6&db=m Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893865&form=6&db=m Targeting NOX, INOS and COX-2 in inflammatory cells: Chemoprevention using food phytochemicals. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17899436&form=6&db=m Cyclooxygenase-2 expression: does it have a probable role in tumorigenesis mechanisms of renal cell carcinoma? diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17906315&form=6&db=m Arsenic salt-induced DNA damage and expression of mutant p53 and COX-2 proteins in SV-40 immortalized human uroepithelial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17906615&form=6&db=m Prostanoid receptor EP1 expression in breast cancer. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908994&form=6&db=m Exisulind in Combination with Celecoxib Modulates Epidermal Growth Factor Receptor, Cyclooxygenase-2, and Cyclin D1 against Prostate Carcinogenesis: In vivo Evidence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17942462&form=6&db=m The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17950089&form=6&db=m Effect of Celecoxib and Novel Agent LC-1 in a Hamster Model of Lung Cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17961044&form=6&db=m Inflammatory response and meningioma tumorigenesis and the effect of cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17961495&form=6&db=m Cyclooxygenase-2 induction requires activation of nuclear factor of activated T-cells in Beas-2B cells after vanadium exposure and plays an anti-apoptotic role. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962194&form=6&db=m Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962218&form=6&db=m Inhibitory effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17985342&form=6&db=m Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996482&form=6&db=m Expression of cyclooxygenase-2 and DNA topoisomerase II alpha in precancerous and cancerous lesions of the oral mucosa. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17999989&form=6&db=m Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055324&form=6&db=m Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055759&form=6&db=m Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094611&form=6&db=m Increased expression of cytoplasmic HuR in familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097584&form=6&db=m Hepatocyte growth factor induces anoikis resistance by up-regulation of cyclooxygenase-2 expression in uterine endometrial cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159171&form=6&db=m [COX-2 inhibitors in inflammatory bowel disease: friends or foes?] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159174&form=6&db=m [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167131&form=6&db=m Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: the Self Defense Forces Health Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174234&form=6&db=m Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18186150&form=6&db=m COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18190720&form=6&db=m Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194346&form=6&db=m Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18197933&form=6&db=m COX-2 mRNA expression in esophageal squamous cell carcinoma (ESCC) and effect by NSAID. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202786&form=6&db=m Inhibitory effects of the cyclooxygenase-2 inhibitor, etodolac, on colitis-associated tumorigenesis in p53-deficient mice treated with dextran sulfate sodium. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18204294&form=6&db=m Correlative expression of cyclooxygenase-1 (cox-1) and human epidermal growth factor receptor type-2 (her-2) in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18228100&form=6&db=m Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230181&form=6&db=m Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18250037&form=6&db=m [Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18256803&form=6&db=m Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18258354&form=6&db=m Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18266822&form=6&db=m Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18311113&form=6&db=m The COX-2 promoter polymorphism -765 G>C is associated with early-onset, conventional and stump gastric cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314623&form=6&db=m [Significance of cyclooxygenase-2 as a chemotherapeutic target in hepatocellular carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18330256&form=6&db=m [Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18348265&form=6&db=m Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18349295&form=6&db=m Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Gene Polymorphisms and Risk of Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18365911&form=6&db=m Altered distribution of beta-catenin and prognostic roles in colorectal carcinogenesis. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381589&form=6&db=m Resveratrol directly targets COX-2 to inhibit carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381950&form=6&db=m Pilot randomized phase II study of celecoxib in oral premalignant lesions. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408893&form=6&db=m Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cells. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18443952&form=6&db=m Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18444251&form=6&db=m Overexpression of cyclooxygenase-2 (COX-2) in the mouse urinary bladder induces the expression of immune- and cell proliferation-related genes. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462368&form=6&db=m COX-2 expression in sporadic colorectal adenomatous polyps is linked to adenoma characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18467819&form=6&db=m Expression of cytosolic phospholipase A2 and cyclooxygenase 2 and their significance in human oral mucosae, dysplasias and squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18485889&form=6&db=m Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18493301&form=6&db=m Nucleobindin co-localizes and associates with cyclooxygenase (COX)-2 in human neutrophils. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18543083&form=6&db=m Angiotensin II bi-directionally regulates cyclooxygenase-2 expression in intestinal epithelial cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18565574&form=6&db=m Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571838&form=6&db=m The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18611916&form=6&db=m Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617777&form=6&db=m Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645019&form=6&db=m Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18646190&form=6&db=m Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18648741&form=6&db=m Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18665070&form=6&db=m Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18674950&form=6&db=m Actinic cheilitis: Epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18683800&form=6&db=m [The effect of siRNA on inhibiting cyclooxygenase-2 gene expression in gastric adenocarcinoma cell] causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18687669&form=6&db=m Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18700688&form=6&db=m Genetic and microenvironmental implications in prostate cancer progression and metastasis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18708588&form=6&db=m NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18717758&form=6&db=m Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18752906&form=6&db=m Analysis of Cox-2 expression in Wilms' tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758643&form=6&db=m Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18790560&form=6&db=m Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18819100&form=6&db=m Inflammatory processes of prostate tissue microenvironment drive rat prostate carcinogenesis: preventive effects of celecoxib. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18840457&form=6&db=m o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18841789&form=6&db=m [Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18848748&form=6&db=m Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-kappaB and C/EBP as potential targets. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18926952&form=6&db=m Anti-metastatic Action of Non-steroidal Anti-inflammatory Drugs. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952571&form=6&db=m Cyclooxygenases: structural and functional insights. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952595&form=6&db=m Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18974063&form=6&db=m COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18985541&form=6&db=m Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18988924&form=6&db=m Cancer morphogenesis: role of mitochondrial failure. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19018769&form=6&db=m Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19031117&form=6&db=m Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19042113&form=6&db=m Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056653&form=6&db=m Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060633&form=6&db=m Cyclooxygenase polymorphisms in gastric and colorectal carcinogenesis: are conclusive results available? causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19073879&form=6&db=m Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19075598&form=6&db=m Protective effect of NSAIDs on cancer and influence of COX-2 C(-765G) genotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19077474&form=6&db=m [The change of cyclooxygenase-2 and inducible nitric oxide synthase in the gastric mucosa one year after eradication of Helicobacter pylori] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19088039&form=6&db=m Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19101649&form=6&db=m PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19102009&form=6&db=m EGFR, HER-2 and COX-2 levels in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107602&form=6&db=m Expression of COX-2 in Stomach Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19108014&form=6&db=m Decreased expression of 15-hydroxyprostaglandin dehydrogenase in gastric carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19110997&form=6&db=m A selective cyclooxygenase-2 inhibitor prevents inflammation-related squamous cell carcinogenesis of the forestomach via duodenogastric reflux in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116880&form=6&db=m Probiotics regulate the expression of COX-2 in intestinal epithelial cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19117991&form=6&db=m K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19118057&form=6&db=m Cyclooxygenase-2 is an independent prognostic factor in gastric carcinoma patients receiving adjuvant chemotherapy and is not associated with EBV infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19124115&form=6&db=m Increased cyclooxygenase-2 expression in juvenile polyposis syndrome. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132985&form=6&db=m Prognostic value of COX-2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138835&form=6&db=m A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19154413&form=6&db=m Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19167045&form=6&db=m Relationship between cysteinyl-leukotriene-1 receptor and human transitional cell carcinoma in bladder. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19174152&form=6&db=m Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19176489&form=6&db=m Molecular Characterization of Feline COX-2 and Expression in Feline Mammary Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19188749&form=6&db=m COX-2 expression does not correlate with microvessel density in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201881&form=6&db=m Lipopolysaccharide initiates a positive feedback of epidermal growth factor receptor signaling by prostaglandin E2 in human biliary carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203768&form=6&db=m COX-2 expression in canine normal and neoplastic mammary gland. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203995&form=6&db=m Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19205707&form=6&db=m Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208339&form=6&db=m The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19221092&form=6&db=m Protein kinase Cbeta is an effective target for chemoprevention of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19226541&form=6&db=m Effect of non-steroidal anti-inflammatory drugs on non-melanoma skin cancer incidence in the SKICAP-AK trial. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236238&form=6&db=m Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239949&form=6&db=m Immunoexpression of cyclooxygenase-2 and p53 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250220&form=6&db=m Cyclooxygenase-2 expression in chronic liver diseases and hepatocellular carcinoma: an immunohistochemical study . causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258012&form=6&db=m Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268443&form=6&db=m Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19278989&form=6&db=m PGE2 production in oral cancer cell lines is COX-2-dependent. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280666&form=6&db=m COX-2 polymorphisms and the risk for head and neck cancer in white patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287981&form=6&db=m Inhibitory effect of sulindac on DMBA-induced hamster cheek pouch carcinogenesis and its derived cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19300368&form=6&db=m Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in Oral Squamous Cell Carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19307727&form=6&db=m Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19309229&form=6&db=m Celecoxib and melatonin in prevention of female rat mammary carcinogenesis. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19318492&form=6&db=m Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19321801&form=6&db=m Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336727&form=6&db=m Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19340409&form=6&db=m Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19346994&form=6&db=m Clinicopathological Correlations of Cyclooxygenase-2, MDM2, and p53 Expressions in Surgically Resectable Pancreatic Invasive Ductal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351509&form=6&db=m [Expression of IGF-IR and COX-2 in renal cell carcinoma and their relationship with cell proliferation.] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19372053&form=6&db=m Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19375854&form=6&db=m A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19379296&form=6&db=m Expression and regulation of cyclooxygenase-2 in normal and neoplastic canine keratinocytes. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19392653&form=6&db=m The cyclooxygenase-2 inhibitor etoricoxib is a potent chemopreventive agent of colon carcinogenesis in the rat model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19393083&form=6&db=m Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19407554&form=6&db=m Proteomics reveals protein profile changes in cyclooxygenase-2 inhibitor-treated endometrial cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428370&form=6&db=m Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19431205&form=6&db=m Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19457650&form=6&db=m Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19465063&form=6&db=m Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19484991&form=6&db=m [Expression and clinical significance of hypoxia-inducible factor-1alpha and cyclooxygenase-2 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19505386&form=6&db=m Effects of rich-in-fat diets and highly selective COX-2 inhibitors on 7,12-dimethylbenz-(A)-anthracene-induced tumor growth. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519538&form=6&db=m Selective cyclooxygenase-2 (COX-2) inhibitors used for preventing or regressing cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19528445&form=6&db=m Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19539802&form=6&db=m Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549265&form=6&db=m Meta-analysis: clinicopathological and prognostic significance of cyclooxygenase-2 expression on oesophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19559517&form=6&db=m Cox-2 expression in ovarian malignancies: a review of the clinical aspects. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19571668&form=6&db=m Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyclooxygenase-2 inhibition as chemoprevention for rat bladder carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19580182&form=6&db=m COX-2, VEGF and tumour angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19580343&form=6&db=m Immunohistochemical markers of proliferation and vascularisation in preneoplastic bronchial lesions and invasive non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19585617&form=6&db=m Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19621664&form=6&db=m Expression of c-erbB-2 and cyclooxygenase-2 in intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638428&form=6&db=m HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19639188&form=6&db=m Peroxisome proliferator-activated receptor delta and gastric cancer (Review). causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19647091&form=6&db=m Inhibition of prostaglandin E(2) signaling through the EP(1) receptor does not affect prostacyclin production in human endothelial cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19691646&form=6&db=m Cyclooxygenase-2 (COX-2) expression in canine intracranial meningiomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723044&form=6&db=m Cyclooxygenase-2 expression in cervical intraepithelial neoplasia. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19748995&form=6&db=m Ligand Activation of Peroxisome Proliferator-Activated Receptor-{beta}/{delta} (PPAR{beta}/{delta}) and Inhibition of Cyclooxygenase 2 (COX2) Enhances Inhibition of Skin Tumorigenesis. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19754418&form=6&db=m Inhibitors of the Microsomal Prostaglandin E(2) Synthase-1 as Alternative to Non Steroidal Anti-inflammatory Drugs (NSAIDs) - A Critical Review. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19763245&form=6&db=m Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19773434&form=6&db=m Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776176&form=6&db=m Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MKK4 and PI-3 kinase. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776181&form=6&db=m Olive Leaf Extract and Its Main Component Oleuropein Prevent Chronic Ultraviolet B Radiation-Induced Skin Damage and Carcinogenesis in Hairless Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776642&form=6&db=m omega-3 Fatty Acids, Genetic Variants in COX-2 and Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19779968&form=6&db=m Silibinin Suppresses Spontaneous Tumorigenesis in APC (min/+) Mouse Model by Modulating Beta-Catenin Pathway. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19788894&form=6&db=m Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19795129&form=6&db=m Impact of group IVA cytosolic phospholipase A ( 2 ) gene polymorphisms on phenotypic features of patients with familial adenomatous polyposis. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808956&form=6&db=m Tpl2 is a key mediator of arsenite-induced signal transduction. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19818596&form=6&db=m Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19821125&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19826177&form=6&db=m Helicobacter pylori infection in gastric cancerogenesis. ongoing research,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19836060&form=6&db=m Prognostic relevance of cyclooxygenase-2 (COX-2) expression in Chinese patients with prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19842220&form=6&db=m Short-term Celecoxib intervention is a safe and effective chemopreventive for gastric carcinogenesis based on a Mongolian gerbil model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19845533&form=6&db=m Cyclooxygenase-2 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19876598&form=6&db=m Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895368&form=6&db=m Modulation of tumorigenesis and oestrogen receptor-alpha expression by cell culture conditions in a stem cell-derived breast epithelial cell line. ongoing research,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895739&form=6&db=m [Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19897661&form=6&db=m PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19930591&form=6&db=m Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19940363&form=6&db=m Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19960513&form=6&db=m Caveolin-1 facilitates cyclooxygenase-2 protein degradation. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20001974&form=6&db=m Cyclo-oxygenase 2 up-regulates the effect of multidrug resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20020969&form=6&db=m Chemopreventive effects of nonsteroidal anti-inflammatory drugs on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20033868&form=6&db=m The Licorice Flavonoid Isoliquiritigenin Suppresses Phorbol Ester-induced Cyclooxygenase-2 Expression in the Non-tumorigenic MCF-10A Breast Cell Line. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051365&form=6&db=m Beyond the scalpel: targeting hedgehog in skin cancer prevention. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051374&form=6&db=m Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20068165&form=6&db=m HEF1 is a crucial mediator of the proliferative effects of prostaglandin E(2) on colon cancer cells. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096072&form=6&db=m Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20117092&form=6&db=m Gq protein mediates UVB-induced cyclooxygenase-2 expression by stimulating HB-EGF secretion from HaCaT human keratinocytes. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20122271&form=6&db=m Synergistic effect of gefitinib and rofecoxib in mesothelioma cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20155627&form=6&db=m Piceatannol inhibits phorbol ester-induced NF-kappa B activation and COX-2 expression in cultured human mammary epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179211&form=6&db=m Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200425&form=6&db=m PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20202090&form=6&db=m Celecoxib enhances the inhibitory effect of cisplatin on Tca8113 cells in human tongue squamous cell carcinoma in vivo and in vitro. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20204254&form=6&db=m Effect of etoricoxib, a cyclooxygenase-2 selective inhibitor on aberrant crypt formation and apoptosis in 1,2 dimethyl hydrazine induced colon carcinogenesis in rat model. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209608&form=6&db=m Intratumoral forkhead box P3-positive regulatory T cells predict poor survival in cyclooxygenase-2-positive uveal melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20210736&form=6&db=m The effects of radix curcumae extract on expressions of VEGF, COX-2 and PCNA in gastric mucosa of rats fed with MNNG. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20218615&form=6&db=m Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233591&form=6&db=m Induction of pulmonary carcinogenesis in Wistar rats by a single dose of 9, 10 Dimethylbenz(a)anthracene (DMBA) and the chemopreventive role of Diclofenac. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233901&form=6&db=m 5-deoxykaempferol plays a potential therapeutic role by targeting multiple signaling pathways in skin cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20237896&form=6&db=m COX-2 is associated with proliferation and apoptosis markers and serves as an independent prognostic factor in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346139&form=6&db=m Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20348947&form=6&db=m The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20381235&form=6&db=m Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20396589&form=6&db=m Quercetin Suppresses Early Colon Carcinogenesis Partly through Inhibition of Inflammatory Mediators. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20405173&form=6&db=m Suppression of the Inflammatory Cascade is Implicated in Resveratrol Chemoprevention of Experimental Hepatocarcinogenesis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406206&form=6&db=m Differential Inhibitory Effects of the Polyphenol Ellagic Acid on Inflammatory Mediators NF-kappaB, iNOS, COX-2, TNF-alpha, and IL-6 in 1,2-Dimethylhydrazine-Induced Rat Colon Carcinogenesis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412400&form=6&db=m Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428208&form=6&db=m COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF). causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20429377&form=6&db=m [Expression and significance of COX-2 and S-100 positive dendritic cell in laryngeal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20436219&form=6&db=m Bile acids are multifunctional modulators of the Barrett's carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446925&form=6&db=m The value of MG7-Ag and COX-2 for predicting malignancy in gastric precancerous lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20484034&form=6&db=m Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20488613&form=6&db=m Dysregulation of cellular signaling in gastric cancer. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20495296&form=6&db=m Coenzyme Q10 attenuated DMH-induced precancerous lesions in SD rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20514441&form=6&db=m Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20536243&form=6&db=m Ethyl acetate fraction of adlay bran ethanolic extract inhibits oncogene expression and suppresses DMH-induced preneoplastic lesions of the colon in F344 rats through an anti-inflammatory pathway. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20536410&form=6&db=m COX-2 expression in human breast carcinomas: correlation with clinicopathological features and prognostic molecular markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20571779&form=6&db=m EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20571967&form=6&db=m Hypermethylation of RAR?2 correlates with high COX-2 expression and poor prognosis in patients with colorectal carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20577575&form=6&db=m Posttranscriptional Regulation of Cyclooxygenase 2 Expression in Colorectal Cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592893&form=6&db=m Cox-2 and IL-10 polymorphisms and association with squamous cell carcinoma of the head and neck in a Korean sample. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609543&form=6&db=m Ursodeoxycholic acid and chemoprevention of colorectal cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20615394&form=6&db=m Targeting COX-2 expression by natural compounds: A promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20625420&form=6&db=m RNAi-based strategies for cyclooxygenase-2 inhibition in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631072&form=6&db=m Suppression of integrin alpha3beta1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20633535&form=6&db=m Regular exercise reduces colon tumorigenesis associated with suppression of iNOS. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635052&form=6&db=m [Expression of NF-kappaB and COX-2 in tongue squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635443&form=6&db=m Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20645161&form=6&db=m Techniques used to study regulation of cyclooxygenase-2 promoter sites. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20649594&form=6&db=m Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651346&form=6&db=m COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651971&form=6&db=m Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20653782&form=6&db=m Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20676755&form=6&db=m Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20681671&form=6&db=m Pterostilbene inhibits colorectal aberrant crypt foci (ACF) and colon carcinogenesis via suppression of multiple signal transduction pathways in azoxymethane-treated mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20694294&form=6&db=m Evaluation of chemopreventive response of two cycloxygenase-2 inhibitors, etoricoxib and diclofenac in rat colon cancer using FTIR and NMR spectroscopic techniques. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717114&form=6&db=m Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20718052&form=6&db=m Chemoprevention of colonic tumorigenesis by dietary hydroxylated polymethoxyflavones in azoxymethane-treated mice. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20728343&form=6&db=m Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20827306&form=6&db=m Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor ?B Is a Steady Feature of Urinary Bladder Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20837956&form=6&db=m Phase III randomized trial assessing rofecoxib in the adjuvant setting of colorectal cancer: final results of the VICTOR trial. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20846124&form=6&db=m Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of gallbladder carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20846456&form=6&db=m Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20857495&form=6&db=m Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20864903&form=6&db=m Expression of cyclooxygenase-2 in colonic polyps. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876365&form=6&db=m Cyclooxygenase-2 Expression in Animal Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878073&form=6&db=m Down-regulation of CacyBP is associated with poor prognosis and the effects on COX-2 expression in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878085&form=6&db=m Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20879982&form=6&db=m Exploiting cyclooxygenase-(in)dependent properties of COX-2 inhibitors for malignant glioma therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20883688&form=6&db=m Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960565&form=6&db=m Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042743&form=6&db=m R-etodolac induces E-cadherin and suppresses colitis-related mouse colon tumorigenesis. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042835&form=6&db=m Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21044318&form=6&db=m Increasing CD44+/CD24- tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21058188&form=6&db=m Avenanthramides inhibit proliferation of human colon cancer cell lines in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21103921&form=6&db=m Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21150337&form=6&db=m LKB1/PEA3/?Np63 pathway regulates PTGS-2 (COX-2) transcription in lung cancer cells upon cigarette smoke exposure. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21159610&form=6&db=m Chemoprevention of chemically induced skin tumorigenesis by ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase 2. therapeutic application,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21160593&form=6&db=m Anti-carcinogenic properties of curcumin on colorectal cancer. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21163769&form=6&db=m [Application of non-steroidal anti-inflammatory drugs to enhance 5-fluorouracil efficacy in experimental systems]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21185708&form=6&db=m Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187081&form=6&db=m Cyclooxygenase-2 in oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21198287&form=6&db=m Anti-Proliferative and Apoptotic Effects of Etoricoxib, a Selective COX-2 Inhibitor, on 1,2-Dimethylhydrazine Dihydrochloride-Induced Colon Carcinogenesis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205091&form=6&db=m Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205743&form=6&db=m The role of NAG-1/GDF15 in the inhibition of intestinal polyps in APC/Min mice by sulindac. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21245412&form=6&db=m Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21251952&form=6&db=m HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21258746&form=6&db=m Potential molecular targets in chemopreventative action of celecoxib: a proteomics analysis of J774.A1 macrophage-like cell line. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21262157&form=6&db=m [Cyclooxygenase-2, inducible nitric oxide synthase protein expression and vasculature during experimental rat lung carcinogenesis.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268131&form=6&db=m p38 MAP kinase plays a functional role in UVB-Induced mouse skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268133&form=6&db=m Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1? and VEGF. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21275453&form=6&db=m A new cyclo-oxygenase-2 gene variant in the Han Chinese population is associated with an increased risk of gastric carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21280565&form=6&db=m Celecoxib mitigates cigarette smoke induced oxidative stress in mice. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21304218&form=6&db=m Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21308683&form=6&db=m Hypermethylation of tumor-related genes in tunisian patients with gastric carcinoma: Clinical and biological significance. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21320400&form=6&db=m [Cyclooxygenase-2 expression in female pulmonary adenocarcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21354147&form=6&db=m Microsomal Prostaglandin E Synthase-1 Inhibits PTEN and Promotes Experimental Cholangiocarcinogenesis and Tumor Progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21356386&form=6&db=m Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360269&form=6&db=m Expression Profile as Predictor of Relapse after Adjuvant Treatment in Gastric Cancer. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360625&form=6&db=m Combination of a ptgs2 inhibitor and an epidermal growth factor receptor-signaling inhibitor prevents tumorigenesis of oligodendrocyte lineage-derived glioma-initiating cells. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21371829&form=6&db=m Immunohistochemical COX-2 overexpression correlates with HER-2/neu overexpression in invasive breast carcinomas: A pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21432290&form=6&db=m Types and amount of dietary fat and colon cancer risk: Prevention by omega-3 fatty acid-rich diets. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21435744&form=6&db=m [Aspirin in the prevention of colorectal cancer.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21437756&form=6&db=m COX2 Expression Predicts Resistance to Chemoradiotherapy in Esophageal Squamous Cell Carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21475807&form=6&db=m Expression of cysteinylLT1 receptor in human testicular cancer and growth reduction by its antagonist through apoptosis. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479395&form=6&db=m The cysteinylLT1 receptor in human renal cell carcinoma. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21481000&form=6&db=m Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21488197&form=6&db=m Effect of pertussis toxin and herbimycin A on proteinase-activated receptor 2-mediated cyclooxygenase 2 expression in Helicobacter pylori-infected gastric epithelial AGS cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21496105&form=6&db=m Potential relevance of cyclooxygenase-2 expression in keratocystic odontogenic tumours - an immunohistochemical study. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21545294&form=6&db=m Molecular Mechanisms Underlying Chemopreventive Activities of Glycyrrhizic Acid against UVB-Radiation-Induced Carcinogenesis in SKH-1 Hairless Mouse Epidermis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21561856&form=6&db=m Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21572400&form=6&db=m Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21600223&form=6&db=m COX-2 expression is correlated with VEGF-C, lymphangiogenesis and lymph node metastasis in human cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21601872&form=6&db=m Immunohistochemical Detection of COX-2 in Feline and Canine Actinic Keratoses and Cutaneous Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21623034&form=6&db=m Study on cow ghee versus soybean oil on 7,12-dimethylbenz(a)-anthracene induced mammary carcinogenesis & expression of cyclooxygenase-2 & peroxisome proliferators activated receptor-? in rats. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21623164&form=6&db=m Targeting the inflammatory pathways to enhance chemotherapy of cancer. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21633290&form=6&db=m Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21678409&form=6&db=m Interplay between membrane lipid peroxidation, transglutaminase activity and cyclooxygenase 2 expression in the tissue adjoining to breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705614&form=6&db=m Luteolin, a Novel Natural Inhibitor of Tumor Progression Locus 2 Serine/Threonine Kinase, Inhibits Tumor Necrosis Factor-{alpha}-Induced Cyclooxygenase-2 Expression in JB6 Mouse Epidermis Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21733822&form=6&db=m Lung cancer chemoprevention with celecoxib in former smokers. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21744257&form=6&db=m Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21771729&form=6&db=m Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21830391&form=6&db=m Tristetraprolin downregulates the expression of both VEGF and COX-2 in human colon cancer. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21853475&form=6&db=m UVB radiation-induced ?-catenin signaling is enhanced by COX-2 expression in keratinocytes. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21896084&form=6&db=m Gastric cancer: basic aspects. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21926111&form=6&db=m Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21980345&form=6&db=m Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21993002&form=6&db=m Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001128&form=6&db=m Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22009064&form=6&db=m Cyclooxygenase- and lipoxygenase-mediated DNA damage. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22023987&form=6&db=m Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22034055&form=6&db=m Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038018&form=6&db=m Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22039326&form=6&db=m Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22042094&form=6&db=m Cyclooxygenase-2 expression in central giant cell lesion of the jaws: an immunohistochemical study. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22082586&form=6&db=m ?-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22121107&form=6&db=m Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22131058&form=6&db=m Immunodetection of cyclooxygenase-2 (COX-2) is restricted to tissue macrophages in normal rat liver and to recruited mononuclear phagocytes in liver injury and cholangiocarcinoma. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159471&form=6&db=m Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: involvement of CCAAT/enhancer binding protein ? and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160279&form=6&db=m Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22165968&form=6&db=m Characterization of the Prostaglandin E2 path way in a Rat Model of Esophageal Adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22181070&form=6&db=m Phloretin Inhibits Phorbol Ester-Induced Tumor Promotion and Expression of Cyclooxygenase-2 in Mouse Skin: Extracellular Signal-Regulated Kinase and Nuclear Factor-?B as Potential Targets. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22200969&form=6&db=m The effects of cyclooxygenase-2 gene silencing by siRNA on cell proliferation, cell apoptosis, cell cycle and tumorigenicity of Capan-2 human pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203921&form=6&db=m Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesions. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22213328&form=6&db=m Expression of prostaglandin- and vitamin D-metabolising enzymes in benign and malignant breast cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22218775&form=6&db=m The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22223226&form=6&db=m Time-selective chemoprevention of vitamin E and selenium on esophageal carcinogenesis in rats: The possible role of nuclear factor kappaB signaling pathway. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22242594&form=6&db=m Antitumor effect of a generation 4 polyamidoamine dendrimer/cyclooxygenase-2 antisense oligodeoxynucleotide complex on breast cancer in vitro and in vivo. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22247036&form=6&db=m Cyclooxygenase-2 expression and clinical parameters in laryngeal squamous cell carcinoma, vocal fold nodule, and laryngeal atypical hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249792&form=6&db=m Cyclooxygenase-2 and human epidermal growth factor receptor type 2 (HER-2) expression simultaneously in invasive and in situ breast ductal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22252523&form=6&db=m Antiproliferative effects of selective cyclooxygenase-2 inhibitor modulated by nimotuzumab in estrogen-dependent breast cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22263894&form=6&db=m Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2'-Des-methyl-sulindac Sulfide Scaffold. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22272632&form=6&db=m Prostaglandin E2 (PGE2) in portal blood in patients with pancreatic tumor--a single institution series. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22288910&form=6&db=m Cyclooxygenase-2 Expression Is Up-regulated by 2-Aminobiphenyl in a ROS and MAPK-Dependent Signaling Pathway in a Bladder Cancer Cell Line. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22290291&form=6&db=m The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-?B, MAPK, and p53 signaling. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340386&form=6&db=m Cyclooxygenase-2 promoter polymorphism -899G/C is associated with hepatitis B-related liver cancer in a Chinese population of Gansu province. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22344367&form=6&db=m Inhibition of cyclooxygenase-2 by tetramethylpyrazine and its effects on A549 cell invasion and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22385256&form=6&db=m A Genetic Variant in 3'-Untranslated Region of Cyclooxygenases-2 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22387750&form=6&db=m Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22409848&form=6&db=m [Expressions and significance of COX-2 and P-gp in human hepatocellular cacinoma tissues]. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22411738&form=6&db=m Chemopreventive effects of NSAIDs as inhibitors of cyclooxygenase-2 and inducers of apoptosis in experimental lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22419920&form=6&db=m Cyclooxygenase-2 expression and its association with thyroid lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22441428&form=6&db=m Dolastatin 15, a mollusk linear peptide, and Celecoxib, a selective cyclooxygenase-2 inhibitor, prevent preneoplastic colonic lesions and induce apoptosis through inhibition of the regulatory transcription factor NF-?B and an inflammatory protein, iNOS. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22463588&form=6&db=m Cyclooxygenase-2 (COX-2) mediates arsenite inhibition of UVB-induced cellular apoptosis in mouse epidermal Cl41 cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22474323&form=6&db=m Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22480996&form=6&db=m Aspirin and non-aspirin non-steroidal anti-inflammatory drug use and risk of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22493349&form=6&db=m 5-aminosalicylic acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22502692&form=6&db=m Cyclooxygenase-2 expression is not a marker of poor survival in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22514893&form=6&db=m Protective effect of berberine on expression pattern of apoptotic, cell proliferative, inflammatory and angiogenic markers during 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534023&form=6&db=m Pattern of expression of cyclooxygenase-2 in malignant transformation of sinonasal inverted papilloma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22546756&form=6&db=m Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561258&form=6&db=m PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3? signaling pathway in DMH induced early colon carcinogenesis in rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22577245&form=6&db=m Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22610150&form=6&db=m Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22623379&form=6&db=m Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor, celecoxib and dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis. therapeutic application,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22644960&form=6&db=m Nonsteroidal anti-inflammatory drugs and the risk of skin cancer: A population-based case-control study. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22658594&form=6&db=m Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE?. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22670549&form=6&db=m Hyperbaric oxygen therapy reduces COX-2 expression in a dimethylhydrazine-induced rat model of colorectal carcinogenesis. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22710400&form=6&db=m The establishment of supramolecular immunobead real-time PCR and the identification of Cox-2 as a metastasis-related marker in colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22715028&form=6&db=m Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22729105&form=6&db=m Selective cyclooxygenase-2 inhibitor prevents cisplatin-induced tumorigenesis in A/J mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22740976&form=6&db=m Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22751903&form=6&db=m Antitumor and anti-metastatic effects of cyclooxygenase-2 inhibition by celecoxib on human colorectal carcinoma xenografts in nude mouse rectum. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22760862&form=6&db=m Geraniol inhibits murine skin tumorigenesis by modulating COX-2 expression, Ras-ERK1/2 signaling pathway and apoptosis. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22808264&form=6&db=m The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22818026&form=6&db=m Nuclear factor ?B and cyclooxygenase-2 immunoexpression in oral dysplasia and oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22822908&form=6&db=m Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22843946&form=6&db=m Association Between COX-2 Expression and Effectiveness of COX-2 Inhibitors in a Phase II Trial in Patients with Metastatic Colorectal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22851770&form=6&db=m Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22863264&form=6&db=m Genetic polymorphism in cyclooxygenase-2 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22884582&form=6&db=m IL1?-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22885178&form=6&db=m Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22893198&form=6&db=m Mechanistic Aspects of COX-2 Expression in Colorectal Neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22893202&form=6&db=m New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22922684&form=6&db=m The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22950494&form=6&db=m Chemoprevention of Cancers in Gastrointestinal Tract with Cyclooxygenase 2 Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22955327&form=6&db=m Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agents. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22960430&form=6&db=m Eicosanoid profiling in colon cancer: Emergence of a pattern. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22986104&form=6&db=m Effects of C-Phycocyanin on the representative genes of tumor development in mouse skin exposed to 12-O-tetradecanoyl-phorbol-13-acetate. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23013439&form=6&db=m Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23033540&form=6&db=m The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23053397&form=6&db=m The role of PGE2-associated inflammatory responses in gastric cancer development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23059845&form=6&db=m Cyclooxygenase-2 over-expression inhibits liver apoptosis induced by hyperglycemia. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23102197&form=6&db=m [Neoplastic effect of indomethacin in N-methyl-N-nitrosourea induced mammary carcinogenesis in female rats]. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23109673&form=6&db=m Effect of sphingosine kinase 1 inhibition on blood pressure. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23125227&form=6&db=m Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23128938&form=6&db=m Effects of IL-1? on the proliferation and apoptosis of gastric epithelial cells and acid secretion from isolated rabbit parietal cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23141895&form=6&db=m Chemoprevention of colorectal cancer with ursodeoxycholic acid: pro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23192657&form=6&db=m Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23260331&form=6&db=m Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23293573&form=6&db=m Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23307260&form=6&db=m Reduced group IVA phospholipase A2 expression is associated with unfavorable outcome for patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23307625&form=6&db=m Effective suppression of azoxymethane-induced aberrant crypt foci formation in mice with citrus peel flavonoids. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23321929&form=6&db=m Cyclooxygenase-2 Generates the Endogenous Mutagen trans-4-Hydroxy-2-nonenal in Enterococcus faecalis-Infected Macrophages. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23343963&form=6&db=m Cyclooxygenase, cancer stem cells and DNA methylation play important roles in colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23372950&form=6&db=m Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376640&form=6&db=m Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23380442&form=6&db=m Pin1 is required for ultraviolet A-stimulated cyclooxygenase-2 induction in mouse epidermal cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23435965&form=6&db=m Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23457529&form=6&db=m Altered prostanoid signaling contributes to increased skin tumorigenesis in tpl2 knockout mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23494177&form=6&db=m The association between cyclooxygenase-2 1195 G/A polymorphism and hepatocellular carcinoma: evidence from a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23494562&form=6&db=m Prostaglandin E2 receptor EP1 phosphorylate CREB and mediates MMP2 expression in human cholangiocarcinoma cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520664&form=6&db=m Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23579063&form=6&db=m Progression of liver oncogenesis in the double transgenic mice c-myc/TGF ? is not enhanced by cyclooxygenase-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23580446&form=6&db=m Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23601296&form=6&db=m [Mechanisms of EGF regulation of COX-2 through the STAT5 signaling pathway in human lung adenocarcinoma A549 cells]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23620771&form=6&db=m The association between COX-2 polymorphisms and hematologic toxicity in patients with advanced non-small-cell lung cancer treated with platinum-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23682075&form=6&db=m Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23715757&form=6&db=m Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717003&form=6&db=m Up-regulation of cyclooxygenase 2 and matrix metalloproteinases-2 and -9 in cutaneous squamous cell carcinoma: active role of inflammation and tissue remodeling in carcinogenesis. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23722652&form=6&db=m N-methylnitrosourea aggravates gastrointestinal polyposis in Lkb1+/- mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23741059&form=6&db=m Epithelial-Specific Deletion of 11?-HSD2 Hinders Apcmin/+ Mouse Tumorigenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23776069&form=6&db=m The -1195G allele increases the transcriptional activity of cyclooxygenase-2 gene (COX-2) in colon cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23846978&form=6&db=m Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851751&form=6&db=m Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23875171&form=6&db=m COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898071&form=6&db=m High cyclooxygenase-2 expression is associated with advanced stages in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23900502&form=6&db=m Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: ?mplications for cholangiocarcinogenesis. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23955118&form=6&db=m Toll-like receptor 4 activation in Barrett's esophagus results in a strong increase in COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23958541&form=6&db=m A High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973650&form=6&db=m Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to G?i and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24021750&form=6&db=m Impact of non-steroidal anti-inflammatory drugs on gastrointestinal cancers: Current state-of-the science. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24037722&form=6&db=m COX-2, TFF1, and Src define better prognosis in young patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24056964&form=6&db=m EIF3i promotes colon oncogenesis by regulating COX-2 protein synthesis and ?-catenin activation. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24082331&form=6&db=m Proapoptotic, Anti-Cell Proliferative, Anti-Inflammatory and Anti-Angiogenic Potential of Carnosic Acid during 7,12 Dimethylbenz[a]Anthracene-Induced Hamster Buccal Pouch Carcinogenesis. ongoing research,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085777&form=6&db=m Chemoprevention of Head and Neck Cancer with Celecoxib and Erlotinib: Results of a Phase 1b and Pharmacokinetic Study. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098505&form=6&db=m Select Dietary Phytochemicals Function as Inhibitors of COX-1 but Not COX-2. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127267&form=6&db=m A positive feedback loop between STAT3 and cyclooxygenase-2 gene may contribute to Helicobacter pylori-associated human gastric tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24137401&form=6&db=m Cyclooxygenase-2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24146280&form=6&db=m Cyclooxygenase 2 promoted the tumorigenecity of pancreatic cancer cells. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24151540&form=6&db=m Colon Macrophages Polarized by Commensal Bacteria Cause Colitis and Cancer through the Bystander Effect. ongoing research,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24176842&form=6&db=m Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24178897&form=6&db=m Cyclooxygenase-2 expression is associated with poor overall survival of patients with gastric cancer: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24212943&form=6&db=m Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24220240&form=6&db=m 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24221358&form=6&db=m Saturated Fatty Acids Up-regulate COX-2 Expression in Prostate Epithelial Cells via Toll-like Receptor 4/NF-?B Signaling. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24259966&form=6&db=m Role of cyclooxygenase-2 in gastric cancer development and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24270349&form=6&db=m An inflammatory mediator, prostaglandin E2, in colorectal cancer. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24364787&form=6&db=m Silibinin inhibits tumor promotional triggers and tumorigenesis against chemically induced two-stage skin carcinogenesis in Swiss albino mice: possible role of oxidative stress and inflammation. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469308&form=6&db=m Cell-type-specific roles for COX-2 in UVB-induced skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24470172&form=6&db=m Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24474144&form=6&db=m A newly synthesized compound, 4'-geranyloxyferulic acid-N(omega)-nitro-l-arginine methyl ester suppresses inflammation-associated colorectal carcinogenesis in male mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24516579&form=6&db=m Overexpression of cyclooxygenase-2 in malignant peripheral nerve sheath tumor and selective cyclooxygenase-2 inhibitor-induced apoptosis by activating caspases in human malignant peripheral nerve sheath tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24589238&form=6&db=m 5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24590894&form=6&db=m Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24603686&form=6&db=m The Bitter Barricading of Prostaglandin Biosynthesis Pathway: Understanding the Molecular Mechanism of Selective Cyclooxygenase-2 Inhibition by Amarogentin, a Secoiridoid Glycoside from Swertia chirayita. therapeutic application,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24684440&form=6&db=m Levuglandin Forms Adducts with Histone H4 in a Cyclooxygenase-2-Dependent Manner, Altering Its Interaction with DNA. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24688218&form=6&db=m Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc (Min/+) mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24704993&form=6&db=m MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24720952&form=6&db=m COX-2 polymorphisms -765G?C and -1195A?G and hepatocellular carcinoma risk. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24742714&form=6&db=m Genistein inhibits phorbol ester-induced NF-?B transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/Rel in human mammary epithelial cells. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24789723&form=6&db=m Cyclooxygenase-2 Polymorphisms and Breast Cancer Associated Risk in Pakistani Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24793085&form=6&db=m Functionalized magnetic nanoparticles coupled with mass spectrometry for screening and identification of cyclooxygenase-1 inhibitors from natural products. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24801194&form=6&db=m Conjugates of cisplatin and cyclooxygenase inhibitors as potent antitumor agents overcoming cisplatin resistance. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24804836&form=6&db=m Cyclooxygenases: Mediators of UV-Induced Skin Cancer and Potential Targets for Prevention. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24818719&form=6&db=m The role of inflammation in inflammatory breast cancer. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24818733&form=6&db=m The role of inflammation in skin cancer. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819958&form=6&db=m A selective cyclooxygenase-2 inhibitor (Etodolac) prevents spontaneous biliary tumorigenesis in a hamster bilioenterostomy model. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24824420&form=6&db=m COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24834203&form=6&db=m Molecular profile of colorectal cancer in Indonesia: is there another pathway? causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24908358&form=6&db=m Aspirin may modify tumor microenvironment via antiplatelet effect. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24916702&form=6&db=m Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24927467&form=6&db=m Clinical evidence of the relationship between aspirin and breast cancer risk (review). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24935598&form=6&db=m The COX-2 -765 G>C polymorphism is associated with increased risk of gastric carcinogenesis in the Chinese Hui ethnic population. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24950702&form=6&db=m COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24983372&form=6&db=m Epidermal growth factor receptor (EGFR) and prostaglandin-endoperoxide synthase 2 (PTGS2) are prognostic biomarkers for patients with resected colorectal cancer liver metastases. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24989014&form=6&db=m Differential combined effect of COX inhibitors on cell survival suppressed by sorafenib in the HepG2 cell line. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24991108&form=6&db=m Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24998576&form=6&db=m Associations between single nucleotide polymorphisms of COX-2 and MMP-2 genes and colorectal cancer susceptibility in the Saudi population. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25024195&form=6&db=m Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25036966&form=6&db=m Bovine milk-derived ?-lactalbumin inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sodium sulfate-treated mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25057941&form=6&db=m Co-targeting c-Met and COX-2 leads to enhanced inhibition of lung tumorigenesis in a murine model with heightened airway HGF. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25063587&form=6&db=m Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25064845&form=6&db=m miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25077370&form=6&db=m COX-2, p16 and Ki67 expression in DCIS, microinvasive and early invasive breast carcinoma with extensive intraductal component. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25083990&form=6&db=m Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25114833&form=6&db=m Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25118473&form=6&db=m Breast cancer--new aspects of tumor biology: are calcitriol and cyclooxygenase-2 possible targets for breast cancer? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25121552&form=6&db=m Enalapril and ASS inhibit tumor growth in a transgenic mouse model of islet cell tumors. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25123248&form=6&db=m Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25166592&form=6&db=m Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25169526&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in colorectal adenocarcinoma: an immunohistochemical and histopathological study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25190466&form=6&db=m Discovery of lesser known flavones as inhibitors of NF-?B signaling in MDA-MB-231 breast cancer cells--A SAR study. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25199460&form=6&db=m Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25239551&form=6&db=m Influence of seasonal variation on Thymus longicaulis C. Presl chemical composition and its antioxidant and anti-inflammatory properties. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25278683&form=6&db=m Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25302170&form=6&db=m Cyclooxygenase-2 and the inflammogenesis of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25318459&form=6&db=m Conjugation of cisplatin analogues and cyclooxygenase inhibitors to overcome cisplatin resistance. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25335121&form=6&db=m Effects of cyclooxygenase-2 gene silencing on the biological behavior of SKOV3 ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25368279&form=6&db=m Evaluation of the contribution of cyclooxygenase 2 genotypes to breast cancer in Taiwan. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25371669&form=6&db=m COX-2 Inhibitors and Gastric Cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25395947&form=6&db=m Increased level of serum prostaglandin-2 in early stage of esophageal squamous cell carcinoma. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25405520&form=6&db=m JAK2 inhibitor blocks the inflammation and growth of esophageal squamous cell carcinoma in vitro through the JAK/STAT3 pathway. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422199&form=6&db=m MiR-1297 regulates the growth, migration and invasion of colorectal cancer cells by targeting cyclo-oxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25445582&form=6&db=m Oral administration of aflatoxin G? induces chronic alveolar inflammation associated with lung tumorigenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25487445&form=6&db=m Hypoxia promotes 786-O cells invasiveness and resistance to sorafenib via HIF-2?/COX-2. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25494807&form=6&db=m Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25511472&form=6&db=m Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25520883&form=6&db=m Prostaglandin receptors EP1-4 as a potential marker for clinical outcome in urothelial bladder cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579548&form=6&db=m Cyclo-oxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587354&form=6&db=m Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25622256&form=6&db=m Trianthema portulacastrum Linn. Displays Anti-Inflammatory Responses during Chemically Induced Rat Mammary Tumorigenesis through Simultaneous and Differential Regulation of NF-?B and Nrf2 Signaling Pathways. ongoing research,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25628848&form=6&db=m Direct Sequencing of Cyclooxygenase-2 (COX-2) Revealed an Intronic Variant rs201231411 in Iranian Patients with Pancreatic Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25644785&form=6&db=m Downregulation of PI3-K/Akt/PTEN pathway and activation of mitochondrial intrinsic apoptosis by Diclofenac and Curcumin in colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25676325&form=6&db=m Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25683901&form=6&db=m Immunohistochemical Expression of Cyclooxygenase-2 (COX-2) in Feline Endometrial Adenocarcinoma and in Normal and Hyperplastic Endometria. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25687474&form=6&db=m Modulation by Licofelone and Celecoxib of Experimentally Induced Cancer and Preneoplastic Lesions in Mice Exposed to Cigarette Smoke. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25692008&form=6&db=m Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1? in HCA-7 human colon cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25704623&form=6&db=m Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25734181&form=6&db=m Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25743830&form=6&db=m Cyclooxygenase-2 expression in invasive breast carcinomas of no special type and correlation with pathological profiles suggest a role in tumorigenesis rather than cancer progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25759517&form=6&db=m Involvement of NADPH oxidases in suppression of cyclooxygenase-2 promoter-dependent transcriptional activities by sesamol. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25811420&form=6&db=m Cyclooxygenase as a target in chemoprevention by probiotics during 1,2-dimethylhydrazine induced colon carcinogenesis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815878&form=6&db=m Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-?B and cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25825916&form=6&db=m Cell cycle regulation and apoptotic cell death in experimental colon carcinogenesis: intervening with cyclooxygenase-2 inhibitors. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25866543&form=6&db=m Antitumor Activities of Ethyl Acetate Extracts from Selaginella doederleinii Hieron In Vitro and In Vivo and Its Possible Mechanism. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25889730&form=6&db=m Opposing roles for mammary epithelial-specific PPAR? signaling and activation during breast tumour progression. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25941430&form=6&db=m Study of the effects of cyclooxygenase-2 inhibitor on the promotion of hepatic tumorigenesis in rats fed a high fat diet. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25949900&form=6&db=m Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against ?? T cell cytotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25962348&form=6&db=m Cyclooxygenase-2 - An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26011146&form=6&db=m Inhibition of 11?-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26021807&form=6&db=m Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26055124&form=6&db=m Red ginseng represses hypoxia-induced cyclooxygenase-2 through sirtuin1 activation. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26110572&form=6&db=m Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26176076&form=6&db=m Carcinogenic Potential of Biliary Epithelium of Congenital Choledochal Cyst Model in Rats: A Special Reference to HDAC Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26180515&form=6&db=m Cyclooxygeanse-2 promotes metastasis in osteosarcoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26238650&form=6&db=m DNA-hypomethylating agent, 5'-azacytidine, induces cyclooxygenase-2 expression via the PI3-kinase/Akt and extracellular signal-regulated kinase-1/2 pathways in human HT1080 fibrosarcoma cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251508&form=6&db=m Antiproliferative and anti-inflammatory properties of diindolylmethane and lupeol against N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis in experimental rats. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26300003&form=6&db=m Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26317548&form=6&db=m Dietary prevention of Helicobacter pylori-associated gastric cancer with kimchi. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26329416&form=6&db=m Inflammation and Oral Cancer: An Update Review on Targeted Therapies. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26334317&form=6&db=m Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26363638&form=6&db=m 3,5-Disubstituted Isoxazole Derivatives: Potential Inhibitors of Inflammation and Cancer. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26449252&form=6&db=m Helicobacter pylori, cyclooxygenase-2 and evolution of gastric lesions: results from an intervention trial in China. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26452035&form=6&db=m Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464196&form=6&db=m Modulation by aspirin and naproxen of nucleotide alterations and tumors in the lung of mice exposed to environmental cigarette smoke since birth. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26492449&form=6&db=m Chemopreventive activity of grape juice concentrate (G8000TM) on rat colon carcinogenesis induced by azoxymethane. ongoing research,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26511468&form=6&db=m Update on SAR Studies Toward New COX-1 Selective Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546977&form=6&db=m Bisphenol A-induced epithelial to mesenchymal transition is mediated by cyclooxygenase-2 up-regulation in human endometrial carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26549987&form=6&db=m Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26556718&form=6&db=m Cyclooxygenase-2, a Potential Therapeutic Target, Is Regulated by miR-101 in Esophageal Squamous Cell Carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26598915&form=6&db=m Potential of butein, a tetrahydroxychalcone to obliterate cancer. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26611322&form=6&db=m Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26618600&form=6&db=m Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26655637&form=6&db=m Anti-inflammatory and proapoptotic effects of umbelliferone in colon carcinogenesis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680871&form=6&db=m Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26745094&form=6&db=m Inhibition of NF-?B, Bcl-2 and COX-2 Gene Expression by an Extract of Eruca sativa Seeds during Rat Mammary Gland Carcinogenesis. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26771664&form=6&db=m Chemopreventive Effects of Eryngium foetidum L. Leaves on COX-2 Reduction in Mice Induced Colorectal Carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26774881&form=6&db=m hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26792550&form=6&db=m High COX-2 expression is associated with increased angiogenesis, proliferation and tumoural inflammatory infiltrate in canine malignant mammary tumours: a multivariate survival study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26801201&form=6&db=m Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26802941&form=6&db=m Apigenin inhibits COX-2, PGE2, and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26838195&form=6&db=m Combination between Taxol-Encapsulated Liposomes and Eruca sativa Seed Extract Suppresses Mammary Tumors in Female Rats Induced by 7,12 Dimethylbenz(?)anthracene. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26848699&form=6&db=m Role of the Slug Transcription Factor in Chemically-Induced Skin Cancer. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26861407&form=6&db=m Potential Benefits of Omega-3 Fatty Acids in Non-Melanoma Skin Cancer. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26862256&form=6&db=m Terminalia Chebula Attenuates DMBA/Croton Oil-Induced Oxidative Stress and Inflammation in Swiss albino Mouse Skin. ongoing research,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881519&form=6&db=m Cyclooxygenase-2 expression is associated with elevated aspartate aminotransferase level in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26884961&form=6&db=m Prostaglandin-endoperoxide synthase 2 (PTGS2) rs20417 polymorphism and prostate cancer risk: a meta analysis. diagnostic usage,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26888865&form=6&db=m Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26920155&form=6&db=m Cyclooxygenase 2 (rs2745557) Polymorphism and the Susceptibility to Benign Prostate Hyperplasia and Prostate Cancer in Egyptians. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26955911&form=6&db=m The use of cyclooxygenase-2 inhibitors for improvement of efficacy of radiotherapy in cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959737&form=6&db=m MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26969386&form=6&db=m Methyl syringate, a TRPA1 agonist represses hypoxia-induced cyclooxygenase-2 in lung cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26997150&form=6&db=m The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27039721&form=6&db=m Expression Patterns of Cancer Stem Cell Markers During Specific Celecoxib Therapy in Multistep Rat Colon Carcinogenesis Bioassays. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27072264&form=6&db=m Expression of COX-2 and p53 in juvenile polyposis coli and its correlation with adenomatous changes. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27159630&form=6&db=m Synthesis of Resveratrol Derivatives and In Vitro Screening for Potential Cancer Chemopreventive Activities. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27164411&form=6&db=m Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27173352&form=6&db=m Functional polymorphisms of the cyclooxygenase-2 gene and prognosis of hepatocellular carcinoma - a cohort study in Chinese people. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27186121&form=6&db=m Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232941&form=6&db=m JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270654&form=6&db=m Crosstalk between osteoprotegerin (OPG), fatty acid synthase (FASN) and, cycloxygenase-2 (COX-2) in breast cancer: implications in carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314294&form=6&db=m Clinical and prognosis relevance of COX-2 expression in Tunisian patients with primary gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27348052&form=6&db=m Chemopreventive effect of Toona sinensis leaf extract on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch squamous cell carcinogenesis. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27381829&form=6&db=m K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446381&form=6&db=m Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27530656&form=6&db=m Celecoxib for the Prevention of Colorectal Adenomas: Results of a Suspended Randomized Controlled Trial. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27566583&form=6&db=m The ?-3 polyunsaturated fatty acids prevented colitis-associated carcinogenesis through blocking dissociation of ?-catenin complex, inhibiting COX-2 through repressing NF-?B, and inducing 15-prostaglandin dehydrogenase. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27608907&form=6&db=m Study to elucidate molecular mechanism behind zinc chemo-preventive role during lung carcinogenesis. ongoing research,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27677075&form=6&db=m Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27695503&form=6&db=m Prognostic significance of cyclooxygenase-2 expression in patients with hepatocellular carcinoma: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27698799&form=6&db=m Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713364&form=6&db=m Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27729235&form=6&db=m The dark side of "the force" - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27750207&form=6&db=m Free radical scavenging and COX-2 inhibition by simple colon metabolites of polyphenols: A theoretical approach. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27810226&form=6&db=m The Role of Cyclooxygenase-2 in Colorectal Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27854106&form=6&db=m Expression of cyclooxygenase-2 has no impact on survival in adenocarcinoma of the esophagogastric junction but is associated with favourable clinicopathologic features. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27982164&form=6&db=m Immunohistochemical angiogenic biomarkers in hepatocellular carcinoma and cirrhosis: correlation with pathological features. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053596&form=6&db=m Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28139830&form=6&db=m Low-Dose Aspirin Acetylates Cyclooxygenase-1 in Human Colorectal Mucosa: Implications for the Chemoprevention of Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28192229&form=6&db=m HNE as an inducer of COX-2. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28239316&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase as a marker in colon carcinogenesis: analysis of the prostaglandin pathway in human colonic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400769&form=6&db=m Role of Modulator of Inflammation Cyclooxygenase-2 in Gammaherpesvirus Mediated Tumorigenesis. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28413655&form=6&db=m Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28452959&form=6&db=m Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-?B and Nrf2 Signaling Pathways. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28467670&form=6&db=m High COX-2 expression in canine mast cell tumours is associated with proliferation, angiogenesis and decreased overall survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28611510&form=6&db=m Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28611669&form=6&db=m CD24 Expression Is Increased in 5-Fluorouracil-Treated Esophageal Adenocarcinoma Cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28701863&form=6&db=m Inhibition of hypoxia-induced cyclooxygenase-2 by Korean Red Ginseng is dependent on peroxisome proliferator-activated receptor gamma. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28729694&form=6&db=m Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc (Min/+) mouse model of intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789345&form=6&db=m Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28815606&form=6&db=m Prospective study of urinary prostaglandin E2 metabolite and pancreatic cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28833615&form=6&db=m Participation of cyclooxygenase-2 in lip carcinogenesis. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28852270&form=6&db=m The Role of Proinflammatory Pathways in the Pathogenesis of Colitis-Associated Colorectal Cancer. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927131&form=6&db=m Protein expression of Fragile Histidine Triad and cyclooxgenase-2 in serrated neoplasia of the colorectum. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28940183&form=6&db=m An increased CD25-positive intestinal regulatory T-lymphocyte population is dependent on Cox-2 activity in the Apc (Min/+) model. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28948903&form=6&db=m Pilot study: duodenal MDR1 and COX2 gene expression in cats with inflammatory bowel disease and low-grade alimentary lymphoma. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29028945&form=6&db=m Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29049411&form=6&db=m XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254791&form=6&db=m Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29263155&form=6&db=m Molecular Predicators of Duodenal Familial Adenomatous Polyposis Chemoprevention: Do Chemopreventive Drugs Hit Their Presumed Molecular Targets? therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29306248&form=6&db=m Cyclooxygenase-2 (COX-2) gene polymorphism in patients with differentiated thyroid carcinomas in the Turkish population diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321183&form=6&db=m causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29351079&form=6&db=m Syphacia muris infection in rats attenuates colorectal carcinogenesis through oxidative stress and gene expression alterations. Implications for modulatory effects by Bryostatin-1. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29404887&form=6&db=m MicroRNA-101 inhibits angiogenesis via COX-2 in endometrial carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29420225&form=6&db=m Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29505957&form=6&db=m COX-2 Forms Regulatory Loop with YAP to Promote Proliferation and Tumorigenesis of Hepatocellular Carcinoma Cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29556059&form=6&db=m Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29689378&form=6&db=m In utero and lactational exposure of DEHP increases the susceptibility of prostate carcinogenesis in male offspring through PSCA hypomethylation. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29725404&form=6&db=m Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858741&form=6&db=m Eicosanoid signaling in carcinogenesis of colorectal cancer. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29904102&form=6&db=m Targeting PRPK and TOPK for skin cancer prevention and therapy. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29936588&form=6&db=m Eicosanoids and HB-EGF/EGFR in cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30012671&form=6&db=m A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30031652&form=6&db=m Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30051683&form=6&db=m COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30079321&form=6&db=m Quantitative analysis of COX-2 promoter methylation in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087797&form=6&db=m Evaluation of Cytotoxicity Effects of Chalcone Epoxide Analogues as a Selective COX-II Inhibitor in the Human Liver Carcinoma Cell Line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30096014&form=6&db=m Fermented Ganjangs (Soy Sauce and Sesame Sauce) Attenuates Colonic Carcinogenesis in Azoxymethane/Dextran Sodium Sulfate-Treated C57BL/6J Mice. diagnostic usage,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30106414&form=6&db=m Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients. An experience from Western Saudi Arabia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30154906&form=6&db=m The Novel Nutraceutical KJS018A Prevents Hepatocarcinogenesis Promoted by Inflammation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30170377&form=6&db=m COX-2 rs5275 and rs689466 polymorphism and risk of lung cancer: A PRISMA-compliant meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30183370&form=6&db=m Probiotics (Lactobacillus acidophilus and Lactobacillus rhamnosus GG) in Conjunction with Celecoxib (selective COX-2 inhibitor) Modulated DMH-Induced Early Experimental Colon Carcinogenesis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30269738&form=6&db=m Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT-116 cells through down-regulation of prostaglandin E2 receptor EP4. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30273050&form=6&db=m Triticum aestivum Sprouts Extract Inhibits Azoymethane (AOM)/Dextran Sodium Sulfate (DSS)-Induced Colon Carcinogenesis in Mice. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30314310&form=6&db=m Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30341914&form=6&db=m Cyclooxygenase-2 in cancer: A review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367494&form=6&db=m PROSTAGLANDIN E2 stimulates cancer-related phenotypes in prostate cancer PC3 cells through cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402808&form=6&db=m Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30480806&form=6&db=m c-Met inhibition is required for the celecoxib-attenuated stemness property of human colorectal cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30484258&form=6&db=m Pectin-encrusted gold nanocomposites containing phytic acid and jacalin: 1,2-dimethylhydrazine-induced colon carcinogenesis in Wistar rats, PI3K/Akt, COX-2, and serum metabolomics as potential targets. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30488858&form=6&db=m To evaluate immunoreactivity of cyclooxygenase-2 in cases of endometrial carcinoma and correlate it with expression of p53 and vascular endothelial growth factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580362&form=6&db=m Cyclooxygenase-2 expression in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30620132&form=6&db=m Screening and isolation of cyclooxygenase-2 inhibitors from Trifolium pratense L. via ultrafiltration, enzyme-immobilized magnetic beads, semi-preparative high-performance liquid chromatography and high-speed counter-current chromatography. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30674365&form=6&db=m Significance of immunohistochemical overexpression of cyclooxygenase-2 in overall and disease-free survival of oral squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30819896&form=6&db=m COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30843344&form=6&db=m Screening and isolation of cyclooxygenase-2 inhibitors from the stem bark of Phellodendron amurense Ruprecht by ultrafiltration with liquid chromatography and tandem mass spectrometry, and complex chromatography. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30900666&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31187468&form=6&db=m Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31203442&form=6&db=m Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31276061&form=6&db=m Significance of Cyclooxygenase-2 in Oncogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31297043&form=6&db=m Ethanol extracts of Allium sp. regulate cyclooxygenase-2 and E-cadherin expression in gastric cancer MKN74 cell line and enhance doxorubicin toxicity. ongoing research,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31310338&form=6&db=m A perspective on risk factors for esophageal adenocarcinoma: emphasis on Helicobacter pylori infection. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31325568&form=6&db=m Gene expression patterns of COX-1, COX-2 and iNOS in H. Pylori infected histopathological conditions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31506784&form=6&db=m Beta-ionone-inhibited proliferation of breast cancer cells by inhibited COX-2 activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31534346&form=6&db=m EP3 receptor antagonist L798,106 reduces proliferation and migration of SK-BR-3 breast cancer cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31585862&form=6&db=m Inflammatory markers in cancer: Potential resources. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31617517&form=6&db=m Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31675116&form=6&db=m Immunohistochemical detectability of cyclooxygenase-2 expression in cells of human melanocytic skin lesions: A methodological review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31747377&form=6&db=m Vietnamese coriander inhibits cell proliferation, survival and migration via suppression of Akt/mTOR pathway in oral squamous cell carcinoma. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31835815&form=6&db=m Prostaglandin E2/EP Signaling in the Tumor Microenvironment of Colorectal Cancer. therapeutic application,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31840594&form=6&db=m Anti-Tumor Mechanisms of Novel 3-(4-Substituted Benzyl)-5-Isopropil-5- Phenylhydantoin Derivatives in Human Colon Cancer Cell Line. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31994315&form=6&db=m Effects of chronic low-dose aspirin treatment on tumor prevention in three mouse models of intestinal tumorigenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32013063&form=6&db=m Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32085795&form=6&db=m Cytoplasmic PPAR? is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32104079&form=6&db=m MicroRNA-146a as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32179835&form=6&db=m Carboranyl Derivatives of Rofecoxib with Cytostatic Activity against Human Melanoma and Colon Cancer Cells. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32186945&form=6&db=m Dietary Mixed Cereal Grains Ameliorate the Azoxymethane and Dextran Sodium Sulfate-Induced Colonic Carcinogenesis in C57BL/6J Mice. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32199598&form=6&db=m Cyclooxigenase-2 and osteopontin in gastric pre-neoplastic lesions in relation to H-pylori infection and grade of inflammation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32226725&form=6&db=m Chemopreventive Effects of Licorice and Its Components. causal interaction,unassigned 2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32235869&form=6&db=m New insights into the functions of Cox-2 in skin and esophageal malignancies. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32266177&form=6&db=m Effects of Genetic and Pharmacologic Inhibition of COX-2 on Colitis-associated Carcinogenesis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32276475&form=6&db=m Genetic Deficiency of the Histamine H4-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice. causal interaction,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32319612&form=6&db=m BCL?3 promotes cyclooxygenase?2/prostaglandin E2 signalling in colorectal cancer. therapeutic application,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322056&form=6&db=m Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32363546&form=6&db=m COX-2-PGE2-EPs in gynecological cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32366935&form=6&db=m Mesenchymal PGD2 activates an ILC2-Treg axis to promote proliferation of normal and malignant HSPCs. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414698&form=6&db=m Inflammatory myofibroblastic tumor in the head and neck-a neoplasm with both tumor features and inflammation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435158&form=6&db=m Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540642&form=6&db=m Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32605038&form=6&db=m A Mechanism by which Ergosterol Inhibits the Promotion of Bladder Carcinogenesis in Rats. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32615181&form=6&db=m MicroRNAs in the anticancer effects of celecoxib: A systematic review. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640096&form=6&db=m Syringic acid modulates molecular marker-involved cell proliferation, survival, apoptosis, inflammation, and angiogenesis in DMBA-induced oral squamous cell carcinoma in Syrian hamsters. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32666185&form=6&db=m Probiotic Lactobacillus salivarius Ren prevent dimethylhydrazine-induced colorectal cancer through protein kinase B inhibition. therapeutic application,unassigned 1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32670864&form=6&db=m Administration of Metabiotics Extracted From Probiotic Lactobacillus rhamnosus MD 14 Inhibit Experimental Colorectal Carcinogenesis by Targeting Wnt/?-Catenin Pathway. unassigned -
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32758571&form=6&db=m Dihydroxystilbenes prevent azoxymethane/dextran sulfate sodium-induced colon cancer by inhibiting colon cytokines, a chemokine, and programmed cell death-1 in C57BL/6J mice. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903705&form=6&db=m Prognostic and Clinical Significance of Cyclooxygenase-2 Overexpression in Endometrial Cancer: A Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32917645&form=6&db=m Inflammation Modulation by Vitamin D and Calcium in the Morphologically Normal Colorectal Mucosa of Colorectal Adenoma Patients in a Clinical Trial. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942970&form=6&db=m Natural COX-2 inhibitors as promising anti-inflammatory agents: an update. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33033709&form=6&db=m 15-Deoxy-?12,14-prostaglandin J2 Induces Epithelial-to-mesenchymal Transition in Human Breast Cancer Cells and Promotes Fibroblast Activation. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049690&form=6&db=m Role of Cyclooxygenase-2 in colorectal cancer patients. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33057440&form=6&db=m KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi's sarcoma. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33072916&form=6&db=m Down-regulation of COX-2 activity by 1?,25(OH)2D3 is VDR dependent in endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33116404&form=6&db=m Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33132637&form=6&db=m Acetyl-11-keto-?-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147051&form=6&db=m Expression of COX-2, p16, and Ki67 in the range from normal breast tissue to breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33260755&form=6&db=m Celecoxib Loaded In-Situ Provesicular Powder and Its In-Vitro Cytotoxic Effect for Cancer Therapy: Fabrication, Characterization, Optimization and Pharmacokinetic Evaluation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33287464&form=6&db=m Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33327467&form=6&db=m Prognostic Significance of COX-2 Overexpression in BRAF-Mutated Middle Eastern Papillary Thyroid Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33429006&form=6&db=m COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33440718&form=6&db=m Genetic Variations in Prostaglandin E2 Pathway Identified as Susceptibility Biomarkers for Gastric Cancer in an Intermediate Risk European Country. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33588911&form=6&db=m Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660801&form=6&db=m Curcumin-Celecoxib: a synergistic and rationale combination chemotherapy for breast cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33686969&form=6&db=m Celecoxib alleviates zinc deficiency-promoted colon tumorigenesis through suppressing inflammation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33688233&form=6&db=m High Expression of COX-2 Associated with the Depth of Invasion on Acral Melanoma by Increasing TGF-?1. causal interaction,unassigned 4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33802010&form=6&db=m Combined COX-2/PPAR? Expression as Independent Negative Prognosticator for Vulvar Cancer Patients. causal interaction,unassigned 3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33972599&form=6&db=m Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34169083&form=6&db=m Development of PET Radioligands Targeting COX-2 for Colorectal Cancer Staging, a Review of in vitro and Preclinical Imaging Studies. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34254099&form=6&db=m Synthesis, characterization, and cellular investigations of porphyrin- and chlorin-indomethacin conjugates for photodynamic therapy of cancer. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34366627&form=6&db=m Genetic variant of cyclooxygenase-2 in gastric cancer: More inflammation and susceptibility. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34398475&form=6&db=m Cyclooxygenase-2 protein expression modulates cell proliferation and apoptosis in solid ameloblastoma and odontogenic keratocyst. An immunohistochemical study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34436652&form=6&db=m Diclofenac down-regulates COX-2 induced expression of CD44 and ICAM-1 in human HT29 colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34466408&form=6&db=m High Immunoexpression of COX-2 as a Metastatic Risk Factor in ccRCC without PD-L1 Involvement. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34543639&form=6&db=m Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA). causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872316&form=6&db=m Expression of cyclo-oxygenase-2 in gastrointestinal carcinoid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17700013&form=6&db=m An evaluation of cyclooxygenase-2 as a prognostic biomarker in mid-gut carcinoid tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,2
1.14.99.1 Carcinoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098866&form=6&db=m Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=526539&form=6&db=m Prostaglandins in human breast cancer. Identification of a cytosolic prostaglandin-9-keto-reductase activity. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1571128&form=6&db=m Administration of a prostaglandin synthetase inhibitor associated with an increased immune cell infiltrate in squamous cell carcinoma of the head and neck. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1902395&form=6&db=m Effects of the prostaglandin synthetase inhibitor indomethacin on tumorigenesis, tumor proliferation, cell kinetics, and receptor contents of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in Sprague-Dawley rats fed a high- or low-fat diet. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1917383&form=6&db=m Thromboxane production by platelets during tumor cell-induced platelet activation. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2937933&form=6&db=m Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma. diagnostic usage,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3089171&form=6&db=m [Anti-cancer treatment with prostaglandin synthetase inhibitor in animal models] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3111384&form=6&db=m [Inhibition of the growth of a murine transplantable tumor, colon 26, by the prostaglandin synthetase inhibitor, indomethacin] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3409218&form=6&db=m Profiles of prostaglandin biosynthesis in sixteen established cell lines derived from human lung, colon, prostate, and ovarian tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3926304&form=6&db=m Prostaglandin and thromboxane synthesis by Lewis lung carcinoma during growth. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6771779&form=6&db=m Analysis by high performance liquid chromatography of cyclooxygenase products of arachidonic acid metabolism in plasma of rabbits bearing the VX2 carcinoma. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7646853&form=6&db=m Inhibition of growth of a murine squamous cell carcinoma by a cyclooxygenase inhibitor increases leukotriene B4 production. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7818763&form=6&db=m Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7926468&form=6&db=m Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8048688&form=6&db=m [The characteristics of prostaglandin E synthesis in epithelial ovarian tumors] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8065730&form=6&db=m Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137463&form=6&db=m Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapies. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8275495&form=6&db=m Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612694&form=6&db=m Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8634343&form=6&db=m Arachidonic acid metabolism and cell proliferation in rat mammary carcinoma cells treated with indomethacin. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9102213&form=6&db=m Expression of cyclooxygenase-2 in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9253772&form=6&db=m [Multiple roles of inducible cyclooxygenase-2 and its selective inhibitors] therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9321948&form=6&db=m Up-regulation of cyclooxygenase-2 by product-prostaglandin E2. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9464506&form=6&db=m Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547657&form=6&db=m Tumor infiltrating lymphocytes in squamous cell carcinoma of the head and neck: mechanisms of enhancement using prostaglandin synthetase inhibitors. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9561163&form=6&db=m Heterogeneous distribution of COX-2 over-expression in human colon carcinoma cells. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9630216&form=6&db=m Cyclooxygenase regulates angiogenesis induced by colon cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635856&form=6&db=m COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679948&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679967&form=6&db=m Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on the development of rat urinary bladder carcinomas initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731479&form=6&db=m Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765305&form=6&db=m Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766436&form=6&db=m Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9809985&form=6&db=m Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823297&form=6&db=m Expression of cyclooxygenase-2 in human lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846504&form=6&db=m Expression of cyclooxygenase-2 protein in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872492&form=6&db=m Prostaglandins in the stomach: an update. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888205&form=6&db=m Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892207&form=6&db=m Cyclooxygenase-2 expression in human esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022645&form=6&db=m Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10069452&form=6&db=m Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10070952&form=6&db=m Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10216286&form=6&db=m Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10225537&form=6&db=m Specific COX-2 inhibitors in arthritis, oncology, and beyond: where is the science headed? causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10226539&form=6&db=m Expression of cyclooxygenase-2 in human squamous cell carcinoma of the esophagus; an immunohistochemical survey. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398082&form=6&db=m Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417761&form=6&db=m Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10471521&form=6&db=m Coordinate up-regulation of low-density lipoprotein receptor and cyclo-oxygenase-2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473081&form=6&db=m Overexpression of cyclooxygenase-2 in carcinoma of the pancreas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485483&form=6&db=m Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515422&form=6&db=m Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582676&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10590224&form=6&db=m Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10595745&form=6&db=m A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597402&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10605031&form=6&db=m Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10607736&form=6&db=m A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632332&form=6&db=m Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10648462&form=6&db=m Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668483&form=6&db=m Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678579&form=6&db=m Molecular pathology of cyclooxygenase-2 in neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10690533&form=6&db=m Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10713711&form=6&db=m Lipopolysaccharide increases cyclo-oxygenase-2 expression in a colon carcinoma cell line through nuclear factor-kappa B activation. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10753183&form=6&db=m High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10753955&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778945&form=6&db=m Up-regulation of cyclooxygenase-2 in squamous carcinogenesis of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10797271&form=6&db=m Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10797288&form=6&db=m Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: evidence for growth suppression by inhibiting COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803639&form=6&db=m Expression of cyclooxygenase-2 in transitional cell carcinoma of the urinary bladder in dogs. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10833474&form=6&db=m Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10841517&form=6&db=m Host cyclooxygenase-2 modulates carcinoma growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861445&form=6&db=m Increased levels of promutagenic etheno-DNA adducts in colonic polyps of FAP patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873095&form=6&db=m Cyclooxygenase-2 expression is up-regulated in transitional cell carcinoma and its preneoplastic lesions in the human urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873107&form=6&db=m Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10880372&form=6&db=m Enhanced expression of cyclooxygenase-2 in high grade human transitional cell bladder carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10911914&form=6&db=m Translational studies on Cox-2 inhibitors in the prevention and treatment of colon cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10928984&form=6&db=m Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL-6: a general role for inflammation? causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10930401&form=6&db=m Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10931458&form=6&db=m Expression of cyclooxygenase-2 in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10993880&form=6&db=m Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11011115&form=6&db=m Chemoprevention by nimesulide, a selective cyclooxygenase-2 inhibitor, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis in rats. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11018637&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in the human prostate. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11023534&form=6&db=m Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11052981&form=6&db=m Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11114729&form=6&db=m IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135226&form=6&db=m COX-2 is expressed in human pulmonary, colonic, and mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11140899&form=6&db=m Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156228&form=6&db=m Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156258&form=6&db=m Correspondence re: M. Kondo et al., Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin. Cancer Res., 5: 4005-4012, 1999. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159736&form=6&db=m Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159881&form=6&db=m Colonic luminal contents induce cyclooxygenase 2 transcription in human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11180079&form=6&db=m Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192946&form=6&db=m Helicobacter pylori, gastrin and cyclooxygenases in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196178&form=6&db=m Expression of cyclooxygenase 2 in human malignant melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11199159&form=6&db=m Expression of cyclooxygenase-2 in canine renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11207687&form=6&db=m Bowen's disease (squamous cell carcinoma in situ) in immunosuppressed patients treated with imiquimod 5% cream and a cox inhibitor, sulindac: potential applications for this combination of immunotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11234900&form=6&db=m Cyclooxygenase-2 is overexpressed in human cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238034&form=6&db=m Expression of cyclooxygenase-2 in human transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238189&form=6&db=m Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11239499&form=6&db=m Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11241241&form=6&db=m Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245450&form=6&db=m Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11286825&form=6&db=m Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11289153&form=6&db=m Differential expression of cyclooxygenase-2 and its regulation by tumor necrosis factor-alpha in normal and malignant prostate cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297248&form=6&db=m Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301836&form=6&db=m COX-2 inhibition in clinical cancer prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11307497&form=6&db=m [Cyclooxygenases] causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310210&form=6&db=m Interferon-alpha inhibits cyclooxygenase-1 and stimulates cyclooxygenase-2 expression in bladder cancer cells in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11329780&form=6&db=m [Development of new treatment modalities for advanced head and neck carcinomas] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342898&form=6&db=m Expression of cyclooxygenase-2 in patients with bladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11344234&form=6&db=m Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11346869&form=6&db=m Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375952&form=6&db=m Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11381142&form=6&db=m Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389100&form=6&db=m Transcriptional silencing of Cyclooxygenase-2 by hyper-methylation of the 5' CpG island in human gastric carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401676&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in skin cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11407522&form=6&db=m Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11410611&form=6&db=m Expression of cyclo-oxygenase-2 in naturally occurring squamous cell carcinomas in dogs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11443626&form=6&db=m Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448905&form=6&db=m Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11481417&form=6&db=m Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines. therapeutic application,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11494140&form=6&db=m Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11496309&form=6&db=m Cyclooxygenase-2 expression in an adenoid cystic carcinoma of the uterine cervix. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11571629&form=6&db=m Alterations in lipoxygenase and cyclooxygenase-2 catalytic activity and mRNA expression in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584358&form=6&db=m Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11586093&form=6&db=m Elevated COX-2 expression in cervical carcinoma: reduced cause-specific survival and pelvic control. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11586095&form=6&db=m Characterization of the effects of antiangiogenic agents on tumor pathophysiology. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11587608&form=6&db=m Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor delta with head and neck squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605016&form=6&db=m Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11606854&form=6&db=m Interaction between cyclooxygenase-2 and inducible nitric oxide synthase in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11668514&form=6&db=m Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687951&form=6&db=m The growth of malignant keratinocytes depends on signaling through the PGE(2) receptor EP1. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687954&form=6&db=m A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11688844&form=6&db=m Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745442&form=6&db=m Mn-SOD antisense upregulates in vivo apoptosis of squamous cell carcinoma cells by anticancer drugs and gamma-rays regulating expression of the BCL-2 family proteins, COX-2 and p21. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745483&form=6&db=m Constitutive expression of the cyclooxygenase-2 gene in T-cell lines infected with human T cell leukemia virus type I. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751373&form=6&db=m Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781662&form=6&db=m Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11783060&form=6&db=m [A study on cyclooxygenase-2 protein expression in esophageal carcinoma and premalignant lesions] causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788675&form=6&db=m Cyclooxygenase-2 expression in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11793368&form=6&db=m Cyclooxygenase-2 expression during carcinogenesis in the human stomach. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11801560&form=6&db=m Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian carcinoma cell lines: preclinical evaluation of NSAIDs as chemopreventive agents. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809678&form=6&db=m Effects of the cyclooxygenase inhibitor, piroxicam, on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809691&form=6&db=m Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11810043&form=6&db=m Expression of cyclooxygenase-2 is associated with carcinogenesis of the lower part of thoracic esophageal squamous cell carcinoma and p53 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819707&form=6&db=m Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection, histological types and staging. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11823979&form=6&db=m Overexpression of cyclo-oxygenase 2 in squamous cell carcinoma of the hypopharynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827414&form=6&db=m Expression of cyclooxygenase-1 and -2 in urinary bladder carcinomas in vivo and in vitro and prostaglandin E2 synthesis in cultured bladder cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836568&form=6&db=m Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11851614&form=6&db=m Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11876163&form=6&db=m COX-2 specific inhibitor, NS-398, increases macrophage migration inhibitory factor expression and induces neuroendocrine differentiation in C4-2b prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11881728&form=6&db=m Increased expression of cyclooxygenase-2 in human salivary gland tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11888937&form=6&db=m Cyclooxygenase-2 activity altered the cell-surface carbohydrate antigens on colon cancer cells and enhanced liver metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11889377&form=6&db=m Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891188&form=6&db=m Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11911489&form=6&db=m Arsenite pretreatment attenuates benzo[a]pyrene cytotoxicity in a human lung adenocarcinoma cell line by decreasing cyclooxygenase-2 levels. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11917224&form=6&db=m Expression of COX-2, Ki-67, cyclin D1, and P21 in endometrial endometrioid carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920472&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and nonsmall cell lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920595&form=6&db=m Expression of cyclooxygenase-2 in the subserosal layer correlates with postsurgical prognosis of pathological tumor stage 2 carcinoma of the gallbladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11939728&form=6&db=m Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11948128&form=6&db=m Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11953864&form=6&db=m Inhibitor of cyclooxygenase-2 induces cell-cycle arrest in the epithelial cancer cell line via up-regulation of cyclin dependent kinase inhibitor p21. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11989839&form=6&db=m Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009007&form=6&db=m Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011987&form=6&db=m Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma (Review). causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12037025&form=6&db=m Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12046075&form=6&db=m Effect of nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12051953&form=6&db=m Characterization of cyclooxygenase-2 (COX-2) during tumorigenesis in human epithelial cancers: evidence for potential clinical utility of COX-2 inhibitors in epithelial cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12055587&form=6&db=m Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070598&form=6&db=m Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075734&form=6&db=m Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086403&form=6&db=m In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086405&form=6&db=m Is cyclooxygenase-2 important in skin carcinogenesis? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12111204&form=6&db=m Cyclooxygenase-2 and Bcl-2 expression in the stomach mucosa of Wistar rats exposed to Helicobacter pylori, N'-methyl- N'-nitro- N-nitrosoguanidine and bile. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124326&form=6&db=m Cyclooxygenase-2 inhibitor treatment enhances photodynamic therapy-mediated tumor response. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124799&form=6&db=m Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126310&form=6&db=m Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126507&form=6&db=m [Association between Helicobacter pylori cagA strain infection and expression of cyclooxygenase 2 in gastric carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12168930&form=6&db=m COX-2 expression in rectal carcinoma: immunohistochemical pattern and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173384&form=6&db=m Expression of cyclooxygenase-2 in primary and remnant gastric carcinoma: comparing it with p53 accumulation, Helicobacter pylori infection, and vascular endothelial growth factor expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12174888&form=6&db=m Increased cyclooxygenase-2 expression in human squamous cell carcinomas of the head and neck and inhibition of proliferation by nonsteroidal anti-inflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12181243&form=6&db=m Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196922&form=6&db=m Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12201625&form=6&db=m The mRNA expression of cyclo-oxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12201873&form=6&db=m Cyclooxygenase-2 mRNA is up-regulated in cirrhotic or chronic hepatitis liver adjacent to hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203806&form=6&db=m Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209724&form=6&db=m Cyclooxygenase-2 expression in endometrial carcinoma: correlation with clinicopathologic parameters and clinical outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209745&form=6&db=m Overexpression of cyclooxygenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12223062&form=6&db=m COX-2 - a target for preventing hepatic carcinoma? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12269772&form=6&db=m Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369871&form=6&db=m Selective cyclooxygenase-2 inhibitors and non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393863&form=6&db=m Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12408753&form=6&db=m Expression of inflammation related enzymes during experimental rat lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414664&form=6&db=m Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429306&form=6&db=m Association of cyclooxygenase-2 expression with prognosis of stage T1 grade 3 bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434411&form=6&db=m Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12440624&form=6&db=m The role of COX-2 inhibitors in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452059&form=6&db=m [A study on cyclooxygenase-2 protein expression and vasculature during experimental rat lung carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452063&form=6&db=m [Influence of selective cyclooxygenase-2 inhibitor on proliferation of human gastric cancer cells] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12459168&form=6&db=m Correlation between nitric oxide and cyclooxygenase-2 pathways in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468638&form=6&db=m Seminal plasma activates cyclooxygenase-2 and prostaglandin E2 receptor expression and signalling in cervical adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470662&form=6&db=m Cyclooxygenase-2 increased the angiogenic and metastatic potential of tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12485462&form=6&db=m Chemopreventive effect of celecoxib and expression of cyclooxygenase-1 and cyclooxygenase-2 on chemically-induced rat mammary tumours. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12487927&form=6&db=m [Relationship between cyclooxygenase-2 protein expression, prostaglandins levels and biologic behavior in ovarian carcinoma tissue] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523498&form=6&db=m The expression of cyclooxygenase-1 and -2 in proliferative endometrium and endometrial adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12526218&form=6&db=m [Expression of cyclooxygenase-2 in human transitional cell bladder carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12532441&form=6&db=m Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12542979&form=6&db=m Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible? causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576466&form=6&db=m Clinical evaluation of mitoxantrone and piroxicam in a canine model of human invasive urinary bladder carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576817&form=6&db=m Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12589035&form=6&db=m Effects of the cyclooxygenase inhibitor, piroxicam, in combination with chemotherapy on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12596063&form=6&db=m Expression of cyclo-oxygenase-2 is correlated with high intratumoral microvessel density and low apoptotic index in human esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12614262&form=6&db=m Overexpression of cyclooxygenase-2 in high-grade human transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12615701&form=6&db=m Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12618325&form=6&db=m Cyclooxygenase-2 and prostate carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622426&form=6&db=m Expression of cyclooxygenase-2 protein in colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648590&form=6&db=m High cyclooxygenase-2 expression in cervical adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664617&form=6&db=m Growth stimulation and epidermal growth factor receptor induction in cyclooxygenase-overexpressing human colon carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679908&form=6&db=m Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684668&form=6&db=m Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686777&form=6&db=m Expression of COX-2 in stomach cancers and its relation to their biological features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12708469&form=6&db=m Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713627&form=6&db=m Cyclooxygenase-2 expression in thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12717830&form=6&db=m Nimesulide inhibits proliferation via induction of apoptosis and cell cycle arrest in human gastric adenocarcinoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727848&form=6&db=m Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738712&form=6&db=m Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738729&form=6&db=m Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738747&form=6&db=m The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12740157&form=6&db=m Cyclo-oxygenase-2 (COX-2) mRNA expression correlates with progesterone receptor positivity in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12747975&form=6&db=m Cyclooxygenase-2 (COX-2) expression in high-risk premalignant oral lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12748469&form=6&db=m Expression of cyclooxygenase-2 in cervical, endometrial, and ovarian malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767095&form=6&db=m Cyclooxygenase-2 expression in human pituitary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12818365&form=6&db=m Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12819042&form=6&db=m The function of COX-2 in human ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824517&form=6&db=m Cyclooxygenase-1 and -2 expression in urothelial carcinomas of the urinary bladder in cows. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839690&form=6&db=m [Relation between COX-2 protein expression and biologic behavior of ovarian carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12845964&form=6&db=m Cyclooxygenase-2 expression correlates with nuclear p53 accumulation in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12854133&form=6&db=m Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12870656&form=6&db=m Modulation of annexin I and cyclooxygenase-2 in smokeless tobacco-induced inflammation and oral cancer. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12874003&form=6&db=m Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12875991&form=6&db=m Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883661&form=6&db=m Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883688&form=6&db=m Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12888902&form=6&db=m Apoptosis induction and enhancement of cytotoxicity of anticancer drugs by celecoxib, a selective cyclooxygenase-2 inhibitor, in human head and neck carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12893070&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in premalignant and malignant esophageal glandular and squamous lesions in Cixian, China. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12894507&form=6&db=m The effect of cyclooxygenase inhibitor diclofenac on experimental murine colon carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895344&form=6&db=m [Overexpression of COX-2 and its clinical significance in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902846&form=6&db=m Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902860&form=6&db=m COX-2 inhibitor as a radiation enhancer: new strategies for the treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902863&form=6&db=m Combination of a COX-2 inhibitor with radiotherapy or radiochemotherapy in the treatment of thoracic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902866&form=6&db=m Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12912958&form=6&db=m Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12913755&form=6&db=m Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12930427&form=6&db=m Cyclooxygenase-2 promotes angiogenesis in pTa/T1 urothelial bladder carcinoma but does not predict recurrence. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12944556&form=6&db=m Diffuse and intestinal type gastric carcinomas differ in their expression of apoptosis related proteins. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12948419&form=6&db=m [Expression and significance of cyclooxygenase-2 in human pancreatic carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949405&form=6&db=m An immunohistochemical study of cyclooxygenase-2 expression in various feline neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954496&form=6&db=m Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957358&form=6&db=m Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963227&form=6&db=m Clinicopathologic significance of cyclooxygenase-2 overexpression in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12969226&form=6&db=m Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12969784&form=6&db=m Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide. therapeutic application,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13679206&form=6&db=m Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499677&form=6&db=m A histopathologic investigation of PGE(2) pathways as predictors of proliferation and invasion in urothelial carcinomas of the bladder. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499687&form=6&db=m The expression of cyclooxygenase in transitional cell carcinoma cell lines: its correlation with tumor differentiation, invasiveness and prostanoids production. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14502644&form=6&db=m Inhibition of cutaneous ultraviolet light B-mediated inflammation and tumor formation with topical celecoxib treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14508829&form=6&db=m The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14518302&form=6&db=m [COX-2 associated loss of apoptosis activity in intestinal neoplams in Apc gene knock-out mice] causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14521730&form=6&db=m [Inhibition of angiogenesis in pancreatic carcinoma by cyclooxygenase-2 antisense oligodeoxynucleotides] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532848&form=6&db=m Cyclooxygenase-2 inhibitor NS398 enhances antitumor effect of irradiation on hormone refractory human prostate carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532971&form=6&db=m Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532998&form=6&db=m Overexpression of cyclooxygenase-2 protein and its relationship to apoptosis in cervical carcinoma treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14550281&form=6&db=m Aberrant methylation of the specific CpG island portion regulates cyclooxygenase-2 gene expression in human gastric carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552703&form=6&db=m Immune restoration in head and neck cancer patients via cyclooxygenase inhibition: an update. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14558947&form=6&db=m [Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566678&form=6&db=m Expression of cyclooxygenase-2 in primary superficial bladder cancer tissue may predict risk of its recurrence after complete transurethral resection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566822&form=6&db=m The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14568683&form=6&db=m Correlation between cyclooxygenase-2 and tumor angiogenesis in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587561&form=6&db=m Selective inhibition of cyclooxygenase 2 induces p27kip1 and skp2 in oral squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607329&form=6&db=m Enhancement of chemotherapeutic drug-induced apoptosis by a cyclooxygenase-2 inhibitor in hypopharyngeal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607721&form=6&db=m Expression of cyclooxygenase-1 and -2 in extra-hepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14616542&form=6&db=m Cyclooxygenase-2 and gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623934&form=6&db=m Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14625126&form=6&db=m Cyclooxygenase-2 expression in the endometrium at the end of 2 years' continuous combined hormone replacement therapy. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14626203&form=6&db=m Differential expression pattern of cyclooxygenase-1 and -2 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14630280&form=6&db=m NS 398 radiosensitizes an HNSCC cell line by possibly inhibiting radiation-induced expression of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633672&form=6&db=m Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633942&form=6&db=m Comparison of cyclooxygenase 2 expression in adenocarcinomas of the gastric cardia and distal oesophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14647459&form=6&db=m Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14669280&form=6&db=m Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14674624&form=6&db=m Regulation of cell growth by selective COX-2 inhibitors in oral carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14707443&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in human esophageal mucosa, dysplasia and carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14712483&form=6&db=m Significance of COX-2 expression in human renal cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716737&form=6&db=m Analysis of the inflammatory network in benign prostate hyperplasia and prostate cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716842&form=6&db=m Expression of COX-2 proteins in gastric mucosal lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717230&form=6&db=m Immunohistochemical expression of COX-2 in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719060&form=6&db=m COX-2 status in relation to tumor microvessel density and VEGF expression: analysis in ovarian carcinoma patients with low versus high survival rates. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719128&form=6&db=m Study of cyclooxygenase-2 in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729623&form=6&db=m Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751245&form=6&db=m Suppression of prostaglandin E2 receptor subtype EP2 by PPARgamma ligands inhibits human lung carcinoma cell growth. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760075&form=6&db=m Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871981&form=6&db=m Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14969817&form=6&db=m Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14976535&form=6&db=m Biological behavior of keratoacanthoma and squamous cell carcinoma: telomerase activity and COX-2 as potential markers. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14977838&form=6&db=m Synchronous coexpression of epidermal growth factor receptor and cyclooxygenase-2 in carcinomas of the uterine cervix: a potential predictor of poor survival. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981815&form=6&db=m [Expression of cyclooxygenase in bladder transitional cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14984945&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14989896&form=6&db=m [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014019&form=6&db=m Prognostic significance of cyclooxygenase-2 in oropharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15034803&form=6&db=m Eicosanoid regulation of angiogenesis in tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15040874&form=6&db=m The role of cyclooxygenase-2 inhibition for the prevention and treatment of prostate carcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15041464&form=6&db=m Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15049901&form=6&db=m Cyclooxygenase-2 expression and relationship to tumour progression in human renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067173&form=6&db=m Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15068324&form=6&db=m HER-2, EGFR, COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069531&form=6&db=m Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15084845&form=6&db=m Expression of Cox-2, CD34, Bcl-2, and p53 and survival in patients with primary peritoneal serous carcinoma and primary ovarian serous carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102519&form=6&db=m Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138613&form=6&db=m The effects of cyclooxygenase-2 inhibitors on urological cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15144801&form=6&db=m Expression of cyclooxygenase-1 and -2 in canine nasal carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145696&form=6&db=m Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151617&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151619&form=6&db=m Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15165031&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15168734&form=6&db=m Oncostatin M stimulates the detachment of a reservoir of invasive mammary carcinoma cells: role of cyclooxygenase-2. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15173710&form=6&db=m Prognostic significance of vascular endothelial growth factor and cyclooxygenase 2 expression in patients receiving preoperative chemoradiation for esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179623&form=6&db=m COX-2 inhibition and lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218294&form=6&db=m Cyclooxygenase-2 expression in chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15221958&form=6&db=m Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222037&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15230726&form=6&db=m Cyclo-oxygenase-2 expression in esophageal adenocarcinoma as a determinant of clinical outcome following esophagectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239338&form=6&db=m [Cyclooxygenase 2 inhibitors and lung carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254653&form=6&db=m NF-kappaB, macrophage migration inhibitory factor and cyclooxygenase-inhibitions as likely mechanisms behind the acetaminophen- and NSAID-prevention of the ovarian cancer. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256475&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15259059&form=6&db=m Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265936&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15266333&form=6&db=m Clinical implication of expression of cyclooxygenase-2 and peroxisome proliferator activated-receptor gamma in epithelial ovarian tumours. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15269139&form=6&db=m Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272284&form=6&db=m COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15274299&form=6&db=m PHGPx overexpression induces an increase in COX-2 activity in colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15274307&form=6&db=m Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; correlation with intratumoral microvessel density and apoptotic index. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15287038&form=6&db=m Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289320&form=6&db=m Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15299197&form=6&db=m Expression of cyclooxygenase-2 and thromboxane synthase in non-neoplastic and neoplastic thyroid lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15327557&form=6&db=m Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332534&form=6&db=m [COX and study of cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15340847&form=6&db=m Cyclooxygenase-2 and its role in colorectal cancer development. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15342458&form=6&db=m Cyclooxygenase-2 and p53 expressions in endometrial cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15347673&form=6&db=m Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15354416&form=6&db=m A selective cyclooxygenase-2 inhibitor, NS398, inhibits cell growth and induces cell cycle arrest in the G2/M phase in human esophageal squamous cell carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355919&form=6&db=m Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355926&form=6&db=m Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358635&form=6&db=m Expression of macrophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of bile acids and NSAIDs. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15363351&form=6&db=m [Relationship of cyclooxygenase 2 expression and chemotherapy response and prognosis in human ovarian carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383996&form=6&db=m [Prostate carcinoma: higher COX-2 contents in advanced tumors] causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385109&form=6&db=m Cyclooxygenase-2 expression in borderline ovarian tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386340&form=6&db=m Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resistance protein, prostaglandin E synthetase, and glutathione-S-transferase-alpha (GST)-alpha, GST-mu, and GST-pi. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15387324&form=6&db=m Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15450303&form=6&db=m Cyclooxygenase-2 parallels invasive depth and increased MVD in transitional cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15455372&form=6&db=m Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458531&form=6&db=m Nonsteroidal anti-inflammatory drug use in the prevention and treatment of squamous cell carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458769&form=6&db=m The potential role of cyclooxygenase-2 inhibitors in the treatment of experimentally-induced mammary tumour: does celecoxib enhance the anti-tumour activity of doxorubicin? causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15461861&form=6&db=m Cyclooxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465199&form=6&db=m Differential cyclooxygenase-2 expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476283&form=6&db=m Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15478052&form=6&db=m [Prognostic role and regulation of cyclooxygenase-2 (COX-2) in ovarian carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15482327&form=6&db=m Nimesulide and indomethacin induce apoptosis in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491425&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498296&form=6&db=m [The significance of the expression of cyclooxygenase-2 in bladder transitional cell carcinoma tissues] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499987&form=6&db=m [Expression of cyclooxygenase-2 and p53 and their correlation in carcinoma of larynx] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501972&form=6&db=m Concomitant overexpression of cyclooxygenase-2 in HER-2-positive on Smad4-reduced human gastric carcinomas is associated with a poor patient outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523901&form=6&db=m Sequential expression of inducible nitric oxide synthase and cyclooxygenase-2 during DMBA-induced hamster buccal pouch carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15538221&form=6&db=m Impact of cyclooxygenase-2 gene expression on tumor invasiveness in a human renal cell carcinoma cell line. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546559&form=6&db=m Synergistic effects of Cox-1 and -2 inhibition on bladder and prostate cancer in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569051&form=6&db=m Comparative analysis of COX-2, vascular endothelial growth factor and microvessel density in human renal cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569052&form=6&db=m High microvascular density is correlated with high VEGF, iNOS and COX-2 expression in penetrating growth-type early gastric carcinomas. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592025&form=6&db=m Expression of cyclooxygenase-2 and EP4 receptor in transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596182&form=6&db=m Significance of COX-2 expression in human renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15599594&form=6&db=m Expression of COX-2 and HER-2/neu and estrogen and progesterone receptor in primary squamous cell carcinomas of the endometrium. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604909&form=6&db=m Advances that are changing the diagnosis and treatment of malignant bone tumors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15607554&form=6&db=m Lower expression of cyclooxygenase-2: is it associated with the development of borderline ovarian tumors? causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622477&form=6&db=m Correlation between cyclooxygenase-2, proliferative activity, and mucin phenotype in human advanced gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622585&form=6&db=m Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625783&form=6&db=m Suppressive effects of a selective cyclooxygenase-2 inhibitor, etodolac, on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15626918&form=6&db=m Cyclooxygenase 2 expression in serous tumors of the ovary. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632146&form=6&db=m Expression and function of the nuclear factor of activated T cells in colon carcinoma cells: involvement in the regulation of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637815&form=6&db=m [Expression of cyclooxygenase-2 in ovarian carcinoma and its significance] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15642177&form=6&db=m Do early premalignant changes in normal breast epithelial cells predict cancer development? causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645119&form=6&db=m COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645120&form=6&db=m Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15649252&form=6&db=m Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model: biological impact of capsular inflammation and reduced cyclooxygenase-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659778&form=6&db=m The cyclooxygenase inhibitor flurbiprofen reduces radiation-induced angiogenic growth factor secretion of squamous cell carcinoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15660656&form=6&db=m Cyclooxygenase-2 expression in primary Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15664302&form=6&db=m Pretreatment tumor prostaglandin E2 concentration and cyclooxygenase-2 expression are not associated with the response of canine naturally occurring invasive urinary bladder cancer to cyclooxygenase inhibitor therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681840&form=6&db=m Cystic duct dilatations and proliferative epithelial lesions in mouse mammary glands upon keratin 5 promoter-driven overexpression of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15682318&form=6&db=m Expression and clinical significance of vascular endothelial growth factor, cyclooxygenase-2, and Bcl-2 in borderline ovarian tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15700850&form=6&db=m Cyclooxygenase-2 expression in uterine leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701502&form=6&db=m Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15704107&form=6&db=m Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15736413&form=6&db=m Effect of cyclooxygenase-2 antisense oligodeoxyribonucleotides in A-549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15744816&form=6&db=m Cyclooxygenase-2 and p53 expression as prognostic indicators in conventional renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15746677&form=6&db=m Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753378&form=6&db=m Transitional cell hyperplasia and carcinomas in urinary bladders of transgenic mice with keratin 5 promoter-driven cyclooxygenase-2 overexpression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754411&form=6&db=m Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756444&form=6&db=m Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767780&form=6&db=m COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15781636&form=6&db=m Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15790444&form=6&db=m The expression of cyclooxygenase-2, VEGF and PGs in CIN and cervical carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15800927&form=6&db=m E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817909&form=6&db=m High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823108&form=6&db=m Increased cyclooxygenase-2 (COX-2) and P-glycoprotein-170 (MDR1) expression is associated with chemotherapy resistance and poor prognosis. Analysis in ovarian carcinoma patients with low and high survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15825163&form=6&db=m COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15829436&form=6&db=m Down-regulation of cyclooxygenase-2 and telomerase activity by beta-lapachone in human prostate carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15835749&form=6&db=m Formulation and evaluation of aerosolized celecoxib for the treatment of lung cancer. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15838264&form=6&db=m Endothelin-1 Stimulates Cyclooxygenase-2 Expression in Ovarian Cancer Cells Through Multiple Signaling Pathways: Evidence for Involvement of Transactivation of the Epidermal Growth Factor Receptor. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15844661&form=6&db=m Cyclooxygenase-2 induction and prostaglandin E2 accumulation in squamous cell carcinoma as a consequence of epidermal growth factor receptor activation by imatinib mesylate. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15846114&form=6&db=m Rapid up-regulation of cyclooxygenase-2 by 5-fluorouracil in human solid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15855925&form=6&db=m Oncolytic adenoviral therapy in gallbladder carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856454&form=6&db=m Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15858127&form=6&db=m Cyclooxygenase 2 expression in nasopharyngeal carcinoma: immunohistochemical findings and potential implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863127&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15864753&form=6&db=m Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870865&form=6&db=m Cox-2 and Her2/neu co-expression in invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15886845&form=6&db=m [The expressions of cyclooxygenase-2 (Cox-2),VEGF in oral squamous cell carcinoma and precancerous lesions and their significances] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15897577&form=6&db=m Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899634&form=6&db=m [Cyclooxygenase 2 inhibitors and lung carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15913419&form=6&db=m Immunohistochemical expression of cyclooxygenase 2 in follicular carcinomas of the thyroid. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15920536&form=6&db=m Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15934305&form=6&db=m Celecoxib inhibits proliferation and induces apoptosis via cyclooxygenase-2 pathway in human pancreatic carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15936552&form=6&db=m Coexpression of cyclooxygenase-2 and thymidine phosphorylase as a prognostic indicator in patients with FIGO stage IIB squamous cell carcinoma of uterine cervix treated with radiotherapy and concurrent chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947945&form=6&db=m Cyclooxygenase-2 in normal, hyperplastic and neoplastic follicular cells of the human thyroid gland. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15948119&form=6&db=m Overexpression of laminin-5 gamma2 chain and its prognostic significance in urothelial carcinoma of urinary bladder: association with expression of cyclooxygenase 2, epidermal growth factor receptor [corrected] and human epidermal growth factor receptor [corrected] 2. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15958546&form=6&db=m Coexpression of cyclooxygenases (COX-1, COX-2) and vascular endothelial growth factors (VEGF-A, VEGF-C) in esophageal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15968728&form=6&db=m Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15978332&form=6&db=m Prognostic role of cyclooxygenase-2 expression in esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15991524&form=6&db=m Expression of cyclooxygenase-2 in endometrial adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15993594&form=6&db=m In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000951&form=6&db=m Chemosensitization of pancreatic carcinoma cells to enhance T cell-mediated cytotoxicity induced by tumor lysate-pulsed dendritic cells. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16027288&form=6&db=m A replication-selective adenoviral vector for head and neck cancers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16035618&form=6&db=m Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16044407&form=6&db=m Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16046401&form=6&db=m T-oligo treatment decreases constitutive and UVB-induced COX-2 levels through p53- and NFkappaB-dependent repression of the COX-2 promoter. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16049281&form=6&db=m Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053517&form=6&db=m Inhibitory effect of a selective cyclooxygenase inhibitor on the invasion-stimulating activity of orthotopic fibroblasts for scirrhous gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055866&form=6&db=m COX-2 expression during early lung squamous cell carcinoma oncogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080510&form=6&db=m Cyclooxygenase-2 expression in human soft-tissue sarcomas is related to epithelial differentation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080553&form=6&db=m Cyclooxygenase-2 expression in brain metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083713&form=6&db=m Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16092118&form=6&db=m Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16098373&form=6&db=m NS-398, a selective cyclooxygenase-2 inhibitor, reduces experimental bladder carcinoma outgrowth by inhibiting tumor cell proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16103460&form=6&db=m Cyclooxygenase-2 expression in FAP patients carrying germ line MYH mutations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16110762&form=6&db=m Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111807&form=6&db=m Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16116973&form=6&db=m Inhibitory effects of Celecoxib and Sc-58125 on proliferation of human carcinoma of larynx Hep-2 in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16119982&form=6&db=m Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16126263&form=6&db=m Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16132759&form=6&db=m Cyclooxygenase-2 expression increases with the stage and grade in transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16144930&form=6&db=m Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16157291&form=6&db=m Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16164044&form=6&db=m Prognostic importance of COX-2 expression in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16168844&form=6&db=m Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170027&form=6&db=m Cyclooxygenase-independent down-regulation of multidrug resistance-associated protein-1 expression by celecoxib in human lung cancer cells. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16176003&form=6&db=m [Nuclear factor kappaB/p65 and cyclooxygenase-2 expression and clinic significance in human laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16185283&form=6&db=m Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186186&form=6&db=m Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202995&form=6&db=m Cyclooxygenase-2 is over-expressed in Chinese esophageal squamous cell carcinoma, and correlated with NF-kappaB: an immunohistochemical study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16203791&form=6&db=m Radiation sensitivity of human carcinoma cells transfected with small interfering RNA targeted against cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16205694&form=6&db=m Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16218400&form=6&db=m [Relationship between cyclooxygenase (COX)-2 and malignant tumors] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219633&form=6&db=m An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16246405&form=6&db=m Prevalence and prognostic significance of COX-2 expression in stage IB cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16255988&form=6&db=m [Roles of cyclooxygenase-2 and caspase-3 expression in pathogenesis of lung carcinoma: an experiment with rats] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273222&form=6&db=m Expression of p63, COX-2, EGFR and beta-catenin in smokers and patients with squamous cell carcinoma of the head and neck reveal variations in non-neoplastic tissue and no obvious changes in smokers. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16279229&form=6&db=m [Cyclooxygenases in the skin] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16285555&form=6&db=m [Relationship between the expression of cyclooxygenase-2 and microvessel density in oral squamnous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16300728&form=6&db=m Induction of COX-2 protein expression by vanadate in A549 human lung carcinoma cell line through EGF receptor and p38 MAPK-mediated pathway. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16301573&form=6&db=m Cyclooxygenase-2 expression is associated with histologic tumor type in canine mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309227&form=6&db=m Cox-2 levels in canine mammary tumors, including inflammatory mammary carcinoma: clinicopathological features and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314343&form=6&db=m Expression of cyclooxygenase-2 and matrix metalloproteinase-9 in gastric carcinoma and its correlation with angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16319525&form=6&db=m Prostaglandin E(2) Drives Cyclooxygenase-2 Expression via Cyclic AMP Response Element Activation in Human Pancreatic Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16326073&form=6&db=m Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16329720&form=6&db=m Immunohistochemical expression of cyclooxygenase 2 in follicular carcinomas of the thyroid. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16334139&form=6&db=m Cyclooxygenase-2 protein expression in relation to apoptotic potential and its prognostic significance in bladder urothelial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337966&form=6&db=m Bile acid promotes the proliferation of squamous cell carcinoma of the esophagus, independent of its inducing COX-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352617&form=6&db=m Significance of COX-2 expression in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357153&form=6&db=m Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16362262&form=6&db=m Cyclooxygenase 1 and 2 expressions in the human thyroid gland. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16369983&form=6&db=m Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376136&form=6&db=m Amphiregulin as a tumor promoter for oral squamous cell carcinoma: involvement of cyclooxygenase 2. diagnostic usage,therapeutic application,unassigned 2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376453&form=6&db=m COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16394872&form=6&db=m Preferential expression of cyclooxygenase-2 in colonic-phenotype of gastric intestinal metaplasia: association with helicobacter pylori and gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16401921&form=6&db=m Relation between cyclooxygenase-2 expression and clinicopathologic parameters with patient prognosis in transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16422548&form=6&db=m [Effect of Kanglaite injection oncyclooxygenase activity in lung carcinoma A549 cell] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424000&form=6&db=m Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16426736&form=6&db=m Expression of COX-2 in normal and pyelonephritic kidney, renal intraepithelial neoplasia, and renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16438886&form=6&db=m [Expression of cyclooxygenase-2, hMLH1 and hMSH2 proteins, and their relationship with microsatellite instability in gastric carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16448745&form=6&db=m A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16452236&form=6&db=m The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456945&form=6&db=m Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16458424&form=6&db=m Cytoplasmic phospholipase A2 expression in human colon adenocarcinoma is correlated with cyclooxygenase-2 expression and contributes to prostaglandin E2 production. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16483484&form=6&db=m [Expression of vascular endothelial growth factor C and cyclooxygenase-2 in non-small-cell lung carcinoma and their clinical significance.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489065&form=6&db=m PDLIM4 Repression by Hypermethylation as a Potential Biomarker for Prostate Cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489179&form=6&db=m COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16494037&form=6&db=m [The expressiong of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507394&form=6&db=m Cyclooxygenase-2 expression is associated with VEGF-C and lymph node metastases in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16515599&form=6&db=m Expression of cyclooxygenase-2 in epithelial ovarian tumors and its relation to vascular endothelial growth factor and p53 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16519157&form=6&db=m [Expression and implication of cyclooxygenase-2 mRNA in prostate cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525200&form=6&db=m Anti-angiogenesis therapy in pancreatic carcinoma. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525617&form=6&db=m [The antimicrobial effects of chitosans on oral pathogenic microbes in vitro.] ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16528365&form=6&db=m Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16538539&form=6&db=m COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic molecular markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16543248&form=6&db=m Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16543392&form=6&db=m Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552960&form=6&db=m [Ease-2 and inducible nitric oxide synthase in tongue hyperplasia and tongue squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16572897&form=6&db=m P53, COX-2, iNOS protein expression changes and their relationship with anti-oxidant enzymes in surgically and multi-modality treated esophageal carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16573762&form=6&db=m Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16580341&form=6&db=m Cyclooxygenase-2, angiogenesis, tumor cell proliferation, P-glycoprotein in advanced ovarian serous carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16601291&form=6&db=m Peroxisome proliferator-activated receptor {gamma} in human breast carcinoma: a modulator of estrogenic actions. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16612714&form=6&db=m COX-2 and preoperative CA-125 level are strongly correlated with survival and clinical responsiveness to chemotherapy in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618778&form=6&db=m Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model. diagnostic usage,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16681724&form=6&db=m Expression of cyclooxygenase-2 and inducible nitric oxide synthase in ovarian surface epithelial carcinomas: is there any correlation with angiogenesis or clinicopathologic parameters? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16682957&form=6&db=m Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685147&form=6&db=m Differential protein expression in the epidermis of wild-type and COX-2 transgenic mice. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16697099&form=6&db=m Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699180&form=6&db=m The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16700663&form=6&db=m Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16711020&form=6&db=m Expression of vascular endothelial growth factor and cyclooxygenase-2 in laryngeal squamous cell carcinoma and its significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16714876&form=6&db=m [Cyclo-oxygenase-2 and p53 immunoreactivity in superficial early colorectal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16720448&form=6&db=m Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16724691&form=6&db=m Association of cyclooxygenase-2 immunoreactivity with tumor recurrence and disease progression in superficial urothelial bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16730702&form=6&db=m Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16733863&form=6&db=m Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16737669&form=6&db=m Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16741061&form=6&db=m Antitumor effect of green tea polyphenol epigallocatechin-3-gallate in ovarian carcinoma cells: evidence for the endothelin-1 as a potential target. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16760127&form=6&db=m Cell density influences the effect of celecoxib in two carcinoma cell lines. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762637&form=6&db=m Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16774944&form=6&db=m Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16799479&form=6&db=m Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16803521&form=6&db=m COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818639&form=6&db=m Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818642&form=6&db=m Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16838111&form=6&db=m COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic for molecular markers. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865247&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the oral cavity and pharynx: association to p53 and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16906389&form=6&db=m COX-2 expression of ampullary carcinoma: correlation with different histotypes and clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16908593&form=6&db=m Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16909108&form=6&db=m Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16938519&form=6&db=m The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16952367&form=6&db=m COX-1 and COX-2 Expression in Feline Oral Squamous Cell Carcinoma. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16956712&form=6&db=m Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16964399&form=6&db=m Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966444&form=6&db=m Transitional Cell Carcinoma in Fishing Cats (Prionailurus viverrinus): Pathology and Expression of Cyclooxygenase-1, -2, and p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979845&form=6&db=m Cyclooxygenase-2 impairs treatment effects of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980601&form=6&db=m Temozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984531&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16995982&form=6&db=m [A relationship between cyclooxygenase-2 expression and tumor angiogenesis in experimental rat liver carcinogenesis.] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016639&form=6&db=m Elevated cell migration, invasion and tumorigenicity in human KB carcinoma cells transfected with COX-2 cDNA. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17022010&form=6&db=m Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17024120&form=6&db=m The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17037745&form=6&db=m [Effects of nonsteroidal anti-inflammatory drug celecoxib on expression of cyclooxygenase-2 (COX-2) in ovarian carcinoma cell] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17040897&form=6&db=m Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049779&form=6&db=m Increased expression of cyclooxygenase-2 and Ki-67 are associated with malignant transformation of pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056201&form=6&db=m A prospective phase I-II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062337&form=6&db=m [Association of abnormal cyclooxygenase-2 gene expression with colorectal carcinoma metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17067555&form=6&db=m Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17096355&form=6&db=m Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17122632&form=6&db=m An inverse relation between COX-2 and E-cadherin expression correlates with aggressive histologic features in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17128412&form=6&db=m Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17142201&form=6&db=m Prognostic factors and COX-2 expression in advanced stage esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17177652&form=6&db=m Cyclooxygenase-2 expression determines neo-angiogenesis in gallbladder carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178865&form=6&db=m RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17179688&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in thyroid neoplasms and their clinicopathological correlation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17189670&form=6&db=m Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17192687&form=6&db=m Expression of cyclooxygenase-2 and 12-lipoxygenase in human breast cancer and their relationship with HER-2/neu and hormonal receptors: impact on prognosis and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17199422&form=6&db=m Expression of cyclooxygenase-1 and -2 in naturally occurring squamous cell carcinomas in horses. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17207548&form=6&db=m Inhibition of cyclooxygenase-2 activity by celecoxib does not lead to radiosensitization of human prostate cancer cells in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220580&form=6&db=m Cyclo-oxygenase-2 over-expression is associated with human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237224&form=6&db=m Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17264535&form=6&db=m Coordinated upregulation of COX-2 and NF-kappaB is a steady feature of laryngeal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17265445&form=6&db=m Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17269882&form=6&db=m Immunohistochemical evaluation of cyclooxygenase expression in corneal squamous cell carcinoma in horses. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17284111&form=6&db=m Prognostic significance of CD44, platelet-derived growth factor receptor alpha, and cyclooxygenase 2 expression in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17288873&form=6&db=m Cyclooxygenase-2: a novel target in human solid tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291249&form=6&db=m Cyclooxygenase-2 expression in cervical intraepithelial neoplasia III and squamous cell cervical carcinoma, and its correlation with clinicopathologic variables. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17296438&form=6&db=m Expression of cyclooxygenase-2 in normal urothelium, and superficial and advanced transitional cell carcinoma of bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17307204&form=6&db=m Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17316722&form=6&db=m Expression of cyclooxygenase-2, P-glycoprotein and multi-drug resistance-associated protein in canine transitional cell carcinoma. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17343986&form=6&db=m Novel therapeutic approaches in the treatment of advanced pancreatic carcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17365836&form=6&db=m Expression of 15-hydroxyprostaglandin dehydrogenase, a COX-2 antagonist and tumour suppressor, is not altered in gastric carcinomas. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17383864&form=6&db=m Study of feline oral squamous cell carcinoma: potential target for cyclooxygenase inhibitor treatment. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384145&form=6&db=m EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17387473&form=6&db=m Immune restoration in head and neck cancer patients after in vivo COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404027&form=6&db=m Increased cyclooxygenase-2 expression associated with inflammatory cellular infiltration in elderly patients with vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17416236&form=6&db=m Expression of Cox-1 and Cox-2 in canine mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17427971&form=6&db=m Prognostic significance of cyclooxygenase-2 and DNA topoisomerase IIalpha expression in oral carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17448140&form=6&db=m Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17460548&form=6&db=m Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17497299&form=6&db=m Expression of p63 and cyclooxygenase-2 and their correlation in skin tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504996&form=6&db=m Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17505004&form=6&db=m Enhancement of docetaxel-induced cytotoxicity by blocking epidermal growth factor receptor and cyclooxygenase-2 pathways in squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17517527&form=6&db=m Expression of cyclooxygenase-2 in canine nasal carcinomas. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17523957&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17546626&form=6&db=m The cyclooxygenase-2-mediated prostaglandin signaling is causally related to epithelial carcinogenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17549374&form=6&db=m VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17553653&form=6&db=m Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560634&form=6&db=m The role of angiogenesis and COX-2 expression in the evolution of vulvar lichen sclerosus to squamous cell carcinoma of the vulva. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17575102&form=6&db=m Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17578436&form=6&db=m Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581403&form=6&db=m Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581404&form=6&db=m Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17591056&form=6&db=m Clinicopathologic significance of expression of cyclooxygenase-2 in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609359&form=6&db=m Cyclooxygenase-2 immunoreactivity in equine ocular squamous-cell carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17630920&form=6&db=m Nicotine, lung and cancer. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645771&form=6&db=m Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid hormone-related protein in colon 26 carcinoma. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17672932&form=6&db=m [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17687613&form=6&db=m Prognostic significance of VEGF expression in correlation with COX-2, microvessel density, and clinicopathological characteristics in human gastric carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17708399&form=6&db=m Regulation of COX-2 expression in canine prostate carcinoma: increased COX-2 expression is not related to inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17711445&form=6&db=m Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17721268&form=6&db=m COX-2 expression in invasive breast cancer: correlation with prognostic parameters and outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875728&form=6&db=m Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17876541&form=6&db=m Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17888194&form=6&db=m Expression of cyclooxygenase-2, vascular endothelial growth factor and matrix metalloproteinase-2 in patients with primary laryngeal carcinoma: a tissue microarray study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17899436&form=6&db=m Cyclooxygenase-2 expression: does it have a probable role in tumorigenesis mechanisms of renal cell carcinoma? diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17950526&form=6&db=m Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor (IGF-IR) system. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17955050&form=6&db=m Cyclooxygenase-2 overexpression abrogates the antiproliferative effects of TGF-beta. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974958&form=6&db=m Inhibition of Cyclooxygenase-2 Suppresses Lymph Node Metastasis via Reduction of Lymphangiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17985342&form=6&db=m Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996482&form=6&db=m Expression of cyclooxygenase-2 and DNA topoisomerase II alpha in precancerous and cancerous lesions of the oral mucosa. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18003891&form=6&db=m Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18007088&form=6&db=m [Mechanism and effect of selective cyclooxygenase-2 inhibitor NS-398 on human cervical carcinoma cells] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18027256&form=6&db=m Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055324&form=6&db=m Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058818&form=6&db=m The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18062281&form=6&db=m [The expression and significance of HIF-1alpha and COX-2 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18069634&form=6&db=m [Expression of COX-2 and MMP-9 in cervical carcinoma and their clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071320&form=6&db=m Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutics-induced apoptosis of human cervical carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18090132&form=6&db=m 15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094611&form=6&db=m Increased expression of cytoplasmic HuR in familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159171&form=6&db=m [COX-2 inhibitors in inflammatory bowel disease: friends or foes?] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18171606&form=6&db=m The prognostic significance of COX-2 and survivin expression in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18186150&form=6&db=m COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18197933&form=6&db=m COX-2 mRNA expression in esophageal squamous cell carcinoma (ESCC) and effect by NSAID. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202756&form=6&db=m Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202791&form=6&db=m Differential effects of selective cyclooxygenase-2 inhibitors in inhibiting proliferation and induction of apoptosis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18207033&form=6&db=m Interplay between oncoproteins and antioxidant enzymes in esophageal carcinoma treated without and with chemoradiotherapy: a prospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18225538&form=6&db=m The effects of reactive species on the tumorigenic phenotype of human head and neck squamous cell carcinoma (HNSCC) cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230181&form=6&db=m Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18234542&form=6&db=m Polymorphisms of COX-2 -765G>C and p53 codon 72 and risks of oral squamous cell carcinoma in a Taiwan population. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18237383&form=6&db=m COX-2 and PPARgamma expression are potential markers of recurrence risk in mammary duct carcinoma in-situ. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18250037&form=6&db=m [Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18266822&form=6&db=m Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18284542&form=6&db=m A study of phosphorylated ERK1/2 and COX-2 in early stage (T1-T2) oral squamous cell carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288396&form=6&db=m Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18301460&form=6&db=m Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314621&form=6&db=m [NF-kappaB subunit p65/RelA expression in ovarian carcinoma: prognostic impact and link to COX-2 overexpression] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18320325&form=6&db=m The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18323852&form=6&db=m Expression-targeted gene therapy for the treatment of transitional cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18324478&form=6&db=m VEGF, COX-2, and PCNA expression in renal cell carcinoma subtypes and their prognostic value. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18330256&form=6&db=m [Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18346877&form=6&db=m Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18356024&form=6&db=m Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18384626&form=6&db=m The relationship between the local and systemic inflammatory responses and survival in patients undergoing resection for localized renal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18399127&form=6&db=m [Study on inhibitory effects of c9, t11-conjugated linoleic acid on migration of human gastric carcinoma cell line via cyclooxygenase-2 pathway] diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18400268&form=6&db=m Correlation of COX-2 expression in stromal cells with high stage, high grade, and poor prognosis in urothelial carcinoma of upper urinary tracts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18444251&form=6&db=m Overexpression of cyclooxygenase-2 (COX-2) in the mouse urinary bladder induces the expression of immune- and cell proliferation-related genes. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446786&form=6&db=m Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18449376&form=6&db=m Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18459994&form=6&db=m Overexpression of cyclooxygenase-2 is associated with chemoradiotherapy resistance and prognosis in esophageal squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462890&form=6&db=m Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18467819&form=6&db=m Expression of cytosolic phospholipase A2 and cyclooxygenase 2 and their significance in human oral mucosae, dysplasias and squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468781&form=6&db=m Overexpression of ELAV-like Protein HuR is Associated with Increased COX-2 Expression in Atrophy, High-grade Prostatic Intraepithelial Neoplasia, and Incidental Prostate Cancer in Cystoprostatectomies. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18488158&form=6&db=m Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18536521&form=6&db=m COX-2 expression in oral lichen planus. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18564172&form=6&db=m Effects of cyclooxygenase-2 non-selective and selective inhibitors on proliferation inhibition and apoptosis induction of esophageal squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18583546&form=6&db=m E series of prostaglandin receptor 2-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18592138&form=6&db=m shRNA-targeted Cyclooxygenase (COX)-2 inhibits proliferation, reduces invasion and enhances chemosensitivity in laryngeal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18594470&form=6&db=m Cyclooxygenase-2 expression in primary and metastatic Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18609144&form=6&db=m Nine-year follow-up of a patient with attenuated familial adenomatous polyposis treated with cyclo-oxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617777&form=6&db=m Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632220&form=6&db=m COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18646190&form=6&db=m Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676844&form=6&db=m RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. diagnostic usage,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18687532&form=6&db=m The clinical application of COX-2 inhibitors may strengthen the sensitivity of renal cell carcinoma to immunotherapy. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695912&form=6&db=m Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695918&form=6&db=m In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18717758&form=6&db=m Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18751438&form=6&db=m Microvessel density (MVD) and cyclooxygenase-2 (COX-2)/ beta-catenin interaction are associated with relapse in patients with transitional carcinoma receiving adjuvant chemotherapy with paclitaxel/carboplatin: a hellenic cooperative oncology group (HECOG) study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758643&form=6&db=m Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18786206&form=6&db=m Favorable response to combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor in metastatic renal cell carcinoma: Report of three cases. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18800677&form=6&db=m [The expression of COX-2 mRNA and protein in human laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18805045&form=6&db=m Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18841789&form=6&db=m [Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18843292&form=6&db=m Tumor-Associated Macrophage-Induced Invasion and Angiogenesis of Human Basal Cell Carcinoma Cells by Cyclooxygenase-2 Induction. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18848748&form=6&db=m Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-kappaB and C/EBP as potential targets. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922923&form=6&db=m Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18923901&form=6&db=m Anticancer Effect of Celecoxib via COX-2 Dependent and Independent Mechanisms in Human Gastric Cancers Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18973191&form=6&db=m SmgGDS is up-regulated in prostate carcinoma and promotes tumour phenotypes in prostate cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18977022&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the uterine cervix is associated with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18984785&form=6&db=m Cyclooxygenase-2 expression in equine tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18988002&form=6&db=m Effects of a cyclooxygenase-1-selective inhibitor in a mouse model of ovarian cancer, administered alone or in combination with ibuprofen, a nonselective cyclooxygenase inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19000324&form=6&db=m Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015962&form=6&db=m R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017806&form=6&db=m Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021626&form=6&db=m The prognostic value of peritumoral regulatory T cells and its correlation with intratumoral cyclooxygenase-2 expression in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19046264&form=6&db=m Expression of cyclooxygenase-2 by equine ocular and adnexal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19048402&form=6&db=m Enhancement of 5-Fluorouracil Efficacy on High COX-2 Expressing HCA-7 Cells by Low Dose Indomethacin and NS-398 but not on Low COX-2 Expressing HT-29 Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056168&form=6&db=m Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19058955&form=6&db=m Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074839&form=6&db=m Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19080686&form=6&db=m [Expression of cyclooxygenase-2 in bladder transitional cell carcinoma and the significance thereof] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19082515&form=6&db=m The inhibitory effect of Gleditsia sinensis on cyclooxygenase-2 expression in human esophageal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19101649&form=6&db=m PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19102009&form=6&db=m EGFR, HER-2 and COX-2 levels in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19102503&form=6&db=m [Expressions of MMP-2 and COX-2 mRNA in bladder transitional cell carcinoma and their correlation] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19108014&form=6&db=m Decreased expression of 15-hydroxyprostaglandin dehydrogenase in gastric carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19110997&form=6&db=m A selective cyclooxygenase-2 inhibitor prevents inflammation-related squamous cell carcinogenesis of the forestomach via duodenogastric reflux in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19117991&form=6&db=m K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19118057&form=6&db=m Cyclooxygenase-2 is an independent prognostic factor in gastric carcinoma patients receiving adjuvant chemotherapy and is not associated with EBV infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19123475&form=6&db=m Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138272&form=6&db=m Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cutaneous squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148359&form=6&db=m [p53, p16 E COX-2 expression in esophageal squamous cell carcinoma and histopathological association] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19159555&form=6&db=m [Expression of cyclooxygenase-2 and urokinase plasminogen activator in gastric carcinoma and the clinical significance thereof] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19160427&form=6&db=m Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19161536&form=6&db=m Cyclooxygenase-2 expression on urothelial and inflammatory cells of cystoscopic biopsies and urine cytology as a possible predictive marker for bladder carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173907&form=6&db=m [Correlation of Helicobacter pylori infection with the expression of COX-2 and EGFR and VEGF in human gastric carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19176489&form=6&db=m Molecular Characterization of Feline COX-2 and Expression in Feline Mammary Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201881&form=6&db=m Lipopolysaccharide initiates a positive feedback of epidermal growth factor receptor signaling by prostaglandin E2 in human biliary carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203995&form=6&db=m Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19229701&form=6&db=m Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19235530&form=6&db=m Effects of a selective cyclooxygenase-1 inhibitor in SKOV-3 ovarian carcinoma xenograft-bearing mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239949&form=6&db=m Immunoexpression of cyclooxygenase-2 and p53 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19241124&form=6&db=m Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19245590&form=6&db=m Overexpression of cyclooxygenase-2 in urothelial carcinoma in conjunction with tumor-associated-macrophage infiltration, hypoxia-inducible factor-1alpha expression, and tumor angiogenesis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268443&form=6&db=m Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19278989&form=6&db=m PGE2 production in oral cancer cell lines is COX-2-dependent. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280666&form=6&db=m COX-2 polymorphisms and the risk for head and neck cancer in white patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287971&form=6&db=m Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287981&form=6&db=m Inhibitory effect of sulindac on DMBA-induced hamster cheek pouch carcinogenesis and its derived cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289254&form=6&db=m Cyclooxygenase-2/prostaglandin E(2) pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289704&form=6&db=m 7beta-hydroxycholesterol induces apoptosis and regulates cyclooxygenase 2 in head and neck squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289707&form=6&db=m Cyclooxygenase 2 promoter-based replication-selective adenoviral vector for hypopharyngeal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19300368&form=6&db=m Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in Oral Squamous Cell Carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19347867&form=6&db=m Cyclooxygenase-2 Gly587Arg variant is associated with differential enzymatic activity and risk of esophageal squamous-cell carcinoma. diagnostic usage,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351509&form=6&db=m [Expression of IGF-IR and COX-2 in renal cell carcinoma and their relationship with cell proliferation.] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19379196&form=6&db=m The effects of cyclooxygenase-2 inhibition on apoptosis and cell cycle distribution using two in vitro models of nasal squamous cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19379307&form=6&db=m Evaluation of cyclooxygenase-1 and cyclooxygenase-2 expression and the effect of cyclooxygenase inhibitors in canine prostatic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19391123&form=6&db=m DeltaNp63 isoforms differentially regulate gene expression in squamous cell carcinoma: identification of Cox-2 as a novel p63 target. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19399588&form=6&db=m COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19423214&form=6&db=m Identification of a new broad-spectrum CD8+ T cell epitope from over-expressed antigen COX-2 in esophageal carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428370&form=6&db=m Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19436636&form=6&db=m Inflammatory mammary carcinoma in 12 dogs: Clinical features, cyclooxygenase-2 expression, and response to piroxicam treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19440670&form=6&db=m The Cyclooxygenase-2 Inhibitor Nimesulide, a Nonsteroidal Analgesic, Decreases the Effect of Radiation Therapy in Head-and-Neck Cancer Cells. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19457650&form=6&db=m Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19463183&form=6&db=m Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19484991&form=6&db=m [Expression and clinical significance of hypoxia-inducible factor-1alpha and cyclooxygenase-2 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19513627&form=6&db=m Correlation and expression of COX-2 and P53 protein in basal cell carcinoma of eyelid. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19531212&form=6&db=m In situ aromatase expression in primary tumor is associated with estrogen receptor expression but is not predictive of response to endocrine therapy in advanced breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19536452&form=6&db=m Suppressive effect of sulindac on branch duct-intraductal papillary mucinous neoplasms. diagnostic usage,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19543119&form=6&db=m Bronchioloalveolar carcinoma (lepidic growth) component is a more useful prognostic factor than lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549265&form=6&db=m Meta-analysis: clinicopathological and prognostic significance of cyclooxygenase-2 expression on oesophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19559517&form=6&db=m Cox-2 expression in ovarian malignancies: a review of the clinical aspects. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19580343&form=6&db=m Immunohistochemical markers of proliferation and vascularisation in preneoplastic bronchial lesions and invasive non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19596931&form=6&db=m Discrepancies in expression and prognostic value of tumor markers in adenocarcinoma and squamous cell carcinoma in cervical cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19605908&form=6&db=m COX-2 expression in canine mammary carcinomas: correlation with angiogenesis (or microvessel density) and overall survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19606394&form=6&db=m Expression of cyclooxygenase-2, glucose transporter-1 and angiogenesis in gallbladder carcinomas and their impact on prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19622294&form=6&db=m [Short-term preoperative treatment of celecoxib, a selective cyclooxygenase-2 inhibitor, on E-cadherin expression in gastric carcinoma tissues.] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19623651&form=6&db=m Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630103&form=6&db=m Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633925&form=6&db=m Effects of the Inhibition of Cyclooxygenase-2 on Human Esophageal Cancer Cells: Inhibition of Cell Proliferation and Induction of Apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661295&form=6&db=m Cyclooxygenase 2 expression in soft tissue leiomyosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671325&form=6&db=m [Expression of cyclooxygenase-2 and relationship with mismatch repaire gene and microsatellite instability in hereditary non-polyposis colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19684042&form=6&db=m Multicenter Phase II Trial of Combination Therapy with Meloxicam, a COX-2 Inhibitor, and Natural Interferon-{alpha} for Metastatic Renal Cell Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19729335&form=6&db=m Malignant salivary gland tumors and cyclo-oxygenase-2: A histopathological and immunohistochemical analysis with implications on histogenesis. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19730383&form=6&db=m The relationship between HPV16 and expression of cyclooxygenase-2, P53 and their prognostic roles in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737986&form=6&db=m Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19752399&form=6&db=m Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-hydroxyeicosatetraenoic acid by native and aspirin-acetylated cyclooxygenase-2. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19758248&form=6&db=m Epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines is mediated through extracellular signal-regulated kinase 1/2 and p38 but is Src and nuclear factor-kappa B independent. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759871&form=6&db=m Immunohistochemical Demonstration of Membrane-bound Prostaglandin E(2) Synthase-1 in Papillary Thyroid Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19799610&form=6&db=m Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19816074&form=6&db=m The relationship between cyclooxygenase-2, CD44v6, and nm23H1 in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19821125&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19841681&form=6&db=m Decreased polyunsaturated Fatty Acid content contributes to increased survival in human colon cancer. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843689&form=6&db=m Elevated Levels of Urinary Prostaglandin E Metabolite Indicate a Poor Prognosis in Ever Smoker Head and Neck Squamous Cell Carcinoma Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19846907&form=6&db=m Cyclin-mediated G1 arrest by celecoxib differs in low-versus high-grade bladder cancer. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895739&form=6&db=m [Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19899409&form=6&db=m Cox-2 immunohistochemical expression in epithelial ovarian carcinoma and platin sensitivity. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19923064&form=6&db=m [Inhibitory effects of COX-2 inhibitor on migration of human tongue squamous cell carcinoma Tca8113 cells] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956499&form=6&db=m Co-Expression of Cox-2, C-Met and beta-catenin in Cells Forming Invasive front of Gallbladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19999807&form=6&db=m [Cyclooxygenase inhibitors in chemoprevention and treatment of esophageal squamous cell carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20021866&form=6&db=m [Expression of COX-2 and VEGF and their correlation with angiogenesis in human clear cell renal cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025478&form=6&db=m Prognostic significance of apoptotic cell death in bladder cancer: a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025602&form=6&db=m Dual EGFR and COX-2 inhibition as a novel approach to targeting head and neck squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034753&form=6&db=m Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20037297&form=6&db=m [The IL-6 and COX-2 expression related to sensitivity of chemoradiotherapy and prognosis in esophageal carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051366&form=6&db=m Translating cyclooxygenase signaling in patch heterozygote mice into a randomized clinical trial in basal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051374&form=6&db=m Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20099494&form=6&db=m Expression of cyclooxygenase-2 in ovarian serous carcinoma: correlation with angiogenesis, nm23 expression and survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20100477&form=6&db=m MiRNA-26b regulates the expression of cyclooxygenase-2 in desferrioxamine-treated CNE cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110411&form=6&db=m COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20121928&form=6&db=m c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192574&form=6&db=m Cyclooxygenase-2 Expression in Cervical Squamous Cell Carcinoma: the Significance of Expression in Neoplastic Cells within the Lymphovascular Space. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20213098&form=6&db=m Circulating cycloxygenase-2 in patients with tobacco-related intraoral squamous cell carcinoma and evaluation of its peptide inhibitors as potential antitumor agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20222044&form=6&db=m Differential effects between cyclooxygenase-2 inhibitors and siRNA on vascular endothelial growth factor production in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227160&form=6&db=m Cyclo-oxygenase type 2 is dysregulated in breast ductal carcinoma in situ and correlates with poor outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304053&form=6&db=m Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH(2))D(3)) and prostaglandin E(2) (PGE(2)) serum level in ovarian cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353702&form=6&db=m [Gastric carcinoma and chronic gastritis: epigenetic regulation of CDH1 (E-Cadherin), CDKN2A (p16INK4A), PTGS2 (COX-2) and EGFR genes through methylation] causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20364406&form=6&db=m Study on the association of COX-2 genetic polymorphisms with risk of gastric cancer in high incidence Hexi area of Gansu province in China. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20369487&form=6&db=m [Relationship of cyclooxygenase-2 and multidrug resistance associated factors to chemosensitivities in gastrointestinal carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20389170&form=6&db=m Enhancement of the sensitivity of renal cell carcinoma cells to fas-mediated cytotoxicity and apoptosis by the selective cyclooxygenase-2 inhibitor JTE-522. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20409773&form=6&db=m COX-2 is overexpressed in primary prostate cancer with metastatic potential and may predict survival. A comparison study between COX-2, TGF-beta, IL-10 and Ki67. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412400&form=6&db=m Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428812&form=6&db=m Potential of molecular targeted therapy of HER-2 and Cox-2 for invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20429377&form=6&db=m [Expression and significance of COX-2 and S-100 positive dendritic cell in laryngeal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20459551&form=6&db=m Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20514441&form=6&db=m Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519042&form=6&db=m Inhibitory effect of HuR gene small interfering RNA segment on laryngeal carcinoma Hep-2 cell growth. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20536410&form=6&db=m COX-2 expression in human breast carcinomas: correlation with clinicopathological features and prognostic molecular markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20558731&form=6&db=m Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20559705&form=6&db=m Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20573388&form=6&db=m Expression of Ki-67 and COX-2 in patients with upper urinary tract urothelial carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582552&form=6&db=m Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592893&form=6&db=m Cox-2 and IL-10 polymorphisms and association with squamous cell carcinoma of the head and neck in a Korean sample. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20606309&form=6&db=m A new cyclooxygenase-2 inhibitor, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4-dien-3-one (GL63) suppresses cyclooxygenase-2 gene expression in human lung epithelial cancer cells: coupled mRNA stabilization and posttranscriptional inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620096&form=6&db=m Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635052&form=6&db=m [Expression of NF-kappaB and COX-2 in tongue squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20640858&form=6&db=m Diagnostic utility of immunohistochemical panel in various thyroid pathologies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20645029&form=6&db=m Cyclooxygenase-2 gene and lung carcinoma risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651346&form=6&db=m COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20653782&form=6&db=m Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664981&form=6&db=m Promotion of hematogenous metastatic potentials in human KB carcinoma cells with overexpression of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20683050&form=6&db=m Prognostic evaluation of COX-2 expression in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717005&form=6&db=m Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731664&form=6&db=m Nucleotide-binding domain of phosphoglycerate kinase 1 reduces tumor growth by suppressing COX-2 expression. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20818651&form=6&db=m Molecular typing of epithelial ovarian carcinomas using inflammatory markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20827306&form=6&db=m Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor ?B Is a Steady Feature of Urinary Bladder Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20846124&form=6&db=m Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of gallbladder carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20857495&form=6&db=m Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878581&form=6&db=m [Correlation of cyclooxygenase 2 expression with microlymphatic density and its clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20951077&form=6&db=m A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960565&form=6&db=m Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20973869&form=6&db=m Phase-II trial of combination treatment of interferon-?, cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin-system inhibitor (I-CCA therapy) for advanced renal cell carcinoma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069476&form=6&db=m COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21086092&form=6&db=m Expression of C-reactive protein and cyclooxygenase enzyme-2 in clear cell renal cell carcinoma: correlation with pathological parameters in 110 patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21086572&form=6&db=m Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: a meta-analysis. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21107726&form=6&db=m Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115882&form=6&db=m Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21127751&form=6&db=m Relationship between arachidonic acid pathway and human renal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21133589&form=6&db=m Cyclooxygenase-2 expression in gastrointestinal stromal tumours. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21152137&form=6&db=m Relation of the expression of cyclooxygenase-2 in colorectal adenomas and adenocarcinomas to angiogenesis and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21157974&form=6&db=m Relationship between COX-2 and cell cycle-regulatory proteins in patients with esophageal squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21166741&form=6&db=m Promoter hypermethylation of cyclooxygenase-2 gene in esophageal squamous cell carcinoma. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21166751&form=6&db=m Improved cancer specific-survival in patients with carcinoma invading bladder muscle expressing cyclo-oxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21176579&form=6&db=m [Nimesulide induced apoptosis and inhibited metastasis of hypopharyngeal carcinoma cells]. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21195874&form=6&db=m Prognostic cell biological markers in cervical cancer patients primarily treated with (chemo)radiation: a systematic review. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21206978&form=6&db=m Heme oxygenase-1 promotes angiogenesis in urothelial carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215004&form=6&db=m [Expression of COX-2 and its prognostic significance in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21234531&form=6&db=m Celecoxib enhances radiation response of secondary bone tumors of a human non-small cell lung cancer via antiangiogenesis in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21245412&form=6&db=m Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21251407&form=6&db=m [Study of COX-2 expression and angiogenesis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21254648&form=6&db=m [Clinical significance and relationship between HIF-1alpha, COX-2, VEGF and microvessel density expression in laryngeal carcinoma]. ongoing research,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21255800&form=6&db=m Prognostic value of cyclooxygenase-2 expression in squamous cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21262157&form=6&db=m [Cyclooxygenase-2, inducible nitric oxide synthase protein expression and vasculature during experimental rat lung carcinogenesis.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21270615&form=6&db=m Clinicopathologic implications of the epidermal growth factor receptor, cyclooxygenase 2 expression, and human papillomavirus status in squamous cell carcinoma of the uterine cervix in the elderly. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21277871&form=6&db=m Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21301321&form=6&db=m The influence of cyclooxygenase-1 expression on the efficacy of cyclooxygenase-2 inhibition in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21309483&form=6&db=m Cyclooxygenase-2 and survivin in superficial urothelial carcinoma of the bladder and correlation with intratumoural microvessel density. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21340007&form=6&db=m Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21365830&form=6&db=m [Effect of cyclooxygenase-2 inhibitor on expression of matrix metalloproteinase-2 and invasion of tongue squamous cell carcinoma cell line Tca8113]. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21384343&form=6&db=m Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21403827&form=6&db=m Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424030&form=6&db=m Immunohistochemical evaluation of COX-2 expression in HPV-positive cervical squamous intraepithelial lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424032&form=6&db=m Expression of VEGF, VEGFR, EGFR, COX-2 and MVD in cervical carcinoma, in relation with the response to radio-chemotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443099&form=6&db=m Expression of COX-2, survivin in regional lymph node metastases of gastric carcinoma and the correlation with prognosis. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443112&form=6&db=m Expression characteristics of heparanase in colon carcinoma and its close relationship with cyclooxygenase-2 and angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468258&form=6&db=m VEGF as a Predictor for Response to Definitive Chemoradiotherapy and COX-2 as a Prognosticator for Survival in Esophageal Squamous Cell Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21478098&form=6&db=m Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in normal and pathological human oral mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479387&form=6&db=m Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479487&form=6&db=m Cyclooxygenase-2 expression in invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21481000&form=6&db=m Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21487892&form=6&db=m Clinical and Immunomodulatory Effects of Celecoxib Plus Interferon-Alpha in Metastatic Renal Cell Carcinoma Patients with COX-2 Tumor Immunostaining. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21507199&form=6&db=m IL-10 production in non-small cell lung carcinoma patients is regulated by ERK, P38 and COX-2. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21559762&form=6&db=m Inhibitory effect of celecoxib in lung carcinoma by regulation of cyclooxygenase-2/cytosolic phospholipase A(2) and peroxisome proliferator-activated receptor gamma. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21569199&form=6&db=m COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21572400&form=6&db=m Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21601872&form=6&db=m Immunohistochemical Detection of COX-2 in Feline and Canine Actinic Keratoses and Cutaneous Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21602450&form=6&db=m Analysis of promoters and expression-targeted gene therapy optimization based on doubling time and transfectability. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21652147&form=6&db=m Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21654686&form=6&db=m A systematic review to establish the frequency of cyclooxygenase-2 expression in normal breast epithelium, ductal carcinoma in situ, microinvasive carcinoma of the breast and invasive breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656078&form=6&db=m The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21678473&form=6&db=m Overexpression of cyclooxygenase-2 in NCI-H292 human alveolar epithelial carcinoma cells: Roles of p38 MAPK, ERK-1/2, and PI3K/PKB signaling proteins. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21713707&form=6&db=m [Expression and clinical significance of COX-2 and BCL-2 in distal transitional mucosa adjacent to rectal carcinoma]. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21762277&form=6&db=m Clinicopathological significance of cyclooxygenase-2 and cell cycle-regulatory proteins expression in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21790228&form=6&db=m Expression of miR-143 Reduces Growth and Migration of Human Bladder Carcinoma Cells by Targeting Cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21800055&form=6&db=m Cyclooxygenase-2 -765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21868314&form=6&db=m [Epidermal growth factor stimulates the proliferation of human esophageal squamous cell carcinoma HKESC-1 cells by increasing COX-2 expression]. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21909878&form=6&db=m Nitric Oxide (NO) and Cyclooxygenase-2 (COX-2) Cross-Talk in Co-Cultures of Tumor Spheroids with Normal Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21912077&form=6&db=m The angiogenic switch for vascular endothelial growth factor-A and cyclooxygenase-2 in prostate carcinoma: correlation with microvessel density, androgen receptor content and Gleason grade. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21923838&form=6&db=m DNA polymorphisms and tissue cyclooxygenase-2 expression in oral lichen planus: a case-control study. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21934214&form=6&db=m Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: a pilot study. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21962280&form=6&db=m 5-lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21985349&form=6&db=m Antitumor effects of deracoxib treatment in 26 dogs with transitional cell carcinoma of the urinary bladder. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22000259&form=6&db=m [Analysis of HIF-1? and COX-2 expression in tumor stroma and correlation with the degree of neoplasm invasiveness in laryngeal cancer--preliminary study]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002749&form=6&db=m Cyclooxygenase-2 and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038018&form=6&db=m Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038216&form=6&db=m Expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma: correlations with clinicopathologic features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22081106&form=6&db=m Cyclooxygenase-2 expression in esophageal epithelium before and after photodynamic therapy for Barrett's esophagus with high-grade dysplasia or intramucosal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22082586&form=6&db=m ?-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22088344&form=6&db=m The impact of cyclooxygenase-2 and vascular endothelial growth factor C immunoexpression on the prognosis of penile carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22147962&form=6&db=m Effects of cyclooxygenase-2 on human esophageal squamous cell carcinoma. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159575&form=6&db=m Role of COX-2 activity and CRP levels in patients with non-melanoma skin cancer. -765G>C PTGS2 polymorphism and NMSC risk. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22170686&form=6&db=m The role of COX-2/PGE(2) in gossypol-induced apoptosis of colorectal carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228906&form=6&db=m Decreased Toll-interacting protein and peroxisome proliferator-activated receptor ? are associated with increased expression of Toll-like receptors in colon carcinogenesis. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22234093&form=6&db=m A study on expression pattern of cyclooxygenase-2 in carcinoma of cervix. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22247036&form=6&db=m Cyclooxygenase-2 expression and clinical parameters in laryngeal squamous cell carcinoma, vocal fold nodule, and laryngeal atypical hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22263894&form=6&db=m Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2'-Des-methyl-sulindac Sulfide Scaffold. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22289336&form=6&db=m Cox-2 gene overexpression in ureteral stump urothelial carcinoma following nephrectomy for renal cell carcinoma: a case report. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22343740&form=6&db=m [A case of favorable response after combination treatment with interferon-? and cyclooxygenase-2 inhibitor against metastatic renal cell carcinoma]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371637&form=6&db=m Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22372762&form=6&db=m Prognostic value of apoptotic markers in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22408147&form=6&db=m Clinical features, survival times and COX-1 and COX-2 expression in cats with transitional cell carcinoma of the urinary bladder treated with meloxicam. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435505&form=6&db=m Promoter methylation regulates cigarette smoke-stimulated cyclooxygenase-2 expression in esophageal squamous cell carcinoma. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22442604&form=6&db=m Overexpression of COX-2 in oral squamous cell carcinoma patients undergoing chemoradiotherapy. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22453101&form=6&db=m Nimesulide inhibited the growth of hypopharyngeal carcinoma cells via suppressing Survivin expression. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460809&form=6&db=m High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460857&form=6&db=m Epithelial to mesenchymal transition in cutaneous squamous cell carcinoma is correlated with COX-2 expression but not with the presence of stromal macrophages or CD10-expressing cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534023&form=6&db=m Pattern of expression of cyclooxygenase-2 in malignant transformation of sinonasal inverted papilloma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22575501&form=6&db=m Heparanase and cyclooxygenase-2 gene and protein expressions during progression of oral epithelial dysplasia to carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613332&form=6&db=m [Effects of tea polyphenols on the expression of NF-?B, COX-2 and survivin in Lewis lung carcinoma xenografts in C57BL/6 mice]. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22627629&form=6&db=m The expression of p53 and COX-2 in basal cell carcinoma, squamous cell carcinoma and actinic keratosis cases. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22634839&form=6&db=m Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22665749&form=6&db=m Comparison of COX2 expression between oral squamous cell carcinoma, leukoplakia and normal mucosa. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22667343&form=6&db=m Immunohistochemical study of cyclooxygenase-2 in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22678114&form=6&db=m Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689176&form=6&db=m A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22715107&form=6&db=m Identification of novel target proteins in sebaceous gland carcinoma. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22729746&form=6&db=m Prognostic significance of cyclooxygenase-2 in cervical cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735610&form=6&db=m Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22807982&form=6&db=m Effect of the combination of a cyclooxygenase-1 selective inhibitor and taxol on proliferation, apoptosis and angiogenesis of ovarian cancer in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22818026&form=6&db=m Nuclear factor ?B and cyclooxygenase-2 immunoexpression in oral dysplasia and oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22824620&form=6&db=m Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKK?, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22887904&form=6&db=m Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22949827&form=6&db=m Effects of cyclooxygenase inhibitors in combination with taxol on expression of cyclin d1 and ki-67 in a xenograft model of ovarian carcinoma. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23028744&form=6&db=m Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23084580&form=6&db=m Expression of p27, COX-2, MLH1, and MSH2 in young patients with colon carcinoma and correlation with morphologic findings. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23095338&form=6&db=m Significance of Cyclooxygenase 2, EZH-2 Polycomb Group and p53 Expression in Actinic Keratosis and Squamous Cell Carcinomas of the Skin. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23109979&form=6&db=m Detection of Survivin and COX-2 in Thyroid Carcinoma: Anaplastic Carcinoma Shows Overexpression of Nuclear Survivin and Low COX-2 Expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23110009&form=6&db=m Cyclooxygenase-2 expression and its prognostic significance in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23126361&form=6&db=m Lower cyclooxygenase-2 expression is associated with recurrence of solitary non-muscle invasive bladder carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23135108&form=6&db=m [The influence of COX-2 depressant in angiogenesis of oral squamous cell carcinoma]. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23177619&form=6&db=m Correlation analysis of c-myc, p21(WAF/CIP1), p53, C-erbB-2 and COX-2 proteins in esophageal squamous cell carcinoma. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23179937&form=6&db=m High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23193911&form=6&db=m Antitumor properties of taxol in combination with cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian tumor growth in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23205923&form=6&db=m Randomized trial of cisplatin versus firocoxib versus cisplatin/firocoxib in dogs with transitional cell carcinoma of the urinary bladder. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23222816&form=6&db=m Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226772&form=6&db=m Vascular endothelial growth factor promotes the expression of cyclooxygenase 2 and matrix metalloproteinases in Lewis lung carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23253733&form=6&db=m Application of epidermal growth factor receptor, vascular endothelial growth factor and cyclooxygenase-2 in prognosis of esophageal carcinomas. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23261444&form=6&db=m The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23322198&form=6&db=m Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23393346&form=6&db=m COX-2 overexpression Induced by gene transfer reduces sensitivity of TE13 esophageal carcinoma cells to 5-fluorouracil and cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426606&form=6&db=m Correlation among 16 biological factors [p53, p21(waf1), MIB-1 (Ki-67), p16(INK4A), cyclin D1, E-cadherin, Bcl-2, TNF-?, NF-?B, TGF-?, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1?] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426648&form=6&db=m Effects of combining Taxol and cyclooxygenase inhibitors on the angiogenesis and apoptosis in human ovarian cancer xenografts. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23456767&form=6&db=m Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520664&form=6&db=m Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23531445&form=6&db=m Molecular Imaging of Cyclooxygenase-2 in Canine Transitional Cell Carcinomas In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23552739&form=6&db=m Evaluation of epigenetic modulation of cyclooxygenase-2 as a prognostic marker for hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23574384&form=6&db=m Celecoxib Inhibits Helicobacter pylori-induced Invasion of Gastric Cancer Cells Through an Adenine Nucleotide Translocator-Dependent Mechanism. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23580446&form=6&db=m Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675041&form=6&db=m Celecoxib Enhances the Chemotherapeutic Response of Cisplatin and TNF-? in SiHa Cells through Reactive Oxygen Species-Mediated Mitochondrial Pathway. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23679684&form=6&db=m Effects of celecoxib treatment over the AKT pathway in head and neck squamous cell carcinoma. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23687559&form=6&db=m The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23715826&form=6&db=m Androgen receptor promotes the migration and invasion of upper urinary tract urothelial carcinoma cells through the upregulation of MMP-9 and COX-2. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717003&form=6&db=m Up-regulation of cyclooxygenase 2 and matrix metalloproteinases-2 and -9 in cutaneous squamous cell carcinoma: active role of inflammation and tissue remodeling in carcinogenesis. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23790336&form=6&db=m COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23827762&form=6&db=m An apple oligogalactan suppresses endotoxin-induced cyclooxygenase-2 expression by inhibition of LPS pathways. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851751&form=6&db=m Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23879794&form=6&db=m Expression of COX-1, COX-2 and mPGES-1 in penile and preputial papillomas and squamous cell carcinomas in the horse. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23886173&form=6&db=m Overexpression of cyclooxygenase-1 correlates with poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23931237&form=6&db=m Re: cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23946803&form=6&db=m ?-linolenic acid inhibits human renal cell carcinoma cell proliferation through PPAR-? activation and COX-2 inhibition. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23974731&form=6&db=m Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23975167&form=6&db=m Potential targets for colorectal cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23978451&form=6&db=m Flaxseed enriched diet-mediated reduction in ovarian cancer severity is correlated to the reduction of prostaglandin E2 in laying hen ovaries. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24004819&form=6&db=m Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019861&form=6&db=m Expression of COX-2, CD44v6 and CD147 and Relationship with Invasion and Lymph Node Metastasis in Hypopharyngeal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24083698&form=6&db=m Cyclooxygenase-2 Expression in Urinary Bladder Transitional Cell Carcinoma and its Association with Clinicopathological Characteristics. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085777&form=6&db=m Chemoprevention of Head and Neck Cancer with Celecoxib and Erlotinib: Results of a Phase 1b and Pharmacokinetic Study. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24284961&form=6&db=m Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24289600&form=6&db=m MicroRNA-101 inhibits cell proliferation, invasion, and promotes apoptosis by regulating cyclooxygenase-2 in Hela cervical carcinoma cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24345644&form=6&db=m COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24374907&form=6&db=m Comprehensive analysis of HPV expression in laryngeal squamous cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469308&form=6&db=m Cell-type-specific roles for COX-2 in UVB-induced skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469360&form=6&db=m Association between cyclooxygenase-2 gene polymorphisms and head and neck squamous cell carcinoma risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24513875&form=6&db=m Hippocampal dysfunctions in tumor-bearing mice. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24518705&form=6&db=m Role of cyclooxygenase-2, ezrin and matrix metalloproteinase-9 as predictive markers for recurrence of basal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535229&form=6&db=m A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24631063&form=6&db=m Piroxicam inhibits Masitinib-induced cyclooxygenase 2 expression in oral squamous cell carcinoma cells in vitro. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24641411&form=6&db=m Association of Single Nucleotide Polymorphisms in the Prostaglandin-endoperoxide Synthase 2 (PTGS2) and Phospholipase A2 Group IIA (PLA2G2A) Genes with Susceptibility to Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24677746&form=6&db=m HIF-1? and CA-IX as predictors of locoregional control for determining the optimal treatment modality for early-stage laryngeal carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24692703&form=6&db=m Endoplasmic Reticulum Stress Response as a Possible Mechanism of Cyclooxygenase-2-independent Anticancer Effect of Celecoxib. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727329&form=6&db=m Erlotinib, erlotinib-sulindac vs. placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24824420&form=6&db=m COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24887090&form=6&db=m Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24934485&form=6&db=m KRAS, EGFR, PDGFR-?, KIT and COX-2 status in carcinoma showing thymus-like elements (CASTLE). diagnostic usage,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24934992&form=6&db=m Novel pyrazoline derivatives as bi-inhibitor of COX-2 and B-Raf in treating cervical carcinoma. therapeutic application,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24999478&form=6&db=m Alterations in lipid mediated signaling and Wnt/ ? -catenin signaling in DMH induced colon cancer on supplementation of fish oil. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25004291&form=6&db=m Evaluation of P53, E-cadherin, Cox-2, and EGFR protein imunnoexpression on prognostic of resected gallbladder carcinoma. diagnostic usage,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25011213&form=6&db=m COX-2 expression pattern is related to ovarian cancer differentiation and prognosis, but is not consistent with new model of pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25023988&form=6&db=m A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25053391&form=6&db=m Modulatory effects of meloxicam on cardiotoxicity and antitumor activity of doxorubicin in mice. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25077370&form=6&db=m COX-2, p16 and Ki67 expression in DCIS, microinvasive and early invasive breast carcinoma with extensive intraductal component. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085205&form=6&db=m CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25102875&form=6&db=m [Expression and clinical significance of Cox-2 and XIAP in malignant tumors of the salivary gland]. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25142993&form=6&db=m [Relationship between cyclooxygenase-2 in nasopharyngeal carcinoma and cervical lymph node metastasis]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25169079&form=6&db=m The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25172294&form=6&db=m Oesophageal squamous cell carcinoma in high-risk Chinese populations: Possible role for vascular epithelial growth factor A. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25198789&form=6&db=m Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25225463&form=6&db=m Expression of epidermal growth factor receptor, p53, Bcl2, vascular endothelial growth factor, cyclooxygenase-2, cyclin D1, human epidermal receptor-2 and Ki-67: Association with clinicopathological profiles and outcomes in gallbladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25228975&form=6&db=m Cyclooxygenase 2 in gastric carcinoma is expressed in doublecortin- and CaM kinase-like-1-positive tuft cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25252849&form=6&db=m Hu-antigen receptor (HuR) and cyclooxygenase-2 (COX-2) expression in human non-small-cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25271626&form=6&db=m Prostanoid induces premetastatic niche in regional lymph nodes. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25275044&form=6&db=m The role of functional polymorphisms of cyclooxygenase 2 in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25276196&form=6&db=m Cytotoxicity of selected novel chalcone derivatives on human breast, lung and hepatic carcinoma cell lines. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25278683&form=6&db=m Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301050&form=6&db=m CXCR-4 and COX-2 Expression in Basal Cell Carcinomas and Well-Differentiated Squamous Cell Carcinomas of the Skin; Their Relationship with Tumor Invasiveness and Histological Subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25328959&form=6&db=m Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25355039&form=6&db=m Prognostic value of COX-2, P53, and EZH-2 evaluated by quantitative image analysis in premalignant and malignant breast lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25392182&form=6&db=m Difference in prognostic values of maximal standardized uptake value on fluorodeoxyglucose-positron emission tomography and cyclooxygenase-2 expression between lung adenocarcinoma and squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25395947&form=6&db=m Increased level of serum prostaglandin-2 in early stage of esophageal squamous cell carcinoma. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25405520&form=6&db=m JAK2 inhibitor blocks the inflammation and growth of esophageal squamous cell carcinoma in vitro through the JAK/STAT3 pathway. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25411520&form=6&db=m Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422234&form=6&db=m Overexpression of phospholipase A2 Group IIA in esophageal squamous cell carcinoma and association with cyclooxygenase-2 expression. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483152&form=6&db=m miR-26b is downregulated in human tongue squamous cell carcinoma and regulates cell proliferation and metastasis through a COX-2-dependent mechanism. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25575894&form=6&db=m Expression of Cyclooxygenase-2 in Squamous Cell Carcinoma and Keratoacanthoma and its Clinical Significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579548&form=6&db=m Cyclo-oxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595899&form=6&db=m Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25635769&form=6&db=m Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25703137&form=6&db=m COMBINATION OF RADIATION THERAPY AND FIROCOXIB FOR THE TREATMENT OF CANINE NASAL CARCINOMA. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25817787&form=6&db=m USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875558&form=6&db=m Coexpression of COX-2 and iNOS in Angiogenesis of Superficial Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973134&form=6&db=m Inhibition of ovarian cancer proliferation and invasion by pachymic acid. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26011146&form=6&db=m Inhibition of 11?-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26022894&form=6&db=m Comparative Expression of Apoptotic Markers in Lung Adenocarcinoma and Squamous Cell Carcinoma. diagnostic usage,therapeutic application,unassigned 1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26060153&form=6&db=m Relationship of CD95 and COX-2 in renal cell carcinomas with survival and other prognostic parameters: A tissue microarray study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26218314&form=6&db=m Expression and clinical implication of cyclooxygenase-2 and e-cadherin in oral squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26252813&form=6&db=m Retraction. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26281984&form=6&db=m Retraction Note to: Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26323923&form=6&db=m Expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in Chinese patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339385&form=6&db=m Combined use of COX-1 and VEGF immunohistochemistry refines the histopathologic prognosis of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26369479&form=6&db=m Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26423666&form=6&db=m Expression and Significance of COX-2 and Ki-67 in Hepatolithiasis with Bile Duct Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498686&form=6&db=m Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498950&form=6&db=m Minor salivary gland carcinoma: a review of 35 cases. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26556718&form=6&db=m Cyclooxygenase-2, a Potential Therapeutic Target, Is Regulated by miR-101 in Esophageal Squamous Cell Carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26568042&form=6&db=m Cyclooxygenase-2-1195G>A Polymorphism and Head and Neck Squamous Cell Carcinoma Susceptibility: A Meta-Analysis of 1564 Cases and 2346 Controls. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680871&form=6&db=m Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722300&form=6&db=m Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-?B in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870226&form=6&db=m Sinomenine, a COX-2 inhibitor, induces cell cycle arrest and inhibits growth of human colon carcinoma cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870269&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and interleukin-32 in primary gastric B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26925639&form=6&db=m COX-2 Expression in Renal Cell Carcinoma and Correlations with Tumor Grade, Stage and Patient Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26957558&form=6&db=m MicroRNA MIR21 (miR-21) and PTGS2 expression in colorectal cancer and patient survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959737&form=6&db=m MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26960457&form=6&db=m The role of Ki-67, p16, CD34, Bcl-2, cyclooxygenase-2 in the pathogenesis of proliferative verrucous leukoplakia. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27012907&form=6&db=m Correlation Between Cyclo-oxygenase-2 and Vascular Endothelial Growth Factor Expression in Canine and Feline Squamous Cell Carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27020207&form=6&db=m EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27126210&form=6&db=m Comparison of PTCH1, COX-2, p53, and Ki-67 protein expression in basal cell carcinomas of nodular and superficial subtypes arising on the head and trunk. diagnostic usage,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27148416&form=6&db=m High expression of cyclooxygenase 2 is an indicator of prognosis for patients with esophageal squamous cell carcinoma after Ivor Lewis esophagectomy. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27234549&form=6&db=m HER-2, EGFR, Cox-2 and Ki67 expression in lymph node metastasis of canine mammary carcinomas: Association with clinical-pathological parameters and overall survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27292107&form=6&db=m Augmented Activity of Cyclooxygenase-2 in Tissue and Serum of Patients With Cervical Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27342370&form=6&db=m Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma: Relationship with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27344083&form=6&db=m Aspirin, platelets, and cancer: The point of view of the internist. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27376143&form=6&db=m A Nonselective Cyclooxygenase Inhibitor Enhances the Activity of Vinblastine in a Naturally-Occurring Canine Model of Invasive Urothelial Carcinoma. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27382672&form=6&db=m [Expression of p53, p21, PCNA and COX-2 and its relationship with recurrence in the early-stage laryngeal cancer with negative surgical margin]. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27412115&form=6&db=m COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27456944&form=6&db=m Anti-Cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma (ESCC) through Down-Regulation of COX-2 mRNA and PGE2. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27555783&form=6&db=m miR-203 is involved in the laryngeal carcinoma pathogenesis via targeting VEGFA and Cox-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27577989&form=6&db=m Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27578604&form=6&db=m Retrospective evaluation of COX-2 expression, histological and clinical factors as prognostic indicators in dogs with renal cell carcinomas undergoing nephrectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27628320&form=6&db=m Studies on the Contribution of Cox-2 Expression in the Progression of Oral Squamous Cell Carcinoma and H-Ras Activation. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27854106&form=6&db=m Expression of cyclooxygenase-2 has no impact on survival in adenocarcinoma of the esophagogastric junction but is associated with favourable clinicopathologic features. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27868288&form=6&db=m P21, COX-2, and E-cadherin are potential prognostic factors for esophageal squamous cell carcinoma. diagnostic usage,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27941877&form=6&db=m Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28117391&form=6&db=m Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib. causal interaction,diagnostic usage,unassigned 2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28217972&form=6&db=m Clinical outcome of partial cystectomy for transitional cell carcinoma of the canine bladder. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28230039&form=6&db=m Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272681&form=6&db=m Correlation of COX- 2 Expression in Colorectal Carcinoma with Clinicopathological Features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28301518&form=6&db=m Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28407689&form=6&db=m Radioiodinated indomethacin amide for molecular imaging of cyclooxygenase-2 expressing tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454432&form=6&db=m Prognostic and predictive role of COX-2, XRCC1 and RASSF1 expression in patients with esophageal squamous cell carcinoma receiving radiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489236&form=6&db=m Histologic correlation of VEGF and COX-2 expression with tumor size in squamous cell carcinoma of the larynx and hypopharynx. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521485&form=6&db=m Combination of celecoxib and PD184161 exerts synergistic inhibitory effects on gallbladder cancer cell proliferation. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28553369&form=6&db=m Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599442&form=6&db=m Promoter methylation status of the tumor suppressor genes p16 and cadherin 1 in cervical intraepithelial neoplasia. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28724634&form=6&db=m Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28781660&form=6&db=m Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29190954&form=6&db=m Cyclooxygenase-2 mediated synergistic effect of ursolic acid in combination with paclitaxel against human gastric carcinoma. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254791&form=6&db=m Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29279587&form=6&db=m Cyclooxygenase-2 (COX2) expression in adenocarcinoma surpasses that of squamous cell carcinoma in the uterine cervix. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29373910&form=6&db=m Expression of VEGF and Cox-2 in Patients with Esophageal Squamous Cell Carcinoma diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29492204&form=6&db=m Stromal versus tumoral inflammation differentially contribute to metastasis and poor survival in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512696&form=6&db=m Identification of key genes and long non?coding RNAs in celecoxib?treated lung squamous cell carcinoma cell line by RNA?sequencing. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29609579&form=6&db=m Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29775390&form=6&db=m Polarization and Distribution of Tumor-Associated Macrophages and COX-2 Expression in Basal Cell Carcinoma of the Ocular Adnexae. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29904102&form=6&db=m Targeting PRPK and TOPK for skin cancer prevention and therapy. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003391&form=6&db=m Differential expression of cyclooxygenase-2 and cyclin D1 in salivary gland tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30079321&form=6&db=m Quantitative analysis of COX-2 promoter methylation in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087758&form=6&db=m Effect of Ferula persica plant methanol extract on the level of Cox-2 in induced squamous cell carcinoma (SCC) in rat tongue. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087797&form=6&db=m Evaluation of Cytotoxicity Effects of Chalcone Epoxide Analogues as a Selective COX-II Inhibitor in the Human Liver Carcinoma Cell Line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30104530&form=6&db=m CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30124879&form=6&db=m Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30270026&form=6&db=m Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30314310&form=6&db=m Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30339710&form=6&db=m Expression analysis of cyclooxygenase-2 in patients suffering from esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30392911&form=6&db=m Streptococcus gallolyticus conspires myeloid cells to promote tumorigenesis of inflammatory bowel disease. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30496799&form=6&db=m PIK3CA hotspot mutations and cyclooxygenase-2 expression in ovarian clear cell carcinomas: a close association with stromal features. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559850&form=6&db=m Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580362&form=6&db=m Cyclooxygenase-2 expression in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30591531&form=6&db=m Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30674365&form=6&db=m Significance of immunohistochemical overexpression of cyclooxygenase-2 in overall and disease-free survival of oral squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692057&form=6&db=m Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30798928&form=6&db=m Possible role of PPAR-? and COX-2 receptor modulators in the treatment of Non-Small Cell lung carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30826660&form=6&db=m Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30845292&form=6&db=m Immunoexpression of p53 and COX-2 in basal cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30893857&form=6&db=m Correlation of BRAF Variant V595E, Breed, Histological Grade and Cyclooxygenase-2 Expression in Canine Transitional Cell Carcinomas. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30900666&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31009406&form=6&db=m Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092422&form=6&db=m Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31134158&form=6&db=m Down Regulation of the Expression of ELMO3 by COX2 Inhibitor Suppresses Tumor Growth and Metastasis in Non-Small-Cell Lung Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31179232&form=6&db=m Increased COX-2 Immunostaining in Urothelial Carcinoma of the Urinary Bladder Is Associated with Invasiveness and Poor Prognosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31244433&form=6&db=m COX-2 Docking Structural Analysis with Phytochemical Extracts of Rosemary: A Possible Cytotoxicity on Head and Neck Squamous Cell Carcinoma Cell Line (HEp-2). diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31251418&form=6&db=m Expression of indolamine-2,3-dioxygenase and cyclooxygenase-2 in different disease stages of cutaneous squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31325568&form=6&db=m Gene expression patterns of COX-1, COX-2 and iNOS in H. Pylori infected histopathological conditions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31334675&form=6&db=m The prognostic roles of cyclooxygenase-2 for patients with basal cell carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350224&form=6&db=m Cyclooxygenase and CD147 expression in oral squamous cell carcinoma patient samples and cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423209&form=6&db=m Significance of cyclooxygenase-2, prostaglandin E2 and CD133 levels in sunitinib-resistant renal cell carcinoma. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31523430&form=6&db=m The therapeutic activity of curcumin through its anti-cancer potential on oral squamous cell carcinoma: A study on Sprague Dawley rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31601050&form=6&db=m Mixed-Generation PAMAM G3-G0 Megamer as a Drug Delivery System for Nimesulide: Antitumor Activity of the Conjugate Against Human Squamous Carcinoma and Glioblastoma Cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31792484&form=6&db=m [Expression of CD44v6 and COX-2 in pleomorphic adenomas and carcinomas of parotid gland]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31818070&form=6&db=m [Effect of GPX4 on proliferation and metastasis of renal clear cell carcinoma and its relationship with expression of IGF-1R and COX-2]. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31868102&form=6&db=m Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32173393&form=6&db=m Chemopreventive activity of Tualang honey against oral squamous cell carcinoma-in vivo. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32227417&form=6&db=m Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32235869&form=6&db=m New insights into the functions of Cox-2 in skin and esophageal malignancies. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32257976&form=6&db=m Cyclooxygenase-2 inhibitors delay relapse and reduce Prostate Specific Antigen (PSA) velocity in patients treated with radiotherapy for nonmetastatic prostate cancer: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32272633&form=6&db=m ?-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328138&form=6&db=m Interaction of Cyclooxygenase-2 with Helicobacter pylori Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in Helicobacter pylori-Related Gastric Diseases. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32385388&form=6&db=m Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32410997&form=6&db=m Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435431&form=6&db=m Evaluation of VEGF expression correlates with COX-2 expression in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32505238&form=6&db=m Histopathological and Immunohistochemical Characteristics of Thyroid Carcinoma in the Dog. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655834&form=6&db=m miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32875715&form=6&db=m Combined Targeted Proteomics and Oxylipin Metabolomics for Monitoring of the COX-2 Pathway. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32889812&form=6&db=m Expression of Cyclooxygenase-2 in Human Epithelial Skin Lesions: A Systematic Review of Immunohistochemical Studies. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33023539&form=6&db=m NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33099940&form=6&db=m Postoperative efficacy of low-temperature plasma radiofrequency ablation in elderly patients with laryngeal carcinoma and its influences on tumor markers and COX-2 and VEGF expressions in laryngeal carcinoma tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33137555&form=6&db=m Discovery of novel sulfonamide-containing aminophosphonate derivatives as selective COX-2 inhibitors and anti-tumor candidates. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33245277&form=6&db=m Different Chemical Structures and Physiological/Pathological Roles of Cyclooxygenases. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33287464&form=6&db=m Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441691&form=6&db=m Lipid droplet biogenesis and COX-2 pathway activation are triggered by Barrett's esophagus and adenocarcinoma, but not esophageal squamous cell carcinoma risk factors. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33579312&form=6&db=m Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660890&form=6&db=m Evaluation of HPV and EBV in OSCC and the expression of p53, p16, E-cadherin, COX-2, MYC, and MLH1. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751829&form=6&db=m The role of COX expression in the prognostication of overall survival of canine and feline cancer: A systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33893997&form=6&db=m MiR-124-3p Suppresses Prostatic Carcinoma by Targeting PTGS2 Through the AKT/NF-?B Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33967512&form=6&db=m Immunohistochemical analysis and correlation of cyclooxygenase-2 expression status with clinicopathological parameters in head and neck squamous cell carcinomas: An Indian perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34064434&form=6&db=m Anaplastic Mammary Carcinoma in Cat. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34084214&form=6&db=m Cyclooxygenase-2 expression is associated with chemoresistance through cancer stemness property in hypopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094895&form=6&db=m Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma. unassigned -
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34252545&form=6&db=m Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34320931&form=6&db=m Prediction of lymphovascular space invasion using a combination of tenascin-C, cox-2, and PET/CT radiomics in patients with early-stage cervical squamous cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34321957&form=6&db=m Expression of Human epidermal growth factor receptor 2, Survivin, Enhancer of zeste homolog -2, Cyclooxygenase-2, p53 and p16 molecular markers in Gall bladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395287&form=6&db=m Digital Pathology Scoring of Immunohistochemical Staining Reliably Identifies Prognostic Markers and Anatomical Associations in a Large Cohort of Oral Cancers. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34477058&form=6&db=m Immunohistochemical Expression of Matrix Metalloproteinase-1 and Cyclooxygenase-2 in Cutaneous Squamous Cell and Basal Cell Carcinoma. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731479&form=6&db=m Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582676&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778945&form=6&db=m Up-regulation of cyclooxygenase-2 in squamous carcinogenesis of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873095&form=6&db=m Cyclooxygenase-2 expression is up-regulated in transitional cell carcinoma and its preneoplastic lesions in the human urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11207687&form=6&db=m Bowen's disease (squamous cell carcinoma in situ) in immunosuppressed patients treated with imiquimod 5% cream and a cox inhibitor, sulindac: potential applications for this combination of immunotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11496309&form=6&db=m Cyclooxygenase-2 expression in an adenoid cystic carcinoma of the uterine cervix. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11783060&form=6&db=m [A study on cyclooxygenase-2 protein expression in esophageal carcinoma and premalignant lesions] causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11851614&form=6&db=m Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12408753&form=6&db=m Expression of inflammation related enzymes during experimental rat lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452059&form=6&db=m [A study on cyclooxygenase-2 protein expression and vasculature during experimental rat lung carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576817&form=6&db=m Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871981&form=6&db=m Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352617&form=6&db=m Significance of COX-2 expression in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762637&form=6&db=m Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19046264&form=6&db=m Expression of cyclooxygenase-2 by equine ocular and adnexal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19058955&form=6&db=m Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737986&form=6&db=m Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21262157&form=6&db=m [Cyclooxygenase-2, inducible nitric oxide synthase protein expression and vasculature during experimental rat lung carcinogenesis.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23162641&form=6&db=m Biomarker expression in normal fimbriae: Comparison of high- and low-grade serous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23222816&form=6&db=m Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875558&form=6&db=m Coexpression of COX-2 and iNOS in Angiogenesis of Superficial Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26429877&form=6&db=m Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinoma in Situ http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30339710&form=6&db=m Expression analysis of cyclooxygenase-2 in patients suffering from esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Acinar Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11881728&form=6&db=m Increased expression of cyclooxygenase-2 in human salivary gland tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11496309&form=6&db=m Cyclooxygenase-2 expression in an adenoid cystic carcinoma of the uterine cervix. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25102875&form=6&db=m [Expression and clinical significance of Cox-2 and XIAP in malignant tumors of the salivary gland]. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003391&form=6&db=m Differential expression of cyclooxygenase-2 and cyclin D1 in salivary gland tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinoma, Adenoid Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435431&form=6&db=m Evaluation of VEGF expression correlates with COX-2 expression in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma, Adenosquamous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111807&form=6&db=m Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Adenosquamous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581404&form=6&db=m Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612694&form=6&db=m Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation. unassigned -
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401676&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in skin cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126310&form=6&db=m Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15327557&form=6&db=m Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16185283&form=6&db=m Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16528365&form=6&db=m Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16700663&form=6&db=m Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17307204&form=6&db=m Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18843292&form=6&db=m Tumor-Associated Macrophage-Induced Invasion and Angiogenesis of Human Basal Cell Carcinoma Cells by Cyclooxygenase-2 Induction. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19513627&form=6&db=m Correlation and expression of COX-2 and P53 protein in basal cell carcinoma of eyelid. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051366&form=6&db=m Translating cyclooxygenase signaling in patch heterozygote mice into a randomized clinical trial in basal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115882&form=6&db=m Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21934214&form=6&db=m Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: a pilot study. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159575&form=6&db=m Role of COX-2 activity and CRP levels in patients with non-melanoma skin cancer. -765G>C PTGS2 polymorphism and NMSC risk. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22627629&form=6&db=m The expression of p53 and COX-2 in basal cell carcinoma, squamous cell carcinoma and actinic keratosis cases. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22667343&form=6&db=m Immunohistochemical study of cyclooxygenase-2 in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24518705&form=6&db=m Role of cyclooxygenase-2, ezrin and matrix metalloproteinase-9 as predictive markers for recurrence of basal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301050&form=6&db=m CXCR-4 and COX-2 Expression in Basal Cell Carcinomas and Well-Differentiated Squamous Cell Carcinomas of the Skin; Their Relationship with Tumor Invasiveness and Histological Subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27126210&form=6&db=m Comparison of PTCH1, COX-2, p53, and Ki-67 protein expression in basal cell carcinomas of nodular and superficial subtypes arising on the head and trunk. diagnostic usage,unassigned 1,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28230039&form=6&db=m Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29775390&form=6&db=m Polarization and Distribution of Tumor-Associated Macrophages and COX-2 Expression in Basal Cell Carcinoma of the Ocular Adnexae. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30845292&form=6&db=m Immunoexpression of p53 and COX-2 in basal cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31334675&form=6&db=m The prognostic roles of cyclooxygenase-2 for patients with basal cell carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32889812&form=6&db=m Expression of Cyclooxygenase-2 in Human Epithelial Skin Lesions: A Systematic Review of Immunohistochemical Studies. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Carcinoma, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34477058&form=6&db=m Immunohistochemical Expression of Matrix Metalloproteinase-1 and Cyclooxygenase-2 in Cutaneous Squamous Cell and Basal Cell Carcinoma. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinoma, Bronchogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15246187&form=6&db=m Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Bronchogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16098242&form=6&db=m Chemoprevention strategies with cyclooxygenase-2 inhibitors for lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Bronchogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18304833&form=6&db=m Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Bronchogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19580343&form=6&db=m Immunohistochemical markers of proliferation and vascularisation in preneoplastic bronchial lesions and invasive non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912139&form=6&db=m Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066205&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750248&form=6&db=m Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907138&form=6&db=m Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926055&form=6&db=m Expression of cyclooxygenase-2 in malignant and benign breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681319&form=6&db=m Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717665&form=6&db=m Cyclooxygenase-2 expression: a potential prognostic and predictive marker for high-grade ductal carcinoma in situ of the breast. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14735188&form=6&db=m COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15052544&form=6&db=m Cyclooxygenase-2: a potential target in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499599&form=6&db=m Elevated expression of cyclooxygenase-2 in breast cancer and ductal carcinoma in situ has no correlation with established prognostic markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753376&form=6&db=m p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15842638&form=6&db=m COX-2 expression in DCIS: correlation with VEGF, HER-2/neu, prognostic molecular markers and clinicopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16100520&form=6&db=m Potential use of COX-2-aromatase inhibitor combinations in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16131446&form=6&db=m Localisation of COX-2 protein is different in breast ductal carcinoma and adjacent non-tumour ductal epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16169726&form=6&db=m Expression of cyclooxygenase-2 in breast carcinogenesis and its relation to HER-2/neu and p53 protein expression in invasive ductal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267038&form=6&db=m HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322898&form=6&db=m Correlation of cyclooxygenase-2 and aromatase immunohistochemical expression in invasive ductal carcinoma, ductal carcinoma in situ, and adjacent normal epithelium. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16421596&form=6&db=m Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16428471&form=6&db=m High-resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer. causal interaction,unassigned 2,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507397&form=6&db=m Study of COX-2, Ki67, and p53 expression to predict effectiveness of 5-flurouracil, epirubicin and cyclophosphamide with celecoxib treatment in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17126249&form=6&db=m The status of cyclooxygenase-2 expression in ductal carcinoma in situ lesions and invasive breast cancer correlates to cyclooxygenase-2 expression in normal breast tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17156488&form=6&db=m A novel role for cyclooxygenase-2 in regulating vascular channel formation by human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,3
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17465194&form=6&db=m Cyclooxygenase-2 directly induces MCF-7 breast tumor cells to develop into exponentially growing, highly angiogenic and regionally invasive human ductal carcinoma xenografts. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640394&form=6&db=m Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199541&form=6&db=m Cyclooxygenase-2 expression during immortalization and breast cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218449&form=6&db=m Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19995377&form=6&db=m The Yale University experience of early-stage invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) treated with breast conservation treatment (BCT): analysis of clinical-pathologic features, long-term outcomes, and molecular expression of COX-2, Bcl-2, and p53 as a function of histology. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20028875&form=6&db=m DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20174726&form=6&db=m Expression of cyclooxygenase-2 and its relation to histological grade, inducible nitric oxide synthase, matrix metalloproteinase-2, CD-34, Caspase-3, and CD8 in invasive ductal carcinoma of the breast. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179229&form=6&db=m Cyclooxygenase-2 inhibition does not improve the reduction in ductal carcinoma in situ proliferation with aromatase inhibitor therapy: results of the ERISAC randomized placebo-controlled trial. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20354817&form=6&db=m The value of COX-2 expression in the prognostic parameters of invasive ductal carcinoma of the breast. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476934&form=6&db=m Prognostic Significance of Cyclooxygenase-2 and Response to Chemotherapy in Invasive Ductal Breast Carcinoma Patients by Real Time Surface Plasmon Resonance Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21654686&form=6&db=m A systematic review to establish the frequency of cyclooxygenase-2 expression in normal breast epithelium, ductal carcinoma in situ, microinvasive carcinoma of the breast and invasive breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21678409&form=6&db=m Interplay between membrane lipid peroxidation, transglutaminase activity and cyclooxygenase 2 expression in the tissue adjoining to breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21683430&form=6&db=m Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21822285&form=6&db=m Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21840784&form=6&db=m Cyclooxygenase-2 immunoexpression in breast cancer: Progesterone receptor influence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21920875&form=6&db=m p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249792&form=6&db=m Cyclooxygenase-2 and human epidermal growth factor receptor type 2 (HER-2) expression simultaneously in invasive and in situ breast ductal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22740976&form=6&db=m Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520664&form=6&db=m Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24518566&form=6&db=m Physiological COX-2 Expression in Breast Epithelium Associates with COX-2 Levels in Ductal Carcinoma in Situ and Invasive Breast Cancer in Young Women. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24874483&form=6&db=m COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25077370&form=6&db=m COX-2, p16 and Ki67 expression in DCIS, microinvasive and early invasive breast carcinoma with extensive intraductal component. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25711229&form=6&db=m Co-Expression of p16, Ki67 and COX-2 Is Associated with Basal Phenotype in High-Grade Ductal Carcinoma In Situ of the Breast. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927045&form=6&db=m Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30051683&form=6&db=m COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11917224&form=6&db=m Expression of COX-2, Ki-67, cyclin D1, and P21 in endometrial endometrioid carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Carcinoma, Endometrioid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12469191&form=6&db=m Expression of cyclooxygenase-2 and its relationship to p53 accumulation in ovarian adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8463129&form=6&db=m Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9393671&form=6&db=m Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9618199&form=6&db=m Detection of membrane-bound enzymes in cells using immunoassay and Raman microspectroscopy. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051469&form=6&db=m Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10228831&form=6&db=m Cyclooxygenase-2 expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632332&form=6&db=m Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10930384&form=6&db=m Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156258&form=6&db=m Correspondence re: M. Kondo et al., Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin. Cancer Res., 5: 4005-4012, 1999. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350902&form=6&db=m Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver: possible involvement of COX-2 in the angiogenesis of hepatitis C virus-positive cases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350912&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11756226&form=6&db=m Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11826407&form=6&db=m Absence of nuclear factor kappaB inhibition by NSAIDs in hepatocytes. ongoing research,unassigned 1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11860408&form=6&db=m Expression of cyclooxygenase-2 in chronic hepatitis B and the effects of anti-viral therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11915030&form=6&db=m The MDR phenotype is associated with the expression of COX-2 and iNOS in a human hepatocellular carcinoma cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11981761&form=6&db=m Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12024111&form=6&db=m Rationale and feasibility of chemoprovention of hepatocellular carcinoma by cyclooxygenase-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12046075&form=6&db=m Effect of nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115513&form=6&db=m NS-398, a selective cyclooxygenase 2 inhibitor, inhibited cell growth and induced cell cycle arrest in human hepatocellular carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12201873&form=6&db=m Cyclooxygenase-2 mRNA is up-regulated in cirrhotic or chronic hepatitis liver adjacent to hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297835&form=6&db=m Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12378621&form=6&db=m Significance of cyclooxygenase-2 expression in human primary hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488433&form=6&db=m The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12566320&form=6&db=m Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628514&form=6&db=m Mechanism-based in vitro screening of potential cancer chemopreventive agents. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12632065&form=6&db=m Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398, a selective COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12671717&form=6&db=m Do altering in ornithine decarboxylase activity and gene expression contribute to antiproliferative properties of COX inhibitors? causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12774242&form=6&db=m Cyclo-oxygenase 2 inhibitors: emerging roles in the gut. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12775118&form=6&db=m Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12792783&form=6&db=m Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12901877&form=6&db=m PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12910508&form=6&db=m Hepatocellular carcinoma: is there a potential for chemoprevention using cyclooxygenase-2 inhibitors? causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926063&form=6&db=m Regulatory regions of growth-related genes can activate an exogenous gene of the alpha-fetoprotein promoter to a comparable degree in human hepatocellular carcinoma cells. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939602&form=6&db=m Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963430&form=6&db=m Loss of endogenous TGF-beta effect induces mouse hepatoma malignancy by correlation with cyclooxygenase-2 and VEGF. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14563831&form=6&db=m Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594936&form=6&db=m Chemoprevention of cancer--focusing on clinical trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14675712&form=6&db=m Novel combination of cyclooxygenase-2 and MEK inhibitors in human hepatocellular carcinoma provides a synergistic increase in apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678698&form=6&db=m [Role of cyclooxygenase-2 in the pathogenesis of chronic liver diseases] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767868&form=6&db=m Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14963015&form=6&db=m Cyclooxygenase-2 inhibitors suppress the growth of human hepatocellular carcinoma implants in nude mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010822&form=6&db=m Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15047734&form=6&db=m Distribution of constitutive (COX-1) and inducible (COX-2) cyclooxygenase in postviral human liver cirrhosis: a possible role for COX-2 in the pathogenesis of liver cirrhosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15055524&form=6&db=m The correlation between cyclooxygenase-2 expression and hepatocellular carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15055526&form=6&db=m NS398 inhibits the growth of Hep3B human hepatocellular carcinoma cells via caspase-independent apoptosis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15106735&form=6&db=m Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HepG2 and Hep3B. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15156159&form=6&db=m Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218507&form=6&db=m Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298730&form=6&db=m Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase 2 inhibitor, etodolac, in human hepatocellular carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319438&form=6&db=m Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15519654&form=6&db=m Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15650269&form=6&db=m Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661807&form=6&db=m Prostaglandin E2 promotes migration and adhesion in hepatocellular carcinoma cells. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15800977&form=6&db=m Tumor cyclooxygenase-2 levels correlate with tumor invasiveness in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809909&form=6&db=m Effect of heptitis C virus core protein on cellular gene expression: specific inhibition of cyclooxygenase 2. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15918970&form=6&db=m [The effects of adenovirus-mediated human COX-2 antisense RNA on the growth of hepatocellular carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16014934&form=6&db=m Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16094702&form=6&db=m Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: possible role in tumor promotion and angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273635&form=6&db=m Effects of adenovirus-mediated human cyclooxygenase-2 antisense RNA on the growth of hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299255&form=6&db=m In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16331492&form=6&db=m Cyclooxygenase-2 (COX-2) is directly involved but not decisive in proliferation of human hepatocellular carcinoma cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16331686&form=6&db=m Prostaglandin E(2) receptor EP(1) transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337744&form=6&db=m Cyclooxygenase-2 in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16363629&form=6&db=m Radiosynthesis and in vivo evaluation of 11C-labeled 1,5-diarylpyrazole derivatives for mapping cyclooxygenases. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391822&form=6&db=m The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16419156&form=6&db=m Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507400&form=6&db=m The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16543625&form=6&db=m Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699947&form=6&db=m Proapoptotic activity of NAG-1 is cell type specific and not related to COX-2 expression. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16724692&form=6&db=m Tumor cyclooxygenase-2 gene suppresses local immune responses in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762006&form=6&db=m Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778086&form=6&db=m Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16786154&form=6&db=m COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16793607&form=6&db=m [Diclofenac suppresses hepatoma cell proliferation and promotes cyclooxygenase-2 mRNA expression] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849551&form=6&db=m Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16863510&form=6&db=m Chemoprevention of spontaneous development of hepatocellular carcinomas in fatty liver Shionogi mice by a cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865278&form=6&db=m Cyclooxygenase-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16937518&form=6&db=m Cyclooxygenases in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16995998&form=6&db=m [Effect of saikosaponins-d on cyclooxygenase-2 expression of human hepatocellular carcinoma cell line SMMC-7721.] diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16998298&form=6&db=m [A Case of Complete Regression of Hepatocellular Carcinoma during Administration of COX-2 Inhibitor.] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17015956&form=6&db=m Radiosynthesis and evaluation of 11C-labeled diaryl-substituted imidazole and indole derivatives for mapping cyclooxygenase-2. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17032211&form=6&db=m Regression of hepatocellular carcinoma due to cyclooxygenase (COX)-2 inhibitor. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17074019&form=6&db=m Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17097688&form=6&db=m Potential involvement of the cyclooxygenase-2 pathway in hepatocellular carcinoma-associated angiogenesis. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17146741&form=6&db=m COX-2 expression in hepatocellular carcinoma is an initiation event; while EGF receptor expression with downstream pathway activation is a prognostic predictor of survival. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17160481&form=6&db=m Cyclooxygenase-2 expression in hepatocellular carcinoma, cirrhosis and chronic hepatitis in the United States. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17222364&form=6&db=m [Effects of COX-2 gene silencing by shRNA on biological characteristics of human hepatocellular carcinoma cell line HepG2] diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17275129&form=6&db=m R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17431384&form=6&db=m Combination of cyclooxygenase-2 inhibitor and doxorubicin increases the growth inhibition and apoptosis in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17451196&form=6&db=m Selective COX-2 inhibitor, NS-398, suppresses cellular proliferation in human hepatocellular carcinoma cell lines via cell cycle arrest. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17510421&form=6&db=m P-glycoprotein mediates celecoxib-induced apoptosis in multiple drug-resistant cell lines. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17845691&form=6&db=m Cyclooxygenase-2 expression in chronic hepatitis C and the effect of interferon alpha treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17914586&form=6&db=m Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17959527&form=6&db=m [Inhibitory effects of cyclooxygenase-2 inhibitor celecoxib on the proliferation of hepatocellular carcinoma cells.] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17964630&form=6&db=m NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18092051&form=6&db=m Expression of cyclooxygenase-2 and transforming growth factor-beta1 in HCV-induced chronic liver disease and hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314623&form=6&db=m [Significance of cyclooxygenase-2 as a chemotherapeutic target in hepatocellular carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18373278&form=6&db=m Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18424914&form=6&db=m Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18443952&form=6&db=m Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18506760&form=6&db=m Potent cell growth inhibitory effects in hepatitis B virus X protein positive hepatocellular carcinoma cells by the selective cyclooxygenase-2 inhibitor celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18601905&form=6&db=m COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18613363&form=6&db=m Correlation between expression of cyclooxygenase-2 and the presence of CD4+ infiltrating T-lymphocyte in human primary hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18712978&form=6&db=m Lack of influence of cyclooxygenese-2 expression in hepatocellular carcinomas on patient survival. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18766003&form=6&db=m In-vivo effects and mechanisms of celecoxib-reduced growth of cyclooxygenase-2 (COX-2)-expressing versus COX-2-deleted human HCC xenografts in nude mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815458&form=6&db=m [Down-regulation of survivin in growth inhibition of hepatoma cells induced by a selective cyclooxygenase-2 inhibitor] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19058305&form=6&db=m Inhibitory effect of interferon-alpha-2b on expression of cyclooxygenase-2 and vascular endothelial growth factor in human hepatocellular carcinoma inoculated in nude mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173916&form=6&db=m [Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma] diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250220&form=6&db=m Cyclooxygenase-2 expression in chronic liver diseases and hepatocellular carcinoma: an immunohistochemical study . causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19329856&form=6&db=m Increased expression of cyclooxygenase-2 and increased infiltration of regulatory T cells in tumors of patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19539802&form=6&db=m Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19685055&form=6&db=m Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887546&form=6&db=m Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956533&form=6&db=m Pattern of Apoptosis by NS398, a Selective COX-2 Inhibitor, in Hepatocellular Carcinoma Cell Lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20401641&form=6&db=m Clinical significance of Cox-2, Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC). causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20515870&form=6&db=m Potent antitumor activity in experimental hepatocellular carcinoma by adenovirus-mediated coexpression of TRAIL and shRNA against COX-2. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20652159&form=6&db=m Overexpression of cyclooxygenase-2 in noncancerous liver tissue increases the postoperative recurrence of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20858479&form=6&db=m C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042835&form=6&db=m Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21138631&form=6&db=m [The expression of hepatitis B virus X protein and cyclooxygenase-2 in hepatitis B virus-related hepatocellular carcinoma: correlation with microangiogenesis and metastasis, and what is the possible mechanism]. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205474&form=6&db=m [Effects of celecoxib combined with fluvastatin on tumor growth and cell apoptosis in a xenograft model of hepatocellar carcinoma]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21319995&form=6&db=m Association Between Single Nucleotide Polymorphisms in the Cyclooxygenase-2, Tumor Necrosis Factor-?, and Vascular Endothelial Growth Factor-A Genes, and Susceptibility to Hepatocellular Carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21356386&form=6&db=m Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21457561&form=6&db=m Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21473289&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib attenuates hepatocellular carcinoma growth and c-Met expression in an orthotopic mouse model. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21743491&form=6&db=m Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/?-catenin signaling axis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21744257&form=6&db=m Hepatocyte growth factor upregulation promotes carcinogenesis and epithelial-mesenchymal transition in hepatocellular carcinoma via Akt and COX-2 pathways. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21801152&form=6&db=m Chebulagic Acid Synergizes the Cytotoxicity of Doxorubicin in Human Hepatocellular Carcinoma Through COX-2 Dependant Modulation of MDR-1. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22009181&form=6&db=m Dual action of a selective cyclooxygenase-2 inhibitor on vascular endothelial growth factor expression in human hepatocellular carcinoma cells: novel involvement of discoidin domain receptor 2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22097969&form=6&db=m Cyclooxygenase-2 and Akt mediate multiple growth-factor-induced epithelial-mesenchymal transition in human hepatocellular carcinoma. ongoing research,unassigned 1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159471&form=6&db=m Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: involvement of CCAAT/enhancer binding protein ? and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22225575&form=6&db=m Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis. causal interaction,unassigned 2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22242948&form=6&db=m Association of cyclooxygenase 2 single-nucleotide polymorphisms and hepatocellular carcinoma in taiwan. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340386&form=6&db=m Cyclooxygenase-2 promoter polymorphism -899G/C is associated with hepatitis B-related liver cancer in a Chinese population of Gansu province. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22452660&form=6&db=m Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-?B pathway. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22941037&form=6&db=m Sinomenine hydrochloride enhancement of the inhibitory effects of anti-transferrin receptor antibody-dependent on the COX-2 pathway in human hepatoma cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23091809&form=6&db=m Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23112421&form=6&db=m Nimesulide inhibits the proliferation of HepG2 by up-regulation of Smad4. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226427&form=6&db=m Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23274416&form=6&db=m Therapeutic effect of coenzyme Q10 against experimentally-induced hepatocellular carcinoma in rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23365670&form=6&db=m Green tea phenolic epicatechins inhibit hepatitis C virus replication via cycloxygenase-2 and attenuate virus-induced inflammation. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23494177&form=6&db=m The association between cyclooxygenase-2 1195 G/A polymorphism and hepatocellular carcinoma: evidence from a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23552739&form=6&db=m Evaluation of epigenetic modulation of cyclooxygenase-2 as a prognostic marker for hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23749165&form=6&db=m Proinflammatory conditions promote hepatocellular carcinoma onset and progression via activation of Wnt and EGFR signaling pathways. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23859016&form=6&db=m Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23954207&form=6&db=m Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24372723&form=6&db=m Synergistic effect of simvastatin plus NS398 on inhibition of proliferation and survival in hepatocellular carcinoma cell line. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24398550&form=6&db=m Cyclooxygenase-2 single-nucleotide polymorphisms and hepatocellular carcinoma in Egypt. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24591842&form=6&db=m Cyclooxygenase-2 inhibitor is a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24638056&form=6&db=m Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24675684&form=6&db=m Meloxicam Executes Its Antitumor Effects against Hepatocellular Carcinoma in COX-2- Dependent and -Independent Pathways. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24720952&form=6&db=m COX-2 polymorphisms -765G?C and -1195A?G and hepatocellular carcinoma risk. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24721996&form=6&db=m Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24759835&form=6&db=m Correlation of microRNA-16, microRNA-21 and microRNA-101 expression with cyclooxygenase-2 expression and angiogenic factors in cirrhotic and noncirrhotic human hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25305454&form=6&db=m Hepatitis C virus NS3 protein enhances cancer cell invasion by activating matrix metalloproteinase-9 and cyclooxygenase-2 through ERK/p38/NF-?B signal cascade. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25400773&form=6&db=m Associations between Cox-2 rs20417 and rs5275 polymorphisms and the risk of hepatocellular carcinoma: a meta analysis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25724899&form=6&db=m Interferon-? and cyclooxygenase-2 inhibitor cooperatively mediates TRAIL-induced apoptosis in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25730260&form=6&db=m The Association between Three Cyclooxygenase-2 Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738635&form=6&db=m Exogenous hydrogen sulfide exerts proliferation/anti-apoptosis/angiogenesis/migration effects via amplifying the activation of NF-?B pathway in PLC/PRF/5 hepatoma cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25941430&form=6&db=m Study of the effects of cyclooxygenase-2 inhibitor on the promotion of hepatic tumorigenesis in rats fed a high fat diet. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26060456&form=6&db=m Effect of Ginkgo biloba extract on the expressions of Cox-2 and GST-Pi in rats with hepatocellular carcinoma risk. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26136881&form=6&db=m Cidan inhibits liver cancer cell growth by reducing COX-2 and VEGF expression and cell cycle arrest. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26193270&form=6&db=m A New Ligustrazine Derivative-Selective Cytotoxicity by Suppression of NF-?B/p65 and COX-2 Expression on Human Hepatoma Cells. Part 3. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26334888&form=6&db=m Common Variants of the Prostaglandin-Endoperoxide Synthase 2 Gene and Hepatocellular Carcinoma Susceptibility. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26438136&form=6&db=m Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26550156&form=6&db=m Cyclooxygenase-2 -1195G>A (rs689466) polymorphism and cancer susceptibility: an updated meta-analysis involving 50,672 subjects. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26554780&form=6&db=m COX-2 Promotes Migration and Invasion by the Side Population of Cancer Stem Cell-Like Hepatocellular Carcinoma Cells. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26619541&form=6&db=m [The Expressions of Somatostatin and Cycloxygenase-2 in Chronic Hepatitis, Hepatic Cirrhosis, Precancerous Lesion and Hepatocellular Carcinoma]. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26801163&form=6&db=m Effect of perioperative parecoxib sodium on postoperative pain control for transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma: a prospective randomized trial. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26846471&form=6&db=m A randomised controlled trial of meloxicam, a Cox-2 inhibitor, to prevent hepatocellular carcinoma recurrence after initial curative treatment. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881519&form=6&db=m Cyclooxygenase-2 expression is associated with elevated aspartate aminotransferase level in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26984380&form=6&db=m Regulation of COX-2 expression and epithelial-to-mesenchymal transition by hypoxia-inducible factor-1? is associated with poor prognosis in hepatocellular carcinoma patients post TACE surgery. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27173352&form=6&db=m Functional polymorphisms of the cyclooxygenase-2 gene and prognosis of hepatocellular carcinoma - a cohort study in Chinese people. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27261618&form=6&db=m Targeted nano-delivery of novel omega-3 conjugate against hepatocellular carcinoma: Regulating COX-2/bcl-2 expression in an animal model. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27695503&form=6&db=m Prognostic significance of cyclooxygenase-2 expression in patients with hepatocellular carcinoma: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27818595&form=6&db=m Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27982164&form=6&db=m Immunohistochemical angiogenic biomarkers in hepatocellular carcinoma and cirrhosis: correlation with pathological features. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28246472&form=6&db=m Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28317866&form=6&db=m Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28342979&form=6&db=m Guggulsterone sensitized drug-resistant human hepatocarcinoma cells to doxorubicin through a Cox-2/P-gp dependent pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28346420&form=6&db=m Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634076&form=6&db=m lncRNA HULC promotes the growth of hepatocellular carcinoma cells via stabilizing COX-2 protein. unassigned -
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29098441&form=6&db=m Communicative reprogramming non-curative hepatocellular carcinoma with low-dose metronomic chemotherapy, COX-2 inhibitor and PPAR-gamma agonist: a phase II trial. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29131381&form=6&db=m Long non-coding RNA cox-2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29295728&form=6&db=m MiR-136 inhibits malignant progression of hepatocellular carcinoma cells by targeting cyclooxygenase 2. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29505957&form=6&db=m COX-2 Forms Regulatory Loop with YAP to Promote Proliferation and Tumorigenesis of Hepatocellular Carcinoma Cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29578159&form=6&db=m Cyclooxygenase-2 gene polymorphisms and susceptibility to hepatocellular carcinoma: A meta-analysis based on 10 case-control studies. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29725404&form=6&db=m Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081711&form=6&db=m Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087797&form=6&db=m Evaluation of Cytotoxicity Effects of Chalcone Epoxide Analogues as a Selective COX-II Inhibitor in the Human Liver Carcinoma Cell Line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30182439&form=6&db=m Celecoxib alleviates AKT/c-Met-triggered rapid hepatocarcinogenesis by suppressing a novel COX-2/AKT/FASN cascade. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30287340&form=6&db=m Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma. unassigned -
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30346255&form=6&db=m Decorating protein nanospheres with lactoferrin enhances oral COX-2 inhibitor/herbal therapy of hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30365092&form=6&db=m COX-2 induces apoptosis-resistance in hepatocellular carcinoma cells via the HIF-1?/PKM2 pathway. unassigned -
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30612458&form=6&db=m In Vitro and In Vivo Protective Effects of Flavonoid-Enriched Lotus Seedpod Extract on Lipopolysaccharide-Induced Hepatic Inflammation. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30653402&form=6&db=m A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery. unassigned -
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30810331&form=6&db=m Altered expression of COX-2 and TNF-? in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31114336&form=6&db=m Suppressing growth and invasion of human hepatocellular carcinoma cells by celecoxib through inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31213849&form=6&db=m Knockdown of cyclooxygenase-2 leads to growth inhibition and cell cycle arrest in hepatocellular carcinoma cells. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31331008&form=6&db=m Melatonin and (-)-Epigallocatechin-3-Gallate: Partners in Fighting Cancer. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31679460&form=6&db=m RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31888113&form=6&db=m Endoplasmic Reticulum Stress-Induced Resistance to Doxorubicin Is Reversed by Mulberry Leaf Polyphenol Extract in Hepatocellular Carcinoma through Inhibition of COX-2. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32072904&form=6&db=m Anti-tumorigenic efficacy of Tangeretin in Liver Cancer - An in-silico approach. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,4
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32273947&form=6&db=m Meloxicam, a Selective COX-2 Inhibitor, Mediates Hypoxia-Inducible Factor- (HIF-) 1? Signaling in Hepatocellular Carcinoma. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328199&form=6&db=m Synergistic Effects of Curcumin and 5-Fluorouracil on the Hepatocellular Carcinoma In vivo and vitro through regulating the expression of COX-2 and NF-?B. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32755957&form=6&db=m Chitosan nanoparticles loaded with aspirin and 5-fluororacil enable synergistic antitumour activity through the modulation of NF-?B/COX-2 signalling pathway. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801214&form=6&db=m Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression. unassigned -
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33033527&form=6&db=m Novel combination of celecoxib and metformin improves the antitumor effect by inhibiting the growth of Hepatocellular Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33825221&form=6&db=m Microalgal extract from thermotolerant Coelastrella sp. F50 retards the liver tumor progression by targeting hepatic cancer stem cells. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34093801&form=6&db=m MicroRNA-30a-3p acts as a tumor suppressor in MHCC-97H hepatocellular carcinoma cells by targeting COX-2. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34150019&form=6&db=m Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization. unassigned -
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135226&form=6&db=m COX-2 is expressed in human pulmonary, colonic, and mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912139&form=6&db=m Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750248&form=6&db=m Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926055&form=6&db=m Expression of cyclooxygenase-2 in malignant and benign breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681319&form=6&db=m Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717665&form=6&db=m Cyclooxygenase-2 expression: a potential prognostic and predictive marker for high-grade ductal carcinoma in situ of the breast. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14735188&form=6&db=m COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499599&form=6&db=m Elevated expression of cyclooxygenase-2 in breast cancer and ductal carcinoma in situ has no correlation with established prognostic markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753376&form=6&db=m p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15842638&form=6&db=m COX-2 expression in DCIS: correlation with VEGF, HER-2/neu, prognostic molecular markers and clinicopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16100520&form=6&db=m Potential use of COX-2-aromatase inhibitor combinations in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267038&form=6&db=m HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322898&form=6&db=m Correlation of cyclooxygenase-2 and aromatase immunohistochemical expression in invasive ductal carcinoma, ductal carcinoma in situ, and adjacent normal epithelium. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391819&form=6&db=m COX-2 induction by heparanase in the progression of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16421596&form=6&db=m Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17126249&form=6&db=m The status of cyclooxygenase-2 expression in ductal carcinoma in situ lesions and invasive breast cancer correlates to cyclooxygenase-2 expression in normal breast tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640394&form=6&db=m Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199541&form=6&db=m Cyclooxygenase-2 expression during immortalization and breast cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18237383&form=6&db=m COX-2 and PPARgamma expression are potential markers of recurrence risk in mammary duct carcinoma in-situ. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218449&form=6&db=m Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20028875&form=6&db=m DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20103725&form=6&db=m Cyclooxygenase-2 inhibition for the prophylaxis and treatment of preinvasive breast cancer in a her-2/neu mouse model. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179229&form=6&db=m Cyclooxygenase-2 inhibition does not improve the reduction in ductal carcinoma in situ proliferation with aromatase inhibitor therapy: results of the ERISAC randomized placebo-controlled trial. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227160&form=6&db=m Cyclo-oxygenase type 2 is dysregulated in breast ductal carcinoma in situ and correlates with poor outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20427430&form=6&db=m Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21371829&form=6&db=m Immunohistochemical COX-2 overexpression correlates with HER-2/neu overexpression in invasive breast carcinomas: A pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21654686&form=6&db=m A systematic review to establish the frequency of cyclooxygenase-2 expression in normal breast epithelium, ductal carcinoma in situ, microinvasive carcinoma of the breast and invasive breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21678409&form=6&db=m Interplay between membrane lipid peroxidation, transglutaminase activity and cyclooxygenase 2 expression in the tissue adjoining to breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21683430&form=6&db=m Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21822285&form=6&db=m Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21920875&form=6&db=m p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249792&form=6&db=m Cyclooxygenase-2 and human epidermal growth factor receptor type 2 (HER-2) expression simultaneously in invasive and in situ breast ductal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22740976&form=6&db=m Interaction between cyclooxygenase-2 and insulin-like growth factor in breast cancer: A new field for prevention and treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23216814&form=6&db=m Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24518566&form=6&db=m Physiological COX-2 Expression in Breast Epithelium Associates with COX-2 Levels in Ductal Carcinoma in Situ and Invasive Breast Cancer in Young Women. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24874483&form=6&db=m COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25077370&form=6&db=m COX-2, p16 and Ki67 expression in DCIS, microinvasive and early invasive breast carcinoma with extensive intraductal component. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25711229&form=6&db=m Co-Expression of p16, Ki67 and COX-2 Is Associated with Basal Phenotype in High-Grade Ductal Carcinoma In Situ of the Breast. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26317313&form=6&db=m Her2 and Ki67 Biomarkers Predict Recurrence of Ductal Carcinoma in Situ. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27146587&form=6&db=m Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29685879&form=6&db=m Clinicopathological Risk Factors for an Invasive Breast Cancer Recurrence after Ductal Carcinoma In Situ-A Nested Case-Control Study. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30051683&form=6&db=m COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147051&form=6&db=m Expression of COX-2, p16, and Ki67 in the range from normal breast tissue to breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Carcinoma, Intraductal, Noninfiltrating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33753731&form=6&db=m Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Large Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515422&form=6&db=m Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3089171&form=6&db=m [Anti-cancer treatment with prostaglandin synthetase inhibitor in animal models] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3926304&form=6&db=m Prostaglandin and thromboxane synthesis by Lewis lung carcinoma during growth. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137463&form=6&db=m Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapies. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8275495&form=6&db=m Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10605031&form=6&db=m Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11239499&form=6&db=m Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19000324&form=6&db=m Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19799610&form=6&db=m Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110411&form=6&db=m COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731664&form=6&db=m Nucleotide-binding domain of phosphoglycerate kinase 1 reduces tumor growth by suppressing COX-2 expression. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21559762&form=6&db=m Inhibitory effect of celecoxib in lung carcinoma by regulation of cyclooxygenase-2/cytosolic phospholipase A(2) and peroxisome proliferator-activated receptor gamma. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613332&form=6&db=m [Effects of tea polyphenols on the expression of NF-?B, COX-2 and survivin in Lewis lung carcinoma xenografts in C57BL/6 mice]. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226772&form=6&db=m Vascular endothelial growth factor promotes the expression of cyclooxygenase 2 and matrix metalloproteinases in Lewis lung carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25271626&form=6&db=m Prostanoid induces premetastatic niche in regional lymph nodes. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30591531&form=6&db=m Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Lewis Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31134158&form=6&db=m Down Regulation of the Expression of ELMO3 by COX2 Inhibitor Suppresses Tumor Growth and Metastasis in Non-Small-Cell Lung Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Carcinoma, Lobular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907138&form=6&db=m Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Lobular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19995377&form=6&db=m The Yale University experience of early-stage invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) treated with breast conservation treatment (BCT): analysis of clinical-pathologic features, long-term outcomes, and molecular expression of COX-2, Bcl-2, and p53 as a function of histology. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Carcinoma, Medullary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12596060&form=6&db=m Mucinous colon carcinomas with microsatellite instability have a lower microvessel density and lower vascular endothelial growth factor expression. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0
1.14.99.1 Carcinoma, Medullary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665651&form=6&db=m An immunohistochemical survey of nine cases of medullary carcinoma of thyroid including reactivity for Cox-1 and Cox-2 enzymes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Carcinoma, Medullary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717230&form=6&db=m Immunohistochemical expression of COX-2 in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Medullary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17179688&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in thyroid neoplasms and their clinicopathological correlation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinoma, Merkel Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15660656&form=6&db=m Cyclooxygenase-2 expression in primary Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma, Merkel Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18594470&form=6&db=m Cyclooxygenase-2 expression in primary and metastatic Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11881728&form=6&db=m Increased expression of cyclooxygenase-2 in human salivary gland tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880952&form=6&db=m Cyclooxygenase-2 regulates the degree of apoptosis by modulating bcl-2 protein in pleomorphic adenoma and mucoepidermoid carcinoma of the parotid gland. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17448140&form=6&db=m Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19729335&form=6&db=m Malignant salivary gland tumors and cyclo-oxygenase-2: A histopathological and immunohistochemical analysis with implications on histogenesis. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19751908&form=6&db=m Predictive value of cyclooxygenase 2 and Bcl-2 for cervical lymph node metastasis in mucoepidermoid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25102875&form=6&db=m [Expression and clinical significance of Cox-2 and XIAP in malignant tumors of the salivary gland]. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003391&form=6&db=m Differential expression of cyclooxygenase-2 and cyclin D1 in salivary gland tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinoma, Mucoepidermoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435431&form=6&db=m Evaluation of VEGF expression correlates with COX-2 expression in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma, Neuroendocrine http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15660656&form=6&db=m Cyclooxygenase-2 expression in primary Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma, Neuroendocrine http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16014119&form=6&db=m Expression of HER-2/neu, epidermal growth factor receptor, vascular endothelial growth factor, cyclooxygenase-2, estrogen receptor, and progesterone receptor in small cell and large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathologic and prognostic study. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515422&form=6&db=m Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10626810&form=6&db=m Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10815926&form=6&db=m Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062695&form=6&db=m Meloxicam inhibits the growth of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093779&form=6&db=m Induction of p27(KIP1) as a mechanism underlying NS398-induced growth inhibition in human lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156228&form=6&db=m Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309334&form=6&db=m Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11320076&form=6&db=m Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11850726&form=6&db=m Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with DeltaE1, DeltaE3 recombinant adenovirus vectors. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882767&form=6&db=m Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11895880&form=6&db=m Hierarchical clustering of lung cancer cell lines using DNA methylation markers. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297183&form=6&db=m Adenoid cystic carcinoma of the trachea and bronchus--a clinicopathologic study with DNA flow cytometric analysis and oncogene expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369871&form=6&db=m Selective cyclooxygenase-2 inhibitors and non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393872&form=6&db=m Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499088&form=6&db=m Epidermal growth factor receptors and cyclooxygenase-2 in the pathogenesis of non-small cell lung cancer: potential targets for chemoprevention and systemic therapy. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591723&form=6&db=m Abnormal interleukin 10Ralpha expression contributes to the maintenance of elevated cyclooxygenase-2 in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631609&form=6&db=m Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12633561&form=6&db=m Cyclooxygenase-2 in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12660005&form=6&db=m Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738712&form=6&db=m Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895344&form=6&db=m [Overexpression of COX-2 and its clinical significance in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14568683&form=6&db=m Correlation between cyclooxygenase-2 and tumor angiogenesis in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14604894&form=6&db=m Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14610920&form=6&db=m Emerging drugs for non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14676104&form=6&db=m Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokers. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14739609&form=6&db=m Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14971881&form=6&db=m Overexpression of cyclooxygenase-2 in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981580&form=6&db=m Improvement strategies for molecular targeting: Cyclooxygenase-2 inhibitors as radiosensitizers for non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996749&form=6&db=m Cyclooxygenase-2-dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15068324&form=6&db=m HER-2, EGFR, COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179623&form=6&db=m COX-2 inhibition and lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217972&form=6&db=m Cyclooxygenase as a target in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256475&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265936&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374938&form=6&db=m Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15704107&form=6&db=m Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15777970&form=6&db=m Cyclooxygenase-2 protein levels are independent of epidermal growth factor receptor expression or activation in operable non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15825163&form=6&db=m COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15829328&form=6&db=m Docetaxel and cyclooxygenase-2 inhibition with celecoxib for advanced non-small cell lung cancer progressing after platinum-based chemotherapy: a multicenter phase II trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867233&form=6&db=m A phase I clinical trial of thoracic radiotherapy and concurrent celecoxib for patients with unfavorable performance status inoperable/unresectable non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870920&form=6&db=m Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930356&form=6&db=m Chemotherapy induces the expression of cyclooxygenase-2 in non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15942563&form=6&db=m Evaluation of cyclooxygenase-2 inhibition in an orthotopic murine model of lung cancer for dose-dependent effect. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15950941&form=6&db=m IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15958566&form=6&db=m Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16002678&form=6&db=m Cyclooxygenase 2 inhibition promotes IFN-gamma-dependent enhancement of antitumor responses. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16005433&form=6&db=m Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16010430&form=6&db=m Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053662&form=6&db=m Targeting COX-2/PG-E2 with a COX-2 inhibitor in combination with chemotherapy for non-small cell lung cancer: are we ready for phase III? therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053664&form=6&db=m The combination of the selective cyclooxygenase-2 inhibitor celecoxib with weekly paclitaxel is a safe and active second-line therapy for non-small cell lung cancer: a phase II study with biological correlates. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16102610&form=6&db=m Cross-talk between cyclooxygenase-2 and epidermal growth factor receptor in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16119982&form=6&db=m Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166442&form=6&db=m Targeting cyclooxygenase-2 in recurrent non-small cell lung cancer: a phase II trial of celecoxib and docetaxel. unassigned -
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256796&form=6&db=m Dimethyl celecoxib as a novel non-cyclooxygenase 2 therapy in the treatment of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256823&form=6&db=m Association between cyclooxygenase and epidermal growth factor receptor pathways in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16278387&form=6&db=m Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376453&form=6&db=m COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16397226&form=6&db=m Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16452236&form=6&db=m The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16483484&form=6&db=m [Expression of vascular endothelial growth factor C and cyclooxygenase-2 in non-small-cell lung carcinoma and their clinical significance.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16574063&form=6&db=m IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685393&form=6&db=m Interferon-alpha resistance can be reversed by inhibition of IFN-alpha-induced COX-2 expression potentially via STAT1 activation in A549 cells. ongoing research,unassigned 2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707460&form=6&db=m Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712449&form=6&db=m The potential and rationale for COX-2 inhibitors in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16735371&form=6&db=m Association between cyclooxygenase-2 and matrix metalloproteinase-2 expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740761&form=6&db=m A phase I trial to determine the optimal biological dose of celecoxib when combined with erlotinib in advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820889&form=6&db=m PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872953&form=6&db=m Perioperative cyclooxygenase 2 inhibition to reduce tumor cell adhesion and metastatic potential of circulating tumor cells in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16969492&form=6&db=m Cyclooxygenase-2 inhibitor, nimesulide, improves radiation treatment against non-small cell lung cancer both in vitro and in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996907&form=6&db=m Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237224&form=6&db=m Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237818&form=6&db=m Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17394509&form=6&db=m Correlation of cyclooxygenase-2 expression with hypoxia in non-small cell lung cancer. unassigned -
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409801&form=6&db=m Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non-small cell lung cancer (NSCLC). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17600311&form=6&db=m EGFR Signaling Is Required for TGF-beta1 Mediated COX-2 Induction in Human Bronchial Epithelial Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17602268&form=6&db=m Characterization of the effects of cyclooxygenase-2 inhibition in the regulation of apoptosis in human small and non-small cell lung cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17697767&form=6&db=m Ciglitazone mediates COX-2 dependent suppression of PGE2 in human non-small cell lung cancer cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18003891&form=6&db=m Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18172786&form=6&db=m Selective COX-2 inhibitor celecoxib combined with EGFR-TKI ZD1839 on non-small cell lung cancer cell lines: in vitro toxicity and mechanism study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18348652&form=6&db=m NS-398 enhances the efficacy of gemcitabine against lung adenocarcinoma through up-regulation of p21WAF1 and p27KIP1 protein. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381949&form=6&db=m The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,2
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18453539&form=6&db=m COX-2/EGFR expression and survival among women with adenocarcinoma of the lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18671849&form=6&db=m Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18978565&form=6&db=m Phase II study of docetaxel and celecoxib, a cyclooxygenase-2 inhibitor, in elderly or poor performance status (PS2) patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19031941&form=6&db=m Positive correlation between cyclooxygenase 2 and the expression of ABC transporters in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19157634&form=6&db=m The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19217709&form=6&db=m Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19235531&form=6&db=m Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19238334&form=6&db=m The expression of COX-2, hTERT, MDM2, LATS2 and S100A2 in different types of non-small cell lung cancer (NSCLC). ongoing research,unassigned 1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280060&form=6&db=m Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19417670&form=6&db=m Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19703066&form=6&db=m Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19818596&form=6&db=m Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20016751&form=6&db=m Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20047843&form=6&db=m Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20132963&form=6&db=m Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145019&form=6&db=m Proanthocyanidins inhibit in vitro and in vivo growth of human non-small cell lung cancer cells by inhibiting the prostaglandin E(2) and prostaglandin E(2) receptors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20234320&form=6&db=m Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332326&form=6&db=m Cyclooxygenase-2 genetic variants are associated with survival in unresectable locally advanced non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592629&form=6&db=m Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716424&form=6&db=m [The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731947&form=6&db=m [A phase II clinical trial of celecoxib combined with platinum-based chemotherapy in the treatment of patients with advanced NSCLC as first-line treatment.] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20922800&form=6&db=m Biomarker-based phase I dose-escalation, pharmacokinetic, and pharmacodynamic study of oral apricoxib in combination with erlotinib in advanced nonsmall cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21081043&form=6&db=m [Expression and significance of COX-2 and its transcription factors NFAT3 and c-Jun in non-small cell lung cancer]. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21114937&form=6&db=m [Prognostic value of survivin and cyclooxygenase-2 expression in non-small cell lung cancer: a tissue microarray analysis.] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118643&form=6&db=m [Suppression of COX-2 protein to cell apoptosis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205525&form=6&db=m [Effects of cyclooxygenase-2 antisense vector on proliferation and sensitivity to cisplatin of H1299 cells.] causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215004&form=6&db=m [Expression of COX-2 and its prognostic significance in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219643&form=6&db=m Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21234531&form=6&db=m Celecoxib enhances radiation response of secondary bone tumors of a human non-small cell lung cancer via antiangiogenesis in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21251407&form=6&db=m [Study of COX-2 expression and angiogenesis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21385353&form=6&db=m EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443775&form=6&db=m Correction: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21472198&form=6&db=m Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21507199&form=6&db=m IL-10 production in non-small cell lung carcinoma patients is regulated by ERK, P38 and COX-2. unassigned -
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21565487&form=6&db=m Effect of celecoxib on survival in patients with advanced non-small cell lung cancer: a double blind randomised clinical phase III trial (CYCLUS study) by the Swedish Lung Cancer Study Group. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21565488&form=6&db=m IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22482414&form=6&db=m [Expression and clinical significance of CD3, CD4 and COX-2 in non-small cell lung cancer]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22649768&form=6&db=m Phase I study of celecoxib with concurrent irinotecan, Cisplatin, and radiation therapy for patients with unresectable locally advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22678114&form=6&db=m Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22803374&form=6&db=m [Effect of NF-kappaB on inhibition of non-small cell lung cancer cell cyclooxygenase-2 by brucine]. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23172668&form=6&db=m Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23372950&form=6&db=m Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384501&form=6&db=m Cox-2 in non-small cell lung cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,3
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23620771&form=6&db=m The association between COX-2 polymorphisms and hematologic toxicity in patients with advanced non-small-cell lung cancer treated with platinum-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24344016&form=6&db=m Lentivirus-mediated shRNA interference targeting cyclooxygenase-2 inhibits growth of human non-small cell lung cancer. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24549815&form=6&db=m Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25113252&form=6&db=m COX-2 overexpression and -8473 T/C polymorphism in 3' UTR in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131817&form=6&db=m Prognostic value of cyclooxygenase-2 gene polymorphisms in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25137041&form=6&db=m Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202373&form=6&db=m Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25252849&form=6&db=m Hu-antigen receptor (HuR) and cyclooxygenase-2 (COX-2) expression in human non-small-cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25338928&form=6&db=m Cyclooxygenase-2 genetic variants influence intratumoral infiltration of Foxp3-positive regulatory T cells in non-small cell lung cancer. diagnostic usage,unassigned 4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25411520&form=6&db=m Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25449785&form=6&db=m Prognostic impact of COX-2 in non-small cell lung cancer: a comprehensive compartment-specific evaluation of tumor and stromal cell expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25817787&form=6&db=m USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25888998&form=6&db=m Cyclooxygenase-2 expression is a prognostic biomarker for non-small cell lung cancer patients treated with adjuvant platinum-based chemotherapy. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25975224&form=6&db=m The VEGFR2, COX-2 and MMP-2 polymorphisms are associated with clinical outcome of patients with inoperable non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26033783&form=6&db=m Cyclooxygenase 2 inhibition in patients with non-small cell lung cancer: Is this still a valid target for therapy? diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26033830&form=6&db=m Randomized phase 2 trial of erlotinib in combination with high-dose celecoxib or placebo in patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26045835&form=6&db=m Association between COX-2 polymorphisms and non-small cell lung cancer susceptibility. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26452035&form=6&db=m Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464643&form=6&db=m Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 Level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629442&form=6&db=m Revisiting the role of COX-2 inhibitor for non-small cell lung cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26777972&form=6&db=m Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27007231&form=6&db=m Clinical Profile of Cyclooxygenase-2 Inhibitors in Treating Non-Small Cell Lung Cancer: A Meta-Analysis of Nine Randomized Clinical Trials. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27696404&form=6&db=m Retraction. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28413655&form=6&db=m Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789387&form=6&db=m Urinary levels of prostaglandin E2 are positively correlated with intratumoral infiltration of Foxp3(+) regulatory T cells in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28837884&form=6&db=m Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/?-catenin signalling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29140138&form=6&db=m COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29236213&form=6&db=m Structural Probing, Screening and Structure-Based Drug Repositioning Insights into the Identification of Potential Cox-2 Inhibitors from Selective Coxibs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29982425&form=6&db=m Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30798928&form=6&db=m Possible role of PPAR-? and COX-2 receptor modulators in the treatment of Non-Small Cell lung carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31115011&form=6&db=m COX-2 potentiates cisplatin resistance of non-small cell lung cancer cells by promoting EMT in an AKT signaling pathway-dependent manner. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31440159&form=6&db=m The Role of Prostaglandin-Endoperoxide Synthase-2 in Chemoresistance of Non-Small Cell Lung Cancer. unassigned -
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31851351&form=6&db=m Effect of Concurrent Chemoradiation With Celecoxib vs Concurrent Chemoradiation Alone on Survival Among Patients With Non-Small Cell Lung Cancer With and Without Cyclooxygenase 2 Genetic Variants: A Phase 2 Randomized Clinical Trial. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31868102&form=6&db=m Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32284763&form=6&db=m Cyclooxygenase-2 mediates gefitinib resistance in non-small cell lung cancer through the EGFR/PI3K/AKT axis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33553396&form=6&db=m Clinical benefit of COX-2 inhibitors in the adjuvant chemotherapy of advanced non-small cell lung cancer: A systematic review and meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33559253&form=6&db=m Effect of cyclooxygenase inhibitor use on immunotherapy efficacy in non-small cell lung cancer. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34252545&form=6&db=m Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009392&form=6&db=m Effects of prostaglandin E(2) on proliferation and apoptosis of epithelial ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648598&form=6&db=m Inhibition of paclitaxel-induced apoptosis by the specific COX-2 inhibitor, NS398, in epithelial ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766256&form=6&db=m Cyclooxygenase-1 and 2 in normal and malignant human ovarian epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14984962&form=6&db=m Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15266333&form=6&db=m Clinical implication of expression of cyclooxygenase-2 and peroxisome proliferator activated-receptor gamma in epithelial ovarian tumours. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15607554&form=6&db=m Lower expression of cyclooxygenase-2: is it associated with the development of borderline ovarian tumors? causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15711411&form=6&db=m COX-2: a protein with an active role in gynecological cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867369&form=6&db=m Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510568&form=6&db=m Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. causal interaction,unassigned 3,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17107625&form=6&db=m Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17309668&form=6&db=m The prognostic importance of cyclooxygenase 2 and HER2 expression in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17667594&form=6&db=m The effects of combining docetaxel and cyclooxygenase-2 inhibitors on proliferation and apoptosis in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919376&form=6&db=m [The expression of MRP, GST-pi, Topo IIalpha and COX-2 in epithelial ovarian cancer and its relationship to drug resistance and prognosis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19271346&form=6&db=m Expression of cyclooxygenase-1 in epithelial ovarian cancer: a clinicopathological study. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19559517&form=6&db=m Cox-2 expression in ovarian malignancies: a review of the clinical aspects. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19621391&form=6&db=m Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19899409&form=6&db=m Cox-2 immunohistochemical expression in epithelial ovarian carcinoma and platin sensitivity. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21107726&form=6&db=m Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22652675&form=6&db=m CD24, COX-2, and p53 in epithelial ovarian cancer and its clinical significance. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689176&form=6&db=m A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,4
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23422504&form=6&db=m Prognostic role of cyclooxygenase-2 in epithelial ovarian cancer: A meta-analysis of observational studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24832612&form=6&db=m PET radiotracer [¹?F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27111555&form=6&db=m COX-1 Inhibitors: Beyond Structure Toward Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599493&form=6&db=m Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29147175&form=6&db=m Expression of Cyclooxygenase-1 and 2 in Epithelial Ovarian Cancer: A Clinicopathologic Study. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29324448&form=6&db=m The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29727350&form=6&db=m Cyclooxygenase Inhibitors in Epithelial Ovarian Cancer Treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29932878&form=6&db=m COX-2 inhibition by celecoxib in epithelial ovarian cancer attenuates E-cadherin suppression through reduced Snail nuclear translocation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11939728&form=6&db=m Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713627&form=6&db=m Cyclooxygenase-2 expression in thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717230&form=6&db=m Immunohistochemical expression of COX-2 in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475935&form=6&db=m Role of COX-2, thromboxane A2 synthase, and prostaglandin I2 synthase in papillary thyroid carcinoma growth. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947945&form=6&db=m Cyclooxygenase-2 in normal, hyperplastic and neoplastic follicular cells of the human thyroid gland. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16362262&form=6&db=m Cyclooxygenase 1 and 2 expressions in the human thyroid gland. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17179688&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in thyroid neoplasms and their clinicopathological correlation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18296437&form=6&db=m Chemopreventive effects of a selective cyclooxygenase-2 inhibitor (etodolac) on chemically induced intraductal papillary carcinoma of the pancreas in hamsters. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19391129&form=6&db=m COX-2 is induced by HGF stimulation in Met-positive thyroid papillary carcinoma cells and is involved in tumour invasiveness. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23617728&form=6&db=m Papillary Carcinoma of the Thyroid: High Expression of COX-2 and Low Expression of KAI-1/CD82 Are Associated with Increased Tumor Invasiveness. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339385&form=6&db=m Combined use of COX-1 and VEGF immunohistochemistry refines the histopathologic prognosis of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498465&form=6&db=m Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521457&form=6&db=m Expression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28548071&form=6&db=m The Pathogenetic Role of the HGF/c-Met System in Papillary Carcinoma of the Thyroid. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2937933&form=6&db=m Altered 1-14C arachidonic acid metabolism in arterial wall from patients with renal cell carcinoma. diagnostic usage,unassigned 2,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11199159&form=6&db=m Expression of cyclooxygenase-2 in canine renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12708469&form=6&db=m Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738729&form=6&db=m Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14712483&form=6&db=m Significance of COX-2 expression in human renal cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719128&form=6&db=m Study of cyclooxygenase-2 in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15049901&form=6&db=m Cyclooxygenase-2 expression and relationship to tumour progression in human renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138613&form=6&db=m The effects of cyclooxygenase-2 inhibitors on urological cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15538221&form=6&db=m Impact of cyclooxygenase-2 gene expression on tumor invasiveness in a human renal cell carcinoma cell line. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569051&form=6&db=m Comparative analysis of COX-2, vascular endothelial growth factor and microvessel density in human renal cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596182&form=6&db=m Significance of COX-2 expression in human renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15744816&form=6&db=m Cyclooxygenase-2 and p53 expression as prognostic indicators in conventional renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080553&form=6&db=m Cyclooxygenase-2 expression in brain metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16157291&form=6&db=m Localization of cyclooxygenases-1 and -2, and prostaglandin F synthase in human kidney and renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16369983&form=6&db=m Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16426736&form=6&db=m Expression of COX-2 in normal and pyelonephritic kidney, renal intraepithelial neoplasia, and renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16543392&form=6&db=m Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor. unassigned -
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17284111&form=6&db=m Prognostic significance of CD44, platelet-derived growth factor receptor alpha, and cyclooxygenase 2 expression in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17899436&form=6&db=m Cyclooxygenase-2 expression: does it have a probable role in tumorigenesis mechanisms of renal cell carcinoma? diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18324478&form=6&db=m VEGF, COX-2, and PCNA expression in renal cell carcinoma subtypes and their prognostic value. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18384626&form=6&db=m The relationship between the local and systemic inflammatory responses and survival in patients undergoing resection for localized renal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18687532&form=6&db=m The clinical application of COX-2 inhibitors may strengthen the sensitivity of renal cell carcinoma to immunotherapy. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18786206&form=6&db=m Favorable response to combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor in metastatic renal cell carcinoma: Report of three cases. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021626&form=6&db=m The prognostic value of peritumoral regulatory T cells and its correlation with intratumoral cyclooxygenase-2 expression in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19351509&form=6&db=m [Expression of IGF-IR and COX-2 in renal cell carcinoma and their relationship with cell proliferation.] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19684042&form=6&db=m Multicenter Phase II Trial of Combination Therapy with Meloxicam, a COX-2 Inhibitor, and Natural Interferon-{alpha} for Metastatic Renal Cell Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20021866&form=6&db=m [Expression of COX-2 and VEGF and their correlation with angiogenesis in human clear cell renal cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20389170&form=6&db=m Enhancement of the sensitivity of renal cell carcinoma cells to fas-mediated cytotoxicity and apoptosis by the selective cyclooxygenase-2 inhibitor JTE-522. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20683050&form=6&db=m Prognostic evaluation of COX-2 expression in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20973869&form=6&db=m Phase-II trial of combination treatment of interferon-?, cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin-system inhibitor (I-CCA therapy) for advanced renal cell carcinoma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21086092&form=6&db=m Expression of C-reactive protein and cyclooxygenase enzyme-2 in clear cell renal cell carcinoma: correlation with pathological parameters in 110 patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21127751&form=6&db=m Relationship between arachidonic acid pathway and human renal cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21487892&form=6&db=m Clinical and Immunomodulatory Effects of Celecoxib Plus Interferon-Alpha in Metastatic Renal Cell Carcinoma Patients with COX-2 Tumor Immunostaining. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22289336&form=6&db=m Cox-2 gene overexpression in ureteral stump urothelial carcinoma following nephrectomy for renal cell carcinoma: a case report. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22343740&form=6&db=m [A case of favorable response after combination treatment with interferon-? and cyclooxygenase-2 inhibitor against metastatic renal cell carcinoma]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23110009&form=6&db=m Cyclooxygenase-2 expression and its prognostic significance in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23322198&form=6&db=m Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23886173&form=6&db=m Overexpression of cyclooxygenase-1 correlates with poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23931237&form=6&db=m Re: cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23946803&form=6&db=m ?-linolenic acid inhibits human renal cell carcinoma cell proliferation through PPAR-? activation and COX-2 inhibition. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25275044&form=6&db=m The role of functional polymorphisms of cyclooxygenase 2 in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25471032&form=6&db=m The role of prostaglandin E2 in renal cell cancer development: future implications for prognosis and therapy. unassigned -
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26060153&form=6&db=m Relationship of CD95 and COX-2 in renal cell carcinomas with survival and other prognostic parameters: A tissue microarray study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339385&form=6&db=m Combined use of COX-1 and VEGF immunohistochemistry refines the histopathologic prognosis of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26925639&form=6&db=m COX-2 Expression in Renal Cell Carcinoma and Correlations with Tumor Grade, Stage and Patient Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27578604&form=6&db=m Retrospective evaluation of COX-2 expression, histological and clinical factors as prognostic indicators in dogs with renal cell carcinomas undergoing nephrectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28117391&form=6&db=m Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib. causal interaction,diagnostic usage,unassigned 2,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28356937&form=6&db=m Resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580362&form=6&db=m Cyclooxygenase-2 expression in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423209&form=6&db=m Significance of cyclooxygenase-2, prostaglandin E2 and CD133 levels in sunitinib-resistant renal cell carcinoma. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751829&form=6&db=m The role of COX expression in the prognostication of overall survival of canine and feline cancer: A systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Signet Ring Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686777&form=6&db=m Expression of COX-2 in stomach cancers and its relation to their biological features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1571128&form=6&db=m Administration of a prostaglandin synthetase inhibitor associated with an increased immune cell infiltrate in squamous cell carcinoma of the head and neck. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3926297&form=6&db=m Biosynthesis of prostaglandins and hydroxy fatty acids in primary squamous carcinomas of head and neck in humans. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7646853&form=6&db=m Inhibition of growth of a murine squamous cell carcinoma by a cyclooxygenase inhibitor increases leukotriene B4 production. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8065730&form=6&db=m Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8612694&form=6&db=m Cyclooxygenases in human and mouse skin and cultured human keratinocytes: association of COX-2 expression with human keratinocyte differentiation. unassigned -
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9230197&form=6&db=m Retinoids suppress epidermal growth factor-induced transcription of cyclooxygenase-2 in human oral squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9247974&form=6&db=m Enhancement of prostaglandin E2 production by epidermal growth factor requires the coordinate activation of cytosolic phospholipase A2 and cyclooxygenase 2 in human squamous carcinoma A431 cells. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547657&form=6&db=m Tumor infiltrating lymphocytes in squamous cell carcinoma of the head and neck: mechanisms of enhancement using prostaglandin synthetase inhibitors. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635856&form=6&db=m COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766436&form=6&db=m Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823297&form=6&db=m Expression of cyclooxygenase-2 in human lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892207&form=6&db=m Cyclooxygenase-2 expression in human esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10070952&form=6&db=m Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10226539&form=6&db=m Expression of cyclooxygenase-2 in human squamous cell carcinoma of the esophagus; an immunohistochemical survey. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10506169&form=6&db=m Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10595745&form=6&db=m A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668483&form=6&db=m Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678579&form=6&db=m Molecular pathology of cyclooxygenase-2 in neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778945&form=6&db=m Up-regulation of cyclooxygenase-2 in squamous carcinogenesis of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10797288&form=6&db=m Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: evidence for growth suppression by inhibiting COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090967&form=6&db=m Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11140899&form=6&db=m Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11207687&form=6&db=m Bowen's disease (squamous cell carcinoma in situ) in immunosuppressed patients treated with imiquimod 5% cream and a cox inhibitor, sulindac: potential applications for this combination of immunotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245450&form=6&db=m Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297248&form=6&db=m Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11344234&form=6&db=m Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11381142&form=6&db=m Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401676&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in skin cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11410611&form=6&db=m Expression of cyclo-oxygenase-2 in naturally occurring squamous cell carcinomas in dogs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11587608&form=6&db=m Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor delta with head and neck squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605016&form=6&db=m Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11668514&form=6&db=m Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687951&form=6&db=m The growth of malignant keratinocytes depends on signaling through the PGE(2) receptor EP1. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745442&form=6&db=m Mn-SOD antisense upregulates in vivo apoptosis of squamous cell carcinoma cells by anticancer drugs and gamma-rays regulating expression of the BCL-2 family proteins, COX-2 and p21. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809691&form=6&db=m Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11810043&form=6&db=m Expression of cyclooxygenase-2 is associated with carcinogenesis of the lower part of thoracic esophageal squamous cell carcinoma and p53 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11823979&form=6&db=m Overexpression of cyclo-oxygenase 2 in squamous cell carcinoma of the hypopharynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11851614&form=6&db=m Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11953864&form=6&db=m Inhibitor of cyclooxygenase-2 induces cell-cycle arrest in the epithelial cancer cell line via up-regulation of cyclin dependent kinase inhibitor p21. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12013526&form=6&db=m The effect of betel nut extract on cell growth and prostaglandin endoperoxide synthase in human epidermoid carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070598&form=6&db=m Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126310&form=6&db=m Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164941&form=6&db=m Ketoconazole suppresses prostaglandin E(2)-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12174888&form=6&db=m Increased cyclooxygenase-2 expression in human squamous cell carcinomas of the head and neck and inhibition of proliferation by nonsteroidal anti-inflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196922&form=6&db=m Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203806&form=6&db=m Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209745&form=6&db=m Overexpression of cyclooxygenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12269772&form=6&db=m Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369871&form=6&db=m Selective cyclooxygenase-2 inhibitors and non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393863&form=6&db=m Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12408753&form=6&db=m Expression of inflammation related enzymes during experimental rat lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12445196&form=6&db=m Cyclooxygenase-2 inhibitor enhances whereas prostaglandin E2 inhibits the production of interferon-induced protein of 10 kDa in epidermoid carcinoma A431. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452059&form=6&db=m [A study on cyclooxygenase-2 protein expression and vasculature during experimental rat lung carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12459168&form=6&db=m Correlation between nitric oxide and cyclooxygenase-2 pathways in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12596063&form=6&db=m Expression of cyclo-oxygenase-2 is correlated with high intratumoral microvessel density and low apoptotic index in human esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648590&form=6&db=m High cyclooxygenase-2 expression in cervical adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738712&form=6&db=m Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12748469&form=6&db=m Expression of cyclooxygenase-2 in cervical, endometrial, and ovarian malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12870656&form=6&db=m Modulation of annexin I and cyclooxygenase-2 in smokeless tobacco-induced inflammation and oral cancer. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12874003&form=6&db=m Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12875991&form=6&db=m Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883661&form=6&db=m Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12893070&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in premalignant and malignant esophageal glandular and squamous lesions in Cixian, China. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895344&form=6&db=m [Overexpression of COX-2 and its clinical significance in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949405&form=6&db=m An immunohistochemical study of cyclooxygenase-2 expression in various feline neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954496&form=6&db=m Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957358&form=6&db=m Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958179&form=6&db=m Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12S-lipoxygenase and cyclooxygenase 1 in human epidermoid carcinoma A431 cells. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13679206&form=6&db=m Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14502644&form=6&db=m Inhibition of cutaneous ultraviolet light B-mediated inflammation and tumor formation with topical celecoxib treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532998&form=6&db=m Overexpression of cyclooxygenase-2 protein and its relationship to apoptosis in cervical carcinoma treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566822&form=6&db=m The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14626203&form=6&db=m Differential expression pattern of cyclooxygenase-1 and -2 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14630280&form=6&db=m NS 398 radiosensitizes an HNSCC cell line by possibly inhibiting radiation-induced expression of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14707443&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in human esophageal mucosa, dysplasia and carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871981&form=6&db=m Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14976535&form=6&db=m Biological behavior of keratoacanthoma and squamous cell carcinoma: telomerase activity and COX-2 as potential markers. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14977838&form=6&db=m Synchronous coexpression of epidermal growth factor receptor and cyclooxygenase-2 in carcinomas of the uterine cervix: a potential predictor of poor survival. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14989896&form=6&db=m [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15068324&form=6&db=m HER-2, EGFR, COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145696&form=6&db=m Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151617&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15173710&form=6&db=m Prognostic significance of vascular endothelial growth factor and cyclooxygenase 2 expression in patients receiving preoperative chemoradiation for esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179623&form=6&db=m COX-2 inhibition and lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15238218&form=6&db=m Essential role of c-Jun induction and coactivator p300 in epidermal growth factor-induced gene expression of cyclooxygenase-2 in human epidermoid carcinoma A431 cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15259059&form=6&db=m Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272284&form=6&db=m COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15287038&form=6&db=m Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355926&form=6&db=m Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458531&form=6&db=m Nonsteroidal anti-inflammatory drug use in the prevention and treatment of squamous cell carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15461861&form=6&db=m Cyclooxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465199&form=6&db=m Differential cyclooxygenase-2 expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15482327&form=6&db=m Nimesulide and indomethacin induce apoptosis in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491425&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499987&form=6&db=m [Expression of cyclooxygenase-2 and p53 and their correlation in carcinoma of larynx] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523901&form=6&db=m Sequential expression of inducible nitric oxide synthase and cyclooxygenase-2 during DMBA-induced hamster buccal pouch carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15587390&form=6&db=m Expression and significance of cyclooxygenase 2 gene in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15599594&form=6&db=m Expression of COX-2 and HER-2/neu and estrogen and progesterone receptor in primary squamous cell carcinomas of the endometrium. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625783&form=6&db=m Suppressive effects of a selective cyclooxygenase-2 inhibitor, etodolac, on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645120&form=6&db=m Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659778&form=6&db=m The cyclooxygenase inhibitor flurbiprofen reduces radiation-induced angiogenic growth factor secretion of squamous cell carcinoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701502&form=6&db=m Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15704107&form=6&db=m Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15844661&form=6&db=m Cyclooxygenase-2 induction and prostaglandin E2 accumulation in squamous cell carcinoma as a consequence of epidermal growth factor receptor activation by imatinib mesylate. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856454&form=6&db=m Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863127&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15936552&form=6&db=m Coexpression of cyclooxygenase-2 and thymidine phosphorylase as a prognostic indicator in patients with FIGO stage IIB squamous cell carcinoma of uterine cervix treated with radiotherapy and concurrent chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16027288&form=6&db=m A replication-selective adenoviral vector for head and neck cancers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16044407&form=6&db=m Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16046401&form=6&db=m T-oligo treatment decreases constitutive and UVB-induced COX-2 levels through p53- and NFkappaB-dependent repression of the COX-2 promoter. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055866&form=6&db=m COX-2 expression during early lung squamous cell carcinoma oncogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111807&form=6&db=m Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16144930&form=6&db=m Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16185283&form=6&db=m Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219633&form=6&db=m An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies. unassigned -
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16246405&form=6&db=m Prevalence and prognostic significance of COX-2 expression in stage IB cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16255988&form=6&db=m [Roles of cyclooxygenase-2 and caspase-3 expression in pathogenesis of lung carcinoma: an experiment with rats] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273222&form=6&db=m Expression of p63, COX-2, EGFR and beta-catenin in smokers and patients with squamous cell carcinoma of the head and neck reveal variations in non-neoplastic tissue and no obvious changes in smokers. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16279229&form=6&db=m [Cyclooxygenases in the skin] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337966&form=6&db=m Bile acid promotes the proliferation of squamous cell carcinoma of the esophagus, independent of its inducing COX-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424000&form=6&db=m Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525617&form=6&db=m [The antimicrobial effects of chitosans on oral pathogenic microbes in vitro.] ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552960&form=6&db=m [Ease-2 and inducible nitric oxide synthase in tongue hyperplasia and tongue squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16682957&form=6&db=m Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16700663&form=6&db=m Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16720448&form=6&db=m Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865247&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the oral cavity and pharynx: association to p53 and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16908593&form=6&db=m Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979845&form=6&db=m Cyclooxygenase-2 impairs treatment effects of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984531&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016639&form=6&db=m Elevated cell migration, invasion and tumorigenicity in human KB carcinoma cells transfected with COX-2 cDNA. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17108119&form=6&db=m Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17142201&form=6&db=m Prognostic factors and COX-2 expression in advanced stage esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17199422&form=6&db=m Expression of cyclooxygenase-1 and -2 in naturally occurring squamous cell carcinomas in horses. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220580&form=6&db=m Cyclo-oxygenase-2 over-expression is associated with human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17269882&form=6&db=m Immunohistochemical evaluation of cyclooxygenase expression in corneal squamous cell carcinoma in horses. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291249&form=6&db=m Cyclooxygenase-2 expression in cervical intraepithelial neoplasia III and squamous cell cervical carcinoma, and its correlation with clinicopathologic variables. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384145&form=6&db=m EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17387473&form=6&db=m Immune restoration in head and neck cancer patients after in vivo COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404023&form=6&db=m The cyclooxygenase-2 selective inhibitor celecoxib suppresses proliferation and invasiveness in the human oral squamous carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17416236&form=6&db=m Expression of Cox-1 and Cox-2 in canine mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17497299&form=6&db=m Expression of p63 and cyclooxygenase-2 and their correlation in skin tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17505004&form=6&db=m Enhancement of docetaxel-induced cytotoxicity by blocking epidermal growth factor receptor and cyclooxygenase-2 pathways in squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17511025&form=6&db=m Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560634&form=6&db=m The role of angiogenesis and COX-2 expression in the evolution of vulvar lichen sclerosus to squamous cell carcinoma of the vulva. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581404&form=6&db=m Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17617879&form=6&db=m Simultaneous adeno- and squamous cell carcinoma with different phenotypic profiles in a rat model of chronic gastroesophageal reflux. therapeutic application,unassigned 1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875728&form=6&db=m Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996482&form=6&db=m Expression of cyclooxygenase-2 and DNA topoisomerase II alpha in precancerous and cancerous lesions of the oral mucosa. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18027256&form=6&db=m Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058818&form=6&db=m The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18062281&form=6&db=m [The expression and significance of HIF-1alpha and COX-2 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18167181&form=6&db=m Aspirin inhibits the proliferation of tobacco-related esophageal squamous carcinomas cell lines through cyclooxygenase 2 pathway. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18186150&form=6&db=m COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202791&form=6&db=m Differential effects of selective cyclooxygenase-2 inhibitors in inhibiting proliferation and induction of apoptosis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18225538&form=6&db=m The effects of reactive species on the tumorigenic phenotype of human head and neck squamous cell carcinoma (HNSCC) cells. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18250037&form=6&db=m [Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18266822&form=6&db=m Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288396&form=6&db=m Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18330256&form=6&db=m [Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18356024&form=6&db=m Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446786&form=6&db=m Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18449376&form=6&db=m Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18467819&form=6&db=m Expression of cytosolic phospholipase A2 and cyclooxygenase 2 and their significance in human oral mucosae, dysplasias and squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18564172&form=6&db=m Effects of cyclooxygenase-2 non-selective and selective inhibitors on proliferation inhibition and apoptosis induction of esophageal squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18805045&form=6&db=m Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18977022&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the uterine cervix is associated with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19046264&form=6&db=m Expression of cyclooxygenase-2 by equine ocular and adnexal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19058955&form=6&db=m Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074839&form=6&db=m Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19123475&form=6&db=m Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138272&form=6&db=m Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cutaneous squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148897&form=6&db=m Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203995&form=6&db=m Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19229701&form=6&db=m Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287981&form=6&db=m Inhibitory effect of sulindac on DMBA-induced hamster cheek pouch carcinogenesis and its derived cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289704&form=6&db=m 7beta-hydroxycholesterol induces apoptosis and regulates cyclooxygenase 2 in head and neck squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19379196&form=6&db=m The effects of cyclooxygenase-2 inhibition on apoptosis and cell cycle distribution using two in vitro models of nasal squamous cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19391123&form=6&db=m DeltaNp63 isoforms differentially regulate gene expression in squamous cell carcinoma: identification of Cox-2 as a novel p63 target. unassigned -
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19558494&form=6&db=m Inhibition of 12-LOX and COX-2 reduces the proliferation of human epidermoid carcinoma cells (A431) by modulating the ERK and PI3K-Akt signalling pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19596931&form=6&db=m Discrepancies in expression and prognostic value of tumor markers in adenocarcinoma and squamous cell carcinoma in cervical cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630103&form=6&db=m Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737986&form=6&db=m Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19821125&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843689&form=6&db=m Elevated Levels of Urinary Prostaglandin E Metabolite Indicate a Poor Prognosis in Ever Smoker Head and Neck Squamous Cell Carcinoma Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19910795&form=6&db=m KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19923064&form=6&db=m [Inhibitory effects of COX-2 inhibitor on migration of human tongue squamous cell carcinoma Tca8113 cells] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19999807&form=6&db=m [Cyclooxygenase inhibitors in chemoprevention and treatment of esophageal squamous cell carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025602&form=6&db=m Dual EGFR and COX-2 inhibition as a novel approach to targeting head and neck squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034753&form=6&db=m Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20116423&form=6&db=m Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20121928&form=6&db=m c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192574&form=6&db=m Cyclooxygenase-2 Expression in Cervical Squamous Cell Carcinoma: the Significance of Expression in Neoplastic Cells within the Lymphovascular Space. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20222044&form=6&db=m Differential effects between cyclooxygenase-2 inhibitors and siRNA on vascular endothelial growth factor production in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20359903&form=6&db=m Aspirin and non-small cell lung cancer resections: effect on long-term survival. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20514441&form=6&db=m Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20558731&form=6&db=m Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592893&form=6&db=m Cox-2 and IL-10 polymorphisms and association with squamous cell carcinoma of the head and neck in a Korean sample. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635052&form=6&db=m [Expression of NF-kappaB and COX-2 in tongue squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20709621&form=6&db=m Inhibitive effect of celecoxib on the adhesion and invasion of human tongue squamous carcinoma cells to extracellular matrix via down regulation of MMP-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717005&form=6&db=m Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20951077&form=6&db=m A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115882&form=6&db=m Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21195874&form=6&db=m Prognostic cell biological markers in cervical cancer patients primarily treated with (chemo)radiation: a systematic review. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215004&form=6&db=m [Expression of COX-2 and its prognostic significance in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21251407&form=6&db=m [Study of COX-2 expression and angiogenesis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21255800&form=6&db=m Prognostic value of cyclooxygenase-2 expression in squamous cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21262157&form=6&db=m [Cyclooxygenase-2, inducible nitric oxide synthase protein expression and vasculature during experimental rat lung carcinogenesis.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21270615&form=6&db=m Clinicopathologic implications of the epidermal growth factor receptor, cyclooxygenase 2 expression, and human papillomavirus status in squamous cell carcinoma of the uterine cervix in the elderly. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21301321&form=6&db=m The influence of cyclooxygenase-1 expression on the efficacy of cyclooxygenase-2 inhibition in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21365830&form=6&db=m [Effect of cyclooxygenase-2 inhibitor on expression of matrix metalloproteinase-2 and invasion of tongue squamous cell carcinoma cell line Tca8113]. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21481000&form=6&db=m Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21572400&form=6&db=m Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21601872&form=6&db=m Immunohistochemical Detection of COX-2 in Feline and Canine Actinic Keratoses and Cutaneous Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656078&form=6&db=m The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21798652&form=6&db=m Cyclooxigenase-2 Levels are Increased in the Lung Tissue and Bronchial Tumors of Patients with Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22000259&form=6&db=m [Analysis of HIF-1? and COX-2 expression in tumor stroma and correlation with the degree of neoplasm invasiveness in laryngeal cancer--preliminary study]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038018&form=6&db=m Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22147962&form=6&db=m Effects of cyclooxygenase-2 on human esophageal squamous cell carcinoma. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159575&form=6&db=m Role of COX-2 activity and CRP levels in patients with non-melanoma skin cancer. -765G>C PTGS2 polymorphism and NMSC risk. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22372762&form=6&db=m Prognostic value of apoptotic markers in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22449077&form=6&db=m Isodesacetyluvaricin, an Annonaceous acetogenin, specifically inhibits gene expression of cyclooxygenase-2. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460809&form=6&db=m High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460857&form=6&db=m Epithelial to mesenchymal transition in cutaneous squamous cell carcinoma is correlated with COX-2 expression but not with the presence of stromal macrophages or CD10-expressing cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534023&form=6&db=m Pattern of expression of cyclooxygenase-2 in malignant transformation of sinonasal inverted papilloma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22627629&form=6&db=m The expression of p53 and COX-2 in basal cell carcinoma, squamous cell carcinoma and actinic keratosis cases. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22667343&form=6&db=m Immunohistochemical study of cyclooxygenase-2 in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22729746&form=6&db=m Prognostic significance of cyclooxygenase-2 in cervical cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23095338&form=6&db=m Significance of Cyclooxygenase 2, EZH-2 Polycomb Group and p53 Expression in Actinic Keratosis and Squamous Cell Carcinomas of the Skin. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23222816&form=6&db=m Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23261444&form=6&db=m The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23679684&form=6&db=m Effects of celecoxib treatment over the AKT pathway in head and neck squamous cell carcinoma. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23687559&form=6&db=m The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717003&form=6&db=m Up-regulation of cyclooxygenase 2 and matrix metalloproteinases-2 and -9 in cutaneous squamous cell carcinoma: active role of inflammation and tissue remodeling in carcinogenesis. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23774942&form=6&db=m A soft coral natural product, 11-episinulariolide acetate, inhibits gene expression of cyclooxygenase-2 and interleukin-8 through attenuation of calcium signaling. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851751&form=6&db=m Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23879794&form=6&db=m Expression of COX-1, COX-2 and mPGES-1 in penile and preputial papillomas and squamous cell carcinomas in the horse. diagnostic usage,unassigned 3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085777&form=6&db=m Chemoprevention of Head and Neck Cancer with Celecoxib and Erlotinib: Results of a Phase 1b and Pharmacokinetic Study. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24345644&form=6&db=m COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469308&form=6&db=m Cell-type-specific roles for COX-2 in UVB-induced skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469360&form=6&db=m Association between cyclooxygenase-2 gene polymorphisms and head and neck squamous cell carcinoma risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24639330&form=6&db=m Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene. causal interaction,unassigned 4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24692703&form=6&db=m Endoplasmic Reticulum Stress Response as a Possible Mechanism of Cyclooxygenase-2-independent Anticancer Effect of Celecoxib. ongoing research,unassigned 4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727329&form=6&db=m Erlotinib, erlotinib-sulindac vs. placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24887090&form=6&db=m Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25142993&form=6&db=m [Relationship between cyclooxygenase-2 in nasopharyngeal carcinoma and cervical lymph node metastasis]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25169079&form=6&db=m The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301050&form=6&db=m CXCR-4 and COX-2 Expression in Basal Cell Carcinomas and Well-Differentiated Squamous Cell Carcinomas of the Skin; Their Relationship with Tumor Invasiveness and Histological Subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25392182&form=6&db=m Difference in prognostic values of maximal standardized uptake value on fluorodeoxyglucose-positron emission tomography and cyclooxygenase-2 expression between lung adenocarcinoma and squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483152&form=6&db=m miR-26b is downregulated in human tongue squamous cell carcinoma and regulates cell proliferation and metastasis through a COX-2-dependent mechanism. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25575894&form=6&db=m Expression of Cyclooxygenase-2 in Squamous Cell Carcinoma and Keratoacanthoma and its Clinical Significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595899&form=6&db=m Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25724470&form=6&db=m Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26022894&form=6&db=m Comparative Expression of Apoptotic Markers in Lung Adenocarcinoma and Squamous Cell Carcinoma. diagnostic usage,therapeutic application,unassigned 1,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26568042&form=6&db=m Cyclooxygenase-2-1195G>A Polymorphism and Head and Neck Squamous Cell Carcinoma Susceptibility: A Meta-Analysis of 1564 Cases and 2346 Controls. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26960457&form=6&db=m The role of Ki-67, p16, CD34, Bcl-2, cyclooxygenase-2 in the pathogenesis of proliferative verrucous leukoplakia. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27012907&form=6&db=m Correlation Between Cyclo-oxygenase-2 and Vascular Endothelial Growth Factor Expression in Canine and Feline Squamous Cell Carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27292107&form=6&db=m Augmented Activity of Cyclooxygenase-2 in Tissue and Serum of Patients With Cervical Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27412115&form=6&db=m COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28230039&form=6&db=m Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489236&form=6&db=m Histologic correlation of VEGF and COX-2 expression with tumor size in squamous cell carcinoma of the larynx and hypopharynx. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28724634&form=6&db=m Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29279587&form=6&db=m Cyclooxygenase-2 (COX2) expression in adenocarcinoma surpasses that of squamous cell carcinoma in the uterine cervix. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29512696&form=6&db=m Identification of key genes and long non?coding RNAs in celecoxib?treated lung squamous cell carcinoma cell line by RNA?sequencing. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29904102&form=6&db=m Targeting PRPK and TOPK for skin cancer prevention and therapy. causal interaction,unassigned 1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087758&form=6&db=m Effect of Ferula persica plant methanol extract on the level of Cox-2 in induced squamous cell carcinoma (SCC) in rat tongue. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30270026&form=6&db=m Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer. ongoing research,unassigned 3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559850&form=6&db=m Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30900666&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31244433&form=6&db=m COX-2 Docking Structural Analysis with Phytochemical Extracts of Rosemary: A Possible Cytotoxicity on Head and Neck Squamous Cell Carcinoma Cell Line (HEp-2). diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31251418&form=6&db=m Expression of indolamine-2,3-dioxygenase and cyclooxygenase-2 in different disease stages of cutaneous squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31601050&form=6&db=m Mixed-Generation PAMAM G3-G0 Megamer as a Drug Delivery System for Nimesulide: Antitumor Activity of the Conjugate Against Human Squamous Carcinoma and Glioblastoma Cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32227417&form=6&db=m Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32235869&form=6&db=m New insights into the functions of Cox-2 in skin and esophageal malignancies. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655834&form=6&db=m miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33967512&form=6&db=m Immunohistochemical analysis and correlation of cyclooxygenase-2 expression status with clinicopathological parameters in head and neck squamous cell carcinomas: An Indian perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34084214&form=6&db=m Cyclooxygenase-2 expression is associated with chemoresistance through cancer stemness property in hypopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34320931&form=6&db=m Prediction of lymphovascular space invasion using a combination of tenascin-C, cox-2, and PET/CT radiomics in patients with early-stage cervical squamous cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582676&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10590224&form=6&db=m Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803639&form=6&db=m Expression of cyclooxygenase-2 in transitional cell carcinoma of the urinary bladder in dogs. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873095&form=6&db=m Cyclooxygenase-2 expression is up-regulated in transitional cell carcinoma and its preneoplastic lesions in the human urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238034&form=6&db=m Expression of cyclooxygenase-2 in human transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297248&form=6&db=m Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11443626&form=6&db=m Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809678&form=6&db=m Effects of the cyclooxygenase inhibitor, piroxicam, on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827414&form=6&db=m Expression of cyclooxygenase-1 and -2 in urinary bladder carcinomas in vivo and in vitro and prostaglandin E2 synthesis in cultured bladder cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12269772&form=6&db=m Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429306&form=6&db=m Association of cyclooxygenase-2 expression with prognosis of stage T1 grade 3 bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470662&form=6&db=m Cyclooxygenase-2 increased the angiogenic and metastatic potential of tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576817&form=6&db=m Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12589035&form=6&db=m Effects of the cyclooxygenase inhibitor, piroxicam, in combination with chemotherapy on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12614262&form=6&db=m Overexpression of cyclooxygenase-2 in high-grade human transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12913755&form=6&db=m Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949405&form=6&db=m An immunohistochemical study of cyclooxygenase-2 expression in various feline neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499687&form=6&db=m The expression of cyclooxygenase in transitional cell carcinoma cell lines: its correlation with tumor differentiation, invasiveness and prostanoids production. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566678&form=6&db=m Expression of cyclooxygenase-2 in primary superficial bladder cancer tissue may predict risk of its recurrence after complete transurethral resection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981815&form=6&db=m [Expression of cyclooxygenase in bladder transitional cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15450303&form=6&db=m Cyclooxygenase-2 parallels invasive depth and increased MVD in transitional cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498296&form=6&db=m [The significance of the expression of cyclooxygenase-2 in bladder transitional cell carcinoma tissues] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592025&form=6&db=m Expression of cyclooxygenase-2 and EP4 receptor in transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15664302&form=6&db=m Pretreatment tumor prostaglandin E2 concentration and cyclooxygenase-2 expression are not associated with the response of canine naturally occurring invasive urinary bladder cancer to cyclooxygenase inhibitor therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870865&form=6&db=m Cox-2 and Her2/neu co-expression in invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16132759&form=6&db=m Cyclooxygenase-2 expression increases with the stage and grade in transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16401921&form=6&db=m Relation between cyclooxygenase-2 expression and clinicopathologic parameters with patient prognosis in transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16573762&form=6&db=m Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966444&form=6&db=m Transitional Cell Carcinoma in Fishing Cats (Prionailurus viverrinus): Pathology and Expression of Cyclooxygenase-1, -2, and p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17024120&form=6&db=m The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17296438&form=6&db=m Expression of cyclooxygenase-2 in normal urothelium, and superficial and advanced transitional cell carcinoma of bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17316722&form=6&db=m Expression of cyclooxygenase-2, P-glycoprotein and multi-drug resistance-associated protein in canine transitional cell carcinoma. unassigned -
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18323852&form=6&db=m Expression-targeted gene therapy for the treatment of transitional cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18449376&form=6&db=m Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676844&form=6&db=m RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. diagnostic usage,unassigned 2,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19080686&form=6&db=m [Expression of cyclooxygenase-2 in bladder transitional cell carcinoma and the significance thereof] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19102503&form=6&db=m [Expressions of MMP-2 and COX-2 mRNA in bladder transitional cell carcinoma and their correlation] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287971&form=6&db=m Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428812&form=6&db=m Potential of molecular targeted therapy of HER-2 and Cox-2 for invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582552&form=6&db=m Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479487&form=6&db=m Cyclooxygenase-2 expression in invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21790228&form=6&db=m Expression of miR-143 Reduces Growth and Migration of Human Bladder Carcinoma Cells by Targeting Cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21985349&form=6&db=m Antitumor effects of deracoxib treatment in 26 dogs with transitional cell carcinoma of the urinary bladder. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22408147&form=6&db=m Clinical features, survival times and COX-1 and COX-2 expression in cats with transitional cell carcinoma of the urinary bladder treated with meloxicam. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23205923&form=6&db=m Randomized trial of cisplatin versus firocoxib versus cisplatin/firocoxib in dogs with transitional cell carcinoma of the urinary bladder. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23531445&form=6&db=m Molecular Imaging of Cyclooxygenase-2 in Canine Transitional Cell Carcinomas In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24083698&form=6&db=m Cyclooxygenase-2 Expression in Urinary Bladder Transitional Cell Carcinoma and its Association with Clinicopathological Characteristics. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28217972&form=6&db=m Clinical outcome of partial cystectomy for transitional cell carcinoma of the canine bladder. therapeutic application,unassigned 4,0
1.14.99.1 Carcinoma, Transitional Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30893857&form=6&db=m Correlation of BRAF Variant V595E, Breed, Histological Grade and Cyclooxygenase-2 Expression in Canine Transitional Cell Carcinomas. causal interaction,unassigned 4,0
1.14.99.1 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3918211&form=6&db=m Response of Walker 256 carcinosarcoma cells to 12-O-tetradecanoylphorbol 13-acetate: possible regulation by endogenous cyclooxygenase metabolites. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605037&form=6&db=m Cyclooxygenase-2 expression in malignant mesenchymal tumors and related uterine lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15589595&form=6&db=m COX-2, c-KIT and HER-2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15700850&form=6&db=m Cyclooxygenase-2 expression in uterine leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17416236&form=6&db=m Expression of Cox-1 and Cox-2 in canine mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19900134&form=6&db=m COX-2 expression in uterine carcinosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21412163&form=6&db=m Cyclooxygenase-2 Is an Independent Predictor of Poor Prognosis in Uterine Leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Carcinosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26222488&form=6&db=m The Effect of Cyclooxygenase-2 Expression in Uterine Carcinosarcoma on Survival: A Reassessment Based on Mature Data. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12586211&form=6&db=m Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27). causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358613&form=6&db=m Regulation of the membrane-localized prostaglandin E synthases mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15717837&form=6&db=m Effects of sodium restriction and cyclooxygenase-2 inhibition on the course of hypertension, proteinuria and cardiac hypertrophy in Ren-2 transgenic rats. ongoing research,unassigned 4,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15851630&form=6&db=m Cyclooxygenase-2 inhibitors attenuate angiotensin II-induced oxidative stress, hypertension, and cardiac hypertrophy in rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17198778&form=6&db=m Roles of cyclooxygenase-2 and phosphorylated Akt (Thr308) in cardiac hypertrophy regression mediated by left-ventricular unloading. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18180401&form=6&db=m Reduced cardiac remodeling and function in cardiac-specific EP4 receptor knockout mice with myocardial infarction. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20170663&form=6&db=m Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20339119&form=6&db=m MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20497423&form=6&db=m Celecoxib, but not rofecoxib or naproxen, attenuates cardiac hypertrophy and fibrosis induced in vitro by angiotensin and aldosterone. ongoing research,unassigned 2,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24291639&form=6&db=m COX-2 is involved in ET-1-induced hypertrophy of neonatal rat cardiomyocytes: role of NFATc3. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25846103&form=6&db=m Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25869400&form=6&db=m c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Cardiomegaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33748715&form=6&db=m Celecoxib alleviates pathological cardiac hypertrophy and fibrosis via M1-like macrophage infiltration in neonatal mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11352890&form=6&db=m Increased release of arachidonic acid and eicosanoids in iron-overloaded cardiomyocytes. unassigned -
1.14.99.1 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020525&form=6&db=m Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15023870&form=6&db=m Cyclooxygenase-2 inhibitor treatment improves left ventricular function and mortality in a murine model of doxorubicin-induced heart failure. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17334414&form=6&db=m Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy. unassigned -
1.14.99.1 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30102640&form=6&db=m Myocardial Redox Hormesis Protects the Heart of Female Mice in Sepsis. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679714&form=6&db=m Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21430081&form=6&db=m Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited DCM mouse model. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27628899&form=6&db=m 2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through GSK-3 activation. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31229551&form=6&db=m 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1332014&form=6&db=m Effects of cyclooxygenase and lipoxygenase inhibitors on digoxin-induced arrhythmias and haemodynamics in guinea-pigs. therapeutic application,unassigned 1,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15576013&form=6&db=m COX-2 selective inhibitors cardiac toxicity: getting to the heart of the matter. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15733024&form=6&db=m Do selective cyclo-oxygenase-2 inhibitors have a future? causal interaction,unassigned 4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16617129&form=6&db=m Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16670396&form=6&db=m Time variations in the risk of myocardial infarction among elderly users of COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17193179&form=6&db=m The furoxan system: design of selective nitric oxide (NO) donor inhibitors of COX-2 endowed with anti-aggregatory and vasodilating activities. unassigned -
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17335184&form=6&db=m NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17906437&form=6&db=m Cardiovascular effects of cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194278&form=6&db=m NSAIDs and breast cancer: a possible prevention and treatment strategy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18333314&form=6&db=m Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18705272&form=6&db=m An open prospective study on postmarketing evaluation of the efficacy and tolerability of diacerein in osteo-arthritis of the knee (DOK). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22394338&form=6&db=m Effect of selective and non-selective cyclooxygenase inhibitors on doxorubicin-induced cardiotoxicity and nephrotoxicity in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24658325&form=6&db=m TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25053391&form=6&db=m Modulatory effects of meloxicam on cardiotoxicity and antitumor activity of doxorubicin in mice. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26307959&form=6&db=m Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors. therapeutic application,unassigned 3,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26686322&form=6&db=m Chemoprevention of colorectal neoplasia. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27159981&form=6&db=m Phase II trial of weekly Docetaxel, Zoledronic acid, and Celecoxib for castration-resistant prostate cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28491485&form=6&db=m Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs: An Under-Recognized Public Health Issue. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30484341&form=6&db=m The COX-2/prostanoid signaling cascades in seizure disorders. causal interaction,unassigned 3,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30636337&form=6&db=m Nonaspirin Nonsteroidal Antiinflammatory Drug Use in the Nordic Countries from a Cardiovascular Risk Perspective, 2000-2016: A Drug Utilization Study. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31830546&form=6&db=m Chemoprotective role of an extract of the heart of the Phoenix dactylifera tree on adriamycin-induced cardiotoxicity and nephrotoxicity by regulating apoptosis, oxidative stress and PD-1 suppression. causal interaction,unassigned 1,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32111102&form=6&db=m Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion. therapeutic application,unassigned 4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32251635&form=6&db=m Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540642&form=6&db=m Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32895407&form=6&db=m Activated ROCK/Akt/eNOS and ET-1/ERK pathways in 5-fluorouracil-induced cardiotoxicity: modulation by simvastatin. diagnostic usage,unassigned 1,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485983&form=6&db=m A hybrid platform featuring nanomagnetic ligand fishing for discovering COX-2 selective inhibitors from aerial part of Saussurea laniceps Hand.-Mazz. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34373695&form=6&db=m Chitosan and Curcumin Nanoformulations against Potential Cardiac Risks Associated with Hydroxyapatite Nanoparticles in Wistar Male Rats. diagnostic usage,unassigned 2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8838113&form=6&db=m [Molecular pharmacology and application to the bronchial asthma of thromboxane A2 antagonists] causal interaction,unassigned 1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10942685&form=6&db=m Expression of cyclo-oxygenase-2 in human atherosclerotic carotid arteries. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11405554&form=6&db=m Release of tumor necrosis factor-alpha and prostanoids in whole blood cultures after in vivo exposure to low-dose aspirin. causal interaction,unassigned 3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12005203&form=6&db=m Antithrombotic and platelet function inhibiting effects of ML3000, a new antiinflammatory drug with Cox/5-LOX inhibitory activity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12241124&form=6&db=m Selective cyclo-oxygenase-2 inhibitors and myocardial infarction: how strong is the link? causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12389824&form=6&db=m COX-2 inhibitors in the treatment of cardiovascular disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12389825&form=6&db=m COX-2 inhibitors in the treatment of cardiovascular disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12528099&form=6&db=m Selective cyclooxygenase 2 inhibitors, aspirin, and cardiovascular disease: a reappraisal. therapeutic application,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12551863&form=6&db=m Selective COX-2 inhibition improves endothelial function in coronary artery disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12582422&form=6&db=m The basis for the chemopreventive action of resveratrol. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616850&form=6&db=m COX-2 selective non-steroidal anti-inflammatory drugs and cardiovascular disease. therapeutic application,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12640241&form=6&db=m Do COX-2 inhibitors really prevent hypertension and proteinuria? Another brick in the wall for the COX-2 inhibition and cardiovascular disease controversy. therapeutic application,unassigned 3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679220&form=6&db=m Effect of aspirin on late preconditioning against myocardial stunning in conscious rabbits. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12818730&form=6&db=m Role of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors, angiotensin-converting enzyme inhibitors, cyclooxygenase-2 inhibitors, and aspirin in anti-inflammatory and immunomodulatory treatment of cardiovascular diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597594&form=6&db=m Differential effects of selective cyclooxygenase-2 inhibitors on endothelial function in salt-induced hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623265&form=6&db=m Effect of nitric oxide-donating agents on human monocyte cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020596&form=6&db=m Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15061569&form=6&db=m Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151474&form=6&db=m Cardiovascular effects of selective cyclooxygenase-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15170590&form=6&db=m Cyclooxygenase and 5-lipoxygenase pathways in the vessel wall: role in atherosclerosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15225597&form=6&db=m Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355747&form=6&db=m Aspirin, NSAIDs, and COX-2 inhibitors in cardiovascular disease: possible interactions and implications for treatment of rheumatoid arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385947&form=6&db=m Cardiovascular risk and COX-2 inhibition in rheumatological practice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15528468&form=6&db=m Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15530895&form=6&db=m Sulfone COX-2 inhibitors increase susceptibility of human LDL and plasma to oxidative modification: comparison to sulfonamide COX-2 inhibitors and NSAIDs. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15550624&form=6&db=m COX-2-derived prostacyclin confers atheroprotection on female mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681294&form=6&db=m Transcriptional Control of COX-2 via C/EBPbeta. unassigned -
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683587&form=6&db=m Anti-inflammatory strategies in hypertension: focus on COX-1 and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15755796&form=6&db=m Factors associated with celecoxib and rofecoxib utilization. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15789774&form=6&db=m [VIOXX written off--and what next? COX-2 inhibitors and cardiovascular diseases] therapeutic application,unassigned 2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15790928&form=6&db=m Oxidative enzymopathies and vascular disease. causal interaction,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15795326&form=6&db=m Celecoxib decreases endothelial tissue factor expression through inhibition of c-Jun terminal NH2 kinase phosphorylation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15851630&form=6&db=m Cyclooxygenase-2 inhibitors attenuate angiotensin II-induced oxidative stress, hypertension, and cardiac hypertrophy in rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127636&form=6&db=m COX-2 inhibitors--IBC conference. 12-13 April 1999, Coronado, CA, USA. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16150050&form=6&db=m Cyclooxygenase-1 haplotype modulates platelet response to aspirin. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16179345&form=6&db=m Aspirin induces platelet receptor shedding via ADAM17 (TACE). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16190133&form=6&db=m Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16220041&form=6&db=m Cyclooxygenase-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273175&form=6&db=m COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16297879&form=6&db=m eNOS, COX-2, and prostacyclin production are impaired in endothelial cells from diabetics. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16330117&form=6&db=m Divergent effects of rofecoxib on endothelial function and inflammation in acute coronary syndromes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16335308&form=6&db=m [Do selective COX-2 inhibitors have adverse renal and cardiovascular effects?] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16458279&form=6&db=m Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16484611&form=6&db=m De novo synthesis of cyclooxygenase-1 counteracts the suppression of platelet thromboxane biosynthesis by aspirin. causal interaction,unassigned 3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16499546&form=6&db=m Age and rising rates of cyclooxygenase-2 inhibitor use. Results from a national survey. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510063&form=6&db=m When should COX-2 selective NSAIDs be used for osteoarthritis and rheumatoid arthritis? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16604526&form=6&db=m Transgenic mouse for conditional, tissue-specific Cox-2 overexpression. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627818&form=6&db=m COX-2 in cardiovascular disease. unassigned -
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785336&form=6&db=m Risk of death or reinfarction associated with the use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflammatory drugs after acute myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16879213&form=6&db=m Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892400&form=6&db=m Detection of Overexpressed COX-2 in Precancerous Lesions of Hamster Pancreas and Lungs by Molecular Imaging: Implications for Early Diagnosis and Prevention. causal interaction,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16904555&form=6&db=m Cyclooxygenase-2 inhibitors enhance shear stress-induced platelet aggregation. causal interaction,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17073588&form=6&db=m Cyclooxygenase inhibition and atherothrombosis. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17279220&form=6&db=m Gastroprotective strategies among NSAID users: guidelines for appropriate use in chronic illness. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17495879&form=6&db=m Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17544386&form=6&db=m Biochemistry of protein tyrosine nitration in cardiovascular pathology. unassigned -
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612044&form=6&db=m Anti-inflammatory drugs in the 21st century. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645304&form=6&db=m Upregulation of cyclooxygenase-2 by motorcycle exhaust particulate-induced reactive oxygen species enhances rat vascular smooth muscle cell proliferation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17993511&form=6&db=m Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18092115&form=6&db=m A case of takotsubo cardiomyopathy precipitated by lumiracoxib, a selective COX-2 inhibitor. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18158501&form=6&db=m Use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflammatory drugs in high doses increases mortality and risk of reinfarction in patients with prior myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18185149&form=6&db=m Use of cox-2 inhibitors in patients with retinal venous occlusive disease. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18221099&form=6&db=m The role of angiotensin type 1 receptor in inflammation and endothelial dysfunction. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18263647&form=6&db=m What is the harm-benefit ratio of Cox-2 inhibitors? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18287589&form=6&db=m Cyclooxygenase-2 inhibitors and most traditional nonsteroidal anti-inflammatory drugs cause similar moderately increased risks of cardiovascular disease. therapeutic application,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18323528&form=6&db=m Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18333314&form=6&db=m Nimesulide is a selective COX-2 inhibitory, atypical non-steroidal anti-inflammatory drug. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18356636&form=6&db=m Extended-Release Tramadol (ULTRAM(R)ER): A Pharmacotherapeutic, Pharmacokinetic, and Pharmacodynamic Focus on Effectiveness and Safety in Patients with Chronic/Persistent Pain. therapeutic application,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18373616&form=6&db=m Diabetes, colorectal cancer and cyclooxygenase 2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18505582&form=6&db=m Nitric oxide pathway-mediated relaxant effect of aqueous sesame leaves extract (Sesamum radiatum Schum. & Thonn.) in the guinea-pig isolated aorta smooth muscle. unassigned -
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18514659&form=6&db=m Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18668605&form=6&db=m Subgroup analyses to determine cardiovascular risk associated with nonsteroidal antiinflammatory drugs and coxibs in specific patient groups. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18668614&form=6&db=m Changes in the characteristics of patients prescribed selective cyclooxygenase 2 inhibitors after the 2004 withdrawal of rofecoxib. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18673161&form=6&db=m Impact of traditional therapies and biologics on cardiovascular diseases in rheumatoid arthritis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18768181&form=6&db=m Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18948273&form=6&db=m Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19091535&form=6&db=m A polymorphism in the cyclooxygenase 1 gene is associated with decreased inflammatory prostaglandin F2alpha formation and lower risk of cardiovascular disease. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19327107&form=6&db=m Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336727&form=6&db=m Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19340409&form=6&db=m Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19373083&form=6&db=m Molecular mechanisms underlying the antiatherosclerotic and antidiabetic effects of probucol, succinobucol, and other probucol analogues. therapeutic application,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19413182&form=6&db=m Non-steroidal anti-inflammatory drugs and the risk of cardiovascular diseases: are we going to see the revival of cyclooxygenase-2 selective inhibitors? causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19556450&form=6&db=m Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19625268&form=6&db=m The Influence of COX-2 Single Nucleotide Polymorphisms on Abdominal Aortic Aneurysm Development and the Associated Inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19654224&form=6&db=m An ion channel hypothesis to explain divergent cardiovascular safety of COX-2 inhibitors: the answer to a hotly-debated puzzle? (Relates to article by Brueggemann, et al., Fast Forward 15 July 2009). therapeutic application,unassigned 3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19748096&form=6&db=m Cox-2 polymorphisms and cardiovascular disease: Elucidating the hidden side of the disease. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19762092&form=6&db=m Precaution, cyclooxygenase inhibition, and cardiovascular risk. causal interaction,unassigned 3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20477620&form=6&db=m Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20539104&form=6&db=m Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale. therapeutic application,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20583136&form=6&db=m Mechanisms of adiponectin-mediated COX-2 induction and protection against iron injury in mouse hepatocytes. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20837537&form=6&db=m Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20941937&form=6&db=m [Nonsteroidal anti-inflammatory drugs and the risk of cardiovascular diseases]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21114363&form=6&db=m A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy. unassigned -
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21147199&form=6&db=m Cigarette smoking, cyclooxygenase-2 pathway and cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22119250&form=6&db=m Cyclooxygenase-2 and kidney failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22434418&form=6&db=m Eicosanoids and Their Drugs in Cardiovascular Diseases: Focus on Atherosclerosis and Stroke. causal interaction,unassigned 2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22711755&form=6&db=m Cox-2 inhibitors and cardiovascular disease: considerable heat, but not much light. therapeutic application,unassigned 3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23030452&form=6&db=m Cyclooxygenase-2 expression, prostacyclin production and endothelial protection of high-density lipoprotein. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23038044&form=6&db=m Frequency, risk factors, prognosis, and genetic polymorphism of the cyclooxygenase-1 gene for aspirin resistance in elderly chinese patients with cardiovascular disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23475595&form=6&db=m Amelioration of Cholesterol Induced Atherosclerosis by Normalizing Gene Expression, Cholesterol Profile and Antioxidant Enzymes by Vigna unguiculata. unassigned -
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23682075&form=6&db=m Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers. causal interaction,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23993980&form=6&db=m Mechanisms of aspirin resistance. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24502626&form=6&db=m Cardiovascular risks of cyclooxygenase-2 inhibitors and traditional anti-inflammatory drugs: necessary but not sufficient for clinical decision making. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24748925&form=6&db=m Platelet thromboxane (11-dehydro-Thromboxane B2) and aspirin response in patients with diabetes and coronary artery disease. causal interaction,unassigned 2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24796340&form=6&db=m Association of cyclooxygenase-2 genetic variant with cardiovascular disease. causal interaction,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24902855&form=6&db=m PAR1-dependent COX-2/PGE2 production contributes to cell proliferation via EP2 receptors in primary human cardiomyocytes. causal interaction,unassigned 2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25869400&form=6&db=m c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25888188&form=6&db=m Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes. causal interaction,unassigned 4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26511468&form=6&db=m Update on SAR Studies Toward New COX-1 Selective Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26517138&form=6&db=m The Implication of the Polymorphisms of COX-1, UGT1A6, and CYP2C9 among Cardiovascular Disease (CVD) Patients Treated with Aspirin. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26747234&form=6&db=m Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27159620&form=6&db=m Microsomal Prostaglandin E Synthase-1 Expression by Aortic Smooth Muscle Cells Attenuates the Differentiated Phenotype. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27317138&form=6&db=m Cardiovascular effects of cyclooxygenase-2 inhibitors: a mechanistic and clinical perspective. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27566955&form=6&db=m Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713681&form=6&db=m Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease. diagnostic usage,unassigned 2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056333&form=6&db=m [Recommendation for the prevention and treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal ulcers and its complications]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28163951&form=6&db=m A Review on the Relationship between Aspirin and Bone Health. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28699682&form=6&db=m 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin promotes endothelial cell apoptosis through activation of EP3/p38MAPK/Bcl-2 pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28844979&form=6&db=m Tailoring naringenin conjugates with amplified and triple antiplatelet activity profile: Rational design, synthesis, human plasma stability and in vitro evaluation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29309904&form=6&db=m Regulator of calcineurin 1 modulates vascular contractility and stiffness through the upregulation of COX-2-derived prostanoids. unassigned -
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30069194&form=6&db=m Does the timing of aspirin administration influence its antiplatelet effect - review of literature on chronotherapy. causal interaction,unassigned 1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30176739&form=6&db=m Benefits and Risks of Nonsteroidal Anti-inflammatory Drugs: Methodologic Limitations Lead to Clinical Uncertainties. unassigned -
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30325206&form=6&db=m Natural products and their derivatives as cyclooxygenase-2 inhibitors. causal interaction,unassigned 3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30771282&form=6&db=m Characterization of aspirin esterase activity in health and disease: In vitro and ex vivo studies. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30875493&form=6&db=m Celecoxib aggravates atherogenesis and upregulates leukotrienes in ApoE-/- mice and lipopolysaccharide-stimulated RAW264.7 macrophages. causal interaction,unassigned 2,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31878351&form=6&db=m Untargeted Metabolomics to Go beyond the Canonical Effect of Acetylsalicylic Acid. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32323554&form=6&db=m Interplay Between Oxidative Stress, Cyclooxygenases, and Prostanoids in Cardiovascular Diseases. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679712&form=6&db=m Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33110169&form=6&db=m NSAIDs-dependent adaption of the mitochondria-proteasome system in immortalized human cardiomyocytes. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33658823&form=6&db=m Distinctive Under-Expression Profile of Inflammatory and Redox Genes in the Blood of Elderly Patients with Cardiovascular Disease. unassigned -
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34309807&form=6&db=m Non-steroidal Anti-inflammatory Drug Use and Risk of Age-Related Macular Degeneration in the California Teachers Study. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Cardiovascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34369277&form=6&db=m Formononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-? signaling based on network pharmacology and experimental validation. unassigned -
1.14.99.1 Carotid Artery Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16212965&form=6&db=m Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Carotid Artery Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367682&form=6&db=m Arterial Thrombosis Is Accompanied by Elevated Mitogen-Activated Protein Kinase (MAPK) and Cyclooxygenase-2 (COX-2) Expression via Toll-Like Receptor 4 (TLR-4) Activation by S100A8/A9. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065323&form=6&db=m Platelet phagocytosis and processing of beta-amyloid precursor protein as a mechanism of macrophage activation in atherosclerosis. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16212965&form=6&db=m Overexpression of COX-2, Prostaglandin E synthase-1 and prostaglandin E receptors in blood mononuclear cells and plaque of patients with carotid atherosclerosis: regulation by nuclear factor-kappaB. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Carotid Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17543677&form=6&db=m Aspirin resistance among long-term aspirin users after carotid endarterectomy and controls: flow cytometric measurement of aspirin-induced platelet inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Carpal Tunnel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14663224&form=6&db=m COX-2 up-regulation in idiopathic carpal tunnel syndrome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6409656&form=6&db=m Effect of prostaglandin synthetase inhibitors on non-analgesic actions of morphine. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6912578&form=6&db=m Participation of prostaglandins in the action of kinins on the central dopaminergic system in the rat. I. The action of kinins on the central dopaminergic system after pretreatment with indomethacin. ongoing research,unassigned 2,0
1.14.99.1 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12206852&form=6&db=m Cyclooxygenase inhibitor modulation of dopamine-related behaviours. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369252&form=6&db=m Differential effects of cyclooxygenase inhibitors on haloperidol-induced catalepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24995576&form=6&db=m CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson's disease mice. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Catalepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29516413&form=6&db=m Interplay between adenosine receptor antagonist and cyclooxygenase inhibitor in haloperidol-induced extrapyramidal effects in mice. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1841575&form=6&db=m Role of interleukin 6 in the inflammatory response after cataract surgery. An experimental and clinical study. causal interaction,unassigned 3,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2106819&form=6&db=m Topical flurbiprofen in intraocular surgery on diabetic and nondiabetic patients. ongoing research,unassigned 2,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8229720&form=6&db=m Topical flurbiprofen in extracapsular cataract surgery: effect on pupillary diameter and iris fluorescein leakage. therapeutic application,unassigned 4,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8675396&form=6&db=m The role of prostaglandins E2 and F2 alpha in ultraviolet radiation-induced cortical cataracts in vivo. causal interaction,unassigned 4,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713817&form=6&db=m Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16105620&form=6&db=m Cyclooxygenase-2 inhibitors: a new therapeutic option in the treatment of macular edema after cataract surgery. therapeutic application,unassigned 4,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16626425&form=6&db=m Correlations between optical coherence tomography measurement of macular thickness and visual acuity after cataract extraction. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17397743&form=6&db=m Successful treatment of cystoid macular edema with valdecoxib. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17563718&form=6&db=m Prevention of posterior capsular opacification through cyclooxygenase-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20373895&form=6&db=m Aqueous humor endothelin-1 (Et-1), vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) levels in Mexican glaucomatous patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636042&form=6&db=m Efficacy of COX-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removal. therapeutic application,unassigned 3,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26990912&form=6&db=m Comparison of topically applied flurbiprofen or bromfenac ophthalmic solution on post-operative ocular hypertension in canine patients following cataract surgery. therapeutic application,unassigned 4,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29269999&form=6&db=m Topical nepafenac for prevention of post-cataract surgery macular edema in diabetic patients: patient selection and perspectives. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29660334&form=6&db=m Fatty acids modulate the efficacy of lutein in cataract prevention: Assessment of oxidative and inflammatory parameters in rats. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Cataract http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640796&form=6&db=m Cyanidin-3-O-glucoside Protects Lens Epithelial Cells against High Glucose-Induced Apoptosis and Prevents Cataract Formation via Suppressing NF-?B Activation and Cox-2 Expression. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Catatonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19666045&form=6&db=m Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats. ongoing research,unassigned 2,0
1.14.99.1 Catatonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24250457&form=6&db=m Selective cyclooxygenase-2 inhibitor compound 11b improves haloperidol-induced catatonia by enhancing the striatum dopaminergic neurotransmission. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Catatonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24381603&form=6&db=m The selective cyclooxygenase-2 inhibitor, the compound 11b improves haloperidol induced catatonia by enhancing the striatum dopaminergic neurotransmission. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Celiac Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30794064&form=6&db=m A Peptide from Kiwifruit Exerts Anti-Inflammatory Effects in Celiac Disease Mucosa. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Cell Transformation, Neoplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9261162&form=6&db=m Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 overexpression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Cell Transformation, Neoplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278747&form=6&db=m Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Cell Transformation, Neoplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688410&form=6&db=m Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Cell Transformation, Neoplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25787879&form=6&db=m Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10078970&form=6&db=m Upregulation of COX-2 and CGRP expression in resident cells of the Borna disease virus-infected brain is dependent upon inflammation. causal interaction,unassigned 4,0
1.14.99.1 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12707081&form=6&db=m Cyclooxygenases in central nervous system diseases: a special role for cyclooxygenase 2 in neuronal cell death. unassigned -
1.14.99.1 Central Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20868723&form=6&db=m Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cerebral Cortical Thinning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26984955&form=6&db=m COX-2 gene dosage dependent defects in kidney development. causal interaction,unassigned 2,0
1.14.99.1 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11368948&form=6&db=m Inducible cyclooxygenase-2 expression after experimental intracerebral hemorrhage. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362723&form=6&db=m Celecoxib induces functional recovery after intracerebral hemorrhage with reduction of brain edema and perihematomal cell death. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17123715&form=6&db=m Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage. therapeutic application,unassigned 4,0
1.14.99.1 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21816595&form=6&db=m A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population. diagnostic usage,unassigned 1,0
1.14.99.1 Cerebral Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32676872&form=6&db=m History of Nonsteroidal Anti-inflammatory Drug Use and Functional Outcomes After Spontaneous Intracerebral Hemorrhage. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651024&form=6&db=m Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10867793&form=6&db=m Selective accumulation of cyclooxygenase-1-expressing microglial cells/macrophages in lesions of human focal cerebral ischemia. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11997284&form=6&db=m Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12475019&form=6&db=m Overactive bladder--experimental aspects. unassigned -
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891667&form=6&db=m Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15064140&form=6&db=m Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15656909&form=6&db=m Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947691&form=6&db=m Role of cyclooxygenase-2 in the development of bladder overactivity after cerebral infarction in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17271370&form=6&db=m Melatonin reduced volume of cerebral infarct induced by photothrombosis in wild-type mice, not in Cyclooxygenase-1 gene knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20022033&form=6&db=m Improvement in neurogenic detrusor overactivity by peripheral C fiber's suppression with cyclooxygenase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025014&form=6&db=m Pharmacological and genetic analysis of mechanisms underlying detrusor overactivity in rats. unassigned -
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20083630&form=6&db=m SO2 inhalation contributes to the development and progression of ischemic stroke in the brain. unassigned -
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21075387&form=6&db=m Modulation of stretch evoked adenosine triphosphate release from bladder epithelium by prostaglandin E?. causal interaction,unassigned 2,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23626659&form=6&db=m Splenic Immune Cells In Experimental Neonatal Hypoxia-Ischemia. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Cerebral Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34419138&form=6&db=m Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Cerebral Palsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26781425&form=6&db=m COX-1 and COX-2 polymorphisms in susceptibility to cerebral palsy in very preterm infants. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Cerebral Small Vessel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852948&form=6&db=m Cyclooxygenase 2 genetic polymorphism may increase the risk of developing leukoaraiosis in chinese. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Cerebral Small Vessel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26159203&form=6&db=m A Cyclooxygenase-2 Inhibitor Reduces Vascular Wall Thickness and Ameliorates Cognitive Impairment in a Cerebral Small Vessel Diseases Rat Model. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6810497&form=6&db=m A study of hemostasis in ischemic cerebrovascular disease. II. Abnormalities in platelet ADP release, platelet cyclooxygenase regeneration time and platelet factor 3 availability. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647575&form=6&db=m -New aspects in antithrombotic therapy--platelet inhibitors-. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10380963&form=6&db=m A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10651024&form=6&db=m Cyclooxygenase-2 is induced in microglia during chronic cerebral ischemia in humans. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11571316&form=6&db=m Marked increase in cyclooxygenase-2 in ALS spinal cord: implications for therapy. diagnostic usage,unassigned 4,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12047458&form=6&db=m COX-2 inhibitor for the treatment of idiopathic stabbing headache secondary to cerebrovascular diseases. therapeutic application,unassigned 4,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891667&form=6&db=m Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16479190&form=6&db=m The COX-2 G/C -765 polymorphism may modulate the occurrence of cerebrovascular ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17054845&form=6&db=m [Risk factor assessment of cardiocerebrovascular diseases in patients with rheumatoid arthritis] causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19033684&form=6&db=m Cyclo-oxygenase-2 -765G > C promoter variants are associated with lower carotid plaque echogenicity in Japanese. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19741338&form=6&db=m Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in humans. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25957909&form=6&db=m COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1
1.14.99.1 Cerebrovascular Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27033056&form=6&db=m Misoprostol reverse hippocampal neuron cyclooxygenase-2 downstream signaling imbalance in aluminum-overload rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11234900&form=6&db=m Cyclooxygenase-2 is overexpressed in human cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15790444&form=6&db=m The expression of cyclooxygenase-2, VEGF and PGs in CIN and cervical carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863127&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16188370&form=6&db=m The cyclooxygenase-2 inhibitor rofecoxib (Vioxx) in the treatment of cervical dysplasia grade II-III A phase II trial. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291249&form=6&db=m Cyclooxygenase-2 expression in cervical intraepithelial neoplasia III and squamous cell cervical carcinoma, and its correlation with clinicopathologic variables. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17415111&form=6&db=m Cyclooxygenase 2 expression in cervical intraepithelial neoplasia and vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18275990&form=6&db=m Cyclooxygenase-2 in cervical neoplasia: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723044&form=6&db=m Cyclooxygenase-2 expression in cervical intraepithelial neoplasia. ongoing research,unassigned 4,0
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530431&form=6&db=m Increased serum progesterone and estradiol correlate to increased COX-2 tissue expression in cervical intraepithelial neoplasia. diagnostic usage,unassigned 1,0
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675067&form=6&db=m Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681731&form=6&db=m Cox-2, EGFR, and ERBB-2 Expression in Cervical Intraepithelial Neoplasia and Cervical Cancer Using an Automated Imaging System. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27292107&form=6&db=m Augmented Activity of Cyclooxygenase-2 in Tissue and Serum of Patients With Cervical Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Cervical Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599442&form=6&db=m Promoter methylation status of the tumor suppressor genes p16 and cadherin 1 in cervical intraepithelial neoplasia. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10646605&form=6&db=m Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15545053&form=6&db=m Circulating levels of cyclooxygenase metabolites in experimental Trypanosoma cruzi infections. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15864778&form=6&db=m Depletion of immature B cells during Trypanosoma cruzi infection: involvement of myeloid cells and the cyclooxygenase pathway. ongoing research,unassigned 4,0
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16009364&form=6&db=m Inducible cyclooxygenase released prostaglandin mediates immunosuppression in acute phase of experimental Trypanosoma cruzi infection. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18031539&form=6&db=m Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18163990&form=6&db=m Trypanosoma cruzi: The role of PGE2 in immune response during the acute phase of experimental infection. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23681190&form=6&db=m Protection of vascular endothelium by aspirin in a murine model of chronic Chagas' disease. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25092706&form=6&db=m Inhibition of cyclooxygenase-1 and cyclooxygenase-2 impairs Trypanosoma cruzi entry into cardiac cells and promotes differential modulation of the inflammatory response. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25957909&form=6&db=m COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26305786&form=6&db=m Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Chagas Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26485277&form=6&db=m Correction: Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Cheilitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18674950&form=6&db=m Actinic cheilitis: Epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Cheilitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21689160&form=6&db=m Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression. ongoing research,unassigned 1,0
1.14.99.1 Chemical and Drug Induced Liver Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11743745&form=6&db=m A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Chemical and Drug Induced Liver Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16518289&form=6&db=m Prolonged cholestasis associated with short-term use of celecoxib. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Chlamydia Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19109220&form=6&db=m Chlamydia infection causes loss of pacemaker cells and inhibits oocyte transport in the mouse oviduct. causal interaction,unassigned 4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115827&form=6&db=m Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11870367&form=6&db=m COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11910351&form=6&db=m Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12143044&form=6&db=m Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12143054&form=6&db=m ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12213730&form=6&db=m Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12360423&form=6&db=m Cyclooxygenase-2 and ERBB-2 in cholangiocarcinoma: potential therapeutic targets. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12508379&form=6&db=m Proliferative activity of bile from congenital choledochal cyst patients. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12654561&form=6&db=m Development of a therapeutic adenoviral vector for cholangiocarcinoma combining tumor-restricted gene expression and infectivity enhancement. unassigned -
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12717864&form=6&db=m Bile from a patient with anomalous pancreaticobiliary ductal union promotes the proliferation of human cholangiocarcinoma cells via COX-2 pathway. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12800245&form=6&db=m Celecoxib inhibits proliferation and induces apoptosis via prostaglandin E2 pathway in human cholangiocarcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607721&form=6&db=m Expression of cyclooxygenase-1 and -2 in extra-hepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678698&form=6&db=m [Role of cyclooxygenase-2 in the pathogenesis of chronic liver diseases] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14973068&form=6&db=m Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999691&form=6&db=m Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026550&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057907&form=6&db=m Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation. ongoing research,unassigned 3,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15086604&form=6&db=m Expression of cyclooxygenase-2 in cholangiocarcinoma: correlation with clinicopathological features and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15250241&form=6&db=m Effects of cyclooxygenase-2 antisense vector on proliferation of human cholangiocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15519654&form=6&db=m Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15690474&form=6&db=m Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. unassigned -
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15855163&form=6&db=m Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15921858&form=6&db=m Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966336&form=6&db=m A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984600&form=6&db=m Akt expression may predict favorable prognosis in cholangiocarcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17165088&form=6&db=m Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159174&form=6&db=m [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199552&form=6&db=m Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18507031&form=6&db=m Prognostic value of eicosanoid pathways in extrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18854271&form=6&db=m Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19066964&form=6&db=m Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19084911&form=6&db=m Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173916&form=6&db=m [Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma] diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218340&form=6&db=m Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19621664&form=6&db=m Expression of c-erbB-2 and cyclooxygenase-2 in intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22131058&form=6&db=m Immunodetection of cyclooxygenase-2 (COX-2) is restricted to tissue macrophages in normal rat liver and to recruited mononuclear phagocytes in liver injury and cholangiocarcinoma. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23260331&form=6&db=m Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23608225&form=6&db=m miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF). causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24699315&form=6&db=m MiR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26125824&form=6&db=m Expression of COX-2 and VEGF-C in cholangiocarcinomas at different clinical and pathological stages. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26518876&form=6&db=m Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26718397&form=6&db=m Oxidative stress-mediated mouse liver lesions caused by Clonorchis sinensis infection. causal interaction,unassigned 4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28728977&form=6&db=m Synthesis and characterization of boron fenbufen and its F-18 labeled homolog for boron neutron capture therapy of COX-2 overexpressed cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,2
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29725387&form=6&db=m PF-2341066 combined with celecoxib promotes apoptosis and inhibits proliferation in human cholangiocarcinoma QBC939 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872269&form=6&db=m Synthesis and evaluation of ortho-[18F] fluorocelecoxib for COX-2 cholangiocarcinoma imaging. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30233800&form=6&db=m High promoter activity of cytokeratin-19 gene in cholangiocarcinoma. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30753687&form=6&db=m Effects of Aspirin and Non-Steroidal Anti-Inflammatory Drugs on the Risk of Cholangiocarcinoma: A Meta-Analysis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Cholangitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15017670&form=6&db=m Prostaglandin E receptors in bile ducts of hepatolithiasis patients and the pathobiological significance for cholangitis. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Cholangitis, Sclerosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584358&form=6&db=m Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Cholangitis, Sclerosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12143054&form=6&db=m ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Cholangitis, Sclerosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651971&form=6&db=m Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery. unassigned -
1.14.99.1 Cholangitis, Sclerosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23900502&form=6&db=m Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: ?mplications for cholangiocarcinogenesis. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Cholecystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2645856&form=6&db=m Evaluation of prostacyclin production by human gallbladder. unassigned -
1.14.99.1 Cholecystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2666254&form=6&db=m Arachidonic acid metabolites in hepatobiliary physiology and disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cholecystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3896701&form=6&db=m Effect of oral ibuprofen on formation of prostaglandins E and F by human gallbladder muscle and mucosa. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Cholecystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7268625&form=6&db=m Indomethacin intravenously--a new way for effective relief of biliary pain: a double-blind study in man. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cholecystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9841984&form=6&db=m Role of cyclooxygenase-2 for fluid secretion by the inflamed gallbladder mucosa. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cholecystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029518&form=6&db=m Cyclooxygenase expression in the gallbladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Cholecystitis, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105877&form=6&db=m Treatment of biliary colic and acute cholecystitis with prostaglandin synthetase inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Choledochal Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12508379&form=6&db=m Proliferative activity of bile from congenital choledochal cyst patients. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Choledochal Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20084600&form=6&db=m Cyclooxygenase-2 Overexpression is Associated with Clinical Outcome in Biliary Atresia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Choledochal Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26176076&form=6&db=m Carcinogenic Potential of Biliary Epithelium of Congenital Choledochal Cyst Model in Rats: A Special Reference to HDAC Expression. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=172982&form=6&db=m Effects of indomethacin on intestinal secretion, prostaglandin E and cyclic AMP: evidence against a role for prostaglandins in cholera toxin-induced secretion. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=187046&form=6&db=m Differential effects of prostaglandin synthetase inhibitors on prostaglandin E2 binding and on prostaglandin- or cholera toxin-induced cyclic AMP accumulation in the rabbit uterus. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615808&form=6&db=m Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8179336&form=6&db=m Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes. therapeutic application,unassigned 2,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692680&form=6&db=m PDGF-stimulated cyclic AMP formation in airway smooth muscle: assessment of the roles of MAP kinase, cytosolic phospholipase A2, and arachidonate metabolites. therapeutic application,unassigned 1,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10860826&form=6&db=m Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages. unassigned -
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11193597&form=6&db=m Mechanisms of cholera toxin-induced diarrhea. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356914&form=6&db=m Cholera toxin induces prostaglandin synthesis via post-transcriptional activation of cyclooxygenase-2 in the rat jejunum. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11379389&form=6&db=m Effects of indomethacin on Salmonella typhimurium- and cholera toxin-induced fluid accumulation in the porcine small intestine. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369781&form=6&db=m Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells. ongoing research,unassigned 2,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12906889&form=6&db=m Role of mast cells and pro-inflammatory mediators on the intestinal secretion induced by cholera toxin. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14573642&form=6&db=m Role of cyclooxygenase enzymes in a murine model of experimental cholera. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23147035&form=6&db=m Cholera toxin induces a shift from inactive to active cyclooxygenase 2 in alveolar macrophages activated by Mycobacterium bovis BCG. ongoing research,unassigned 2,0
1.14.99.1 Cholera http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27222028&form=6&db=m Pathophysiological mechanisms of diarrhea caused by the Vibrio cholerae O1 El Tor variant: an in vivo study in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Cholestasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462380&form=6&db=m Effect of selective cyclooxygenase-2 inhibitor meloxicam on liver fibrosis in rats with ligated common bile ducts. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Chondroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12324831&form=6&db=m Intracortical chondroblastoma mimicking intra-articular osteoid osteoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Chondroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13680221&form=6&db=m Expression of cyclooxygenase-2 in chondroblastoma: immunohistochemical analysis with special emphasis on local inflammatory reaction. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Chondroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19594492&form=6&db=m Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Chondroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218294&form=6&db=m Cyclooxygenase-2 expression in chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218294&form=6&db=m Cyclooxygenase-2 expression in chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16564923&form=6&db=m Cyclooxygenase-2 overexpression associated with a poor prognosis in chondrosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19594492&form=6&db=m Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004565&form=6&db=m COX-2 expression in chondrosarcoma: a role for celecoxib treatment? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20178602&form=6&db=m Cyclooxygenase-2 enhances alpha2beta1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660237&form=6&db=m Nitric oxide synthases, cyclooxygenase-2, nitrotyrosine, and angiogenesis in chondrosarcoma and their relation to prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21874258&form=6&db=m Cyclooxygenase-2 expression is not associated with clinical outcome in synovial sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23523690&form=6&db=m Endothelin-1 enhances cell migration through COX-2 up-regulation in human chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Chondrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24640098&form=6&db=m Expression of molecular markers in low-grade chondrosarcomas and cartilaginous tumors with uncertain differentiation. causal interaction,unassigned 4,0
1.14.99.1 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17709310&form=6&db=m Steroid hormone receptor and COX-2 expression in chordoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19594492&form=6&db=m Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Chordoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228328&form=6&db=m Expression of Ezrin, Mmp-9 and Cox-2 in 50 Chordoma Specimens: A Clinical and Immunohistochemical Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Chorioamnionitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14671209&form=6&db=m Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Chorioamnionitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981143&form=6&db=m Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on the cyclooxygenase-2 of human placenta in chorioamnionitis. ongoing research,unassigned 4,0
1.14.99.1 Chorioamnionitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15970823&form=6&db=m Placental expression of enzymes regulating prostaglandin synthesis and degradation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Chorioamnionitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16364008&form=6&db=m Evidence for interleukin-10-mediated inhibition of cyclo- oxygenase-2 expression and prostaglandin production in preterm human placenta. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Chorioamnionitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17017909&form=6&db=m In utero exposure to phthalates and fetal development. causal interaction,unassigned 3,0
1.14.99.1 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20881304&form=6&db=m Reduced Choroidal Neovascular Membrane Formation in Cyclooxygenase-2 Null Mice. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21928264&form=6&db=m Cyclooxygenase inhibitor improved an exudative lesion of choroidal neovascularization in age-related macular degeneration. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27626899&form=6&db=m Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization. therapeutic application,unassigned 1,0
1.14.99.1 Choroidal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27823554&form=6&db=m Topical Diclofenac-Loaded Liposomes Ameliorate Laser-Induced Choroidal Neovascularization in Mice and Non-Human Primates. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1890968&form=6&db=m A novel hypothesis concerning the mechanisms of activation, and of control, of periodontal bone loss. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11846190&form=6&db=m Gingival crevicular fluid matrix metalloproteinase-8 levels following adjunctive use of meloxicam and initial phase of periodontal therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,4
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12593597&form=6&db=m Effects of selective cyclooxygenase-2 inhibition on gingival tissue levels of prostaglandin E2 and prostaglandin F2alpha and clinical parameters of chronic periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12892443&form=6&db=m The overexpression of cyclo-oxygenase-2 in chronic periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18166099&form=6&db=m The effect of a selective cyclooxygenase-2 inhibitor (celecoxib) on chronic periodontitis. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236532&form=6&db=m Common single nucleotide polymorphisms in cyclooxygenase-2 and risk of severe chronic periodontitis in a Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20042743&form=6&db=m Alteration of PTGS2 promoter methylation in chronic periodontitis. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21047437&form=6&db=m Epigenetic change in E-Cardherin and COX-2 to predict chronic periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21481333&form=6&db=m Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22324469&form=6&db=m Cox-2 Expression in Gingival Biopsies From Periodontal Patients is Correlated With Connective Tissue Loss. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22819245&form=6&db=m Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23185695&form=6&db=m Cyclooxygenase 2 gene polymorphisms and chronic periodontitis in a North Indian population: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24267395&form=6&db=m COX-2 gene polymorphisms and risk of chronic periodontitis: a case-control study and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124319&form=6&db=m Elevated levels of cyclooxygenase 1 and 2 in human cyclosporine induced gingival overgrowth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743292&form=6&db=m Cyclooxygenase-2 and matrix metalloproteinase-9 expressions correlate with tissue inflammation degree in periodontal disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Chronic Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28523391&form=6&db=m The effect of low-level diode laser on COX-2 gene expression in chronic periodontitis patients. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12653769&form=6&db=m The selective cyclooxygenase-2 inhibitor rofecoxib may improve the treatment of chronic idiopathic urticaria. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12668898&form=6&db=m Prevention and treatment of reactions to NSAIDs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12743584&form=6&db=m A possible role for cyclooxygenase 2 inhibitors in the treatment of chronic urticaria. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14676074&form=6&db=m Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15967068&form=6&db=m Mechanism of chronic urticaria exacerbation by aspirin. therapeutic application,unassigned 3,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18842291&form=6&db=m Clinical course and urinary eicosanoids in patients with aspirin-induced urticaria followed up for 4 years. therapeutic application,unassigned 4,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519889&form=6&db=m Analgesics. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25562554&form=6&db=m Management of patients with nonaspirin-exacerbated respiratory disease aspirin hypersensitivity reactions. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29384107&form=6&db=m Restoration of aspirin tolerance following omalizumab treatment in a patient with chronic spontaneous urticaria. therapeutic application,unassigned 3,0
1.14.99.1 Chronic Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32467688&form=6&db=m The effect of levocetirizine and montelukast on clinical symptoms, serum level and skin expression of COX-1 and COX-2 enzymes in patients suffering from chronic autoimmune urticaria - a pilot study. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Cleft Palate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3885248&form=6&db=m Palatal development and the arachidonic acid cascade. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Cleft Palate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6389029&form=6&db=m Biochemical mechanism of glucocorticoid-and phenytoin-induced cleft palate. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Clonorchiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15086604&form=6&db=m Expression of cyclooxygenase-2 in cholangiocarcinoma: correlation with clinicopathological features and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14741133&form=6&db=m Expression of immune response genes in rainbow trout skin induced by Gyrodactylus derjavini infections. therapeutic application,unassigned 1,0
1.14.99.1 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22135046&form=6&db=m The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743193&form=6&db=m Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30139224&form=6&db=m The Association of PNPLA3, COX-2 and DHCR7 Polymorphisms with Advanced Liver Fibrosis in Patients with HCV Mono- Infection and HCV/HIV Co-Infection causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33307121&form=6&db=m The role of annexin A1 in Candida albicans and Candida auris infections in murine neutrophils. causal interaction,unassigned 1,0
1.14.99.1 Coinfection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33860122&form=6&db=m Establishment of a Cell Culture Model Permissive for Infection by Hepatitis B and C Viruses. causal interaction,unassigned 1,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1889968&form=6&db=m Diclofenac sodium and spasmolytic drugs in the treatment of ureteral colic: a comparative study. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2021808&form=6&db=m Eicosanoid synthesis in the isolated human renal pelvis, ureter and bladder. therapeutic application,unassigned 4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105877&form=6&db=m Treatment of biliary colic and acute cholecystitis with prostaglandin synthetase inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2265331&form=6&db=m Treatment of renal colic by prostaglandin synthetase inhibitors and avafortan (analgesic antispasmodic). ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2635871&form=6&db=m Indomethacin as prophylaxis against ureteral colic following extracorporeal shock wave lithotripsy. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2939715&form=6&db=m Use of diclofenac in analgesia. therapeutic application,unassigned 4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3890435&form=6&db=m Comparison of a narcotic (oxicone) and a non-narcotic anti-inflammatory analgesic (indoprofen) in the treatment of renal colic. therapeutic application,unassigned 4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3928014&form=6&db=m Prostaglandin synthetase inhibition of renal pelvic smooth muscle in the rabbit. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6357890&form=6&db=m Diclofenac sodium in ureteral colic: a double-blind comparison trial with placebo. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7714949&form=6&db=m Treatment of renal colic by desmopressin intranasal spray and diclofenac sodium. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7846111&form=6&db=m The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10647695&form=6&db=m Selective cyclooxygenase-2 inhibitors reduce ureteral contraction in vitro: a better alternative for renal colic? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11202384&form=6&db=m The role of cyclooxygenase inhibitors in repair of ischaemic-injured jejunal mucosa in the horse. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11221916&form=6&db=m Diclofenac and NS-398, a selective cyclooxygenase-2 inhibitor, decrease agonist-induced contractions of the pig isolated ureter. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16093996&form=6&db=m A double-blind, placebo controlled comparison of the morphine sparing effect of oral rofecoxib and diclofenac for acute renal colic. therapeutic application,unassigned 3,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17721281&form=6&db=m Real-time PCR analysis of RNA extracted from formalin-fixed and paraffin-embeded tissues: effects of the fixation on outcome reliability. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18324898&form=6&db=m Ketorolac effectively inhibits ureteral contractility in vitro. therapeutic application,unassigned 1,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20361960&form=6&db=m Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivo. ongoing research,unassigned 3,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20958135&form=6&db=m NS-398 (a Selective Cyclooxygenase-2 Inhibitor) Decreases Agonist-Induced Contraction of the Human Ureter via Calcium Channel Inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22234000&form=6&db=m Efficacy and safety of parecoxib in the treatment of acute renal colic: a randomized clinical trial. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Colic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305336&form=6&db=m Sparing the gut: COX-2 inhibitors herald a new era for treatment of horses with surgical colic. therapeutic application,unassigned 4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1330256&form=6&db=m Indomethacin worsens and a leukotriene biosynthesis inhibitor accelerates mucosal healing in rat colitis. ongoing research,unassigned 3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1553930&form=6&db=m Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. causal interaction,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1974733&form=6&db=m Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2177899&form=6&db=m The effect of essential fatty acid deficiency on eicosanoid production in the inflamed rat colonic mucosa. causal interaction,unassigned 4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2701650&form=6&db=m Interleukin-1 in the pathogenesis of and protection from inflammatory bowel disease. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3917261&form=6&db=m Metabolism of arachidonic acid in acetic acid colitis in rats. Similarity to human inflammatory bowel disease. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8425441&form=6&db=m Effects of cyclooxygenase and lipoxygenase inhibition on eicosanoids and healing of acetic acid colitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8498596&form=6&db=m On the suppression of food intake in experimental models of colitis in the rat. therapeutic application,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8598672&form=6&db=m The effect of trinitrobenzene sulfonic acid (TNB) on colonocyte arachidonic acid metabolism. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8903327&form=6&db=m Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679035&form=6&db=m Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10327390&form=6&db=m Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10527646&form=6&db=m Effect of dehydroleucodine in experimental colitis in rats and mice. therapeutic application,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683376&form=6&db=m Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10741939&form=6&db=m Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10898767&form=6&db=m Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11035215&form=6&db=m The effect of alpha-melanocyte stimulating hormone on colonic inflammation in the rat. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11137876&form=6&db=m Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11247889&form=6&db=m Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11424322&form=6&db=m Effects of Lactobacillus rhamnosus GG and Lactobacillus reuteri R2LC on acetic acid-induced colitis in rats. causal interaction,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11474431&form=6&db=m Role of inducible cyclooxygenase and prostaglandins in Clostridium difficile toxin A-induced secretion and inflammation in an animal model. ongoing research,unassigned 4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11698051&form=6&db=m Acute effects of the cys-leukotriene-1 receptor antagonist, montelukast, on experimental colitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11820457&form=6&db=m Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12021528&form=6&db=m Antisense inhibition of cyclooxygenase-2 causes a selective suppression of the Na+-H+ exchanger isoform 3 in rat kidney in experimental colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523593&form=6&db=m Cyclooxygenase-2 inhibition and experimental colitis: beneficial effects of phosphorothioated antisense oligonucleotide and meloxicam. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12673493&form=6&db=m Acetic acid-derived prostaglandin-dependent colonic adaptive cytoprotection is preserved in chronic colitis: role of cyclo-oxygenase. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730872&form=6&db=m A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. ongoing research,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12800246&form=6&db=m Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902846&form=6&db=m Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14501166&form=6&db=m [PPARgamma-gene therapy using an adenovirus vector for inflammatory bowel disease] causal interaction,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14518559&form=6&db=m Effect of nimesulide on acetic acid- and leukotriene-induced inflammatory bowel disease in rats. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14631309&form=6&db=m [Selective COX-2 inhibitor-associated colitis: two case reports] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,3
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633948&form=6&db=m Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020692&form=6&db=m Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15612245&form=6&db=m Effects and mechanism of the selective COX-2 inhibitor, celecoxib, on rat colitis induced by trinitrobenzene sulfonic acid. ongoing research,unassigned 3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659320&form=6&db=m The effects of selective cyclooxygenase-2 inhibitors, celecoxib and rofecoxib, on experimental colitis induced by acetic acid in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767259&form=6&db=m Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. causal interaction,unassigned 3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15825079&form=6&db=m Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15883736&form=6&db=m The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053267&form=6&db=m Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16251413&form=6&db=m Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474005&form=6&db=m Differential role of cyclooxygenase 1 and 2 isoforms in the modulation of colonic neuromuscular function in experimental inflammation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16500554&form=6&db=m Dietary fatty acids modulate chronic colitis, colitis-associated colon neoplasia and COX-2 expression in IL-10 knockout mice. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16518292&form=6&db=m [Acute colitis closely following the beginning of celecoxib treatment] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16585602&form=6&db=m Substance P Stimulates Cyclooxygenase-2 and Prostaglandin E2 Expression through JAK-STAT Activation in Human Colonic Epithelial Cells. ongoing research,unassigned 3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16614986&form=6&db=m Selective COX-2 Inhibition Reduces Leukocyte Sticking and Improves the Microcirculation in TNBS Colitis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16804969&form=6&db=m Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835710&form=6&db=m Mechanism underlying the reversal of contractility dysfunction in experimental colitis by cyclooxygenase-2 inhibition. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17143008&form=6&db=m Healing impairment effect of cyclooxygenase inhibitors on dextran sulfate sodium-induced colitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17268236&form=6&db=m Prostaglandins and epithelial response to injury. ongoing research,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17276891&form=6&db=m Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17656332&form=6&db=m Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model. causal interaction,unassigned 3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17716351&form=6&db=m Therapeutic effect of nimesulide on colorectal carcinogenesis in experimental murine ulcerative colitis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17943250&form=6&db=m Influence of simultaneous inhibition of cyclooxygenase-2 and inducible nitric oxide synthase in experimental colitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18054559&form=6&db=m Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. causal interaction,unassigned 4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058473&form=6&db=m Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18079364&form=6&db=m Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18256803&form=6&db=m Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18261323&form=6&db=m [Protective effect of epigallocatechin-3-gallate on inflammatory bowel disease: experiment with rat models of induced colitis] causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18458699&form=6&db=m [Mechanism of exacerbation of colonic damage in experimental colitis treated with celecoxib] causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18460552&form=6&db=m Protease-activated receptor-2 activation: a major actor in intestinal inflammation. causal interaction,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18502118&form=6&db=m Anti-inflammatory effects and changes in prostaglandin patterns induced by 7beta-hydroxy-epiandrosterone in rats with colitis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18536734&form=6&db=m Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice. ongoing research,unassigned 4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815359&form=6&db=m A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19101538&form=6&db=m Inhibition of both COX-1 and COX-2 and resulting decrease in the level of prostaglandins E2 is responsible for non-steroidal anti-inflammatory drug (NSAID)-dependent exacerbation of colitis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148357&form=6&db=m Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19359427&form=6&db=m A novel toll-like receptor 4 (TLR4) antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. therapeutic application,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19508397&form=6&db=m Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19617644&form=6&db=m Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19732774&form=6&db=m Regulation of Colonic Epithelial Repair in Mice by Toll-like Receptors and Hyaluronic Acid. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19744562&form=6&db=m Neurogenic contraction of mouse rectum via the cyclooxygenase pathway: Changes of PGE(2)-induced contraction with dextran sulfate sodium-induced colitis. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19941098&form=6&db=m Effect of COX-2 inhibitor after TNBS-induced colitis in Wistar rats. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20017653&form=6&db=m Inflammatory alterations in excluded colon in rats: a comparison with chemically induced colitis. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20361960&form=6&db=m Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivo. ongoing research,unassigned 3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20724486&form=6&db=m An ?-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-?B in rats with TNBS-induced colitis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21156970&form=6&db=m Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21733838&form=6&db=m Prevention of colitis-associated colorectal cancer with 8-hydroxydeoxyguanosine. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21783763&form=6&db=m Glycoprotein isolated from Ulmus davidiana Nakai modulates inflammatory related factors in mouse colonic tissues. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21874330&form=6&db=m Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model. causal interaction,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21887846&form=6&db=m Hyaluronic acid as a rescue therapy for trinitrobenzene sulfonic acid-induced colitis through Cox-2 and PGE2 in a Toll-like receptor 4-dependent way. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21893697&form=6&db=m Antibiotic treatment with ampicillin accelerates the healing of colonic damage impaired by aspirin and coxib in the experimental colitis. Importance of intestinal bacteria, colonic microcirculation and proinflammatory cytokines. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21925164&form=6&db=m Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in mice. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21958875&form=6&db=m Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21993246&form=6&db=m Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-? and inhibition of the Nf-?b inflammatory pathway. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22114936&form=6&db=m Oleuropein ameliorates acute colitis in mice. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22350949&form=6&db=m Nadroparin Sodium Activates Nrf2/HO-1 Pathway in Acetic Acid-Induced Colitis in Rats. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22381211&form=6&db=m Apple polyphenols extract (APE) improves colon damage in a rat model of colitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22426941&form=6&db=m Effect of COX-2 inhibitor lumiracoxib and the TNF-? antagonist etanercept on TNBS-induced colitis in Wistar rats. ongoing research,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22523290&form=6&db=m The role of nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors on experimental colitis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22538477&form=6&db=m Inhibitory effect of ?-sitosterol on TNBS-induced colitis in mice. ongoing research,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22679002&form=6&db=m MyD88 signaling promotes both mucosal homeostatic and fibrotic responses during Salmonella-induced colitis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22844504&form=6&db=m MC-12, an Annexin A1-Based Peptide, Is Effective in the Treatment of Experimental Colitis. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23034271&form=6&db=m Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1?, IL-6, TNF-?, COX-2, and apoptosisi. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23326291&form=6&db=m Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23373571&form=6&db=m The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23380599&form=6&db=m Prostaglandin ethanolamides attenuate damage in a human explant colitis model. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384476&form=6&db=m Mast cells and the cyclooxygenase pathway mediate colonic afferent nerve sensitization in a murine colitis model. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126114&form=6&db=m Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-?B signal transduction pathways in rats with ulcerative colitis. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24166708&form=6&db=m Protective effects of Pogostemon cablin Bentham water extract on inflammatory cytokine expression in TNBS-induced colitis in rats. diagnostic usage,unassigned 3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24269623&form=6&db=m Protective effect of marine mangrove Rhizophora apiculata on acetic acid induced experimental colitis by regulating anti-oxidant enzymes, inflammatory mediators and nuclear factor-kappa B subunits. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24306512&form=6&db=m Fatty acid synthase inhibitor C75 ameliorates experimental colitis. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25107843&form=6&db=m The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25193776&form=6&db=m The anti-inflammatory effects of a high-frequency oligodeoxynucleotide from the genomic DNA of Lactobacillus casei. therapeutic application,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25243883&form=6&db=m Modulating effect of Biophytum sensitivum extract on rats with acetic acid-induced ulcerative colitis. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25254662&form=6&db=m Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25393372&form=6&db=m Cyclooxygenase-2 silencing for the treatment of colitis: a combined in vivo strategy based on RNA interference and engineered Escherichia coli. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25414650&form=6&db=m Repeated predictable stress causes resilience against colitis-induced behavioral changes in mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25460165&form=6&db=m Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26069953&form=6&db=m Combined Therapy with Rheum tanguticum Polysaccharide and Low-dose 5-ASA Ameliorates TNBS-Induced Colitis in Rats by Suppression of NF-?B. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26227635&form=6&db=m The GPR55 antagonist CID16020046 protects against intestinal inflammation. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251576&form=6&db=m Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26253686&form=6&db=m Dipotassium glycyrrhizate via HMGB1 or AMPK signaling suppresses oxidative stress during intestinal inflammation. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26377354&form=6&db=m Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis. causal interaction,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26878787&form=6&db=m Preventive and therapeutic effects of blueberry (Vaccinium corymbosum) extract against DSS-induced ulcerative colitis by regulation of antioxidant and inflammatory mediators. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26973525&form=6&db=m Dietary Geraniol by Oral or Enema Administration Strongly Reduces Dysbiosis and Systemic Inflammation in Dextran Sulfate Sodium-Treated Mice. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27012631&form=6&db=m Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145379&form=6&db=m Effects of Prunus mume Sieb. et Zucc extract and its biopolymer encapsulation on a mouse model of colitis. ongoing research,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27177092&form=6&db=m Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability. causal interaction,unassigned 3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27255176&form=6&db=m Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27394986&form=6&db=m Protective effect of gentiopicroside against dextran sodium sulfate induced colitis in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27435110&form=6&db=m Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-?B and PPAR-? signaling pathways. ongoing research,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27657482&form=6&db=m Protective effect of isoquercitrin against acute dextran sulfate sodium-induced rat colitis depends on the severity of tissue damage. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27822176&form=6&db=m Ferulic acid ameliorates TNBS-induced ulcerative colitis through modulation of cytokines, oxidative stress, iNOs, COX-2, and apoptosis in laboratory rats. ongoing research,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28383063&form=6&db=m Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-?B and STAT3 activation. therapeutic application,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28494341&form=6&db=m Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities. causal interaction,unassigned 4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28556814&form=6&db=m Combined Treatment with Hyaluronic Acid and Mesalamine Protects Rats from Inflammatory Bowel Disease Induced by Intracolonic Administration of Trinitrobenzenesulfonic Acid. therapeutic application,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28587089&form=6&db=m Prevent Effects of Lactobacillus Fermentum HY01 on Dextran Sulfate Sodium-Induced Colitis in Mice. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659027&form=6&db=m Eclipta prostrata Improves DSS-Induced Colitis through Regulation of Inflammatory Response in Intestinal Epithelial Cells. ongoing research,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28690172&form=6&db=m Managing colonic inflammation associated gut derangements by systematically optimised and targeted ginger extract-Lactobacillus acidophilus loaded pharmacobiotic alginate beads. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28695925&form=6&db=m Anti-inflammatory effects of an ethanol extract of Aster glehni via inhibition of NF-?B activation in mice with DSS-induced colitis. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751820&form=6&db=m Cynanchum wilfordii Polysaccharides Suppress Dextran Sulfate Sodium-Induced Acute Colitis in Mice and the Production of Inflammatory Mediators from Macrophages. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28992661&form=6&db=m The Anti-Inflammatory Potential of Mimosa caesalpiniifolia Following Experimental Colitis: Role of COX-2 and TNF-Alpha Expression. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29629345&form=6&db=m Comparative Effects of Curcumin and Tetrahydrocurcumin on Dextran Sulfate Sodium-induced Colitis and Inflammatory Signaling in Mice. causal interaction,unassigned 4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30137286&form=6&db=m Rectal Insulin Instillation Inhibits Inflammation and Tumor Development in Chemically Induced Colitis. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231491&form=6&db=m The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice. ongoing research,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30365937&form=6&db=m Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30386616&form=6&db=m Peptide Hp(2-20) accelerates healing of TNBS-induced colitis in the rat. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683827&form=6&db=m Host nuclear factor erythroid 2-related factor-2 defense system determines the outcome of dextran sulfate sodium-induced colitis in mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30848228&form=6&db=m Mesalazine activates adenosine monophosphate-activated protein kinase: Implication in the anti-inflammatory activity of this anti-colitic drug. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864851&form=6&db=m Chemopreventive Activity of Red Ginseng Oil in a Mouse Model of Azoxymethane/Dextran Sulfate Sodium-Induced Inflammation-Associated Colon Carcinogenesis. causal interaction,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30981879&form=6&db=m Effects of 17?-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice. ongoing research,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31018218&form=6&db=m Quercus ilex Extract Ameliorates Acute TNBS-Induced Colitis in Rats. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31105713&form=6&db=m Dipotassium Glycyrrhizate Improves Intestinal Mucosal Healing by Modulating Extracellular Matrix Remodeling Genes and Restoring Epithelial Barrier Functions. therapeutic application,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31115770&form=6&db=m Protective Effects of Tyrosol Against DSS-Induced Ulcerative Colitis in Rats. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31117199&form=6&db=m Effect of Forced Physical Activity on the Severity of Experimental Colitis in Normal Weight and Obese Mice. Involvement of Oxidative Stress and Proinflammatory Biomarkers. ongoing research,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31204754&form=6&db=m The profiling of bioactives in Akebia trifoliata pericarp and metabolites, bioavailability and in vivo anti-inflammatory activities in DSS-induced colitis mice. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31248980&form=6&db=m Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31770044&form=6&db=m Protective Effects of Polysaccharide Extracted from Portulacae oleracea L. on Colitis Induced by Dextran Sulfate Sodium. causal interaction,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31825424&form=6&db=m Microalgae aqueous extracts exert intestinal protective effects in Caco-2 cells and dextran sodium sulphate-induced mouse colitis. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31835924&form=6&db=m Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of I?B-?/NF-?B and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31923541&form=6&db=m Aqueous extract of Bruguiera gymnorrhiza leaves protects against dextran sulfate sodium induced ulcerative colitis in mice via suppressing NF-?B activation and modulating intestinal microbiota. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32009962&form=6&db=m Gaudichaudione H Inhibits Inflammatory Responses in Macrophages and Dextran Sodium Sulfate-Induced Colitis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32109191&form=6&db=m Fresh Saengshik Showed a Positive Effect on Mitigating Dextran Sulfate Sodium-Induced Experimental Colitis in Mice. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32239858&form=6&db=m [null]. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32344663&form=6&db=m Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32422882&form=6&db=m Effects of Vitamin D Supplementation on Inflammation, Colonic Cell Kinetics, and Microbiota in Colitis: A Review. causal interaction,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442901&form=6&db=m Local administration of 4-Thiouridine, a novel molecule with potent anti-inflammatory properties, protects against experimental colitis and arthritis. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32459518&form=6&db=m Pharmabiotic beads with improved encapsulation and gut survival for management of colonic inflammation associated gut derangements. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32581538&form=6&db=m Berberine-Loaded Nanostructured Lipid Carriers Enhance the Treatment of Ulcerative Colitis. causal interaction,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32617046&form=6&db=m Gastroprotective effects of the nonsaponin fraction of Korean Red Ginseng through cyclooxygenase-1 upregulation. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32771947&form=6&db=m Clostridium butyricum modulates gut microbiota and reduces colitis associated colon cancer in mice. causal interaction,unassigned 3,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32991312&form=6&db=m Participation of the intestinal microbiota in the mechanism of beneficial effect of treatment with synbiotic Syngut on experimental colitis under stress conditions. diagnostic usage,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33092149&form=6&db=m Standardized Fraction of Turbinaria ornata Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice via Upregulation of FOXP3+ Regulatory T Cells. causal interaction,unassigned 2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33168409&form=6&db=m Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-?B signaling. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33256017&form=6&db=m AphaMax®, an Aphanizomenon Flos-Aquae Aqueous Extract, Exerts Intestinal Protective Effects in Experimental Colitis in Rats. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343354&form=6&db=m Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33352243&form=6&db=m Pharmacologycal activity of peperina (Minthostachys verticillata) on gastrointestinal tract. causal interaction,unassigned 1,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33359865&form=6&db=m Dilodendron bipinnatum Radlk. extract alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration, TNF-? and IL-1? concentrations, IL-17 and COX-2 expressions, supporting mucus production and promotes an antioxidant effect. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33633749&form=6&db=m 15-Deoxy-?12,14-Prostaglandin J2 Promotes Resolution of Experimentally Induced Colitis. unassigned -
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34355008&form=6&db=m High Red Meat Intake Exacerbates Dextran Sulfate-Induced Colitis by Altering Gut Microbiota in Mice. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34494061&form=6&db=m The preventive effect and underlying mechanism of Rhus chinensis Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colitis, Collagenous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19594490&form=6&db=m Cyclooxygenase-2 immunoreactivity in collagenous colitis. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Colitis, Ischemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32149087&form=6&db=m Polydeoxyribonucleotide Exerts Therapeutic Effect by Increasing VEGF and Inhibiting Inflammatory Cytokines in Ischemic Colitis Rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=40848&form=6&db=m Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine, codeine phosphate and prednisolone. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=101423&form=6&db=m Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2824300&form=6&db=m In vivo effects of orally administered prednisolone on prostaglandin and leucotriene production in ulcerative colitis. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2866075&form=6&db=m Modulation of human colonic arachidonic acid metabolism by sulfasalazine. causal interaction,unassigned 4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679035&form=6&db=m Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10213117&form=6&db=m Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10327390&form=6&db=m Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10648462&form=6&db=m Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980113&form=6&db=m The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11247889&form=6&db=m Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14664173&form=6&db=m [Synthesis of eicosanoids in the colonic mucosa in patients with ulcerative colitis] ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069531&form=6&db=m Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15232145&form=6&db=m Expression of cyclooxygenase-2 and nitric oxide synthase 2 in swine ulcerative colitis caused by Salmonella typhimurium. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16469681&form=6&db=m Safety of celecoxib in patients with ulcerative colitis in remission: a randomized, placebo-controlled, pilot study. therapeutic application,unassigned 4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17230539&form=6&db=m Colonic expression of leukotriene-pathway enzymes in inflammatory bowel diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429720&form=6&db=m Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. ongoing research,unassigned 4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653443&form=6&db=m Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17943250&form=6&db=m Influence of simultaneous inhibition of cyclooxygenase-2 and inducible nitric oxide synthase in experimental colitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18705313&form=6&db=m Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population. ongoing research,unassigned 3,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19594490&form=6&db=m Cyclooxygenase-2 immunoreactivity in collagenous colitis. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19617644&form=6&db=m Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19711064&form=6&db=m Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality? ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20198312&form=6&db=m Oral treatment with HE3286 ameliorates disease in rodent models of rheumatoid arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21451211&form=6&db=m Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis. therapeutic application,unassigned 1,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21925164&form=6&db=m Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in mice. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22039321&form=6&db=m Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23261717&form=6&db=m Ulcerative colitis-induced hepatic damage in mice: studies on inflammation, fibrosis, oxidative DNA damage and GST-P expression. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23529322&form=6&db=m COX-2 and Ki-67 immunohistochemical markers in the assessment of long-standing ulcerative colitis associated dysplasia. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126114&form=6&db=m Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-?B signal transduction pathways in rats with ulcerative colitis. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24692797&form=6&db=m Role of selective cyclooxygenase-2 inhibitors in exacerbation of inflammatory bowel disease: A systematic review and meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25393372&form=6&db=m Cyclooxygenase-2 silencing for the treatment of colitis: a combined in vivo strategy based on RNA interference and engineered Escherichia coli. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27822176&form=6&db=m Ferulic acid ameliorates TNBS-induced ulcerative colitis through modulation of cytokines, oxidative stress, iNOs, COX-2, and apoptosis in laboratory rats. ongoing research,unassigned 2,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28260017&form=6&db=m D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways. ongoing research,unassigned 2,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28420140&form=6&db=m Oleuropein Decreases Cyclooxygenase-2 and Interleukin-17 Expression and Attenuates Inflammatory Damage in Colonic Samples from Ulcerative Colitis Patients. causal interaction,unassigned 2,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29620794&form=6&db=m Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30023227&form=6&db=m Immunohistochemical expression of proinflammatory enzyme COX-2 and p53 in ulcerative colitis and its associated dysplasia and colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32600331&form=6&db=m Analysis of the pharmacological mechanism of Banxia Xiexin decoction in treating depression and ulcerative colitis based on a biological network module. therapeutic application,unassigned 4,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865915&form=6&db=m Protective Effect of D-Carvone against Dextran Sulfate Sodium Induced Ulcerative Colitis in Balb/c Mice and LPS Induced RAW Cells via the Inhibition of COX-2 and TNF-?. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33359865&form=6&db=m Dilodendron bipinnatum Radlk. extract alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration, TNF-? and IL-1? concentrations, IL-17 and COX-2 expressions, supporting mucus production and promotes an antioxidant effect. unassigned -
1.14.99.1 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34361576&form=6&db=m Unravelling the Phytochemical Composition and the Pharmacological Properties of an Optimized Extract from the Fruit from Prunus mahaleb L.: From Traditional Liqueur Market to the Pharmacy Shelf. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18054559&form=6&db=m Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. causal interaction,unassigned 4,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19589728&form=6&db=m Inflammation and colorectal cancer. causal interaction,unassigned 3,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20061361&form=6&db=m Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22369306&form=6&db=m Inflammation in sporadic colorectal cancer. unassigned -
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401648&form=6&db=m Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23688423&form=6&db=m TNF-alpha and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR. causal interaction,unassigned 4,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24212947&form=6&db=m Toll-like receptor 4 signaling integrates intestinal inflammation with tumorigenesis: lessons from the murine model of colitis-associated cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24828543&form=6&db=m Dynamic microbe and molecule networks in a mouse model of colitis-associated colorectal cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25107843&form=6&db=m The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26004412&form=6&db=m Proteases and their receptors as mediators of inflammation-associated colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26262998&form=6&db=m Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31431500&form=6&db=m Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer. unassigned -
1.14.99.1 Colitis-Associated Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171525&form=6&db=m Angiogenin regulates PKD activation and COX-2 expression induced by TNF-? and bradykinin in the colonic myofibroblast. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colonic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=101423&form=6&db=m Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Colonic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251576&form=6&db=m Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7641194&form=6&db=m Expression of cyclooxygenase-1 and -2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7780968&form=6&db=m Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7812955&form=6&db=m Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8228569&form=6&db=m Altered eicosanoid levels in human colon cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8566864&form=6&db=m Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643486&form=6&db=m Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8653697&form=6&db=m Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9012840&form=6&db=m Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9096394&form=6&db=m Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9149043&form=6&db=m Aspirin, but not sodium salicylate, indomethacin, or nabumetone, reversibly suppresses 1,2-dimethylhydrazine-induced colonic aberrant crypt foci in rats. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151799&form=6&db=m Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9192825&form=6&db=m Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249646&form=6&db=m COX-1 and COX-2 tissue expression: implications and predictions. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9270014&form=6&db=m Dietary fat and colon cancer: modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9327228&form=6&db=m Experimental models of gene-environment interaction for cancer chemoprevention studies. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9344613&form=6&db=m Prostaglandin H synthase expression is variable in human colorectal adenocarcinoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9388681&form=6&db=m Fenretinide inhibits phorbol ester-induced cyclooxygenase-2 expression in human colon adenocarcinoma cells. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9443418&form=6&db=m Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458081&form=6&db=m Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9503473&form=6&db=m Why is cyclooxygenase-2 expressed in neuroendocrine cells of the human alimentary tract? ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9561441&form=6&db=m Mechanism of action of antiinflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589361&form=6&db=m Colon cancer chemoprevention: clinical development of aspirin as a chemopreventive agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9596581&form=6&db=m Aspirin-like molecules that covalently inactivate cyclooxygenase-2. therapeutic application,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9597150&form=6&db=m Cyclooxygenases 1 and 2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9630216&form=6&db=m Cyclooxygenase regulates angiogenesis induced by colon cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9703885&form=6&db=m Cyclooxygenase-2 expression in human adenocarcinoma cell line HT29 cl.19A. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9734399&form=6&db=m Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9752793&form=6&db=m Induction of apoptosis in colon cancer cells by nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9773924&form=6&db=m Roles of COX-1 and COX-2 in gastrointestinal pathophysiology. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9822550&form=6&db=m Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831328&form=6&db=m Anti-inflammatory drugs and their mechanism of action. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831333&form=6&db=m COX-2 and colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846504&form=6&db=m Expression of cyclooxygenase-2 protein in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886578&form=6&db=m Meloxicam inhibits the growth of colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9889540&form=6&db=m [Colon cancer and cyclooxygenase] diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10069452&form=6&db=m Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10193997&form=6&db=m Role of cyclooxygenase-1 and -2 in health and disease. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10228831&form=6&db=m Cyclooxygenase-2 expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390128&form=6&db=m The clinical potential of cyclooxygenase-2-specific inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10433483&form=6&db=m Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10444394&form=6&db=m Myofibroblasts. II. Intestinal subepithelial myofibroblasts. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449029&form=6&db=m Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10508481&form=6&db=m High expression of cyclooxygenase-2 in macrophages of human colonic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10604722&form=6&db=m Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630643&form=6&db=m The role of cyclooxygenases in inflammation, cancer, and development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10667579&form=6&db=m Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10690533&form=6&db=m Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710483&form=6&db=m COX-2 and colon cancer: Potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762021&form=6&db=m COX-2 and colon cancer: potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766173&form=6&db=m Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766797&form=6&db=m Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3'-untranslated region. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10783318&form=6&db=m Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10783320&form=6&db=m The COX-2 inhibitor nimesulide suppresses superoxide and 8-hydroxy-deoxyguanosine formation, and stimulates apoptosis in mucosa during early colonic inflammation in rats. therapeutic application,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10866999&form=6&db=m Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873095&form=6&db=m Cyclooxygenase-2 expression is up-regulated in transitional cell carcinoma and its preneoplastic lesions in the human urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874009&form=6&db=m Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10911914&form=6&db=m Translational studies on Cox-2 inhibitors in the prevention and treatment of colon cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10919635&form=6&db=m Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10920275&form=6&db=m Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10930401&form=6&db=m Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005842&form=6&db=m Intracellular unesterified arachidonic acid signals apoptosis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11023534&form=6&db=m Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11028754&form=6&db=m Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078056&form=6&db=m Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11085935&form=6&db=m Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11118042&form=6&db=m Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135226&form=6&db=m COX-2 is expressed in human pulmonary, colonic, and mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11140899&form=6&db=m Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11150521&form=6&db=m Potential role of group X secretory phospholipase A(2) in cyclooxygenase-2-dependent PGE(2) formation during colon tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156377&form=6&db=m 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159881&form=6&db=m Colonic luminal contents induce cyclooxygenase 2 transcription in human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11166911&form=6&db=m The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11205258&form=6&db=m Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11216473&form=6&db=m COX-2 and iNOS, good targets for chemoprevention of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245490&form=6&db=m Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11266376&form=6&db=m Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11275997&form=6&db=m Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309352&form=6&db=m Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311743&form=6&db=m Cyclooxygenase inhibitors--current status and future prospects. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11319881&form=6&db=m Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375891&form=6&db=m Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11407522&form=6&db=m Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11429049&form=6&db=m Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib. therapeutic application,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11515678&form=6&db=m Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11532858&form=6&db=m Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566484&form=6&db=m Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595687&form=6&db=m A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11606477&form=6&db=m COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687954&form=6&db=m A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11688844&form=6&db=m Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11705450&form=6&db=m Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11705852&form=6&db=m Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729471&form=6&db=m [COX-2 inhibitor and colon cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11731423&form=6&db=m Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11733561&form=6&db=m Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11737227&form=6&db=m Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11807164&form=6&db=m COX-2: a target for colon cancer prevention. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11825662&form=6&db=m Suppression of promoter-dependent transcriptional activity of inducible nitric oxide synthase by sodium butyrate in colon cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11880271&form=6&db=m Regulation of COX-2 expression in human intestinal myofibroblasts: mechanisms of IL-1-mediated induction. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11888937&form=6&db=m Cyclooxygenase-2 activity altered the cell-surface carbohydrate antigens on colon cancer cells and enhanced liver metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891209&form=6&db=m Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11894121&form=6&db=m Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11925862&form=6&db=m [Colon cancer and COX-2] diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11931531&form=6&db=m Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943943&form=6&db=m Cyclooxygenase-2 expression in early gastric cancer, intestinal metaplasia and Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966530&form=6&db=m Review article: COX-2, prostanoids and colon cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11969241&form=6&db=m The treatment of advanced colorectal cancer: where are we now and where do we go? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12024111&form=6&db=m Rationale and feasibility of chemoprovention of hepatocellular carcinoma by cyclooxygenase-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060668&form=6&db=m Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066226&form=6&db=m Synergistic interaction between highly specific cyclooxygenase-2 inhibitor, MF-tricyclic and lovastatin in murine colorectal cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075826&form=6&db=m Studies on the development of colon-targeted delivery systems for celecoxib in the prevention of colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086402&form=6&db=m Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124799&form=6&db=m Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12138405&form=6&db=m A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12195185&form=6&db=m Cyclooxygenase-2 inhibition augments the hepatic antitumor effect of oral Salmonella typhimurium in a model of mouse metastatic colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204482&form=6&db=m Pain management and beyond: evolving concepts and treatments involving cyclooxygenase inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12208739&form=6&db=m Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414664&form=6&db=m Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12417326&form=6&db=m Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12423325&form=6&db=m The effects of acetylsalicylic acid on proliferation, apoptosis, and invasion of cyclooxygenase-2 negative colon cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432249&form=6&db=m Selenomethionine inhibits growth and suppresses cyclooxygenase-2 (COX-2) protein expression in human colon cancer cell lines. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432918&form=6&db=m Cyclooxygenases and colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12433707&form=6&db=m Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12439336&form=6&db=m Colocalization of BAX with BID and VDAC-1 in nimesulide-induced apoptosis of human colon adenocarcinoma COLO 205 cells. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468543&form=6&db=m Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12472107&form=6&db=m Role of cyclooxygenase-2 in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12480928&form=6&db=m Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12512030&form=6&db=m Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12596060&form=6&db=m Mucinous colon carcinomas with microsatellite instability have a lower microvessel density and lower vascular endothelial growth factor expression. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12598658&form=6&db=m Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12604350&form=6&db=m Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2. causal interaction,unassigned 2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12615711&form=6&db=m Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626523&form=6&db=m Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12629931&form=6&db=m Cyclooxygenase-2: from arthritis treatment to new indications for the prevention and treatment of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12632065&form=6&db=m Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398, a selective COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12644813&form=6&db=m Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12680220&form=6&db=m The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12702972&form=6&db=m Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706854&form=6&db=m Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727790&form=6&db=m Nitric oxide induces cyclooxygenase expression and inhibits cell growth in colon cancer cell lines. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12757841&form=6&db=m Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12759338&form=6&db=m Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. causal interaction,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767075&form=6&db=m Increased toxicity and lack of efficacy of Rofecoxib in combination with chemotherapy for treatment of metastatic colorectal cancer: A phase II study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767532&form=6&db=m Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12774242&form=6&db=m Cyclo-oxygenase 2 inhibitors: emerging roles in the gut. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12778076&form=6&db=m Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824918&form=6&db=m Colon cancer cells with high invasive potential are susceptible to induction of apoptosis by a selective COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839936&form=6&db=m Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839952&form=6&db=m Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12847753&form=6&db=m The role of cyclooxygenase-2 in the pathogenesis of skin cancer. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12885872&form=6&db=m Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902858&form=6&db=m Rofecoxib (Vioxx), a specific cyclooxygenase-2 inhibitor, is chemopreventive in a mouse model of colon cancer. therapeutic application,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12925303&form=6&db=m Fish oil enhances targeted apoptosis during colon tumor initiation in part by downregulating Bcl-2. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958170&form=6&db=m Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12973428&form=6&db=m Nonsteroidal antiinflammatory agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12973431&form=6&db=m Clinical aspects of COX-2 inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500353&form=6&db=m Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14506281&form=6&db=m Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14521608&form=6&db=m Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14574941&form=6&db=m [Combined treatment with fluorinated pyrimidines and selective cyclooxygenase-2 inhibitors for liver metastasis of colon cancer] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14582702&form=6&db=m Expression of cyclooxygenase-2 in human hyperplastic gastric polyps. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14603531&form=6&db=m Reduction of intracellular pH inhibits constitutive expression of cyclooxygenase-2 in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633677&form=6&db=m Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14634277&form=6&db=m Cyclooxygenase-independent induction of p21WAF-1/cip1, apoptosis and differentiation by L-745,337, a selective PGH synthase-2 inhibitor, and salicylate in HT-29 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14643021&form=6&db=m Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654921&form=6&db=m Combined treatment with selective cyclooxygenase-2 inhibitor and fluorinated pyrimidines for liver metastasis of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14675489&form=6&db=m Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726667&form=6&db=m Effects of a selective cyclooxygenase-2 inhibitor on cancer cells in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14739610&form=6&db=m Cox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14742316&form=6&db=m Carcinogenic properties of proteins with pro-inflammatory activity from Streptococcus infantarius (formerly S.bovis). diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760389&form=6&db=m Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14985462&form=6&db=m Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991639&form=6&db=m Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15000150&form=6&db=m Role of cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014363&form=6&db=m Sequence-dependent effect of a cyclooxygenase-2 inhibitor on topoisomerase I inhibitor and 5-fluorouracil-induced cytotoxicity of colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15025797&form=6&db=m Cyclooxygenase-2 expression in right- and left-sided colon cancer: a rationale for optimization of cyclooxygenase-2 inhibitor therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15047127&form=6&db=m Levamisole modulates prostaglandin E2 production and cyclooxygenase II gene expression in human colonic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15063780&form=6&db=m Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069531&form=6&db=m Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087416&form=6&db=m Correspondence re: M. V. Swamy et al., Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. Cancer Res 2003;63:5239-42. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15144595&form=6&db=m [Effects of selective cyclooxygenase-2 inhibitor NS-398 on 5-fluorouracil chemotherapy and progression of colon cells: an experimental study] causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150618&form=6&db=m Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161935&form=6&db=m The modulating role of nuclear factor-kappaB in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. causal interaction,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15163551&form=6&db=m NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property? therapeutic application,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172114&form=6&db=m Antiproliferative crude soy saponin extract modulates the expression of IkappaBalpha, protein kinase C, and cyclooxygenase-2 in human colon cancer cells. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15199544&form=6&db=m Studies with the azoxymethane-rat preclinical model for assessing colon tumor development and chemoprevention. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15225597&form=6&db=m Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240129&form=6&db=m NSAIDs activate PTEN and other phosphatases in human colon cancer cells: novel mechanism for chemopreventive action of NSAIDs. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240520&form=6&db=m A cox-2 promoter-based replication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15255176&form=6&db=m Colon cancer: genomics and apoptotic events. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15274299&form=6&db=m PHGPx overexpression induces an increase in COX-2 activity in colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15297372&form=6&db=m Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298620&form=6&db=m Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15308583&form=6&db=m Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15325613&form=6&db=m NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332534&form=6&db=m [COX and study of cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355919&form=6&db=m Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15359292&form=6&db=m Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362039&form=6&db=m Ursodeoxycholate/Sulindac combination treatment effectively prevents intestinal adenomas in a mouse model of polyposis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15517878&form=6&db=m Cyclooxygenase-2 gene induction causes CDDP resistance in colon cancer cell line, HCT-15. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15566646&form=6&db=m [CHL prevent colon neoplasms in mice and its selective inhibition on COX-2] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15570007&form=6&db=m Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574495&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15588671&form=6&db=m Antioxidant activities of extracts from five anti-viral medicinal plants. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623844&form=6&db=m beta-Carotene downregulates the steady-state and heregulin-alpha-induced COX-2 pathways in colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637091&form=6&db=m Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637743&form=6&db=m Effect of NS-398 on colon cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655349&form=6&db=m Selenomethionine regulates cyclooxygenase-2 (COX-2) expression through nuclear factor-kappa B (NF-kappaB) in colon cancer cells. causal interaction,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655524&form=6&db=m Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15657353&form=6&db=m Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683997&form=6&db=m [Effects of combined use of curcumin and catechin on cyclooxygenase-2 mRNA expression in dimethylhydrazine-induced rat colon carcinogenesis] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15688382&form=6&db=m Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells. ongoing research,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695237&form=6&db=m Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15705869&form=6&db=m A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15713675&form=6&db=m Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723653&form=6&db=m Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743541&form=6&db=m JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767339&form=6&db=m PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15788676&form=6&db=m Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15842147&form=6&db=m [Study on inhibitory effect of matrine on cyclooxygenase-2 expression in colon cancer HT-29 cell line] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878334&form=6&db=m Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15883203&form=6&db=m Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15892897&form=6&db=m Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15896711&form=6&db=m Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15907789&form=6&db=m Resistance of prostate cancer cell lines to COX-2 inhibitor treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15971119&form=6&db=m Induction of apoptosis by Panduratin A isolated from Kaempferia pandurata in human colon cancer HT-29 cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974945&form=6&db=m Mechanisms of colon cancer prevention with and beyond COX-2 inhibition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15989624&form=6&db=m Selective cyclooxygenase-2 inhibitors: pharmacology, clinical effects and therapeutic potential. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15993407&form=6&db=m Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16004971&form=6&db=m Combination of cyclooxygenase-2 inhibitors and oxaliplatin increases the growth inhibition and death in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16015035&form=6&db=m Autocrine vascular endothelial growth factor/vascular endothelial growth factor receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055866&form=6&db=m COX-2 expression during early lung squamous cell carcinoma oncogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16091009&form=6&db=m In vitro effects on polydextrose by colonic bacteria and caco-2 cell cyclooxygenase gene expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115753&form=6&db=m Intron 1 retaining cyclooxygenase 1 splice variant is induced by osmotic stress in human intestinal epithelial cells. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16119982&form=6&db=m Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127422&form=6&db=m Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127636&form=6&db=m COX-2 inhibitors--IBC conference. 12-13 April 1999, Coronado, CA, USA. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136999&form=6&db=m [Effect of indomethacin on human colorectal cancer cells HCT116 and SW480] causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140976&form=6&db=m Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166323&form=6&db=m Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166455&form=6&db=m Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16177193&form=6&db=m Human fecal water inhibits COX-2 in colonic HT-29 cells: role of phenolic compounds. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16203768&form=6&db=m The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213893&form=6&db=m Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16215757&form=6&db=m PPAR-gamma is expressed and NF-kB pathway is activated and correlates positively with COX-2 expression in stromal myofibroblasts surrounding colon adenocarcinomas. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16216410&form=6&db=m Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16237757&form=6&db=m Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16276519&form=6&db=m Gamma-herpesvirus neoplasia: a growing role for COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16293724&form=6&db=m Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16319132&form=6&db=m Sphingosine kinase 1 is up-regulated in colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16321305&form=6&db=m [Molecular mechanism of cyclooxygenase-2 inhibitor in inhibition of proliferation of colon cancer cells by modulating Stat5 signal transduction pathway] causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16340194&form=6&db=m Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16353145&form=6&db=m Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16371720&form=6&db=m [Characteristics of colon cancer diagnosed in patients taking aspirin or warfarin] causal interaction,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391811&form=6&db=m Cyclooxygenase-2 knockdown by RNA interference in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16395701&form=6&db=m Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16399234&form=6&db=m Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells. therapeutic application,unassigned 2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16416603&form=6&db=m EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16458424&form=6&db=m Cytoplasmic phospholipase A2 expression in human colon adenocarcinoma is correlated with cyclooxygenase-2 expression and contributes to prostaglandin E2 production. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489533&form=6&db=m COX-2 Polymorphism, Use of Nonsteroidal Anti-Inflammatory Drugs, and Risk of Colon Cancer in African Americans (United States). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505112&form=6&db=m Restriction of adenoviral replication to the transcriptional intersection of two different promoters for colorectal and pancreatic cancer treatment. ongoing research,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16506021&form=6&db=m NF-kappaB/PPAR gamma and/or AP-1/PPAR gamma 'on/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16527254&form=6&db=m Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552572&form=6&db=m Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619535&form=6&db=m Curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa B /p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622456&form=6&db=m RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16682957&form=6&db=m Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16688727&form=6&db=m Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699180&form=6&db=m The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16773432&form=6&db=m Depressed-type early invasive colon cancer in a patient treated with cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797120&form=6&db=m Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16799479&form=6&db=m Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835340&form=6&db=m Celecoxib treatment alters the gene expression profile of normal colonic mucosa. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835502&form=6&db=m Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16841079&form=6&db=m The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16909108&form=6&db=m Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16909598&form=6&db=m [Effects of selective and non-selective cyclooxygenase-2 inhibitor on the growth of colon cancer cells] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16972245&form=6&db=m alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984374&form=6&db=m Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016440&form=6&db=m STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma; a common pathway of IFNgamma-mediated gene repression but not gene activation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17018629&form=6&db=m Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17038629&form=6&db=m Azoxymethane protects intestinal stem cells and reduces crypt epithelial mitosis through a COX-1-dependent mechanism. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047069&form=6&db=m Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17054584&form=6&db=m Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17072976&form=6&db=m Identification of specific genes and pathways involved in NSAIDs-induced apoptosis of human colon cancer cells. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17094434&form=6&db=m A celecoxib derivative potently inhibits proliferation of colon adenocarcinoma cells by induction of apoptosis. therapeutic application,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17121918&form=6&db=m Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17128412&form=6&db=m Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145847&form=6&db=m Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145853&form=6&db=m Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17147415&form=6&db=m Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17164142&form=6&db=m The role of cyclooxygenase-2 and prostaglandins in colon cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178380&form=6&db=m Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17183061&form=6&db=m Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17189670&form=6&db=m Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17277882&form=6&db=m Triptolide inhibits cyclooxygenase-2 and inducible nitric oxide synthase expression in human colon cancer and leukemia cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17278192&form=6&db=m Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17300864&form=6&db=m Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17406816&form=6&db=m Cyclo-oxygenase-independent inhibition of apoptosis and stimulation of proliferation by leptin in human colon cancer cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17604853&form=6&db=m An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612052&form=6&db=m Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17673467&form=6&db=m Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17711445&form=6&db=m Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17876541&form=6&db=m Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17877615&form=6&db=m Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17899765&form=6&db=m [Induction of NAG-1 gene expression in colon cancer cells by non-steroidal anti-inflammatory drugs] diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934920&form=6&db=m Chemopreventive effects of nonsteroidal anti-inflammatory drugs in the membrane lipid composition and fluidity parameters of the 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. therapeutic application,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17936723&form=6&db=m Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian cancer and colon cancer is independent of COX-2 expression levels. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17936921&form=6&db=m The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032824&form=6&db=m EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18033773&form=6&db=m Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18062235&form=6&db=m Chemopreventive effect of chitosan oligosaccharide against colon carcinogenesis. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18084316&form=6&db=m Celecoxib modulates adhesion of HT29 colon cancer cells to vascular endothelial cells by inhibiting ICAM-1 and VCAM-1 expression. ongoing research,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18084318&form=6&db=m Celecoxib decreases expression of the adhesion molecules ICAM-1 and VCAM-1 in a colon cancer cell line (HT29). ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097606&form=6&db=m Transcriptional regulation of the COX-2 expression by nitric oxide in colon cancer cell lines. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18203712&form=6&db=m Two distinct pathways for cyclooxygenase-2 protein degradation. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220742&form=6&db=m n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18222973&form=6&db=m DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281498&form=6&db=m Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18287774&form=6&db=m Comparison of protein expression by isotope-coded affinity tag labeling. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18310926&form=6&db=m The flavouring phytochemical 2-pentanone reduces prostaglandin production and COX-2 expression in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18320325&form=6&db=m The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18326857&form=6&db=m Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18339853&form=6&db=m Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18360718&form=6&db=m Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381589&form=6&db=m Resveratrol directly targets COX-2 to inhibit carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18427544&form=6&db=m Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18444174&form=6&db=m Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18479189&form=6&db=m GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. ongoing research,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18547544&form=6&db=m The anti-proliferative potency of celecoxib is not a class effect of coxibs. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18587421&form=6&db=m Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18593902&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18636671&form=6&db=m Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18648368&form=6&db=m Prostaglandin E2 stimulates Fas ligand expression via the EP1 receptor in colon cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18661347&form=6&db=m Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer. ongoing research,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18702823&form=6&db=m Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18936204&form=6&db=m Rosmarinic Acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18992738&form=6&db=m PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. therapeutic application,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017360&form=6&db=m Cyclooxygenase-2/Carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056647&form=6&db=m Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19088039&form=6&db=m Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19114773&form=6&db=m NSAIDs and the colon. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19133256&form=6&db=m MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19189639&form=6&db=m Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208339&form=6&db=m The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19244345&form=6&db=m Caveolin-1-mediated suppression of cyclooxygenase-2 via a {beta}-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258012&form=6&db=m Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19293639&form=6&db=m AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19347284&form=6&db=m Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPARdelta --> 14-3-3epsilon Pathway. therapeutic application,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19348044&form=6&db=m Can licorice lick colon cancer? causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19392653&form=6&db=m The cyclooxygenase-2 inhibitor etoricoxib is a potent chemopreventive agent of colon carcinogenesis in the rat model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19437564&form=6&db=m No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19445018&form=6&db=m Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19470241&form=6&db=m Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549529&form=6&db=m Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19636412&form=6&db=m CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672427&form=6&db=m Regression of follicular lymphoma with Devil's Claw: coincidence or causation? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680014&form=6&db=m Nonsteroidal antiinflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: a trip from peptic ulcer to colon cancer. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19682443&form=6&db=m Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19707506&form=6&db=m Cytoplasmic Expression of HuR is Related to Cyclooxygenase-2 Expression in Colon Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723101&form=6&db=m Green tea catechin controls apoptosis in colon cancer cells by attenuation of H2O2-stimulated COX-2 expression via the AMPK signaling pathway at low-dose H2O2. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723105&form=6&db=m Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723884&form=6&db=m Modulation of transcription by the peroxisome proliferator-activated receptor delta--binding RNA aptamer in colon cancer cells. diagnostic usage,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19755647&form=6&db=m Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19758985&form=6&db=m Two Pathways for Cyclooxygenase-2 Protein Degradation In Vivo. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19763245&form=6&db=m Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19770690&form=6&db=m The RNA-binding protein RBM3 is required for cell proliferation and protects against serum deprivation-induced cell death. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19787257&form=6&db=m Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19790197&form=6&db=m CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19794924&form=6&db=m Cyclooxygenase 2 modulates killing of cytotoxic T lymphocytes by colon cancer cells. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956499&form=6&db=m Co-Expression of Cox-2, C-Met and beta-catenin in Cells Forming Invasive front of Gallbladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19960513&form=6&db=m Caveolin-1 facilitates cyclooxygenase-2 protein degradation. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004562&form=6&db=m Hypertonic environment elicits cyclooxygenase-2-driven prostaglandin E2 generation by colon cancer cells: role of cytosolic phospholipase A2-alpha and kinase signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20020969&form=6&db=m Chemopreventive effects of nonsteroidal anti-inflammatory drugs on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043083&form=6&db=m Receptor and enzyme expression for prostanoid metabolism in colorectal cancer related to tumor tissue PGE2. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20046424&form=6&db=m Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20049376&form=6&db=m Chemopreventive response of diclofenac, a non-steroidal anti-inflammatory drug in experimental carcinogenesis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20061361&form=6&db=m Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200425&form=6&db=m PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20204254&form=6&db=m Effect of etoricoxib, a cyclooxygenase-2 selective inhibitor on aberrant crypt formation and apoptosis in 1,2 dimethyl hydrazine induced colon carcinogenesis in rat model. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20224909&form=6&db=m Inhibition of TNFalpha-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-kappaB- and MAPK-dependent mechanisms. therapeutic application,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332435&form=6&db=m Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346115&form=6&db=m Germinated brown rice (GBR) reduces the incidence of aberrant crypt foci with the involvement of beta-catenin and COX-2 in azoxymethane-induced colon cancer in rats. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20372792&form=6&db=m Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells. therapeutic application,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20396589&form=6&db=m Quercetin Suppresses Early Colon Carcinogenesis Partly through Inhibition of Inflammatory Mediators. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446020&form=6&db=m 17beta-Estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20484034&form=6&db=m Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20496179&form=6&db=m Celecoxib increases retinoid sensitivity in human colon cancer cell lines. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20511675&form=6&db=m Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20553228&form=6&db=m Nutritional targeting of cyclooxygenase-2 for colon cancer prevention. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20617408&form=6&db=m PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20625420&form=6&db=m RNAi-based strategies for cyclooxygenase-2 inhibition in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20654727&form=6&db=m Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20669245&form=6&db=m Effects of the black tea polyphenol theaflavin-2 on apoptotic and inflammatory pathways in vitro and in vivo. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20682995&form=6&db=m Antiproliferative effect of a novel nitro-oxy derivative of celecoxib in human colon cancer cells: role of COX-2 and nitric oxide. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717114&form=6&db=m Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20737317&form=6&db=m [Effect of COX-2 inhibitor on the expression of BCL-3 and cyclin D1 in human colon cancer cell line SW480] ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21058188&form=6&db=m Avenanthramides inhibit proliferation of human colon cancer cell lines in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21062968&form=6&db=m The effects of the stromal cell-derived cyclooxygenase-2 metabolite prostaglandin E2 on the proliferation of colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21163769&form=6&db=m [Application of non-steroidal anti-inflammatory drugs to enhance 5-fluorouracil efficacy in experimental systems]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21216846&form=6&db=m p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21246838&form=6&db=m [Preventive effects of berberine on experimental colon cancer and relationship with cyclooxygenase-2 expression]. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21262972&form=6&db=m Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation. causal interaction,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21351468&form=6&db=m [Celecoxib increased cellular ATRA sensitivity of human colon cancer cell lines through COX-2-independent mechanisms]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21401528&form=6&db=m Celecoxib reduces fluidity and decreases metastatic potential of colon cancer cell lines irrespective of COX-2 expression. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21438584&form=6&db=m Briarane Diterpenes Diminish COX-2 Expression in Human Colon Adenocarcinoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459756&form=6&db=m Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21559086&form=6&db=m Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21668942&form=6&db=m COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21679035&form=6&db=m Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21737640&form=6&db=m Correlation between COX-2 and APC expression in left versus right-sided human colon cancer. ongoing research,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763448&form=6&db=m Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21764859&form=6&db=m Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/beta-catenin/cyclin D1 signaling pathway in rats. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21822307&form=6&db=m A common single-nucleotide polymorphism in cyclooxygenase-2 disrupts microRNA-mediated regulation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21830386&form=6&db=m Cyclooxygenase-2 in Dukes B colon cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21830391&form=6&db=m Tristetraprolin downregulates the expression of both VEGF and COX-2 in human colon cancer. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21840302&form=6&db=m Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: A novel cyclooxygenase-inhibition-independent effect. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21853475&form=6&db=m UVB radiation-induced ?-catenin signaling is enhanced by COX-2 expression in keratinocytes. causal interaction,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21875326&form=6&db=m Light and Moderate Doses of Ethanol in Chemical Carcinogenesis of the Colon in Rats. diagnostic usage,unassigned 2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21882253&form=6&db=m Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21885812&form=6&db=m Chemoprevention of colon and small intestinal tumorigenesis in APC(Min/+) mice by licofelone, a novel dual 5-LOX/COX inhibitor: potential implications for human colon cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21909878&form=6&db=m Nitric Oxide (NO) and Cyclooxygenase-2 (COX-2) Cross-Talk in Co-Cultures of Tumor Spheroids with Normal Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21984018&form=6&db=m Synthesis, characterisation and biological evaluation of copper and silver complexes based on acetylsalicylic acid. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21989718&form=6&db=m Chemoprevention of DMH-induced rat colon carcinoma initiation by combination administration of piroxicam and C-phycocyanin. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002318&form=6&db=m A novel nitro-oxy substituted analogue of rofecoxib reduces human colon cancer cell growth. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22066110&form=6&db=m Up-regulation of cyclooxygenase-2-derived prostaglandin E(2) in colon cancer cells resistant to 5-fluorouracil. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22262921&form=6&db=m Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis. ongoing research,unassigned 2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22329897&form=6&db=m Indomethacin antagonizes EP(2) prostanoid receptor activation in LS174T human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22348284&form=6&db=m Preparation and in vitro evaluation of meloxicam-loaded PLGA nanoparticles on HT-29 human colon adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22376259&form=6&db=m Linkage Disequilibrium and Haplotype Analysis of COX-2 and Risk of Colorectal Adenoma Development. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22517768&form=6&db=m Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22544606&form=6&db=m ?-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22607196&form=6&db=m Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22678777&form=6&db=m PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22687485&form=6&db=m Anti-tumor activity of the novel hexahydrocannabinol analog LYR-8 in Human colorectal tumor xenograft is mediated through the inhibition of Akt and hypoxia-inducible factor-1? activation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22822342&form=6&db=m Cyclooxygenase 2 inhibitors and colon cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22866112&form=6&db=m A review of the anti-tumor effect of the combined administration of a cyclooxygenase-2 selective inhibitor and a non-specific immunostimulant protein-bound polysaccharide on an advanced colon cancer model using colon cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22885178&form=6&db=m Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22904679&form=6&db=m Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23008118&form=6&db=m Chemopreventive efficacy of green tea drinking against 1,2-dimethyl hydrazine-induced rat colon carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23010081&form=6&db=m Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR. therapeutic application,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23042097&form=6&db=m Hypoxia-inducible factor-2? is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23102197&form=6&db=m [Neoplastic effect of indomethacin in N-methyl-N-nitrosourea induced mammary carcinogenesis in female rats]. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23200247&form=6&db=m Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker. therapeutic application,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23285691&form=6&db=m Impact of celecoxib on soluble intercellular adhesion molecule-1 and soluble e-cadherin concentrations in human colon cancer cell line cultures exposed to phytic acid and TNF-alpha. therapeutic application,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23291777&form=6&db=m A novel NSAID derivative, phospho-ibuprofen, prevents AOM-induced colon cancer in rats. ongoing research,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23330808&form=6&db=m Melatonin potentiates the antiproliferative and pro-apoptotic effects of ursolic acid in colon cancer cells by modulating multiple signaling pathways. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23347845&form=6&db=m Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349335&form=6&db=m Positional isomers of aspirin are equally potent in inhibiting colon cancer cell growth: differences in mode of cyclooxygenase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23517721&form=6&db=m Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23629521&form=6&db=m Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23678395&form=6&db=m Chemoprevention of Colon Cancer by iNOS-Selective Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23737956&form=6&db=m Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23776069&form=6&db=m The -1195G allele increases the transcriptional activity of cyclooxygenase-2 gene (COX-2) in colon cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23803085&form=6&db=m Suppression of ?-catenin and Cyclooxygenase-2 Expression and Cell Proliferation in Azoxymethane-Induced Colonic Cancer in Rats by Rice Bran Phytic Acid (PA). causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23869759&form=6&db=m TNF?-activated stromal COX-2 signalling promotes proliferative and invasive potential of colon cancer epithelial cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23872169&form=6&db=m Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23905422&form=6&db=m [The role of TLR4 receptor in development of inflammation and carcinogenesis in ulcerative colitis and pharmacotherapy of this disorder]. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23909736&form=6&db=m Mechanisms involved in the antiproliferative and proapoptotic effects of unsaponifiable fraction of extra virgin olive oil on HT-29 cancer cells. causal interaction,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973650&form=6&db=m Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to G?i and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24220240&form=6&db=m 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24224098&form=6&db=m Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity of ? -Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity. therapeutic application,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24289544&form=6&db=m Dietary non-nutritive factors in targeting of regulatory molecules in colorectal cancer: an update. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24295787&form=6&db=m Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24376205&form=6&db=m Fluorophore-labeled cyclooxygenase-2 inhibitors for the imaging of cyclooxygenase-2 overexpression in cancer: synthesis and biological studies. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24687028&form=6&db=m Expression of HLA Class I Antigen, Aspirin Use, and Survival After a Diagnosis of Colon Cancer. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24688218&form=6&db=m Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc (Min/+) mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24815456&form=6&db=m Anticancer effect of COX-2 inhibitor DuP-697 alone and in combination with tyrosine kinase inhibitor (E7080) on colon cancer cell lines. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24861078&form=6&db=m Targeting angiogenic pathway for chemoprevention of experimental colon cancer using C-phycocyanin as cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24964992&form=6&db=m COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25013352&form=6&db=m Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25093007&form=6&db=m Primary and secondary prevention of colorectal cancer. therapeutic application,unassigned 2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25107843&form=6&db=m The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25168879&form=6&db=m Staurosporine synergistically potentiates the deoxycholate-mediated induction of COX-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25218028&form=6&db=m COX-2- and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25218594&form=6&db=m Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25432409&form=6&db=m Aspirin and COX-2 inhibitor use in patients with stage III colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25545478&form=6&db=m Intracellular colon cancer-associated Escherichia coli promote protumoral activities of human macrophages by inducing sustained COX-2 expression. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25643632&form=6&db=m HGF-activated colonic fibroblasts mediates carcinogenesis of colonic epithelial cancer cells via PKC-cMET-ERK1/2-COX-2 signaling. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25692008&form=6&db=m Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1? in HCA-7 human colon cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25759517&form=6&db=m Involvement of NADPH oxidases in suppression of cyclooxygenase-2 promoter-dependent transcriptional activities by sesamol. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25811420&form=6&db=m Cyclooxygenase as a target in chemoprevention by probiotics during 1,2-dimethylhydrazine induced colon carcinogenesis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25938544&form=6&db=m Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor. ongoing research,unassigned 2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26048994&form=6&db=m RE: Aspirin and COX-2 Inhibitor Use in Patients With Stage III Colon Cancer. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26069486&form=6&db=m Effect of liposomal celecoxib on proliferation of colon cancer cell and inhibition of DMBA-induced tumor in rat model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26100239&form=6&db=m Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26262998&form=6&db=m Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26269760&form=6&db=m Cyclooxygenase-2 knockdown using retinoic acid chalcone (RAC), a promising therapeutic strategy for colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26319435&form=6&db=m Positional isomerism markedly affects the growth inhibition of colon cancer cells by NOSH-aspirin: COX inhibition and modeling. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26347954&form=6&db=m Antiproliferative activity of New Zealand propolis and phenolic compounds vs human colorectal adenocarcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26352871&form=6&db=m Upregulation of C-C chemokine receptor type 7 expression by membrane-associated prostaglandin E synthase-1/prostaglandin E2 requires glycogen synthase kinase 3?-mediated signal transduction in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26470793&form=6&db=m Effect of Rumex Abyssinicus on preneoplastic lesions in dimethylhydrazine induced colon carcinogenesis in rats. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26491668&form=6&db=m Synergistic Inhibitory Effects of Cetuximab and Cisplatin on Human Colon Cancer Cell Growth via Inhibition of the ERK-Dependent EGF Receptor Signaling Pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498686&form=6&db=m Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26518053&form=6&db=m Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells. ongoing research,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680815&form=6&db=m Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680965&form=6&db=m Expression of Cyclooxygenase-2 and Tumor Microvessel Density in Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707712&form=6&db=m Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26957558&form=6&db=m MicroRNA MIR21 (miR-21) and PTGS2 expression in colorectal cancer and patient survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26997150&form=6&db=m The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27016075&form=6&db=m Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice. causal interaction,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27039721&form=6&db=m Expression Patterns of Cancer Stem Cell Markers During Specific Celecoxib Therapy in Multistep Rat Colon Carcinogenesis Bioassays. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27040803&form=6&db=m Resveratrol Treatment Inhibits Proliferation of and Induces Apoptosis in Human Colon Cancer Cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27093594&form=6&db=m Ethanolic Extract of Bark from Salix aegyptiaca Ameliorates 1,2-dimethylhydrazine-induced Colon Carcinogenesis in Mice by Reducing Oxidative Stress. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27101738&form=6&db=m Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-?-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27235711&form=6&db=m Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27339171&form=6&db=m A New Model to Study the Role of Arachidonic Acid in Colon Cancer Pathophysiology. causal interaction,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27354402&form=6&db=m Valdecoxib Recovers the Lipid Composition, Order and Dynamics in Colon Cancer Cell Lines Independent of COX-2 Expression: An ATR-FTIR Spectroscopy Study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27368132&form=6&db=m Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ?-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27383140&form=6&db=m Pyrimidine-based fluorescent COX-2 inhibitors: synthesis and biological evaluation. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27554763&form=6&db=m Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27566955&form=6&db=m Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27750207&form=6&db=m Free radical scavenging and COX-2 inhibition by simple colon metabolites of polyphenols: A theoretical approach. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27761963&form=6&db=m Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/?-catenin signaling pathway. ongoing research,unassigned 1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28275297&form=6&db=m Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28425852&form=6&db=m Discovery of Novel 2-Amino-5-(Substituted)-1,3,4-Thiadiazole Derivatives: New Utilities for Colon Cancer Treatment. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28448072&form=6&db=m Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454287&form=6&db=m Smad3 mutant mice develop colon cancer with overexpression of COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28479391&form=6&db=m Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583134&form=6&db=m Sphingosine kinase 1 expression enhances colon tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28584401&form=6&db=m Chemopreventive effects of a low-side-effect antibiotic drug, erythromycin, on mouse intestinal tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28587064&form=6&db=m Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28718684&form=6&db=m Role of GSK-3? in Regulation of Canonical Wnt/?-catenin Signaling and PI3-K/Akt Oncogenic Pathway in Colon Cancer. therapeutic application,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28787469&form=6&db=m Flavanols from Japanese quince (Chaenomeles japonica) fruit suppress expression of cyclooxygenase-2, metalloproteinase-9, and nuclear factor-kappaB in human colon cancer cells. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29049411&form=6&db=m XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29068698&form=6&db=m The Impact of Dietary Polyphenols on COX-2 Expression in Colorectal Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29201696&form=6&db=m Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29215713&form=6&db=m Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29899846&form=6&db=m Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30041241&form=6&db=m Sulforaphane, a Chemopreventive Compound, Inhibits Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Expression in Human HT-29 Colon Cancer Cells. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30183370&form=6&db=m Probiotics (Lactobacillus acidophilus and Lactobacillus rhamnosus GG) in Conjunction with Celecoxib (selective COX-2 inhibitor) Modulated DMH-Induced Early Experimental Colon Carcinogenesis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30567534&form=6&db=m Dihomo-?-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30570856&form=6&db=m Research on the inhibiting effect of tanshinone IIA on colon cancer cell growth via COX-2-Wnt/?-catenin signaling pathway. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30650553&form=6&db=m n-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30813251&form=6&db=m The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin-Resistance, Apoptosis, and Cox-2 Activity in Colon Cancer Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30826660&form=6&db=m Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30894570&form=6&db=m Inhibition of PGE2/EP4 receptor signaling enhances oxaliplatin efficacy in resistant colon cancer cells through modulation of oxidative stress. ongoing research,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30900666&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30959857&form=6&db=m Polysaccharide-Rich Fractions from Rosa rugosa Thunb.-Composition and Chemopreventive Potential. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980797&form=6&db=m Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31100474&form=6&db=m Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31120230&form=6&db=m Cadmium Induces Migration of Colon Cancer Cells: Roles of Reactive Oxygen Species, P38 and Cyclooxygenase-2. unassigned -
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31127990&form=6&db=m Effect of TGF-?1 on Apoptosis of Colon Cancer Cells Via the ERK Signaling Pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31509395&form=6&db=m Targeting Heterogeneous Tumors Using a Multifunctional Molecular Prodrug. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31844085&form=6&db=m C-phycocyanin: a natural product with radiosensitizing property for enhancement of colon cancer radiation therapy efficacy through inhibition of COX-2 expression. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31905343&form=6&db=m Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-?B to the COX-2 promoter. ongoing research,unassigned 3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32205045&form=6&db=m Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32333795&form=6&db=m Tumour-suppressive effect of oestrogen receptor ? in colorectal cancer patients, colon cancer cells, and a zebrafish model. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32410997&form=6&db=m Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32535107&form=6&db=m Characterization of cyclooxygenase-2 acetylation and prostanoid inhibition by aspirin in cellular systems. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33190014&form=6&db=m EP4 receptor as a novel promising therapeutic target in colon cancer. causal interaction,unassigned 4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343354&form=6&db=m Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33455946&form=6&db=m Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33821899&form=6&db=m Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) Randomized Clinical Trial. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34067294&form=6&db=m Circulating PTGS2, JAG1, GUCY2C and PGF mRNA in Peripheral Blood and Serum as Potential Biomarkers for Patients with Metastatic Colon Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34436652&form=6&db=m Diclofenac down-regulates COX-2 induced expression of CD44 and ICAM-1 in human HT29 colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34465013&form=6&db=m Upregulation of Prostaglandin E2 by Inducible Microsomal Prostaglandin E Synthase-1 in Colon Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34477527&form=6&db=m Protective Effect of Nerium Oleander Distillate and Tarantula Cubensis Alcoholic Extract on Cancer Biomarkers on Colon and Liver Tissues of Rats with Experimental Colon Cancer. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100030553&form=6&db=m Chemical composition of volatile oil from Citrus limettioides and their inhibition of colon cancer cell proliferation causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100079058&form=6&db=m Cranberry extract and quercetin modulate the expression of cyclooxygenase-2 (COX-2) and I?B? in human colon cancer cells diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3392848&form=6&db=m Indomethacin enhancement of lymphocyte responses to phytohemagglutinin in breast, stomach and colorectal cancer patients. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6601630&form=6&db=m Enhancement of T lymphocyte proliferative response to mitogens by indomethacin in breast and colorectal cancer patients. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7641194&form=6&db=m Expression of cyclooxygenase-1 and -2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7926468&form=6&db=m Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8566864&form=6&db=m Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613017&form=6&db=m Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8917629&form=6&db=m The role of cyclic AMP and oxygen intermediates in the inhibition of cellular immunity in cancer. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8960892&form=6&db=m Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9027660&form=6&db=m Cyclooxygenase, NSAIDs, and colorectal cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9096394&form=6&db=m Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9160111&form=6&db=m Colorectal cancer and nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9219313&form=6&db=m Mechanism of action of aspirin-like drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9263538&form=6&db=m Apoptosis induced by NS-398, a selective cyclooxygenase-2 inhibitor, in human colorectal cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9331087&form=6&db=m Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9394727&form=6&db=m A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458096&form=6&db=m Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9464487&form=6&db=m Cyclooxygenase-2-selective antagonists do not inhibit growth of colorectal carcinoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9546780&form=6&db=m COX-2 inhibitors for colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589361&form=6&db=m Colon cancer chemoprevention: clinical development of aspirin as a chemopreventive agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589912&form=6&db=m Chemopreventive effects of NSAIDs against colorectal cancer: regulation of apoptosis and mitosis by COX-1 and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9622066&form=6&db=m Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9627095&form=6&db=m Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9703885&form=6&db=m Cyclooxygenase-2 expression in human adenocarcinoma cell line HT29 cl.19A. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9705287&form=6&db=m Expression of 15-lipoxygenase by human colorectal carcinoma Caco-2 cells during apoptosis and cell differentiation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9739782&form=6&db=m Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9786316&form=6&db=m Promising new agents for treatment of patients with colorectal cancer. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9809985&form=6&db=m Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815550&form=6&db=m Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846504&form=6&db=m Expression of cyclooxygenase-2 protein in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9850081&form=6&db=m Reduced COX-2 protein in colorectal cancer with defective mismatch repair. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9858896&form=6&db=m Gene expression of cyclooxygenase-2, group II and cytosolic phospholipase A2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927047&form=6&db=m Expression of 15-lipoxygenase-1 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927187&form=6&db=m Regulation of cyclooxygenase-2 pathway by HER2 receptor. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027203&form=6&db=m Chemoprevention of colorectal cancer: dietary and pharmacologic approaches. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10069452&form=6&db=m Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188882&form=6&db=m Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10204802&form=6&db=m Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10213117&form=6&db=m Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10225537&form=6&db=m Specific COX-2 inhibitors in arthritis, oncology, and beyond: where is the science headed? causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364000&form=6&db=m Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398082&form=6&db=m Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419916&form=6&db=m Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10451445&form=6&db=m Induction of prostaglandin G/H synthase-2 in a canine model of spontaneous prostatic adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10471521&form=6&db=m Coordinate up-regulation of low-density lipoprotein receptor and cyclo-oxygenase-2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517428&form=6&db=m The relationship between cyclooxygenase-2 expression and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517910&form=6&db=m Differential expression of cyclooxygenase 2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10528897&form=6&db=m Chemoprevention of colorectal cancer through inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10545404&form=6&db=m Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567385&form=6&db=m Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism. causal interaction,unassigned 2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10604722&form=6&db=m Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10607736&form=6&db=m A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10612291&form=6&db=m Protein abundance alterations in matched sets of macroscopically normal colon mucosa and colorectal carcinoma. diagnostic usage,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10666384&form=6&db=m Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668484&form=6&db=m The role of COX-2 in intestinal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10704568&form=6&db=m Cox-2 expression in retinoblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710473&form=6&db=m Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10720771&form=6&db=m Nonsteroidal anti-inflammatory drugs, COX-2 and colorectal cancer. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10738133&form=6&db=m The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. ongoing research,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762011&form=6&db=m Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766162&form=6&db=m Cyclooxygenase-2, a colorectal cancer nonsteroidal anti-inflammatory drug target, is regulated by c-MYB. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10772828&form=6&db=m Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10783317&form=6&db=m Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10797271&form=6&db=m Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807405&form=6&db=m Review article: cyclooxygenase--a target for colon cancer prevention. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10841517&form=6&db=m Host cyclooxygenase-2 modulates carcinoma growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10843404&form=6&db=m Colorectal cancer chemoprevention: aspirin, other NSAID and COX-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10889181&form=6&db=m Prevention of colorectal cancer: tumor progression, chemoprevention, and COX-2 inhibition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10911914&form=6&db=m Translational studies on Cox-2 inhibitors in the prevention and treatment of colon cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10917546&form=6&db=m Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10917748&form=6&db=m Differential expression of cyclooxygenase 2 in human colorectal cancer. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10930401&form=6&db=m Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10945606&form=6&db=m Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11045053&form=6&db=m COX-2 inhibitors: a potential target for drug therapy in the management of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11051257&form=6&db=m Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062695&form=6&db=m Meloxicam inhibits the growth of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11087869&form=6&db=m Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11122816&form=6&db=m Cyclooxygenase-2 as a target for prevention of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156377&form=6&db=m 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159736&form=6&db=m Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11197048&form=6&db=m Non-steroidal anti-inflammatory drugs with different cyclooxygenase inhibitory profiles that prevent aberrant crypt foci formation but vary in acute gastrotoxicity in a rat model. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11206834&form=6&db=m Cyclooxygenase-2 expression in colorectal cancer liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11207507&form=6&db=m Review article: the prevention of colorectal cancer. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223821&form=6&db=m Expression of cyclooxygenase-2 in human gastric adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11228540&form=6&db=m Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11274170&form=6&db=m PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292836&form=6&db=m Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301836&form=6&db=m COX-2 inhibition in clinical cancer prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11302965&form=6&db=m Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11319881&form=6&db=m Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11328256&form=6&db=m Surveillance colonoscopy or chemoprevention with COX-2 inhibitors in average-risk post-polypectomy patients: a decision analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336575&form=6&db=m Celecoxib: a new option in the treatment of arthropathies and familial adenomatous polyposis. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342898&form=6&db=m Expression of cyclooxygenase-2 in patients with bladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11352853&form=6&db=m Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375891&form=6&db=m Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375952&form=6&db=m Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11396184&form=6&db=m Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11397667&form=6&db=m Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11407522&form=6&db=m Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11412039&form=6&db=m Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11429490&form=6&db=m Chemoprevention of colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11469677&form=6&db=m Cyclooxygenase-2: a novel target for cancer chemotherapy? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11503270&form=6&db=m [Clinical application of cyclooxygenase-2 inhibitors] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507063&form=6&db=m Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11515678&form=6&db=m Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11532880&form=6&db=m Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566043&form=6&db=m COX-2 inhibition and prevention of cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11577463&form=6&db=m [Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors] causal interaction,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687726&form=6&db=m Molecular basis of colorectal cancer - role of gastrin and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687954&form=6&db=m A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729113&form=6&db=m Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751448&form=6&db=m Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751489&form=6&db=m Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11764529&form=6&db=m Role of cyclooxygenase inhibitors for the prevention of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11769882&form=6&db=m An introduction to aspirin, NSAids, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis: part II. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786771&form=6&db=m Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11798601&form=6&db=m [Study on the effect of COX-2's selective inhibitor on human colorectal adenoma cells proliferation] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11839557&form=6&db=m Beta-catenin--a linchpin in colorectal carcinogenesis? causal interaction,unassigned 2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11845047&form=6&db=m [Rationale and prospects for the use of cyclooxygenase-2 (COX-2) inhibitors in colorectal cancer] therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857443&form=6&db=m Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11900248&form=6&db=m Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11948369&form=6&db=m New strategies for colorectal cancer prevention and treatment. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992399&form=6&db=m The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12003384&form=6&db=m Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12048163&form=6&db=m Expression of cytosolic and group X secretory phospholipase A(2) genes in human colorectal adenocarcinomas. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12049307&form=6&db=m Comparison of cyclo-oxygenase 2 expression in colorectal serrated adenomas to expression in tubular adenomas and hyperplastic polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12053285&form=6&db=m [Colorectal cancer and inhibition of cyclooxygenase-2] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066226&form=6&db=m Synergistic interaction between highly specific cyclooxygenase-2 inhibitor, MF-tricyclic and lovastatin in murine colorectal cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12074318&form=6&db=m Reducing the risk of colorectal cancer by intervening in the process of carcinogenesis: a status report. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12109806&form=6&db=m Preoperative chemoradiation for locally advanced rectal cancer: emerging treatment strategies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110643&form=6&db=m Cyclooxygenase-2 overexpression in colorectal cancer is associated with non-polypoid growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12127122&form=6&db=m Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12138405&form=6&db=m A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12189559&form=6&db=m COX-2 selective inhibition reverses the trophic properties of gastrin in colorectal cancer. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12208739&form=6&db=m Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12353842&form=6&db=m Progastrin and cyclooxygenase-2 in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12370807&form=6&db=m Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12405290&form=6&db=m Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414664&form=6&db=m Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421732&form=6&db=m Chemotherapy in colorectal cancer: new options and new challenges. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12423325&form=6&db=m The effects of acetylsalicylic acid on proliferation, apoptosis, and invasion of cyclooxygenase-2 negative colon cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12494894&form=6&db=m COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12520638&form=6&db=m Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523457&form=6&db=m Selective cyclooxygenase-2 inhibition: a target in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12560924&form=6&db=m Increased cyclooxygenase-2 expression in large flat colorectal tumors (laterally spreading tumors). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12566300&form=6&db=m Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12598658&form=6&db=m Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12600292&form=6&db=m [Relationship between carcinoembryonic antigen and cyclooxygenase 2 expression and colorectal cancer] diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622426&form=6&db=m Expression of cyclooxygenase-2 protein in colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12635357&form=6&db=m [Prophylaxis of colorectal cancer with non steroidal anti-inflammatory drugs- a new reality?] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12663496&form=6&db=m The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE(2) synthesis and cytotoxicity in human colorectal carcinoma cell lines. ongoing research,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664576&form=6&db=m Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664617&form=6&db=m Growth stimulation and epidermal growth factor receptor induction in cyclooxygenase-overexpressing human colon carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12680220&form=6&db=m The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12705063&form=6&db=m [Epidemiological studies for evaluating the role of cyclooxygenase in chemoprevention of malignant tumors] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12720297&form=6&db=m Variation in cyclooxygenase expression levels within the colorectum. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727794&form=6&db=m Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12734198&form=6&db=m Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12736102&form=6&db=m Molecular biomarkers of colorectal carcinogenesis and their role in surveillance and early intervention. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12743436&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in gastric hyperplastic polyp--association with polyp size. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12753878&form=6&db=m Potential effect of cyclooxygenase-2-specific inhibitors on the prevention of colorectal cancer: a cost-effectiveness analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767075&form=6&db=m Increased toxicity and lack of efficacy of Rofecoxib in combination with chemotherapy for treatment of metastatic colorectal cancer: A phase II study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12771929&form=6&db=m Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12783255&form=6&db=m Role of cyclooxygenase-2 in the angiogenesis of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795052&form=6&db=m Cyclooxygenase-2 and colorectal cancer. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12800231&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12802790&form=6&db=m Cyclooxygenase-2 inhibitors in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810453&form=6&db=m Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811209&form=6&db=m Poor prognosis of colorectal cancer in patients over 80 years old is associated with down-regulation of tumor suppressor genes. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12818365&form=6&db=m Positive and negative regulation of prostaglandin E2 biosynthesis in human colorectal carcinoma cells by cancer chemopreventive agents. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12837940&form=6&db=m Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839952&form=6&db=m Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12888902&form=6&db=m Apoptosis induction and enhancement of cytotoxicity of anticancer drugs by celecoxib, a selective cyclooxygenase-2 inhibitor, in human head and neck carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941199&form=6&db=m New targeted therapies in gastrointestinal cancers. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12945071&form=6&db=m Cyclo-oxygenase 2 inhibition in colorectal cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949718&form=6&db=m The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970891&form=6&db=m Role of COX-2 in carcinogenesis of colorectal cancer and its relationship with tumor biological characteristics and patients' prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500348&form=6&db=m Prostaglandin E2 stimulates the growth of colon cancer cells via induction of amphiregulin. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14506383&form=6&db=m Cyclo-oxygenase inhibition in colorectal adenomas and cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529404&form=6&db=m COX-2 and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552327&form=6&db=m COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14565811&form=6&db=m Use of NSAIDs for the chemoprevention of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14567460&form=6&db=m Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14585257&form=6&db=m Hereditary nonpolyposis colorectal cancer: preventive management. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587862&form=6&db=m COX-2 inhibitors for the prevention of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594936&form=6&db=m Chemoprevention of cancer--focusing on clinical trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14619964&form=6&db=m Arachidonic acid and colorectal carcinogenesis. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623549&form=6&db=m Cyclooxygenase-2 and chemoprevention of breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633654&form=6&db=m Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14640057&form=6&db=m [Cyclooxygenase(COX)-2-inhibition in the prevention and treatment of colorectal carcinoma] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654921&form=6&db=m Combined treatment with selective cyclooxygenase-2 inhibitor and fluorinated pyrimidines for liver metastasis of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14674624&form=6&db=m Regulation of cell growth by selective COX-2 inhibitors in oral carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14683503&form=6&db=m Cyclooxygenase inhibition and mechanisms of colorectal cancer prevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719128&form=6&db=m Study of cyclooxygenase-2 in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719154&form=6&db=m Overexpression of cyclooxygenase-2 correlates with chromosomal gain at the cyclooxygenase-2 locus and decreased patient survival in advanced colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719508&form=6&db=m Expression of beta-catenin, COX-2 and iNOS in colorectal cancer: relevance of COX-2 adn iNOS inhibitors for treatment in Malaysia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726653&form=6&db=m Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734479&form=6&db=m Celecoxib but not rofecoxib inhibits the growth of transformed cells in vitro. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760389&form=6&db=m Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14965325&form=6&db=m Cancer and cyclooxygenase-2 (COX-2) inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14976201&form=6&db=m Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15000150&form=6&db=m Role of cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15013430&form=6&db=m Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15025797&form=6&db=m Cyclooxygenase-2 expression in right- and left-sided colon cancer: a rationale for optimization of cyclooxygenase-2 inhibitor therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15047127&form=6&db=m Levamisole modulates prostaglandin E2 production and cyclooxygenase II gene expression in human colonic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15066917&form=6&db=m Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075004&form=6&db=m Expression of cyclooxygenase-1 and -2 and clinicopathologic features of colorectal cancer in northern Thailand. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15085079&form=6&db=m Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102673&form=6&db=m Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15112579&form=6&db=m Nuclear factor-kappa B regulates cyclooxygenase-2 expression and cell proliferation in human colorectal carcinoma tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15122305&form=6&db=m Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150618&form=6&db=m Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study. ongoing research,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15156159&form=6&db=m Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15163022&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in colorectal carcinoma assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15167166&form=6&db=m The relationship between cyclooxygenase-2 expression and characteristics of malignant transformation in human colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15173859&form=6&db=m Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15224350&form=6&db=m Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. causal interaction,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239336&form=6&db=m [Cyclooxygenase 2 inhibitors and colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15248379&form=6&db=m Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252926&form=6&db=m COX-2 inhibition and colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15285012&form=6&db=m COX-2 expression and tumor angiogenesis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15292928&form=6&db=m Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15300574&form=6&db=m Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15309515&form=6&db=m Prevention of colorectal cancer through the use of COX-2 selective inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15340847&form=6&db=m Cyclooxygenase-2 and its role in colorectal cancer development. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15353307&form=6&db=m Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358633&form=6&db=m n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15361286&form=6&db=m Relationship between COX-2 expression and clinicopathological features of colorectal cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15369633&form=6&db=m The specialty of colon and rectal surgery: its impact on patient care and role in academic medicine. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386343&form=6&db=m JTE-522, a selective COX-2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: a vascular cast model study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475936&form=6&db=m Cytoplasmic phospholipase A2 alpha overexpression in stromal cells is correlated with angiogenesis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501074&form=6&db=m COX-2 inhibition as a tool to treat and prevent colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15505432&form=6&db=m [Cyclooxygenase-2 expression according to size and location of gastric and colorectal tubular adenomas] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15525649&form=6&db=m Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539957&form=6&db=m WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth. causal interaction,unassigned 2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15566646&form=6&db=m [CHL prevent colon neoplasms in mice and its selective inhibition on COX-2] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585629&form=6&db=m Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15589595&form=6&db=m COX-2, c-KIT and HER-2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622585&form=6&db=m Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623626&form=6&db=m Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623639&form=6&db=m Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15626589&form=6&db=m Platelet activation in patients with colorectal cancer. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15628724&form=6&db=m Cyclooxygenase-2 expression in the hereditary mixed polyposis syndrome. unassigned -
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15668484&form=6&db=m Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. unassigned -
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15671526&form=6&db=m Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15694043&form=6&db=m [Expressions of cyclooxygenase-2 and cholecystokinin-B receptor mRNA in human colorectal cancer and their significances] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695237&form=6&db=m Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15720414&form=6&db=m Association between cyclooxygenase-2-expressing macrophages, ulceration and microvessel density in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15726508&form=6&db=m Cyclooxygenase-2 inhibition in colorectal cancer: boom or bust? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743541&form=6&db=m JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15746067&form=6&db=m Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753380&form=6&db=m Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754004&form=6&db=m Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754389&form=6&db=m Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15807932&form=6&db=m A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816542&form=6&db=m Growth inhibitory effect of celecoxib and rofecoxib on human colorectal carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823708&form=6&db=m Selenium supplementation may increase the efficacy of cetuximab in metastatic colorectal cancer patients. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15837998&form=6&db=m COX-2: a molecular target for colorectal cancer prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15841716&form=6&db=m Rofecoxib does not inhibit aberrant crypt foci formation but inhibits later steps in the development of experimental colorectal cancer: rofecoxib in experimental colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867236&form=6&db=m Intratumoral COX-2 gene expression is a predictive factor for colorectal cancer response to fluoropyrimidine-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899632&form=6&db=m [Cyclooxygenase 2 inhibitors and colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15908664&form=6&db=m Molecular determinants of cetuximab efficacy. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15921850&form=6&db=m Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15923435&form=6&db=m Concurrent EGFr and Cox-2 expression in colorectal cancer: proliferation impact and tumour spreading. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974944&form=6&db=m Low dose aspirin, COX-inhibition and chemoprevention of colorectal cancer. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15993407&form=6&db=m Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15993594&form=6&db=m In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000571&form=6&db=m Cyclooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16003752&form=6&db=m MF tricyclic and sulindac retard tumor formation in an animal model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16030091&form=6&db=m The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16032431&form=6&db=m Phosphatidylcholine-associated nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit DNA synthesis and the growth of colon cancer cells in vitro. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16042570&form=6&db=m Prospects in NSAID-derived chemoprevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083714&form=6&db=m Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16088234&form=6&db=m A phase II trial of irinotecan, 5-fluorouracil and leucovorin combined with celecoxib and glutamine as first-line therapy for advanced colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16099783&form=6&db=m The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16100520&form=6&db=m Potential use of COX-2-aromatase inhibitor combinations in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16110762&form=6&db=m Differential stromal and epithelial localization of cyclooxygenase-2 (COX-2) during colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136511&form=6&db=m COX-2 overexpression in canine tumors: potential therapeutic targets in oncology. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136748&form=6&db=m Cyclooxygenase-2 in sporadic colorectal polyps: immunohistochemical study and its importance in the early stages of colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16164044&form=6&db=m Prognostic importance of COX-2 expression in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16203768&form=6&db=m The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16205694&form=6&db=m Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16210875&form=6&db=m Cyclooxygenase-2 inhibition prevents colorectal cancer: from the bench to the bed side. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16237757&form=6&db=m Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247189&form=6&db=m Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16249351&form=6&db=m Combined therapy with weekly irinotecan, infusional 5-fluorouracil and the selective COX-2 inhibitor rofecoxib is a safe and effective second-line treatment in metastatic colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16254046&form=6&db=m Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16274925&form=6&db=m Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16293616&form=6&db=m Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16321305&form=6&db=m [Molecular mechanism of cyclooxygenase-2 inhibitor in inhibition of proliferation of colon cancer cells by modulating Stat5 signal transduction pathway] causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16324362&form=6&db=m [Correlation between Stat3 signal transduction pathway and expression of cyclooxygenase-2 in colorectal cancer cells] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16340194&form=6&db=m Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16343055&form=6&db=m Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357153&form=6&db=m Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16361154&form=6&db=m [Expression of COX-2 protein in colorectal carcinoma and the clinical implication] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391837&form=6&db=m Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407821&form=6&db=m Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16412030&form=6&db=m Chemoprevention of colorectal cancer with nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16413466&form=6&db=m Connecting COX-2 and Wnt in cancer. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16416603&form=6&db=m EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16420789&form=6&db=m [Cyclooxygenase-2 expression as a prognostic factor in sporadic colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16437990&form=6&db=m [Molecular epidemiologic analysis of the levels of metalloproteases and cyclooxygenase-2 in colorectal cancer] diagnostic usage,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16449227&form=6&db=m Endogenous lipid hydroperoxide-mediated DNA-adduct formation in min mice. ongoing research,unassigned 2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16458424&form=6&db=m Cytoplasmic phospholipase A2 expression in human colon adenocarcinoma is correlated with cyclooxygenase-2 expression and contributes to prostaglandin E2 production. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474989&form=6&db=m Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507396&form=6&db=m Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508969&form=6&db=m Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510588&form=6&db=m FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16540660&form=6&db=m Increased EP4 Receptor Expression in Colorectal Cancer Progression Promotes Cell Growth and Anchorage Independence. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16551850&form=6&db=m Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16615003&form=6&db=m Effects of cyclooxygenase-2 inhibition on serum and tumor gastrins and expression of apoptosis-related proteins in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622748&form=6&db=m Does a selective cyclooxygenase-2 inhibitor (tiracoxib) induce clinically sufficient suppression of adenomas in patients with familial adenomatous polyposis? A randomized double-blind placebo-controlled clinical trial. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685273&form=6&db=m Prostaglandin E(2) stimulates progression-related gene expression in early colorectal adenoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16688727&form=6&db=m Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699180&form=6&db=m The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16709411&form=6&db=m Upregulation of thromboxane synthase in human colorectal carcinoma and the cancer cell proliferation by thromboxane A2. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16752205&form=6&db=m Cyclooxygenase-2 expression correlates with membrane-type-1 matrix metalloproteinase expression in colorectal cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16755175&form=6&db=m Retrospective study of capecitabine and celecoxib in metastatic colorectal cancer: potential benefits and COX-2 as the common mediator in pain, toxicities and survival? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16766770&form=6&db=m Antiangiogenic activity of the selective cyclooxygenase 2 inhibitor rofecoxib in human colorectal cancer liver metastases. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16799479&form=6&db=m Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818642&form=6&db=m Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820091&form=6&db=m Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16821623&form=6&db=m Chemopreventive effects of Khaya senegalensis bark extract on human colorectal cancer. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16859832&form=6&db=m Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16909108&form=6&db=m Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16985019&form=6&db=m Proteomic profiling identifies cyclooxygenase-2-independent global proteomic changes by celecoxib in colorectal cancer cells. ongoing research,unassigned 2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996805&form=6&db=m Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016440&form=6&db=m STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma; a common pathway of IFNgamma-mediated gene repression but not gene activation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17031153&form=6&db=m Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17040897&form=6&db=m Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047069&form=6&db=m Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17054584&form=6&db=m Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062337&form=6&db=m [Association of abnormal cyclooxygenase-2 gene expression with colorectal carcinoma metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17066486&form=6&db=m Validation studies of the health improvement network (THIN) database for pharmacoepidemiology research. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17075120&form=6&db=m Prospective study of urinary prostaglandin E2 metabolite and colorectal cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17109196&form=6&db=m Immunohistochemical measurement of endothelial cell apoptosis and proliferation in formalin-fixed, paraffin-embedded human cancer tissue. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17121918&form=6&db=m Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145847&form=6&db=m Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151091&form=6&db=m Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178865&form=6&db=m RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17183061&form=6&db=m Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17209859&form=6&db=m Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17249380&form=6&db=m Cyclooxygenase-2 and tumor biology. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17301265&form=6&db=m Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17302187&form=6&db=m Cox-2 and cancer chemoprevention: picking up the pieces. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17325551&form=6&db=m Cyclooxygenase-2 expression in polyps from a patient with juvenile polyposis syndrome with mutant BMPR1A. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17339623&form=6&db=m Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17357536&form=6&db=m Tissue microarray-determined expression profiles of cyclooxygenase-2 in colorectal adenocarcinoma: association with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17374999&form=6&db=m Inflammatory mediators and nuclear receptor signaling in colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17378912&form=6&db=m Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403293&form=6&db=m [Evaluation of cyclooxygenase-2 in the prediction of liver metastasis of colorectal carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17415806&form=6&db=m Cyclooxygenase inhibitors in the chemoprevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429629&form=6&db=m Phase-II study of dose attenuated schedule of irinotecan, capecitabine, and celecoxib in advanced colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437271&form=6&db=m Prostaglandin F(2alpha) stimulates motility and invasion in colorectal tumor cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17450522&form=6&db=m Synergistic antitumor effects of celecoxib with 5-fluorouracil depend on IFN-gamma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17466901&form=6&db=m Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: two steps forward, one step back. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17488476&form=6&db=m Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493439&form=6&db=m [Cyclooxygenase 2 and colorectal cancer: therapeutic implications] causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17522398&form=6&db=m Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17555711&form=6&db=m Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594159&form=6&db=m Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17604853&form=6&db=m An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17608381&form=6&db=m Review: NSAIDs and COX-2 inhibitors may prevent colorectal cancer but increase gastrointestinal and cardiovascular harm. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17608853&form=6&db=m Involvement of cyclooxygenase-2 and vascular endothelial growth factor in vascularization and lymph node metastasis of colorectal cancers with submucosal invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640979&form=6&db=m HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17667525&form=6&db=m Rofecoxib has different effects on chemokine production in colorectal cancer cells and tumor immune splenocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17681160&form=6&db=m Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17710160&form=6&db=m Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17715417&form=6&db=m Aspirin, COX-2, and the risk of colorectal cancer. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17716351&form=6&db=m Therapeutic effect of nimesulide on colorectal carcinogenesis in experimental murine ulcerative colitis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17717859&form=6&db=m Aspirin, COX-2, and the risk of colorectal cancer. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17725981&form=6&db=m The effect of meloxicam, a selective COX-2 inhibitor, on the microvasculature of small metastatic liver tumors in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17762961&form=6&db=m 5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17767717&form=6&db=m The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17846040&form=6&db=m Correlations between cyclooxygenase-2 expression and angiogenic factors in primary tumors and liver metastases in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875695&form=6&db=m Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17876541&form=6&db=m Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17877615&form=6&db=m Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893232&form=6&db=m Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17923032&form=6&db=m [Selective cyclooxygenase-2 inhibitors for the prevention of colorectal adenomas: a meta-analysis] causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17929263&form=6&db=m Prognostic significance of cyclooxygenase-2 expression and nuclear p53 accumulation in patients with colorectal cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962941&form=6&db=m Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17981262&form=6&db=m Cyclooxygenase-2-dependent and -independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058808&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094611&form=6&db=m Increased expression of cytoplasmic HuR in familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18156308&form=6&db=m Chemoprevention of arylamine-induced colorectal aberrant crypts. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18228100&form=6&db=m Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230181&form=6&db=m Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18247029&form=6&db=m Celecoxib inhibits growth of tumors in a syngeneic rat liver metastases model for colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18256803&form=6&db=m Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18287774&form=6&db=m Comparison of protein expression by isotope-coded affinity tag labeling. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18301950&form=6&db=m Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18320325&form=6&db=m The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18350611&form=6&db=m Cyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18373616&form=6&db=m Diabetes, colorectal cancer and cyclooxygenase 2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438340&form=6&db=m Celecoxib inhibits tumor growth and angiogenesis in an orthotopic implantation tumor model of human colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18451151&form=6&db=m Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18507001&form=6&db=m Combination therapy of S-1 with selective cyclooxygenase-2 inhibitor for liver metastasis of colorectal carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18551182&form=6&db=m The Roles of Dietary PPARgamma Ligands for Metastasis in Colorectal Cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18636671&form=6&db=m Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18648741&form=6&db=m Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691269&form=6&db=m COX-2 expression is unexpectedly high in viable colorectal mucosal cells: is there life for chemoprophylaxis after VICTOR? therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18692059&form=6&db=m NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18708371&form=6&db=m Cyclooxygenase-2 inhibitors in colorectal cancer prevention: point. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18708372&form=6&db=m Cyclooxygenase-2 inhibitors in colorectal cancer prevention: counterpoint. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18720000&form=6&db=m The Simultaneous Expression of Peroxisome Proliferator-Activated Receptor Delta and Cyclooxygenase-2 May Enhance Angiogenesis and Tumor Venous Invasion in Tissues of Colorectal Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18778395&form=6&db=m COX-2 expression is unexpectedly high in viable colorectal mucosal cells: is there life for chemoprophylaxis after VICTOR? therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794809&form=6&db=m Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18844982&form=6&db=m Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis. unassigned -
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017360&form=6&db=m Cyclooxygenase-2/Carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19030198&form=6&db=m Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19035518&form=6&db=m Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19037088&form=6&db=m A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047118&form=6&db=m Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19075598&form=6&db=m Protective effect of NSAIDs on cancer and influence of COX-2 C(-765G) genotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19102009&form=6&db=m EGFR, HER-2 and COX-2 levels in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19119558&form=6&db=m Colorectal cancer: a summary of the evidence for screening and prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19121846&form=6&db=m Reduced beta-catenin and peroxisome proliferator-activated receptor-gamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132985&form=6&db=m Prognostic value of COX-2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19133256&form=6&db=m MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19136477&form=6&db=m The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147569&form=6&db=m Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148797&form=6&db=m NSAIDs and colorectal cancer prevention. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19219602&form=6&db=m Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236238&form=6&db=m Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268443&form=6&db=m Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19277703&form=6&db=m Comparison of cyclooxygenase-2 and CD44 mRNA expression in colorectal cancer and its relevance for prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287974&form=6&db=m Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336730&form=6&db=m Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19390125&form=6&db=m Expression of NF-kB and COX-2 in Young Versus Older Patients with Sporadic Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19390126&form=6&db=m Expression of NF-kB and COX-2 in Young Versus Older Patients with Sporadic Colorectal Cancer. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19410194&form=6&db=m Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19412426&form=6&db=m Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19451089&form=6&db=m Label-free global serum proteomic profiling reveals novel celecoxib-modulated proteins in familial adenomatous polyposis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19497798&form=6&db=m Heterogeneous expression of cyclooxygenase-2 and inducible nitric oxide synthase within colorectal tumors: Correlation with tumor angiogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19505922&form=6&db=m Fecal cyclooxygenase 2 plus matrix metalloproteinase 7 mRNA assays as a marker for colorectal cancer screening. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19513071&form=6&db=m Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549529&form=6&db=m Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19558693&form=6&db=m Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19571664&form=6&db=m Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19579928&form=6&db=m Correlation of cyclooxygenase 2 expression and inflammatory cells infiltration in colorectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19597346&form=6&db=m New perspectives on APC control of cell fate and proliferation in colorectal cancer. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19623659&form=6&db=m Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. ongoing research,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638428&form=6&db=m HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638987&form=6&db=m Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671325&form=6&db=m [Expression of cyclooxygenase-2 and relationship with mismatch repaire gene and microsatellite instability in hereditary non-polyposis colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671906&form=6&db=m Aspirin use and survival after diagnosis of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19707365&form=6&db=m Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19707506&form=6&db=m Cytoplasmic Expression of HuR is Related to Cyclooxygenase-2 Expression in Colon Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723105&form=6&db=m Effects of cotreatment of 12-O-tetradecanoylphorbol-13-acetate and H2O2 on apoptotic regulation via AMP-activated protein kinase-cyclooxygenase-2 signals. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19752603&form=6&db=m 15-lipoxygenase-1 in colorectal cancer: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19777615&form=6&db=m COX-2 polymorphisms -765G-->C and -1195A-->G and colorectal cancer risk. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19787257&form=6&db=m Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19789368&form=6&db=m Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19807353&form=6&db=m Potential cost-effectiveness of colorectal cancer chemoprevention with nonsteroidal anti-inflammatory drugs. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19830428&form=6&db=m Enhanced 5-fluorouracil cytotoxicity in high cyclooxygenase-2 expressing colorectal cancer cells and xenografts induced by non-steroidal anti-inflammatory drugs via downregulation of dihydropyrimidine dehydrogenase. therapeutic application,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895739&form=6&db=m [Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19930591&form=6&db=m Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19946329&form=6&db=m The role of COX-2 in intestinal inflammation and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026301&form=6&db=m Cell adhesion property affected by cyclooxygenase and lipoxygenase: Opto-electric approach. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20075740&form=6&db=m COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20081809&form=6&db=m CD133 expression predicts for non-response to chemotherapy in colorectal cancer. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20087348&form=6&db=m Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096072&form=6&db=m Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20144265&form=6&db=m Localization of cyclo-oxygenase-2 in human recurrent colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145612&form=6&db=m Factors that contribute to faecal cyclooxygenase-2 mRNA expression in subjects with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20221637&form=6&db=m Peroxisome-proliferator-activated receptors gamma and beta/delta mediate vascular endothelial growth factor production in colorectal tumor cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20348947&form=6&db=m The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20397022&form=6&db=m Additive inhibition of colorectal cancer cell lines by aspirin and bortezomib. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20507599&form=6&db=m Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20514410&form=6&db=m The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20514536&form=6&db=m The role of NF-?B and PPAR? in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20535630&form=6&db=m Eudragit S-100 entrapped chitosan microspheres of valdecoxib for colon cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20548327&form=6&db=m Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors. therapeutic application,unassigned 2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20553228&form=6&db=m Nutritional targeting of cyclooxygenase-2 for colon cancer prevention. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20571967&form=6&db=m Hypermethylation of RAR?2 correlates with high COX-2 expression and poor prognosis in patients with colorectal carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20577575&form=6&db=m Posttranscriptional Regulation of Cyclooxygenase 2 Expression in Colorectal Cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20625420&form=6&db=m RNAi-based strategies for cyclooxygenase-2 inhibition in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20633535&form=6&db=m Regular exercise reduces colon tumorigenesis associated with suppression of iNOS. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635443&form=6&db=m Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651346&form=6&db=m COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20697066&form=6&db=m Role of vitamin and mineral supplementation and aspirin use in cancer survivors. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20728343&form=6&db=m Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20803081&form=6&db=m mTOR Signaling is Involved in Indomethacin and Nimesulide Suppression of Colorectal Cancer Cell Growth via a COX-2 Independent Pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20808059&form=6&db=m The -765C allele of the cyclooxygenase-2 gene as a potential risk factor of colorectal cancer: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20824502&form=6&db=m The Expression of Both Peroxisome Proliferator-Activated Receptor Delta and Cyclooxygenase-2 in Tissues Is Associated with Poor Prognosis in Colorectal Cancer Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20837956&form=6&db=m Phase III randomized trial assessing rofecoxib in the adjuvant setting of colorectal cancer: final results of the VICTOR trial. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20846456&form=6&db=m Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20864903&form=6&db=m Expression of cyclooxygenase-2 in colonic polyps. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876365&form=6&db=m Cyclooxygenase-2 Expression in Animal Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21030497&form=6&db=m Highly purified eicosapentaenoic acid as free fatty acids strongly suppresses polyps in ApcMin/+ mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21071999&form=6&db=m Pifithrin-?, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21088406&form=6&db=m Role of cyclooxygenase-2 in pathogenesis and prevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21113620&form=6&db=m The effect of COX-2 inhibitor on capecitabine-induced hand-foot syndrome in patients with stage II/III colorectal cancer: a phase II randomized prospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21138335&form=6&db=m Formulation and development of release modulated colon targeted system of meloxicam for potential application in the prophylaxis of colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21152137&form=6&db=m Relation of the expression of cyclooxygenase-2 in colorectal adenomas and adenocarcinomas to angiogenesis and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21158711&form=6&db=m Cyclooxygenase as a Target for Colorectal Cancer Chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21163769&form=6&db=m [Application of non-steroidal anti-inflammatory drugs to enhance 5-fluorouracil efficacy in experimental systems]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21166741&form=6&db=m Promoter hypermethylation of cyclooxygenase-2 gene in esophageal squamous cell carcinoma. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205744&form=6&db=m Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21217396&form=6&db=m Dual Blockade of the EGFR and COX-2 Pathways: A Phase II Trial of Cetuximab and Celecoxib in Patients With Chemotherapy Refractory Metastatic Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21232179&form=6&db=m Expression of cyclooxygenase-2 and its relationship with mismatch repair and microsatellite instability in hereditary nonpolyposis colorectal cancer. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21251952&form=6&db=m HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21296766&form=6&db=m COX-2 Contributes to P-glycoprotein-Mediated Multidrug Resistance via phosphorylation of c-Jun at Ser63/73 in Colorectal Cancer. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21435744&form=6&db=m [Aspirin in the prevention of colorectal cancer.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21509397&form=6&db=m Digital analysis of the expression levels of multiple colorectal cancer-related genes by multiplexed digital-PCR coupled with hydrogel bead-array. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21576350&form=6&db=m Selective PGE2 Suppression Inhibits Colon Carcinogenesis and Modifies Local Mucosal Immunity. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21661398&form=6&db=m Expression of COX-2, MMP-2 and VEGF in stage II and III colorectal cancer and the clinical significance. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21666716&form=6&db=m Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21668942&form=6&db=m COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21680706&form=6&db=m Statin use and colorectal cancer risk according to molecular subtypes in two large prospective cohort studies. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21730361&form=6&db=m COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21816843&form=6&db=m Cardiovascular Risk Markers and Mechanisms in Targeting the COX Pathway for Colorectal Cancer Prevention. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21926111&form=6&db=m Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21937683&form=6&db=m ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21939759&form=6&db=m Novel selective Cox-2 inhibitors induce apoptosis in Caco-2 colorectal carcinoma cell line. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21986945&form=6&db=m Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002318&form=6&db=m A novel nitro-oxy substituted analogue of rofecoxib reduces human colon cancer cell growth. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22049153&form=6&db=m The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22066066&form=6&db=m Prognostic significance of cytosolic phospholipase A2 expression in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22086675&form=6&db=m Effect of silibinin in human colorectal cancer cells: Targeting the activation of NF-?B signaling. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22166248&form=6&db=m Urinary prostaglandin E2 metabolite and risk for colorectal adenoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22170686&form=6&db=m The role of COX-2/PGE(2) in gossypol-induced apoptosis of colorectal carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22173719&form=6&db=m PTGS2 (COX2) -765G>C gene polymorphism and risk of sporadic colorectal cancer in Iranian population. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22180364&form=6&db=m Chemopreventive effects of NSAIDs on cytokines and transcription factors during the early stages of colorectal cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22268531&form=6&db=m The nonsteroidal anti-inflammatory drug indomethacin activates the eIF2alpha kinase PKR, causing a translational block in human colorectal cancer cells. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22329897&form=6&db=m Indomethacin antagonizes EP(2) prostanoid receptor activation in LS174T human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22334096&form=6&db=m N-succinylaspart-1-yl celecoxib is a potential colon-specific prodrug of celecoxib with improved therapeutic properties. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22493349&form=6&db=m 5-aminosalicylic acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22521508&form=6&db=m The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553404&form=6&db=m Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22710400&form=6&db=m The establishment of supramolecular immunobead real-time PCR and the identification of Cox-2 as a metastasis-related marker in colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22751903&form=6&db=m Antitumor and anti-metastatic effects of cyclooxygenase-2 inhibition by celecoxib on human colorectal carcinoma xenografts in nude mouse rectum. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22843946&form=6&db=m Association Between COX-2 Expression and Effectiveness of COX-2 Inhibitors in a Phase II Trial in Patients with Metastatic Colorectal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22859375&form=6&db=m Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-?B and regulating Nrf2/HO-1 pathway. unassigned -
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22893198&form=6&db=m Mechanistic Aspects of COX-2 Expression in Colorectal Neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22893200&form=6&db=m Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22893201&form=6&db=m COX-2 Active Agents in the Chemoprevention of Colorectal Cancer. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22904679&form=6&db=m Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22929917&form=6&db=m Association of folate intake, dietary habits, smoking and COX-2 promotor -765G>C polymorphism with K-ras mutation in patients with colorectal cancer. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22950494&form=6&db=m Chemoprevention of Cancers in Gastrointestinal Tract with Cyclooxygenase 2 Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22977519&form=6&db=m Rosiglitazone and retinoic acid inhibit proliferation and induce apoptosis in the HCT-15 human colorectal cancer cell line. causal interaction,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23013454&form=6&db=m Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23033009&form=6&db=m ?-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin? causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23084580&form=6&db=m Expression of p27, COX-2, MLH1, and MSH2 in young patients with colon carcinoma and correlation with morphologic findings. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23117797&form=6&db=m Single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygenase-2-targeted optical imaging agent in a canine model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23167360&form=6&db=m Tanshinone II--a inhibits angiogenesis through down regulation of COX-2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23217168&form=6&db=m The role of chemoprevention by selective cyclooxygenase-2 inhibitors in colorectal cancer patients - a population-based study. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23222413&form=6&db=m Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23293573&form=6&db=m Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23300952&form=6&db=m Evaluation of alpha 1-antitrypsin and the levels of mRNA expression of matrix metalloproteinase 7, urokinase type plasminogen activator receptor and COX-2 for the diagnosis of colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23347845&form=6&db=m Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349017&form=6&db=m LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23359345&form=6&db=m Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b. ongoing research,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401648&form=6&db=m Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23479369&form=6&db=m Smoking and Colorectal Cancer Risk by Tumor Genetic and Epigenetic Subtypes: A Molecular Pathological Epidemiology (MPE) Study. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23479371&form=6&db=m Physical Activity, Tumor PTGS2 Expression, and Colorectal Cancer Survival: A Molecular Pathological Epidemiology (MPE) Approach. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23527044&form=6&db=m Prognostic Significance of COX-2 Immunohistochemical Expression in Colorectal Cancer: A Meta-Analysis of the Literature. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23531863&form=6&db=m An association between the PTGS2 rs5275 polymorphism and colorectal cancer risk in families with inherited non-syndromic predisposition. diagnostic usage,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23543356&form=6&db=m Effects of Jianpi Jiedu Recipe () on reversion of P-glycoprotein-mediated multidrug resistance through COX-2 pathway in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23629521&form=6&db=m Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23715757&form=6&db=m Polymorphisms in arachidonic acid metabolism-related genes and the risk and prognosis of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23810915&form=6&db=m PTGS2 (Cyclooxygenase-2) Expression and Survival among Colorectal Cancer Patients: A Systematic Review. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852449&form=6&db=m Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23898071&form=6&db=m High cyclooxygenase-2 expression is associated with advanced stages in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973650&form=6&db=m Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to G?i and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23975167&form=6&db=m Potential targets for colorectal cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24022467&form=6&db=m COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24023283&form=6&db=m Comparing the Effects of COX and Non-COX-inhibiting NSAIDs on Enhancement of Apoptosis and Inhibition of Aberrant Crypt Foci Formation in a Rat Colorectal Cancer Model. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24137401&form=6&db=m Cyclooxygenase-2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24142638&form=6&db=m Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis. causal interaction,diagnostic usage,unassigned 2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24171795&form=6&db=m EGF receptor and COX-1/COX-2 enzyme proteins as related to corresponding mRNAs in human per-operative biopsies of colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24179499&form=6&db=m Screening for novel protein targets of indomethacin in HCT116 human colon cancer cells using proteomics. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24213116&form=6&db=m The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24213465&form=6&db=m Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24220240&form=6&db=m 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24255632&form=6&db=m Progressive Increase of Regulatory T Cells and Decrease of CD8+ T Cells and CD8+ T Cells/Regulatory T Cells Ratio during Colorectal Cancer Development. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24260743&form=6&db=m Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/?-catenin and COX-2 pathways. therapeutic application,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24274457&form=6&db=m An apple oligogalactan potentiates the growth inhibitory effect of celecoxib on colorectal cancer. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24295787&form=6&db=m Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24327271&form=6&db=m Aspirin and colorectal cancer: back to the future. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24383454&form=6&db=m Over-expression of COX-2 mRNA in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24396479&form=6&db=m Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24458827&form=6&db=m "Letter to editor" in lieu of article published in Mol Biol Rep. 2012 May; 39(5):5219-24. PTGS2 (COX2) -765G>C gene polymorphism and risk of sporadic colorectal cancer in Iranian population. unassigned -
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24503782&form=6&db=m Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24516696&form=6&db=m The expression of multiple proteins as prognostic factors in colorectal cancer: cathepsin D, p53, COX-2, epidermal growth factor receptor, C-erbB-2, and Ki-67. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24519045&form=6&db=m [Detection of fecal peroxisome proliferator-activated receptor delta and cyclooxygenase 2 mRNA in screening of colorectal cancer]. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24605250&form=6&db=m Aspirin, cyclooxygenase inhibition and colorectal cancer. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24692712&form=6&db=m COX2 Inhibitor NS398 Reduces HT-29 Cell Invasiveness by Modulating Signaling Pathways Mediated by EGFR and HIF1-?. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24713293&form=6&db=m [Cyclooxygenase-2 -765G>C polymorphism and susceptibility to colorectal cancer: a meta-analysis]. diagnostic usage,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24733273&form=6&db=m Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24760190&form=6&db=m Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24791632&form=6&db=m Predictive utility of cyclo-oxygenase-2 expression by colon and rectal cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24870748&form=6&db=m The prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/ COX2) rs5277 polymorphism does not influence risk of colorectal cancer in an Iranian population. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24983372&form=6&db=m Epidermal growth factor receptor (EGFR) and prostaglandin-endoperoxide synthase 2 (PTGS2) are prognostic biomarkers for patients with resected colorectal cancer liver metastases. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24998576&form=6&db=m Associations between single nucleotide polymorphisms of COX-2 and MMP-2 genes and colorectal cancer susceptibility in the Saudi population. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25011266&form=6&db=m [Chemo-preventive effect of Angelica sinensis' supercritical extracts on AOM/DSS-induced mouse colorectal carcinoma associated with inflammation]. causal interaction,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25013352&form=6&db=m Isothiocyanate analogs targeting CD44 receptor as an effective strategy against colon cancer. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25085205&form=6&db=m CG100649, a novel COX-2 inhibitor, inhibits colorectal adenoma and carcinoma growth in mouse models. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25166592&form=6&db=m Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25169526&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in colorectal adenocarcinoma: an immunohistochemical and histopathological study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202077&form=6&db=m Prognostic markers in early-stage colorectal cancer: significance of TYMS mRNA expression. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25295109&form=6&db=m Hedgehog-glioma-associated oncogene homolog-1 signaling in colon cancer cells and its role in the celecoxib-mediated anti-cancer effect. therapeutic application,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310697&form=6&db=m Inflammation and MiR-21 pathways functionally interact to downregulate PDCD4 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25322760&form=6&db=m Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE? synthesis and COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25356658&form=6&db=m Ethyl acetate extract from Glycosmis parva leaf induces apoptosis and cell-cycle arrest by decreasing expression of COX-2 and altering BCL-2 family gene expression in human colorectal cancer HT-29 cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25368225&form=6&db=m Current concepts in colorectal cancer prevention with cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25381814&form=6&db=m STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422199&form=6&db=m MiR-1297 regulates the growth, migration and invasion of colorectal cancer cells by targeting cyclo-oxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25434139&form=6&db=m [Relationship between multi-gene proteins in colorectal carcinoma complicated with chronic schistosomiasis: an immunohistochemical study by using tissue microarray techniques]. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501829&form=6&db=m Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25503930&form=6&db=m Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25507737&form=6&db=m [Relationship between multi-gene proteins in colorectal carcinoma complicated with chronic schistosomiasis: an immunohistochemical study by using tis- sue microarray techniques]. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25610014&form=6&db=m Prognostic importance of increased cyclooxygenase-2 levels in colorectal carcinomas: a 5-year single-institution study. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25684498&form=6&db=m Parecoxib: an enhancer of radiation therapy for colorectal cancer. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25693081&form=6&db=m Is there a place for practical chemoprevention of colorectal cancer in light of COX-2 heterogeneity? causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815878&form=6&db=m Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-?B and cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25835114&form=6&db=m Cyclooxygenase-2 (COX2) gene polymorphisms and the risk of sporadic colorectal cancer and polyps among Jordanian population. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25854428&form=6&db=m Poly-?-glutamic acid induces apoptosis via reduction of COX-2 expression in TPA-induced HT-29 human colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25939395&form=6&db=m Preclinical Pharmacokinetics and Pharmacodynamics and Content Analysis of Gnetol in Foodstuffs. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26034355&form=6&db=m Expression of COX-2 and HER-2 in colorectal cancer and their correlation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26107817&form=6&db=m Simultaneous inhibition of EGFR/VEGFR and cyclooxygenase-2 targets stemness-related pathways in colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26150361&form=6&db=m Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26159723&form=6&db=m Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26220687&form=6&db=m Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-?B signalings in colorectal cancer cells. unassigned -
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251576&form=6&db=m Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26302241&form=6&db=m Low-Dose Aspirin or Nonsteroidal Anti-inflammatory Drug Use and Colorectal Cancer Risk: A Population-Based, Case-Control Study. therapeutic application,unassigned 2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303353&form=6&db=m Does miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26483874&form=6&db=m Role of retinoids in the prevention and treatment of colorectal cancer. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26497206&form=6&db=m A prognostic classifier for patients with colorectal cancer liver metastasis, based on AURKA, PTGS2 and MMP9. diagnostic usage,unassigned 2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498686&form=6&db=m Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622766&form=6&db=m Cyclooxygenase-2 gene polymorphisms and the risk of colorectal cancer: A population-based study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680965&form=6&db=m Expression of Cyclooxygenase-2 and Tumor Microvessel Density in Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707712&form=6&db=m Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870226&form=6&db=m Sinomenine, a COX-2 inhibitor, induces cell cycle arrest and inhibits growth of human colon carcinoma cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26915975&form=6&db=m In vitro antiproliferative activity of 2,3-dihydroxy-9,10-anthraquinone induced apoptosis against COLO320 cells through cytochrome c release caspase mediated pathway with PI3K/AKT and COX-2 inhibition. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931344&form=6&db=m Celecoxib induces apoptosis but up-regulates VEGF via endoplasmic reticulum stress in human colorectal cancer in vitro and in vivo. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26950454&form=6&db=m The effect of celecoxib and its combination with imatinib on human HT-29 colorectal cancer cells: Involvement of COX-2, Caspase-3, VEGF and NF-?B genes expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26957558&form=6&db=m MicroRNA MIR21 (miR-21) and PTGS2 expression in colorectal cancer and patient survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26997150&form=6&db=m The Co-regulatory Role of 5-Lipoxygenase and Cyclooxygenase-2 in the Carcinogenesis and their Promotion by Cigarette Smoking in Colons. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27039732&form=6&db=m Effects of a Multikinase Inhibitor Motesanib (AMG 706) Alone and Combined with the Selective DuP-697 COX-2 Inhibitor on Colorectal Cancer Cells. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27074568&form=6&db=m Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27075590&form=6&db=m HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27112768&form=6&db=m PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27255176&form=6&db=m Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27317138&form=6&db=m Cardiovascular effects of cyclooxygenase-2 inhibitors: a mechanistic and clinical perspective. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27407093&form=6&db=m Physical Activity and Cancer Outcomes: A Precision Medicine Approach. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27466499&form=6&db=m Expression of Endoglin and Vascular Endothelial Growth Factor as Prognostic Markers in Experimental Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27764771&form=6&db=m Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition. causal interaction,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27810226&form=6&db=m The Role of Cyclooxygenase-2 in Colorectal Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27823649&form=6&db=m Stromal COX-2 signaling are correlated with colorectal cancer: A review. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28051316&form=6&db=m Phytochemical Investigations of Three Rhodocodon (Hyacinthaceae Sensu APG II) Species. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28139497&form=6&db=m The expression and significance of feces cyclooxygensae-2 mRNA in colorectal cancer and colorectal adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28139830&form=6&db=m Low-Dose Aspirin Acetylates Cyclooxygenase-1 in Human Colorectal Mucosa: Implications for the Chemoprevention of Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28178650&form=6&db=m SerpinB3 upregulates the Cyclooxygenase-2 / ?-Catenin positive loop in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28188432&form=6&db=m Correlations of IGF-1R and COX-2 Expressions with Ras and BRAF Genetic Mutations, Clinicopathological Features and Prognosis of Colorectal Cancer Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28260506&form=6&db=m pH-Dependent Behavior of Novel Gellan Beads Loaded with Naproxen. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272681&form=6&db=m Correlation of COX- 2 Expression in Colorectal Carcinoma with Clinicopathological Features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28338176&form=6&db=m The inhibitory effect of resveratrol on COX-2 expression in human colorectal cancer: a promising therapeutic strategy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386381&form=6&db=m Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28423516&form=6&db=m The addition of celecoxib improves the antitumor effect of cetuximab in colorectal cancer: role of EGFR-RAS-FOXM1-?- catenin signaling axis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28448072&form=6&db=m Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454270&form=6&db=m FosB transcription factor regulates COX-2 expression in colorectal cancer cells without affecting PGE2 expression. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599714&form=6&db=m Effects of moderate alcohol consumption on gene expression related to colonic inflammation and antioxidant enzymes in rats. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28601236&form=6&db=m Role of cyclooxygenase-2 inhibitors in the survival outcome of colorectal cancer patients: A population-based cohort study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28786533&form=6&db=m MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28890812&form=6&db=m Cyclooxygenase-2 gene polymorphisms and susceptibility to colorectal cancer in a Brazilian population. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28934138&form=6&db=m Inhibitory Effects of Culinary Herbs and Spices on the Growth of HCA-7 Colorectal Cancer Cells and Their COX-2 Expression. ongoing research,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29037225&form=6&db=m YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29068698&form=6&db=m The Impact of Dietary Polyphenols on COX-2 Expression in Colorectal Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29158365&form=6&db=m Phase II Trial Using a Combination of Oxaliplatin, Capecitabine, and Celecoxib with Concurrent Radiation for Newly Diagnosed Resectable Rectal Cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29229353&form=6&db=m Novel 1,4-benzothazines obliterate COX-2 mediated JAK-2/STAT-3 signals with potential regulation of oxidative and metabolic stress during colorectal cancer. causal interaction,unassigned 2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29257846&form=6&db=m POLYMORPHISM OF THE COX-2 GENE AND SUSCEPTIBILITY TO COLON AND RECTAL CANCER. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29259703&form=6&db=m Prostaglandin E causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29339153&form=6&db=m TEMPORARY REMOVAL: Inhibition of COX-2 and 5-LOX regulates the progression of colorectal cancer by promoting PTEN and suppressing PI3K/AKT pathway. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29421522&form=6&db=m Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2), a complex target for colorectal cancer prevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29444936&form=6&db=m Aspirin alone and combined with a statin suppresses eicosanoid formation in human colon tissue. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552755&form=6&db=m Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29562216&form=6&db=m The effectiveness of cyclooxygenase-2 inhibitors and evaluation of angiogenesis in the model of experimental colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29617306&form=6&db=m Development of Colorectal-Targeted Dietary Supplement Tablets Containing Natural Purple Rice Bran Oil as a Colorectal Chemopreventive. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29695380&form=6&db=m Association between Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancer: A Population-Based Case-Control Study. causal interaction,unassigned 4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29763272&form=6&db=m Colorectal Cancer Screening and Prevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29769213&form=6&db=m Chemopreventive Efficacy of the Cyclooxygenase-2 (Cox-2) Inhibitor, Celecoxib, Is Predicted by Adenoma Expression of Cox-2 and 15-PGDH. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29800798&form=6&db=m Impact of structural alterations on the radiopharmacological profile of 18F-labeled pyrimidines as cyclooxygenase-2 (COX-2) imaging agents. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29874966&form=6&db=m Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior. causal interaction,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30008836&form=6&db=m Value of combined detection of serum carcino-embryonic antigen, carbohydrate antigen 19-9 and cyclooxygenase-2 in the diagnosis of colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30012671&form=6&db=m A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell-Potentiated Colorectal Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30023227&form=6&db=m Immunohistochemical expression of proinflammatory enzyme COX-2 and p53 in ulcerative colitis and its associated dysplasia and colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034467&form=6&db=m Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30106414&form=6&db=m Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients. An experience from Western Saudi Arabia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30183370&form=6&db=m Probiotics (Lactobacillus acidophilus and Lactobacillus rhamnosus GG) in Conjunction with Celecoxib (selective COX-2 inhibitor) Modulated DMH-Induced Early Experimental Colon Carcinogenesis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186819&form=6&db=m ?-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30260024&form=6&db=m Associations between the cyclooxygenase-2 expression in circulating tumor cells and the clinicopathological features of patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30269738&form=6&db=m Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT-116 cells through down-regulation of prostaglandin E2 receptor EP4. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30480806&form=6&db=m c-Met inhibition is required for the celecoxib-attenuated stemness property of human colorectal cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580092&form=6&db=m Clopidogrel and Low-Dose Aspirin, Alone or Together, Reduce Risk of Colorectal Cancer. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30596015&form=6&db=m Molecular profiling analysis for colorectal cancer patients with Pi-Xu or Shi-Re syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30622375&form=6&db=m Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30638861&form=6&db=m Expression and association of carbonic anhydrase IX and cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30656820&form=6&db=m Risks of colorectal neoplasms and cardiovascular thromboembolic events after the combined use of selective COX-2 inhibitors and aspirin with 5-year follow-up: a meta-analysis. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30665389&form=6&db=m Glucocorticoids promote the development of azoxymethane and dextran sulfate sodium-induced colorectal carcinoma in mice. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30700940&form=6&db=m Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30826660&form=6&db=m Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930224&form=6&db=m Inhibition of PSMD4 blocks the tumorigenesis of hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30941311&form=6&db=m Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980797&form=6&db=m Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31023028&form=6&db=m Acetylsalicylic Acid and its Potential for Chemoprevention of Colorectal Carcinoma. therapeutic application,unassigned 1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31205515&form=6&db=m c-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31223291&form=6&db=m Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31244287&form=6&db=m Over-Expression of Cyclooxygenase-2 in Colorectal Cancer Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31272909&form=6&db=m Vitamin D, linoleic acid, arachidonic acid and COX-2 in colorectal cancer patients in relation to disease stage, tumour localisation and disease progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31313358&form=6&db=m Population-based case-control study: chemoprotection of colorectal cancer with non-aspirin nonsteroidal anti-inflammatory drugs and other drugs for pain control. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31614548&form=6&db=m Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31725282&form=6&db=m Graphene Oxide-Based Suppression of Nonspecificity in Loop-Mediated Isothermal Amplification Enabling the Sensitive Detection of Cyclooxygenase-2 mRNA in Colorectal Cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31797003&form=6&db=m Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc am1137) rat with celecoxib. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32157241&form=6&db=m An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32168749&form=6&db=m Evaluation of Glycosylated PTGS2 in Colorectal Cancer for NSAIDS-Based Adjuvant Therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32410839&form=6&db=m The Role of Cyclooxygenase-2 in Colorectal Cancer. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32410997&form=6&db=m Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32535107&form=6&db=m Characterization of cyclooxygenase-2 acetylation and prostanoid inhibition by aspirin in cellular systems. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32646396&form=6&db=m Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655010&form=6&db=m Multi-omics Analysis Reveals Adipose-tumor Crosstalk in Patients with Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32731879&form=6&db=m COX-2 gene rs689466 polymorphism is associated with increased risk of colorectal cancer among Caucasians: a meta-analysis. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32874582&form=6&db=m Expression of cyclooxygenase-2 and mucin 1 in colorectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33040178&form=6&db=m Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33049690&form=6&db=m Role of Cyclooxygenase-2 in colorectal cancer patients. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33200275&form=6&db=m Correction to: Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega?3 polyunsaturated fatty acid eicosapentaenoic acid. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300198&form=6&db=m TGF-? acts as a dual regulator of COX-2/PGE2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/?-catenin pathways in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343354&form=6&db=m Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33427041&form=6&db=m Updates on the molecular mechanisms of aspirin in the prevention of colorectal cancer: Review. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33644686&form=6&db=m The Clinical Significance of Promoter Methylation of Fluoropyrimidine Metabolizing and Cyclooxygenase Genes in Colorectal Cancer. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33812217&form=6&db=m Oxylipin patterns in human colon adenomas. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33969138&form=6&db=m PTGS2 Over-Expression: A Colorectal Carcinoma Initiator not an Invasive Factor. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34169083&form=6&db=m Development of PET Radioligands Targeting COX-2 for Colorectal Cancer Staging, a Review of in vitro and Preclinical Imaging Studies. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34279934&form=6&db=m Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34303896&form=6&db=m Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34314467&form=6&db=m Cyclooxygenase-2 expression in colorectal carcinoma, adenomatous polyps and non-tumour bearing margins of resection tissues in a cohort of black Africans. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34436652&form=6&db=m Diclofenac down-regulates COX-2 induced expression of CD44 and ICAM-1 in human HT29 colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34526999&form=6&db=m Multi-Epitope-Based Vaccines for Colon Cancer Treatment and Prevention. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419916&form=6&db=m Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301836&form=6&db=m COX-2 inhibition in clinical cancer prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16551850&form=6&db=m Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835340&form=6&db=m Celecoxib treatment alters the gene expression profile of normal colonic mucosa. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Colorectal Neoplasms, Hereditary Nonpolyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21232179&form=6&db=m Expression of cyclooxygenase-2 and its relationship with mismatch repair and microsatellite instability in hereditary nonpolyposis colorectal cancer. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Coma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20206264&form=6&db=m Thinking outside the box about COX-1 in Alzheimer's disease. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Common Variable Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1955636&form=6&db=m Improved in vitro antigen-specific antibody synthesis in two patients with common variable immunodeficiency taking an oral cyclooxygenase and lipoxygenase inhibitor (ketoprofen). ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Common Variable Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3107119&form=6&db=m A novel arachidonic acid metabolite with stimulatory effect on PHA-induced mitogenesis of lymphocytes. unassigned -
1.14.99.1 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20685028&form=6&db=m C. albicans activates cyclooxygenase but not its product prostaglandin E? in HPV 16-stabilized cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Confusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11028754&form=6&db=m Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Confusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151910&form=6&db=m Cognitive decline with chronic meningitis secondary to a COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Confusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16803424&form=6&db=m Cardiovascular risks of cyclooxygenase inhibition. therapeutic application,unassigned 3,0
1.14.99.1 Confusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18729848&form=6&db=m Changing perceptions and practices regarding aspirin, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugs among US primary care providers. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Confusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29421522&form=6&db=m Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2), a complex target for colorectal cancer prevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4
1.14.99.1 Confusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31790610&form=6&db=m Areca nut procyanidins prevent ultraviolet light B-induced photoaging via suppression of cyclooxygenase-2 and matrix metalloproteinases in mouse skin. therapeutic application,unassigned 2,0
1.14.99.1 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6089937&form=6&db=m Platelet secretion defect associated with impaired liberation of arachidonic acid and normal myosin light chain phosphorylation. unassigned -
1.14.99.1 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8529923&form=6&db=m DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structurally related teratogens initiate the formation of 8-hydroxy-2'-deoxyguanosine in vitro and in vivo in murine maternal hepatic and embryonic tissues. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15926604&form=6&db=m COX-2 selective nonsteroidal anti-inflammatory drugs: current status. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16845338&form=6&db=m High-grade slippage of the lumbar spine in a rat model of spondylolisthesis: effects of cyclooxygenase-2 inhibitor on its deformity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236942&form=6&db=m Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. causal interaction,unassigned 4,0
1.14.99.1 Congenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21502285&form=6&db=m Embryopathic effects of thalidomide and its hydrolysis products in rabbit embryo culture: evidence for a prostaglandin H synthase (PHS)-dependent, reactive oxygen species (ROS)-mediated mechanism. unassigned -
1.14.99.1 Conjunctivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15370364&form=6&db=m Involvement of cyclooxygenase-2 in rat models of conjunctivitis. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Conjunctivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17209665&form=6&db=m Ocular adverse effects associated with systemic medications : recognition and management. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Conjunctivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663486&form=6&db=m Update on aspirin desensitization for chronic rhinosinusitis with polyps in aspirin-exacerbated respiratory disease (AERD). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Conjunctivitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8590266&form=6&db=m The pruritogenic and inflammatory effects of prostanoids in the conjunctiva. therapeutic application,unassigned 2,0
1.14.99.1 Conjunctivitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8858986&form=6&db=m Characterization of receptor subtypes involved in prostanoid-induced conjunctival pruritus and their role in mediating allergic conjunctival itching. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Conjunctivitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895602&form=6&db=m The DP receptor, allergic inflammation and asthma. unassigned -
1.14.99.1 Connective Tissue Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10943882&form=6&db=m Thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors. A report of four cases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=674349&form=6&db=m Interactions of calcium, prostaglandins and indomethacin on the smooth muscle of the bladder. unassigned -
1.14.99.1 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9253954&form=6&db=m Arachidonic acid and its metabolites are involved in the expression of morphine dependence in guinea-pig isolated ileum. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11550976&form=6&db=m Different levels of COX-1 and COX-2 enzymes in synoviocytes and chondrocytes during joint contracture formation. ongoing research,unassigned 2,0
1.14.99.1 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992095&form=6&db=m Bacterial toxin N-formyl-methionyl-leucyl-phenylalanine acutely contracts human and rabbit detrusor through the release of eicosanoids. therapeutic application,unassigned 1,0
1.14.99.1 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27776498&form=6&db=m Cyclooxygenase-2 inhibitor celecoxib attenuates joint contracture following immobilization in rat knees. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Contracture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31410880&form=6&db=m Inhibition of COX-2 Pathway as a Potential Prophylaxis Against Arthrofibrogenesis in a Rabbit Model of Joint Contracture. therapeutic application,unassigned 4,0
1.14.99.1 Corneal Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1483337&form=6&db=m Intracamerally injected platelet activating factor (PAF) induces marked intraocular inflammatory reactions. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Corneal Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2453319&form=6&db=m Modulation of immunogenic keratitis in rabbits by topical administration of inhibitors of lipoxygenase and cyclooxygenase. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Corneal Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8106842&form=6&db=m Antagonists and inhibitors of lipid mediators in experimental inflammation of the cornea. therapeutic application,unassigned 4,0
1.14.99.1 Corneal Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31233733&form=6&db=m Acute corneal injury in rabbits following nitrogen mustard ocular exposure. causal interaction,unassigned 3,0
1.14.99.1 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2473047&form=6&db=m Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat. therapeutic application,unassigned 4,0
1.14.99.1 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6155898&form=6&db=m Use of flurbiprofen to inhibit corneal neovascularization. causal interaction,unassigned 2,0
1.14.99.1 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493510&form=6&db=m Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis. ongoing research,unassigned 1,0
1.14.99.1 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10520225&form=6&db=m The effect of selective cyclooxygenase-2 inhibitor on corneal angiogenesis in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15325574&form=6&db=m Effect of COX inhibitors on VEGF-induced retinal vascular leakage and experimental corneal and choroidal neovascularization. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Corneal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051851&form=6&db=m Role of inflammatory cytokine-induced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Corneal Opacity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33237391&form=6&db=m Subconjunctival injection of tumor necrosis factor-? pre-stimulated bone marrow-derived mesenchymal stem cells enhances anti-inflammation and anti-fibrosis in ocular alkali burns. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1588937&form=6&db=m Atherosclerosis: the eicosanoid connection. ongoing research,unassigned 2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1959184&form=6&db=m Aspirin-induced decline in prostacyclin production in patients with coronary artery disease is due to decreased endoperoxide shift. Analysis of the effects of a combination of aspirin and n-3 fatty acids on the eicosanoid profile. unassigned -
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8425302&form=6&db=m Effect of aspirin on coronary collateral blood flow. causal interaction,unassigned 2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509060&form=6&db=m Risk of cardiovascular events associated with selective COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11739299&form=6&db=m Cyclooxygenase-2 blockade does not impair endothelial vasodilator function in healthy volunteers: randomized evaluation of rofecoxib versus naproxen on endothelium-dependent vasodilatation. causal interaction,unassigned 1,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12551863&form=6&db=m Selective COX-2 inhibition improves endothelial function in coronary artery disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12668895&form=6&db=m Crossreacting drugs and chemicals. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12818730&form=6&db=m Role of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors, angiotensin-converting enzyme inhibitors, cyclooxygenase-2 inhibitors, and aspirin in anti-inflammatory and immunomodulatory treatment of cardiovascular diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928948&form=6&db=m [Selective COX-2 inhibition improves endothelial function in coronary artery disease] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14642682&form=6&db=m Effect of cyclooxygenase-2 inhibition with rofecoxib on endothelial dysfunction and inflammatory markers in patients with coronary artery disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14975459&form=6&db=m Cyclooxygenase inhibition in patients with coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15116736&form=6&db=m Selective COX-2 inhibition endothelial function in coronary artery disease. Chenevard R, Hurlimann D, Bechir M et al Circulation 2003; 107: 405-09. therapeutic application,unassigned 2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655868&form=6&db=m I have coronary artery disease and osteoarthritis. What can you tell me about COX-2 inhibitors and their possible effects on my heart? ongoing research,unassigned 2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15902994&form=6&db=m Selective COX-2 inhibition with different doses of rofecoxib does not impair endothelial function in patients with coronary artery disease. therapeutic application,unassigned 3,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256872&form=6&db=m Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16493486&form=6&db=m Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. causal interaction,unassigned 1,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16702043&form=6&db=m Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism. causal interaction,unassigned 3,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16837083&form=6&db=m Cyclooxygenase-2 inhibitors dilemma in cardiovascular medicine: are all family members bad players? causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16887419&form=6&db=m Paradoxical rebound platelet activation after painkillers cessation: missing risk for vascular events? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17670526&form=6&db=m A randomized, double-blind, placebo-controlled trial of a COX-2 inhibitor (Rofecoxib) in patients undergoing coronary artery bypass surgery. causal interaction,unassigned 2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17995973&form=6&db=m P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18385811&form=6&db=m COX-2 gene promoter polymorphism and coronary artery disease in middle-aged men: the Helsinki sudden death study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18989535&form=6&db=m Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19631939&form=6&db=m Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996015&form=6&db=m Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization. diagnostic usage,unassigned 2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20207433&form=6&db=m Heterogeneity in platelet cyclooxygenase inhibition by aspirin in coronary artery disease. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21091235&form=6&db=m Interaction between COX-2 G-765C and smoking in relation to coronary artery disease in a Chinese Uighur population. therapeutic application,unassigned 1,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21256536&form=6&db=m A common promoter variant of the gene encoding cyclooxygenase-1 (PTGS1) is related to decreased incidence of myocardial infarction in patients with coronary artery disease. causal interaction,unassigned 3,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21434767&form=6&db=m The Cyclooxygenase-1 C50T Polymorphism Is Not Associated with Aspirin Responsiveness Status in Stable Coronary Artery Disease Tunisian Patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21574137&form=6&db=m Cox-2 gene polymorphism and IL-6 levels in coronary artery disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22311905&form=6&db=m Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22795340&form=6&db=m Markers of endothelial and platelet activation are associated with high on-aspirin platelet reactivity in patients with stable coronary artery disease. therapeutic application,unassigned 2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24089998&form=6&db=m Cilostazol-based triple antiplatelet therapy in the era of generic clopidogrel and new potent antiplatelet agents. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24446343&form=6&db=m PTGS2 gene polymorphism -765G>C is associated with coronary artery disease: a meta-analysis. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24513487&form=6&db=m The COX-2 rs20417 Polymorphism and Risk of Coronary Artery Disease: Evidence from 17,621 Subjects. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26221283&form=6&db=m Association of COX-2 -765G>C genetic polymorphism with coronary artery disease: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28194409&form=6&db=m A Variant in COX-2 Gene Is Associated with Left Main Coronary Artery Disease and Clinical Outcomes of Coronary Artery Bypass Grafting. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449186&form=6&db=m The risk of lower gastrointestinal bleeding in low-dose aspirin users. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28860667&form=6&db=m A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29725388&form=6&db=m MicroRNA-381 regulates the occurrence and immune responses of coronary atherosclerosis via cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31700919&form=6&db=m Predicting significance of COX-2 expression of peripheral blood monocyte in patients with coronary artery disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Coronary Artery Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34499129&form=6&db=m Persistent Incisional Pain after Noncardiac Surgery: An International Prospective Cohort Study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7482437&form=6&db=m Effect of in vitro incorporation of prostanoid precursors, superoxide radical and hydrogen peroxide on platelet function. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647575&form=6&db=m -New aspects in antithrombotic therapy--platelet inhibitors-. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10073969&form=6&db=m Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11496056&form=6&db=m Does aspirin attenuate the effect of angiotensin-converting enzyme inhibitors in hypertension or heart failure? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695251&form=6&db=m The effect of NSAIDs on the risk of coronary heart disease: fusion of clinical pharmacology and pharmacoepidemiologic data. causal interaction,unassigned 4,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12383990&form=6&db=m COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12904261&form=6&db=m Acute coronary disease Athero-Inflammation: Therapeutic approach. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767868&form=6&db=m Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719708&form=6&db=m Rationale for testing the cardiovascular risk for patients with COX-2 inhibitors on the basis of biomarker NT-proBNP. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15732722&form=6&db=m [Use of meloxicam (movalis) in patients with rheumatic diseases with concomitant coronary heart disease] diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15903352&form=6&db=m Combined lipoxygenase/cyclo-oxygenase inhibition in the elderly: the example of licofelone. therapeutic application,unassigned 2,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16190133&form=6&db=m Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16890573&form=6&db=m Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17054845&form=6&db=m [Risk factor assessment of cardiocerebrovascular diseases in patients with rheumatoid arthritis] causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350020&form=6&db=m Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African-Americans: the Atherosclerosis Risk in Communities Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17495879&form=6&db=m Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934975&form=6&db=m No case of COX-1-related aspirin resistance found in 289 patients with symptoms of stable CHD remitted for coronary angiography. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19046748&form=6&db=m Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19637402&form=6&db=m Non-aspirin NSAIDs, cyclooxygenase-2 inhibitors and risk for cardiovascular events-stroke, acute myocardial infarction, and death from coronary heart disease. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332714&form=6&db=m Functional promoter polymorphism of cyclooxygenase-2 modulates the inflammatory response in stable coronary heart disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21567652&form=6&db=m Coronary heart disease outcomes among chronic opioid and cyclooxygenase-2 users compared with a general population cohort. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435410&form=6&db=m Feverfew for migraine prophylaxis: a systematic review. causal interaction,unassigned 3,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912780&form=6&db=m Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Coronary Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399062&form=6&db=m The effect of hydroxy safflower yellow A on coronary heart disease through Bcl-2/Bax and PPAR-?. diagnostic usage,unassigned 4,0
1.14.99.1 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3127073&form=6&db=m Thromboxane synthetase inhibitors reduce infarct size by a platelet-dependent, aspirin-sensitive mechanism. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3142241&form=6&db=m Modulation of arachidonic acid metabolites and vulnerability to ventricular fibrillation during myocardial ischemia in the cat. ongoing research,unassigned 4,0
1.14.99.1 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11454603&form=6&db=m Cyclooxygenase-2 does not mediate late preconditioning induced by activation of adenosine A1 or A3 receptors. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15108967&form=6&db=m Cyclooxygenase-2 mediates ischemic, anesthetic, and pharmacologic preconditioning in vivo. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Coronary Occlusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31278427&form=6&db=m Inducible cardiac-specific overexpression of cyclooxygenase-2 (COX-2) confers resistance to ischemia/reperfusion injury. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Coronavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33496060&form=6&db=m Targeting cyclooxygenase enzyme for the adjuvant COVID-19 therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1290924&form=6&db=m Tachyphylaxis to capsaicin-induced cough and its reversal by indomethacin, in patients with the sinobronchial syndrome. causal interaction,unassigned 4,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2213552&form=6&db=m The effect of sulindac on the abnormal cough reflex associated with dry cough. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7493604&form=6&db=m Pharmacological studies of allergic cough in the guinea pig. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8575575&form=6&db=m Prostanoids and cough response to capsaicin in asthma and chronic bronchitis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8592247&form=6&db=m Putative mechanisms of cough after treatment with angiotensin converting enzyme inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11273789&form=6&db=m Effect of the cyclooxygenase-2 inhibitor celecoxib on bronchial responsiveness and cough reflex sensitivity in asthmatics. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11978928&form=6&db=m Migratory pulmonary infiltrates in a patient with rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15306209&form=6&db=m Antitussive effect of NS-398, a selective cyclooxygenase-2 inhibitor, in guinea pigs. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627674&form=6&db=m Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs. therapeutic application,unassigned 4,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19862936&form=6&db=m COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20696045&form=6&db=m Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27000801&form=6&db=m Pharmacology of bradykinin evoked coughing in guinea pigs. unassigned -
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31170972&form=6&db=m Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase. therapeutic application,unassigned 3,0
1.14.99.1 Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33614774&form=6&db=m Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil. therapeutic application,unassigned 1,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32445956&form=6&db=m Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19). therapeutic application,unassigned 1,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32566414&form=6&db=m Host transcriptome-guided drug repurposing for COVID-19 treatment: a meta-analysis based approach. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32581017&form=6&db=m Morphoproteomics and Etiopathogenic Features of Pulmonary COVID-19 with Therapeutic Implications: A Case Study. ongoing research,unassigned 2,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32583353&form=6&db=m What about COVID-19 and arachidonic acid pathway? causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32728438&form=6&db=m Safety and potential efficacy of cyclooxygenase-2 inhibitors in coronavirus disease 2019. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32837217&form=6&db=m Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury. causal interaction,unassigned 2,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32995789&form=6&db=m Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33013911&form=6&db=m Scientific Rationale for a Bottom-Up Approach to Target the Host Response in Order to Try and Reduce the Numbers Presenting With Adult Respiratory Distress Syndrome Associated With COVID-19. Is There a Role for Statins and COX-2 Inhibitors in the Prevention and Early Treatment of the Disease? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33016027&form=6&db=m Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy. causal interaction,unassigned 3,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33241658&form=6&db=m Anti-coronavirus disease 2019 (COVID-19) targets and mechanisms of puerarin. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33312125&form=6&db=m Celebrex Adjuvant Therapy on Coronavirus Disease 2019: An Experimental Study. causal interaction,unassigned 2,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441348&form=6&db=m Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33496060&form=6&db=m Targeting cyclooxygenase enzyme for the adjuvant COVID-19 therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33581688&form=6&db=m Chemical composition and pharmacological mechanism of ephedra-glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19). causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33730601&form=6&db=m Etoricoxib may inhibit cytokine storm to treat COVID-19. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751722&form=6&db=m Bioinformatic analyses hinted at augmented T helper 17 cell differentiation and cytokine response as the central mechanism of COVID-19-associated Guillain-Barré syndrome. therapeutic application,unassigned 1,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907758&form=6&db=m Cyclooxygenase inhibitor use is associated with increased COVID-19 severity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34088885&form=6&db=m Revealing the therapeutic targets and molecular mechanisms of emodin-treated coronavirus disease 2019 via a systematic study of network pharmacology. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 COVID-19 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34478955&form=6&db=m Upregulation of FOXP3 is associated with severity of hypoxia and poor outcomes in COVID-19 patients. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Cowpox http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383332&form=6&db=m Poxvirus-induced alteration of arachidonate metabolism. ongoing research,unassigned 3,0
1.14.99.1 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3938345&form=6&db=m Beneficial effects of acute intravenous ibuprofen on neurologic recovery of head-injured mice: comparison of cyclooxygenase inhibition with inhibition of thromboxane A2 synthetase or 5-lipoxygenase. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7674011&form=6&db=m Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Craniocerebral Trauma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353773&form=6&db=m The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Craniopharyngioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Creutzfeldt-Jakob Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781418&form=6&db=m Increased CSF levels of prostaglandin E(2) in variant Creutzfeldt-Jakob disease. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Creutzfeldt-Jakob Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12663931&form=6&db=m Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0
1.14.99.1 Creutzfeldt-Jakob Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612048&form=6&db=m Role of COX-2 in inflammatory and degenerative brain diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679035&form=6&db=m Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10327390&form=6&db=m Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10647629&form=6&db=m Cellular localization of cyclo-oxygenase isozymes in Crohn's disease and colorectal cancer. causal interaction,unassigned 4,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12208114&form=6&db=m Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12642362&form=6&db=m Cyclooxygenase-2 expression and role of vasoconstrictor prostanoids in small mesenteric arteries from patients with Crohn's disease. ongoing research,unassigned 2,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069531&form=6&db=m Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951496&form=6&db=m Regulated spatial distribution of cyclooxygenases and lipoxygenases in Crohn's ulcer. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17577330&form=6&db=m Expression of protease-activated receptor-1 and -2 in orofacial granulomatosis. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148357&form=6&db=m Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19594490&form=6&db=m Cyclooxygenase-2 immunoreactivity in collagenous colitis. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19711064&form=6&db=m Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality? ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20299600&form=6&db=m Novel Anti-inflammatory Functions For Endothelial and Myeloid Cyclooxygenase-2 in a New Mouse Model of Crohn's Disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21124790&form=6&db=m The functional -765G?C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24692797&form=6&db=m Role of selective cyclooxygenase-2 inhibitors in exacerbation of inflammatory bowel disease: A systematic review and meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25393372&form=6&db=m Cyclooxygenase-2 silencing for the treatment of colitis: a combined in vivo strategy based on RNA interference and engineered Escherichia coli. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Crohn Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29620794&form=6&db=m Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Cryptorchidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20671144&form=6&db=m Cyclooxygenase-2 Protects Germ Cells Against Spermatogenesis Disturbance in Experimental Cryptorchidism Model Mice. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Cryptorchidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22777528&form=6&db=m Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-?B/COX-2/PGE2. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Cystadenocarcinoma, Serous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994539&form=6&db=m FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Cystadenocarcinoma, Serous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12748469&form=6&db=m Expression of cyclooxygenase-2 in cervical, endometrial, and ovarian malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Cystadenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891188&form=6&db=m Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Cystadenoma, Serous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762637&form=6&db=m Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6785370&form=6&db=m Plasma "prorenin"-renin in Bartter's syndrome, cystic fibrosis, and chloride deficiency, and the effect of prostaglandin synthetase inhibition. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8994519&form=6&db=m Eicosanoid mediator expression in mononuclear and polymorphonuclear cells in normal subjects and patients with atopic asthma and cystic fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029317&form=6&db=m In vivo lipid peroxidation and platelet activation in cystic fibrosis. unassigned -
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169581&form=6&db=m Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15897385&form=6&db=m Aquagenic wrinkling of the palms in patients with cystic fibrosis homozygous for the delta F508 CFTR mutation. causal interaction,unassigned 4,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16517580&form=6&db=m Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis. ongoing research,unassigned 1,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18711055&form=6&db=m Expression of cyclooxygenase and lipoxygenase enzymes in sinonasal mucosa of patients with cystic fibrosis. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20403848&form=6&db=m Lipopolysaccharide induction of cyclooxygenase-2 in long-term nasal epithelial cultures in Cystic Fibrosis. ongoing research,unassigned 3,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20720307&form=6&db=m Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21605700&form=6&db=m Increased ?5- and ?6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis. unassigned -
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22185734&form=6&db=m Cyclooxygenase 2 and lipoxin A? in nasal polyps in cystic fibrosis. unassigned -
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23379606&form=6&db=m Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier. causal interaction,unassigned 4,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24080203&form=6&db=m Aquagenic wrinkling of the palms is due to vasoconstriction of palmar skin vasculature. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354807&form=6&db=m Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Cystic Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33168231&form=6&db=m Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis. therapeutic application,unassigned 3,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807670&form=6&db=m Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342898&form=6&db=m Expression of cyclooxygenase-2 in patients with bladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388444&form=6&db=m COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12526218&form=6&db=m [Expression of cyclooxygenase-2 in human transitional cell bladder carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12853844&form=6&db=m Hydrochloric acid induced changes in macrophage migration inhibitory factor in the bladder, peripheral and central nervous system of the rat. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308020&form=6&db=m Expression of cyclooxygenase-2 in dogs with cystitis. ongoing research,unassigned 2,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17382773&form=6&db=m Cyclophosphamide induced cystitis: role of nitric oxide synthase, cyclooxygenase-1 and 2, and NK(1) receptors. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17537839&form=6&db=m Expression of cyclooxygenase-2 in urinary bladder in rats with cyclophosphamide-induced cystitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638016&form=6&db=m Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats. ongoing research,unassigned 2,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18234483&form=6&db=m Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis. ongoing research,unassigned 4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18449376&form=6&db=m Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18514385&form=6&db=m Editorial Comment on: Intravesical Botulinum Toxin A Administration Inhibits COX-2 and EP4 Expression and Suppresses Bladder Hyperactivity in Cyclophosphamide-Induced Cystitis in Rats. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18514386&form=6&db=m Intravesical Botulinum Toxin A Administration Inhibits COX-2 and EP4 Expression and Suppresses Bladder Hyperactivity in Cyclophosphamide-Induced Cystitis in Rats. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18514387&form=6&db=m Editorial Comment on: Intravesical Botulinum Toxin A Administration Inhibits COX-2 and EP4 Expression and Suppresses Bladder Hyperactivity in Cyclophosphamide-Induced Cystitis in Rats. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19161536&form=6&db=m Cyclooxygenase-2 expression on urothelial and inflammatory cells of cystoscopic biopsies and urine cytology as a possible predictive marker for bladder carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19303104&form=6&db=m Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20602232&form=6&db=m Cyclooxygenase-2 contributes to functional changes seen on experimental hemorrhagic cystitis induced by ifosfamide in rat urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21396778&form=6&db=m ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. causal interaction,unassigned 2,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22577245&form=6&db=m Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22634839&form=6&db=m Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,2
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23359243&form=6&db=m Dual involvements of cyclooxygenase and nitric oxide synthase expressions in ketamine-induced ulcerative cystitis in rat bladder. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24387269&form=6&db=m Cyclooxygenase-2 and B-cell lymphoma-2 expression in cystitis glandularis and primary vesicle adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25265830&form=6&db=m The influence of piroxicam, a non-selective cyclooxygenase inhibitor, on autonomic nervous system activity in experimental cyclophosphamide-induced hemorrhagic cystitis and bladder outlet obstruction in rats. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26073037&form=6&db=m Translocation of NF-?B and expression of cyclooxygenase-2 are enhanced by ketamine-induced ulcerative cystitis in rat bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26125048&form=6&db=m Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26774808&form=6&db=m Spectral heart rate variability in rats with cyclophosphamide-induced hemorrhagic cystitis treated with cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27237019&form=6&db=m Editorial Comment to Novel strategy for cystitis glandularis: Oral treatment with cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27238955&form=6&db=m Novel strategy for cystitis glandularis: Oral treatment with cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30552456&form=6&db=m Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP1 receptor antagonist. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31257475&form=6&db=m Epigenetic regulation of COX?2 expression by DNA hypomethylation via NF??B activation in ketamine?induced ulcerative cystitis. ongoing research,unassigned 2,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31375151&form=6&db=m Lipoxygenase-5 Expression in Canine Urinary Bladder: Normal Urothelium, Cystitis and Transitional Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31467580&form=6&db=m C-Phycocyanin Alleviates Bladder Inflammation and Dysfunction in Cyclophosphamide-Induced Cystitis in a Mouse Model by Inhibiting COX-2 and EP4. causal interaction,unassigned 3,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32307385&form=6&db=m [TYPICAL TYPE CYSTITIS GLANDULARIS PRESENTING URINARY RETENTION IN A YOUNG MAN: ADJUVANT THERAPY USING ORAL CYCLOOXYGENASE-2 INHIBITOR: A CASE REPORT]. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34141803&form=6&db=m Pelvic lipomatosis with cystitis glandularis managed with cyclooxygenase-2 inhibitor: A case report. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Cystitis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12074775&form=6&db=m Efficacy of oral doxepin and piroxicam treatment for interstitial cystitis. therapeutic application,unassigned 4,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11228229&form=6&db=m Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12469191&form=6&db=m Expression of cyclooxygenase-2 and its relationship to p53 accumulation in ovarian adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14747187&form=6&db=m Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766256&form=6&db=m Cyclooxygenase-1 and 2 in normal and malignant human ovarian epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15086495&form=6&db=m Micro-MRI methods to detect renal cysts in mice. ongoing research,unassigned 3,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15871199&form=6&db=m [Expression of cylooxygenase-2 in endometriosis] diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18053993&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24296832&form=6&db=m Regression of experimentally induced endometriosis with a new selective cyclooxygenase-2 enzyme inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24744881&form=6&db=m Lithium induces microcysts and polyuria in adolescent rat kidney independent of cyclooxygenase-2. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26005470&form=6&db=m Immunohistochemical analysis of COX-2 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma: A comparative study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26995650&form=6&db=m PGE2 receptor EP3 inhibits water reabsorption and contributes to polyuria and kidney injury in a streptozotocin-induced mouse model of diabetes. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28283013&form=6&db=m [Molecular characterization of Echinococcus granulosus isolates obtained from different hosts]. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29930772&form=6&db=m Calcifying odontogenic cyst: A 26-year retrospective clinicopathological analysis and immunohistochemical study. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662341&form=6&db=m Nonselective Cyclooxygenase Inhibition Retards Cyst Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30809216&form=6&db=m Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31009406&form=6&db=m Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118754&form=6&db=m Mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Cytochrome-c Oxidase Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10487525&form=6&db=m Cyclooxygenase knockout mice: models for elucidating isoform-specific functions. ongoing research,ongoing research,therapeutic application,therapeutic application,unassigned,unassigned 2,2,1,1,0,0
1.14.99.1 Cytomegalovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867761&form=6&db=m Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Cytomegalovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31203442&form=6&db=m Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Darier Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22413864&form=6&db=m Cyclooxygenase-2 inhibition restores ultraviolet B-induced downregulation of ATP2A2/SERCA2 in keratinocytes: possible therapeutic approach of cyclooxygenase-2 inhibition for treatment of Darier disease. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2138428&form=6&db=m Physiological regulation of the renal vasopressin receptor-effector pathway in dogs. ongoing research,unassigned 2,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10358055&form=6&db=m Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. unassigned -
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390124&form=6&db=m Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications. ongoing research,unassigned 2,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10409291&form=6&db=m Regulation of cyclooxygenase-2 expression in renal medulla by tonicity in vivo and in vitro. unassigned -
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786541&form=6&db=m 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12032289&form=6&db=m 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis. therapeutic application,unassigned 1,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12113843&form=6&db=m Fatal hyperkalemia related to combined therapy with a COX-2 inhibitor, ACE inhibitor and potassium rich diet. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12482118&form=6&db=m Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in traumatic brain injury in the rat. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648158&form=6&db=m Regulation of cyclooxygenase-2 in renal medulla. unassigned -
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12709421&form=6&db=m Thioredoxin as a molecular target of cyclopentenone prostaglandins. therapeutic application,unassigned 1,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14636064&form=6&db=m An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-Delta 12,14-prostaglandin J2 on proteasome. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717913&form=6&db=m Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats. causal interaction,unassigned 4,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15644490&form=6&db=m Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16621950&form=6&db=m COX2 in a euryhaline teleost, Fundulus heteroclitus: primary sequence, distribution, localization, and potential function in gills during salinity acclimation. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18052108&form=6&db=m 15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses. unassigned -
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071320&form=6&db=m Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutics-induced apoptosis of human cervical carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19573595&form=6&db=m Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta(12,14)-prostaglandin J(2). causal interaction,unassigned 2,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20944061&form=6&db=m Nonenzymatic Free Radical-catalyzed Generation of 15-Deoxy-{Delta}12,14-Prostaglandin J2-like Compounds (Deoxy-J2-Isoprostanes) in Vivo. unassigned -
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21716255&form=6&db=m Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells. unassigned -
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22561694&form=6&db=m Prostaglandin J2 series induces the gene expression of monocyte chemoattractant protein-1 during the maturation phase of cultured adipocytes. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23877023&form=6&db=m Cyclooxygenase-2 mediates induction of the renal stanniocalcin-1 gene by arginine vasopressin. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26011133&form=6&db=m 15-Deoxy-?¹²,¹?-prostaglandin J? as an electrophilic mediator. therapeutic application,unassigned 1,0
1.14.99.1 Delirium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15232052&form=6&db=m Delirium From the COX-2 inhibitor refecoxib. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Delirium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31302641&form=6&db=m Risk factors for postoperative delirium in patients undergoing lower extremity joint arthroplasty: a retrospective population-based cohort study. therapeutic application,unassigned 3,0
1.14.99.1 Deltaretrovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10823885&form=6&db=m Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Deltaretrovirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366713&form=6&db=m Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7910004&form=6&db=m Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia. diagnostic usage,unassigned 2,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11055820&form=6&db=m COX-2-Specific inhibitors--the emergence of a new class of analgesic and anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11255454&form=6&db=m Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11461718&form=6&db=m Cyclooxygenase and Alzheimer's disease: implications for preventive initiatives to slow the progression of clinical dementia. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11754989&form=6&db=m Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12224048&form=6&db=m Contribution of prostaglandin D2 synthase to progression of renal failure and dialysis dementia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12446975&form=6&db=m From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs and cyclooxygenase in beta-amyloidosis and clinical dementia. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991384&form=6&db=m Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16001969&form=6&db=m Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16331303&form=6&db=m Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17111043&form=6&db=m Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT). ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17457030&form=6&db=m Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease: the Hisayama Study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18307244&form=6&db=m Relevance of COX-2 gene expression in dementia with lewy bodies associated with Alzheimer pathology. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18628177&form=6&db=m Supportive care of elderly patients with cancer. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Dementia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742252&form=6&db=m Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer's Disease. causal interaction,unassigned 2,0
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11271370&form=6&db=m Up-regulation of cyclooxygenase-2 in inflammatory demyelinating neuropathy. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020063&form=6&db=m Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516308&form=6&db=m The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: implications for multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20388219&form=6&db=m Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21530210&form=6&db=m Time-dependent changes in the brain arachidonic acid cascade during cuprizone-induced demyelination and remyelination. causal interaction,unassigned 1,0
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21699540&form=6&db=m The cyclooxygenase-2 pathway via the PGE(2) EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22749439&form=6&db=m Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model. unassigned -
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24095587&form=6&db=m Alterations of brain eicosanoid synthetic pathway in multiple sclerosis and in animal models of demyelination: Role of cyclooxygenase-2. unassigned -
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29495967&form=6&db=m Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy. therapeutic application,unassigned 4,0
1.14.99.1 Demyelinating Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33293848&form=6&db=m Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18565510&form=6&db=m Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1
1.14.99.1 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28317866&form=6&db=m Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Dengue http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903536&form=6&db=m Dengue Virus Induced COX-2 Signaling Is Regulated Through Nutrient Sensor GCN2. therapeutic application,unassigned 1,0
1.14.99.1 Dental Calculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18431039&form=6&db=m Pharmacological topics of bone metabolism: a novel bisphosphonate for the treatment of periodontitis. therapeutic application,unassigned 1,0
1.14.99.1 Dental Plaque http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31328126&form=6&db=m Myricetin Inhibition of Peptidoglycan-Induced COX-2 Expression in H9c2 Cardiomyocytes. ongoing research,unassigned 4,0
1.14.99.1 Dentigerous Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26005470&form=6&db=m Immunohistochemical analysis of COX-2 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma: A comparative study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Dentigerous Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123497&form=6&db=m Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2529819&form=6&db=m Pharmacological studies on dithranol-induced irritative dermatitis in mice. unassigned -
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3918037&form=6&db=m The metabolic transformations of columbinic acid and the effect of topical application of the major metabolites on rat skin. therapeutic application,unassigned 1,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429442&form=6&db=m Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice. causal interaction,unassigned 2,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21292288&form=6&db=m A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression. unassigned -
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23528213&form=6&db=m Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice. ongoing research,unassigned 2,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25466270&form=6&db=m Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice. diagnostic usage,unassigned 3,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25739980&form=6&db=m Modulation of HMGB1 translocation and RAGE/NF?B cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27028995&form=6&db=m Salidroside suppresses solar ultraviolet-induced skin inflammation by targeting cyclooxygenase-2. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28358324&form=6&db=m Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28887839&form=6&db=m Anti-inflammatory effect of Astaxanthin in phthalic anhydride-induced atopic dermatitis animal model. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29747743&form=6&db=m Anti-inflammatory effect of Centella asiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31925326&form=6&db=m Knockdown of sodium channel Nax reduces dermatitis symptoms in rabbit skin. unassigned -
1.14.99.1 Dermatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32330842&form=6&db=m Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-?B signaling. diagnostic usage,unassigned 2,0
1.14.99.1 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895602&form=6&db=m The DP receptor, allergic inflammation and asthma. unassigned -
1.14.99.1 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16842596&form=6&db=m COX-1 inhibition enhances scratching behaviour in NC/Nga mice with atopic dermatitis. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17703497&form=6&db=m Modulation of scratching behavior by silencing an endogenous cyclooxygenase-1 gene in the skin through the administration of siRNA. ongoing research,unassigned 4,0
1.14.99.1 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18769189&form=6&db=m The Asian side of asthma and allergy. causal interaction,unassigned 3,0
1.14.99.1 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23603610&form=6&db=m Reduced lipoxygenase and cyclooxygenase mediated signaling in PBMC of atopic dermatitis patients. unassigned -
1.14.99.1 Dermatitis, Atopic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34144392&form=6&db=m Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin. therapeutic application,unassigned 2,0
1.14.99.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906386&form=6&db=m A role for prostaglandins in the suppression of cutaneous cellular immunity and tumour development in benzo(a)pyrene- but not dimethylbenz(a)anthracene-treated mice. therapeutic application,unassigned 3,0
1.14.99.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2952282&form=6&db=m Suppression of the cutaneous immune response following topical application of the prostaglandin PGE2. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15914323&form=6&db=m Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis. ongoing research,unassigned 2,0
1.14.99.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930749&form=6&db=m Effect of chunghyuldan in chronic oxazolone-induced mouse dermatitis. ongoing research,unassigned 2,0
1.14.99.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17300245&form=6&db=m Repeated low-dose ultraviolet (UV) B exposures of humans induce limited photoprotection against the immune effects of erythemal UVB radiation. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18387507&form=6&db=m 17beta-Estradiol enhances expression of inflammatory cytokines and inducible nitric oxide synthase in mouse contact hypersensitivity. ongoing research,unassigned 2,0
1.14.99.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22652242&form=6&db=m Phytochemical and biological studies of bryophytes. unassigned -
1.14.99.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25638171&form=6&db=m Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities. unassigned -
1.14.99.1 Dermatitis, Contact http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25865800&form=6&db=m Fibroblasts support migration of monocyte-derived dendritic cells by secretion of PGE2 and MMP-1. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Dermatitis, Irritant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16279229&form=6&db=m [Cyclooxygenases in the skin] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Dermatofibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18201240&form=6&db=m Cyclooxygenase-2 expression in dermatofibroma and dermatofibrosarcoma protuberans. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Dermatofibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19469866&form=6&db=m Expression of retinoic acid receptor beta in dermatofibrosarcoma protuberans. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Dermatomyositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15301234&form=6&db=m The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Dermatomyositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094001&form=6&db=m Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10935533&form=6&db=m Altered endothelium-dependent and -independent hyperpolarization and endothelium-dependent relaxation in carotid arteries isolated from streptozotocin-induced diabetic rats. causal interaction,unassigned 1,0
1.14.99.1 Diabetes Complications http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14988266&form=6&db=m Molecular mechanisms of high glucose-induced cyclooxygenase-2 expression in monocytes. causal interaction,unassigned 3,0
1.14.99.1 Diabetes Insipidus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6804621&form=6&db=m Desamino-D-Arginine vasopressin induces fatty acid cyclooxygenase activity in the renal medulla of diabetes insipidus rats. ongoing research,unassigned 1,0
1.14.99.1 Diabetes Insipidus, Nephrogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080575&form=6&db=m Treatment of nephrogenic diabetes insipidus with prostaglandin synthesis inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Diabetes Insipidus, Nephrogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6782828&form=6&db=m Prostaglandin synthetase inhibitors in the treatment of nephrogenic diabetes insipidus. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Diabetes Insipidus, Nephrogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883974&form=6&db=m Treatment of congenital nephrogenic diabetes insipidus by hydrochlorothiazide and cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Diabetes Insipidus, Nephrogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16240160&form=6&db=m Efficacy of COX-2 inhibitors in a case of congenital nephrogenic diabetes insipidus. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Diabetes Insipidus, Nephrogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18216147&form=6&db=m Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Diabetes Insipidus, Nephrogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24459504&form=6&db=m Dysregulation of Renal Cyclooxygenase-2 in Rats with Lithium-induced Nephrogenic Diabetes Insipidus. ongoing research,unassigned 3,0
1.14.99.1 Diabetes Insipidus, Neurogenic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15644490&form=6&db=m Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1825454&form=6&db=m Mechanism of impaired responses of cerebral arterioles during diabetes mellitus. therapeutic application,unassigned 1,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6515648&form=6&db=m Effect of prostaglandin synthetase inhibitors on platelet aggregation and thromboxane production in diabetes mellitus. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11285308&form=6&db=m Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes. unassigned -
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11842281&form=6&db=m Cyclooxygenase 2 expression in chronic pancreatitis: correlation with stage of the disease and diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12920574&form=6&db=m Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians. causal interaction,unassigned 3,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14735296&form=6&db=m Reduction of lipopolysaccharide-induced cyclooxygenase-2 expression in diabetic arteries. ongoing research,unassigned 4,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15072968&form=6&db=m Cardiac pharmacological preconditioning with volatile anesthetics: from bench to bedside? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15668361&form=6&db=m The Effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension, osteoarthritis, and type 2 diabetes mellitus. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15885672&form=6&db=m COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. causal interaction,unassigned 2,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899741&form=6&db=m Celecoxib-induced nephrotoxicity in a renal transplant recipient. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16917094&form=6&db=m Increased cyclooxygenase-2 expression and prostaglandin-mediated dilation in coronary arterioles of patients with diabetes mellitus. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050798&form=6&db=m Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332672&form=6&db=m Up-regulation of vascular cyclooxygenase-2 in diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18400871&form=6&db=m Renal hemodynamic effect of cyclooxygenase 2 inhibition in young men and women with uncomplicated type 1 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18706904&form=6&db=m Depression of cyclooxygenase-2 induction in aortas of rats with type 1 and type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18840019&form=6&db=m NSAID Use in Individuals at Risk of Renal Adverse Events: An Observational Study to Investigate Trends in Australian Veterans. therapeutic application,unassigned 3,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19693696&form=6&db=m The effects of resveratrol on cyclooxygenase-1 and cyclooxygenase-2 mRNA and protein levels in diabetic rat kidneys. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026767&form=6&db=m Reactive oxygen species and cyclooxygenase 2-derived thromboxane A2 reduce angiotensin II type 2 receptor vasorelaxation in diabetic rat resistance arteries. ongoing research,unassigned 4,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20814070&form=6&db=m Gastric ulcer healing and stress-lesion preventive properties of pioglitazone are attenuated in diabetic rats. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22346138&form=6&db=m Evaluation of the effects of glimepiride (Amaryl) and repaglinide (novoNorm) on atherosclerosis progression in high cholesterol-fed male rabbits. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28223053&form=6&db=m Diabetes Upregulation of Cyclooxygenase 2 Contributes to Altered Coronary Reactivity After Cardiac Surgery. causal interaction,unassigned 4,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28689524&form=6&db=m Effects of Supervised Structured Aerobic Exercise Training Program on Interleukin-6, Nitric Oxide Synthase-1, and Cyclooxygenase-2 in Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30265586&form=6&db=m Glucocorticoids use in kidney transplant setting. causal interaction,unassigned 1,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30498345&form=6&db=m Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus. ongoing research,unassigned 3,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32310965&form=6&db=m Relative risk of end-stage renal disease requiring dialysis in treated ankylosing spondylitis patients compared with individuals without ankylosing spondylitis: A nationwide, population-based, matched-cohort study. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679712&form=6&db=m Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Diabetes Mellitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34239442&form=6&db=m Impaired Clinical Efficacy of Aspirin in Hypoalbuminemic Patients With Diabetes Mellitus. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Diabetes Mellitus, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3807832&form=6&db=m Effect of experimental diabetes on glomerular filtration rate and glomerular prostanoid production in the rat. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3391343&form=6&db=m Renal hemodynamics and urinary excretion of 6-keto-prostaglandin F1 alpha and thromboxane B2 in newly diagnosed type I diabetic patients. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8281985&form=6&db=m Peripheral macro- and microcirculation in short-term insulin-dependent diabetes mellitus: the role of prostaglandins in early haemodynamic changes. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449443&form=6&db=m Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873667&form=6&db=m COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11590329&form=6&db=m Direct administration of interleukin-1 and interferon-gamma to rat pancreas leads to the in vivo production of nitric oxide and expression of inducible nitric oxide synthase and inducible cyclooxygenase. ongoing research,unassigned 1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11906326&form=6&db=m Expression of cyclooxygenase-2 in intestinal goblet cells of pre-diabetic NOD mice. causal interaction,unassigned 4,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12397372&form=6&db=m Cellular distribution and contribution of cyclooxygenase COX-2 to diabetogenesis in NOD mouse. causal interaction,unassigned 2,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882915&form=6&db=m Free radicals and the pathogenesis of type 1 diabetes: beta-cell cytokine-mediated free radical generation via cyclooxygenase-2. causal interaction,unassigned 1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15882258&form=6&db=m Renal cyclooxygenase-2 in obese Zucker (fatty) rats. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15920054&form=6&db=m Type 1 diabetes is associated with increased cyclooxygenase- and cytokine-mediated inflammation. causal interaction,unassigned 1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17130490&form=6&db=m Altered monocyte cyclooxygenase response to lipopolysaccharide in type 1 diabetes. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18083781&form=6&db=m The effect of cyclooxygenase-2 inhibition on renal hemodynamic function in humans with type 1 diabetes. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18400871&form=6&db=m Renal hemodynamic effect of cyclooxygenase 2 inhibition in young men and women with uncomplicated type 1 diabetes mellitus. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18845644&form=6&db=m Endothelial dysfunction in mice with streptozotocin-induced type 1 diabetes is opposed by compensatory overexpression of cyclooxygenase-2 in the vasculature. causal interaction,unassigned 3,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236624&form=6&db=m Elevated plasma prostaglandins and acetylated histone in monocytes in Type 1 diabetes patients. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332349&form=6&db=m Renal Hyperfiltration is a Determinant of Endothelial Function Responses to Cyclooxygenase 2 Inhibition in Type 1 Diabetes. causal interaction,unassigned 1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22522619&form=6&db=m PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23134485&form=6&db=m Glycaemic variability in paediatric patients with type 1 diabetes on continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI): a cross-sectional cohort study. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23429494&form=6&db=m Nigella Sativa and Thymoquinone Suppress Cyclooxygenase-2 and Oxidative Stress in Pancreatic Tissue of Streptozotocin-Induced Diabetic Rats. ongoing research,unassigned 4,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24204704&form=6&db=m Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes. causal interaction,unassigned 1,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27815317&form=6&db=m Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy. ongoing research,unassigned 4,0
1.14.99.1 Diabetes Mellitus, Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33310423&form=6&db=m Carvedilol prevents pancreatic ?-cell damage and the development of type 1 diabetes in mice by the inhibition of proinflammatory cytokines, NF-?B, COX-2, iNOS and oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8364018&form=6&db=m Inhibition of thromboxane biosynthesis and platelet function by indobufen in type II diabetes mellitus. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11844020&form=6&db=m Prostanoid release and constrictor responses to noradrenaline in the rat mesenteric vascular bed in non-insulin-dependent diabetes mellitus. unassigned -
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12920574&form=6&db=m Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians. causal interaction,unassigned 3,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15037525&form=6&db=m Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population. causal interaction,unassigned 1,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15340111&form=6&db=m Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15668361&form=6&db=m The Effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension, osteoarthritis, and type 2 diabetes mellitus. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050798&form=6&db=m Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18706904&form=6&db=m Depression of cyclooxygenase-2 induction in aortas of rats with type 1 and type 2 diabetes mellitus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660994&form=6&db=m Immunohistochemical examination of cyclooxygenase-2 and renin in a KK-A(y) mouse model of diabetic nephropathy. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20874376&form=6&db=m Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21757024&form=6&db=m Eicosanoids, ?-cell function, and diabetes. unassigned -
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25095741&form=6&db=m Cyclooxygenase 2, toll-like receptor 4 and interleukin 1? mRNA expression in atherosclerotic plaques of type 2 diabetic patients. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26516917&form=6&db=m The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28689524&form=6&db=m Effects of Supervised Structured Aerobic Exercise Training Program on Interleukin-6, Nitric Oxide Synthase-1, and Cyclooxygenase-2 in Type 2 Diabetes Mellitus. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31196754&form=6&db=m In vitro and in silico elucidation of antidiabetic and anti-inflammatory activities of bioactive compounds from Momordica charantia L. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32629236&form=6&db=m Evaluation of cyclooxygenase oxylipins as potential biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes using targeted multiple reaction monitoring mass spectrometry. diagnostic usage,unassigned 1,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679712&form=6&db=m Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145611&form=6&db=m Potential associations between variants of genes encoding regulators of inflammation, and mediators of inflammation in type 2 diabetes and insulin resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Diabetes Mellitus, Type 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34239442&form=6&db=m Impaired Clinical Efficacy of Aspirin in Hypoalbuminemic Patients With Diabetes Mellitus. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Diabetes, Gestational http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31061324&form=6&db=m Elevated Expression of Vascular Adhesion Molecule-1, Plasminogen Activator Inhibitor-1, Cyclooxygenase-2, and Thrombomodulin in Human Umbilical Vein Endothelial Cells from Hospitalized Gestational Diabetes Mellitus Patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=823064&form=6&db=m Altered platelet function in diabetes mellitus. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080473&form=6&db=m 15-Hydroxy-5,8,11,13-eicosatetraenoic acid inhibits human vascular cyclooxygenase. Potential role in diabetic vascular disease. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15166011&form=6&db=m Lipid inflammatory mediators in diabetic vascular disease. causal interaction,unassigned 3,0
1.14.99.1 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20607198&form=6&db=m Peroxynitrite-induced nitration of cyclooxygenase-2 and inducible nitric oxide synthase promotes their binding in diabetic angiopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21745731&form=6&db=m Aspirin resistance and platelet turnover: A 25-year old issue. diagnostic usage,unassigned 2,0
1.14.99.1 Diabetic Angiopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22142668&form=6&db=m Aspirin resistance, platelet turnover, and diabetic angiopathy: a 2011 update. therapeutic application,unassigned 1,0
1.14.99.1 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22315315&form=6&db=m Cannabinoid 1 receptor promotes cardiac dysfunction, oxidative stress, inflammation, and fibrosis in diabetic cardiomyopathy. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Diabetic Foot http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27030654&form=6&db=m [Effects of San-huang-sheng-fu oil on peripheral circulatory disorders and foot ulcers in diabetic rats and the mechanisms]. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Diabetic Ketoacidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6440213&form=6&db=m Plasma prostaglandin levels and circulating fuel levels in rats with diabetic ketoacidosis: effects of cyclooxygenase inhibitors and of alpha and beta adrenergic blockade. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11285308&form=6&db=m Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes. unassigned -
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11499548&form=6&db=m Expression of cyclooxygenase-2 in the macula densa of human kidney in hypertension, congestive heart failure, and diabetic nephropathy. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164875&form=6&db=m Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14514642&form=6&db=m Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14586741&form=6&db=m Roles of connective tissue growth factor and prostanoids in early streptozotocin-induced diabetic rat kidney: the effect of aspirin treatment. unassigned -
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691350&form=6&db=m Renal cyclooxygenase-2 (COX-2). Physiological, pathophysiological, and clinical implications. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16114545&form=6&db=m [Mechanism and effect of cyclooxygenase-2 inhibitor meloxicam on the protection of diabetic nephropathy in rats] ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16380483&form=6&db=m The thromboxane receptor antagonist s18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein e-deficient mice. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508208&form=6&db=m Neuronal Nitric Oxide Synthase and Cyclooxygenase-2 in Diabetic Nephropathy of Type 2 Diabetic OLETF Rats. unassigned -
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16514433&form=6&db=m Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900219&form=6&db=m Increased cyclooxygenase-2, hyperfiltration, glomerulosclerosis, and diabetic nephropathy: put the blame on the (pro)renin receptor? unassigned -
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17184177&form=6&db=m Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17263765&form=6&db=m Expression pattern of genes in peripheral blood mononuclear cells in diabetic nephropathy. therapeutic application,unassigned 1,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18037095&form=6&db=m A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18812657&form=6&db=m Effect of losartan on cyclooxygenase-2 expression in normal human mesangial cells and kidneys of rats with diabetic nephropathy. ongoing research,unassigned 4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660994&form=6&db=m Immunohistochemical examination of cyclooxygenase-2 and renin in a KK-A(y) mouse model of diabetic nephropathy. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20854812&form=6&db=m Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-?1 pathway. causal interaction,unassigned 4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21737546&form=6&db=m Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27100703&form=6&db=m Interaction of the renin angiotensin and cox systems in the kidney. causal interaction,unassigned 4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27815317&form=6&db=m Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy. ongoing research,unassigned 4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28490532&form=6&db=m Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29154978&form=6&db=m 7-Ketocholesterol induces ROS-mediated mRNA expression of 12-lipoxygenase, cyclooxygenase-2 and pro-inflammatory cytokines in human mesangial cells: Potential role in diabetic nephropathy. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33565572&form=6&db=m HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34255857&form=6&db=m Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086957&form=6&db=m Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12145179&form=6&db=m Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. therapeutic application,unassigned 1,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16356116&form=6&db=m Peripheral nerve dysfunction in experimental diabetes is mediated by cyclooxygenase-2 and oxidative stress. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060127&form=6&db=m Effects of cyclooxygenase-2 gene inactivation on cardiac autonomic and left ventricular function in experimental diabetes. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20211601&form=6&db=m NF-kappaB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy. causal interaction,unassigned 4,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249337&form=6&db=m Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain. causal interaction,unassigned 4,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23347896&form=6&db=m SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: An insight into its mechanism for neuroprotection. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23770986&form=6&db=m Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-?B inhibition. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25317247&form=6&db=m Targeting inflammation in diabetes: Newer therapeutic options. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29094308&form=6&db=m Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway. therapeutic application,unassigned 4,0
1.14.99.1 Diabetic Neuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29966615&form=6&db=m Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets. causal interaction,unassigned 3,0
1.14.99.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821258&form=6&db=m Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821538&form=6&db=m Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15364005&form=6&db=m Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15371279&form=6&db=m Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952655&form=6&db=m Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes. ongoing research,unassigned 2,0
1.14.99.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996819&form=6&db=m CYCLO-OXYGENASE-2 EXPRESSION IN HUMAN IDIOPATHIC EPIRETINAL MEMBRANE. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26297615&form=6&db=m Beneficial effects of fenofibric acid on overexpression of extracellular matrix components, COX-2, and impairment of endothelial permeability associated with diabetic retinopathy. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Diabetic Retinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26822858&form=6&db=m High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0
1.14.99.1 diacylglycerol kinase (atp) deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16137646&form=6&db=m Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus. unassigned -
1.14.99.1 Digestive System Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20594217&form=6&db=m Potentially functional COX-2-1195G>A polymorphism increases the risk of digestive system cancers: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Digestive System Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25339021&form=6&db=m The -765G>C polymorphism in the cyclooxygenase-2 gene and digestive system cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Diverticular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24758697&form=6&db=m Role of cyclooxygenase isoforms in the altered excitatory motor pathways of human colon with diverticular disease. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11850029&form=6&db=m Enhancement of lipopolysaccharide-stimulated cyclooxygenase-2 mRNA expression and prostaglandin E2 production in gingival fibroblasts from individuals with Down syndrome. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14525795&form=6&db=m Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. causal interaction,unassigned 2,0
1.14.99.1 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16606835&form=6&db=m Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. ongoing research,unassigned 3,0
1.14.99.1 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19926569&form=6&db=m Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells. causal interaction,unassigned 4,0
1.14.99.1 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28677372&form=6&db=m Early increased density of cyclooxygenase-2 (COX-2) immunoreactive neurons in Down syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Drug Eruptions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23716804&form=6&db=m Multifocal Fixed Drug Eruption with COX-2 Inhibitor-Celecoxib. unassigned -
1.14.99.1 Drug Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12139371&form=6&db=m Celecoxib for systemic lupus erythematosus: case series and literature review of the use of NSAIDs in SLE. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Drug Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17039673&form=6&db=m Meloxicam-associated anaphylactic reaction. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Drug Resistant Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27165595&form=6&db=m [Effects of cyclooxygenase-2 selective inhibitor celecoxib on the expression of major vault protein in rats with status epilepticus]. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10091284&form=6&db=m [Preferential COX-2 inhibition: its clinical relevance for gastrointestinal non-steroidal anti-inflammatory rheumatic drug toxicity] therapeutic application,unassigned 4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11945151&form=6&db=m Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12022317&form=6&db=m Increase in lifetime adverse drug reactions, service utilization, and disease severity among patients who will start COX-2 specific inhibitors: quantitative assessment of channeling bias and confounding by indication in 6689 patients with rheumatoid arthritis and osteoarthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12054171&form=6&db=m Cyclo-oxygenase 2 function is essential for bone fracture healing. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406402&form=6&db=m [First spontaneous reports of adverse drug reactions to the new selective COX-2 non-steroid anti-inflammatory drugs] therapeutic application,unassigned 4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406403&form=6&db=m [First spontaneous reports of adverse drug reactions to the new selective COX-2 non-steroideal anti-inflammatory drugs] therapeutic application,unassigned 4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406404&form=6&db=m [First spontaneous reports of adverse drug reactions to the new selective COX-2 non-steroideal anti-inflammatory drugs] therapeutic application,unassigned 4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12445032&form=6&db=m A clinical audit of the prescribing of celecoxib and rofecoxib in Australian rural general practice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12901032&form=6&db=m Interaction of rofecoxib and celecoxib with warfarin. diagnostic usage,unassigned 1,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12921500&form=6&db=m Adverse Drug Events Involving COX-2 Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15948937&form=6&db=m Adverse drug reactions to nonsteroidal anti-inflammatory drugs, COX-2 inhibitors and paracetamol in a paediatric hospital. therapeutic application,unassigned 4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032365&form=6&db=m Palliative care pharmacotherapy literature summaries and analyses. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18690953&form=6&db=m Adverse drug reactions in hospitals: a narrative review. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19462990&form=6&db=m Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19718601&form=6&db=m [Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous] therapeutic application,unassigned 3,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23861685&form=6&db=m Cholestatic hepatitis with small duct injury associated with celecoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24694232&form=6&db=m Gene Variants and Haplotypes Modifying Transcription Factor Binding Sites in the Human Cyclooxygenase 1 and 2 (PTGS1 and PTGS2) Genes. unassigned -
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29295852&form=6&db=m Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPAR?/?-Dependent Vasodilator Pathway. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Drug-Related Side Effects and Adverse Reactions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450044&form=6&db=m Deep sequencing of prostaglandin-endoperoxide synthase (PTGE) genes reveals genetic susceptibility for cross-reactive hypersensitivity to NSAID. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Dry Eye Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18515226&form=6&db=m Comparison between two cyclooxygenase inhibitors in an experimental dry eye model in albino rabbits. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Dry Eye Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25257053&form=6&db=m Dry eye-induced CCR7+CD11b+ cell lymph node homing is induced by COX-2 activities. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Dry Socket http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21413548&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib and alveolar osteitis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Dry Socket http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21834146&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib and alveolar osteitis (Journal of the Irish Dental Association 2011; 57 (1): 50-53). unassigned -
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=112867&form=6&db=m Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists--a rat model of a human problem. ongoing research,unassigned 2,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2901276&form=6&db=m Adverse effects of drugs on the immature kidney. therapeutic application,unassigned 1,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6419199&form=6&db=m A reexamination of the role of oxygen in retrolental fibroplasia. causal interaction,unassigned 3,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6422431&form=6&db=m Studies of pulmonary prostaglandin biosynthetic and catabolic enzymes as factors in ductus arteriosus patency and closure. Evidence for a shift in products with gestational age. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093010&form=6&db=m Biphasic response of the ductus arteriosus to combined administration of indomethacin and L-NAME in fetal rats. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12917997&form=6&db=m Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. therapeutic application,unassigned 4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15263833&form=6&db=m Effects of ibuprofen and hypoxia on neutrophil apoptosis in neonates. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15731544&form=6&db=m Increased constriction of the ductus arteriosus by dexamethasone, indomethacin, and rofecoxib in fetal rats. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202923&form=6&db=m The promise of prostaglandins: have they fulfilled their potential as therapeutic targets for the delay of preterm birth? causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16689986&form=6&db=m Outcome following patent ductus arteriosus ligation in premature infants: a retrospective cohort analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17065565&form=6&db=m Attenuated cyclooxygenase-2 expression contributes to patent ductus arteriosus in preterm mice. ongoing research,unassigned 4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18254035&form=6&db=m Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. therapeutic application,unassigned 4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18764861&form=6&db=m Total serum bilirubin levels during cyclooxygenase inhibitor treatment for patent ductus arteriosus in preterm infants. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,3,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19357295&form=6&db=m Renal and Cardiovascular Characterization of COX-2 Knockdown Mice. unassigned -
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19390487&form=6&db=m Chronic in utero cyclooxygenase inhibition alters PGE2-regulated ductus arteriosus contractile pathways and prevents postnatal closure. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20153127&form=6&db=m Neurodevelopmental outcome after COX inhibitor treatment for patent ductus arteriosus. therapeutic application,unassigned 4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22065264&form=6&db=m Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22466710&form=6&db=m Does Treatment of Patent Ductus Arteriosus With Cyclooxygenase Inhibitors Affect Neonatal Regional Tissue Oxygenation? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23055850&form=6&db=m Clinical considerations for the pharmacologic management of patent ductus arteriosus with cyclooxygenase inhibitors in premature infants. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23055853&form=6&db=m Pharmacoeconomics of Surgical Interventions vs. Cyclooxygenase Inhibitors for the Treatment of Patent Ductus Arteriosus. therapeutic application,unassigned 4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23055854&form=6&db=m Common clinical and practical questions on the use of intravenous Ibuprofen lysine for the treatment of patent ductus arteriosus. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23147509&form=6&db=m Post-insult ibuprofen treatment attenuates damage to the serotonergic system after hypoxia-ischemia in the immature rat brain. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23316351&form=6&db=m A high ductal flow velocity is associated with successful pharmacological closure of patent ductus arteriosus in infants 22-27 weeks gestational age. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23351600&form=6&db=m Patent Ductus Arteriosus, Low Platelets, Cyclooxygenase Inhibitors, and Intraventricular Hemorrhage in Very Low Birth Weight Preterm Infants. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23543527&form=6&db=m Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. therapeutic application,unassigned 4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24736499&form=6&db=m Thromboxane A(2) receptor stimulation promotes closure of the rat ductus arteriosus through enhancing neointima formation. therapeutic application,unassigned 4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24894898&form=6&db=m Cyclooxygenase Inhibitors in Preterm Infants With Patent Ductus Arteriosus: Effects on Cardiac and Vascular Indices. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26299912&form=6&db=m [Paracetamol (acetaminophen) use in neonatology: a (re)appreciation of an old drug]. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28690644&form=6&db=m Individualized ibuprofen treatment using serial B-type natriuretic peptide measurement for symptomatic patent ductus arteriosus in very preterm infants. therapeutic application,unassigned 1,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29468349&form=6&db=m Prediction of Therapeutic Response to Cyclooxygenase Inhibitors in Preterm Infants with Patent Ductus Arteriosus. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29958702&form=6&db=m Evidence-based use of acetaminophen for hemodynamically significant ductus arteriosus in preterm infants. therapeutic application,unassigned 4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29967813&form=6&db=m Drug Closure of a Patent Ductus Arteriosus in An Extremely Low Birth Weight Premature Newborn. A Case Report. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30227731&form=6&db=m Comparison of efficacy of oral paracetamol versus ibuprofen for PDA closure in preterms - a prospective randomized clinical trial. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ductus Arteriosus, Patent http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31218973&form=6&db=m Vascular endothelial growth factor polymorphism rs2010963 status does not affect patent ductus arteriosus incidence or cyclooxygenase inhibitor treatment success in preterm infants. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Dumping Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17419241&form=6&db=m Comprehensive investigations of quality of life after esophagectomy with special reference to the route of reconstruction. diagnostic usage,unassigned 4,0
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3131076&form=6&db=m Role of prostanoids in experimental duodenal ulcer in rat. ongoing research,unassigned 3,0
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3630020&form=6&db=m [Characteristics of prostanoid synthesis in patients with duodenal ulcer complicated by a history of hemorrhage] diagnostic usage,unassigned 1,0
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6426038&form=6&db=m Prostaglandins and vagal stimulation of gastric secretion in duodenal ulcer patients. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10929893&form=6&db=m Who needs prophylaxis of nonsteroidal anti-inflammatory drug-induced ulcers and what is optimal prophylaxis? unassigned -
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11109595&form=6&db=m [Non-steroidal anti-inflammatory agents with selective inhibitory activity on cyclooxygenase-2. Interest and future prospects] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11123029&form=6&db=m Therapy of rheumatoid arthritis: new developments and trends. therapeutic application,unassigned 4,0
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12481160&form=6&db=m Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15909598&form=6&db=m Cyclooxygenase-2 inhibitor-associated minimal-change disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23008503&form=6&db=m Cyclooxygenase (COX)-1 and COX-2 both play an important role in the protection of the duodenal mucosa in cats. therapeutic application,unassigned 2,0
1.14.99.1 Duodenal Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056333&form=6&db=m [Recommendation for the prevention and treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal ulcers and its complications]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Duodenogastric Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729118&form=6&db=m Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Duodenogastric Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17031101&form=6&db=m Gastroesophageal reflux disease. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Duodenogastric Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18646190&form=6&db=m Chemoprevention of glandular stomach carcinogenesis through duodenogastric reflux in rats by a COX-2 inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Duodenogastric Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19110997&form=6&db=m A selective cyclooxygenase-2 inhibitor prevents inflammation-related squamous cell carcinogenesis of the forestomach via duodenogastric reflux in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Duodenogastric Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743684&form=6&db=m Late administration of a specific COX-2 inhibitor does not treat and/or prevent progression of gastric tumors in rats submitted to duodenogastric reflux procedure. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Dyskinesias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26009769&form=6&db=m Are cyclooxygenase-2 and nitric oxide involved in the dyskinesia of Parkinson's disease induced by L-DOPA? causal interaction,unassigned 3,0
1.14.99.1 Dyskinesias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27016022&form=6&db=m Ibuprofen or piroxicam protects nigral neurons and delays the development of L-dopa induced dyskinesia in rats with experimental Parkinsonism: influence on angiogenesis. therapeutic application,unassigned 1,0
1.14.99.1 Dyskinesias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751546&form=6&db=m Doxycycline and its derivative, COL-3, decrease dyskinesia induced by l-DOPA in hemiparkinsonian rats. unassigned -
1.14.99.1 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980343&form=6&db=m Aging associated with mild dyslipidemia reveals that COX-2 preserves dilation despite endothelial dysfunction. causal interaction,unassigned 3,0
1.14.99.1 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449186&form=6&db=m The risk of lower gastrointestinal bleeding in low-dose aspirin users. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Dyslipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34070757&form=6&db=m Effects of Anthocyanins on Vascular Health. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Dyspareunia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309818&form=6&db=m COX-2 overexpression in peritoneal lesions is correlated with nonmenstrual chronic pelvic pain. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Dyspnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8727270&form=6&db=m The influence of misoprostol (synthetic analogue of prostaglandin E1) on aspirin-induced bronchoconstriction in aspirin-sensitive asthma. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Dyspnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520726&form=6&db=m Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Dyspnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11978928&form=6&db=m Migratory pulmonary infiltrates in a patient with rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Dyspnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519889&form=6&db=m Analgesics. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Dystocia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33830296&form=6&db=m Do uterine PTGS2, PGFS, and PTGFR expression play a role in canine uterine inertia? ongoing research,unassigned 2,0
1.14.99.1 Earache http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22814005&form=6&db=m Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29109760&form=6&db=m Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31378878&form=6&db=m Correlation analysis between COX-2 gene polymorphism and eclampsia. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Ectromelia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33454433&form=6&db=m New insights into the obligatory nature of cyclooxygenase-2 and PGE2 during early chick embryogenesis. therapeutic application,unassigned 1,0
1.14.99.1 Edema, Cardiac http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7249259&form=6&db=m Beneficial actions of a free radical scavenger in traumatic shock and myocardial ischemia. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3500026&form=6&db=m A sulphonamido-indanone derivative CGP 28237 (ZK 34228), a novel non-steroidal anti-inflammatory agent without gastro-intestinal ulcerogenicity in rats. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9681783&form=6&db=m The role of endothelin-1 as a mediator of the pressure response after air embolism in blood perfused lungs. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16148826&form=6&db=m Massive pulmonary embolus without hypoxemia. causal interaction,unassigned 3,0
1.14.99.1 Embolism, Air http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9074961&form=6&db=m Mechanisms of stimulation of vagal pulmonary C fibers by pulmonary air embolism in dogs. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10078970&form=6&db=m Upregulation of COX-2 and CGRP expression in resident cells of the Borna disease virus-infected brain is dependent upon inflammation. causal interaction,unassigned 4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10480491&form=6&db=m TNFalpha-induced cyclooxygenase 2 not only increases the vasopermeability of blood-brain barrier but also enhances the neutrophil survival in Escherichia coli-induced brain inflammation. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10560661&form=6&db=m In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines. ongoing research,unassigned 4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10604752&form=6&db=m Divergence of brain prostaglandin H synthase activity and oxidative damage in mice with encephalitis. ongoing research,unassigned 3,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11021993&form=6&db=m NSAID treatment suppresses VSV propagation in mouse CNS. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12225870&form=6&db=m Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12654342&form=6&db=m The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552702&form=6&db=m Experimental brain inflammation and neurodegeneration as model of Alzheimer's disease: protective effects of selective COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15183459&form=6&db=m Benzo[a]pyrene diol epoxide up-regulates COX-2 expression through NF-kappaB in rat astrocytes. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16775385&form=6&db=m Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain. unassigned -
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818793&form=6&db=m Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia. causal interaction,unassigned 4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006935&form=6&db=m An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22016518&form=6&db=m Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22157616&form=6&db=m Lentiviral infection of rhesus macaques causes long-term injury to cortical and hippocampal projections of prostaglandin-expressing cholinergic basal forebrain neurons. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401547&form=6&db=m Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23446007&form=6&db=m Neonatal Systemic Exposure to Lipopolysaccharide Enhances Susceptibility of Nigrostriatal Dopaminergic Neurons to Rotenone Neurotoxicity in Later Life. causal interaction,unassigned 1,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23485816&form=6&db=m Celecoxib attenuates systemic lipopolysaccharide-induced brain inflammation and white matter injury in the neonatal rats. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23561827&form=6&db=m Celecoxib reduces brain dopaminergic neuronaldysfunction, and improves sensorimotor behavioral performance in neonatal rats exposed to systemic lipopolysaccharide. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24287977&form=6&db=m Upregulation of COX-2/PGE2 by ET-1 Mediated Through Ca(2+)-Dependent Signals in Mouse Brain Microvascular Endothelial Cells. ongoing research,unassigned 3,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24446952&form=6&db=m Cyclooxygenase-2 in epilepsy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24455696&form=6&db=m Role of redox signaling in neuroinflammation and neurodegenerative diseases. unassigned -
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25600211&form=6&db=m Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26177578&form=6&db=m Chronic Brain Inflammation: The Neurochemical Basis for Drugs to Reduce Inflammation. causal interaction,unassigned 1,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713336&form=6&db=m Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30303592&form=6&db=m Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30863452&form=6&db=m Systems Pharmacology-Based Approach to Comparatively Study the Independent and Synergistic Mechanisms of Danhong Injection and Naoxintong Capsule in Ischemic Stroke Treatment. unassigned -
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32632914&form=6&db=m Radiosynthesis and evaluation of [18F]FMTP, a COX-2 PET ligand. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Encephalitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33228717&form=6&db=m The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling. causal interaction,unassigned 3,0
1.14.99.1 Encephalomalacia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8462729&form=6&db=m Lipoxygenase and other enzymes of arachidonic acid metabolism in the brain of chicks affected by nutritional encephalomalacia. unassigned -
1.14.99.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10229132&form=6&db=m Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15722060&form=6&db=m Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. ongoing research,unassigned 3,0
1.14.99.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516308&form=6&db=m The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: implications for multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835249&form=6&db=m Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17442406&form=6&db=m COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression. therapeutic application,unassigned 2,0
1.14.99.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20388219&form=6&db=m Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21667309&form=6&db=m Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). unassigned -
1.14.99.1 Encephalomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23847198&form=6&db=m Intravenous immunoglobulin expands regulatory T cells via induction of cyclooxygenase-2-dependent prostaglandin E2 in human dendritic cells. therapeutic application,unassigned 2,0
1.14.99.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10229132&form=6&db=m Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10854644&form=6&db=m Glia-T cell dialogue. ongoing research,unassigned 3,0
1.14.99.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15722060&form=6&db=m Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. ongoing research,unassigned 3,0
1.14.99.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16418805&form=6&db=m COX-2 Inhibitors Modulate IL-12 Signaling Through JAK-STAT Pathway Leading to Th1 Response in Experimental Allergic Encephalomyelitis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835249&form=6&db=m Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17442406&form=6&db=m COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression. therapeutic application,unassigned 2,0
1.14.99.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21667309&form=6&db=m Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). unassigned -
1.14.99.1 Encephalomyelitis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23847198&form=6&db=m Intravenous immunoglobulin expands regulatory T cells via induction of cyclooxygenase-2-dependent prostaglandin E2 in human dendritic cells. therapeutic application,unassigned 2,0
1.14.99.1 End Stage Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27580512&form=6&db=m Role of cyclooxygenase isoforms in encephalopathy of cirrhotic rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Endocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2409135&form=6&db=m Cellular immunity in Q fever: modulation of responsiveness by a suppressor T cell-monocyte circuit. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Endocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31328126&form=6&db=m Myricetin Inhibition of Peptidoglycan-Induced COX-2 Expression in H9c2 Cardiomyocytes. ongoing research,unassigned 4,0
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11957147&form=6&db=m Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209724&form=6&db=m Cyclooxygenase-2 expression in endometrial carcinoma: correlation with clinicopathologic parameters and clinical outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14625126&form=6&db=m Cyclooxygenase-2 expression in the endometrium at the end of 2 years' continuous combined hormone replacement therapy. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863148&form=6&db=m Estrogen and progesterone receptors and cyclooxygenase-2 expression in endometrial cancer, endometrial hyperplasia, and normal endometrium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030351&form=6&db=m COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17354612&form=6&db=m Cyclooxygenase-2 (COX-2) expression in human endometrial carcinoma and precursor lesions and its possible use in cancer chemoprevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21573795&form=6&db=m The cancer marker neutrophil gelatinase-associated lipocalin is highly expressed in human endometrial hyperplasia. causal interaction,unassigned 3,0
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23603367&form=6&db=m Predictive ability of estrogen receptor (ER), progesterone receptor (PR), COX-2, Mlh1, and Bcl-2 expressions for regression and relapse of endometrial hyperplasia treated with LNG-IUS: a prospective cohort study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24436266&form=6&db=m NF-?B and COX-2 expression in nonmalignant endometrial lesions and cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Endometrial Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25662613&form=6&db=m Does Uterine Prolapse Alter Endometrial Cyclooxygenase 2 Expression and Promote the Development of Premalignant Lesions? causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11957147&form=6&db=m Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12100758&form=6&db=m JTE-522, a selective COX-2 inhibitor, inhibits cell proliferation and induces apoptosis in RL95-2 cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209724&form=6&db=m Cyclooxygenase-2 expression in endometrial carcinoma: correlation with clinicopathologic parameters and clinical outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12411038&form=6&db=m Cyclooxyenase-2 expression in endometrium carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523498&form=6&db=m The expression of cyclooxygenase-1 and -2 in proliferative endometrium and endometrial adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15016316&form=6&db=m Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067356&form=6&db=m Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15342458&form=6&db=m Cyclooxygenase-2 and p53 expressions in endometrial cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546508&form=6&db=m Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15598938&form=6&db=m Clinical implications of expression of cyclooxygenase-2 related to angiogenesis in uterine endometrial cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15609300&form=6&db=m Role of cyclooxygenase-2 in immunomodulation and prognosis of endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15703831&form=6&db=m Significant anti-proliferation of human endometrial cancer cells by combined treatment with a selective COX-2 inhibitor NS398 and specific MEK inhibitor U0126. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15750198&form=6&db=m Expression of cyclooxygenase-2 and inducible nitric oxide synthase correlates with tumor angiogenesis in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809736&form=6&db=m Expression of cyclooxygenase-2 in uterine endometrial cancer and anti-tumor effects of a selective COX-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15846217&form=6&db=m Correlation of cyclooxygenase-2 (COX-2) and aromatase expression in human endometrial cancer: tissue microarray analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863148&form=6&db=m Estrogen and progesterone receptors and cyclooxygenase-2 expression in endometrial cancer, endometrial hyperplasia, and normal endometrium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870083&form=6&db=m Cyclooxygenase inhibitors may be more effective in hormone-dependent endometrial cancers: interaction between cyclooxygenase and aromatase. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944924&form=6&db=m Clinicopathologic and prognostic significance of cyclooxygenase-2 expression in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15979129&form=6&db=m Expression of cyclooxygenase-2 (COX-2), receptors for estrogen (ER), and progesterone (PR), p53, ki67, and neu protein in endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15991524&form=6&db=m Expression of cyclooxygenase-2 in endometrial adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16302726&form=6&db=m Multiple roles of cyclooxygenase-2 in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16430474&form=6&db=m Cell cycle regulators and apoptosis-associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16527278&form=6&db=m Expression of metalloproteinases 2 and 9 and cyclooxygenase 2 in endometrial carcinoma. diagnostic usage,unassigned 1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16884383&form=6&db=m Overexpression of cyclooxygenase-2 correlates with tumor angiogenesis in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16963204&form=6&db=m Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030351&form=6&db=m COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17044934&form=6&db=m Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17195456&form=6&db=m Expression of Tn and sialyl-Tn antigens in endometrial cancer: its relationship with tumor-produced cyclooxygenase-2, tumor-infiltrated lymphocytes and patient prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17354612&form=6&db=m Cyclooxygenase-2 (COX-2) expression in human endometrial carcinoma and precursor lesions and its possible use in cancer chemoprevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17380299&form=6&db=m The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624083&form=6&db=m Expression of gelatinase (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) in endometrial carcinoma. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17970040&form=6&db=m Cyclooxygenase-2 expression correlates with apoptosis and angiogenesis in endometrial cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097584&form=6&db=m Hepatocyte growth factor induces anoikis resistance by up-regulation of cyclooxygenase-2 expression in uterine endometrial cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18204294&form=6&db=m Correlative expression of cyclooxygenase-1 (cox-1) and human epidermal growth factor receptor type-2 (her-2) in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18416056&form=6&db=m [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18505747&form=6&db=m Cyclooxygenase-2 in Cancer and Angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19051809&form=6&db=m Immunohistochemical expression of MMP-2, MMP-9 and COX-2 in Stage IA malignant polyps of the endometrium. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19154413&form=6&db=m Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19407554&form=6&db=m Proteomics reveals protein profile changes in cyclooxygenase-2 inhibitor-treated endometrial cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509570&form=6&db=m Aromatase, cyclooxygenase 2, HER-2/neu, and p53 as prognostic factors in endometrioid endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19756737&form=6&db=m Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19789507&form=6&db=m Expression of mTOR protein and its clinical significance in endometrial cancer. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20019776&form=6&db=m [Expression and function of cyclooxygenase-2 in endometrial carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20598038&form=6&db=m The relationship of COX-2 expression with estrogen receptor, progesterone receptor and prognostic parameters in endometrial carcinomas. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21431842&form=6&db=m Effects of a selective COX-2 inhibitor in patients with uterine endometrial cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21687953&form=6&db=m Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21735695&form=6&db=m [Disturbance of gene expression in endometrial cancer as therapy aim]. causal interaction,unassigned 3,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21816851&form=6&db=m Oxytocin Increases Invasive Properties of Endometrial Cancer Cells Through Phosphatidylinositol 3-Kinase/AKT-Dependent Up-Regulation of Cyclooxygenase-1, -2 and X-Linked Inhibitor of Apoptosis Protein. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22846758&form=6&db=m The effects of the selective cyclooxygenase-2 inhibitor on endometrial cytological findings in uterine endometrial cancer patients. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625281&form=6&db=m Expression of estrogen receptors (?, ?), cyclooxygenase-2 and aromatase in normal endometrium and endometrioid cancer of uterus. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23729350&form=6&db=m Utility of Ki-67, p53, Bcl-2, and Cox-2 biomarkers for low-grade endometrial cancer and disordered proliferative/benign hyperplastic endometrium by imprint cytology. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23873111&form=6&db=m Altered expression of ERs, aromatase, and COX2 connected to estrogen action in type 1 endometrial cancer biology. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24100466&form=6&db=m Overcoming paclitaxel resistance in uterine endometrial cancer using a COX-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24436266&form=6&db=m NF-?B and COX-2 expression in nonmalignant endometrial lesions and cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25058027&form=6&db=m Mammalian target of rapamycin complex 1 and cyclooxygenase 2 pathways cooperatively exacerbate endometrial cancer. unassigned -
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25683901&form=6&db=m Immunohistochemical Expression of Cyclooxygenase-2 (COX-2) in Feline Endometrial Adenocarcinoma and in Normal and Hyperplastic Endometria. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25872333&form=6&db=m Effect of lentivirus mediated cyclooxygenase-2 gene shorthairpinRNA on invasiveness of endometrial carcinoma. ongoing research,unassigned 4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25900875&form=6&db=m Polymorphisms in cyclooxygenase-2 gene in endometrial cancer patients. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26101475&form=6&db=m Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26111272&form=6&db=m Intratumoral CD8+ Lymphocyte Infiltration as a Prognostic Factor and Its Relationship With Cyclooxygenase 2 Expression and Microsatellite Instability in Endometrial Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26468779&form=6&db=m Elevation of ?-3 Polyunsaturated Fatty Acids Attenuates PTEN-deficiency Induced Endometrial Cancer Development through Regulation of COX-2 and PGE2 Production. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546977&form=6&db=m Bisphenol A-induced epithelial to mesenchymal transition is mediated by cyclooxygenase-2 up-regulation in human endometrial carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474124&form=6&db=m Expressions and clinical significance of COX-2, VEGF-C, and EFGR in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29404887&form=6&db=m MicroRNA-101 inhibits angiogenesis via COX-2 in endometrial carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30168128&form=6&db=m Integrated eicosanoid lipidomics and gene expression reveal decreased prostaglandin catabolism and increased 5-lipoxygenase expression in aggressive subtypes of endometrial cancer. causal interaction,unassigned 2,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30488858&form=6&db=m To evaluate immunoreactivity of cyclooxygenase-2 in cases of endometrial carcinoma and correlate it with expression of p53 and vascular endothelial growth factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930224&form=6&db=m Inhibition of PSMD4 blocks the tumorigenesis of hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31533599&form=6&db=m Variances in the level of of COX-2 and iNOS in different grades of endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32154162&form=6&db=m Cyclooxygenase-2 and ?-Catenin as Potential Diagnostic and Prognostic Markers in Endometrial Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32174282&form=6&db=m Prospects of NSAIDs administration as double-edged agents against endometrial cancer and pathological species of the uterine microbiome. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32363546&form=6&db=m COX-2-PGE2-EPs in gynecological cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32433831&form=6&db=m Expression of cyclooxygenase-2 in imprint smears of endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903705&form=6&db=m Prognostic and Clinical Significance of Cyclooxygenase-2 Overexpression in Endometrial Cancer: A Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Endometrial Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33224882&form=6&db=m Corrigendum: Cyclooxygenase-2 and ?-Catenin as Potential Diagnostic and Prognostic Markers in Endometrial Cancer. causal interaction,diagnostic usage,unassigned 2,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1695815&form=6&db=m Immunohistochemical localization of prostaglandin H synthase in the female reproductive tract and endometriosis. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554365&form=6&db=m Peritoneal fluid eicosanoids in chronic pelvic pain. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10782578&form=6&db=m Leukotrienes in gynaecology: the hypothetical value of anti-leukotriene therapy in dysmenorrhoea and endometriosis. therapeutic application,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11228229&form=6&db=m Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12322896&form=6&db=m Increased expression of cyclooxygenase-2 in local lesions of endometriosis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468643&form=6&db=m Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12858113&form=6&db=m Immunomodulators and aromatase inhibitors: are they the next generation of treatment for endometriosis? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14505259&form=6&db=m [COX-2-expression in extragenital endometriosis lesions as a novel therapeutical approach?] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14747187&form=6&db=m Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14998974&form=6&db=m Role of IL-18 in pathogenesis of endometriosis. ongoing research,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15294376&form=6&db=m The treatment with a COX-2 specific inhibitor is effective in the management of pain related to endometriosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15474083&form=6&db=m Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofecoxib. ongoing research,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15483103&form=6&db=m Distinct regulation of cyclooxygenase-2 by interleukin-1beta in normal and endometriotic stromal cells. causal interaction,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15533352&form=6&db=m Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium. causal interaction,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15567877&form=6&db=m Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15589867&form=6&db=m Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15871199&form=6&db=m [Expression of cylooxygenase-2 in endometriosis] diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15979990&form=6&db=m Increased cyclooxygenase-2 expression is associated with better clinical outcome in patients submitted to complete ablation for severe endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16037111&form=6&db=m GnRH II as a possible cytostatic regulator in the development of endometriosis. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16157442&form=6&db=m Aromatase inhibitors and cyclooxygenase-2 (COX-2) inhibitors in endometriosis: new questions--old answers? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309818&form=6&db=m COX-2 overexpression in peritoneal lesions is correlated with nonmenstrual chronic pelvic pain. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456945&form=6&db=m Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16961927&form=6&db=m Immunohistochemical analysis of an ectopic endometriosis in the uterine round ligament. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16962108&form=6&db=m A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis xenografts via antiangiogenic activity in severe combined immunodeficiency mice. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17081538&form=6&db=m Selective cyclo-oxygenase-2 inhibition induces regression of autologous endometrial grafts by down-regulation of vascular endothelial growth factor-mediated angiogenesis and stimulation of caspase-3-dependent apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17090383&form=6&db=m Effects of Yiweining recipe on expressions of metalloproteinase-2 and cyclooxygenase-2 mRNAs in ectopic endometrium of rats with endometriosis. ongoing research,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17156191&form=6&db=m Expression of glycodelin and cyclooxygenase-2 in human endometrial tissue following three-dimensional culture. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17295901&form=6&db=m Expression of inducible microsomal prostaglandin E synthase in local lesions of endometriosis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17296257&form=6&db=m Suppression of IL-1beta-induced COX-2 expression by trichostatin A (TSA) in human endometrial stromal cells. unassigned -
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17582405&form=6&db=m Regression of endometrial explants in a rat model of endometriosis treated with melatonin. ongoing research,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18039779&form=6&db=m Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. causal interaction,unassigned 3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18048499&form=6&db=m Inflammatory status influences aromatase and steroid receptor expression in endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18053993&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in ovarian endometriotic cysts and their relationship with angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367179&form=6&db=m Cyclooxygenase-2 overexpression in ovarian endometriomas is associated with higher risk of recurrence. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18393858&form=6&db=m Non-steroidal targets in the diagnosis and treatment of endometriosis. causal interaction,unassigned 3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18716040&form=6&db=m Effects of a selective cyclooxygenase-2 inhibitor on endometrial epithelial cells from patients with endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18722604&form=6&db=m Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18831212&form=6&db=m [Inhibitory effects of Sanlengwan on aromatase and cyclooxygenase-2 in rats of endometriosis] ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18930197&form=6&db=m A functional promoter polymorphism in interleukin-10 gene influences susceptibility to endometriosis. ongoing research,unassigned 3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19299454&form=6&db=m Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: involvement of novel kinase signaling pathways. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19401614&form=6&db=m Gonadotropin-Releasing Hormone Agonist Reduces Aromatase Cytochrome P450 and Cyclooxygenase-2 in Ovarian Endometrioma and Eutopic Endometrium of Patients with Endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,3
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19647233&form=6&db=m Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19804039&form=6&db=m Selective estrogen-receptor modulators and aromatase inhibitors: promising new medical therapies for endometriosis? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917472&form=6&db=m Cyclooxygenase-2 expression, Ki-67 labeling index, and perifocal neovascularization in endometriotic lesions. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20023295&form=6&db=m Expression of eicosanoid biosynthetic and catabolic enzymes in peritoneal endometriosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20047585&form=6&db=m Leptin on peritoneal macrophages of patients with endometriosis. causal interaction,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20056215&form=6&db=m A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20068324&form=6&db=m Expression of cyclooxygenase-2 in eutopic endometrium and ovarian endometriotic tissue in women with severe endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20112494&form=6&db=m Effect of Yikun Neiyi Wan on the expression of aromatase P450, COX-2, and ER related receptor in endometrial cells in vitro from patients with endometriosis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20537326&form=6&db=m Implication of the RAGE-EN-RAGE axis in endometriosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20567147&form=6&db=m Expression of COX-2 in intestinal endometriosis to: Tokyol C, et al. Int J Gynecol Pathol 2009;28:148-56. unassigned -
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20677482&form=6&db=m Tumor necrosis factor-alpha-induced cyclooxygenase-2 overexpression in eutopic endometrium of women with endometriosis by stromal cell culture through nuclear factor-kappaB activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20937742&form=6&db=m Expression and possible role of non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in the human endometrium and endometriosis. ongoing research,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21145050&form=6&db=m Peritoneal fluid of patients with endometriosis promotes proliferation of endometrial stromal cells and induces COX-2 expression. causal interaction,unassigned 3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21247731&form=6&db=m The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21601196&form=6&db=m Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21613300&form=6&db=m Hypoxia induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human endometrial cells. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21614520&form=6&db=m Identification of common mechanisms between endometriosis and ovarian cancer. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21762900&form=6&db=m Interleukin-1? induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian endometrioma. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22276910&form=6&db=m Identification of endometriosis-related genes by representational difference analysis of cDNA. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22402211&form=6&db=m Therapeutic potential of andrographolide for treating endometriosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22587873&form=6&db=m Cyclooxygenase-2 ( COX -2) Gene-765G/C Polymorphism and Advanced-Stage Endometriosis in Korean Women. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22608095&form=6&db=m DNA hypomethylation of the COX-2 gene promoter is associated with up-regulation of its mRNA expression in eutopic endometrium of endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22638210&form=6&db=m Inhibition of IDO1 suppresses cyclooxygenase-2 and matrix metalloproteinase-9 expression and decreases proliferation, adhesion and invasion of endometrial stromal cells. unassigned -
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22662209&form=6&db=m Angiotensin II activates the calcineurin/NFAT signaling pathway and induces cyclooxygenase-2 expression in rat endometrial stromal cells. causal interaction,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23148086&form=6&db=m Anastrozole and celecoxib for endometriosis treatment, good to keep them apart? ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23181530&form=6&db=m Role of inflammation and aromatase expression in the eutopic endometrium and its relationship with the development of endometriosis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23239446&form=6&db=m Stretch magnitude- and frequency-dependent cyclooxygenase 2 and prostaglandin E2 up-regulation in human endometrial stromal cells: possible implications in endometriosis. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23252918&form=6&db=m Relationship between Toll-like receptor-4 and mPGES-1 gene expression in local lesions of endometriosis patients. ongoing research,unassigned 2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23619346&form=6&db=m The effects of ulipristal on Bax/Bcl-2, cytochrome C, Ki-67 and cyclooxygenase-2 expression in a rat model with surgically induced endometriosis. ongoing research,unassigned 4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23962610&form=6&db=m Ovarian cancers arising from endometriosis: A microenvironmental biomarker study including ER, HNF1ß, p53, PTEN, BAF250a, and COX-2. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24133591&form=6&db=m MAPK/ERK signal pathway involved expression of COX-2 and VEGF by IL-1? induced in human endometriosis stromal cells in vitro. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24296832&form=6&db=m Regression of experimentally induced endometriosis with a new selective cyclooxygenase-2 enzyme inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24423291&form=6&db=m Hormonal therapy deregulates prostaglandin-endoperoxidase synthase 2 (PTGS2) expression in endometriotic tissues. therapeutic application,unassigned 1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24423359&form=6&db=m Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. therapeutic application,unassigned 1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24901401&form=6&db=m The expression of Cox-2, NF-?B, and VEGF in ectopic endometrial tissues within fallopian tubes suggests different etiologies. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24939730&form=6&db=m Menstrual blood-derived stromal stem cells from women with and without endometriosis reveal different phenotypic and functional characteristics. unassigned -
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25446850&form=6&db=m Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2? biosynthesis and action in ovarian endometriosis tissue and in model cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26054111&form=6&db=m Genetic variation in COX-2 -1195 and the risk of endometriosis and adenomyosis. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26153366&form=6&db=m Evaluation of the frequency of G-765C polymorphism in the promoter region of the COX-2 gene and its correlation with the expression of this gene in the endometrium of women with endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26276091&form=6&db=m COX-2 gene promoter DNA methylation status in eutopic and ectopic endometrium of Egyptian women with endometriosis. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26675577&form=6&db=m [Targeted interruption of COX-2 gene by siRNA inhibits the expression of VEGF, MMP-9, the activity of COX-2 and stimulates the apoptosis in eutopic, ectopic endometrial stromal cells of women with endometriosis]. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27038655&form=6&db=m Enhanced cyclooxygenase-2 expression levels and metalloproteinase 2 and 9 activation by Hexachlorobenzene in human endometrial stromal cells. unassigned -
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27132422&form=6&db=m -1195 A/G promoter variants of the cyclooxygenase-2 gene increases the risk of pain occurrence in endometriotic women. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27695098&form=6&db=m Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28281561&form=6&db=m EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis. ongoing research,unassigned 2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28548231&form=6&db=m Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28673205&form=6&db=m Nerve Growth Factor Is Associated With Sexual Pain in Women With Endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28734688&form=6&db=m PTGS2 down-regulation in cumulus cells of infertile women with endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28742579&form=6&db=m A Review of the Epigenetic Contributions to Endometriosis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402023&form=6&db=m 6-Shogaol reduces progression of experimental endometriosis in vivo and in vitro via regulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30644244&form=6&db=m Comparing The Effects of Glycyrrhiza glabra Root Extract, A Cyclooxygenase-2 Inhibitor (Celecoxib) and A Gonadotropin-Releasing Hormone Analog (Diphereline) in A Rat Model of Endometriosis. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30773096&form=6&db=m Lipoxin A4 Suppresses IL-1?-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31247078&form=6&db=m B lymphocytes inactivation by Ibrutinib limits endometriosis progression in mice. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31527378&form=6&db=m Suppressive Effects of Ursolic Acid on Human Endometriotic Stromal Cells Survival. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31714804&form=6&db=m Identification of differentially expressed proteins associated with recurrence in ovarian endometriotic cysts. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31853218&form=6&db=m Cyclooxygenase-2 in Endometriosis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32311852&form=6&db=m Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32685413&form=6&db=m The Anti-Inflammatory Effect of Octyl Gallate Through Inhibition of Nuclear Factor-?B (NF-?B) Pathway in Rat Endometriosis Model. unassigned -
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32892034&form=6&db=m The -1195A>G polymorphism in Ciclooxygenase-2 gene is associated with lower risk of endometriosis. diagnostic usage,unassigned 2,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751518&form=6&db=m Providing new insights into the endometriosisassociated cancer arising in episiotomy scars. causal interaction,unassigned 3,0
1.14.99.1 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34247812&form=6&db=m The pro-inflammatory and anti-inflammatory role of hyaluronic acid in endometriosis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12411038&form=6&db=m Cyclooxyenase-2 expression in endometrium carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19459433&form=6&db=m Expression of cyclooxygenase-2 in the inflammatory changed porcine uterus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21720106&form=6&db=m Expression of Cyclooxygenase-2 in the Endometrium of Gilts with Different Stages of Endometritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28244342&form=6&db=m Endometrial mRNA expression of prostaglandin synthase enzymes PTGS 2, PTGFS and mPTGES 1 in repeat-breeding cows with cytologically determined endometritis. unassigned -
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28822903&form=6&db=m Uterine clinical findings, fertility rate, leucocyte migration, and COX-2 protein levels in the endometrial tissue of susceptible mares treated with platelet-rich plasma before and after AI. therapeutic application,unassigned 4,0
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29104078&form=6&db=m Eucalyptus robusta leaves methanolic extract suppresses inflammatory mediators by specifically targeting TLR4/TLR9, MPO, COX2, iNOS and inflammatory cytokines in experimentally-induced endometritis in rats. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29215850&form=6&db=m [The role of prostaglandins and Cyclooxygenase in pathogenesis of chronic endometritis]. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31133302&form=6&db=m Evidence for Increased Content of PGF2?, PGE2, and 6-keto-PGF1? in Endometrial Tissue Cultures From Heavy Draft Mares in Anestrus With Endometritis. causal interaction,unassigned 1,0
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32734100&form=6&db=m Destination of corpus luteum in postpartum clinical endometritis cows and factors affecting self-recovery. ongoing research,unassigned 1,0
1.14.99.1 Endometritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32821660&form=6&db=m Endometritis in the bitch: Immunohistochemical localization of cyclooxygenase 2. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1511505&form=6&db=m Effect of ibuprofen upon denervated skeletal muscle resistance and compliance vessels during endotoxemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2846494&form=6&db=m Effect of inhibition of 5-lipoxygenase metabolism of arachidonic acid on response to endotoxemia in sheep. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080926&form=6&db=m Modulation of arachidonic acid metabolism in endotoxic horses: comparison of flunixin meglumine, phenylbutazone, and a selective thromboxane synthetase inhibitor. therapeutic application,unassigned 4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3085564&form=6&db=m Endotoxin and lung injury. causal interaction,unassigned 2,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3105370&form=6&db=m BW755C modifies endotoxin-induced respiratory failure in pigs. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3881286&form=6&db=m Metabolites of arachidonic acid in experimental lung vascular injury. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3881383&form=6&db=m Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs. causal interaction,unassigned 3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3905755&form=6&db=m Effects of flunixin meglumine on cardiopulmonary responses to endotoxin in ponies. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3919961&form=6&db=m Endotoxin-induced eicosanoid production by equine vascular endothelial cells and neutrophils. therapeutic application,unassigned 4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3921978&form=6&db=m Pulmonary dysfunction caused by diffuse lung inflammation. Roles of metabolites of arachidonic acid. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6409930&form=6&db=m Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep. unassigned -
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6808526&form=6&db=m Effects of cyclooxygenase inhibitors on pulmonary vascular responses to endotoxin in unanesthetized sheep. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6824037&form=6&db=m An assessment of the participatory role of prostaglandins and serotonin in the pathophysiology of endotoxic shock. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8481974&form=6&db=m Effectiveness of dual cyclooxygense and leukotriene blockade with ibuprofen and LY203647 during canine endotoxic shock. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9201060&form=6&db=m Effect of NG-nitro-L-arginine-methyl-ester on cardiopulmonary function and biosynthesis of cyclooxygenase products during porcine endotoxemia. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9207278&form=6&db=m Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9397995&form=6&db=m Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat. ongoing research,unassigned 1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9827537&form=6&db=m Oxidative injury and survival during endotoxemia. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9841832&form=6&db=m Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10211684&form=6&db=m Endotoxin induction of nitric oxide synthase and cyclooxygenase-2 in equine alveolar macrophages. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10359020&form=6&db=m Ibuprofen attenuates cardiopulmonary dysfunction by modifying vascular tone in endotoxemia. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10454835&form=6&db=m The role of cyclooxygenase in regulation of vasomotor tone during endotoxemia. ongoing research,unassigned 2,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10594073&form=6&db=m An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia. ongoing research,unassigned 1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10898721&form=6&db=m Antithrombin reduces leukocyte adhesion during chronic endotoxemia by modulation of the cyclooxygenase pathway. causal interaction,unassigned 3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11504678&form=6&db=m Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11520726&form=6&db=m Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11568518&form=6&db=m Age-dependent changes in the regulation of cyclooxygenases in the gastrointestinal tract after gram-negative endotoxemia. causal interaction,unassigned 4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11602676&form=6&db=m Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration. causal interaction,unassigned 1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11748396&form=6&db=m Brain expression of inducible cyclooxygenase 2 messenger RNA in rats undergoing cardiopulmonary bypass. causal interaction,unassigned 3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11763188&form=6&db=m Investigation of mRNA expression of tumor necrosis factor-alpha, interleukin-1beta, and cyclooxygenase-2 in cultured equine digital artery smooth muscle cells after exposure to endotoxin. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11880315&form=6&db=m Activation of type II alveolar epithelial cells during acute endotoxemia. ongoing research,unassigned 3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12050186&form=6&db=m Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738799&form=6&db=m Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12794420&form=6&db=m Microdialysis-evaluated myocardial cyclooxygenase-mediated inflammation and early circulatory depression in porcine endotoxemia. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14752832&form=6&db=m Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14988416&form=6&db=m In vivo study on cross talk between inducible nitric-oxide synthase and cyclooxygenase in rat gastric mucosa: effect of cyclooxygenase activity on nitric oxide production. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15181007&form=6&db=m Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218320&form=6&db=m Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15345145&form=6&db=m Alteration in heme oxygenase-1 and nitric oxide synthase-2 gene expression during endotoxemia in cyclooxygenase-2-deficient mice. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15591708&form=6&db=m Effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on cardiovascular alterations in endotoxemia. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16153419&form=6&db=m Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552365&form=6&db=m Inhibition of endothelin-1-mediated up-regulation of iNOS by bosentan ameliorates endotoxin-induced liver injury in cirrhosis. causal interaction,unassigned 3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16641887&form=6&db=m Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule. ongoing research,unassigned 2,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17614138&form=6&db=m The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17655858&form=6&db=m Phospholipase Cgamma1 signalling regulates lipopolysaccharide-induced cyclooxygenase-2 expression in cardiomyocytes. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18216604&form=6&db=m Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat. unassigned -
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18216606&form=6&db=m Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18946499&form=6&db=m COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex. therapeutic application,unassigned 1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21543636&form=6&db=m Disruption of COX-2 and eNOS does not confer protection from cardiovascular failure in lipopolysaccharide-treated conscious mice and isolated vascular rings. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21641970&form=6&db=m Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22155099&form=6&db=m Berberine ameliorates COX-2 expression in rat small intestinal mucosa partially through PPAR? pathway during acute endotoxemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931732&form=6&db=m ?-Solanine Isolated from Solanum tuberosum L. cv Jayoung Abrogates LPS-Induced Inflammatory Responses via NF-?B Inactivation in RAW 264.7 Macrophages and Endotoxin-Induced Shock Model in Mice. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26977531&form=6&db=m Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock. ongoing research,unassigned 3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27160391&form=6&db=m Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NFx03BA;B-Dependent Mechanism. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27530729&form=6&db=m Effect of pioglitazone on metabolic features in endotoxemia model in obese diabetic db/db mice. ongoing research,unassigned 1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28127806&form=6&db=m Ethanol Extract of Potentilla supina Linne Suppresses LPS-induced Inflammatory Responses through NF-?B and AP-1 Inactivation in Macrophages and in Endotoxic mice. ongoing research,unassigned 2,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30317130&form=6&db=m Changes in DNA integrity and gene expression in ovarian follicular cells of lipopolysaccharide-treated female mice. diagnostic usage,unassigned 1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31490357&form=6&db=m EP2 Receptor Blockade Attenuates COX-2 Upregulation During Intestinal Inflammation. causal interaction,unassigned 1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31683199&form=6&db=m A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32002856&form=6&db=m A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Endotoxemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32998462&form=6&db=m Novel Combination of COX-2 Inhibitor and Antioxidant Therapy for Modulating Oxidative Stress Associated with Intestinal Ischemic Reperfusion Injury and Endotoxemia. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Entamoebiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172219&form=6&db=m Entamoeba histolytica: induction of cyclooxygenase-2 expression during amoebic liver abscess formation in hamsters (Mesocricetus auratus). causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Enteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16780881&form=6&db=m Increased expression of cyclooxygenase-2 (COX-2) in radiation-induced small bowel injury in rats. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Enteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18685393&form=6&db=m Radiotherapy: long-term effects on gastrointestinal function. causal interaction,unassigned 3,0
1.14.99.1 Enteritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31601882&form=6&db=m Microbial metabolite deoxycholic acid controls Clostridium perfringens-induced chicken necrotic enteritis through attenuating inflammatory cyclooxygenase signaling. causal interaction,unassigned 2,0
1.14.99.1 Enterocolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22679002&form=6&db=m MyD88 signaling promotes both mucosal homeostatic and fibrotic responses during Salmonella-induced colitis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Enterocolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23525603&form=6&db=m Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism. causal interaction,unassigned 1,0
1.14.99.1 Enterocolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25365504&form=6&db=m Salmonella enterica serovar Enteritidis enterocolitis during late stages of gestation induces an adverse pregnancy outcome in the murine model. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202923&form=6&db=m The promise of prostaglandins: have they fulfilled their potential as therapeutic targets for the delay of preterm birth? causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17618875&form=6&db=m Molecular signaling in necrotizing enterocolitis: regulation of intestinal COX-2 expression. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20199731&form=6&db=m [Protective effects of curcumin on neonatal rats with necrotizing enterocolitis] ongoing research,unassigned 4,0
1.14.99.1 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852724&form=6&db=m Amniotic Fluid Stem Cells Prevent Development of Ascites in a Neonatal Rat Model of Necrotizing Enterocolitis. ongoing research,unassigned 1,0
1.14.99.1 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24210203&form=6&db=m Mucosal loss with increased expression of IL-6, IL-8, and COX-2 in a formula-feeding only neonatal rat model of necrotizing enterocolitis. unassigned -
1.14.99.1 Enterocolitis, Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34546832&form=6&db=m Low-dose cyclooxygenase-2 (COX-2) inhibitor celecoxib plays a protective role in the rat model of neonatal necrotizing enterocolitis. ongoing research,unassigned 4,0
1.14.99.1 Enzootic Bovine Leukosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10823885&form=6&db=m Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Enzootic Bovine Leukosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366713&form=6&db=m Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1422263&form=6&db=m Pharmacological modulation of the late eosinophilia induced by antigen in actively sensitized rats. therapeutic application,unassigned 4,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1659282&form=6&db=m Contribution of leukotriene B4 to airway inflammation and the effect of antagonists. therapeutic application,unassigned 2,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8588068&form=6&db=m Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8887574&form=6&db=m Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. unassigned -
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10623853&form=6&db=m Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. therapeutic application,unassigned 2,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10934105&form=6&db=m Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice. causal interaction,unassigned 2,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14564348&form=6&db=m Increased prostaglandin E2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophilia. causal interaction,unassigned 4,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150127&form=6&db=m Combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor (celecoxib) elicits antitumor immunity and long-term survival in CEA.Tg/MIN mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15611279&form=6&db=m Cyclooxygenase inhibition augments allergic inflammation through CD4-dependent, STAT6-independent mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762422&form=6&db=m Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. causal interaction,unassigned 3,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17512652&form=6&db=m Anthocyanins inhibit airway inflammation and hyperresponsiveness in a murine asthma model. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18411276&form=6&db=m Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. therapeutic application,unassigned 1,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085850&form=6&db=m Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28279492&form=6&db=m Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Eosinophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28919220&form=6&db=m Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro-inflammatory mediators. therapeutic application,unassigned 1,0
1.14.99.1 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254709&form=6&db=m Overexpression of cyclooxygenase-2 in childhood ependymomas: role of COX-2 inhibitor in growth and multi-drug resistance in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17007443&form=6&db=m Cyclooxygenase-2 (cox-2) expression and angiogenesis in intracranial ependymomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1
1.14.99.1 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17080719&form=6&db=m Expression of cyclo-oxygenase-2 in ependymal tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Ependymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355023&form=6&db=m Cyclooxygenase-2 expression in ependymoma of the spinal cord. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Epidermolysis Bullosa Dystrophica http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3018087&form=6&db=m ATP-induced cell contraction with epidermolysis bullosa dystrophica recessive and normal dermal fibroblasts. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3927864&form=6&db=m Differential effect of prostaglandin synthetase inhibitor pretreatment on pentylenetetrazol-induced seizures in rat. ongoing research,unassigned 3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10961765&form=6&db=m Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059791&form=6&db=m Neuroinflammatory signaling upregulation in Alzheimer's disease. therapeutic application,unassigned 1,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11251211&form=6&db=m Cyclooxygenase-2 expression in the hippocampus of genetically epilepsy susceptible El mice was increased after seizure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470703&form=6&db=m Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15571975&form=6&db=m Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16629370&form=6&db=m Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16671960&form=6&db=m Effect of rofecoxib, a cyclo-oxygenase-2 inhibitor, on various biochemical parameters of brain associated with pentylenetetrazol-induced chemical kindling in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806953&form=6&db=m Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16844276&form=6&db=m Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16981403&form=6&db=m Cyclooxygenase system contributes to the maintenance of post convulsive period of epileptic phenomena in the genetically epileptic El mice. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17604186&form=6&db=m Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. ongoing research,unassigned 4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18178179&form=6&db=m Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18195459&form=6&db=m Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations. causal interaction,unassigned 4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19186029&form=6&db=m Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19343233&form=6&db=m Cyclooxygenase in epilepsy: from perception to application. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19371577&form=6&db=m Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19890496&form=6&db=m Signaling to P-glycoprotein-A new therapeutic target to treat drug-resistant epilepsy? causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353773&form=6&db=m The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590600&form=6&db=m Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20643531&form=6&db=m Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20655707&form=6&db=m Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219314&form=6&db=m Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957234&form=6&db=m Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal cyclooxygenase-2 function, lipid peroxidation, and neuroprotection. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22444245&form=6&db=m Chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy. causal interaction,unassigned 1,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23030268&form=6&db=m A possible role of cyclooxygenase-2 in the relationship between sleep and sudden unexpected death in epilepsy. ongoing research,unassigned 3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24446952&form=6&db=m Cyclooxygenase-2 in epilepsy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24861495&form=6&db=m Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures. causal interaction,unassigned 4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25600211&form=6&db=m Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328537&form=6&db=m Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26961169&form=6&db=m Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. therapeutic application,unassigned 1,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27874832&form=6&db=m Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent. unassigned -
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895618&form=6&db=m Cyclooxygenase-1 as a Potential Therapeutic Target for Seizure Suppression: Evidences from Zebrafish Pentylenetetrazole-Seizure Model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28017780&form=6&db=m Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28038393&form=6&db=m Managing epilepsy-associated depression: Serotonin enhancers or serotonin producers? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28044053&form=6&db=m Plasma Levels of Cyclooxygenase-2 (COX-2) and Visfatin During Different Stages and Different Subtypes of Migraine Headaches. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28097203&form=6&db=m Staged anticonvulsant screening for chronic epilepsy. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212985&form=6&db=m Nonsteroidal anti-inflammatory drugs in clinical and experimental epilepsy. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28977690&form=6&db=m Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399113&form=6&db=m Geniposide attenuates epilepsy symptoms in a mouse model through the PI3K/Akt/GSK-3? signaling pathway. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29593494&form=6&db=m Antiepileptogenic Effect of Subchronic Palmitoylethanolamide Treatment in a Mouse Model of Acute Epilepsy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30030837&form=6&db=m The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue. causal interaction,unassigned 4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30521407&form=6&db=m An update of cyclooxygenase (COX)-inhibitors in epilepsy disorders. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30529453&form=6&db=m Temporal profile of serum mitochondrial DNA (mtDNA) in patients with aneurysmal subarachnoid hemorrhage (aSAH). therapeutic application,unassigned 1,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30794658&form=6&db=m Impact of a selective cyclooxygenase-2 inhibitor, celecoxib, on cortical excitability and electrophysiological properties of the brain in healthy volunteers: A randomized, double-blind, placebo-controlled study. therapeutic application,unassigned 4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31011358&form=6&db=m Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats. unassigned -
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666079&form=6&db=m Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31948324&form=6&db=m LncRNA NEAT1 affects inflammatory response by targeting miR-129-5p and regulating Notch signaling pathway in epilepsy. ongoing research,unassigned 1,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32054883&form=6&db=m Downregulation of peripheral PTGS2/COX-2 in response to valproate treatment in patients with epilepsy. causal interaction,unassigned 2,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32702600&form=6&db=m COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice. causal interaction,unassigned 4,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32789796&form=6&db=m Ibuprofen Exerts Antiepileptic and Neuroprotective Effects in the Rat Model of Pentylenetetrazol-Induced Epilepsy via the COX-2/NLRP3/IL-18 Pathway. causal interaction,unassigned 3,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34310255&form=6&db=m Understanding mechanisms of drug resistance in epilepsy and strategies for overcoming it. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Epilepsy, Absence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701797&form=6&db=m Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470703&form=6&db=m Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15571975&form=6&db=m Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19186029&form=6&db=m Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353773&form=6&db=m The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20590600&form=6&db=m Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20643531&form=6&db=m Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20655707&form=6&db=m Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Epilepsy, Temporal Lobe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22444245&form=6&db=m Chemotactic and mitogenic stimuli of neuronal apoptosis in patients with medically intractable temporal lobe epilepsy. causal interaction,unassigned 1,0
1.14.99.1 Epiretinal Membrane http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952655&form=6&db=m Expression of cyclo-oxygenase-2 and downstream enzymes in diabetic fibrovascular epiretinal membranes. ongoing research,unassigned 2,0
1.14.99.1 Epiretinal Membrane http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19996819&form=6&db=m CYCLO-OXYGENASE-2 EXPRESSION IN HUMAN IDIOPATHIC EPIRETINAL MEMBRANE. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Epistaxis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18690928&form=6&db=m The role of the New Zealand Intensive Medicines Monitoring Programme in identification of previously unrecognised signals of adverse drug reactions. therapeutic application,unassigned 1,0
1.14.99.1 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415009&form=6&db=m Epstein-Barr virus protein can upregulate cyclo-oxygenase-2 expression through association with the suppressor of metastasis Nm23-H1. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19118057&form=6&db=m Cyclooxygenase-2 is an independent prognostic factor in gastric carcinoma patients receiving adjuvant chemotherapy and is not associated with EBV infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24294363&form=6&db=m Epstein-Barr virus infection correlates with the expression of COX-2, p16(INK4A) and p53 in classic Hodgkin lymphoma. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Epstein-Barr Virus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26632465&form=6&db=m [Expression and prognostic value of COX- 2, p16(INK4A) and p53 in patients with classical Hodgkin lymphoma]. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16259716&form=6&db=m Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats. therapeutic application,unassigned 1,0
1.14.99.1 Erectile Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26876900&form=6&db=m New evidence from the Prostate Cancer Prevention Trial may exculpate cyclooxygenase (COX) blockers in erectile dysfunction. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=414528&form=6&db=m The effect of topically applied agents on ultraviolet erythema in guinea pigs. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2128168&form=6&db=m Anti-inflammatory pharmacology and mechanism of the orally active capsaicin analogs, NE-19550 and NE-28345. diagnostic usage,unassigned 3,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2478604&form=6&db=m The pattern and kinetics in human skin of erythema and mediators during the acute and late-phase response (LPR). causal interaction,unassigned 2,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3912734&form=6&db=m Eicosanoids in skin UV inflammation. ongoing research,unassigned 2,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6111891&form=6&db=m Inhibition of erythema induced by pro-inflammatory esters of 12-deoxyphorbol. therapeutic application,unassigned 2,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7454887&form=6&db=m The anti-inflammatory and pharmacological effects of topically applied flurbiprofen on human skin 24 hours after ultraviolet B irradiation. therapeutic application,unassigned 1,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7509761&form=6&db=m Nitric oxide and human skin blood flow responses to acetylcholine and ultraviolet light. unassigned -
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9626565&form=6&db=m Effects of several agents on UVB- and UVA plus systemic fluoroquinolone-induced erythema of guinea pig skin evaluated by reflectance colorimetry. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635856&form=6&db=m COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126310&form=6&db=m Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16279229&form=6&db=m [Cyclooxygenases in the skin] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16354205&form=6&db=m Selective cyclooxygenase-2 inhibition produces heterogeneous erythema response to ultraviolet irradiation. therapeutic application,unassigned 4,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17663920&form=6&db=m Safety of celecoxib in patients with cutaneous reactions due to ASA-NSAIDs intolerance. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17845216&form=6&db=m Increased cyclooxygenase expression and thymine dimer formation after repeated exposures of humans to low doses of solar simulated radiation. ongoing research,unassigned 3,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584301&form=6&db=m The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21281711&form=6&db=m UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo. ongoing research,unassigned 1,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21435898&form=6&db=m Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22173231&form=6&db=m The eicosanoid response to high dose UVR exposure of individuals prone and resistant to sunburn. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22761785&form=6&db=m Local gene expression changes after UV-irradiation of human skin. causal interaction,unassigned 1,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23291917&form=6&db=m Risk assessment of excess drug and sunscreen absorption via skin with ablative fractional laser resurfacing : Optimization of the applied dose for postoperative care. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28697472&form=6&db=m Protective effects of grape stem extract against UVB-induced damage in C57BL mice skin. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29458014&form=6&db=m Topical delivery of l-theanine ameliorates TPA-induced acute skin inflammation via downregulating endothelial PECAM-1 and neutrophil infiltration and activation. causal interaction,unassigned 1,0
1.14.99.1 Erythema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30308980&form=6&db=m Fucoxanthin-Containing Cream Prevents Epidermal Hyperplasia and UVB-Induced Skin Erythema in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Erythema Multiforme http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15926604&form=6&db=m COX-2 selective nonsteroidal anti-inflammatory drugs: current status. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Erythromelalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12781799&form=6&db=m Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts. unassigned -
1.14.99.1 Erythromelalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18475550&form=6&db=m Prostaglandin cyclooxygenase products but not thromboxane A(2) are involved in the pathogenesis of ewthromelalgia in thrombocythaemia. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Erythromelalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25116182&form=6&db=m Aspirin-responsive, migraine-like transient cerebral and ocular ischemic attacks and erythromelalgia in JAK2-positive essential thrombocythemia and polycythemia vera. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Erythromelalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27264763&form=6&db=m Aspirin Responsive Thrombotic Complications in Thrombocythemia Vera. A Novel Platelet-Mediated Arterial Thrombophilia. therapeutic application,unassigned 3,0
1.14.99.1 Escherichia coli Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27631977&form=6&db=m Cytosolic and Calcium-Independent Phospholipases A2 Activation and Prostaglandins E2 Are Associated with Escherichia coli-Induced Reduction of Insulin Secretion in INS-1E Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Escherichia coli Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32362888&form=6&db=m Cyclooxygenase-2 Inhibition Reduces Autophagy of Macrophages Enhancing Extraintestinal Pathogenic Escherichia coli Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892207&form=6&db=m Cyclooxygenase-2 expression in human esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11285187&form=6&db=m Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821953&form=6&db=m Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11922545&form=6&db=m NSAID inhibition of GI cancer growth: clinical implications and molecular mechanisms of action. causal interaction,unassigned 3,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11989839&form=6&db=m Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12659684&form=6&db=m Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12845669&form=6&db=m The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma. diagnostic usage,unassigned 2,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12893070&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in premalignant and malignant esophageal glandular and squamous lesions in Cixian, China. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552327&form=6&db=m COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633464&form=6&db=m [Cyclooxygenase-2 expression in esophageal cancer cells and induction by mitomycin C] causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14765307&form=6&db=m Gastroesophageal reflux disease and Barrett's esophagus. unassigned -
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15013721&form=6&db=m COX-2: a target for prevention and treatment of esophageal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145696&form=6&db=m Antiproliferative and apoptotic effects of rofecoxib on esophageal cancer in vitro(1). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151617&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15173710&form=6&db=m Prognostic significance of vascular endothelial growth factor and cyclooxygenase 2 expression in patients receiving preoperative chemoradiation for esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15259059&form=6&db=m Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476151&form=6&db=m Effect of chronic intake of NSAIDs and cyclooxygenase 2-selective inhibitors on esophageal cancer incidence. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685829&form=6&db=m Cisplatin, fluorouracil, celecoxib, and RT in resectable esophageal cancer: preliminary results. diagnostic usage,unassigned 3,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15978332&form=6&db=m Prognostic role of cyclooxygenase-2 expression in esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083713&form=6&db=m Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170369&form=6&db=m Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16220041&form=6&db=m Cyclooxygenase-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299228&form=6&db=m Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322294&form=6&db=m High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16327494&form=6&db=m Neoadjuvant selective COX-2 inhibition down-regulates important oncogenic pathways in patients with esophageal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16557574&form=6&db=m Chenodeoxycholic acid stimulates the progression of human esophageal cancer cells: A possible mechanism of angiogenesis in patients with esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16682957&form=6&db=m Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16938519&form=6&db=m The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17511025&form=6&db=m Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17650224&form=6&db=m Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058818&form=6&db=m The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18443952&form=6&db=m Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632220&form=6&db=m COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19160097&form=6&db=m NS-398 induces apoptosis in human esophageal cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258542&form=6&db=m Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19534809&form=6&db=m Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633925&form=6&db=m Effects of the Inhibition of Cyclooxygenase-2 on Human Esophageal Cancer Cells: Inhibition of Cell Proliferation and Induction of Apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19679052&form=6&db=m Immunohistochemical analysis of selected molecular markers in esophagus precancerous, adenocarcinoma and squamous cell carcinoma in Iranian subjects. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19954064&form=6&db=m [Genetic polymorphisms in STK15 and MMP-2 associated susceptibility to esophageal cancer in Mongolian population] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20486853&form=6&db=m Cyclooxygenase-2 inhibitor NS398 enhances radiosensitivity of radioresistant esophageal cancer cells by inhibiting AKT activation and inducing apoptosis. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878581&form=6&db=m [Correlation of cyclooxygenase 2 expression with microlymphatic density and its clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21087344&form=6&db=m The radiosensitization effect of NS398 on esophageal cancer stem cell-like radioresistant cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21177414&form=6&db=m Celecoxib antagonizes the cytotoxicity of cisplatin in human esophageal squamous cell carcinoma cells by reducing intracellular cisplatin accumulation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21304218&form=6&db=m Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21329005&form=6&db=m A cyclooxygase-2 inhibitor NS-398-enhanced apoptosis of esophageal carcinoma cell EC9706 by adjusting expression of survivin and caspase-3. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443112&form=6&db=m Expression characteristics of heparanase in colon carcinoma and its close relationship with cyclooxygenase-2 and angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22944132&form=6&db=m [Small interfering RNA in silencing cox-2 expression enhances radiosensitivity of esophageal cancer EC9706 cell]. ongoing research,unassigned 4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24212953&form=6&db=m Inflammation-related carcinogenesis and prevention in esophageal adenocarcinoma using rat duodenoesophageal reflux models. therapeutic application,unassigned 4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24284961&form=6&db=m Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24641411&form=6&db=m Association of Single Nucleotide Polymorphisms in the Prostaglandin-endoperoxide Synthase 2 (PTGS2) and Phospholipase A2 Group IIA (PLA2G2A) Genes with Susceptibility to Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24999355&form=6&db=m Amiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts. unassigned -
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25266020&form=6&db=m Strategy for prevention of cancers of the esophagus. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25370734&form=6&db=m The close correlation between heparanase and COX-2 expression in lymphangiogenesis of cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875558&form=6&db=m Coexpression of COX-2 and iNOS in Angiogenesis of Superficial Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26147856&form=6&db=m Rhizoma Paridis Saponins Suppresses Tumor Growth in a Rat Model of N-Nitrosomethylbenzylamine-Induced Esophageal Cancer by Inhibiting Cyclooxygenases-2 Pathway. causal interaction,unassigned 1,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26474693&form=6&db=m Celecoxib antagonizes the cytotoxicity of oxaliplatin in human esophageal cancer cells by impairing the drug influx. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622818&form=6&db=m Analysis of the correlation between P53 and Cox-2 expression and prognosis in esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27412386&form=6&db=m Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28652771&form=6&db=m The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29893307&form=6&db=m Evaluating the expression of cyclooxygenase-2 enzyme by immunohistochemistry in normal and tumoral tissue before and after neoadjuvant chemoradiotherapy in patients with esophageal cancer in Khorasan Province. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32235869&form=6&db=m New insights into the functions of Cox-2 in skin and esophageal malignancies. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11810043&form=6&db=m Expression of cyclooxygenase-2 is associated with carcinogenesis of the lower part of thoracic esophageal squamous cell carcinoma and p53 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11989839&form=6&db=m Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963227&form=6&db=m Clinicopathologic significance of cyclooxygenase-2 overexpression in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14989896&form=6&db=m [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151619&form=6&db=m Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15259059&form=6&db=m Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15354416&form=6&db=m A selective cyclooxygenase-2 inhibitor, NS398, inhibits cell growth and induces cell cycle arrest in the G2/M phase in human esophageal squamous cell carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358635&form=6&db=m Expression of macrophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of bile acids and NSAIDs. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701502&form=6&db=m Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756444&form=6&db=m Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856454&form=6&db=m Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083713&form=6&db=m Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202995&form=6&db=m Cyclooxygenase-2 is over-expressed in Chinese esophageal squamous cell carcinoma, and correlated with NF-kappaB: an immunohistochemical study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352617&form=6&db=m Significance of COX-2 expression in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17142201&form=6&db=m Prognostic factors and COX-2 expression in advanced stage esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220580&form=6&db=m Cyclo-oxygenase-2 over-expression is associated with human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17460548&form=6&db=m Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17553653&form=6&db=m Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17591056&form=6&db=m Clinicopathologic significance of expression of cyclooxygenase-2 in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17672932&form=6&db=m [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18197933&form=6&db=m COX-2 mRNA expression in esophageal squamous cell carcinoma (ESCC) and effect by NSAID. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18459994&form=6&db=m Overexpression of cyclooxygenase-2 is associated with chemoradiotherapy resistance and prognosis in esophageal squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18564172&form=6&db=m Effects of cyclooxygenase-2 non-selective and selective inhibitors on proliferation inhibition and apoptosis induction of esophageal squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18583546&form=6&db=m E series of prostaglandin receptor 2-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632220&form=6&db=m COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18717758&form=6&db=m Early upregulation of cyclooxygenase-2 in human papillomavirus type 16 and telomerase-induced immortalization of human esophageal epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19082515&form=6&db=m The inhibitory effect of Gleditsia sinensis on cyclooxygenase-2 expression in human esophageal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148359&form=6&db=m [p53, p16 E COX-2 expression in esophageal squamous cell carcinoma and histopathological association] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428370&form=6&db=m Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19463183&form=6&db=m Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19549265&form=6&db=m Meta-analysis: clinicopathological and prognostic significance of cyclooxygenase-2 expression on oesophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19623651&form=6&db=m Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. causal interaction,unassigned 3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633925&form=6&db=m Effects of the Inhibition of Cyclooxygenase-2 on Human Esophageal Cancer Cells: Inhibition of Cell Proliferation and Induction of Apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19730383&form=6&db=m The relationship between HPV16 and expression of cyclooxygenase-2, P53 and their prognostic roles in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19816074&form=6&db=m The relationship between cyclooxygenase-2, CD44v6, and nm23H1 in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19999807&form=6&db=m [Cyclooxygenase inhibitors in chemoprevention and treatment of esophageal squamous cell carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878581&form=6&db=m [Correlation of cyclooxygenase 2 expression with microlymphatic density and its clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21157974&form=6&db=m Relationship between COX-2 and cell cycle-regulatory proteins in patients with esophageal squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21166741&form=6&db=m Promoter hypermethylation of cyclooxygenase-2 gene in esophageal squamous cell carcinoma. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468258&form=6&db=m VEGF as a Predictor for Response to Definitive Chemoradiotherapy and COX-2 as a Prognosticator for Survival in Esophageal Squamous Cell Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21652147&form=6&db=m Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21762277&form=6&db=m Clinicopathological significance of cyclooxygenase-2 and cell cycle-regulatory proteins expression in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21868314&form=6&db=m [Epidermal growth factor stimulates the proliferation of human esophageal squamous cell carcinoma HKESC-1 cells by increasing COX-2 expression]. ongoing research,unassigned 2,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22147962&form=6&db=m Effects of cyclooxygenase-2 on human esophageal squamous cell carcinoma. ongoing research,unassigned 4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435505&form=6&db=m Promoter methylation regulates cigarette smoke-stimulated cyclooxygenase-2 expression in esophageal squamous cell carcinoma. causal interaction,unassigned 1,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23177619&form=6&db=m Correlation analysis of c-myc, p21(WAF/CIP1), p53, C-erbB-2 and COX-2 proteins in esophageal squamous cell carcinoma. therapeutic application,unassigned 1,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23393346&form=6&db=m COX-2 overexpression Induced by gene transfer reduces sensitivity of TE13 esophageal carcinoma cells to 5-fluorouracil and cisplatin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426606&form=6&db=m Correlation among 16 biological factors [p53, p21(waf1), MIB-1 (Ki-67), p16(INK4A), cyclin D1, E-cadherin, Bcl-2, TNF-?, NF-?B, TGF-?, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1?] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,4
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24284961&form=6&db=m Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535229&form=6&db=m A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24641411&form=6&db=m Association of Single Nucleotide Polymorphisms in the Prostaglandin-endoperoxide Synthase 2 (PTGS2) and Phospholipase A2 Group IIA (PLA2G2A) Genes with Susceptibility to Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25172294&form=6&db=m Oesophageal squamous cell carcinoma in high-risk Chinese populations: Possible role for vascular epithelial growth factor A. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25395947&form=6&db=m Increased level of serum prostaglandin-2 in early stage of esophageal squamous cell carcinoma. causal interaction,unassigned 3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25405520&form=6&db=m JAK2 inhibitor blocks the inflammation and growth of esophageal squamous cell carcinoma in vitro through the JAK/STAT3 pathway. causal interaction,unassigned 1,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422234&form=6&db=m Overexpression of phospholipase A2 Group IIA in esophageal squamous cell carcinoma and association with cyclooxygenase-2 expression. unassigned -
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875558&form=6&db=m Coexpression of COX-2 and iNOS in Angiogenesis of Superficial Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26323923&form=6&db=m Expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in Chinese patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26556718&form=6&db=m Cyclooxygenase-2, a Potential Therapeutic Target, Is Regulated by miR-101 in Esophageal Squamous Cell Carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959737&form=6&db=m MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27148416&form=6&db=m High expression of cyclooxygenase 2 is an indicator of prognosis for patients with esophageal squamous cell carcinoma after Ivor Lewis esophagectomy. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27456944&form=6&db=m Anti-Cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma (ESCC) through Down-Regulation of COX-2 mRNA and PGE2. ongoing research,unassigned 4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27868288&form=6&db=m P21, COX-2, and E-cadherin are potential prognostic factors for esophageal squamous cell carcinoma. diagnostic usage,unassigned 4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454432&form=6&db=m Prognostic and predictive role of COX-2, XRCC1 and RASSF1 expression in patients with esophageal squamous cell carcinoma receiving radiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28553369&form=6&db=m Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29373910&form=6&db=m Expression of VEGF and Cox-2 in Patients with Esophageal Squamous Cell Carcinoma diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30339710&form=6&db=m Expression analysis of cyclooxygenase-2 in patients suffering from esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441691&form=6&db=m Lipid droplet biogenesis and COX-2 pathway activation are triggered by Barrett's esophagus and adenocarcinoma, but not esophageal squamous cell carcinoma risk factors. unassigned -
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2292356&form=6&db=m Protection by indomethacin against acute radiation esophagitis. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6821358&form=6&db=m [Evaluation of the activity of prostaglandin synthetase in biopsies of the cardio-esophageal region. Relation between sliding hiatal hernia and reflux esophagitis] diagnostic usage,unassigned 1,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7249895&form=6&db=m Beneficial effect of indomethacin on acid-induced esophagitis in cats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729118&form=6&db=m Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12772774&form=6&db=m Selective COX-2 inhibition is associated with decreased mucosal damage induced by acid and pepsin in rabbit esophagitis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811211&form=6&db=m Celecoxib associated esophagitis: review of gastrointestinal side effects from cox-2 inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552327&form=6&db=m COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15249402&form=6&db=m Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16172547&form=6&db=m Biphasic effect of prostaglandin E2 in a rat model of esophagitis mediated by EP1 receptors: relation to pepsin secretion. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16863546&form=6&db=m Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagus. causal interaction,unassigned 3,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17486744&form=6&db=m [Chemoprevention in adenocarcinoma of the esophagus] unassigned -
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17763959&form=6&db=m Effect of adiponectin and ghrelin on apoptosis of Barrett adenocarcinoma cell line. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20811626&form=6&db=m Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20814068&form=6&db=m Cyclooxygenase-2 (COX-2) is the key event in pathophysiology of Barrett's esophagus. Lesson from experimental animal model and human subjects. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21451212&form=6&db=m Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23440684&form=6&db=m Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells. ongoing research,unassigned 2,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24672789&form=6&db=m Animal model of Acid-reflux esophagitis: pathogenic roles of acid/pepsin, prostaglandins, and amino acids. causal interaction,unassigned 2,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26914122&form=6&db=m Anti-reflux anastomosis following esophagectomy for adenocarcinoma of the esophagogastric junction: impact of duodenogastroesophageal reflux and expression of cyclooxygenase-2 in the remnant esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056333&form=6&db=m [Recommendation for the prevention and treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal ulcers and its complications]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Esophagitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31928220&form=6&db=m Interaction of epidermal growth factor with COX-2 products and peroxisome proliferator-activated receptor-? system in experimental rat Barrett's esophagus. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6821358&form=6&db=m [Evaluation of the activity of prostaglandin synthetase in biopsies of the cardio-esophageal region. Relation between sliding hiatal hernia and reflux esophagitis] diagnostic usage,unassigned 1,0
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15807268&form=6&db=m [The clinical, pathological features and expression of Ki-67 and COX-2 in severe reflux esophagitis and Barrett's esophagus] diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16817839&form=6&db=m Prevention of NSAID-associated gastrointestinal lesions: a comparison study pantoprazole versus omeprazole. unassigned -
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17419241&form=6&db=m Comprehensive investigations of quality of life after esophagectomy with special reference to the route of reconstruction. diagnostic usage,unassigned 4,0
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581270&form=6&db=m COX-2 CA-Haplotype Is a Risk Factor for the Development of Esophageal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18349295&form=6&db=m Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Gene Polymorphisms and Risk of Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19120900&form=6&db=m What is the clinical significance of stromal angiogenesis in Barrett's esophagus? causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19207551&form=6&db=m Is the etiology of eosinophilic esophagitis in adults a response to allergy or reflux injury? Study of cellular proliferation markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21451212&form=6&db=m Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22210040&form=6&db=m Acid-induced COX-2 expression and prostaglandin E2 production via activation of ERK1/2 and p38 MAPK in cultured feline esophageal smooth muscle cells. causal interaction,unassigned 3,0
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22344232&form=6&db=m Molecular Pathways: Pathogenesis and clinical implications of microbiome alteration in esophagitis and Barrett's esophagus. unassigned -
1.14.99.1 Esophagitis, Peptic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26914122&form=6&db=m Anti-reflux anastomosis following esophagectomy for adenocarcinoma of the esophagogastric junction: impact of duodenogastroesophageal reflux and expression of cyclooxygenase-2 in the remnant esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1105697&form=6&db=m Antagonism of the effects of furosemide by indomethacin in normal and hypertensive man. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2827471&form=6&db=m Antihypertensive effect of enalapril in essential hypertension: role of prostacyclin. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6432714&form=6&db=m Reduction of the antihypertensive effect of captopril induced by prostaglandin synthetase inhibition. ongoing research,unassigned 3,0
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7048332&form=6&db=m Renal prostaglandins in borderline and sustained essential hypertension. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8500867&form=6&db=m Enhanced blood pressure response to cyclooxygenase inhibition in salt-sensitive human essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9039114&form=6&db=m Cyclooxygenase inhibition restores nitric oxide activity in essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9631871&form=6&db=m Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12923398&form=6&db=m Selective cyclo-oxygenase-2 inhibition with parecoxib acutely impairs endothelium-dependent vasodilatation in patients with essential hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,2
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23918748&form=6&db=m Endothelial nitric oxide synthase, cyclooxygenase-2, and essential hypertension: is there an interaction? causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Essential Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24156101&form=6&db=m Response to Endothelial nitric oxide synthase, cyclooxygenase-2, and essential hypertension: is there an interaction? causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Exanthema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3962783&form=6&db=m Dermatosis in magnesium-deficient hairless rats: effects of steroidal and non-steroidal anti-inflammatory drugs. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Exanthema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18064474&form=6&db=m A COX-2 inhibitor combined with chemoradiation of locally advanced rectal cancer: a phase II trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4
1.14.99.1 Exanthema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047118&form=6&db=m Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Exfoliation Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28085506&form=6&db=m Immunohistochemical Profiles of LOXL-1, FBN1, TGF-?1, and COX-2 in Pseudoexfoliation Syndrome. ongoing research,unassigned 1,0
1.14.99.1 Extranodal Extension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19340516&form=6&db=m Neoplasms escape selective COX-2 inhibition in an animal model of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9303324&form=6&db=m New aspects of mast cell biology. ongoing research,unassigned 4,0
1.14.99.1 Eye Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15017024&form=6&db=m Cyclooxygenase-2 expression in the cornea of dogs with keratitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Fabry Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19202000&form=6&db=m Differential involvement of COX1 and COX2 in the vasculopathy associated with the {alpha}-galactosidase A-knockout mouse. unassigned -
1.14.99.1 Facial Paralysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595974&form=6&db=m Activation of NF-?B signaling pathway in HSV-1-induced mouse facial palsy: Possible relation to therapeutic effect of glucocorticoids. causal interaction,unassigned 1,0
1.14.99.1 Familial Mediterranean Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912780&form=6&db=m Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Familial Primary Pulmonary Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1285867&form=6&db=m The use of low dose aspirin in pregnancy. causal interaction,unassigned 4,0
1.14.99.1 Fasciitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25214858&form=6&db=m Expression of HuR and Cyclooxygenase-2 in Nodular Fasciitis and Low-Grade Sarcoma: An Immunohistochemical Study. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6437143&form=6&db=m Dietary arachidonic acid protects mice against the fatty liver induced by a high fat diet and by ethanol. unassigned -
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388178&form=6&db=m Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. unassigned -
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15582125&form=6&db=m Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. therapeutic application,unassigned 1,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16557554&form=6&db=m COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835711&form=6&db=m Chronic effects of celecoxib, a cyclooxygenase-2 inhibitor, cause enhanced alcohol-induced liver steatosis in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16863510&form=6&db=m Chemoprevention of spontaneous development of hepatocellular carcinomas in fatty liver Shionogi mice by a cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594812&form=6&db=m [An experimental study on the reverse mechanism of PPAR-gamma agonist rosiglitazone in rats with non-alcoholic steatohepatitis] diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868330&form=6&db=m Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. unassigned -
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18049160&form=6&db=m Response to antiviral therapy and hepatic expression of cyclooxygenases in chronic hepatitis C. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18434432&form=6&db=m Thyroid hormone (T3) and TRbeta agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats. therapeutic application,unassigned 1,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19247274&form=6&db=m COX-2-mediated Inflammation in Fat Is Crucial for Obesity-linked Insulin Resistance and Fatty Liver. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19609863&form=6&db=m Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD). diagnostic usage,unassigned 4,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21433038&form=6&db=m Cyclooxygenase inhibition upregulates liver carnitine palmitoyltransferase 1A (CPT1A) expression and improves fatty liver. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21519329&form=6&db=m Oncostatin M produced in Kupffer cells in response to PGE2: possible contributor to hepatic insulin resistance and steatosis. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21643627&form=6&db=m Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. causal interaction,unassigned 3,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22676331&form=6&db=m Thromboxane Inhibitors Attenuate Inflammatory and Fibrotic Changes in Rat Liver Despite Continued Ethanol Administrations. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24372551&form=6&db=m Constitutive activation of AMPK ?1 in vascular endothelium promotes high-fat diet-induced fatty liver injury: role of COX-2 induction. causal interaction,unassigned 3,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26723251&form=6&db=m Suppressing Cyclooxygenase-2 Prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27227672&form=6&db=m Contribution of Cyclooxygenase End Products and Oxidative Stress to Intrahepatic Endothelial Dysfunction in Early Non-Alcoholic Fatty Liver Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27321932&form=6&db=m Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28871698&form=6&db=m [Effect of total flavones of hawthorn leafonon expression of COX-2/Nrf2 in liver of rats with nonalcoholic steatohepatitis]. diagnostic usage,unassigned 1,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31247902&form=6&db=m The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31342715&form=6&db=m [Effects of ellagic acid on inflammation and oxidative stress induced by AKT gene transfection in mice with fatty liver disease]. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32184095&form=6&db=m COX-2 in liver fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Fetal Death http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7860753&form=6&db=m Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Fetal Death http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10759148&form=6&db=m Genetic analysis of fetal development and parturition control in the mouse. causal interaction,unassigned 4,0
1.14.99.1 Fetal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2609339&form=6&db=m Effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on phenytoin-induced embryopathy in mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Fetal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8996197&form=6&db=m UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin. unassigned -
1.14.99.1 Fetal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10102698&form=6&db=m Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment. diagnostic usage,unassigned 3,0
1.14.99.1 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477204&form=6&db=m Thromboxane A(2) limits differentiation and enhances apoptosis of cultured human trophoblasts. causal interaction,unassigned 4,0
1.14.99.1 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17992008&form=6&db=m Cyclooxygenase inhibitors affect bone mineralization in rat fetuses. therapeutic application,unassigned 4,0
1.14.99.1 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19379806&form=6&db=m Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22814005&form=6&db=m Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22891569&form=6&db=m [Developmental toxicity of the over-the-counter analgetics and antypiretics]. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Fetal Growth Retardation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29521599&form=6&db=m Celecoxib restores angiogenic factor expression at the maternal-fetal interface in the BPH/5 mouse model of preeclampsia. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Fibroadenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895350&form=6&db=m [Expression of the cyclooxygenase-2 gene in human breast carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Fibroadenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926055&form=6&db=m Expression of cyclooxygenase-2 in malignant and benign breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Fibroadenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605950&form=6&db=m Expression of cyclooxygenase-1 and -2 in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Fibroadenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14659355&form=6&db=m Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Fibroadenoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21678409&form=6&db=m Interplay between membrane lipid peroxidation, transglutaminase activity and cyclooxygenase 2 expression in the tissue adjoining to breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Fibroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19594492&form=6&db=m Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Fibroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28851389&form=6&db=m Immunohistochemical staining with non-phospho ?-catenin as a diagnostic and prognostic tool of COX-2 inhibitor therapy for patients with extra-peritoneal desmoid-type fibromatosis. diagnostic usage,therapeutic application,unassigned 4,4,0
1.14.99.1 Fibroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692057&form=6&db=m Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313976&form=6&db=m Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16729958&form=6&db=m A comparison of methods for the analysis of low abundance proteins in desmoid tumor cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785554&form=6&db=m Cyclooxygenase-2 and platelet-derived growth factor receptors as potential targets in treating aggressive fibromatosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026797&form=6&db=m Successful treatment with meloxicam, a cyclooxygenase-2 inhibitor, of patients with extra-abdominal desmoid tumors: a pilot study. therapeutic application,unassigned 4,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24390670&form=6&db=m Nuclear expression of ?-catenin predicts the efficacy of meloxicam treatment for patients with sporadic desmoid tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24443892&form=6&db=m Desmoid tumor-associated pain is dependent on mast cell expression of cyclooxygenase-2. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24788118&form=6&db=m CTNNB1 S45F mutation predicts poor efficacy of meloxicam treatment for desmoid tumors: a pilot study. therapeutic application,unassigned 4,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25899770&form=6&db=m Low-dose chemotherapy with methotrexate and vinblastine for patients with desmoid tumors: relationship to CTNNB1 mutation status. therapeutic application,unassigned 3,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27450394&form=6&db=m Complete remission of pancreatic head desmoid tumor treated by COX-2 inhibitor-a case report. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29854347&form=6&db=m Role of Nonsteroidal Anti-inflammatory Drug in Treatment of Extra-abdominal Desmoid Tumors. therapeutic application,unassigned 4,0
1.14.99.1 Fibromatosis, Aggressive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30527567&form=6&db=m Successful treatment of a recurrent chest wall desmoid tumor with cyclooxygenase-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3462058&form=6&db=m Modulation of tumor cell motility by prostaglandins and inhibitors of prostaglandin synthesis. unassigned -
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6439740&form=6&db=m Dietary menhaden oil lowers plasma prostaglandins and calcium in mice bearing the prostaglandin-producing HSDM1 fibrosarcoma. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8900440&form=6&db=m Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9223587&form=6&db=m Induction of prostaglandin endoperoxide synthase-2 by serine-threonine phosphatase inhibition. ongoing research,unassigned 3,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9576062&form=6&db=m Tumour necrosis factor-alpha-dependent regulation of prostaglandin endoperoxide synthase-2. ongoing research,unassigned 3,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9580637&form=6&db=m Tyrosine phosphatase-dependent/tyrosine kinase-independent induction of nuclear factor-kappa B by tumor necrosis factor-alpha: effects on prostaglandin endoperoxide synthase-2 mRNA accumulation. ongoing research,unassigned 3,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12094544&form=6&db=m The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124326&form=6&db=m Cyclooxygenase-2 inhibitor treatment enhances photodynamic therapy-mediated tumor response. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12937850&form=6&db=m Administration of liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) and diclofenac in the combination attenuates their anti-tumor activities. ongoing research,unassigned 3,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18282182&form=6&db=m Cyclooxygenase-2 expression induced by photofrin photodynamic therapy involves the p38 MAPK pathway. ongoing research,unassigned 4,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18782185&form=6&db=m DTD, an anti-inflammatory ditriazine, inhibits angiogenesis in vitro and in vivo. therapeutic application,unassigned 1,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21071999&form=6&db=m Pifithrin-?, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26238650&form=6&db=m DNA-hypomethylating agent, 5'-azacytidine, induces cyclooxygenase-2 expression via the PI3-kinase/Akt and extracellular signal-regulated kinase-1/2 pathways in human HT1080 fibrosarcoma cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28634425&form=6&db=m A Transcriptional Regulatory Role for the Membrane Type-1 Matrix Metalloproteinase in Carcinogen-Induced Inflammasome Gene Expression. ongoing research,unassigned 3,0
1.14.99.1 Fibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30692057&form=6&db=m Comparison of fatty acid synthase and cyclooxygenase-2 immunoexpression in embryonal, benign, and malignant odontogenic tissues. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Follicular Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30271715&form=6&db=m Licorice ethanol extract improves symptoms of polycytic ovary syndrome in Letrozole-induced female rats. diagnostic usage,unassigned 4,0
1.14.99.1 Folliculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20726893&form=6&db=m Induction of inflammatory reactions by lipopolysaccharide in hamster sebaceous glands and pilosebaceous units in vivo and in vitro. causal interaction,unassigned 3,0
1.14.99.1 Foot Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27030654&form=6&db=m [Effects of San-huang-sheng-fu oil on peripheral circulatory disorders and foot ulcers in diabetic rats and the mechanisms]. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Friedreich Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25104852&form=6&db=m Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. causal interaction,unassigned 4,0
1.14.99.1 Gallbladder Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2666254&form=6&db=m Arachidonic acid metabolites in hepatobiliary physiology and disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gallbladder Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3896701&form=6&db=m Effect of oral ibuprofen on formation of prostaglandins E and F by human gallbladder muscle and mucosa. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Gallbladder Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10328326&form=6&db=m Synthetic pathways of gallbladder mucosal prostanoids: the role of cyclooxygenase-1 and 2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10328326&form=6&db=m Synthetic pathways of gallbladder mucosal prostanoids: the role of cyclooxygenase-1 and 2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874020&form=6&db=m The role of cyclooxygenase enzymes in the growth of human gall bladder cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15855925&form=6&db=m Oncolytic adenoviral therapy in gallbladder carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944215&form=6&db=m Inhibitory effect of meloxicam, a cyclooxygenase-2 inhibitor, on N-nitrosobis (2-oxopropyl) amine induced biliary carcinogenesis in Syrian hamsters. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17575102&form=6&db=m Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455278&form=6&db=m Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956499&form=6&db=m Co-Expression of Cox-2, C-Met and beta-catenin in Cells Forming Invasive front of Gallbladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22411700&form=6&db=m Role of ErbB2 mediated AKT and MAPK pathway in gall bladder cell proliferation induced by argemone oil and butter yellow : Argemone oil and butter yellow induced gall bladder cell proliferation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gallbladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26456195&form=6&db=m Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2666254&form=6&db=m Arachidonic acid metabolites in hepatobiliary physiology and disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8312687&form=6&db=m Indomethacin decreases viscosity of gallbladder bile in patients with cholesterol gallstone disease. therapeutic application,unassigned 4,0
1.14.99.1 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14636470&form=6&db=m [The impact of selective cycloxygenase-2 inhibitor celexibo on the formation of cholesterol gallstone] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16361272&form=6&db=m Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455278&form=6&db=m Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Gallstones http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26456195&form=6&db=m Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Ganglion Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19690271&form=6&db=m The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Ganglion Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29292676&form=6&db=m Neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) against peripheral nerve transection-induced apoptosis. ongoing research,unassigned 2,0
1.14.99.1 Gastric Outlet Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12395741&form=6&db=m [Anti-inflammatory non-steroidal selective cyclooxygenase 2 inhibitors and gastroduodenal lesions] causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Gastrinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12636104&form=6&db=m An immunohistochemical study of cyclooxygenase (COX)-2 expression in endocrine tumors of the pancreas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2786181&form=6&db=m Asymptomatic and symptomatic gastroduodenal patients affected by rheumatic disease treated with non-steroidal anti-inflammatory drugs. causal interaction,unassigned 4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10235197&form=6&db=m Cyclooxygenase-2 expression in gastric antral mucosa before and after eradication of Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10348815&form=6&db=m Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10533511&form=6&db=m When to try COX-2-specific inhibitors. Safer than standard NSAIDs in some situations. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10566756&form=6&db=m Increased COX-2, but not COX-1, mRNA expression in Helicobacter pylori gastritis. causal interaction,unassigned 2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807888&form=6&db=m Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980112&form=6&db=m Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesions. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005767&form=6&db=m Role of cyclooxygenase-2 in Helicobacter pylori- induced gastritis in Mongolian gerbils. causal interaction,unassigned 2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11040354&form=6&db=m Nonsteroidal anti-inflammatory drug-induced acute gastric injury in Helicobacter pylori gastritis in Mongolian gerbils. causal interaction,unassigned 3,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11076873&form=6&db=m Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa. causal interaction,unassigned 2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093953&form=6&db=m Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11148436&form=6&db=m Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11193491&form=6&db=m [Cyclooxygenase activity in chronic gastritis] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11289104&form=6&db=m Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11380326&form=6&db=m Involvement of cyclooxygenase-2 in hyperplastic gastritis induced by Helicobacter pylori infection in C57BL/6 mice. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11424315&form=6&db=m Effects of cyclooxygenase-2 inhibitor on gastric acid secretion in Helicobacter pylori-infected C57BL/6 mice. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11886470&form=6&db=m Effects of selective cyclooxygenase-2 inhibitor and non-selective NSAIDs on Helicobacter pylori-induced gastritis in Mongolian gerbils. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086403&form=6&db=m In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12625369&form=6&db=m Suppression of gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide by peroxisome proliferator-activated receptor gamma activation. ongoing research,unassigned 4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12823157&form=6&db=m Effect of cyclooxygenase-2 inhibition on human Helicobacter pylori gastritis: mechanisms underlying gastrointestinal safety and implications for cancer chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12912855&form=6&db=m Monocyte chemoattractant protein 1 (MCP-1) released from Helicobacter pylori stimulated gastric epithelial cells induces cyclooxygenase 2 expression and activation in T cells. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958020&form=6&db=m Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529402&form=6&db=m COX-2 inhibition, H. pylori infection and the risk of gastrointestinal complications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530307&form=6&db=m Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. causal interaction,unassigned 4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14627349&form=6&db=m Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15064999&form=6&db=m Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis. causal interaction,unassigned 4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362790&form=6&db=m Effect of H. pylori on COX-2 expression in gastric remnant after distal gastrectomy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15371919&form=6&db=m Influence of gastritis on cyclooxygenase-2 expression before and after eradication of Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15720413&form=6&db=m Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15893277&form=6&db=m Implications of corpus gastritis, atrophy and cyclooxygenase in the development of gastric erosions after curing Helicobacter pylori infection. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15949425&form=6&db=m [COX-2 expression in the H. pylori infected gastric mucosal epithelia and its significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16184416&form=6&db=m The role of cyclooxygenase in gastric mucosal protection. causal interaction,unassigned 3,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247189&form=6&db=m Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17199977&form=6&db=m [Expression of peroxisome proliferators-activated receptor-gamma and cyclooxygenase-2 in Helicobacter pylori infection-associated diseases and significance thereof] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17303342&form=6&db=m Increase in gastric acid-induced afferent input to the brainstem in mice with gastritis. ongoing research,unassigned 4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17926530&form=6&db=m [The choice of selective COX-2 inhibitors] therapeutic application,unassigned 2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18059022&form=6&db=m 4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils. diagnostic usage,unassigned 3,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18301460&form=6&db=m Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571838&form=6&db=m The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18628177&form=6&db=m Supportive care of elderly patients with cancer. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18775915&form=6&db=m Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18825488&form=6&db=m Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18985541&form=6&db=m Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19077474&form=6&db=m [The change of cyclooxygenase-2 and inducible nitric oxide synthase in the gastric mucosa one year after eradication of Helicobacter pylori] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107602&form=6&db=m Expression of COX-2 in Stomach Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19118057&form=6&db=m Cyclooxygenase-2 is an independent prognostic factor in gastric carcinoma patients receiving adjuvant chemotherapy and is not associated with EBV infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19522023&form=6&db=m Anti-Helicobacter pylori therapy followed by celecoxib on progression of gastric precancerous lesions. causal interaction,unassigned 4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19621726&form=6&db=m Remnant gastritis should be evaluated histologically rather than endoscopically. unassigned -
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19711347&form=6&db=m Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19797925&form=6&db=m Cross-talk between inducible nitric oxide synthase and cyclooxygenase in Helicobacter-pylori-induced gastritis. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026064&form=6&db=m Prostaglandin E2 prevents Helicobacter-induced gastric preneoplasia and facilitates persistent infection in a mouse model. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353702&form=6&db=m [Gastric carcinoma and chronic gastritis: epigenetic regulation of CDH1 (E-Cadherin), CDKN2A (p16INK4A), PTGS2 (COX-2) and EGFR genes through methylation] causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20388365&form=6&db=m [Quantification of cyclooxygenase-2 methylation in gastric mucosa by denaturing high performance liquid chromatography assay] causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20438867&form=6&db=m Investigation of anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. ongoing research,unassigned 4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22764438&form=6&db=m Evaluation of specific biochemical indicators of Helicobacter pylori-associated gastric cancer in Egypt. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23161322&form=6&db=m Assessment of COX-2 expression presence and severity by immunohistochemical method in patients with chronic active gastritis and intestinal metaplasia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23163139&form=6&db=m [Exploration of the correlation between Chinese medicine syndrome types of verrucous gastritis and the pressions of gastric mucosal hypoxia-inducible factor-1alpha as well as downstream molecules]. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127267&form=6&db=m A positive feedback loop between STAT3 and cyclooxygenase-2 gene may contribute to Helicobacter pylori-associated human gastric tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24714295&form=6&db=m Expression of cyclooxygenase-2 in gastritis and gastric premalignant lesions. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26674784&form=6&db=m Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,2
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870269&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and interleukin-32 in primary gastric B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232941&form=6&db=m JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056333&form=6&db=m [Recommendation for the prevention and treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal ulcers and its complications]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28946145&form=6&db=m Impact of Cyclooxygenase-2 1195 G-Carrier Genotype Associated with Intestinal Metaplasia and Endoscopic Findings Based on Kyoto Classification. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31073922&form=6&db=m Safety of Cyclooxygenase-2 Inhibitors in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31611922&form=6&db=m Anti-Inflammatory Effects of Licania macrocarpa Cuatrec Methanol Extract Target Src- and TAK1-Mediated Pathways. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734260&form=6&db=m Baicalin protects against ethanol-induced chronic gastritis in rats by inhibiting Akt/NF-?B pathway. therapeutic application,unassigned 1,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32199598&form=6&db=m Cyclooxigenase-2 and osteopontin in gastric pre-neoplastic lesions in relation to H-pylori infection and grade of inflammation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32617046&form=6&db=m Gastroprotective effects of the nonsaponin fraction of Korean Red Ginseng through cyclooxygenase-1 upregulation. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Gastritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34471638&form=6&db=m Uncovering the Mechanisms and Molecular Targets of Weibing Formula 1 against Gastritis: Coupling Network Pharmacology with GEO Database. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819707&form=6&db=m Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection, histological types and staging. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086403&form=6&db=m In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12645788&form=6&db=m Gene expression of ornithine decarboxylase, cyclooxygenase-2, and gastrin in atrophic gastric mucosa infected with Helicobacter pylori before and after eradication therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883469&form=6&db=m H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPAR gamma and impaired apoptosis in gastric carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15949425&form=6&db=m [COX-2 expression in the H. pylori infected gastric mucosal epithelia and its significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762620&form=6&db=m Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese population. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16925606&form=6&db=m Pathogenesis of Helicobacter pylori Infection. unassigned -
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17199977&form=6&db=m [Expression of peroxisome proliferators-activated receptor-gamma and cyclooxygenase-2 in Helicobacter pylori infection-associated diseases and significance thereof] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19954066&form=6&db=m [Association between promoter methylation of cyclooxygenase-2 and expression, and precancerous gastric lesions in a high-risk population] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446925&form=6&db=m The value of MG7-Ag and COX-2 for predicting malignancy in gastric precancerous lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Gastritis, Atrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26674784&form=6&db=m Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,2
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11172698&form=6&db=m Gastroesophageal reflux disease (GERD): current agents and future perspective. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15249402&form=6&db=m Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585388&form=6&db=m Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16210398&form=6&db=m Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis. causal interaction,unassigned 3,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16863546&form=6&db=m Antireflux surgery normalizes cyclooxygenase-2 expression in squamous epithelium of the distal esophagus. causal interaction,unassigned 3,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17031101&form=6&db=m Gastroesophageal reflux disease. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17439595&form=6&db=m Induction of prostaglandin E synthase by gastroesophageal reflux contents in normal esophageal epithelial cells and esophageal cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581270&form=6&db=m COX-2 CA-Haplotype Is a Risk Factor for the Development of Esophageal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17619937&form=6&db=m COX-2 mRNA expression is significantly increased in acid-exposed compared to nonexposed squamous epithelium in gastroesophageal reflux disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18783518&form=6&db=m Helicobacter pylori and non-malignant diseases. therapeutic application,unassigned 1,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19120900&form=6&db=m What is the clinical significance of stromal angiogenesis in Barrett's esophagus? causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19679052&form=6&db=m Immunohistochemical analysis of selected molecular markers in esophagus precancerous, adenocarcinoma and squamous cell carcinoma in Iranian subjects. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25554985&form=6&db=m Esophagoprotective activity of angiotensin-(1-7) in experimental model of acute reflux esophagitis. Evidence for the role of nitric oxide, sensory nerves, hypoxia-inducible factor-1alpha and proinflammatory cytokines. therapeutic application,unassigned 1,0
1.14.99.1 Gastroesophageal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29948304&form=6&db=m A case-control study of the risk of upper gastrointestinal mucosal injuries in patients prescribed concurrent NSAIDs and antithrombotic drugs based on data from the Japanese national claims database of 13 million accumulated patients. therapeutic application,unassigned 4,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9867026&form=6&db=m [Expression of COX-1 and COX-2 and gastrointestinal diseases] ongoing research,unassigned 4,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10789661&form=6&db=m Cyclooxygenase 2 selective agents and upper gastrointestinal disease. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10789662&form=6&db=m Cyclooxygenase 2 selective agents and upper gastrointestinal disease. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11954006&form=6&db=m The iatrogenic costs of NSAID therapy: a population study. causal interaction,unassigned 2,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12510364&form=6&db=m [Recent development of selective cyclooxygenase-2 inhibitors] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15527674&form=6&db=m Is no NSAID a good NSAID? Approaches to NSAID-associated upper gastrointestinal disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15973582&form=6&db=m Digestive Disease Week 2001. COX-2 and gastrointestinal disease. 20-23 May 2001, Atlanta, GA, USA. unassigned -
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20934379&form=6&db=m Chromatin and DNA methylation dynamics of Helicobacter pylori-induced COX-2 activation. causal interaction,unassigned 4,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22950507&form=6&db=m Nicotine and Gastrointestinal Disorders: Its Role in Ulceration and Cancer Development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25446121&form=6&db=m Prostaglandin potentiates 5-HT responses in stomach and ileum innervating visceral afferent sensory neurons. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Gastrointestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34290607&form=6&db=m Genetic Variants in PTGS1 and NOS3 Genes Increase the Risk of Upper Gastrointestinal Bleeding: A Case-Control Study. therapeutic application,unassigned 1,0
1.14.99.1 Gastrointestinal Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693324&form=6&db=m Determinants of selective cyclooxygenase-2 inhibitor prescribing: are patient or physician characteristics more important? causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Gastrointestinal Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15096449&form=6&db=m Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastrointestinal Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15668365&form=6&db=m Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Gastrointestinal Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17146090&form=6&db=m Changes in rates of upper gastrointestinal hemorrhage after the introduction of cyclooxygenase-2 inhibitors in British Columbia and Ontario. therapeutic application,unassigned 4,0
1.14.99.1 Gastrointestinal Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381949&form=6&db=m The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,2
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8931116&form=6&db=m Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888205&form=6&db=m Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10070951&form=6&db=m Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10616198&form=6&db=m Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11023534&form=6&db=m Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11055820&form=6&db=m COX-2-Specific inhibitors--the emergence of a new class of analgesic and anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11228545&form=6&db=m Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11273781&form=6&db=m Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11289104&form=6&db=m Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336566&form=6&db=m COX-2 inhibitors vs. NSAIDs in gastrointestinal damage and prevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401676&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in skin cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11774276&form=6&db=m Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086403&form=6&db=m In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12483244&form=6&db=m Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664575&form=6&db=m Expression of cycloxygenase-2 in human bladder and renal cell carcinoma. unassigned -
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902867&form=6&db=m COX-2 inhibitors as radiation sensitizers for upper GI tract cancers: esophagus, stomach, and pancreas. causal interaction,unassigned 4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12948419&form=6&db=m [Expression and significance of cyclooxygenase-2 in human pancreatic carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15285921&form=6&db=m Cyclooxygenase-2 and gastrointestinal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298620&form=6&db=m Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15334675&form=6&db=m Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574495&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622477&form=6&db=m Correlation between cyclooxygenase-2, proliferative activity, and mucin phenotype in human advanced gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15887126&form=6&db=m The role of prostaglandins and other eicosanoids in the gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247189&form=6&db=m Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552798&form=6&db=m Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16700663&form=6&db=m Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17224647&form=6&db=m Effect of celecoxib on E-cadherin, VEGF, Microvessel density and apoptosis in gastric cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17691999&form=6&db=m Prevention of cancer in the upper gastrointestinal tract with COX-inhibition. Still an option? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17960625&form=6&db=m Dietary supplementation with carbonate increases expression of ornithine decarboxylase and proliferation in gastric mucosa in a rat model of gastric cancer. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18362501&form=6&db=m Cyclooxygenase-2 expression in human thyroid disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632220&form=6&db=m COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18648741&form=6&db=m Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19031117&form=6&db=m Cyclooxygenase-2 (COX-2) in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20381235&form=6&db=m Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20809087&form=6&db=m Association of COX-2 Promoter Polymorphism with Gastrointestinal Tract Cancer in Iran. ongoing research,unassigned 2,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21386635&form=6&db=m Translational Research in Pancreatic Cancer. Highlights from the "2011 ASCO Gastrointestinal Cancers Symposium". San Francisco, CA, USA. January 20-22, 2011. unassigned -
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479450&form=6&db=m A polymorphism in the 3'-utr of cyclooxygenase-2 and the risk of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28405152&form=6&db=m Association between COX-2 -1195G>A polymorphism and gastrointestinal cancer risk: A meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Gastrointestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29982219&form=6&db=m Maintenance use of non-steroidal anti-inflammatory drugs and risk of gastrointestinal cancer in a nationwide population-based cohort study in Sweden. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16455468&form=6&db=m Cyclooxygenase-2 expression and clinical outcome in gastrointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17230613&form=6&db=m Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260469&form=6&db=m Coexpression of cyclooxygenase-2 and vascular endothelial growth factor in gastrointestinal stromal tumor: possible relations to pathological parameters and clinical behavior. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19845533&form=6&db=m Cyclooxygenase-2 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21133589&form=6&db=m Cyclooxygenase-2 expression in gastrointestinal stromal tumours. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22654456&form=6&db=m Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26131278&form=6&db=m Expression of matrix metalloproteinase-9, cyclooxygenase-2 and vascular endothelial growth factor are increased in gastrointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Gastrointestinal Stromal Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31507153&form=6&db=m Expressions of cyclooxygenase 2 in gastrointestinal stromal tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Gastroparesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12813371&form=6&db=m Effects of ketamine/xylazine on expression of tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclo-oxygenase-2 in rat gastric mucosa during endotoxemia. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Gastroparesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16615000&form=6&db=m Effects of lipopolysaccharide on gastric stasis: role of cyclooxygenase. ongoing research,unassigned 4,0
1.14.99.1 Gastroparesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244169&form=6&db=m Effects of cyclooxygenase-2 inhibitor on glucagon-induced delayed gastric emptying and gastric dysrhythmia in dogs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Gastroschisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16460959&form=6&db=m Celosomy is associated with prenatal exposure to cyclooxygenase inhibitors. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Gastroschisis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33454433&form=6&db=m New insights into the obligatory nature of cyclooxygenase-2 and PGE2 during early chick embryogenesis. therapeutic application,unassigned 1,0
1.14.99.1 Genetic Diseases, Inborn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523457&form=6&db=m Selective cyclooxygenase-2 inhibition: a target in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Giant Cell Tumor of Bone http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218139&form=6&db=m [Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis] diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Giant Cell Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218139&form=6&db=m [Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis] diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Gingival Overgrowth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124319&form=6&db=m Elevated levels of cyclooxygenase 1 and 2 in human cyclosporine induced gingival overgrowth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Gingivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8276984&form=6&db=m Flurbiprofen in the prevention and treatment of experimental gingivitis. ongoing research,unassigned 3,0
1.14.99.1 Gingivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17451546&form=6&db=m The effect of age on prostaglandin-synthesizing enzymes in the development of gingivitis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Gingivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22324469&form=6&db=m Cox-2 Expression in Gingival Biopsies From Periodontal Patients is Correlated With Connective Tissue Loss. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Gingivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26430761&form=6&db=m Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Gingivitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743292&form=6&db=m Cyclooxygenase-2 and matrix metalloproteinase-9 expressions correlate with tissue inflammation degree in periodontal disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9395775&form=6&db=m Induction of rabbit cyclooxygenase 2 in the anterior uvea following glaucoma filtration surgery. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9441697&form=6&db=m Cyclooxygenase-1 and cyclooxygenase-2 in the human optic nerve head. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11384149&form=6&db=m Constitutive expression and localization of COX-1 and COX-2 in rabbit iris and ciliary body. diagnostic usage,unassigned 1,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11581208&form=6&db=m Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14736236&form=6&db=m Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14738509&form=6&db=m Enhanced expression of cyclooxygenase-2 in glaucomatous dog eyes. causal interaction,unassigned 4,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17168813&form=6&db=m The function of the selective inhibitors of cyclooxygenase 2. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17172885&form=6&db=m Corneal toxicity from topical ocular and systemic medications. therapeutic application,unassigned 4,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19234234&form=6&db=m Pathophysiology of cyclooxygenase inhibition in animal models. causal interaction,unassigned 4,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19578520&form=6&db=m Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20373895&form=6&db=m Aqueous humor endothelin-1 (Et-1), vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) levels in Mexican glaucomatous patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29665040&form=6&db=m Discovery, characterization and clinical utility of prostaglandin agonists for the treatment of glaucoma. therapeutic application,unassigned 3,0
1.14.99.1 Glaucoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32666339&form=6&db=m Betalain exerts a protective effect against glaucoma is majorly through the association of inflammatory cytokines. ongoing research,unassigned 1,0
1.14.99.1 Glaucoma, Angle-Closure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11581208&form=6&db=m Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11384149&form=6&db=m Constitutive expression and localization of COX-1 and COX-2 in rabbit iris and ciliary body. diagnostic usage,unassigned 1,0
1.14.99.1 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16076963&form=6&db=m Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism. ongoing research,unassigned 2,0
1.14.99.1 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256948&form=6&db=m Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16330497&form=6&db=m R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19953083&form=6&db=m Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure. causal interaction,unassigned 2,0
1.14.99.1 Glaucoma, Open-Angle http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25339146&form=6&db=m Influence of PTGS1, PTGFR, and MRP4 genetic variants on intraocular pressure response to latanoprost in Chinese primary open-angle glaucoma patients. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2234352&form=6&db=m Ultrastructural evidence for differentiation in a human glioblastoma cell line treated with inhibitors of eicosanoid metabolism. ongoing research,unassigned 4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10229132&form=6&db=m Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10483780&form=6&db=m Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987308&form=6&db=m Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121536&form=6&db=m Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,1
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389063&form=6&db=m Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12089724&form=6&db=m Cyclooxygenase-2 (COX-2) expression by immunohistochemistry in glioblastoma multiforme. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726653&form=6&db=m Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15088099&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15105053&form=6&db=m Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15118886&form=6&db=m Inhibition of the arachidonic acid metabolism blocks endothelial cell migration and induces apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383564&form=6&db=m Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15484698&form=6&db=m Cyclooxygenase-2 in oligodendroglioma: possible prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15561105&form=6&db=m The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15565458&form=6&db=m Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme. therapeutic application,unassigned 4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816645&form=6&db=m Differential cyclooxygenase-2 enzyme expression in radiosensitive versus radioresistant glioblastoma multiforme cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16133570&form=6&db=m Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16482921&form=6&db=m [Expression of cyclooxygenase (COX)-2 in astrocytic tumors and anti-tumor effects of selective COX-2 inhibitors] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550738&form=6&db=m Inducible cyclooxygenase (COX-2) in glioblastoma--clinical and immunohistochemical (COX-2-VEGF) correlations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17293239&form=6&db=m Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369862&form=6&db=m Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17440835&form=6&db=m Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006935&form=6&db=m An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18181832&form=6&db=m Cyclooxygenase-2 (Cox-2) expression and angiogenesis in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18346464&form=6&db=m Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19272160&form=6&db=m A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19706164&form=6&db=m Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19934343&form=6&db=m The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20052522&form=6&db=m Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20195390&form=6&db=m The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382140&form=6&db=m mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21054139&form=6&db=m Celecoxib and radioresistant glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects. Laboratory investigation. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763448&form=6&db=m Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22406049&form=6&db=m miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24621265&form=6&db=m Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1? and A? between glial and neuron cells. ongoing research,unassigned 4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24659686&form=6&db=m COX-2 overexpression increases malignant potential of human glioma cells through Id1. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202381&form=6&db=m Effect of cycloxygenase-2 silencing on the malignant biological behavior of MCF-7 breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25409926&form=6&db=m Biphasic effects of luteolin on interleukin-1?-induced cyclooxygenase-2 expression in glioblastoma cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25738651&form=6&db=m NFATc1 activation promotes the invasion of U251 human glioblastoma multiforme cells through COX-2. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26334317&form=6&db=m Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26410343&form=6&db=m Olive oil compounds inhibit the paracrine regulation of TNF-?-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression. ongoing research,unassigned 4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26508095&form=6&db=m Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27039073&form=6&db=m Quercetin sensitizes glioblastoma to t-AUCB by dual inhibition of Hsp27 and COX-2 in vitro and in vivo. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27693715&form=6&db=m Cyclooxygenase-2 in glioblastoma multiforme. unassigned -
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27824617&form=6&db=m Tumor-associated macrophages induce vasculogenic mimicry of glioblastoma multiforme through cyclooxygenase-2 activation. causal interaction,unassigned 1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28718447&form=6&db=m Prostaglandin E2 Signaling: Alternative Target for Glioblastoma? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29137258&form=6&db=m Aberrantly activated Cox-2 and Wnt signaling interact to maintain cancer stem cells in glioblastoma. ongoing research,unassigned 3,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29719610&form=6&db=m A drug combination targeting hypoxia induced chemoresistance and stemness in glioma cells. unassigned -
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29860315&form=6&db=m Methylation of hypoxia-inducible factor (HIF)-1? by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30118847&form=6&db=m Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-l-Leucine and its cytotoxicity for normal and cancer human cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30715649&form=6&db=m Cyclooxygenase (COX) Inhibition by Acetyl Salicylic Acid (ASA) Enhances Antitumor Effects of Nitric Oxide in Glioblastoma In Vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31383285&form=6&db=m Gemcitabine, vinorelbine and cyclooxygenase inhibitors in the treatment of glioblastoma. Ultrastructural analyses in C6 glioma in vitro. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31601050&form=6&db=m Mixed-Generation PAMAM G3-G0 Megamer as a Drug Delivery System for Nimesulide: Antitumor Activity of the Conjugate Against Human Squamous Carcinoma and Glioblastoma Cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31652556&form=6&db=m The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPAR? Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31944406&form=6&db=m S1P d20:1, an endogenous modulator of S1P d18:1/S1P2 -dependent signaling. ongoing research,unassigned 2,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435158&form=6&db=m Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33216331&form=6&db=m Effect of Paracetamol in the Proliferation of Glioblastoma Cell Line: The Role of Apoptosis, COX-2 and Cyclin B Expressions. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33916370&form=6&db=m Permeability of Hypogymnia physodes Extract Component-Physodic Acid through the Blood-Brain Barrier as an Important Argument for Its Anticancer and Neuroprotective Activity within the Central Nervous System. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1
1.14.99.1 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33919029&form=6&db=m Cyclooxygenase Inhibition Alters Proliferative, Migratory, and Invasive Properties of Human Glioblastoma Cells In Vitro. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1506857&form=6&db=m Production of soluble autocrine inhibitory factors by human glioma cell lines. therapeutic application,unassigned 1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9729377&form=6&db=m Taurine chloramine inhibits production of nitric oxide and prostaglandin E2 in activated C6 glioma cells by suppressing inducible nitric oxide synthase and cyclooxygenase-2 expression. therapeutic application,unassigned 1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10364464&form=6&db=m Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: the role of COX-1 and MRP. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10483780&form=6&db=m Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873107&form=6&db=m Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987308&form=6&db=m Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181073&form=6&db=m Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389063&form=6&db=m Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11754876&form=6&db=m Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. unassigned -
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11807649&form=6&db=m Cyclo-oxygenase inhibitors and thromboxane synthase inhibitors differentially regulate migration arrest, growth inhibition and apoptosis in human glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11877441&form=6&db=m Transcriptional regulation of cyclooxygenase-1 by histone deacetylase inhibitors in normal human astrocyte cells. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12089724&form=6&db=m Cyclooxygenase-2 (COX-2) expression by immunohistochemistry in glioblastoma multiforme. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576462&form=6&db=m Microglia cyclooxygenase-2 activity in experimental gliomas: possible role in cerebral edema formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693827&form=6&db=m The eicosanoid cascade: possible role in gliomas and meningiomas. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719052&form=6&db=m Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726707&form=6&db=m Glioma growth inhibition by selective COX-2 inhibitors via cyclooxygenase independent pathways: implications for therapy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999366&form=6&db=m Cyclooxygenase-2 inhibitors in glioma therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15015658&form=6&db=m Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15118886&form=6&db=m Inhibition of the arachidonic acid metabolism blocks endothelial cell migration and induces apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15153839&form=6&db=m Cyclooxygenase in the treatment of glioma: its complex role in signal transduction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15201962&form=6&db=m Midkine promoter-based conditionally replicative adenovirus for malignant glioma therapy. unassigned -
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322259&form=6&db=m gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. ongoing research,unassigned 2,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15361550&form=6&db=m Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383564&form=6&db=m Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465602&form=6&db=m Differential effects of interferon-gamma on the expression of cyclooxygenase-2 in high-grade human gliomas versus primary astrocytes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15558802&form=6&db=m Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15561105&form=6&db=m The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16006736&form=6&db=m Ephedorae herba decreases lipopolysaccharide-induced cyclooxgenase-2 protein expression and NF-kappaB-dependent transcription in C6 rat glioma cells. ongoing research,unassigned 4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16050135&form=6&db=m Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16260090&form=6&db=m Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells. unassigned -
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619662&form=6&db=m Induction of macrophagic prostaglandin E2 synthesis by glioma cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685418&form=6&db=m Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16709027&form=6&db=m Antitumor properties of dimethyl-celecoxib, a derivative of celecoxib that does not inhibit cyclooxygenase-2: implications for glioma therapy. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778966&form=6&db=m [Inhibiting cerebral glioma growth with continuous low-dose chemotherapy and cyclooxygenase-2 inhibitor in nude mice] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16868662&form=6&db=m Cyclooxygenase-2 expression in astrocytomas. Relationship with microvascular parameters, angiogenic factors expression and survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16891468&form=6&db=m Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17447009&form=6&db=m Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616668&form=6&db=m EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17695552&form=6&db=m Celecoxib increased expression of 14-3-3sigma and induced apoptosis of glioma cells. unassigned -
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17729162&form=6&db=m Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition: independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18240928&form=6&db=m Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18332649&form=6&db=m Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606162&form=6&db=m Adenosine rescues glioma cells from cytokine-induced death by interfering with the signaling network involved in nitric oxide production. causal interaction,unassigned 2,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19024162&form=6&db=m Engineering of clinical glioma treatment: prediction of pro-invasive molecular events in treated gliomas. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19029777&form=6&db=m Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line, U87MG. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19169273&form=6&db=m Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein kinase C-delta. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19252746&form=6&db=m COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19272160&form=6&db=m A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133+ U87 glioblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19347995&form=6&db=m The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19429333&form=6&db=m Bee venom suppresses LPS-mediated NO/iNOS induction through inhibition of PKC-alpha expression. therapeutic application,unassigned 1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19639178&form=6&db=m Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19904526&form=6&db=m Protective effect of verbascoside in activated C6 glioma cells: possible molecular mechanisms. causal interaction,unassigned 3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925030&form=6&db=m Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925564&form=6&db=m Snail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20052522&form=6&db=m Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20195390&form=6&db=m The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382140&form=6&db=m mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20411591&form=6&db=m Bradykinin-induced cell migration and COX-2 production mediated by the bradykinin B1 receptor in glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20879982&form=6&db=m Exploiting cyclooxygenase-(in)dependent properties of COX-2 inhibitors for malignant glioma therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21067299&form=6&db=m Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21094175&form=6&db=m Cytosolic and calcium-independent phospholipase A(2) mediate glioma-enhanced proangiogenic activity of brain endothelial cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21220497&form=6&db=m Celecoxib can induce vascular endothelial growth factor expression and tumor angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21324923&form=6&db=m COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763744&form=6&db=m COX-2 regulates the proliferation of glioma stem like cells. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22114493&form=6&db=m Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells. ongoing research,unassigned 4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22235799&form=6&db=m COX-2 and c-kit expression in canine gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22406049&form=6&db=m miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22442796&form=6&db=m In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells. ongoing research,unassigned 4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22639159&form=6&db=m Mechanisms of immune evasion by gliomas. causal interaction,unassigned 1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22767315&form=6&db=m Transcriptional and translational regulation of COX-2 expression by cadmium in C6 glioma cells. ongoing research,unassigned 4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23263903&form=6&db=m Plausible role of naringenin against cerebrally implanted C6 glioma cells in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23299462&form=6&db=m MicroRNA-107 inhibits glioma cell migration and invasion by modulating Notch2 expression. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23635401&form=6&db=m Transcription Factor Interactions Mediate EGF-Dependent COX-2 Expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23651189&form=6&db=m Integration of epidemiology, immunobiology, and translational research for brain tumors. unassigned -
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24064546&form=6&db=m Overexpression of S100A9 in human glioma and in-vitro inhibition by aspirin. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24287292&form=6&db=m Endothelial PKC?-MAPK/ERK-phospholipase A2 pathway activation as a response of glioma in a triple culture model. A new role for pericytes? causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24308155&form=6&db=m Enhancement of antitumor activity by combination of tumor lysate-pulsed dendritic cells and celecoxib in a rat glioma model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24659686&form=6&db=m COX-2 overexpression increases malignant potential of human glioma cells through Id1. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24878890&form=6&db=m Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25646654&form=6&db=m Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25912457&form=6&db=m Cyclooxygenase-2 inhibitor prevents radiation-enhanced infiltration of F98 glioma cells in brain of Fischer rat. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25966079&form=6&db=m Association between genetic polymorphisms of PTGS2 and glioma in a Chinese population. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26097553&form=6&db=m HGF/MET signaling promotes glioma growth via up-regulation of Cox-2 expression and PGE2 production. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328537&form=6&db=m Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629939&form=6&db=m Inhibition of Glioblastoma Cell Growth In Vitro and In Vivo by Brucine, a Component of Chinese Medicine. causal interaction,unassigned 2,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26708701&form=6&db=m Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26871579&form=6&db=m Use of Selective Cyclooxygenase-2 Inhibitors, Other Analgesics, and Risk of Glioma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26927686&form=6&db=m Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27073629&form=6&db=m Cyclooxygenase inhibitor induces the upregulation of connexin-43 expression in C6 glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27609291&form=6&db=m Glioma-secreted soluble factors stimulate microglial activation: The role of interleukin-1? and tumor necrosis factor-?. ongoing research,unassigned 2,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27698824&form=6&db=m miR-101 inhibits glioma cell invasion via the downregulation of COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28243617&form=6&db=m Data supporting the inability of indomethacin to induce autophagy in U251 glioma cells. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28255114&form=6&db=m [MiR-26b inhibits proliferation, invasion, and migration of glioma by targeting cyclooxygenase-2]. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28306608&form=6&db=m Evaluation of human glioma using in-vivo proton magnetic resonance spectroscopy combined with expression of cyclooxygenase-2: a preliminary clinical trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28333553&form=6&db=m Cyclooxygenase-2 Induction by Amino Acid Deprivation Requires p38 Mitogen-Activated Protein Kinase in Human Glioma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789345&form=6&db=m Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28800785&form=6&db=m MiR-26b Mimic Inhibits Glioma Proliferation In Vitro and In Vivo Suppressing COX-2 Expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,1
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29335864&form=6&db=m Ethanol extract of Lycopodium serratum Thunb. Attenuates lipopolysaccharide-induced C6 glioma cells migration via matrix metalloproteinase-9 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29524580&form=6&db=m MicroRNA-128 inhibits proliferation and invasion of glioma cells by targeting COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29719610&form=6&db=m A drug combination targeting hypoxia induced chemoresistance and stemness in glioma cells. unassigned -
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30715649&form=6&db=m Cyclooxygenase (COX) Inhibition by Acetyl Salicylic Acid (ASA) Enhances Antitumor Effects of Nitric Oxide in Glioblastoma In Vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740906&form=6&db=m Activation of PTGS2/NF-?B signaling pathway enhances radiation resistance of glioma. ongoing research,unassigned 4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740911&form=6&db=m Isoalantolactone inhibits IKK? kinase activity to interrupt the NF-?B/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30761522&form=6&db=m Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31383285&form=6&db=m Gemcitabine, vinorelbine and cyclooxygenase inhibitors in the treatment of glioblastoma. Ultrastructural analyses in C6 glioma in vitro. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31438982&form=6&db=m Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31652556&form=6&db=m The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPAR? Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435158&form=6&db=m Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32545774&form=6&db=m Aspirin Induced Glioma Apoptosis through Noxa Upregulation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32615261&form=6&db=m Celecoxib substituted biotinylated poly(amidoamine) G3 dendrimer as potential treatment for temozolomide resistant glioma therapy and anti-nematode agent. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33669933&form=6&db=m ?-Conotoxins and ?-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells. unassigned -
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34091208&form=6&db=m Design, synthesis and biological evaluation of N-anthraniloyl tryptamine derivatives as pleiotropic molecules for the therapy of malignant glioma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34275785&form=6&db=m Expression of RhoA and COX-2 and their roles in the occurrence and progression of brain glioma. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0
1.14.99.1 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34301977&form=6&db=m Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-?B/MDR1 pathway. ongoing research,unassigned 4,0
1.14.99.1 Glioma, Subependymal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17080719&form=6&db=m Expression of cyclo-oxygenase-2 in ependymal tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Gliosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10229132&form=6&db=m Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Gliosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11772429&form=6&db=m A cyclooxygenase-2 (COX-2) inhibitor compared with dexamethasone in a survival study of rats with intracerebral 9L gliosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,4
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1510121&form=6&db=m Paradoxical exacerbation of leukocyte-mediated glomerulonephritis with cyclooxygenase inhibition. therapeutic application,unassigned 2,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2936143&form=6&db=m Renal effects of cyclooxygenase and thromboxane synthetase inhibitors in dogs with experimental liver disease and in rats with glomerulonephritis. ongoing research,unassigned 4,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7890656&form=6&db=m Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis. therapeutic application,unassigned 1,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9513902&form=6&db=m Expression and localization of cyclooxygenase isoforms and cytosolic phospholipase A2 in anti-Thy-1 glomerulonephritis. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9987068&form=6&db=m Cyclooxygenase metabolites mediate glomerular monocyte chemoattractant protein-1 formation and monocyte recruitment in experimental glomerulonephritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10560941&form=6&db=m Effect of thromboxane A2 inhibition and antagonism on prostaglandin and leukotriene synthesis in glomerular immune injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10959556&form=6&db=m Upregulation of cyclooxygenase-1 and the PGE2 receptor EP2 in rat and human mesangioproliferative glomerulonephritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961014&form=6&db=m Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15113870&form=6&db=m COX-2 dependent PGE(2) downregulates alpha(v) integrin expression via the EP(3) receptor in cultured mesangial cells. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204297&form=6&db=m Regulatory effects of inducible nitric oxide synthase on cyclooxygenase-2 and heme oxygenase-1 expression in experimental glomerulonephritis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384995&form=6&db=m CCAAT/enhancer-binding protein-delta is induced in mesangial area during the early stages of anti-Thy1.1 glomerulonephritis and regulates cell proliferation and inflammatory gene expression in cultured rat mesangial cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Glomerulonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22147282&form=6&db=m The effect of renal administration of a selective cyclooxygenase-2 inhibitor or stable prostaglandin I(2) analog on the progression of sclerotic glomerulonephritis in rats. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Glomerulonephritis, IGA http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15778012&form=6&db=m Role of cyclooxygenase-2 in deoxynivalenol-induced immunoglobulin a nephropathy. causal interaction,unassigned 2,0
1.14.99.1 Glomerulonephritis, IGA http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15882262&form=6&db=m Small bowel cyclooxygenase 2 (COX-2) expression in patients with IgA nephropathy. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Glomerulonephritis, IGA http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32310965&form=6&db=m Relative risk of end-stage renal disease requiring dialysis in treated ankylosing spondylitis patients compared with individuals without ankylosing spondylitis: A nationwide, population-based, matched-cohort study. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3474470&form=6&db=m Enhanced glomerular prostaglandin formation in experimental membranous nephropathy. ongoing research,unassigned 3,0
1.14.99.1 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9736824&form=6&db=m Different actions of the cyclooxygenase 2 selective inhibitor flosulide in rats with passive Heymann nephritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10571785&form=6&db=m Effect of flosulide, a selective cyclooxygenase 2 inhibitor, on passive heymann nephritis in the rat. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961014&form=6&db=m Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12608557&form=6&db=m Membranous glomerulopathy and acute interstitial nephritis following treatment with celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12649375&form=6&db=m Inhibition of cyclooxygenases reduces complement-induced glomerular epithelial cell injury and proteinuria in passive Heymann nephritis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17603251&form=6&db=m Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Glomerulonephritis, Membranous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18459455&form=6&db=m Analysis of renal immunoexpression of cyclooxygenase-1 and cyclooxygenase-2 in lupus and nonlupus membranous glomerulopathy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Glomerulosclerosis, Focal Segmental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11849393&form=6&db=m Indomethacin protects permeability barrier from focal segmental glomerulosclerosis serum. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Glomerulosclerosis, Focal Segmental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24858719&form=6&db=m Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-?B-mediated COX-2 expression and apoptosis. therapeutic application,unassigned 1,0
1.14.99.1 Glomus Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23595071&form=6&db=m Immunohistochemical demonstration of cyclooxygenase-2 in glomus tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30265586&form=6&db=m Glucocorticoids use in kidney transplant setting. causal interaction,unassigned 1,0
1.14.99.1 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485218&form=6&db=m Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Glucose Intolerance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33065146&form=6&db=m Low-dose lixisenatide protects against early-onset nephropathy induced in diabetic rats. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Goiter http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11889377&form=6&db=m Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Goiter, Nodular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26511970&form=6&db=m Expression of prostaglandin E2 and EP receptors in human papillary thyroid carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7033849&form=6&db=m Indomethacin-induced azotaemia and hyperkalaemia: a case study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974939&form=6&db=m COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16142876&form=6&db=m Prophylactic effect of highly selective COX-2 inhibition in acute monosodium urate crystal induced inflammation in the rat subcutaneous air pouch. therapeutic application,unassigned 4,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17043508&form=6&db=m Dosing of Antirheumatic Drugs in Renal Disease and Dialysis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19828108&form=6&db=m [Inhibiting cyclooxygenase and 5-lipoxygenase activities is an anti-inflammatory mechanism of Huzhang Gout Granule.] ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20363696&form=6&db=m Formulation and evaluation of mouth dissolving tablets of the Etoricoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20374371&form=6&db=m A survey on the management of gout in Malaysia. therapeutic application,unassigned 4,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21967445&form=6&db=m Virtual and In vitro bioassay screening of phytochemical inhibitors from flavonoids and isoflavones against Xanthine oxidase and Cyclooxygenase-2 for gout treatment. therapeutic application,unassigned 2,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23534413&form=6&db=m Virtual and In Vitro Bioassay Screening of Phytochemical Inhibitors from Flavonoids and Isoflavones Against Xanthine Oxidase and Cyclooxygenase-2 for Gout Treatment. therapeutic application,unassigned 3,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26057289&form=6&db=m Nonsteroidal anti-inflammatory drugs for treatment of acute gout. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27763557&form=6&db=m Decrystallization of Crystals Using Gold "Nano-Bullets" and the Metal-Assisted and Microwave-Accelerated Decrystallization Technique. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651867&form=6&db=m Effects of febuxostat on serum cytokines IL-1, IL-4, IL-6, IL-8, TNF-? and COX-2. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Gout http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33978372&form=6&db=m Significance of Serum Markers and Urinary Microalbumin in the Diagnosis of Early Renal Damage in Patients with Gout. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1732553&form=6&db=m Bis basic substituted diaminobenzobisthiazoles as potential antiarthritic agents. therapeutic application,unassigned 2,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6430962&form=6&db=m Role of lipoxygenase products in murine pulmonary granuloma formation. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6607462&form=6&db=m Pharmacological properties of the antiinflammatory agent 10-methylamine-11-H-indeno-[1,2-b]quinolin-11-one (MB432). ongoing research,unassigned 1,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9253772&form=6&db=m [Multiple roles of inducible cyclooxygenase-2 and its selective inhibitors] therapeutic application,unassigned 1,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9414024&form=6&db=m Significant roles of inducible cyclooxygenase (COX)-2 in angiogenesis in rat sponge implants. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,3
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9535546&form=6&db=m Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831332&form=6&db=m Possible background mechanisms of the effectiveness of cyclooxygenase-2 inhibitors in the treatment of rheumatoid arthritis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10814798&form=6&db=m Focal accumulation of cyclooxygenase-1 (COX-1) and COX-2 expressing cells in cerebral malaria. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10821793&form=6&db=m Cyclo-oxygenase-2 enhances basic fibroblast growth factor-induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11338378&form=6&db=m [Endogenous prostaglandins and angiogenesis] causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12518073&form=6&db=m [Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model] causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17447045&form=6&db=m Local administration of WIN 55,212-2 reduces chronic granuloma-associated angiogenesis in rat by inhibiting NF-kappaB activation. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19277698&form=6&db=m Absence of circulating aldosterone attenuates foreign body reaction around surgical sutures. ongoing research,unassigned 2,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455263&form=6&db=m Curcumin potentiates the anti-inflammatory activity of cyclooxygenase inhibitors in the cotton pellet granuloma pouch model. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22153609&form=6&db=m Assessment of clinicopathological characteristics and immunoexpression of COX-2 and IL-10 in oral pyogenic granuloma. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24768588&form=6&db=m Gene expression profiles in granuloma tissue reveal novel diagnostic markers in sarcoidosis. ongoing research,unassigned 2,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25194675&form=6&db=m Anti-inflammatory and antioxidant activities of the methanol extract of Gynura segetum leaf. ongoing research,unassigned 2,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27342269&form=6&db=m Evaluation of anti-inflammatory, analgesic activities, and side effects of some pyrazole derivatives. unassigned -
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28228088&form=6&db=m Aryl/heteroaryl substituted celecoxib derivatives as COX-2 inhibitors: Synthesis, anti-inflammatory activity and molecular docking studies. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29929077&form=6&db=m Design, synthesis and evaluation of some pyrazolo[3,4-d]pyrimidine derivatives bearing thiazolidinone moiety as anti-inflammatory agents. therapeutic application,unassigned 3,0
1.14.99.1 Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32222576&form=6&db=m The flavonoid-enriched extract from the root of Smilax china L. inhibits inflammatory responses via the TLR-4-mediated signaling pathway. therapeutic application,unassigned 1,0
1.14.99.1 Granulomatous Disease, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7964451&form=6&db=m Toxoplasma gondii alters eicosanoid release by human mononuclear phagocytes: role of leukotrienes in interferon gamma-induced antitoxoplasma activity. unassigned -
1.14.99.1 Granulosa Cell Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21131835&form=6&db=m COX-2 expression in nonepithelial ovarian malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1
1.14.99.1 Graves Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717230&form=6&db=m Immunohistochemical expression of COX-2 in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Graves Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27099839&form=6&db=m Adjuvant Treatment of Graves' Disease with Diclofenac: Safety, Effects on Ophthalmopathy and Antibody Concentrations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Graves Ophthalmopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18651822&form=6&db=m Improvement of thyroid eye disease following treatment with the cyclooxygenase-2 selective inhibitor celecoxib. therapeutic application,unassigned 4,0
1.14.99.1 Graves Ophthalmopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23664858&form=6&db=m Pirfenidone attenuates IL-1?-induced COX-2 and PGE2 production in orbital fibroblasts through suppression of NF-?B activity. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Graves Ophthalmopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25342622&form=6&db=m Hyaluronic acid induces COX-2 expression via CD44 in orbital fibroblasts from patients with thyroid-associated ophthalmopathy. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Graves Ophthalmopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27092721&form=6&db=m Celecoxib and Pioglitazone as Potential Therapeutics for Regulating TGF-?-Induced Hyaluronan in Dysthyroid Myopathy. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Graves Ophthalmopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27768856&form=6&db=m Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy. unassigned -
1.14.99.1 Guillain-Barre Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11870698&form=6&db=m New cyclooxygenase-2 inhibitors for treatment of experimental autoimmune neuritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Gynecomastia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16392624&form=6&db=m Possible involvement of aromatase overexpression induced by cyclo-oxygenase-2 in the pathogenesis of idiopathic gynecomastia. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12650805&form=6&db=m Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome. diagnostic usage,unassigned 3,0
1.14.99.1 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12912958&form=6&db=m Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760387&form=6&db=m Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18600394&form=6&db=m Molecular insights into Peutz-Jeghers syndrome: two probands with a germline mutation of LKB1. causal interaction,unassigned 4,0
1.14.99.1 Hamartoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19318548&form=6&db=m Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hand-Foot Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12520638&form=6&db=m Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hand-Foot Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16755175&form=6&db=m Retrospective study of capecitabine and celecoxib in metastatic colorectal cancer: potential benefits and COX-2 as the common mediator in pain, toxicities and survival? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,2
1.14.99.1 Hand-Foot Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21113620&form=6&db=m The effect of COX-2 inhibitor on capecitabine-induced hand-foot syndrome in patients with stage II/III colorectal cancer: a phase II randomized prospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Hashimoto Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587354&form=6&db=m Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6585268&form=6&db=m Prostaglandins in carcinomas of the head and neck. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668483&form=6&db=m Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11326316&form=6&db=m Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745262&form=6&db=m COX-2 expression in dysplasia of the head and neck: correlation with elF4E. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196922&form=6&db=m Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203806&form=6&db=m Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12636206&form=6&db=m In vitro growth inhibition by indomethacin on human oral squamous cell carcinoma lines synergistically suppressed by all-trans retinoic acid correlating to apoptosis. causal interaction,unassigned 1,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12698187&form=6&db=m Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12870656&form=6&db=m Modulation of annexin I and cyclooxygenase-2 in smokeless tobacco-induced inflammation and oral cancer. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552703&form=6&db=m Immune restoration in head and neck cancer patients via cyclooxygenase inhibition: an update. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566822&form=6&db=m The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15155138&form=6&db=m Emerging drugs for head and neck cancer. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15194215&form=6&db=m Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319254&form=6&db=m Cyclooxygenase-2 inhibitor and cisplatin combination as a radiosensitizer in the treatment of head and neck cancer patients. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16170038&form=6&db=m Interaction between epidermal growth factor receptor- and cyclooxygenase 2-mediated pathways and its implications for the chemoprevention of head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16240325&form=6&db=m The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273249&form=6&db=m Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head and neck cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17224518&form=6&db=m Head and neck cancer recurrence and mortality in nonselective cyclooxygenase inhibitor users. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17354234&form=6&db=m Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17364333&form=6&db=m Expression of cyclooxygenase-2 mRNA in peripheral blood of head and neck cancer patients and in healthy controls. A pilot study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17387473&form=6&db=m Immune restoration in head and neck cancer patients after in vivo COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624243&form=6&db=m Cyclooxygenase isozymes in oral squamous cell carcinoma:a real-time RT-PCR study with clinic pathological correlations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17764107&form=6&db=m Wnt signaling controls radiosensitivity via cyclooxygenase-2-mediated Ku expression in head and neck cancer. unassigned -
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18172254&form=6&db=m Prognostic significance of cyclooxygenase-2 overexpression in glottic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173552&form=6&db=m Strong evidence for up-regulation of cyclooxygenase-1 in head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19005325&form=6&db=m Recurrent respiratory papillomatosis: update 2008. therapeutic application,unassigned 4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280666&form=6&db=m COX-2 polymorphisms and the risk for head and neck cancer in white patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19554635&form=6&db=m Low COX2 in tumor and upregulation in stroma mark laryngeal squamous cell carcinoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19755515&form=6&db=m Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism. ongoing research,unassigned 4,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19821125&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21246519&form=6&db=m Phase 1 trial of concurrent erlotinib, celecoxib, and reirradiation for recurrent head and neck cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424865&form=6&db=m The correlation between tumor-infiltrating Foxp3+ regulatory T cells and cyclooxygenase-2 expression and their association with recurrence in resected head and neck cancers. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656078&form=6&db=m The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22732263&form=6&db=m Serum biomarker modulation following molecular targeting of epidermal growth factor and cyclooxygenase pathways: A pilot randomized trial in head and neck cancer. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23422093&form=6&db=m Chemoprevention of head and neck cancer by simultaneous blocking of epidermal growth factor receptor and cyclooxygenase-2 signaling pathways: preclinical and clinical studies. unassigned -
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24724948&form=6&db=m Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323811&form=6&db=m Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28301518&form=6&db=m Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31594701&form=6&db=m NSAID therapy for PIK3CA-Altered colorectal, breast, and head and neck cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32161122&form=6&db=m Integrative analysis of multi-omics data identified EGFR and PTGS2 as key nodes in a gene regulatory network related to immune phenotypes in head and neck cancer. causal interaction,unassigned 2,0
1.14.99.1 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33287464&form=6&db=m Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Head Injuries, Closed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10636620&form=6&db=m Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Head Injuries, Closed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23122881&form=6&db=m Effects of selective and non-selective cyclooxygenase inhibition against neurological deficit and brain oedema following closed head injury in mice. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Headache Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1468903&form=6&db=m Low concentrations of lithium and cyclooxygenase inhibitors enhance endothelin-1 (ET-1)-induced contractions in human temporal artery, but not in porcine ophthalmic artery. ongoing research,unassigned 4,0
1.14.99.1 Headache Disorders, Primary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12047458&form=6&db=m COX-2 inhibitor for the treatment of idiopathic stabbing headache secondary to cerebrovascular diseases. therapeutic application,unassigned 4,0
1.14.99.1 Headache Disorders, Primary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18171381&form=6&db=m Primary stabbing headache can be responsive to etoricoxib, a selective COX-2 inhibitor. therapeutic application,unassigned 4,0
1.14.99.1 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2106119&form=6&db=m Salicylate, mefenamate, meclofenamate, and quinine on cochlear potentials. causal interaction,unassigned 4,0
1.14.99.1 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21189050&form=6&db=m Cyclo-oxygenase enzyme in the perilymph of human inner ear. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23826496&form=6&db=m The effect of celecoxib, a cyclooxygenase-2 inhibitor on noise- induced hearing loss. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25779473&form=6&db=m Assessment of the potential ototoxicity of high-dose celecoxib, a selective cyclooxygenase-2 inhibitor, in rats. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Hearing Loss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29042071&form=6&db=m Influence of Ginkgo Biloba extract (EGb 761) on expression of IL-1 Beta, IL-6, TNF-alfa, HSP-70, HSF-1 and COX-2 after noise exposure in the rat cochlea. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Hearing Loss, Noise-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23380763&form=6&db=m Resveratrol Decreases Noise-Induced Cyclooxygenase-2 Expression in the Rat Cochlea. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Hearing Loss, Noise-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26934825&form=6&db=m Inhibition of cyclooxygenase-2 by NS398 attenuates noise-induced hearing loss in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10559835&form=6&db=m Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase. diagnostic usage,unassigned 3,0
1.14.99.1 Heart Arrest http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734378&form=6&db=m Cyclooxygenase inhibition prior to ventricular fibrillation induced ischemia reperfusion injury impairs survival and outcomes. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Heart Defects, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1560290&form=6&db=m Ductus-dependent fetal cardiac defects contraindicate indomethacin tocolysis. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1590442&form=6&db=m Effect of dietary n-3 fatty acids on cerebral microcirculation. unassigned -
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005841&form=6&db=m gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664583&form=6&db=m Cyclooxygenase-2 in human pathological disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15550635&form=6&db=m Medicine. Estrogen's ties to COX-2 may explain heart disease gender gap. unassigned -
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15813652&form=6&db=m Cyclo-oxygenase-2 inhibitors: when should they be used in the elderly? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16041850&form=6&db=m By the way, doctor. I'm confused. I've read your articles about heart disease being caused by inflammation. If the COX-2 drugs are anti-inflammatory, why do they seem to make heart disease worse, not better? unassigned -
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16154096&form=6&db=m Getting to the heart of COX-2 inhibition. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415492&form=6&db=m Prostacyclin in the cardiovascular system: new aspects and open questions. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16922642&form=6&db=m Clinical pharmacology of etoricoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17054845&form=6&db=m [Risk factor assessment of cardiocerebrovascular diseases in patients with rheumatoid arthritis] causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220723&form=6&db=m The role of COX-2 in heart pathology. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19385345&form=6&db=m [Safe use of non-steroidal anti-inflammatory drugs] causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21035466&form=6&db=m Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: Mechanisms of COX-2 inhibitor risk to heart disease. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23985963&form=6&db=m Thromboxane A2 Generation, in the Absence of Platelet COX-1 Activity, in Patients With and Without Atherothrombotic Myocardial Infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24519928&form=6&db=m Cyclooxygenase-2 in Endothelial and Vascular Smooth Muscle Cells Restrains Atherogenesis in Hyperlipidemic Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1796634&form=6&db=m [Renin, aldosterone and prostaglandins in heart failure] causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2066053&form=6&db=m [Role of prostaglandins in regulation of kidney function in heart failure] ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7033849&form=6&db=m Indomethacin-induced azotaemia and hyperkalaemia: a case study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511753&form=6&db=m Effects of acetylsalicylic acid on peripheral hemodynamics in patients with chronic heart failure treated with angiotensin-converting enzyme inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7930256&form=6&db=m Effect of angiotensin-converting enzyme inhibitors on endothelium-dependent peripheral vasodilation in patients with chronic heart failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8603506&form=6&db=m Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase-1 in heart failure. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8856478&form=6&db=m Impaired coronary sensitivity to diltiazem in experimental heart failure: involvement of the cyclooxygenase but not the nitric oxide-synthase pathway. therapeutic application,unassigned 1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9140681&form=6&db=m Coronary and cardiac sensitivity to the vasoselective benzothiazepine-like calcium antagonist, clentiazem, in experimental heart failure. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9330129&form=6&db=m Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679712&form=6&db=m Cyclooxygenase-2 induction in congestive heart failure: friend or foe? unassigned -
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679714&form=6&db=m Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10400007&form=6&db=m Effect of aspirin and ifetroban on skeletal muscle blood flow in patients with congestive heart failure treated with Enalapril. Ifetroban Study Group. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10825178&form=6&db=m Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure. causal interaction,unassigned 2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864134&form=6&db=m Nimesulide: some pharmaceutical and pharmacological aspects--an update. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11055820&form=6&db=m COX-2-Specific inhibitors--the emergence of a new class of analgesic and anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115075&form=6&db=m Cyclooxygenase-2 expression is associated with the renal macula densa of patients with Bartter-like syndrome. unassigned -
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133513&form=6&db=m Intrarenal expression and distribution of cyclooxygenase isoforms in rats with experimental heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11496056&form=6&db=m Does aspirin attenuate the effect of angiotensin-converting enzyme inhibitors in hypertension or heart failure? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11499548&form=6&db=m Expression of cyclooxygenase-2 in the macula densa of human kidney in hypertension, congestive heart failure, and diabetic nephropathy. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11904123&form=6&db=m Worsening heart failure associated with COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12109923&form=6&db=m Cardiovascular risk profile of antirheumatic agents in patients with osteoarthritis and rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12189288&form=6&db=m Pharmacotherapy in congestive heart failure: COX-2 inhibition: a cautionary note in congestive heart failure. therapeutic application,unassigned 2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12189304&form=6&db=m Cyclooxygenase-2 and nuclear factor-kappaB in myocardium of end stage human heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12656651&form=6&db=m Nonsteroidal anti-inflammatory drugs and heart failure. therapeutic application,unassigned 3,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12710523&form=6&db=m Cyclooxygenase-2 (COX-2) in acute myocardial infarction: cellular expression and use of selective COX-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12747814&form=6&db=m [Association between non-steroid antiinflammatory drugs intake and decompensation of heart failure] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691350&form=6&db=m Renal cyclooxygenase-2 (COX-2). Physiological, pathophysiological, and clinical implications. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020525&form=6&db=m Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15023870&form=6&db=m Cyclooxygenase-2 inhibitor treatment improves left ventricular function and mortality in a murine model of doxorubicin-induced heart failure. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172772&form=6&db=m Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study. therapeutic application,unassigned 3,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15500886&form=6&db=m COX-2 inhibitors and risk of heart failure. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15500889&form=6&db=m COX-2 inhibitors and risk of heart failure. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719708&form=6&db=m Rationale for testing the cardiovascular risk for patients with COX-2 inhibitors on the basis of biomarker NT-proBNP. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15813652&form=6&db=m Cyclo-oxygenase-2 inhibitors: when should they be used in the elderly? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15926604&form=6&db=m COX-2 selective nonsteroidal anti-inflammatory drugs: current status. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16354389&form=6&db=m The use of NSAIDs in rheumatic disorders 2005: a global perspective. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16586083&form=6&db=m Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16741783&form=6&db=m Update on guidelines for the treatment of chronic musculoskeletal pain. causal interaction,unassigned 3,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16808550&form=6&db=m Heart failure induced by non-cardiac drugs. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17054845&form=6&db=m [Risk factor assessment of cardiocerebrovascular diseases in patients with rheumatoid arthritis] causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17198778&form=6&db=m Roles of cyclooxygenase-2 and phosphorylated Akt (Thr308) in cardiac hypertrophy regression mediated by left-ventricular unloading. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17242297&form=6&db=m Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaB. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17394181&form=6&db=m Risk of congestive heart failure with nonsteroidal antiinflammatory drugs and selective Cyclooxygenase 2 inhibitors: a class effect? therapeutic application,unassigned 4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437665&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17469317&form=6&db=m [Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173977&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18296564&form=6&db=m Cyclooxygenase products sensitize muscle mechanoreceptors in humans with heart failure. unassigned -
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18311816&form=6&db=m Does tumor necrosis factor alpha inhibition promote or prevent heart failure in patients with rheumatoid arthritis? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18384446&form=6&db=m Selective COX-2 inhibitors, NSAIDs and congestive heart failure: differences between new and recurrent cases. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695943&form=6&db=m Association of non-steroidal anti-inflammatory drugs with outcomes in patients with ST-segment elevation myocardial infarction treated with fibrinolytic therapy: an ExTRACT-TIMI 25 analysis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18760966&form=6&db=m Non-steroidal anti-inflammatory drugs and cardiac failure: meta-analyses of observational studies and randomised controlled trials. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18802217&form=6&db=m A postgenomic integrated view of prostaglandins in reproduction: implications for other body systems. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19376970&form=6&db=m Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630805&form=6&db=m The translational therapeutics of prostaglandin inhibition in atherothrombosis. therapeutic application,unassigned 4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20059330&form=6&db=m Emotion recollected in tranquility: lessons learned from the COX-2 saga. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20170663&form=6&db=m Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20498929&form=6&db=m [Nonsteroidal anti-inflammatory drugs: cardiovascular, cerebrovascular and renal effects] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20539104&form=6&db=m Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale. therapeutic application,unassigned 4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20565461&form=6&db=m Use of non-steroidal anti-inflammatory drugs and risk of incident myocardial infarction and heart failure, and all-cause mortality in the Australian veteran community. ongoing research,unassigned 1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21469214&form=6&db=m Could thiazolidinediones increase the risk of heart failure in Friedreich's ataxia patients? causal interaction,unassigned 4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21855554&form=6&db=m The contribution of prostaglandins versus prostacyclin in ventricular remodeling during heart failure. unassigned -
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23152801&form=6&db=m Inhibition of cyclooxygenase-2 reduces hypothalamic excitation in rats with adriamycin-induced heart failure. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24658325&form=6&db=m TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25305179&form=6&db=m Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure. causal interaction,unassigned 4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748877&form=6&db=m Cardiovascular risks associated with non-aspirin non-steroidal anti-inflammatory drug use. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26385185&form=6&db=m Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26445960&form=6&db=m Mechanism of QSYQ on anti-apoptosis mediated by different subtypes of cyclooxygenase in AMI induced heart failure rats. ongoing research,unassigned 1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26841787&form=6&db=m Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs. therapeutic application,unassigned 4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27762965&form=6&db=m Prescription painkillers linked to greater risk of heart failure. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28569569&form=6&db=m Nonsteroidal anti-inflammatory drugs and cardiovascular safety - translating pharmacological data into clinical readouts. causal interaction,unassigned 2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30232741&form=6&db=m Nonsteroidal Anti-Inflammatory Drugs and Risk of First Hospitalization for Heart Failure in Patients with No History of Heart Failure: A Population-Based Case-Crossover Study. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30245627&form=6&db=m Raging the War Against Inflammation With Natural Products. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30386795&form=6&db=m Interactions between the Cyclooxygenase Metabolic Pathway and the Renin-Angiotensin-Aldosterone Systems: Their Effect on Cardiovascular Risk, from Theory to the Clinical Practice. causal interaction,unassigned 4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31015404&form=6&db=m The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31073922&form=6&db=m Safety of Cyclooxygenase-2 Inhibitors in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31172972&form=6&db=m Eicosanoid profiling in effluent of isolated perfused heart of Tg?q*44 mice with advanced heart failure. therapeutic application,unassigned 1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31229551&form=6&db=m 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32105387&form=6&db=m Metabo and mechanoreceptor expression in human heart failure: relationships with the locomotor muscle afferent influence on exercise responses. causal interaction,unassigned 4,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32848764&form=6&db=m GEO Data Sets Analysis Identifies COX-2 and Its Related Micro RNAs as Biomarkers for Non-Ischemic Heart Failure. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32954541&form=6&db=m No effect of endoperoxide 4 or thromboxane A2 receptor blockade on static mechanoreflex activation in rats with heart failure. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33619313&form=6&db=m Three-dimensional structure of human cyclooxygenase (hCOX)-1. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34234507&form=6&db=m Upregulation of COX-2 and PGE2 Induced by TNF-? Mediated Through TNFR1/MitoROS/PKC?/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34405222&form=6&db=m [Research advances of prostaglandin E2 synthases and receptors in cardiovascular diseases]. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Heart Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633942&form=6&db=m Comparison of cyclooxygenase 2 expression in adenocarcinomas of the gastric cardia and distal oesophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Heart Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623628&form=6&db=m Loss of heterozygosity and immunohistochemistry of adenocarcinomas of the esophagus and gastric cardia. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Heart Septal Defects, Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16298872&form=6&db=m Combined treatment potentiates the developmental toxicity of ibuprofen and acetazolamide in rats. unassigned -
1.14.99.1 Heart Septal Defects, Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16862284&form=6&db=m Congenital ventricular septal defects and prenatal exposure to cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Heart Valve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679714&form=6&db=m Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Helicobacter Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16230370&form=6&db=m Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Helicobacter Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026064&form=6&db=m Prostaglandin E2 prevents Helicobacter-induced gastric preneoplasia and facilitates persistent infection in a mouse model. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Hemangioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19329856&form=6&db=m Increased expression of cyclooxygenase-2 and increased infiltration of regulatory T cells in tumors of patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Hemangioma, Capillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25807908&form=6&db=m CD105 expression in oral capillary hemangiomas and cavernous hemangiomas. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Hemangioma, Cavernous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25807908&form=6&db=m CD105 expression in oral capillary hemangiomas and cavernous hemangiomas. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Hemangiosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15872381&form=6&db=m Assessment of cyclooxygenase-2 expression in canine hemangiosarcoma, histiocytic sarcoma, and mast cell tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,3
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102577&form=6&db=m The emerging role of angiogenesis inhibitors in hematologic malignancies. therapeutic application,unassigned 2,0
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701860&form=6&db=m Targeting cyclooxygenase-2 reduces overt toxicity toward low-dose vinblastine and extends survival of juvenile mice with Friend disease. therapeutic application,unassigned 4,0
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15731178&form=6&db=m Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691115&form=6&db=m Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236750&form=6&db=m [Effect of As(2)O(3) on Expressions of COX-2 and Matrix Metalloproteinases in SGC7901 and K562 Cells.] causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20339581&form=6&db=m The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187081&form=6&db=m Cyclooxygenase-2 in oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21895406&form=6&db=m Leukemic cells modulate induction of COX-2 in human stromal fibroblasts. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971811&form=6&db=m Interrelationship and expression profiling of cyclooxygenase and angiogenic factors in Indian patients with multiple myeloma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23435965&form=6&db=m Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24883266&form=6&db=m The influence of Cox-2 and bioactive lipids on hematological cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hematologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683818&form=6&db=m The cyclooxygenase-2/prostaglandin E2 pathway and its role in the pathogenesis of human and dog hematological malignancies. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Hematoma, Subdural, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20099472&form=6&db=m Possible role of cyclooxygenase-2 in developing chronic subdural hematoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Hematuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=861066&form=6&db=m Association of renal papillary necrosis and ankylosing spondylitis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Hematuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824517&form=6&db=m Cyclooxygenase-1 and -2 expression in urothelial carcinomas of the urinary bladder in cows. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Hematuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15882262&form=6&db=m Small bowel cyclooxygenase 2 (COX-2) expression in patients with IgA nephropathy. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Hematuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22634839&form=6&db=m Scutellaria baicalensis alleviates cantharidin-induced rat hemorrhagic cystitis through inhibition of cyclooxygenase-2 overexpression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,2
1.14.99.1 Hemophilia A http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15876269&form=6&db=m Rofecoxib as adjunctive therapy for haemophilic arthropathy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hemophilia A http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26899022&form=6&db=m Is the cardiovascular toxicity of NSAIDS and COX-2 selective inhibitors underestimated in patients with haemophilia? causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Hemophilia A http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34042011&form=6&db=m Pain management in people with hemophilia in childhood and young adulthood. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Hemorrhagic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12574546&form=6&db=m Risk of stroke associated with nonsteroidal anti-inflammatory drugs: a nested case-control study. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hemorrhagic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16671425&form=6&db=m Pharmacological brain cooling with indomethacin in acute hemorrhagic stroke: antiinflammatory cytokines and antioxidative effects. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Hemorrhagic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27072959&form=6&db=m Significance of cyclooxygenase-2 elevation in middle cerebral artery for patients with hemorrhagic moyamoya disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16911697&form=6&db=m Lack of detrimental or therapeutic effects of cyclooxygenase inhibition in bile duct-ligated rats with hepatic encephalopathy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Hepatic Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575628&form=6&db=m Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Hepatic Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14517196&form=6&db=m Pharmacokinetics of etoricoxib in patients with hepatic impairment. ongoing research,unassigned 1,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1679189&form=6&db=m Effect of dietary alpha-linolenate/linoleate balance on endotoxin-induced hepatitis in mice. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121637&form=6&db=m Impaired lipopolysaccharide-inducible tumor necrosis factor production in vitro by peripheral blood monocytes of patients with viral hepatitis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3729968&form=6&db=m A novel biologically active seleno-organic compound--VI. Protection by ebselen (PZ 51) against galactosamine/endotoxin-induced hepatitis in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12201873&form=6&db=m Cyclooxygenase-2 mRNA is up-regulated in cirrhotic or chronic hepatitis liver adjacent to hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452750&form=6&db=m Acute cholestatic hepatitis associated with celecoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594587&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase in omental arteries harvested from patients with severe liver diseases: immuno-localization and influence on vascular tone. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12774242&form=6&db=m Cyclo-oxygenase 2 inhibitors: emerging roles in the gut. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678698&form=6&db=m [Role of cyclooxygenase-2 in the pathogenesis of chronic liver diseases] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15377291&form=6&db=m Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15919917&form=6&db=m Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17148503&form=6&db=m Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17555580&form=6&db=m Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18503750&form=6&db=m Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19950766&form=6&db=m [Cholestatic hepatitis associated with nimesulide--a case report] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140976&form=6&db=m [Relationship between cyclooxysenase 2 and serious hepatitis]. therapeutic application,unassigned 1,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21356386&form=6&db=m Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21800055&form=6&db=m Cyclooxygenase-2 -765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22330637&form=6&db=m Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequence. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340386&form=6&db=m Cyclooxygenase-2 promoter polymorphism -899G/C is associated with hepatitis B-related liver cancer in a Chinese population of Gansu province. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23082050&form=6&db=m Theoretical basis of a beneficial role for vitamin D in viral hepatitis. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24496160&form=6&db=m Overexpression of cyclooxygenase-2 and transforming growth factor-beta 1 is an independent predictor of poor virological response to interferon therapy in chronic HCV genotype 4 patients. causal interaction,unassigned 4,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29117589&form=6&db=m Chronic exposure of nanomolar MC-LR caused oxidative stress and inflammatory responses in HepG2 cells. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Hepatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33657087&form=6&db=m A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model. causal interaction,unassigned 1,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11860408&form=6&db=m Expression of cyclooxygenase-2 in chronic hepatitis B and the effects of anti-viral therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488433&form=6&db=m The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010822&form=6&db=m Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218507&form=6&db=m Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319438&form=6&db=m Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963597&form=6&db=m Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFkappaB pathway in a human monocytic cell line, THP-1. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18506760&form=6&db=m Potent cell growth inhibitory effects in hepatitis B virus X protein positive hepatocellular carcinoma cells by the selective cyclooxygenase-2 inhibitor celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18601905&form=6&db=m COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18712978&form=6&db=m Lack of influence of cyclooxygenese-2 expression in hepatocellular carcinomas on patient survival. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19329856&form=6&db=m Increased expression of cyclooxygenase-2 and increased infiltration of regulatory T cells in tumors of patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19940973&form=6&db=m HBx targeting to mitochondria and ROS generation are necessary but insufficient for HBV-induced cyclooxygenase-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20652159&form=6&db=m Overexpression of cyclooxygenase-2 in noncancerous liver tissue increases the postoperative recurrence of hepatocellular carcinoma in patients with hepatitis B virus-related cirrhosis. causal interaction,unassigned 4,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21138631&form=6&db=m [The expression of hepatitis B virus X protein and cyclooxygenase-2 in hepatitis B virus-related hepatocellular carcinoma: correlation with microangiogenesis and metastasis, and what is the possible mechanism]. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21244365&form=6&db=m Endoplasmic Reticulum stress induced by Hepatitis B virus X protein enhances cyclooxygenase 2 expression via activating transcription factor-4. unassigned -
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21401943&form=6&db=m Induction of Cyclooxygenase-2 Expression by Hepatitis B Virus Depends on Demethylation-associated Recruitment of Transcription Factors to the Promoter. ongoing research,unassigned 2,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21800055&form=6&db=m Cyclooxygenase-2 -765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957142&form=6&db=m Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. ongoing research,unassigned 3,0
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22152242&form=6&db=m [Expression of COX-2 and PPARr in the livers of patients with acute on chronic HBV-related liver failure and their relationship with clinic parameters]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1
1.14.99.1 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22834139&form=6&db=m [COX-2 as an early diagnostic marker of virus-associated human malignant neoplasms]. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121637&form=6&db=m Impaired lipopolysaccharide-inducible tumor necrosis factor production in vitro by peripheral blood monocytes of patients with viral hepatitis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11860408&form=6&db=m Expression of cyclooxygenase-2 in chronic hepatitis B and the effects of anti-viral therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218507&form=6&db=m Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15377291&form=6&db=m Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17202846&form=6&db=m Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17845691&form=6&db=m Cyclooxygenase-2 expression in chronic hepatitis C and the effect of interferon alpha treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Hepatitis B, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340386&form=6&db=m Cyclooxygenase-2 promoter polymorphism -899G/C is associated with hepatitis B-related liver cancer in a Chinese population of Gansu province. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632332&form=6&db=m Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350902&form=6&db=m Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver: possible involvement of COX-2 in the angiogenesis of hepatitis C virus-positive cases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12016548&form=6&db=m Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs. therapeutic application,unassigned 3,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12879991&form=6&db=m Hepatotoxicity associated with non-steroidal anti-inflammatory drugs. therapeutic application,unassigned 3,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15479690&form=6&db=m Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15533662&form=6&db=m Plasmon-waveguide resonance spectroscopy applied to three potential drug targets: cyclooxygenase-2, hepatitis C virus RNA polymerase and integrin alpha V beta 3. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15919917&form=6&db=m Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16014934&form=6&db=m Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16643796&form=6&db=m [The effect of HCV core protein on the expression of cyclooxygenase 2 (COX-2) in HepG2 cells] ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17688665&form=6&db=m Overexpressed cyclo-oxygenase-2 in the background liver is associated with the clinical course of hepatitis C virus-related cirrhosis patients after curative surgery for hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17845691&form=6&db=m Cyclooxygenase-2 expression in chronic hepatitis C and the effect of interferon alpha treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17964630&form=6&db=m NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18393288&form=6&db=m Acetylsalicylic acid inhibits hepatitis C virus RNA and protein expression through cyclooxygenase 2 signaling pathways. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18712978&form=6&db=m Lack of influence of cyclooxygenese-2 expression in hepatocellular carcinomas on patient survival. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19794231&form=6&db=m Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20880066&form=6&db=m Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21692943&form=6&db=m San-Huang-Xie-Xin-Tang extract suppresses hepatitis C virus replication and virus-induced cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23469054&form=6&db=m Aqueous Extract of the Edible Gracilaria tenuistipitata Inhibits Hepatitis C Viral Replication via Cyclooxygenase-2 Suppression and Reduces Virus-Induced Inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24496160&form=6&db=m Overexpression of cyclooxygenase-2 and transforming growth factor-beta 1 is an independent predictor of poor virological response to interferon therapy in chronic HCV genotype 4 patients. causal interaction,unassigned 4,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25305454&form=6&db=m Hepatitis C virus NS3 protein enhances cancer cell invasion by activating matrix metalloproteinase-9 and cyclooxygenase-2 through ERK/p38/NF-?B signal cascade. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483263&form=6&db=m New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2. therapeutic application,unassigned 2,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25547723&form=6&db=m Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. causal interaction,unassigned 1,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28317866&form=6&db=m Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786110&form=6&db=m Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review). causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hepatitis C http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29875371&form=6&db=m Lobohedleolide suppresses hepatitis C virus replication via JNK/c-Jun-C/EBP-mediated down-regulation of cyclooxygenase-2 expression. unassigned -
1.14.99.1 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7740291&form=6&db=m [Treatment of chronic virus hepatitis with acetylsalicylic acid] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15304245&form=6&db=m Platelet sparing effect of COX II inhibition used with pegylated interferon alfa-2a for the treatment of chronic hepatitis C: a short term pilot study. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15479690&form=6&db=m Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16800815&form=6&db=m Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells. causal interaction,unassigned 3,0
1.14.99.1 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17845691&form=6&db=m Cyclooxygenase-2 expression in chronic hepatitis C and the effect of interferon alpha treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18049160&form=6&db=m Response to antiviral therapy and hepatic expression of cyclooxygenases in chronic hepatitis C. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,4
1.14.99.1 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18092051&form=6&db=m Expression of cyclooxygenase-2 and transforming growth factor-beta1 in HCV-induced chronic liver disease and hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Hepatitis C, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22863264&form=6&db=m Genetic polymorphism in cyclooxygenase-2 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Hepatitis, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12062631&form=6&db=m Role of Kupffer cells in alcoholic hepatitis. causal interaction,unassigned 3,0
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632332&form=6&db=m Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11001185&form=6&db=m Expression of cyclooxygenase mRNA in the livers of mice with interferon-gamma chronic hepatitis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12076714&form=6&db=m Expression of cyclooxygenase 2 and cytosolic phospholipase A(2) in the liver tissue of patients with chronic hepatitis and liver cirrhosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12201873&form=6&db=m Cyclooxygenase-2 mRNA is up-regulated in cirrhotic or chronic hepatitis liver adjacent to hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15055524&form=6&db=m The correlation between cyclooxygenase-2 expression and hepatocellular carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15377291&form=6&db=m Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17160481&form=6&db=m Cyclooxygenase-2 expression in hepatocellular carcinoma, cirrhosis and chronic hepatitis in the United States. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18601905&form=6&db=m COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250220&form=6&db=m Cyclooxygenase-2 expression in chronic liver diseases and hepatocellular carcinoma: an immunohistochemical study . causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21179273&form=6&db=m Increased expression of cyclooxygenase-2 is associated with the progression to cirrhosis. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23091809&form=6&db=m Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Hepatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26619541&form=6&db=m [The Expressions of Somatostatin and Cycloxygenase-2 in Chronic Hepatitis, Hepatic Cirrhosis, Precancerous Lesion and Hepatocellular Carcinoma]. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Hepatopulmonary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24986705&form=6&db=m Roles of cyclooxygenase 2 and hepatic venous flow in patients with HHT or hepatopulmonary syndrome. unassigned -
1.14.99.1 Hepatopulmonary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28632747&form=6&db=m Selective cyclooxygenase inhibition by SC-560 improves hepatopulmonary syndrome in cirrhotic rats. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Hepatopulmonary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28642034&form=6&db=m Cyclooxygenase-2 promotes pulmonary intravascular macrophage accumulation by exacerbating BMP signaling in rat experimental hepatopulmonary syndrome. ongoing research,unassigned 2,0
1.14.99.1 Hepatorenal Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3111964&form=6&db=m Immunohistochemical distribution of renal prostaglandin endoperoxide synthase and prostacyclin synthase: diminished endoperoxide synthase in the hepatorenal syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Herpes Genitalis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3526900&form=6&db=m Failure of ibuprofen in treatment of herpes genitalis. therapeutic application,unassigned 4,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119789&form=6&db=m The prophylactic use of cyclooxygenase inhibitors in recurrent herpes simplex infections. therapeutic application,unassigned 4,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509090&form=6&db=m Studies of phospholipase and cyclooxygenase activities in herpes simplex virus type 2-transformed rat cells. ongoing research,unassigned 4,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3026679&form=6&db=m Induction of cellular functions in spontaneously immortalized rat-2 cells transfected with cloned herpes simplex virus type 2 (HSV-2) DNA. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6956923&form=6&db=m Indomethacin enhancement of human natural killer cytotoxicity to herpes simplex virus infected cells in vitro and in vivo. unassigned -
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8510075&form=6&db=m Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781662&form=6&db=m Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15359292&form=6&db=m Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15542648&form=6&db=m Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15857277&form=6&db=m Inhibition of cyclooxygenase 2 synthesis suppresses Herpes simplex virus type 1 reactivation. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16841079&form=6&db=m The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18683705&form=6&db=m [Experimental study of suppression of reactivation of herpes simplex virus type 1 by cyclooxygenase 2 inhibitor with acyclovir] ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19571664&form=6&db=m Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20224909&form=6&db=m Inhibition of TNFalpha-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-kappaB- and MAPK-dependent mechanisms. therapeutic application,unassigned 1,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20577849&form=6&db=m Suppression of herpes simplex virus 1 reactivation in a mouse eye model by cyclooxygenase inhibitor, heat shock protein inhibitor, and adenosine monophosphate. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Herpes Simplex http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149863&form=6&db=m Molecular Targets and Mechanisms of Scutellariae radix-Coptidis rhizoma Drug Pair for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196446&form=6&db=m Role of arachidonic acid metabolism in ACTH-stimulated cortisol secretion by bovine adrenocortical cells. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14596828&form=6&db=m Characterization and application of Raman labels for confocal Raman microspectroscopic detection of cellular proteins in single cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30610879&form=6&db=m Vanillin protects the blood-milk barrier and inhibits the inflammatory response in LPS-induced mastitis in mice. causal interaction,unassigned 2,0
1.14.99.1 Herpes Zoster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33693730&form=6&db=m Trace amounts of antibiotic exacerbated diarrhea and systemic inflammation of weaned pigs infected with a pathogenic Escherichia coli. diagnostic usage,unassigned 1,0
1.14.99.1 Herpesviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16276519&form=6&db=m Gamma-herpesvirus neoplasia: a growing role for COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Herpesviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17006962&form=6&db=m Biological interactions between herpesviruses and cyclooxygenase enzymes. unassigned -
1.14.99.1 Herpesviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17467980&form=6&db=m Evidence of COX-1 and COX-2 expression in Kaposi's sarcoma tissues. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Histiocytic Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15872381&form=6&db=m Assessment of cyclooxygenase-2 expression in canine hemangiosarcoma, histiocytic sarcoma, and mast cell tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,3
1.14.99.1 Histiocytoma, Benign Fibrous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18201240&form=6&db=m Cyclooxygenase-2 expression in dermatofibroma and dermatofibrosarcoma protuberans. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Histiocytoma, Malignant Fibrous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981912&form=6&db=m A selective cyclooxygenase-2 inhibitor, NS-398, inhibits cell growth by cell cycle arrest in a human malignant fibrous histiocytoma cell line. ongoing research,unassigned 3,0
1.14.99.1 Histiocytoma, Malignant Fibrous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15375582&form=6&db=m Cyclooxygenase-2 in human malignant fibrous histiocytoma: correlations with intratumoral microvessel density, expression of vascular endothelial growth factor and thymidine phosphorylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10985260&form=6&db=m Induction of cyclooxygenase-2 expression during HIV-1-infected monocyte-derived macrophage and human brain microvascular endothelial cell interactions. causal interaction,unassigned 1,0
1.14.99.1 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16549964&form=6&db=m Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0
1.14.99.1 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21490090&form=6&db=m An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28480270&form=6&db=m A Randomized Placebo Controlled Trial of Aspirin Effects on Immune Activation in Chronically Human Immunodeficiency Virus-Infected Adults on Virologically Suppressive Antiretroviral Therapy. causal interaction,unassigned 4,0
1.14.99.1 HIV Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34509494&form=6&db=m ApoA-I mimetics favorably impact cyclooxygenase 2 and bioactive lipids that may contribute to cardiometabolic syndrome in chronic treated HIV. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3140669&form=6&db=m Expression of prostaglandin H synthase (cyclooxygenase) in Hodgkin's mononuclear and Reed-Sternberg cells. Functional resemblance between H-RS cells and histiocytes or interdigitating reticulum cells. causal interaction,unassigned 4,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3922613&form=6&db=m Normalization of monocyte candidacidal deficiency by cyclooxygenase inhibitors in Hodgkin's disease. causal interaction,unassigned 4,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17064999&form=6&db=m Expression of cyclooxygenase-2 in Hodgkin's lymphoma: its role in cell proliferation and angiogenesis. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691115&form=6&db=m Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20056623&form=6&db=m Aspirin and other nonsteroidal anti-inflammatory drugs in relation to Hodgkin lymphoma risk in northern Denmark. therapeutic application,unassigned 3,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346139&form=6&db=m Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22547578&form=6&db=m Expression of COX-2 on Reed-Sternberg cells is an independent unfavorable prognostic factor in Hodgkin lymphoma treated with ABVD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851330&form=6&db=m Prognostic significance of COX-2 expression and correlation with Bcl-2 and VEGF expression, microvessel density, and clinical variables in classical Hodgkin lymphoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24294363&form=6&db=m Epstein-Barr virus infection correlates with the expression of COX-2, p16(INK4A) and p53 in classic Hodgkin lymphoma. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25475251&form=6&db=m Radiation Therapy Overcomes Adverse Prognostic Role of Cyclooxygenase-2 Expression on Reed-Sternberg Cells in Early Hodgkin Lymphoma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26632465&form=6&db=m [Expression and prognostic value of COX- 2, p16(INK4A) and p53 in patients with classical Hodgkin lymphoma]. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Hodgkin Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31970686&form=6&db=m Cyclooxygenase-2 expression as a prognostic factor in pediatric classical Hodgkin lymphoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16940769&form=6&db=m Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Huntington Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483693&form=6&db=m Effects of the adenosine A2A receptor antagonist SCH 58621 on cyclooxygenase-2 expression, glial activation, and brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration. causal interaction,unassigned 4,0
1.14.99.1 Hydrocephalus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26463949&form=6&db=m Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hydrocephalus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30529453&form=6&db=m Temporal profile of serum mitochondrial DNA (mtDNA) in patients with aneurysmal subarachnoid hemorrhage (aSAH). therapeutic application,unassigned 1,0
1.14.99.1 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1177669&form=6&db=m Analyses of renal medullary lipid droplets from normal, hydronephrotic, and indomethacin treated rabbits. therapeutic application,unassigned 1,0
1.14.99.1 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3088262&form=6&db=m Eicosanoid synthesis by rabbit hydronephrotic cortical interstitial cells in culture. causal interaction,unassigned 3,0
1.14.99.1 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6433098&form=6&db=m Renal cortical drug and xenobiotic metabolism following urinary tract obstruction. unassigned -
1.14.99.1 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606429&form=6&db=m Critical role of cyclooxygenase-2 activation in pathogenesis of hydronephrosis caused by lactational exposure of mice to dioxin. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0
1.14.99.1 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18996358&form=6&db=m The significance of the nongenomic pathway in mediating inflammatory signaling of the dioxin-activated Ah receptor to cause toxic effects. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19782052&form=6&db=m TCDD-induced cyclooxygenase-2 expression is mediated by the nongenomic pathway in mouse MMDD1 macula densa cells and kidneys. unassigned -
1.14.99.1 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19797860&form=6&db=m Severe toxicity and cyclooxygenase (COX)-2 mRNA increase by lithium in the neonatal mouse kidney. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24509627&form=6&db=m Predominant role of cytosolic phospholipase A2? in dioxin-induced neonatal hydronephrosis in mice. causal interaction,unassigned 1,0
1.14.99.1 Hydronephrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25015655&form=6&db=m A mouse strain less responsive to dioxin-induced prostaglandin e2 synthesis is resistant to the onset of neonatal hydronephrosis. causal interaction,unassigned 3,0
1.14.99.1 Hydrops Fetalis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1560290&form=6&db=m Ductus-dependent fetal cardiac defects contraindicate indomethacin tocolysis. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Hydrops Fetalis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3078553&form=6&db=m Doppler echocardiography in the human fetus. therapeutic application,unassigned 2,0
1.14.99.1 Hyperaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6794401&form=6&db=m [Treatment of congenital chloride diarrhea with prostaglandin synthetase inhibitor (author's transl)] causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Hyperaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11673754&form=6&db=m Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide. therapeutic application,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1381521&form=6&db=m Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1534874&form=6&db=m Serotonin is a directly-acting hyperalgesic agent in the rat. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1594266&form=6&db=m Rat knee-joint carrageenin incapacitation test: an objective screen for central and peripheral analgesics. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1797337&form=6&db=m Interleukin-8 as a mediator of sympathetic pain. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1906235&form=6&db=m Analgetic activity of SK&F 105809, a dual inhibitor of arachidonic acid metabolism. ongoing research,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2546646&form=6&db=m Beta-estradiol induced catecholamine-sensitive hyperalgesia: a contribution to pain in Raynaud's phenomenon. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557557&form=6&db=m Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2767120&form=6&db=m Pharmacological characterization of the algesic response to the subplantar injection of serotonin in the rat. therapeutic application,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3100339&form=6&db=m Pathway to carrageenan-induced inflammation in the hind limb of the rat. therapeutic application,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3103625&form=6&db=m Pharmacological modulation of eicosanoid levels and hyperalgesia in yeast-induced inflammation. causal interaction,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7760984&form=6&db=m L-745,337: a selective inhibitor of cyclooxygenase-2 elicits antinociception but not gastric ulceration in rats. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8229782&form=6&db=m BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8317326&form=6&db=m Bradykinin release of TNF-alpha plays a key role in the development of inflammatory hyperalgesia. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8317344&form=6&db=m Spinal actions of NSAIDS in blocking spinally mediated hyperalgesia: the role of cyclooxygenase products. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8450973&form=6&db=m Mechanical hyperalgesia in streptozotocin-diabetic rats. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8577723&form=6&db=m Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8919832&form=6&db=m [Ketorolac for prevention of acute postoperative pain] causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930329&form=6&db=m Inhibition of peripheral interleukin-1 beta-induced hyperalgesia by the intracerebroventricular administration of diclofenac and alpha-melanocyte-stimulating hormone. causal interaction,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8945729&form=6&db=m Intracerebroventricular injection of tumor necrosis factor-alpha induces thermal hyperalgesia in rats. causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9000725&form=6&db=m Acute mechanical hyperalgesia in the rat can be produced by coactivation of spinal ionotropic AMPA and metabotropic glutamate receptors, activation of phospholipase A2 and generation of cyclooxygenase products. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9153662&form=6&db=m The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant-induced changes in hyperalgesia and allodynia. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9175123&form=6&db=m Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord. ongoing research,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9231865&form=6&db=m Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9243607&form=6&db=m Role of spinal cyclooxygenase (COX)-2 on thermal hyperalgesia evoked by carageenan injection in the rat. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9399978&form=6&db=m Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9618405&form=6&db=m Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9750013&form=6&db=m Effect of colchicine on nerve growth factor-induced leukocyte accumulation and thermal hyperalgesia in the rat. therapeutic application,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9789085&form=6&db=m Pharmacological analysis of cyclooxygenase-1 in inflammation. therapeutic application,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9866686&form=6&db=m Analysis of prostaglandin G/H synthase-2 inhibition using peroxidase-induced luminol luminescence. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9875720&form=6&db=m COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10208570&form=6&db=m N-methyl D-aspartate induced mechanical allodynia is blocked by nitric oxide synthase and cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10393880&form=6&db=m The spinal biology in humans and animals of pain states generated by persistent small afferent input. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10408970&form=6&db=m Thymulin induces c-fos expression in the spinal cord of rats which is reversed by meloxicam and morphine. ongoing research,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10422945&form=6&db=m Spinal antinociceptive effect of epidural nonsteroidal antiinflammatory drugs on nitric oxide-induced hyperalgesia in rats. therapeutic application,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10553835&form=6&db=m The role of the spinal opioid receptor like1 receptor, the NK-1 receptor, and cyclooxygenase-2 in maintaining postoperative pain in the rat. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10556918&form=6&db=m Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10764183&form=6&db=m Anti-allodynic effects of oral COX-2 selective inhibitor on postoperative pain in the rat. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807670&form=6&db=m Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10842019&form=6&db=m Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10954756&form=6&db=m Nociception in cyclooxygenase isozyme-deficient mice. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10964977&form=6&db=m Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11028754&form=6&db=m Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192259&form=6&db=m Cyclooxygenase-2 inhibitor SC-236 attenuates mechanical allodynia following nerve root injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11233998&form=6&db=m Resveratrol decreases hyperalgesia induced by carrageenan in the rat hind paw. ongoing research,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11260714&form=6&db=m Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11268335&form=6&db=m Hypothalamic mechanisms of pain modulatory actions of cytokines and prostaglandin E2. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11275357&form=6&db=m Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11376908&form=6&db=m Topical bicuculline to the rat spinal cord induces highly localized allodynia that is mediated by spinal prostaglandins. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11409492&form=6&db=m Participation of cyclooxygenases in cutaneous thermal nociception under non-inflamed and inflamed conditions. causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11433347&form=6&db=m Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11487607&form=6&db=m The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. therapeutic application,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11597589&form=6&db=m Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11846620&form=6&db=m Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. ongoing research,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11918320&form=6&db=m Epidural injection of cyclooxygenase-2 inhibitor attenuates pain-related behavior following application of nucleus pulposus to the nerve root in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020867&form=6&db=m Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086957&form=6&db=m Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12176025&form=6&db=m Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2. therapeutic application,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12373690&form=6&db=m Cyclooxygenase-2 inhibition potentiates morphine antinociception at the spinal level in a postoperative pain model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12411415&form=6&db=m Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12467993&form=6&db=m Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12489814&form=6&db=m Role of kinin and prostaglandin in cutaneous thermal nociception. causal interaction,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12502994&form=6&db=m Transient up-regulation of spinal cyclooxygenase-2 and neuronal nitric oxide synthase following surgical inflammation. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12855310&form=6&db=m Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871573&form=6&db=m Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12877584&form=6&db=m Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552899&form=6&db=m Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation. causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14568028&form=6&db=m Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14568029&form=6&db=m Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575647&form=6&db=m Cyclooxygenases in the skin: pharmacological and toxicological implications. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576557&form=6&db=m Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597606&form=6&db=m Pharmacological characterisation of a rat model of incisional pain. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14624058&form=6&db=m Modulatory effect of cyclooxygenase inhibitors on sildenafil-induced antinociception. ongoing research,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14625016&form=6&db=m Central cyclooxygenase-2 participates in interleukin-1 beta-induced hyperalgesia in the orofacial formalin test of freely moving rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14697327&form=6&db=m Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715386&form=6&db=m Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14746896&form=6&db=m Peri-sciatic administration of indomethacin early after nerve injury can attenuate the development of tactile allodynia in a rat model of L5 single spinal nerve injury. ongoing research,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14960618&form=6&db=m Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026129&form=6&db=m Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15028765&form=6&db=m Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15035779&form=6&db=m Effect of selective inhibition of cyclooxygenase-2 on lipopolysaccharide-induced hyperalgesia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044444&form=6&db=m Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15109518&form=6&db=m The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15140630&form=6&db=m Pharmacological characterization of the chronic constriction injury model of neuropathic pain. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15175421&form=6&db=m Intrathecal protease-activated receptor stimulation produces thermal hyperalgesia through spinal cyclooxygenase activity. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15219259&form=6&db=m Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15235822&form=6&db=m Cyclooxygenase inhibitors and thalidomide ameliorate vincristine-induced hyperalgesia in rats. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15265319&form=6&db=m Effect of zileuton in radicular pain induced by herniated nucleus pulposus in rats. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15276874&form=6&db=m Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain. therapeutic application,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15328037&form=6&db=m Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom. therapeutic application,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15464832&form=6&db=m Prevention by celecoxib of secondary hyperalgesia induced by formalin in rats. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501196&form=6&db=m Spinal neural cyclooxygenase-2 mediates pain caused in a rat model of lumbar disk herniation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15560114&form=6&db=m Nociception and the differential expression of cyclooxygenase-1 (COX-1), the COX-1 variant retaining intron-1 (COX-1v), and COX-2 in mouse dorsal root ganglia (DRG). causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15627439&form=6&db=m R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models. therapeutic application,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661439&form=6&db=m Rofecoxib attenuates both primary and secondary inflammatory hyperalgesia: a randomized, double blinded, placebo controlled crossover trial in the UV-B pain model. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685208&form=6&db=m Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. causal interaction,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15691066&form=6&db=m Role of cyclooxygenase-2 in lipopolysaccharide-induced hyperalgesia in formalin test. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15799002&form=6&db=m Reversal of LPS-induced central and peripheral hyperalgesia by green tea extract. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15925144&form=6&db=m Intracisternal administration of chemokines facilitated formalin-induced behavioral responses in the orofacial area of freely moving rats. therapeutic application,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15942684&form=6&db=m The anti-inflammatory effects of 2 Hz electroacupuncture with different intensities on acute carrageenan-induced inflammation in the rat paw. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16032587&form=6&db=m Systemic meloxicam reduces tactile allodynia development after L5 single spinal nerve injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16098663&form=6&db=m Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16176831&form=6&db=m Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16182319&form=6&db=m Analysis of interaction between etoricoxib and tramadol against mechanical hyperalgesia of spinal cord injury in rats. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16297551&form=6&db=m Neonatal immune challenge alters nociception in the adult rat. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16298092&form=6&db=m Probable role of spinal purinoceptors in the analgesic effect of Trigonella foenum (TFG) leaves extract. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16310374&form=6&db=m Nitric oxide reverses endotoxin-induced inflammatory hyperalgesia via inhibition of prostacyclin production in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16448396&form=6&db=m Anti-inflammatory effect of licofelone against various inflammatory challenges. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16529650&form=6&db=m Effect of valdecoxib pretreatment on pain and secondary hyperalgesia: a randomized controlled trial in healthy volunteers [ISRCTN05282752,NCT00260325]. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16556900&form=6&db=m Sex differences in inflammation and inflammatory pain in cyclooxygenase-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16580130&form=6&db=m The long-term exposure of rat cultured dorsal root ganglion cells to bradykinin induced the release of prostaglandin E2 by the activation of cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16620880&form=6&db=m Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16837162&form=6&db=m Selective cyclooxygenase inhibition: its role in pain and anaesthesia. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949875&form=6&db=m Peripheral formalin injection induces long-lasting increases in cyclooxygenase 1 expression by microglia in the spinal cord. causal interaction,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17055166&form=6&db=m GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17112505&form=6&db=m Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17163587&form=6&db=m Electroacupuncture inhibits inflammatory edema and hyperalgesia through regulation of cyclooxygenase synthesis in both peripheral and central nociceptive sites. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17189672&form=6&db=m Pharmacological and histopathological characterization of a hyperalgesia model induced by freeze lesion. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17217946&form=6&db=m Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17257768&form=6&db=m 5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue. therapeutic application,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17287466&form=6&db=m Pathogenesis of spinally mediated hyperalgesia in diabetes. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17303338&form=6&db=m Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17400291&form=6&db=m Bradykinin into amygdala induces thermal hyperalgesia in rats. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413918&form=6&db=m Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17622776&form=6&db=m Postoperative administration of the analgesic tramadol, but not the selective cyclooxygenase-2 inhibitor parecoxib, abolishes postoperative hyperalgesia in a new model of postoperative pain in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17716650&form=6&db=m Mathematical analysis of involvement ratio between central and peripheral COX-2 in rat pain models with two types of COX-2 inhibitors with different distribution, celecoxib and CIAA. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17989504&form=6&db=m Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18028337&form=6&db=m Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors. causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18262365&form=6&db=m Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18297109&form=6&db=m Prostaglandin E(2) glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkappaB activity. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18333963&form=6&db=m Sensitization of meningeal nociceptors: inhibition by naproxen. therapeutic application,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18349208&form=6&db=m Upregulation of dorsal horn microglial cyclooxygenase-1 and neuronal cyclooxygenase-2 after thoracic deep muscle incisions in the rat. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18419601&form=6&db=m Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice. causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18440503&form=6&db=m Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase. ongoing research,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18497304&form=6&db=m Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. therapeutic application,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617333&form=6&db=m Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18721668&form=6&db=m Synergistic anti-hyperalgesia of electroacupuncture and low dose of celecoxib in monoarthritic rats: involvement of the cyclooxygenase activity in the spinal cord. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18814970&form=6&db=m Antinociceptive effect of resveratrol in carrageenan-evoked hyperalgesia in rats: prolonged effect related to COX-2 expression impairment. ongoing research,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18829279&form=6&db=m COX-2 expression and function in the hyperalgesic response to paw inflammation in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19059783&form=6&db=m Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo[1,2-a]pyridine symbiotic prototypes. ongoing research,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19066421&form=6&db=m Effect of cyclooxygenase and nitric oxide synthase inhibitors on vincristine induced hyperalgesia in rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19066982&form=6&db=m [Modulation of cortical pain processing by cyclooxygenase inhibition : A functional MRI study.] causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19068510&form=6&db=m Migraine, allodynia, and implications for treatment. therapeutic application,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19091963&form=6&db=m Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19135800&form=6&db=m Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19231080&form=6&db=m Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase-2 signalling. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239920&form=6&db=m Intracisternal administration of COX inhibitors attenuates mechanical allodynia following compression of the trigeminal ganglion in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19346674&form=6&db=m Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19663884&form=6&db=m Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats. ongoing research,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19690271&form=6&db=m The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19815945&form=6&db=m Bradykinin receptor antagonists and cyclooxygenase inhibitors in vincristine- and streptozotocin-induced hyperalgesia. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20134354&form=6&db=m Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression. causal interaction,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20450958&form=6&db=m Cyclooxygenase inhibitors suppress the expression of P2X(3) receptors in the DRG and attenuate hyperalgesia following chronic constriction injury in rats. causal interaction,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21192429&form=6&db=m [Changes of COX-2 expression in the dorsal horn of the spinal cord during formalin-induced inflammatory pain and hyperalgesia in rats]. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21396775&form=6&db=m Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21396778&form=6&db=m ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. causal interaction,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21551240&form=6&db=m Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-{kappa}B- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22112635&form=6&db=m Co-induction of cyclooxyenase-2 and early growth response gene (Egr-1) in spinal cord in a clinical model of persistent inflammation and hyperalgesia. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22198006&form=6&db=m Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats. ongoing research,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22402211&form=6&db=m Therapeutic potential of andrographolide for treating endometriosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460833&form=6&db=m Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22581285&form=6&db=m Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22739568&form=6&db=m Etodolac Blocks the Allyl Isothiocyanate-Induced Response in Mouse Sensory Neurons by Selective TRPA1 Activation. therapeutic application,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22823006&form=6&db=m The pre-emptive analgesic effect of a cyclooxygenase-2 inhibitor in a rat model of acute postoperative pain. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23018204&form=6&db=m Modification of rat model of sciatica induced by lumber disc herniation and the anti-inflammatory effect of osthole given by epidural catheterization. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23347081&form=6&db=m Interleukin-33/ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain: role of cytokines, endothelin-1 and prostaglandin E(2). ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401543&form=6&db=m Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23505121&form=6&db=m COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23521647&form=6&db=m Mechanisms underlying transient receptor potential ankyrin 1 (TRPA1)-mediated hyperalgesia and edema. therapeutic application,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23587883&form=6&db=m Upregulated glial cell line-derived neurotrophic factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23683582&form=6&db=m The molecular link between C-C-chemokine ligand 2-induced leukocyte recruitment and hyperalgesia. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23799042&form=6&db=m TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23929706&form=6&db=m Progesterone reduces the expression of spinal cyclooxygenase-2 and inducible nitric oxide synthase and prevents allodynia in a rat model of central neuropathic pain. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073414&form=6&db=m The ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24532118&form=6&db=m Low-level laser therapy (LLLT) reduces the COX-2 mRNA expression in both subplantar and total brain tissues in the model of peripheral inflammation induced by administration of carrageenan. causal interaction,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24657450&form=6&db=m The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity. therapeutic application,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24722146&form=6&db=m Antinociceptive Effect of Tetrandrine on LPS-Induced Hyperalgesia via the Inhibition of IKK? Phosphorylation and the COX-2/PGE2 Pathway in Mice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24852102&form=6&db=m Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24905509&form=6&db=m Pharmacological characterization of carrageenan induced heat muscle hyperalgesia in rats using non-selective, preferential and selective COX-2 inhibitors. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24997266&form=6&db=m Peripheral P2X7 receptor-induced mechanical hyperalgesia is mediated by bradykinin. therapeutic application,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25017240&form=6&db=m Hyperalgesic and edematogenic effects of Secapin-2, a peptide isolated from Africanized honeybee (Apis mellifera) venom. diagnostic usage,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25446353&form=6&db=m Muscle hyperalgesia induced by peripheral P2X3 receptors is modulated by inflammatory mediators. therapeutic application,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25599304&form=6&db=m Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25714890&form=6&db=m The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2. ongoing research,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25858171&form=6&db=m Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury-Induced Lumbar Facet Joint Osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25919495&form=6&db=m COX-2 is required for the modulation of spinal nociceptive information related to ephrinB/EphB signalling. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808144&form=6&db=m Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26938560&form=6&db=m Paulistine-The Functional Duality of a Wasp Venom Peptide Toxin. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27068286&form=6&db=m Resveratrol attenuates inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis neurons associated with hyperalgesia in rats. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27121041&form=6&db=m Nutmeg oil alleviates chronic inflammatory pain through inhibition of COX-2 expression and substance P release in vivo. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27518488&form=6&db=m Preoperative but Not Postoperative Flurbiprofen Axetil Alleviates Remifentanil Induced Hyperalgesia after Laparoscopic Gynecological Surgery: A Prospective, Randomized, Double-blinded, Trial. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27743933&form=6&db=m Contribution of large-sized primary sensory neuronal sensitization to mechanical allodynia by upregulation of hyperpolarization-activated cyclic nucleotide gated channels via cyclooxygenase 1 cascade. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27821910&form=6&db=m Celecoxib alleviates oxaliplatin-induced hyperalgesia through inhibition of spinal ERK1/2 signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27861574&form=6&db=m Cyclooxygenase Isoform Exchange Blocks Brain-Mediated Inflammatory Symptoms. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27871576&form=6&db=m Influence of high-dose intraoperative remifentanil with intravenous ibuprofen on postoperative morphine consumption in patients undergoing pancreaticoduodenectomy: a randomized trial. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27935990&form=6&db=m Hyperalgesia and Persistent Pain after Breast Cancer Surgery: A Prospective Randomized Controlled Trial with Perioperative COX-2 Inhibition. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28126501&form=6&db=m Hyperalgesic and hypoalgesic mechanisms evoked by the acute administration of CCL5 in mice. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28344594&form=6&db=m Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28389633&form=6&db=m Leonurine Attenuates Hyperalgesia in Mice with Induced Adenomyosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28589150&form=6&db=m Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice. ongoing research,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759126&form=6&db=m EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28778815&form=6&db=m Fourteen days of etoricoxib 60 mg improves pain, hyperalgesia and physical function in individuals with knee osteoarthritis: a randomized controlled trial. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29576123&form=6&db=m Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29736690&form=6&db=m Osthole ameliorates neurogenic and inflammatory hyperalgesia by modulation of iNOS, COX-2, and inflammatory cytokines in mice. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29913996&form=6&db=m The attenuation of pain behaviour and serum interleukin-6 concentration by nimesulide in a rat model of neuropathic pain. therapeutic application,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29990699&form=6&db=m Neutrophils contribute to the pathogenesis of hemorrhagic cystitis induced by ifosfamide. unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30130298&form=6&db=m Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30262747&form=6&db=m Systemic Lipopolysaccharide-Induced Pain Sensitivity and Spinal Inflammation Were Reduced by Minocycline in Neonatal Rats. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30498399&form=6&db=m Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration of lutein via inhibition of cyclooxygenase-2 cascade signaling. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30528878&form=6&db=m Bradykinin and interleukin-1? synergistically increase the expression of cyclooxygenase-2 through the RNA-binding protein HuR in rat dorsal root ganglion cells. causal interaction,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30759061&form=6&db=m COX-2 contributed to the remifentanil-induced hyperalgesia related to ephrinB/EphB signaling. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30796025&form=6&db=m Sensitization of nociceptors by prostaglandin E2-glycerol contributes to hyperalgesia in mice with sickle cell disease. causal interaction,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118754&form=6&db=m Mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31306980&form=6&db=m Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31547612&form=6&db=m Effects of Extract of Arrabidaea chica Verlot on an Experimental Model of Osteoarthritis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31693705&form=6&db=m Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31758266&form=6&db=m Nocebo and the contribution of psychosocial factors to the generation of pain. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31843462&form=6&db=m Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats. causal interaction,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920306&form=6&db=m Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain. causal interaction,unassigned 3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31987865&form=6&db=m Interleukin-1 receptor antagonist ameliorates the pain hypersensitivity, spinal inflammation and oxidative stress induced by systemic lipopolysaccharide in neonatal rats. therapeutic application,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32092837&form=6&db=m Dragon's Blood Inhibits Chronic Inflammatory and Neuropathic Pain Responses by Blocking the Synthesis and Release of Substance P in Rats. ongoing research,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32145326&form=6&db=m P2X3 and P2X2/3 receptors activation induces articular hyperalgesia by an indirect sensitization of the primary afferent nociceptor in the rats' knee joint. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32348427&form=6&db=m Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32478188&form=6&db=m Mechanism of aspirin-induced inhibition on the secondary hyperalgesia in osteoarthritis model rats. therapeutic application,unassigned 4,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32557241&form=6&db=m TRPV1, Targeted by miR-338-3p, Induces Neuropathic Pain by Interacting with NECAB2. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32738748&form=6&db=m Laser-photobiomodulation on experimental cancer pain model in Walker Tumor-256. ongoing research,unassigned 1,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973194&form=6&db=m The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33012515&form=6&db=m Corrigendum to 'Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats' (Br J Anaesth 2018; 120: 827-35). unassigned -
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33145614&form=6&db=m Role of central endothelin-1 in hyperalgesia, anhedonia, and hypolocomotion induced by endotoxin in male rats. therapeutic application,unassigned 2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33259823&form=6&db=m Inflammatory mediators in the pronociceptive effects induced by Bothrops leucurus snake venom: The role of biogenic amines, nitric oxide, and eicosanoids. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33339104&form=6&db=m Protective Effect of Antioxidants in Nitric Oxide/COX-2 Interaction during Inflammatory Pain: The Role of Nitration. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Hyperalgesia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33908261&form=6&db=m An opioid receptor-independent mechanism underlies motility dysfunction and visceral hyperalgesia in opioid-induced bowel dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Hypercalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3003159&form=6&db=m Humoral hypercalcemia of malignancy. Release of a prostaglandin-stimulating bone-resorbing factor in vitro by human transitional-cell carcinoma cells. causal interaction,unassigned 1,0
1.14.99.1 Hypercalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6281603&form=6&db=m Hypercalcemia in association with a Leydig cell tumor in the rat: a model for tumor-induced hypercalcemia in man. therapeutic application,unassigned 2,0
1.14.99.1 Hypercalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9329957&form=6&db=m Hypercalcemia stimulates expression of intrarenal phospholipase A2 and prostaglandin H synthase-2 in rats. Role of angiotensin II AT1 receptors. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Hypercalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12512690&form=6&db=m The eicosanoid factor: a determinant of individuality of nephron segments. causal interaction,unassigned 4,0
1.14.99.1 Hypercalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14711936&form=6&db=m Inhibition of cyclooxygenase-2 by celecoxib reverses tumor-induced wasting. therapeutic application,unassigned 4,0
1.14.99.1 Hypercalcemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22800939&form=6&db=m Tumor necrosis factor-alpha induces renal cyclooxygenase-2 expression in response to hypercalcemia. ongoing research,unassigned 4,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1887929&form=6&db=m Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. therapeutic application,unassigned 2,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9817373&form=6&db=m Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15972451&form=6&db=m In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415485&form=6&db=m Aspirin resistance. unassigned -
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17626122&form=6&db=m Altered mechanisms of endothelium-dependent dilation in skeletal muscle arterioles with genetic hypercholesterolemia. unassigned -
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17933963&form=6&db=m Roles of platelet and endothelial cell COX-1 in hypercholesterolemia-induced microvascular dysfunction. ongoing research,unassigned 1,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19361808&form=6&db=m Gene Transfer of COX-1 Improves Lumen Size and Blood Flow in Carotid Bypass Grafts. ongoing research,unassigned 2,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19783781&form=6&db=m Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21621186&form=6&db=m Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids. causal interaction,unassigned 2,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21762932&form=6&db=m Hypercholesterolemia and chronic ischemia alter myocardial responses to selective cyclooxygenase-2 inhibition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22168377&form=6&db=m Celecoxib, a selective cyclooxygenase-2 inhibitor, lowers plasma cholesterol and attenuates hepatic lipid peroxidation during carbon-tetrachloride-associated hepatotoxicity in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24856376&form=6&db=m Cyclooxygenase-2 inhibition improves antioxidative defense during experimental hypercholesterolemia. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypercholesterolemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26084115&form=6&db=m Hypolipidemic effects of nimesulide and celecoxib in experimentally induced hypercholesterolemia in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=106313&form=6&db=m Pyrogenic renal hyperemia: the role of prostaglandins. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=517656&form=6&db=m Bradykinin-induced renal hemodynamic alterations: renin and prostaglandin relationships. causal interaction,unassigned 3,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=805795&form=6&db=m Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart. therapeutic application,unassigned 2,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1282960&form=6&db=m Functional hyperemia of skeletal muscle: role of endothelium. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1686771&form=6&db=m [The participation of humoral factors released by the endothelium in the development of reactive hyperemia] causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1767845&form=6&db=m Mechanism of aggravation of mucosal injury by intravenous nicotine in rat stomach. therapeutic application,unassigned 1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2396508&form=6&db=m Indomethacin attenuates early postischemic vasogenic edema and cerebral injury. causal interaction,unassigned 3,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3931484&form=6&db=m Differential effect of cyclooxygenase inhibitors on absorptive hyperemia. therapeutic application,unassigned 3,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3965697&form=6&db=m Inhibitory effect of quinacrine on myocardial reactive hyperemia in the dog. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7065141&form=6&db=m Prostaglandin synthesis inhibition and postprandial intestinal hyperemia. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7516628&form=6&db=m Nitric oxide and prostanoids contribute to isoflurane-induced cerebral hyperemia in pigs. therapeutic application,unassigned 1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8508526&form=6&db=m Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans. causal interaction,unassigned 1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8650250&form=6&db=m Relationship between opioids and prostaglandins in hypoxia-induced vasodilation of pial arteries in the newborn pig. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8756014&form=6&db=m Coronary and systemic hemodynamic effects of sustained inhibition of nitric oxide synthesis in conscious dogs. Evidence for cross talk between nitric oxide and cyclooxygenase in coronary vessels. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8904603&form=6&db=m Contribution of nitric oxide and prostaglandins to reactive hyperemia in human forearm. therapeutic application,unassigned 1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9296338&form=6&db=m Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts. therapeutic application,unassigned 1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9330129&form=6&db=m Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9626296&form=6&db=m Role of inducible nitric oxide synthase and cyclooxygenase-2 in endotoxin-induced cerebral hyperemia. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10028935&form=6&db=m Effects of antiaggregant and antiinflammatory doses of aspirin on coronary hemodynamics and myocardial reactive hyperemia in conscious dogs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632605&form=6&db=m Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. causal interaction,unassigned 1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11004044&form=6&db=m Endotoxin augments cerebral hyperemic response to halothane by inducing nitric oxide synthase and cyclooxygenase. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11820457&form=6&db=m Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871756&form=6&db=m Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15247159&form=6&db=m Local heating of human skin causes hyperemia without mediation by muscarinic cholinergic receptors or prostanoids. unassigned -
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15453089&form=6&db=m Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. therapeutic application,unassigned 1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16388306&form=6&db=m Astrocyte-mediated control of cerebral blood flow. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369458&form=6&db=m Cyclooxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18579080&form=6&db=m Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19904289&form=6&db=m Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats. therapeutic application,unassigned 1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24706194&form=6&db=m The Effect of Aging and Indomethacin on Forearm Reactive Hyperemia in Healthy Adults. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25774496&form=6&db=m Endogenous prostaglandins and afferent sensory nerves in gastroprotective effect of hydrogen sulfide against stress-induced gastric lesions. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hyperemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212299&form=6&db=m Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations. therapeutic application,unassigned 2,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9880398&form=6&db=m Spreading depression-induced gene expression is regulated by plasma glucose. unassigned -
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10102698&form=6&db=m Developmental damage, increased lipid peroxidation, diminished cyclooxygenase-2 gene expression, and lowered prostaglandin E2 levels in rat embryos exposed to a diabetic environment. diagnostic usage,unassigned 3,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12732344&form=6&db=m Elevated glucose blocks angiotensin-(1-7) and bradykinin interaction: the role of cyclooxygenase products. causal interaction,unassigned 3,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14514642&form=6&db=m Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14749287&form=6&db=m Glucose-induced regulation of COX-2 expression in human islets of Langerhans. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15213311&form=6&db=m Activation of phosphoinositide 3-kinase in response to high glucose leads to regulation of reactive oxygen species-related nuclear factor-kappaB activation and cyclooxygenase-2 expression in mesangial cells. unassigned -
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15371279&form=6&db=m Interaction between NO and COX pathways in retinal cells exposed to elevated glucose and retina of diabetic rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15737438&form=6&db=m Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15967162&form=6&db=m Atorvastatin reduces the plasma lipids and oxidative stress but did not reverse the inhibition of prostacyclin generation by aortas in streptozotocin diabetic rats. diagnostic usage,unassigned 3,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16043871&form=6&db=m Drug intervention can correct subnormal retinal oxygenation response in experimental diabetic retinopathy. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16880625&form=6&db=m Protective effect of sun ginseng against diabetic renal damage. causal interaction,unassigned 2,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17595242&form=6&db=m Gene expression in peripheral blood mononuclear cells from children with diabetes. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17720896&form=6&db=m Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes. ongoing research,unassigned 4,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17825788&form=6&db=m Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974130&form=6&db=m Indomethacin inhibits thymic involution in mice with streptozotocin-induced diabetes. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19012035&form=6&db=m Mechanisms of pancreatic fibrosis and applications to the treatment of chronic pancreatitis. causal interaction,unassigned 3,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19060127&form=6&db=m Effects of cyclooxygenase-2 gene inactivation on cardiac autonomic and left ventricular function in experimental diabetes. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20299485&form=6&db=m HYPERGLYCEMIA-INDUCED PLATELET ACTIVATION IN TYPE 2 DIABETES MELLITUS IS RESISTANT TO ASPIRIN BUT NOT TO A NITRIC OXIDE-DONATING AGENT. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20427716&form=6&db=m Mechanisms of Burn-induced Impairment in Gastric Slow Waves and Emptying in Rats. therapeutic application,unassigned 1,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21414430&form=6&db=m Benzylamine and methylamine, substrates of semicarbazide-sensitive amine oxidase, attenuate inflammatory response induced by lipopolysaccharide. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21737546&form=6&db=m Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23059845&form=6&db=m Cyclooxygenase-2 over-expression inhibits liver apoptosis induced by hyperglycemia. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23817085&form=6&db=m Chronic administration of EP4-selective agonist exacerbates albuminuria and fibrosis of the kidney in streptozotocin-induced diabetic mice through IL-6. causal interaction,unassigned 3,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27788294&form=6&db=m Streptozotocin-Induced Maternal Hyperglycemia Increases the Expression of Antioxidant Enzymes and Mast Cell Number in Offspring Rat Ventral Prostate. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29739827&form=6&db=m Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice. therapeutic application,unassigned 4,0
1.14.99.1 Hyperhidrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23379606&form=6&db=m Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier. causal interaction,unassigned 4,0
1.14.99.1 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19615686&form=6&db=m Cyclooxygenase-2 derived thromboxane A(2) and reactive oxygen species mediate flow-induced constrictions of venules in hyperhomocysteinemia. unassigned -
1.14.99.1 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19657099&form=6&db=m Induction of hepatic cyclooxygenase-2 by hyperhomocysteinemia via nuclear factor-kappaB activation. ongoing research,unassigned 4,0
1.14.99.1 Hyperhomocysteinemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29413962&form=6&db=m Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis. causal interaction,unassigned 3,0
1.14.99.1 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2040360&form=6&db=m Indomethacin reverses interleukin-1-induced hyperinsulinemia in conscious and freely moving rats. ongoing research,unassigned 4,0
1.14.99.1 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2572177&form=6&db=m Central interleukin 1-elicited hyperinsulinemia is mediated by prostaglandins but not autonomics. therapeutic application,unassigned 1,0
1.14.99.1 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14757778&form=6&db=m Androgens are necessary for the development of fructose-induced hypertension. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15882258&form=6&db=m Renal cyclooxygenase-2 in obese Zucker (fatty) rats. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Hyperinsulinism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26188590&form=6&db=m Fructose-induced inflammation, insulin resistance and oxidative stress: A liver pathological triad effectively disrupted by lipoic acid. ongoing research,unassigned 1,0
1.14.99.1 Hyperkalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8993246&form=6&db=m Hyperkalemia exposure impairs EDHF-mediated endothelial function in the human coronary artery. causal interaction,unassigned 4,0
1.14.99.1 Hyperkalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11102561&form=6&db=m COX-2 and the kidneys. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Hyperkalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12113843&form=6&db=m Fatal hyperkalemia related to combined therapy with a COX-2 inhibitor, ACE inhibitor and potassium rich diet. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Hyperkalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18042395&form=6&db=m Adenosine instead of supranormal potassium in cardioplegic solution preserves endothelium-derived hyperpolarization factor-dependent vasodilation. causal interaction,unassigned 2,0
1.14.99.1 Hyperkalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20842761&form=6&db=m Risk of hyperkalemia associated with selective COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hyperkalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21373319&form=6&db=m Etoricoxib-induced life-threatening hyperkalemia and acute kidney dysfunction against the background of telmisartan and a low sodium diet. unassigned -
1.14.99.1 Hyperkalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22503390&form=6&db=m Dispensed selective and nonselective nonsteroidal anti-inflammatory drugs and the risk of moderate to severe hyperkalemia: a nested case-control study. therapeutic application,unassigned 3,0
1.14.99.1 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6803387&form=6&db=m The role of platelet hyperfunction in thrombus formation in hyperlipidemia. diagnostic usage,unassigned 1,0
1.14.99.1 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18373278&form=6&db=m Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma. ongoing research,unassigned 4,0
1.14.99.1 Hyperlipidemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25727911&form=6&db=m Downregulation of miR-146a, cyclooxygenase-2 and advanced glycation end-products in simvastatin-treated older patients with hyperlipidemia. diagnostic usage,unassigned 3,0
1.14.99.1 Hyperlipoproteinemia Type II http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679712&form=6&db=m Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Hyperostosis, Cortical, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6808107&form=6&db=m Prostaglandin synthetase inhibitor in Caffey disease. unassigned -
1.14.99.1 Hyperoxaluria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16311770&form=6&db=m An animal model of calcium oxalate urolithiasis based on a cyclooxygenase 2 selective inhibitor. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperparathyroidism, Primary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625247&form=6&db=m Do cyclooxygenase-2 knockout mice have primary hyperparathyroidism? causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Hyperparathyroidism, Secondary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20471507&form=6&db=m Basal bone phenotype and increased anabolic responses to intermittent parathyroid hormone in healthy male COX-2 knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Hyperpigmentation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22506937&form=6&db=m siRNA-mediated knock-down of COX-2 in melanocytes suppresses melanogenesis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Hyperpigmentation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26287130&form=6&db=m Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1594266&form=6&db=m Rat knee-joint carrageenin incapacitation test: an objective screen for central and peripheral analgesics. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2554671&form=6&db=m [Effect of tolmetin on responsiveness of isolated guinea pig tracheal smooth muscles] unassigned -
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2676276&form=6&db=m New concepts in the pathogenesis of asthma. causal interaction,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6404261&form=6&db=m Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6430962&form=6&db=m Role of lipoxygenase products in murine pulmonary granuloma formation. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6715724&form=6&db=m Effect of flurbiprofen, a cyclooxygenase inhibiting drug, on induced allergic rhinitis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7316107&form=6&db=m Idiosyncrasy to pyrazolone drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7732868&form=6&db=m Cyclooxygenase in rat pleural hypersensitivity reactions. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7758154&form=6&db=m Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7897158&form=6&db=m Products of arachidonic acid metabolism and the effects of cyclooxygenase inhibition on ongoing cutaneous allergic reactions in human beings. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8838113&form=6&db=m [Molecular pharmacology and application to the bronchial asthma of thromboxane A2 antagonists] causal interaction,unassigned 1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8876937&form=6&db=m Pharmacologic modulation of delayed-type hypersensitivity in mice. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10426495&form=6&db=m Restricted cyclooxygenase-2 expression in the central nervous system following acute and delayed-type hypersensitivity responses to bacillus Calmette-Guérin. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11260714&form=6&db=m Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11900314&form=6&db=m Identification of sulfonamide-like adverse drug reactions to celecoxib in the World Health Organization database. therapeutic application,unassigned 3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020867&form=6&db=m Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12517731&form=6&db=m Cytokine-induced neutrophil chemoattractant 1 (CINC-1) mediates the sympathetic component of inflammatory mechanical hypersensitivitiy in rats. therapeutic application,unassigned 1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12816152&form=6&db=m Intolerance reactions due to the selective cyclooxygenase type II inhibitors rofecoxib and celecoxib. Results of oral provocation tests in patients with NSAID hypersensitivity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12974196&form=6&db=m Safe full-dose one-step nabumetone challenge in patients with nonsteroidal anti-inflammatory drug hypersensitivity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14519044&form=6&db=m Safety of COX-2 inhibitors in asthma patients with aspirin hypersensitivity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217394&form=6&db=m Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15363658&form=6&db=m Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501312&form=6&db=m Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15587760&form=6&db=m Combination treatment using the COX-2 inhibitor meloxicam and an anti-allergic in pollinosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15590261&form=6&db=m Treatment of refractory mesenteric traction syndrome without cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661447&form=6&db=m Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats. causal interaction,unassigned 2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767031&form=6&db=m Cross-reactivity among drugs: clinical problems. therapeutic application,unassigned 3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15997464&form=6&db=m Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16006273&form=6&db=m Aspirin resistance: an evaluation of current evidence and measurement methods. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16079499&form=6&db=m Development of an in vivo bioassay method for allergy-preventive substances using hen-egg white lysozyme (HEL)-induced blood flow decrease. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16122956&form=6&db=m Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16297551&form=6&db=m Neonatal immune challenge alters nociception in the adult rat. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16457808&form=6&db=m The broken balance in aspirin hypersensitivity. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508388&form=6&db=m Developmental Differences in Spinal Cyclooxygenase 1 Expression after Surgical Incision. therapeutic application,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740361&form=6&db=m Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats. ongoing research,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16931682&form=6&db=m Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. therapeutic application,unassigned 3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016059&form=6&db=m Safety of meloxicam in aspirin-hypersensitive patients with asthma and/or nasal polyps. A challenge-proven study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17055166&form=6&db=m GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17065897&form=6&db=m Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17228166&form=6&db=m Etoricoxib tolerability in patients with hypersensitivity to nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17304885&form=6&db=m Tolerance to etoricoxib in 37 patients with urticaria and angioedema induced by nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890764&form=6&db=m Dermal exposure to jet fuel suppresses delayed-type hypersensitivity: a critical role for aromatic hydrocarbons. causal interaction,unassigned 1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006935&form=6&db=m An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18315734&form=6&db=m Comparison of expression profiles induced by dust mite in airway epithelia reveals a common pathway. causal interaction,unassigned 1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336751&form=6&db=m Parecoxib as an alternative in COX-2 hypersensitivity. therapeutic application,unassigned 1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18414395&form=6&db=m Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats. causal interaction,unassigned 3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606213&form=6&db=m Electroacupuncture inhibits cyclooxygenase-2 up-regulation in rat spinal cord after spinal nerve ligation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18693161&form=6&db=m Hypersensitivity to cyclooxygenase inhibitory drugs in children: a study of 164 cases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18842291&form=6&db=m Clinical course and urinary eicosanoids in patients with aspirin-induced urticaria followed up for 4 years. therapeutic application,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19135800&form=6&db=m Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19210906&form=6&db=m Aspirin sensitivity and desensitization for asthma and sinusitis. causal interaction,unassigned 1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19283893&form=6&db=m Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw. unassigned -
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19813464&form=6&db=m Possible link between history of hypersensitivity to a specific non-steroidal anti-inflammatory drug (NSAID) and positive results following challenge test to alternative NSAIDS. diagnostic usage,unassigned 2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20395821&form=6&db=m Effects of intrathecal ketorolac on human experimental pain. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519889&form=6&db=m Analgesics. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20525116&form=6&db=m Nonsteroidal anti-inflammatory drug hypersensitivity in preschool children. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21217919&form=6&db=m Aspirin-exacerbated respiratory disease: evaluation and management. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21734176&form=6&db=m CXCL5 mediates UVB irradiation-induced pain. causal interaction,unassigned 3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21834936&form=6&db=m Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22123288&form=6&db=m Expression of Arachidonate Metabolism Enzymes and Receptors in Nasal Polyps of Aspirin-Hypersensitive Asthmatics. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22154852&form=6&db=m Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D(2) generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells. ongoing research,unassigned 3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22229445&form=6&db=m Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249337&form=6&db=m Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain. causal interaction,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22309829&form=6&db=m Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model. therapeutic application,unassigned 2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22373734&form=6&db=m Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22386242&form=6&db=m N-Caffeoyl serotonin as selective COX-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416915&form=6&db=m Association of the -14C/G MET and the -765G/C COX-2 Gene Polymorphisms with the Risk of Chronic Rhinosinusitis with Nasal Polyps in a Polish Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613973&form=6&db=m Identification of cis-acting elements and signaling components of high affinity IgE receptor that regulate the expression of cyclooxygenase-2. unassigned -
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23031659&form=6&db=m Are drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity? causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23140569&form=6&db=m Inflammation, allergy and asthma, complex immune origin diseases: mechanisms and therapeutic agents. causal interaction,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23513960&form=6&db=m Method development and validation for ultra-high pressure liquid chromatography/tandem mass spectrometry determination of multiple prostanoids in biological samples. therapeutic application,unassigned 1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23678553&form=6&db=m Cutaneous hypersensitivity to multiple NSAIDs: never take tolerance to selective COX-2 inhibitors (COXIBs) for granted! therapeutic application,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23799898&form=6&db=m Tolerance to alternative cyclooxygenase-2 inhibitors in nonsteroidal anti-inflammatory drug hypersensitive patients. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24116718&form=6&db=m Tolerance to COX-2 inhibitors in children with hypersensitivity to nonsteroidal anti-inflammatory drugs. therapeutic application,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535482&form=6&db=m Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24992549&form=6&db=m Avoidance of nonsteroidal anti-inflammatory drugs after negative provocation tests in urticaria/angioedema reactions: Real-world experience. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25573836&form=6&db=m Significance of CYCLOOXYGENASE-2(COX-2), PERIOSTIN (POSTN) and INTERLEUKIN-4(IL-4) gene expression in the pathogenesis of chronic rhinosinusitis with nasal polyps. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25590318&form=6&db=m State of the Art: Medical treatment of aspirin exacerbated respiratory disease (AERD). causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25599304&form=6&db=m Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25653919&form=6&db=m Tolerance to etoricoxib in children with nonsteroidal anti-inflammatory drug hypersensitivity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25907560&form=6&db=m MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells. causal interaction,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26194538&form=6&db=m Platelet activation markers overexpressed specifically in patients with aspirin-exacerbated respiratory disease. unassigned -
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546510&form=6&db=m Celecoxib reverts oxaliplatin-induced neuropathic pain through inhibiting PI3K/Akt2 pathway in the mouse dorsal root ganglion. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27272369&form=6&db=m [«Sulfonamide allergy» - which drugs must patients avoid?]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27534531&form=6&db=m Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease. causal interaction,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27576781&form=6&db=m Mucosal exfoliation as a selective reaction to etoricoxib. therapeutic application,unassigned 3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28684647&form=6&db=m Hypersensitivity to antipyretics: pathogenesis, diagnosis, and management. unassigned -
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28809071&form=6&db=m Physicians' communication of risks from non-steroidal anti-inflammatory drugs and attitude towards providing adverse drug reaction information to patients. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28859704&form=6&db=m An update on the epidemiology of aspirin-exacerbated respiratory disease. causal interaction,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28859705&form=6&db=m Immunoglobulin G4 sinusitis in association with aspirin-exacerbated respiratory disease. causal interaction,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28893093&form=6&db=m Practical approach to the treatment of NSAID hypersensitivity. therapeutic application,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29105869&form=6&db=m Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29883727&form=6&db=m Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30358302&form=6&db=m [Management of Adverse Effects Associated with Nonsteroidal Anti-inflammatory Drugs and COX-2 Inhibitor]. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30620999&form=6&db=m High Expression of IL-1RI and EP? Receptors in the IL-1?/COX-2 Pathway, and a New Alternative to Non-Steroidal Drugs-Osthole in Inhibition COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30953868&form=6&db=m A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31256492&form=6&db=m Paracetamol allergy in clinical practice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31469167&form=6&db=m Progress in understanding hypersensitivity reactions to nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31576420&form=6&db=m Sex differences in vascular reactivity of coronary artery bypass graft conduits. unassigned -
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31587584&form=6&db=m COX-2 induces T cell accumulation and IFN-? production during the development of chromium allergy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31984719&form=6&db=m [Allergy and intolerance to nonsteroidal anti-inflammatory drugs in children]. diagnostic usage,unassigned 1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32042330&form=6&db=m Sex Differences Revealed in a Mouse CFA Inflammation Model with Macrophage Targeted Nanotheranostics. causal interaction,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32084424&form=6&db=m Prostaglandin E2, Produced by Mast Cells in Colon Tissues from Patients with Irritable Bowel Syndrome, Contributes to Visceral Hypersensitivity in Mice. ongoing research,unassigned 4,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32786099&form=6&db=m Behind the scene: Paracetamol hypersensitivity in children. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32789114&form=6&db=m Tolerability to paracetamol and preferential COX-2 inhibitors in patients with cross-reactive nonsteroidal anti-inflammatory drugs hypersensitivity. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450044&form=6&db=m Deep sequencing of prostaglandin-endoperoxide synthase (PTGE) genes reveals genetic susceptibility for cross-reactive hypersensitivity to NSAID. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33908261&form=6&db=m An opioid receptor-independent mechanism underlies motility dysfunction and visceral hyperalgesia in opioid-induced bowel dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33955560&form=6&db=m Polymorphisms in eicosanoid-related biosynthesis enzymes associated with acute urticaria/angioedema induced by nonsteroidal anti-inflammatory drug hypersensitivity. causal interaction,unassigned 2,0
1.14.99.1 Hypersensitivity, Delayed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2844191&form=6&db=m Effects of cyclooxygenase and lipoxygenase inhibitors on inflammation associated with oxazolone-induced delayed hypersensitivity. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hypersensitivity, Delayed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10665781&form=6&db=m Selective cyclooxygenase-2 (COX-2) inhibitors reduce anti-Mycobacterium antibodies in adjuvant arthritic rats. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Hypersensitivity, Delayed http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15180311&form=6&db=m Inhibition of contact dermatitis in animal models and suppression of proinflammatory gene expression by topically applied flavonoid, wogonin. therapeutic application,unassigned 1,0
1.14.99.1 Hypersensitivity, Immediate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3752717&form=6&db=m Human respiratory mucus. causal interaction,unassigned 2,0
1.14.99.1 Hypersensitivity, Immediate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9050016&form=6&db=m Release of calcitonin gene-related peptide in cardiac anaphylaxis. therapeutic application,unassigned 1,0
1.14.99.1 Hypersensitivity, Immediate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20684128&form=6&db=m [Immediate hypersenstivity reactions to nonsteroidal anti-inflammatory drugs: allergy or pseudo-allergy?] therapeutic application,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=826839&form=6&db=m Prostaglandin synthetase activity in kidney medulla during the development of experimental hypertension in the rat. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1483337&form=6&db=m Intracamerally injected platelet activating factor (PAF) induces marked intraocular inflammatory reactions. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1627331&form=6&db=m Post-ischemic rupture of the anterior papillary muscle of the right ventricle associated with persistent pulmonary hypertension of the newborn: a case report. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1909312&form=6&db=m Cyclooxygenase pathway mediates lung injury induced by phorbol and platelets. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2457762&form=6&db=m Cyclosporin A and pressor responsiveness in sheep. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496411&form=6&db=m Indomethacin and LY171883 modify porcine cardiopulmonary responses to leukotrienes. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2680959&form=6&db=m Aspirin lowers blood pressure in patients with renovascular hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2994903&form=6&db=m George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3093772&form=6&db=m Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6313251&form=6&db=m Role of intrapulmonary release of eicosanoids and superoxide anion as mediators of pulmonary dysfunction and endothelial injury in sheep with intermittent complement activation. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6507633&form=6&db=m Glomerular prostaglandin formation in two-kidney, one-clip hypertensive rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7223903&form=6&db=m Mechanism of cerebral arteriolar abnormalities after acute hypertension. therapeutic application,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8113009&form=6&db=m Free radicals in retinal and choroidal blood flow autoregulation in the piglet: interaction with prostaglandins. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9440240&form=6&db=m Lung oedema induced by Tityus serrulatus scorpion venom in the rat. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9556499&form=6&db=m Vascular smooth muscle, endothelial regulation and effects of aspirin in hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10329876&form=6&db=m The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10734155&form=6&db=m Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10744360&form=6&db=m Cyclooxygenase inhibition reduces blood pressure elevation and vascular reactivity dysfunction caused by inhibition of nitric oxide synthase in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10844603&form=6&db=m A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10864134&form=6&db=m Nimesulide: some pharmaceutical and pharmacological aspects--an update. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899070&form=6&db=m Effect of the NADPH oxidase inhibitor apocynin on ischemia-reperfusion lung injury. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11065217&form=6&db=m Increased renal vasoconstriction and gene expression of cyclooxygenase-1 in renovascular hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11165997&form=6&db=m Cyclooxygenase-2--specific inhibitors: are they safe? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11177775&form=6&db=m COX-2 inhibitors in rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11249495&form=6&db=m Rofecoxib. causal interaction,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11499548&form=6&db=m Expression of cyclooxygenase-2 in the macula densa of human kidney in hypertension, congestive heart failure, and diabetic nephropathy. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695250&form=6&db=m COX-2 inhibitors and the kidney. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11737606&form=6&db=m Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11909557&form=6&db=m Effects of nonsteroidal anti-inflammatory drug therapy on blood pressure and peripheral edema. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11981317&form=6&db=m Specific cyclooxygenase-2 inhibitors: what have we learned since they came into widespread clinical use? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12109923&form=6&db=m Cardiovascular risk profile of antirheumatic agents in patients with osteoarthritis and rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164875&form=6&db=m Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429553&form=6&db=m Role of macula densa cyclooxygenase-2 in renovascular hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12484518&form=6&db=m Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12512695&form=6&db=m Vascular effects of COX inhibition and AT1 receptor blockade in transgenic rats harboring mouse renin-2 gene. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530941&form=6&db=m Does cyclooxygenase-2 affect blood pressure? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573196&form=6&db=m Cyclooxygenase-2 inhibitors: is there an association with coronary or renal events? therapeutic application,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12639178&form=6&db=m Effect of cyclooxygenase-2 inhibitors on blood pressure. therapeutic application,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12640241&form=6&db=m Do COX-2 inhibitors really prevent hypertension and proteinuria? Another brick in the wall for the COX-2 inhibition and cardiovascular disease controversy. therapeutic application,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12640255&form=6&db=m Inhibition of COX-2 prevents hypertension and proteinuria associated with a decrease of 8-iso-PGF2alpha formation in L-NAME-treated rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12745131&form=6&db=m Blood pressure control and rates of edema following the administration of the cyclooxygenase-2 specific inhibitors celecoxib versus rofecoxib in patients with systemic hypertension and osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12749519&form=6&db=m A model analysis of costs of blood pressure destabilization and edema associated with rofecoxib and celecoxib among older patients with osteoarthritis and hypertension in a Medicare Choice population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12874094&form=6&db=m Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12913255&form=6&db=m Analysis of angiotensin II mediated COX-2 downregulation in angiotensin II- or aldosterone-infused hypertensive rat. ongoing research,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12923388&form=6&db=m Endothelial COX-2 inhibition: possible relevance for hypertension and cardiovascular risk? unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14508588&form=6&db=m Nonsteroidal anti-inflammatory drugs in patients with cardio- or cerebrovascular disorders. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597594&form=6&db=m Differential effects of selective cyclooxygenase-2 inhibitors on endothelial function in salt-induced hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623032&form=6&db=m Cyclooxygenase pathway is involved in the vascular reactivity and inhibition of the Na+, K+-ATPase activity in the tail artery from L-NAME-treated rats. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633140&form=6&db=m Cyclooxygenase-2 (COX-2) inhibition limits abnormal COX-2 expression and progressive injury in the remnant kidney. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14637180&form=6&db=m Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691350&form=6&db=m Renal cyclooxygenase-2 (COX-2). Physiological, pathophysiological, and clinical implications. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14718360&form=6&db=m Role for thromboxane receptors in angiotensin-II-induced hypertension. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14757778&form=6&db=m Androgens are necessary for the development of fructose-induced hypertension. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15001439&form=6&db=m Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries. ongoing research,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075190&form=6&db=m Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory. causal interaction,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15167446&form=6&db=m Genetic analysis of 22 candidate genes for hypertension in the Japanese population. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15226279&form=6&db=m Relationship between COX-2 specific inhibitors and hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15273422&form=6&db=m Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake. ongoing research,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15314032&form=6&db=m Inhibition of cyclooxygenase-2 in the rat renal medulla leads to sodium-sensitive hypertension. ongoing research,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15314033&form=6&db=m Hypertension and cyclooxygenase-2 inhibitors: target: the renal medulla. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319202&form=6&db=m Nitric oxide synthase-inhibition hypertension is associated with altered endothelial cyclooxygenase function. causal interaction,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15340111&form=6&db=m Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385947&form=6&db=m Cardiovascular risk and COX-2 inhibition in rheumatological practice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471166&form=6&db=m Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15528468&form=6&db=m Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15607496&form=6&db=m Coronary action of endothelin-1 and vasopressin during acute hypertension in anesthetized goats. Role of nitric oxide and prostanoids. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15613621&form=6&db=m Influence of genetic background and gender on hypertension and renal failure in COX-2-deficient mice. ongoing research,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630049&form=6&db=m Selective COX-2 inhibitors and renal injury in salt-sensitive hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15668361&form=6&db=m The Effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension, osteoarthritis, and type 2 diabetes mellitus. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683587&form=6&db=m Anti-inflammatory strategies in hypertension: focus on COX-1 and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710786&form=6&db=m Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15717837&form=6&db=m Effects of sodium restriction and cyclooxygenase-2 inhibition on the course of hypertension, proteinuria and cardiac hypertrophy in Ren-2 transgenic rats. ongoing research,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15718388&form=6&db=m Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719708&form=6&db=m Rationale for testing the cardiovascular risk for patients with COX-2 inhibitors on the basis of biomarker NT-proBNP. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15775781&form=6&db=m Hypertension increases the participation of vasoconstrictor prostanoids from cyclooxygenase-2 in phenylephrine responses. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15813652&form=6&db=m Cyclo-oxygenase-2 inhibitors: when should they be used in the elderly? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15834289&form=6&db=m Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension. causal interaction,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15851630&form=6&db=m Cyclooxygenase-2 inhibitors attenuate angiotensin II-induced oxidative stress, hypertension, and cardiac hypertrophy in rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15892676&form=6&db=m Renal effects of non-steroidal anti-inflammatory drugs and selective cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899741&form=6&db=m Celecoxib-induced nephrotoxicity in a renal transplant recipient. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15905461&form=6&db=m COX-2-derived prostacyclin modulates vascular remodeling. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15940774&form=6&db=m Efficacy of rofecoxib, celecoxib, and acetaminophen in patients with osteoarthritis of the knee. A combined analysis of the VACT studies. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15957551&form=6&db=m Nephrotoxicity related to new therapeutic compounds. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15998959&form=6&db=m Utilization of non-steroidal anti-inflammatory drugs in Quebec: adherence to the Canadian consensus on prescription guidelines. diagnostic usage,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16049546&form=6&db=m Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113940&form=6&db=m Adverse effects of COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16133552&form=6&db=m COX-2 inhibitors and arterial hypertension: an analysis of spontaneous case reports in the Pharmacovigilance database. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16154102&form=6&db=m Prostacyclin protects against elevated blood pressure and cardiac fibrosis. causal interaction,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16235511&form=6&db=m Adverse interactions of rofecoxib with lisinopril in spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16304418&form=6&db=m The Cardiovascular Pharmacology of COX-2 Inhibition. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16316349&form=6&db=m Increase in heme oxygenase-1 levels ameliorates renovascular hypertension. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16354389&form=6&db=m The use of NSAIDs in rheumatic disorders 2005: a global perspective. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16401468&form=6&db=m Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16467505&form=6&db=m Effect of apocynin treatment on renal expression of COX-2, NOS1, and renin in Wistar-Kyoto and spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16586083&form=6&db=m Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16741783&form=6&db=m Update on guidelines for the treatment of chronic musculoskeletal pain. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785827&form=6&db=m COX-2 and the kidney. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935907&form=6&db=m Chronic inhibition of NOS-2 ameliorates renal injury, as well as COX-2 and TGF-beta 1 overexpression in 5/6 nephrectomized rats. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16968832&form=6&db=m Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17086563&form=6&db=m Use of cyclo-oxygenase 2 inhibitors (COX-2) and prescription non-steroidal anti-inflammatory drugs (NSAIDS) in UK and USA populations. Implications for COX-2 cardiovascular profile. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244722&form=6&db=m Losartan reduces the increased participation of cyclooxygenase-2-derived products in vascular responses of hypertensive rats. causal interaction,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17272666&form=6&db=m Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17362663&form=6&db=m COX-2 inhibitors and hypertension. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17362670&form=6&db=m Painful lessons: COX-2 inhibitors, NSAIDs, and hypertension. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17383621&form=6&db=m Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition. therapeutic application,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437665&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17469317&form=6&db=m [Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17488830&form=6&db=m New diagnosis of hypertension among celecoxib and nonselective NSAID users: a population-based cohort study. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17636006&form=6&db=m Intra-renal angiotensin II/AT1 receptor, oxidative stress, inflammation, and progressive injury in renal mass reduction. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17641732&form=6&db=m Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model. ongoing research,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17766473&form=6&db=m Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension. ongoing research,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17976347&form=6&db=m Do COX-2 inhibitors worsen renal function? causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18056786&form=6&db=m Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094033&form=6&db=m Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173977&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18185149&form=6&db=m Use of cox-2 inhibitors in patients with retinal venous occlusive disease. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18234738&form=6&db=m Perinatal lead exposure affects nitric oxide and cyclooxygenase pathways in aorta of weaned rats. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18552867&form=6&db=m Mechanisms of augmented vasoconstriction induced by 5-hydroxytryptamine in aortic rings from spontaneously hypertensive rats. therapeutic application,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695943&form=6&db=m Association of non-steroidal anti-inflammatory drugs with outcomes in patients with ST-segment elevation myocardial infarction treated with fibrinolytic therapy: an ExTRACT-TIMI 25 analysis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18797164&form=6&db=m Effect of Exercise on Cardiac Tissue Oxidative and Inflammatory Mediators in Chronic Kidney Disease. ongoing research,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19103998&form=6&db=m Hypertension and sex differences in the age-related renal changes when cyclooxygenase-2 activity is reduced during nephrogenesis. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19282863&form=6&db=m Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19420110&form=6&db=m NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE. causal interaction,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630805&form=6&db=m The translational therapeutics of prostaglandin inhibition in atherothrombosis. therapeutic application,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630832&form=6&db=m Endothelium-dependent contractions and endothelial dysfunction in human hypertension. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19656915&form=6&db=m Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney. causal interaction,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19770404&form=6&db=m Intrarenal Dopamine Attenuates Deoxycorticosterone Acetate/High Salt-Induced Blood Pressure Elevation in Part Through Activation of a Medullary Cyclooxygenase 2 Pathway. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19952427&form=6&db=m Examination of the expression of cyclooxygenase-2 in placenta villi from sufferers of pregnancy induced hypertension. ongoing research,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20057489&form=6&db=m Rosiglitazone prevents the progression of renal injury in DOCA-salt hypertensive rats. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20091049&form=6&db=m Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20107114&form=6&db=m Tubuloglomerular feedback is decreased in COX-1 knockout mice after chronic angiotensin II infusion. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20107721&form=6&db=m Psoriasis and hypertension: a case-control study. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20370791&form=6&db=m Natural Antioxidants and Hypertension: Promise and Challenges. causal interaction,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20498929&form=6&db=m [Nonsteroidal anti-inflammatory drugs: cardiovascular, cerebrovascular and renal effects] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20539104&form=6&db=m Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale. therapeutic application,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20632668&form=6&db=m Effects of chronic treatment with cyclooxygenase inhibitor, indomethacin on oral contraceptive-induced high blood pressure in female rats. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635093&form=6&db=m Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20724703&form=6&db=m Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20735790&form=6&db=m Prenatal Undernutrition Changes Renovascular Responses of Nimesulide in Rat Kidneys. therapeutic application,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20844610&form=6&db=m Prostacyclin therapy for pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21081215&form=6&db=m Prostaglandins in action indispensable roles of cyclooxygenase-1 and -2 in endothelium-dependent contractions. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21441310&form=6&db=m RENAL PROTECTIVE EFFECT OF CHRONIC INHIBITION OF COX-2 WITH SC58236 IN STREPTOZOTOCIN-DIABETIC RATS. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479425&form=6&db=m Association of the genetic variants of APOA5 and PRKCH with hypertension in community-dwelling Japanese individuals. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21701066&form=6&db=m Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21733195&form=6&db=m Cause for concern in the use of non-steroidal anti-inflammatory medications in the community -a population-based study. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21843325&form=6&db=m Cardiovascular events in early rheumatoid arthritis (RA) are a result of inflammatory burden and traditional risk factors: a five year prospective study. therapeutic application,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22008968&form=6&db=m COX-2 and angiotensin II-induced hypertension and oxidative stress. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22101002&form=6&db=m Eicosanoids and tumor necrosis factor-alpha in the kidney. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22119250&form=6&db=m Cyclooxygenase-2 and kidney failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179086&form=6&db=m Peroxisome proliferator-activated receptor-? activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22190908&form=6&db=m Peroxisome Proliferator-Activated Receptor-? Activation Decreases Mean Arterial Pressure, Plasma Interleukin-6, and COX-2 While Increasing Renal CYP4A Expression in an Acute Model of DOCA-Salt Hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22238745&form=6&db=m Correction of endothelial dysfunction in patients with arterial hypertension. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22306536&form=6&db=m Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371360&form=6&db=m Angiotensin II-Dependent Hypertension Requires Cyclooxygenase 1-Derived Prostaglandin E2 and EP1 Receptor Signaling in the Subfornical Organ of the Brain. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22448321&form=6&db=m The role of dermcidin isoform 2: a two-faceted atherosclerotic risk factor for coronary artery disease and the effect of acetyl salicylic Acid on it. causal interaction,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22465182&form=6&db=m Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553252&form=6&db=m Vascular COX-2 modulates blood pressure and thrombosis in mice. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22671943&form=6&db=m Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848208&form=6&db=m Peroxisome Proliferator Activated Receptor-? Agonist Slows the Progression of Hypertension, Attenuates Plasma Interleukin-6 Levels and Renal Inflammatory Markers in Angiotensin II Infused Mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22870450&form=6&db=m Treatment strategies for osteoarthritis patients with pain and hypertension. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23109673&form=6&db=m Effect of sphingosine kinase 1 inhibition on blood pressure. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23232839&form=6&db=m Endothelial Dysfunction in Diabetes and Hypertension: Cross Talk in RAS, BMP4, and ROS-dependent COX-2-derived Prostanoids. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489008&form=6&db=m Etoricoxib Attenuates Effect of Antihypertensives in a Rodent Model of DOCA-Salt Induced Hypertension. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23681850&form=6&db=m Cyclooxygenase-2 expression in lung in patients with congenital heart malformations and pulmonary arterial hypertension. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23953622&form=6&db=m Variability in the Response to Non-Steroidal Anti-Inflammatory Drugs: Mechanisms and Perspectives. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24012611&form=6&db=m Differential role of cyclooxygenase-1 and -2 on renal vasoconstriction to ?1-adrenoceptor stimulation in normotensive and hypertensive rats. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24014677&form=6&db=m Cyclooxygenase-1 inhibition attenuates angiotensin II-salt hypertension and neurogenic pressor activity in the rat. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337227&form=6&db=m H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24652215&form=6&db=m [Association and interaction of AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R and PTGS2 genes on the risk of hypertension in Antioquian population]. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24661554&form=6&db=m Renal molecular mechanisms underlying altered Na+ handling and genesis of hypertension during adulthood in prenatally undernourished rats. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727493&form=6&db=m Pioglitazone reduces angiotensin II-induced COX-2 expression through the inhibition of ROS production and ET-1 transcription in vascular cells from SHR rats. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24740788&form=6&db=m COX-2 mediates angiotensin II-induced (pro)renin receptor expression in the rat renal medulla. ongoing research,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24878773&form=6&db=m Vasoconstrictor role of cyclooxygenase-1-mediated prostacyclin synthesis in non-insulin-dependent diabetic mice induced by high-fat diet and streptozotocin. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25143455&form=6&db=m Renal medullary cyclooxygenase-2 and (pro)renin receptor expression during angiotensin II-dependent hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25489058&form=6&db=m Brain-targeted Angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25584932&form=6&db=m The impact of ethnicity and cardiovascular risk on the pharmacologic management of osteoarthritis: a US perspective. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25596430&form=6&db=m MAPK pathway activation by chronic lead-exposure increases vascular reactivity through oxidative stress/cyclooxygenase-2-dependent pathways. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25681793&form=6&db=m Crosstalk between (Pro)renin receptor and COX-2 in the renal medulla during angiotensin II-induced hypertension. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748877&form=6&db=m Cardiovascular risks associated with non-aspirin non-steroidal anti-inflammatory drug use. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25761067&form=6&db=m Early co-expression of cyclooxygenase-2 and renin in the rat kidney cortex contributes to the development of N(G)-nitro-l-arginine methyl ester induced hypertension. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25846103&form=6&db=m Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26308616&form=6&db=m Vasomotor Reaction to Cyclooxygenase-1-Mediated Prostacyclin Synthesis in Carotid Arteries from Two-Kidney-One-Clip Hypertensive Mice. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26426591&form=6&db=m Parecoxib Increases Blood Pressure Through Inhibition of Cyclooxygenase-2 Messenger RNA in an Experimental Model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26485285&form=6&db=m Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26553519&form=6&db=m Hypertension: Haematopoietic COX-2 in salt-sensitive hypertension. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27225954&form=6&db=m Possible role for brain prostanoid pathways in the development of angiotensin II-salt hypertension in rats. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27245461&form=6&db=m Vascular Smooth Muscle-Specific EP4 Receptor Deletion in Mice Exacerbates Angiotensin II-Induced Renal Injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713354&form=6&db=m Nonsteroidal Anti-Inflammatory Drugs and the Kidney. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27803479&form=6&db=m Analysis of Vascular Cell Response to Hypertension Induced by Pressure Loading and Its Application as a Tool for Exploring Pharmacological Modes of Action. diagnostic usage,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27814606&form=6&db=m Regulation and function of renal medullary cyclooxygenase-2 during high salt loading. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28003191&form=6&db=m Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28054752&form=6&db=m Opposite Modulatory Effects of Selective and Non-Selective Cyclooxygenase Inhibition on Cardiovascular and Autonomic Consequences of Cyclosporine in Female Rats. therapeutic application,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28105253&form=6&db=m Demethoxycurcumin Preserves Renovascular Function by Downregulating COX-2 Expression in Hypertension. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28412461&form=6&db=m Effects of low-dose aspirin on maternal blood pressure and vascular function in an experimental model of gestational hypertension. therapeutic application,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449186&form=6&db=m The risk of lower gastrointestinal bleeding in low-dose aspirin users. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28569569&form=6&db=m Nonsteroidal anti-inflammatory drugs and cardiovascular safety - translating pharmacological data into clinical readouts. causal interaction,unassigned 2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28739304&form=6&db=m Role of NADPHox/Rho-kinase signaling in the cyclosporine-NSAIDs interactions on blood pressure and baroreflexes in female rats. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29449428&form=6&db=m A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels. causal interaction,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29468706&form=6&db=m Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29521599&form=6&db=m Celecoxib restores angiogenic factor expression at the maternal-fetal interface in the BPH/5 mouse model of preeclampsia. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29698447&form=6&db=m Celecoxib use and circulating oxylipins in a colon polyp prevention trial. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29996846&form=6&db=m Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108767&form=6&db=m Structure-activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009-2016). causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30354807&form=6&db=m Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30386795&form=6&db=m Interactions between the Cyclooxygenase Metabolic Pathway and the Renin-Angiotensin-Aldosterone Systems: Their Effect on Cardiovascular Risk, from Theory to the Clinical Practice. causal interaction,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31073922&form=6&db=m Safety of Cyclooxygenase-2 Inhibitors in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31183001&form=6&db=m Ethyl Acetate Fraction of Lannea microcarpa Engl. and K. Krause (Anacardiaceae) Trunk Barks Corrects Angiotensin II-Induced Hypertension and Endothelial Dysfunction in Mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31378107&form=6&db=m Regulation of YAP by Mammalian Target of Rapamycin Complex 1 in Endothelial Cells Controls Blood Pressure Through COX-2/mPGES-1/PGE2 Cascade. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31378306&form=6&db=m Angiotensin II induces cyclooxygenase 2 expression in rat astrocytes via the angiotensin type 1 receptor. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31680980&form=6&db=m Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31745719&form=6&db=m Long-term Mercury Exposure Accelerates the Development of Hypertension in Prehypertensive Spontaneously Hypertensive Rats Inducing Endothelial Dysfunction: the Role of Oxidative Stress and Cyclooxygenase-2. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31852420&form=6&db=m Low-Dose Aspirin Treatment Attenuates Male Rat Salt-Sensitive Hypertension via Platelet Cyclooxygenase 1 and Complement Cascade Pathway. therapeutic application,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32303165&form=6&db=m The Obligatory Role of the Acetylcholine-Induced Endothelium-Dependent Contraction in Hypertension: Can Arachidonic Acid Resolve this Inflammation? unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32310965&form=6&db=m Relative risk of end-stage renal disease requiring dialysis in treated ankylosing spondylitis patients compared with individuals without ankylosing spondylitis: A nationwide, population-based, matched-cohort study. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32516287&form=6&db=m Association of plasma cyclooxygenase-2 levels and genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32738273&form=6&db=m Cadmium exposure activates NADPH oxidase, renin-angiotensin system and cyclooxygenase 2 pathways in arteries, inducing hypertension and vascular damage. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32799674&form=6&db=m COX-2-Independent Activation of Renal (Pro)Renin Receptor Contributes to DOCA-Salt Hypertension in Rats. ongoing research,unassigned 4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32909857&form=6&db=m Calcitriol inhibits COX-1 and COX-2 expressions of renal vasculature in hypertension: Reactive oxygen species involved? causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33013911&form=6&db=m Scientific Rationale for a Bottom-Up Approach to Target the Host Response in Order to Try and Reduce the Numbers Presenting With Adult Respiratory Distress Syndrome Associated With COVID-19. Is There a Role for Statins and COX-2 Inhibitors in the Prevention and Early Treatment of the Disease? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33548997&form=6&db=m The prescription patterns and safety profiles of oral non-steroidal anti-inflammatory drugs in China: an 8-year real-life analysis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609791&form=6&db=m Risk factors for hypertension in rheumatoid arthritis patients-A systematic review. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33716792&form=6&db=m Vascular and Macrophage Heme Oxygenase-1 in Hypertension: A Mini-Review. unassigned -
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34052431&form=6&db=m Chronic cyclooxygenase-2 inhibition prevents the worsening of hypertension and endothelial dysfunction induced by ouabain in resistance arteries of spontaneously hypertensive rats. causal interaction,unassigned 3,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34078818&form=6&db=m Abnormal Pressure Stress Reduces Interleukin-1?-Induced Cyclooxygenase-2 Expression in Cultured Rat Vascular Smooth Muscle Cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34405222&form=6&db=m [Research advances of prostaglandin E2 synthases and receptors in cardiovascular diseases]. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hypertension, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622181&form=6&db=m Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypertension, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17977909&form=6&db=m Renoprotective effects of neuronal NOS-derived nitric oxide and cyclooxygenase-2 metabolites in transgenic rats with inducible malignant hypertension. ongoing research,unassigned 4,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8244267&form=6&db=m Effects of nitric oxide and cyclooxygenase inhibition on splanchnic hemodynamics in portal hypertension. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10440208&form=6&db=m A selective cyclo-oxygenase-2 inhibitor, NS-398, may improve portal hypertension without inducing gastric mucosal injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12181171&form=6&db=m Endothelial COX-1 and -2 differentially affect reactivity of MVB in portal hypertensive rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795648&form=6&db=m Cyclooxygenase expression in splanchnic hyposensitivity to glypressin of bleeding portal hypertensive rats. ongoing research,unassigned 2,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678698&form=6&db=m [Role of cyclooxygenase-2 in the pathogenesis of chronic liver diseases] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845610&form=6&db=m Selective cyclooxygenase (COX) inhibition causes damage to portal hypertensive gastric mucosa: roles of nitric oxide and NF-kappaB. unassigned -
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17085343&form=6&db=m Influence of nitric oxide synthase and cyclooxygenase blockade on expression of cyclooxygenase and hemodynamics in rats with portal hypertension. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17258737&form=6&db=m Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17565644&form=6&db=m Antifibrotic activity of rofecoxib in vivo is associated with reduced portal hypertension in rats with carbon tetrachloride-induced liver injury. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17876871&form=6&db=m Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. therapeutic application,unassigned 3,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18221099&form=6&db=m The role of angiotensin type 1 receptor in inflammation and endothelial dysfunction. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18772366&form=6&db=m Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension. ongoing research,unassigned 2,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18842497&form=6&db=m Role of nitric oxide synthase and cyclooxygenase in hyperdynamic splanchnic circulation of portal hypertension. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23922700&form=6&db=m Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. causal interaction,unassigned 3,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26072731&form=6&db=m Arachidonic acid metabolites and endothelial dysfunction of portal hypertension. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26619541&form=6&db=m [The Expressions of Somatostatin and Cycloxygenase-2 in Chronic Hepatitis, Hepatic Cirrhosis, Precancerous Lesion and Hepatocellular Carcinoma]. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28213942&form=6&db=m PGE therapeutic application,unassigned 1,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28712920&form=6&db=m Amelioration of cirrhotic portal hypertension by targeted cyclooxygenase-1 siRNA delivery to liver sinusoidal endothelium with polyethylenimine grafted hyaluronic acid. unassigned -
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31005060&form=6&db=m Effects of Ultra-Low-Dose Aspirin in Thrombosis and Haemorrhage. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Hypertension, Portal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32821072&form=6&db=m Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1964752&form=6&db=m Increased placental production of leukotriene B4 in gestational hypertension. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3923569&form=6&db=m Control of prostacyclin synthesis in pregnancy-induced hypertension. unassigned -
1.14.99.1 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8066098&form=6&db=m Cyclooxygenase gene expression in human endometrium and decidua. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9556499&form=6&db=m Vascular smooth muscle, endothelial regulation and effects of aspirin in hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Hypertension, Pregnancy-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19952427&form=6&db=m Examination of the expression of cyclooxygenase-2 in placenta villi from sufferers of pregnancy induced hypertension. ongoing research,unassigned 2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1474095&form=6&db=m Enhanced microvascular permeability of PMA-induced acute lung injury is not mediated by cyclooxygenase products. causal interaction,unassigned 4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1537723&form=6&db=m Blunted hypoxic vasoconstriction in oleic acid lung injury: effect of cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1540090&form=6&db=m Monoclonal antibody to tumor necrosis factor alpha attenuates cardiopulmonary dysfunction in porcine gram-negative sepsis. unassigned -
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1554206&form=6&db=m Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1594324&form=6&db=m Impact of prostaglandin and thromboxane synthesis blockade on disposition of group B streptococcus in lung and liver of intact piglet. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1711633&form=6&db=m In vivo enhancement of platelet activating factor-induced prostacyclin production by OKY-046, a selective inhibitor of thromboxane A2 synthase. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1716064&form=6&db=m Leukotrienes, thromboxane A2, and prostaglandins during systemic anaphylaxis in sheep. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2111555&form=6&db=m Pulmonary hypertensive response to foreign body microemboli. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2506581&form=6&db=m Lipoxygenase and cyclooxygenase blockade by BW755C does not prevent the secondary phase of septic pulmonary hypertension. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3093772&form=6&db=m Indomethacin, dazoxiben and extravascular lung water after Escherichia coli infusion. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3112984&form=6&db=m Successful treatment of adult respiratory distress syndrome by histamine and prostaglandin blockade in a porcine Pseudomonas model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3431953&form=6&db=m Effects of indomethacin in utero on the pulmonary vasculature of the newborn guinea pig. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3530674&form=6&db=m Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3921978&form=6&db=m Pulmonary dysfunction caused by diffuse lung inflammation. Roles of metabolites of arachidonic acid. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3923843&form=6&db=m Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3931473&form=6&db=m The pulmonary hypertension of sclerosing agents is prevented by cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6313251&form=6&db=m Role of intrapulmonary release of eicosanoids and superoxide anion as mediators of pulmonary dysfunction and endothelial injury in sheep with intermittent complement activation. causal interaction,unassigned 3,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6427147&form=6&db=m Cyclooxygenase inhibition during phorbol-induced granulocyte stimulation in awake sheep. causal interaction,unassigned 4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6808526&form=6&db=m Effects of cyclooxygenase inhibitors on pulmonary vascular responses to endotoxin in unanesthetized sheep. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7380683&form=6&db=m Arachidonate raises vascular resistance but not permeability in lungs of awake sheep. therapeutic application,unassigned 1,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7509294&form=6&db=m Attenuation of chronic hypoxic pulmonary hypertension in rats by cyclooxygenase products and by nitric oxide. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7759418&form=6&db=m Effect of blood and albumin on pulmonary hypertension and edema in perfused rabbit lungs. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7945625&form=6&db=m Isolated small bowel perforation following intrauterine treatment with indomethacin. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8002544&form=6&db=m Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8087135&form=6&db=m Chronic bronchitis: reflex on the pulmonary circulation. causal interaction,unassigned 4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8112447&form=6&db=m Medical treatment of pulmonary hypertension in acute lung disease. causal interaction,unassigned 1,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8356015&form=6&db=m Intrinsic microbicidal activity and pulmonary hypertension in isolated newborn piglet lungs. causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8379340&form=6&db=m Circulatory responses to endothelin-1 and nitric oxide with special reference to endotoxin shock and nitric oxide inhalation. causal interaction,unassigned 3,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8430938&form=6&db=m Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086. therapeutic application,unassigned 2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8847301&form=6&db=m Systemic and pulmonary hypertension after abrupt cessation of prostacyclin: role of thromboxane A2. unassigned -
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8874732&form=6&db=m Pulmonary vascular pressures of strenuously exercising thoroughbreds after administration of phenylbutazone. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187606&form=6&db=m The endothelin receptor antagonist, bosentan, in combination with the cyclooxygenase inhibitor, diclofenac, counteracts pulmonary hypertension in porcine endotoxin shock. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9425643&form=6&db=m Cyclooxygenase products contribute to endothelin-induced pulmonary hypertension and altered lung mechanics in sheep. unassigned -
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10030848&form=6&db=m Bacterial lipopolysaccharide induction of the prostaglandin G/H synthase 2 gene causes thromboxane-dependent pulmonary hypertension in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10385598&form=6&db=m Autocrine function of inducible nitric oxide synthase and cyclooxygenase-2 in proliferation of human and rat pulmonary artery smooth-muscle cells: species variation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10786968&form=6&db=m Gene therapy for acute lung injury. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388340&form=6&db=m Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12391278&form=6&db=m Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492320&form=6&db=m Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15516370&form=6&db=m Cyclooxygenase-2 and an early stage of chronic hypoxia-induced pulmonary hypertension in newborn pigs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055511&form=6&db=m The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs. therapeutic application,unassigned 3,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202923&form=6&db=m The promise of prostaglandins: have they fulfilled their potential as therapeutic targets for the delay of preterm birth? causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16205617&form=6&db=m [Transient right ventricular hypertrophy in a newborn infant exposed in utero to nimesulide] therapeutic application,unassigned 2,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18375790&form=6&db=m Cyclooxygenase-2-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18391113&form=6&db=m Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18542928&form=6&db=m Celecoxib but not the combination of celecoxib+atorvastatin prevents the development of monocrotaline-induced pulmonary hypertension in the rat. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19577709&form=6&db=m Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21850273&form=6&db=m Pulmonary oxidative stress is increased in cyclooxygenase-2 knockdown mice with mild pulmonary hypertension induced by monocrotaline. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22814005&form=6&db=m Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22891569&form=6&db=m [Developmental toxicity of the over-the-counter analgetics and antypiretics]. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25320332&form=6&db=m Intratracheal administration of cyclooxygenase-1-transduced adipose tissue-derived stem cells ameliorates monocrotaline-induced pulmonary hypertension in rats. ongoing research,unassigned 4,0
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26202355&form=6&db=m rs2910164 Polymorphism Confers a Decreased Risk for Pulmonary Hypertension by Compromising the Processing of microRNA-146a. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2
1.14.99.1 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100618180&form=6&db=m Prostaglandin synthetase inhibitors and pulmonary hypertension. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Hypertension, Renal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19539681&form=6&db=m Regulation of ANP secretion from isolated atria by prostaglandins and cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2680959&form=6&db=m Aspirin lowers blood pressure in patients with renovascular hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2748507&form=6&db=m Exaggerated renal thromboxane and prostaglandin release by angiotensin II in suprarenal aortic coarctation hypertension. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453303&form=6&db=m Coordinate expression of cyclooxygenase-2 and renin in the rat kidney in renovascular hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10406830&form=6&db=m Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11065217&form=6&db=m Increased renal vasoconstriction and gene expression of cyclooxygenase-1 in renovascular hypertension. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11728945&form=6&db=m Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors. causal interaction,unassigned 4,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429553&form=6&db=m Role of macula densa cyclooxygenase-2 in renovascular hypertension. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12484518&form=6&db=m Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14501677&form=6&db=m Cyclooxygenase-2 up-regulation in reflux nephropathy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15372104&form=6&db=m Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16316349&form=6&db=m Increase in heme oxygenase-1 levels ameliorates renovascular hypertension. causal interaction,unassigned 3,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16788145&form=6&db=m Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat). causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17766473&form=6&db=m Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension. ongoing research,unassigned 2,0
1.14.99.1 Hypertension, Renovascular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25846103&form=6&db=m Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23369109&form=6&db=m Effects of Hypo- and Hyperthyroidism on Proliferation, Angiogenesis, Apoptosis and Expression of COX-2 in the Corpus Luteum of Female Rats. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Hyperthyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25298361&form=6&db=m Luteal activity of pregnant rats with hypo-and hyperthyroidism. ongoing research,unassigned 2,0
1.14.99.1 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18648200&form=6&db=m Plasma triglycerides as predictors of platelet responsiveness to aspirin in patients after first ischemic stroke. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19420110&form=6&db=m NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE. causal interaction,unassigned 2,0
1.14.99.1 Hypertriglyceridemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26188590&form=6&db=m Fructose-induced inflammation, insulin resistance and oxidative stress: A liver pathological triad effectively disrupted by lipoic acid. ongoing research,unassigned 1,0
1.14.99.1 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15159724&form=6&db=m [The use of nebivolol for the treatment of hypertension in patients with osteoarthrosis] unassigned -
1.14.99.1 Hypertrophy, Left Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31229551&form=6&db=m 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2952022&form=6&db=m Thromboxane does not mediate pulmonary vascular response to monocrotaline pyrrole. therapeutic application,unassigned 2,0
1.14.99.1 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16205617&form=6&db=m [Transient right ventricular hypertrophy in a newborn infant exposed in utero to nimesulide] therapeutic application,unassigned 2,0
1.14.99.1 Hypertrophy, Right Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26788753&form=6&db=m Chronic Normobaric Hypoxia Induces Pulmonary Hypertension in Rats: Role of NF-?B. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Hyperventilation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1572446&form=6&db=m The relative contributions of histamine and prostanoids to bronchoconstriction provoked by isocapnic hyperventilation in asthma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Hyperventilation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2513548&form=6&db=m Effect of indomethacin on the regulation of cerebral blood flow during respiratory alkalosis in newborn piglets. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Hyperventilation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7674011&form=6&db=m Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Hyperventilation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9445308&form=6&db=m Hyperventilation induces release of cytokines from perfused mouse lung. unassigned -
1.14.99.1 Hyperventilation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15815583&form=6&db=m Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition. unassigned -
1.14.99.1 Hyperventilation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26836470&form=6&db=m Corticospinal excitability is associated with hypocapnia but not changes in cerebral blood flow. therapeutic application,unassigned 1,0
1.14.99.1 Hyperventilation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32339697&form=6&db=m Modulation of arachidonic acid-evoked cardiorespiratory effects by the central lipoxygenase pathway. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypoalbuminemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6766753&form=6&db=m The influence of albumin and calcium on human platelet arachidonic acid metabolism. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Hypoaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3375885&form=6&db=m Hyperkalemia induced by indomethacin and naproxen and reversed by fludrocortisone. causal interaction,unassigned 3,0
1.14.99.1 Hypoaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8481348&form=6&db=m Paracrine regulation of the renin-aldosterone system. causal interaction,unassigned 2,0
1.14.99.1 Hypoaldosteronism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16105165&form=6&db=m Hyperkalaemia with cyclooxygenase-2 inhibition and hypoaldosteronism. therapeutic application,unassigned 2,0
1.14.99.1 Hypoglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21414430&form=6&db=m Benzylamine and methylamine, substrates of semicarbazide-sensitive amine oxidase, attenuate inflammatory response induced by lipopolysaccharide. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Hypokalemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28870047&form=6&db=m [Expert consensus for the diagnosis and treatment of patients with Gitelman syndrome]. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Hypoparathyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3801615&form=6&db=m [Mechanisms of thrombocyte aggregation in experimental hypoparathyroidism] ongoing research,unassigned 3,0
1.14.99.1 Hypopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607329&form=6&db=m Enhancement of chemotherapeutic drug-induced apoptosis by a cyclooxygenase-2 inhibitor in hypopharyngeal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Hypopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289707&form=6&db=m Cyclooxygenase 2 promoter-based replication-selective adenoviral vector for hypopharyngeal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Hypopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489236&form=6&db=m Histologic correlation of VEGF and COX-2 expression with tumor size in squamous cell carcinoma of the larynx and hypopharynx. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Hypopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269737&form=6&db=m Selective EP2 and Cox-2 inhibition suppresses cell migration by reversing epithelial-to-mesenchymal transition and Cox-2 overexpression and E-cadherin downregulation are implicated in neck metastasis of hypopharyngeal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Hypoprothrombinemias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005360&form=6&db=m Cyclooxygenase-2 inhibitor celecoxib: a possible cause of gastropathy and hypoprothrombinemia. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1483337&form=6&db=m Intracamerally injected platelet activating factor (PAF) induces marked intraocular inflammatory reactions. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1490622&form=6&db=m Mast cell disease. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1901869&form=6&db=m Opioids and the prostanoid system in the control of cerebral blood flow in hypotensive piglets. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1907113&form=6&db=m Pulmonary vasoregulation by cyclooxygenase metabolites and angiotensin II after hypoperfusion in conscious, pentobarbital-anesthetized, and halothane-anesthetized dogs. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3098746&form=6&db=m Effect of preischemia cyclooxygenase inhibition by zomepirac sodium on reflow, cerebral autoregulation, and EEG recovery in the cat after global ischemia. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115110&form=6&db=m C5a-induced hemodynamic and hematologic changes in the rabbit. Role of cyclooxygenase products and polymorphonuclear leukocytes. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143653&form=6&db=m Lipoxygenase and cyclooxygenase blockade by BW755C prevents endotoxin-induced hypotension but not changes in glucose metabolism. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3459198&form=6&db=m Cardiovascular effects of leukotriene C4 and D4 in the anesthetized and conscious domestic hen. unassigned -
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6509725&form=6&db=m Increased survival of endotoxin-injected dogs treated with methylprednisolone, naloxone, and ibuprofen. therapeutic application,unassigned 4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6681659&form=6&db=m Beagle puppy model of intraventricular hemorrhage: randomized indomethacin prevention trial. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7249895&form=6&db=m Beneficial effect of indomethacin on acid-induced esophagitis in cats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7846692&form=6&db=m Haemodynamic and haematologic effects of Acanthaster planci venom in dogs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8270179&form=6&db=m Phospholipase A2-induced hypotension in the rat and its pharmacological modulation. unassigned -
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8335578&form=6&db=m TNF-alpha and cyclooxygenase metabolites do not modulate C. albicans septic shock with disseminated candidiasis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8379340&form=6&db=m Circulatory responses to endothelin-1 and nitric oxide with special reference to endotoxin shock and nitric oxide inhalation. causal interaction,unassigned 3,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8430938&form=6&db=m Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086. therapeutic application,unassigned 2,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613208&form=6&db=m Platelet activation in carotid sinuses triggers reflex sympathoinhibition and hypotension. therapeutic application,unassigned 1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8835089&form=6&db=m Cardiopulmonary effects of tumor necrosis factor-alpha in the piglet: influence of cyclooxygenase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8854207&form=6&db=m Role of platelet-activating factor and prostanoids in hemodynamic changes in rat experimental endotoxic shock. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9647485&form=6&db=m Effects of inhibitors of the activity of cyclo-oxygenase-2 on the hypotension and multiple organ dysfunction caused by endotoxin: a comparison with dexamethasone. unassigned -
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10781290&form=6&db=m The action of sevoflurane on vascular smooth muscle of isolated mesenteric resistance arteries (part 1): role of endothelium. unassigned -
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10938410&form=6&db=m Induction of PGHS-2 mRNA in response to cerebral hypoperfusion in late-gestation fetal sheep. unassigned -
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11411740&form=6&db=m Hypotensive effect of endothelin-1 in nitric oxide-deprived, hypertensive pregnant rats. therapeutic application,unassigned 1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12144036&form=6&db=m Involvement of COX and NOS induction in the sympatho-activation during sepsis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14563657&form=6&db=m Bovine lactoferrin has a nitric oxide-dependent hypotensive effect in rats. therapeutic application,unassigned 1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15489961&form=6&db=m Effect of fetal hemoglobin on microvascular regulation in sickle transgenic-knockout mice. therapeutic application,unassigned 1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15588656&form=6&db=m San-Huang-Xie-Xin-Tang reduces lipopolysaccharides-induced hypotension and inflammatory mediators. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15590261&form=6&db=m Treatment of refractory mesenteric traction syndrome without cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15894011&form=6&db=m Coronary effects of endothelin-1 and vasopressin during acute hypotension in anesthetized goats. therapeutic application,unassigned 1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16484900&form=6&db=m Ventilation-induced lung injury in rats is associated with organ injury and systemic inflammation that is attenuated by dexamethasone. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18704327&form=6&db=m Prostaglandins inhibit cytochrome P450 4A activity and contribute to endotoxin-induced hypotension in rats via nitric oxide production. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18791491&form=6&db=m HIGH-TIDAL VOLUME VENTILATION AGGRAVATES SEPSIS-INDUCED MULTIORGAN DYSFUNCTION IN A DEXAMETHASONE-INHIBITABLE MANNER. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19297537&form=6&db=m Blockade of PGHS-2 Inhibits the Hypothalamus-Pituitary-Adrenal Axis Response to Cerebral Hypoperfusion in the Sheep Fetus. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19515980&form=6&db=m Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia? therapeutic application,unassigned 1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19896470&form=6&db=m Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. ongoing research,unassigned 1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20456329&form=6&db=m Contribution of Vasoactive Eicosanoids and Nitric Oxide Production to the Effect of Selective Cyclooxygenase-2 Inhibitor, NS-398, on Endotoxin-Induced Hypotension in Rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21217919&form=6&db=m Aspirin-exacerbated respiratory disease: evaluation and management. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21463481&form=6&db=m Piroxicam Reverses Endotoxin-Induced Hypotension in Rats: Contribution of Vasoactive Eicosanoids and Nitric Oxide. causal interaction,unassigned 4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22545970&form=6&db=m Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23442108&form=6&db=m Nitric oxide and ?2-adrenoceptor activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684565&form=6&db=m Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28228357&form=6&db=m Activation of mTOR/I?B-?/NF-?B pathway contributes to LPS-induced hypotension and inflammation in rats. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28949404&form=6&db=m The role of Syk/I?B-?/NF-?B pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock. ongoing research,unassigned 2,0
1.14.99.1 Hypotension, Orthostatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2011722&form=6&db=m [The treatment of orthostatic hypotension with metoclopramide] therapeutic application,unassigned 4,0
1.14.99.1 Hypotension, Orthostatic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7302119&form=6&db=m The treatment of idiopathic orthostatic hypotension: a combined fludrocortisone and flurbiprofen regime. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23369109&form=6&db=m Effects of Hypo- and Hyperthyroidism on Proliferation, Angiogenesis, Apoptosis and Expression of COX-2 in the Corpus Luteum of Female Rats. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Hypothyroidism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29436670&form=6&db=m Hypothyroidism increases cyclooxygenase-2 levels and pro-inflammatory response and decreases cell proliferation and neuroblast differentiation in the hippocampus. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Hypoventilation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7041193&form=6&db=m Hypoventilation and elevation of end-expiratory pressure release a substance which relaxes isolated arteries and disaggregates platelets in the presence of cyclooxygenase inhibitors. therapeutic application,unassigned 1,0
1.14.99.1 Hypoxia, Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7727619&form=6&db=m Effect of cyclooxygenase inhibition on brain cell membrane lipid peroxidation during hypoxia in newborn piglets. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Hypoxia, Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8786646&form=6&db=m Protective effect of KBT-3022, a new cyclooxygenase inhibitor, in cerebral hypoxia and ischemia. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Hypoxia-Ischemia, Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19615346&form=6&db=m The effects of indomethacin on caspases, glutathione level and lipid peroxidation in the newborn rats with hypoxic-ischemic cerebral injury. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Hypoxia-Ischemia, Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20029340&form=6&db=m Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Hypoxia-Ischemia, Brain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29565041&form=6&db=m Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs. causal interaction,unassigned 3,0
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706493&form=6&db=m Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14511257&form=6&db=m Reduced expression of cyclooxygenase (COX) in idiopathic pulmonary fibrosis and sarcoidosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15127973&form=6&db=m Cyclooxygenase-2 is up-regulated in lung parenchyma of chronic obstructive pulmonary disease and down-regulated in idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19487460&form=6&db=m Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis. causal interaction,unassigned 4,0
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501949&form=6&db=m The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21319594&form=6&db=m A haplotype of cyclooxygenase-2 gene is associated with idiopathic pulmonary fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23742950&form=6&db=m Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24473763&form=6&db=m Immunohistochemical and morphometric evaluation of COX 1 and COX-2 in the remodeled lung in idiopathic pulmonary fibrosis and systemic sclerosis. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24652950&form=6&db=m A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. unassigned -
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26122220&form=6&db=m MELATONIN ALLEVIATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN MICE. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26744410&form=6&db=m Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Idiopathic Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34320042&form=6&db=m Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 ikappab kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640307&form=6&db=m Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Ileitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679035&form=6&db=m Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Ileitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33920650&form=6&db=m Unique Regulation of Intestinal Villus Epithelial Cl-/HCO3- Exchange by Cyclooxygenase Pathway Metabolites of Arachidonic Acid in a Mouse Model of Spontaneous Ileitis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10452868&form=6&db=m Products of cyclooxygenase-2 catalysis regulate postoperative bowel motility. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729115&form=6&db=m Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12168503&form=6&db=m Effect of cyclooxygenase inhibitors in postoperative ileus: an experimental study. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631664&form=6&db=m COX-2 dependent inflammation increases spinal Fos expression during rodent postoperative ileus. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12643859&form=6&db=m Differential salutary effects of nonselective and selective COX-2 inhibitors in postoperative ileus in rats. therapeutic application,unassigned 4,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15019933&form=6&db=m The role and interactions of nitric oxide (NO), carbon monoxide (CO), and prostanoids in the pathogenesis of postoperative ileus in rats. unassigned -
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15601422&form=6&db=m Effect of cyclooxygenase-2 inhibitors on gastric emptying and small intestinal transit in humans. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16634783&form=6&db=m Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery. ongoing research,unassigned 3,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17608819&form=6&db=m COX-2 inhibitors and postoperative ileus. therapeutic application,unassigned 4,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18266613&form=6&db=m Alvimopan and COX-2 inhibition reverse opioid and inflammatory components of postoperative ileus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18402645&form=6&db=m Mentation on the immunological modulation of gastrointestinal motility. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438116&form=6&db=m Differential sensitization of afferent neuronal pathways during postoperative ileus in the mouse jejunum. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19464805&form=6&db=m Gastric and small bowel ileus after severe burn in rats: The effect of cyclooxygenase-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19657050&form=6&db=m PPAR{gamma} Activation Alleviates Postoperative Ileus in Mice by Inhibition of Egr-1 Expression and Its Downstream Target Genes. causal interaction,unassigned 1,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19694636&form=6&db=m Clinical Trial: The impact of cyclooxygenase inhibitors on gastrointestinal recovery after major surgery: a randomised double blind controlled trial of Celecoxib or Diclofenac versus placebo. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808045&form=6&db=m Emerging role of cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions. causal interaction,unassigned 4,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20887356&form=6&db=m The impact of cyclooxygenase inhibition on duodenal motility and mucosal alkaline secretion in anaesthetised rats. causal interaction,unassigned 1,0
1.14.99.1 Ileus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22251854&form=6&db=m The selective cyclooxygenase-2 inhibitor parecoxib markedly improves the ability of the duodenum to regulate luminal hypertonicity in anaesthetized rats. therapeutic application,unassigned 4,0
1.14.99.1 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7956720&form=6&db=m Prevention of spontaneous polyarthritis in NZB/KN mice by treatment with a novel thiazole derivative, SM-8849. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24710938&form=6&db=m Cyclooxygenase-2 blockade inhibits accumulation and function of myeloid-derived suppressor cells and restores T cell response after traumatic stress. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Immune System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30668431&form=6&db=m Anti-inflammation action of xanthones from Swertia chirayita by regulating COX-2/NF-?B/MAPKs/Akt signaling pathways in RAW 264.7 macrophage cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2154040&form=6&db=m Arachidonic acid metabolite production following focal cerebral ischemia: time course and effect of meclofenamate. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2728047&form=6&db=m Effect of indomethacin and a free radical scavenger on cerebral blood flow and edema after cerebral artery occlusion in cats. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8371169&form=6&db=m Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898713&form=6&db=m Cyclo-oxygenase-2 messenger RNA induction in focal cerebral ischemia. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10584847&form=6&db=m Induction of cyclooxygenase-2 messenger RNA after transient and permanent middle cerebral artery occlusion in rats: comparison with c-fos messenger RNA by using in situ hybridization. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11740205&form=6&db=m Increased susceptibility to ischemic brain injury in cyclooxygenase-1-deficient mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11991232&form=6&db=m Enhanced protection by melatonin and meloxicam combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12213634&form=6&db=m Cyclooxygenase-1 gene knockout does not alter middle cerebral artery occlusion in a mouse stroke model. therapeutic application,unassigned 1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891667&form=6&db=m Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14769366&form=6&db=m Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15548426&form=6&db=m Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo. therapeutic application,unassigned 4,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15656909&form=6&db=m Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16567054&form=6&db=m Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16770015&form=6&db=m Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17150094&form=6&db=m Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response? causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19446533&form=6&db=m Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236388&form=6&db=m The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21635885&form=6&db=m Protective effect of Etoricoxib against middle cerebral artery occlusion induced transient focal cerebral ischemia in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21843661&form=6&db=m Microglia and cyclooxygenase-2: Possible therapeutic targets of progesterone for stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22669728&form=6&db=m Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-?B in middle cerebral artery occlusion rat model. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23609497&form=6&db=m Apobec-1 increases cyclooxygenase-2 and aggravates injury in oxygen-deprived neurogenic cells and middle cerebral artery occlusion rats. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23989686&form=6&db=m Anti-Inflammatory Effects of Total Isoflavones from Pueraria lobata on Cerebral Ischemia in Rats. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25240714&form=6&db=m Perillyl alcohol improves functional and histological outcomes against ischemia-reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2 and NF-?B in middle cerebral artery occlusion rats. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26503024&form=6&db=m Cyclooxygenase-2 and Prostaglandin E2 are Associated with Middle Cerebral Artery Occlusion and Hemorrhage in Patients with Moyamoya Disease. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30156477&form=6&db=m Resveratrol attenuates brain damage in permanent focal cerebral ischemia via activation of PI3K/Akt signaling pathway in rats. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973660&form=6&db=m Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33184783&form=6&db=m Celecoxib-Dependent Neuroprotection in a Rat Model of Transient Middle Cerebral Artery Occlusion (tMCAO) Involves Modifications in Unfolded Protein Response (UPR) and Proteasome. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33889074&form=6&db=m Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1282202&form=6&db=m Cytokine-mediated regulation of monocyte/macrophage cytotoxicity in human immunodeficiency virus-1 infection. therapeutic application,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2104939&form=6&db=m Immunoprotective effects of cyclooxygenase inhibition in patients with major surgical trauma. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119789&form=6&db=m The prophylactic use of cyclooxygenase inhibitors in recurrent herpes simplex infections. therapeutic application,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3464235&form=6&db=m The effect of indomethacin on muscle and liver protein synthesis and on whole-body protein degradation during abdominal sepsis in the rat. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6330977&form=6&db=m Reversible restriction of vesicular stomatitis virus in permissive cells treated with inhibitors of prostaglandin biosynthesis. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6333432&form=6&db=m Indomethacin enhances the proliferation of mitogen-stimulated T lymphocytes of homosexual males with persistent generalized lymphadenopathy. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6419199&form=6&db=m A reexamination of the role of oxygen in retrolental fibroplasia. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6821089&form=6&db=m Prostaglandin synthetase inhibitors in primary herpes infections. therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7495363&form=6&db=m Experimental murine schistosomiasis: reduced hepatic morbidity after pre- and/or post-infection treatment with ibuprofen or diclofenac sodium. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7692858&form=6&db=m Association between reactive arthritis and antecedent infection with Shigella flexneri carrying a 2-Md plasmid and encoding an HLA-B27 mimetic epitope. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383332&form=6&db=m Poxvirus-induced alteration of arachidonate metabolism. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8510075&form=6&db=m Immunomodulation of cellular cytotoxicity to herpes simplex virus infection in pregnancy by inhibition of eicosanoid metabolism. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8698486&form=6&db=m Candida albicans stimulates cytokine production and leukocyte adhesion molecule expression by endothelial cells. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8826112&form=6&db=m Histochemical investigations of the biochemical defence mechanism in experimental trichinellosis: II. prostaglandin synthase activity. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8832221&form=6&db=m Evidence for tumor necrosis factor alpha as a mediator of the toxicity of a cyclooxygenase inhibitor in Gram-negative sepsis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8915881&form=6&db=m Cascade of fever production in mice infected with influenza virus. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9007013&form=6&db=m Characterization of the stable maintenance of the Shigella flexneri plasmid pHS-2. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9218506&form=6&db=m Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9529115&form=6&db=m Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin H synthase 2 expression and prostaglandin E2 and F2alpha production. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9715175&form=6&db=m Cyclooxygenase-2 inhibitor NS-398 improves survival and restores leukocyte counts in burn infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888205&form=6&db=m Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10235197&form=6&db=m Cyclooxygenase-2 expression in gastric antral mucosa before and after eradication of Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10348815&form=6&db=m Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10405195&form=6&db=m Deregulation of cyclooxygenase and nitric oxide synthase gene expression in the inflammatory cascade triggered by experimental group B streptococcal meningitis in the newborn brain and cerebral microvessels. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10482283&form=6&db=m Expression of COX-1, COX-2, and inducible nitric oxide synthase protein in human gastric antrum with Helicobacter pylori infection. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10488055&form=6&db=m Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10608532&form=6&db=m Burn injury with infection alters prostaglandin E2 synthesis and metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807888&form=6&db=m Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10811000&form=6&db=m Induction of cyclooxygenase-2 by human monocytes exposed to group B streptococci. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884377&form=6&db=m Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10899936&form=6&db=m Induction of cyclooxygenase-2 by overexpression of the human catalase gene in cerebral microvascular endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10957885&form=6&db=m Serologic and histopathologic study of Chlamydia pneumoniae infection in atherosclerosis: a possible pathogenetic mechanism of atherosclerosis induced by Chlamydia pneumoniae. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11020068&form=6&db=m Effects of treatments with cyclooxygenase inhibitors on chickens infected with Eimeria acervulina. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11033048&form=6&db=m Helicobacter pylori infection and gastrin and cyclooxygenase expression in gastric and colorectal malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11040354&form=6&db=m Nonsteroidal anti-inflammatory drug-induced acute gastric injury in Helicobacter pylori gastritis in Mongolian gerbils. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11069240&form=6&db=m Infection and activation of airway epithelial cells by Chlamydia pneumoniae. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11076710&form=6&db=m Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11085935&form=6&db=m Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090259&form=6&db=m Expression of cyclooxygenase-2 and nitrotyrosine in human gastric mucosa before and after Helicobacter pylori eradication. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11148436&form=6&db=m Expression and cellular localization of COX-1 and -2 in Helicobacter pylori gastritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11176123&form=6&db=m Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192946&form=6&db=m Helicobacter pylori, gastrin and cyclooxygenases in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11208460&form=6&db=m Helicobacter pylori, gastrin and cyclooxygenase-2 in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11227686&form=6&db=m The expression of cyclooxygenase and the production of prostaglandin E2 in neutrophils after burn injury and infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11231344&form=6&db=m Escherichia coli-induced inducible nitric oxide synthase and cyclooxygenase expression in the mouse bladder and kidney. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245439&form=6&db=m Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: mediation through cyclooxygenase-independent pathways. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11254616&form=6&db=m Analysis of chicken mucosal immune response to Eimeria tenella and Eimeria maxima infection by quantitative reverse transcription-PCR. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11258572&form=6&db=m Upregulated cyclooxygenase-2 inhibits apoptosis of human gastric epithelial cells infected with Helicobacter pylori. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11268352&form=6&db=m Control of salivary secretion by nitric oxide and its role in neuroimmunomodulation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292761&form=6&db=m Amebic infection in the human colon induces cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11298294&form=6&db=m Leishmania donovani-induced macrophages cyclooxygenase-2 and prostaglandin E2 synthesis. therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375954&form=6&db=m Role of immunologic factors and cyclooxygenase 2 in persistent postinfective enteric muscle dysfunction in mice. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11380326&form=6&db=m Involvement of cyclooxygenase-2 in hyperplastic gastritis induced by Helicobacter pylori infection in C57BL/6 mice. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11395920&form=6&db=m The role of n-3 fatty acids in gestation and parturition. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11424315&form=6&db=m Effects of cyclooxygenase-2 inhibitor on gastric acid secretion in Helicobacter pylori-infected C57BL/6 mice. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11440919&form=6&db=m Inhibition of salivary secretion by lipopolysaccharide: possible role of prostaglandins. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11444469&form=6&db=m Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithelial cells: mediation by nuclear factor-kappaB. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11447186&form=6&db=m Effects of nonsteroidal anti-inflammatory drugs on Helicobacter pylori-infected gastric mucosae of mice: apoptosis, cell proliferation, and inflammatory activity. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489969&form=6&db=m Human cytomegalovirus circumvents NF-kappa B dependence in retinal pigment epithelial cells. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11515678&form=6&db=m Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11519793&form=6&db=m Implication of gastrin in cyclooxygenase-2 expression in Helicobacter pylori infected gastric ulceration. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11535962&form=6&db=m Cancerogenesis in Helicobacter pylori infected stomach--role of growth factors, apoptosis and cyclooxygenases. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11598092&form=6&db=m Inhibition of attaching and effacing lesion formation following enteropathogenic Escherichia coli and Shiga toxin-producing E. coli infection. therapeutic application,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687726&form=6&db=m Molecular basis of colorectal cancer - role of gastrin and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11705951&form=6&db=m Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819707&form=6&db=m Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection, histological types and staging. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11832369&form=6&db=m COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11850726&form=6&db=m Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with DeltaE1, DeltaE3 recombinant adenovirus vectors. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11865407&form=6&db=m Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867761&form=6&db=m Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11886470&form=6&db=m Effects of selective cyclooxygenase-2 inhibitor and non-selective NSAIDs on Helicobacter pylori-induced gastritis in Mongolian gerbils. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11910358&form=6&db=m Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11936620&form=6&db=m Selective inhibition of COX-2 is beneficial to mice infected intranasally with VSV. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943943&form=6&db=m Cyclooxygenase-2 expression in early gastric cancer, intestinal metaplasia and Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966538&form=6&db=m Persistent increase in myofibroblasts in Helicobacter heilmannii-infected mice but not in Helicobacter pylori-infected Mongolian gerbils: colocalization of COX-2 and bFGF immunoreactivity. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12007881&form=6&db=m Bluetongue virus-induced activation of primary bovine lung microvascular endothelial cells. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009531&form=6&db=m Theiler's virus infection induces the expression of cyclooxygenase-2 in murine astrocytes: inhibition by the anti-inflammatory cytokines interleukin-4 and interleukin-10. therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12014312&form=6&db=m Gastric MALT-lymphoma, gastrin and cyclooxygenases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12068008&form=6&db=m Activation of monocyte cyclooxygenase-2 gene expression by human herpesvirus 6. Role for cyclic AMP-responsive element-binding protein and activator protein-1. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12069531&form=6&db=m The role of endothelial cell-derived inflammatory and vasoactive mediators in the pathogenesis of bluetongue. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086398&form=6&db=m Oxidant-sensitive transcription factor and cyclooxygenase-2 by Helicobacter pylori stimulation in human gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12113843&form=6&db=m Fatal hyperkalemia related to combined therapy with a COX-2 inhibitor, ACE inhibitor and potassium rich diet. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126507&form=6&db=m [Association between Helicobacter pylori cagA strain infection and expression of cyclooxygenase 2 in gastric carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12163100&form=6&db=m Impact of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on gastric ulcerogenesis in experimental animals and in humans. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173384&form=6&db=m Expression of cyclooxygenase-2 in primary and remnant gastric carcinoma: comparing it with p53 accumulation, Helicobacter pylori infection, and vascular endothelial growth factor expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12193735&form=6&db=m The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12218957&form=6&db=m Interaction of Helicobacter pylori (Hp) and nonsteroidal anti-inflammatory drugs (NSAID) on gastric mucosa and risk of ulcerations. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12239223&form=6&db=m Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12352459&form=6&db=m Prostaglandin E2 production and cyclooxygenase-2 induction in human urinary tract infections and bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12353842&form=6&db=m Progastrin and cyclooxygenase-2 in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12478407&form=6&db=m Induction of cyclo-oxygenase-2 by acute liver allograft rejection and cytomegalovirus infection in the rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12511556&form=6&db=m Cyclooxygenase-2 inhibits tumor necrosis factor alpha-mediated apoptosis in renal glomerular mesangial cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12517975&form=6&db=m Regulation of cyclooxygenase-2 expression by macrophages in response to double-stranded RNA and viral infection. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12532440&form=6&db=m Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12538084&form=6&db=m Effect of H. pylori infection on the expression of cyclooxygenase-2 in human gastric mucosa. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12542979&form=6&db=m Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible? causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12584888&form=6&db=m Prostacyclin and hormone levels in patients with symptoms of miscarriage and infection. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616426&form=6&db=m Expression of cyclooxygenases in Helicobacter pylori gastritis and residual gastritis after distal gastrectomy. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12654832&form=6&db=m Salmonella infection induces a hypersecretory phenotype in human intestinal xenografts by inducing cyclooxygenase 2. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12721317&form=6&db=m Aspirin inhibits Chlamydia pneumoniae-induced NF-kappa B activation, cyclo-oxygenase-2 expression and prostaglandin E2 synthesis and attenuates chlamydial growth. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12823157&form=6&db=m Effect of cyclooxygenase-2 inhibition on human Helicobacter pylori gastritis: mechanisms underlying gastrointestinal safety and implications for cancer chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12856313&form=6&db=m Involvement of prostaglandins in the immunosuppression occurring during experimental infection by Paracoccidioides brasiliensis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12864814&form=6&db=m Infection of human urethral epithelium with Neisseria gonorrhoeae elicits an upregulation of host anti-apoptotic factors and protects cells from staurosporine-induced apoptosis. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883469&form=6&db=m H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPAR gamma and impaired apoptosis in gastric carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12956746&form=6&db=m Role of mitogen-activated protein kinases in influenza virus induction of prostaglandin E2 from arachidonic acid in bronchial epithelial cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958020&form=6&db=m Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529402&form=6&db=m COX-2 inhibition, H. pylori infection and the risk of gastrointestinal complications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530307&form=6&db=m Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14531897&form=6&db=m Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552705&form=6&db=m Transcriptional regulation of cyclo-oxygenase expression: three pillars of control. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14592546&form=6&db=m COX-1 and COX-3 inhibitors. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14610197&form=6&db=m COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14614005&form=6&db=m Higher gastric cycloxygenase-2 expression and precancerous change in Helicobacter pylori-infected relatives of gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14627349&form=6&db=m Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14705819&form=6&db=m Cyclooxygenase expression during Helicobacter pylori infection in Mongolian gerbils. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716842&form=6&db=m Expression of COX-2 proteins in gastric mucosal lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14733733&form=6&db=m The role and regulation of COX-2 during viral infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14741133&form=6&db=m Expression of immune response genes in rainbow trout skin induced by Gyrodactylus derjavini infections. therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991895&form=6&db=m Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15022477&form=6&db=m [Research on relationships of gastric cancer with serum trace elements, Helicobacter pylori and COX-2 in gastric tissue] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15038104&form=6&db=m [Are COX-2 inhibitors truly able to prevent NSAIDs-associated ulcer?] causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15064999&form=6&db=m Histopathology and expression of Ki-67 and cyclooxygenase-2 in childhood Helicobacter pylori gastritis. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15086604&form=6&db=m Expression of cyclooxygenase-2 in cholangiocarcinoma: correlation with clinicopathological features and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172219&form=6&db=m Entamoeba histolytica: induction of cyclooxygenase-2 expression during amoebic liver abscess formation in hamsters (Mesocricetus auratus). causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15232145&form=6&db=m Expression of cyclooxygenase-2 and nitric oxide synthase 2 in swine ulcerative colitis caused by Salmonella typhimurium. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240110&form=6&db=m Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE2 and MMP-1 expression. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15258190&form=6&db=m The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2. therapeutic application,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15283266&form=6&db=m [Intra-cellular signal pathway and synthesis of prostaglandin E2 during invasion of macrophage by Toxoplasma gondii] ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298601&form=6&db=m Sex differences in mucosal response to Helicobacter pylori infection in the stomach and variations in interleukin-8, COX-2 and trefoil factor family 1 gene expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15334675&form=6&db=m Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15351039&form=6&db=m Production of prostaglandin E2 in monocytes stimulated in vitro by Chlamydia trachomatis, Chlamydophila pneumoniae, and Mycoplasma fermentans. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362790&form=6&db=m Effect of H. pylori on COX-2 expression in gastric remnant after distal gastrectomy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15371919&form=6&db=m Influence of gastritis on cyclooxygenase-2 expression before and after eradication of Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15479690&form=6&db=m Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501771&form=6&db=m Gonococcal porin IB activates NF-kappaB in human urethral epithelium and increases the expression of host antiapoptotic factors. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15507640&form=6&db=m A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15542648&form=6&db=m Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15545053&form=6&db=m Circulating levels of cyclooxygenase metabolites in experimental Trypanosoma cruzi infections. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15557075&form=6&db=m Expression of nitric oxide synthase 2 and cyclooxygenase-2 in swine experimentally infected with Actinobacillus pleuropneumoniae. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15557607&form=6&db=m Salmonella enterica serovar Typhimurium infection induces cyclooxygenase 2 expression in macrophages: involvement of Salmonella pathogenicity island 2. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585646&form=6&db=m the selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15599211&form=6&db=m The interaction of H. pylori infection and NSAIDs in cyclooxygenase-2 mRNA expression in gastric antral, corpus mucosa, and gastric ulcer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15640153&form=6&db=m Matrix metalloproteinase secretion by gastric epithelial cells is regulated by E prostaglandins and MAPKs. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767259&form=6&db=m Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15778400&form=6&db=m Respiratory syncytial virus (RSV) infection induces cyclooxygenase 2: a potential target for RSV therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809909&form=6&db=m Effect of heptitis C virus core protein on cellular gene expression: specific inhibition of cyclooxygenase 2. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823615&form=6&db=m Localization of prostaglandin H synthase, prostaglandin dehydrogenase, corticotropin releasing hormone and glucocorticoid receptor in rhesus monkey fetal membranes with labor and in the presence of infection. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15864778&form=6&db=m Depletion of immature B cells during Trypanosoma cruzi infection: involvement of myeloid cells and the cyclooxygenase pathway. ongoing research,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15893277&form=6&db=m Implications of corpus gastritis, atrophy and cyclooxygenase in the development of gastric erosions after curing Helicobacter pylori infection. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15929167&form=6&db=m Helicobacter pylori promote gastric cancer cells invasion through a NF-kappaB and COX-2-mediated pathway. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963597&form=6&db=m Recombinant HBsAg inhibits LPS-induced COX-2 expression and IL-18 production by interfering with the NFkappaB pathway in a human monocytic cell line, THP-1. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15997236&form=6&db=m Selective inhibition of inhibitory kappa B kinase-beta abrogates induction of nitric oxide synthase in lipopolysaccharide-stimulated rat aortic smooth muscle cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16009364&form=6&db=m Inducible cyclooxygenase released prostaglandin mediates immunosuppression in acute phase of experimental Trypanosoma cruzi infection. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16012943&form=6&db=m Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16036795&form=6&db=m Up-regulation of astrocyte cyclooxygenase-2, CCAAT/enhancer-binding protein-homology protein, glucose-related protein 78, eukaryotic initiation factor 2 alpha, and c-Jun N-terminal kinase by a neurovirulent murine retrovirus. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051851&form=6&db=m Role of inflammatory cytokine-induced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113275&form=6&db=m Salmonella pathogenicity island 2-dependent expression of suppressor of cytokine signaling 3 in macrophages. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16153673&form=6&db=m RSV-induced prostaglandin E2 production occurs via cPLA2 activation: role in viral replication. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16183115&form=6&db=m IL-1beta treatment does not co-ordinately up-regulate mPGES-1 and COX-2 mRNA expression, but results in higher degree of cellular and intracellular co-localization of their immunoreactive proteins in human placenta trophoblast cells. ongoing research,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213894&form=6&db=m Synergistic tumoricidal effect between celecoxib and adenoviral-mediated delivery of mda-7 in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247189&form=6&db=m Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16272346&form=6&db=m Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16297651&form=6&db=m COX-2 inhibition affects growth rate of Chlamydia muridarum within epithelial cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16388870&form=6&db=m Infectious bursal disease virus infection induces macrophage activation via p38 MAPK and NF-kappaB pathways. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16394872&form=6&db=m Preferential expression of cyclooxygenase-2 in colonic-phenotype of gastric intestinal metaplasia: association with helicobacter pylori and gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16423085&form=6&db=m Effect of Probiotics and Triple Eradication Therapy on the Cyclooxygenase (COX)-2 Expression, Apoptosis, and Functional Gastric Mucosal Impairment in Helicobacter pylori-Infected Mongolian Gerbils. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16481516&form=6&db=m Potential roles for regulatory oxygenases in rickettsial pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16493068&form=6&db=m Mycobacterium bovis Bacillus Calmette-Guerin Induces TLR2-Mediated Formation of Lipid Bodies: Intracellular Domains for Eicosanoid Synthesis In Vivo. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16496341&form=6&db=m Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) gene. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516308&form=6&db=m The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: implications for multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16518767&form=6&db=m Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Gastric Inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16604526&form=6&db=m Transgenic mouse for conditional, tissue-specific Cox-2 overexpression. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16611284&form=6&db=m Effects of low-dose aspirin on gastric erosions, cyclooxygenase expression and mucosal prostaglandin-E do not depend on Helicobacter pylori infection. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622456&form=6&db=m RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677165&form=6&db=m Influences of Helicobacter pylori on cyclooxygenase-2 expression and prostaglandinE2 synthesis in rat gastric epithelial cells in vitro. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16678181&form=6&db=m Immunopathogenesis of cerebral malaria. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16760271&form=6&db=m Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762620&form=6&db=m Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese population. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16775340&form=6&db=m Cyclooxygenase 2 induced by Kaposi's sarcoma-associated herpesvirus early during in vitro infection of target cells plays a role in the maintenance of latent viral gene expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16782382&form=6&db=m Human cytomegalovirus induced cyclooxygenase-2 in human retinal pigment epithelial cells augments viral replication through a prostaglandin pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16800815&form=6&db=m Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16804960&form=6&db=m Interaction or relationship between Helicobacter pylori and non-steroidal anti-inflammatory drugs in upper gastrointestinal diseases. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835706&form=6&db=m Influenza ("Bird Flu"), inflammation and anti-inflammatory/analgesic drugs. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16882323&form=6&db=m Helicobacter pylori eradication therapy on histologic change in the distal esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900533&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16914119&form=6&db=m The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE(2) release in murine brain-derived endothelial cells following Theiler's virus infection. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16920983&form=6&db=m Role of MAPK in the regulation of double-stranded RNA- and encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16926398&form=6&db=m Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16930845&form=6&db=m Dynamics of transcription of immunomodulatory genes in endothelial cells infected with different coccidian parasites. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949912&form=6&db=m Infrequent COX-2 expression due to promoter hypermethylation in gastric cancers in Dalian, China. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17033105&form=6&db=m Gastric cancer and Helicobacter pylori infection. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17086892&form=6&db=m Influence of COX-2 and local cytokine expressions in gastric ulcer mucosa by H. pylori and NSAID. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17199977&form=6&db=m [Expression of peroxisome proliferators-activated receptor-gamma and cyclooxygenase-2 in Helicobacter pylori infection-associated diseases and significance thereof] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17203475&form=6&db=m Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17222216&form=6&db=m Expression of cyclooxygenase-2, alpha 1-acid-glycoprotein and inducible nitric oxide synthase in the developing lesions of murine leprosy. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17241301&form=6&db=m 5-LOX inhibitor modulates the inflammatory responses provoked by Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17330822&form=6&db=m Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17492998&form=6&db=m Enhanced activation of cyclooxygenase-2 downregulates Th1 signaling pathway in Helicobacter pylori-infected human gastric mucosa. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17555580&form=6&db=m Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,2
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17641100&form=6&db=m Bovine herpesvirus 4 is tropic for bovine endometrial cells and modulates endocrine function. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671743&form=6&db=m Association between genetic polymorphisms in the cyclooxygenase-1 gene promoter and peptic ulcers in Japan. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17693978&form=6&db=m Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17727457&form=6&db=m Helicobacter and gastric malignancies. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17763946&form=6&db=m Neuronal cyclooxygenase-2 activity and prostaglandins PGE2, PGD2, and PGF2 alpha exacerbate hypoxic neuronal injury in neuron-enriched primary culture. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785856&form=6&db=m Adenovirus type 5 exerts multiple effects on the expression and activity of cytosolic phospholipase A2, cyclooxygenase-2, and prostaglandin synthesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17845691&form=6&db=m Cyclooxygenase-2 expression in chronic hepatitis C and the effect of interferon alpha treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17927697&form=6&db=m Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1). causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934641&form=6&db=m Over-expression of cyclooxygenase-2 in endoscopic biopsies of ectopic gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17964630&form=6&db=m NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18031539&form=6&db=m Effects of cyclooxygenase inhibitors on parasite burden, anemia and oxidative stress in murine Trypanosoma cruzi infection. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18092051&form=6&db=m Expression of cyclooxygenase-2 and transforming growth factor-beta1 in HCV-induced chronic liver disease and hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097055&form=6&db=m Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18237405&form=6&db=m Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18279196&form=6&db=m Expression of COX-1, COX-2, and PPAR-gamma in the gastric mucosa of children with Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18283644&form=6&db=m Synergistic upregulation of inducible nitric oxide synthase and cyclooxygenase-2 in gastric mucosa of Mongolian gerbils by a high-salt diet and Helicobacter pylori infection. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18330937&form=6&db=m Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: A study from northern India. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338835&form=6&db=m The cyclo-oxygenase 2 promoter is induced in nontarget cells following adenovirus infection, but an AU-rich 3'-untranslated region destabilization element can increase specificity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18344086&form=6&db=m [Protein expression and clinical significance of cyclooxygenase 2 and nuclear factor kappa B in gastric mucosa-associated lymphoid tissue lymphoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438879&form=6&db=m Arthritis develops but fails to resolve during inhibition of cyclooxygenase 2 in a murine model of Lyme disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462890&form=6&db=m Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18524544&form=6&db=m Selective cyclooxygenase inhibitors prevent the growth of Chlamydia pneumoniae in HL cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18582172&form=6&db=m Genetic polymorphisms of cyclooxygenase-1 (COX-1) are associated with functional dyspepsia in Japanese women. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18584518&form=6&db=m Short-term/low-dose aspirin-induced duodenal erosions are not dependent on Helicobacter pylori infection, cyclooxygenase expression and prostaglandin E2 levels. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18692980&form=6&db=m Blood COX-2 and PGES gene transcription during the peripartum period of dairy cows with normal puerperium or with uterine infection. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18765718&form=6&db=m Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18783518&form=6&db=m Helicobacter pylori and non-malignant diseases. therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18985541&form=6&db=m Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18987470&form=6&db=m Celecoxib inhibits apurinic/apyrimidinic endonuclease-1 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017360&form=6&db=m Cyclooxygenase-2/Carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19077474&form=6&db=m [The change of cyclooxygenase-2 and inducible nitric oxide synthase in the gastric mucosa one year after eradication of Helicobacter pylori] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19118057&form=6&db=m Cyclooxygenase-2 is an independent prognostic factor in gastric carcinoma patients receiving adjuvant chemotherapy and is not associated with EBV infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19120890&form=6&db=m Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: its relation to vascular endothelial growth factor and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19140872&form=6&db=m Inhibition of TNF-alpha-induced cyclooxygenase-2 expression by Mycobacterium bovis BCG in human alveolar epithelial A549 cells. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173907&form=6&db=m [Correlation of Helicobacter pylori infection with the expression of COX-2 and EGFR and VEGF in human gastric carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19228814&form=6&db=m M. bovis BCG induced expression of COX-2 involves nitric oxide-dependent and -independent signaling pathways. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19317916&form=6&db=m Identification of novel cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19438652&form=6&db=m Rickettsia rickettsii infection of human pulmonary microvascular endothelial cells: modulation of cyclooxygenase-2 expression. ongoing research,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19458541&form=6&db=m OmpA is the critical component for Escherichia coli invasion-induced astrocyte activation. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19463183&form=6&db=m Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19543553&form=6&db=m Cyclooxygenase-2 Inhibition Enhances Activation of T Helper Type 1 Responses During Salmonella Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19628016&form=6&db=m Understanding the molecular mechanism of blood-brain barrier damage in an experimental model of Japanese encephalitis: Correlation with minocycline administration as a therapeutic agent. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19682802&form=6&db=m Neonatal bacterial infection alters fever to live and simulated infections in adulthood. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19694746&form=6&db=m Gastric mucosal injury in systemic lupus erythematosus patients receiving pulse methylprednisolone therapy. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19726335&form=6&db=m [Silencing of COX-2 in nasopharyngeal carcinoma cells with a shRNAmir lentivirus vector] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19730383&form=6&db=m The relationship between HPV16 and expression of cyclooxygenase-2, P53 and their prognostic roles in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19748535&form=6&db=m Cellular signals involved in cyclooxygenase-2 expression induced by human cytomegalovirus. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19797925&form=6&db=m Cross-talk between inducible nitric oxide synthase and cyclooxygenase in Helicobacter-pylori-induced gastritis. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19826177&form=6&db=m Helicobacter pylori infection in gastric cancerogenesis. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843949&form=6&db=m Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19862774&form=6&db=m Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation. therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19889076&form=6&db=m Host single nucleotide polymorphisms of MMP-9 -1562/TIMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19941994&form=6&db=m Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19954066&form=6&db=m [Association between promoter methylation of cyclooxygenase-2 and expression, and precancerous gastric lesions in a high-risk population] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20121401&form=6&db=m Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20136974&form=6&db=m Anti-inflammatory actions of probiotics through activating suppressor of cytokine signaling (SOCS) expression and signaling in Helicobacter pylori infection: a novel mechanism. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20144201&form=6&db=m Chronic infection during placental malaria is associated with up-regulation of cycloxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20169190&form=6&db=m Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20236388&form=6&db=m The cyclooxygenase site, but not the peroxidase site of cyclooxygenase-2 is required for neurotoxicity in hypoxic and ischemic injury. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20364406&form=6&db=m Study on the association of COX-2 genetic polymorphisms with risk of gastric cancer in high incidence Hexi area of Gansu province in China. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20385756&form=6&db=m Rickettsia rickettsii infection of human macrovascular and microvascular endothelial cells reveals activation of both common and cell type-specific host response mechanisms. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20492336&form=6&db=m Correlations among Helicobacter pylori infection and the expression of cyclooxygenase-2 and vascular endothelial growth factor in gastric mucosa with intestinal metaplasia or dysplasia. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20606163&form=6&db=m Priming innate immune responses to infection by cyclooxygenase inhibition kills antibiotic-susceptible and -resistant bacteria. therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20644176&form=6&db=m Inducible cyclooxygenase released prostaglandin E2 modulates the severity of infection caused by Streptococcus pyogenes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717114&form=6&db=m Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20880066&form=6&db=m Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20934379&form=6&db=m Chromatin and DNA methylation dynamics of Helicobacter pylori-induced COX-2 activation. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939988&form=6&db=m [Chinese herbal medicine Jianpi Jiedu Formula down-regulates the expression of vascular endothelial growth factor in human gastric cell line MKN45 induced by Helicobacter pylori by inhibiting cyclooxygenase-2.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20943963&form=6&db=m NFAT AND CREB REGULATE KAPOSI'S SARCOMA ASSOCIATED HERPES VIRUS (KSHV) INDUCED CYCLOOXYGENASE-2 (COX-2). causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21241401&form=6&db=m Increased COX-2 Expression in Human Vaginal Epithelial Cells Exposed to Nonoxynol-9, a Vaginal Contraceptive Microbicide that Failed to Protect Women from HIV-1 Infection. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360914&form=6&db=m [Effect of Helicobacter pylori infection on proliferation and apoptosis in stomach antrum in smoking patients]. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21490090&form=6&db=m An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21538574&form=6&db=m Interaction of Cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21761591&form=6&db=m Antiviral activity of a selective COX-2 inhibitor NS-398 on avian influenza H5N1 infection. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21798291&form=6&db=m Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21812267&form=6&db=m [Effect of jianpi jiedu recipe on microvessel density and cyclooxygenm-2 expression in Heliobacter pylori induced gastric cancer]. ongoing research,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21849808&form=6&db=m Inactivation of COX-2, HMLH1 and CDKN2A Gene by Promoter Methylation in Gastric Cancer: Relationship with Histological Subtype, Tumor Location and Helicobacter pylori Genotype. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21884885&form=6&db=m Bioactive lipids in Trypanosoma cruzi infection. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21917649&form=6&db=m Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957142&form=6&db=m Hepatitis B virus induces a novel inflammation network involving three inflammatory factors, IL-29, IL-8, and cyclooxygenase-2. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21958410&form=6&db=m Immune-related genes expression profile in orange-spotted grouper during exposure to Cryptocaryon irritans. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22135046&form=6&db=m The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22138502&form=6&db=m Mycobacterium indicus pranii downregulates MMP-9 and iNOS through COX-2 dependent and TNF-? independent pathway in mouse peritoneal macrophages in vitro. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22154837&form=6&db=m ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signaling. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203573&form=6&db=m IL-10 suppresses bactericidal response of macrophages against Salmonella Typhimurium. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203921&form=6&db=m Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesions. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22235849&form=6&db=m Induction of Cyclooxygenase (COX)-2 in Human Vaginal Epithelial Cells in Response to TLR ligands and TNF-? diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22244476&form=6&db=m Effect of experimental genital mycoplasmosis on gene expression in the fetal brain. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22522044&form=6&db=m Regulation of inducible heme oxygenase and cyclooxygenase isozymes in a mouse model of spotted fever group rickettsiosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534090&form=6&db=m Production of prostaglandin E? in response to infection with modified vaccinia Ankara virus. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553989&form=6&db=m Identification by DNA microarray of genes involved in Candida albicans-treated gingival epithelial cells. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22570607&form=6&db=m Macrophage activation associated with chronic murine cytomegalovirus infection results in more severe experimental choroidal neovascularization. ongoing research,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22577245&form=6&db=m Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22669511&form=6&db=m Involvement of p38 MAPK-dependent activator protein (AP-1) activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori by ghrelin. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22828789&form=6&db=m ASC-dependent RIP2 Kinase Regulates Reduced PGE2 Production in Chronic Periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22927813&form=6&db=m A Novel Virulence Strategy for Pseudomonas aeruginosa Mediated by an Autotransporter with Arginine-Specific Aminopeptidase Activity. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22962522&form=6&db=m Revaprazan, a novel acid pump antagonist, exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23321929&form=6&db=m Cyclooxygenase-2 Generates the Endogenous Mutagen trans-4-Hydroxy-2-nonenal in Enterococcus faecalis-Infected Macrophages. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23327006&form=6&db=m The characteristics of the expression of heat shock proteins and COX-2 in the liver of hamsters infected with Clonorchis sinensis, and the change of endocrine hormones and cytokines. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23409199&form=6&db=m Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23437263&form=6&db=m The Effects of Oral and Enteric Campylobacter concisus Strains on Expression of TLR4, MD-2, TLR2, TLR5 and COX-2 in HT-29 Cells. ongoing research,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23469054&form=6&db=m Aqueous Extract of the Edible Gracilaria tenuistipitata Inhibits Hepatitis C Viral Replication via Cyclooxygenase-2 Suppression and Reduces Virus-Induced Inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23583086&form=6&db=m Human follicular dendritic cells promote germinal center B cell survival by providing prostaglandins. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675544&form=6&db=m Post-exposure therapeutic efficacy of COX-2 inhibition against Burkholderia pseudomallei. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743193&form=6&db=m Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23850620&form=6&db=m Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23954207&form=6&db=m Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24003391&form=6&db=m Suppression of Heme Oxygenase-1 by Prostaglandin E2-Protein Kinase A-A-Kinase Anchoring Protein Signaling Is Central for Augmented Cyclooxygenase-2 Expression in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24037197&form=6&db=m Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24064666&form=6&db=m Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073313&form=6&db=m The Effect of Helicobacter pylori on Epidermal Growth Factor Receptor-Induced Signal Transduction and the Preventive Effect of Celecoxib in Gastric Cancer Cells. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24147040&form=6&db=m Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24211871&form=6&db=m Muramyl dipeptide potentiates staphylococcal lipoteichoic acid induction of cyclooxygenase-2 expression in macrophages. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24236890&form=6&db=m MicroRNA-29b modulates Japanese encephalitis virus-induced microglia activation by targeting tumor necrosis factor alpha-induced protein 3. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24259966&form=6&db=m Role of cyclooxygenase-2 in gastric cancer development and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24352469&form=6&db=m Highly pathogenic porcine reproductive and respiratory syndrome virus induces prostaglandin E2 production through cyclooxygenase 1, which is dependent on the ERK1/2-p-C/EBP-? pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24374907&form=6&db=m Comprehensive analysis of HPV expression in laryngeal squamous cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24496160&form=6&db=m Overexpression of cyclooxygenase-2 and transforming growth factor-beta 1 is an independent predictor of poor virological response to interferon therapy in chronic HCV genotype 4 patients. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24710938&form=6&db=m Cyclooxygenase-2 blockade inhibits accumulation and function of myeloid-derived suppressor cells and restores T cell response after traumatic stress. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24757289&form=6&db=m Peptidases from latex of Carica candamarcensis upregulate COX-2 and IL-1 mRNA transcripts against Salmonella enterica ser. Typhimurium-mediated inflammation. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24833939&form=6&db=m COX-2 Gene Promoter Methylation in Patients Infected with Helicobacter Pylori. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24907510&form=6&db=m Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-?B pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25045211&form=6&db=m Aspirin modulates innate inflammatory response and inhibits the entry of Trypanosoma cruzi in mouse peritoneal macrophages. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25092706&form=6&db=m Inhibition of cyclooxygenase-1 and cyclooxygenase-2 impairs Trypanosoma cruzi entry into cardiac cells and promotes differential modulation of the inflammatory response. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25278683&form=6&db=m Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25505069&form=6&db=m Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently Infected Endothelial Cells through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1. ongoing research,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526785&form=6&db=m Prostaglandin E 2 /Leukotriene B 4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25545478&form=6&db=m Intracellular colon cancer-associated Escherichia coli promote protumoral activities of human macrophages by inducing sustained COX-2 expression. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25670667&form=6&db=m Immunohistochemical Labelling of Cyclooxygenase-2 in Lung Lesions of Calves Infected with Mycoplasma bovis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25752858&form=6&db=m Expression of cyclooxygenase-2 in the mammary gland tissue of goats affected with caprine contagious agalactia. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916550&form=6&db=m Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26190062&form=6&db=m Recombinant OmpA protein fragments mediate interleukin-17 regulation to prevent Escherichia coli meningitis. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26231035&form=6&db=m HCV NS5A Up-Regulates COX-2 Expression via IL-8-Mediated Activation of the ERK/JNK MAPK Pathway. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26305786&form=6&db=m Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26386196&form=6&db=m Analysis of proinflammatory gene expression by RBIV infection in rock bream, Oplegnathus faciatus. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26408666&form=6&db=m CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26430761&form=6&db=m Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26449252&form=6&db=m Helicobacter pylori, cyclooxygenase-2 and evolution of gastric lesions: results from an intervention trial in China. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26485277&form=6&db=m Correction: Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26781425&form=6&db=m COX-1 and COX-2 polymorphisms in susceptibility to cerebral palsy in very preterm infants. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26843331&form=6&db=m Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26847631&form=6&db=m Besnoitia besnoiti infections activate primary bovine endothelial cells and promote PMN adhesion and NET formation under physiological flow condition. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870269&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and interleukin-32 in primary gastric B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931456&form=6&db=m Microglial activation induces neuronal death in Chandipura virus infection. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26952097&form=6&db=m BVDV alters uterine prostaglandin production during pregnancy recognition in cows. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27057306&form=6&db=m Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27097228&form=6&db=m Diminished COX-2/PGE2-Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27098007&form=6&db=m Design, synthesis and preliminary evaluation of the anti-inflammatory of the specific selective targeting druggable enzymome cyclooxygenase-2 (COX-2) small molecule. therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27137641&form=6&db=m Antibacterial and COX-1 Inhibitory Effect of Medicinal Plants from the Pamir Mountains, Afghanistan. diagnostic usage,therapeutic application,unassigned 1,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27198692&form=6&db=m Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27265729&form=6&db=m Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27342370&form=6&db=m Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma: Relationship with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27345318&form=6&db=m Local immune system in oviduct physiology and pathophysiology: attack or tolerance? causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27466058&form=6&db=m The inflammatory effect of infection with Hymenolepis diminuta via the increased expression and activity of COX-1 and COX-2 in the rat jejunum and colon. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27482714&form=6&db=m The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27631977&form=6&db=m Cytosolic and Calcium-Independent Phospholipases A2 Activation and Prostaglandins E2 Are Associated with Escherichia coli-Induced Reduction of Insulin Secretion in INS-1E Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27765359&form=6&db=m Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin E2 pathway induced during Trypanosoma cruzi infection. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27792775&form=6&db=m Immune Modulation as an Effective Adjunct Post-exposure Therapeutic for B. pseudomallei. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27881647&form=6&db=m Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28018318&form=6&db=m COX-2 Inhibition Reduces Brucella Bacterial Burden in Draining Lymph Nodes. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056333&form=6&db=m [Recommendation for the prevention and treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal ulcers and its complications]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28169407&form=6&db=m Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28317866&form=6&db=m Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400599&form=6&db=m LPS promotes a monocyte phenotype permissive for human cytomegalovirus immediate-early gene expression upon infection but not reactivation from latency. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28492740&form=6&db=m Selective COX-2 Inhibitor (Meloxicam) and Tooth-Supporting Bone Quality. A Histomorphometric Study in Rats. therapeutic application,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28602741&form=6&db=m Disease resistance and response against Vibrio anguillarum intestinal infection in European seabass (Dicentrarchus labrax) fed low fish meal and fish oil diets. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28779377&form=6&db=m Combination of EPA with Carotenoids and Polyphenol Synergistically Attenuated the Transformation of Microglia to M1 Phenotype Via Inhibition of NF-?B. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28813715&form=6&db=m Induction of Cyclooxygenase 2 by Streptococcus pyogenes Is Mediated by Cytolysins. ongoing research,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912780&form=6&db=m Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29120300&form=6&db=m Enterovirus 71 antagonizes the antiviral activity of host STAT3 and IL-6R with partial dependence on virus-induced miR-124. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29176767&form=6&db=m H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29373690&form=6&db=m Novel Function of Cyclooxygenase-2: Suppressing Mycobacteria by Promoting Autophagy via the Protein Kinase B/Mammalian Target of Rapamycin Pathway. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29728998&form=6&db=m KH-type splicing regulatory protein is regulated by nuclear factor-?B signaling to mediate innate immunity in Caco-2 cells infected by Salmonella enteritidis. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786110&form=6&db=m Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review). causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786374&form=6&db=m [EXPERIMENTAL STUDY ON LENTIVIRUS-MEDIATED MULTI-GENES CO-TRANSFECTION IN BONE MARROW MESENCHYMAL STEM CELLS FOR TREATMENT OF KNEE OSTEOARTHRITIS IN CYNOMOLGUS MONKEY]. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805552&form=6&db=m MicroRNA-381 protects myocardial cell function in children and mice with viral myocarditis via targeting cyclooxygenase-2 expression. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29859316&form=6&db=m Expression of immune-related genes of Nile tilapia Oreochromis niloticus after Gyrodactylus cichlidarum and Cichlidogyrus sclerosus infections demonstrating immunosupression in coinfection. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30139224&form=6&db=m The Association of PNPLA3, COX-2 and DHCR7 Polymorphisms with Advanced Liver Fibrosis in Patients with HCV Mono- Infection and HCV/HIV Co-Infection causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30148860&form=6&db=m The ameliorative effect of hemp seed hexane extracts on the Propionibacterium acnes-induced inflammation and lipogenesis in sebocytes. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30245627&form=6&db=m Raging the War Against Inflammation With Natural Products. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30250466&form=6&db=m Treating Influenza Infection, From Now and Into the Future. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30323556&form=6&db=m Designing of CD8+ and CD8+-overlapped CD4+ epitope vaccine by targeting late and early proteins of human papillomavirus. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30366771&form=6&db=m Risk factors for upper gastrointestinal bleeding among aspirin users: An old issue with new findings from a population-based cohort study. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30420854&form=6&db=m Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30529453&form=6&db=m Temporal profile of serum mitochondrial DNA (mtDNA) in patients with aneurysmal subarachnoid hemorrhage (aSAH). therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30687644&form=6&db=m Entamoeba histolytica Cyclooxygenase-Like Protein Regulates Cysteine Protease Expression and Virulence. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30736955&form=6&db=m IDO, COX and iNOS have an important role in the proliferation of Neospora caninum in neuron/glia co-cultures. therapeutic application,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30809216&form=6&db=m Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30915039&form=6&db=m Arachidonic Acid Derived Lipid Mediators Influence Kaposi's Sarcoma-Associated Herpesvirus Infection and Pathogenesis. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30970528&form=6&db=m Inhibitory effect of polysaccharide of Sargassum weizhouense on PCV2 induced inflammation in mice by suppressing histone acetylation. diagnostic usage,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30971474&form=6&db=m Replication of Marek's Disease Virus Is Dependent on Synthesis of De Novo Fatty Acid and Prostaglandin E2. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31075526&form=6&db=m - diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31203442&form=6&db=m Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31396568&form=6&db=m Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31611882&form=6&db=m Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31664161&form=6&db=m Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666208&form=6&db=m Eicosanoid pathway on host resistance and inflammation during Mycobacterium tuberculosis infection is comprised by LTB4 reduction but not PGE2 increment. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31732699&form=6&db=m EP2/4 Receptors Promote the Synthesis of PGE2 Increasing Tissue Damage in Bovine Endometrial Explants Induced by Escherichia coli. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31845079&form=6&db=m Effects of dietary arachidonic acid in European sea bass (Dicentrarchus labrax) distal intestine lipid classes and gut health. ongoing research,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31969876&form=6&db=m Transcriptome Profiling of Bovine Macrophages Infected by Mycobacterium avium spp. paratuberculosis Depicts Foam Cell and Innate Immune Tolerance Phenotypes. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32023904&form=6&db=m Upregulation of Cytokines and Differentiation of Th17 and Treg by Dendritic Cells: Central Role of Prostaglandin E2 Induced by Mycobacterium bovis. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32042330&form=6&db=m Sex Differences Revealed in a Mouse CFA Inflammation Model with Macrophage Targeted Nanotheranostics. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32102879&form=6&db=m Concurrent Control of KSHV Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: A New Prospect to the Therapeutic Potential of Lipoxin A4. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32154274&form=6&db=m Upregulation of PD-L1 Expression by Prostaglandin E2 and the Enhancement of IFN-? by Anti-PD-L1 Antibody Combined With a COX-2 Inhibitor in Mycoplasma bovis Infection. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32172202&form=6&db=m Club cell 10-kDa protein (CC10) inhibits cPLA2/COX2 pathway to alleviate RSV-induced airway inflammation and AHR. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32199598&form=6&db=m Cyclooxigenase-2 and osteopontin in gastric pre-neoplastic lesions in relation to H-pylori infection and grade of inflammation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32223750&form=6&db=m Melatonin antagonizes lipopolysaccharide-induced pulpal fibroblast responses. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32224280&form=6&db=m ROS induced by spring viraemia of carp virus activate the inflammatory response via the MAPK/AP-1 and PI3K signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328138&form=6&db=m Interaction of Cyclooxygenase-2 with Helicobacter pylori Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in Helicobacter pylori-Related Gastric Diseases. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32362888&form=6&db=m Cyclooxygenase-2 Inhibition Reduces Autophagy of Macrophages Enhancing Extraintestinal Pathogenic Escherichia coli Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32370749&form=6&db=m Sinensetin suppresses influenza a virus-triggered inflammation through inhibition of NF-?B and MAPKs signalings. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32464310&form=6&db=m Anti-biofilm effect by the combined action of fluconazole and acetylsalicylic acid against species of Candida parapsilosis complex. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32566414&form=6&db=m Host transcriptome-guided drug repurposing for COVID-19 treatment: a meta-analysis based approach. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32581017&form=6&db=m Morphoproteomics and Etiopathogenic Features of Pulmonary COVID-19 with Therapeutic Implications: A Case Study. ongoing research,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32632914&form=6&db=m Radiosynthesis and evaluation of [18F]FMTP, a COX-2 PET ligand. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32793561&form=6&db=m Biogenically Synthesized Polysaccharides-Capped Silver Nanoparticles: Immunomodulatory and Antibacterial Potentialities Against Resistant Pseudomonas aeruginosa. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32837217&form=6&db=m Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury. causal interaction,unassigned 2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32876916&form=6&db=m Anti-inflammatory and anti-oxidative effect of Korean propolis on Helicobacter pylori-induced gastric damage in vitro. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942970&form=6&db=m Natural COX-2 inhibitors as promising anti-inflammatory agents: an update. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32999131&form=6&db=m Ethyl acetate fraction of flavonoids from Polygonum hydropiper L. modulates pseudorabies virus-induced inflammation in RAW264.7 cells via the NF-?B and MAPK pathways. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33155730&form=6&db=m Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors. causal interaction,unassigned 3,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193319&form=6&db=m High Expression of IL-36? in Influenza Patients Regulates Interferon Signaling Pathway and Causes Programmed Cell Death During Influenza Virus Infection. ongoing research,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33253325&form=6&db=m Gene expression profiling in human neutrophils after infection with Acinetobacter baumannii in vitro. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485874&form=6&db=m Resistance mesenteric arteries display hypercontractility in the resolution time of Strongyloides venezuelensis infection. causal interaction,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33496060&form=6&db=m Targeting cyclooxygenase enzyme for the adjuvant COVID-19 therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33498280&form=6&db=m Weighted Gene Co-Expression Network Analysis Identifies Key Modules and Hub Genes Associated with Mycobacterial Infection of Human Macrophages. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33612720&form=6&db=m Immunohistochemical evaluation of interleukin-23 and cyclooxygenase-2 in the muscles of mice infected with Trichinella spiralis. ongoing research,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33673302&form=6&db=m Streptococcus suis Induces Expression of Cyclooxygenase-2 in Porcine Lung Tissue. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907758&form=6&db=m Cyclooxygenase inhibitor use is associated with increased COVID-19 severity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33912039&form=6&db=m Triptolide Modulates the Expression of Inflammation-Associated lncRNA-PACER and lincRNA-p21 in Mycobacterium tuberculosis-Infected Monocyte-Derived Macrophages. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33995374&form=6&db=m NSP2 Is Important for Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus to Trigger High Fever-Related COX-2-PGE2 Pathway in Pigs. unassigned -
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34034779&form=6&db=m Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34135407&form=6&db=m Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants. ongoing research,unassigned 4,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34137455&form=6&db=m The non-steroidal anti-inflammatory drug carprofen negatively impacts new bone formation and antibiotic efficacy in a rat model of orthopaedic-device-related infection. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149863&form=6&db=m Molecular Targets and Mechanisms of Scutellariae radix-Coptidis rhizoma Drug Pair for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34195100&form=6&db=m Proteomics Investigation of the Time Course Responses of RAW264.7 Macrophages to Infections With the Wild-Type and Twin-Arginine Translocation Mutant Strains of Brucella melitensis. causal interaction,unassigned 1,0
1.14.99.1 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258250&form=6&db=m Protective Effects of Silibinin on Helicobacter pylori-induced Gastritis: NF-?B and STAT3 as Potential Targets. therapeutic application,unassigned 3,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10327496&form=6&db=m A new case of NSAID-induced infertility. therapeutic application,unassigned 3,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10969080&form=6&db=m Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14747187&form=6&db=m Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15940311&form=6&db=m [Reversible infertility from nonsteroidal anti-inflammatory drugs] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309818&form=6&db=m COX-2 overexpression in peritoneal lesions is correlated with nonmenstrual chronic pelvic pain. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16493584&form=6&db=m Non-steroidal anti-inflammatory drugs (NSAIDs) and ovulation: lessons from morphology. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17307169&form=6&db=m A prostaglandin D2 system in the human testis. therapeutic application,unassigned 1,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22640168&form=6&db=m Evidence for an adaptation in ROS scavenging systems in human testicular peritubular cells from infertility patients. causal interaction,unassigned 3,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28166974&form=6&db=m Endometrial mRNA expression of selected pro-inflammatory factors and mucins in repeat breeder cows with and without subclinical endometritis. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28734688&form=6&db=m PTGS2 down-regulation in cumulus cells of infertile women with endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29852926&form=6&db=m Fragile X-related protein 1 (FXR1) regulates cyclooxygenase-2 (COX-2) expression at the maternal?fetal interface. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30994890&form=6&db=m Endometriosis. therapeutic application,unassigned 2,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31853218&form=6&db=m Cyclooxygenase-2 in Endometriosis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33348841&form=6&db=m The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Infertility http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33632047&form=6&db=m An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects. ongoing research,unassigned 2,0
1.14.99.1 Infertility, Female http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14701858&form=6&db=m Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup. therapeutic application,unassigned 1,0
1.14.99.1 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6441471&form=6&db=m [The effects of prostaglandin synthetase inhibitor on male infertility] ongoing research,unassigned 4,0
1.14.99.1 Infertility, Male http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22747653&form=6&db=m Expression of cyclooxygenase-1 (COX-1) and COX-2 in human male gametes from normal patients, and those with varicocele and diabetes: a potential molecular marker for diagnosing male infertility disorders. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1553930&form=6&db=m Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. causal interaction,unassigned 1,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2701650&form=6&db=m Interleukin-1 in the pathogenesis of and protection from inflammatory bowel disease. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2891468&form=6&db=m Possible mode of action of 5-aminosalicylic acid. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9219792&form=6&db=m Expression of cyclooxygenase-2 mRNA in active inflammatory bowel disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9303324&form=6&db=m New aspects of mast cell biology. ongoing research,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679035&form=6&db=m Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10327390&form=6&db=m Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10468690&form=6&db=m Selective COX-2 inhibitors and human inflammatory bowel disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10741939&form=6&db=m Cyclo-oxygenase-2 inhibitors ameliorate the severity of experimental colitis in rats. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10898767&form=6&db=m Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953541&form=6&db=m Selective COX-2 inhibitors and gastrointestinal mucosal injury: pharmacological and therapeutic considerations. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11137876&form=6&db=m Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11247889&form=6&db=m Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11266376&form=6&db=m Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11522796&form=6&db=m The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11820457&form=6&db=m Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12008668&form=6&db=m Safety of selective cyclooxygenase-2 inhibitors in inflammatory bowel disease. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12208114&form=6&db=m Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12395901&form=6&db=m Hepatocyte growth factor expression in dextran sodium sulfate-induced colitis in rats. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12494894&form=6&db=m COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523201&form=6&db=m [COX-2 inhibitors to patients with inflammatory bowel disease] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12702972&form=6&db=m Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12774242&form=6&db=m Cyclo-oxygenase 2 inhibitors: emerging roles in the gut. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12802790&form=6&db=m Cyclooxygenase-2 inhibitors in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891585&form=6&db=m Selective cyclooxygenase-2 inhibitors and relapse of inflammatory bowel disease. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529405&form=6&db=m Clinical implications of COX-1 and/or COX-2 inhibition for the distal gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069531&form=6&db=m Comparative analysis of cell adhesion molecules, cell cycle regulatory proteins, mismatch repair genes, cyclooxygenase-2, and DPC4 in carcinomas arising in inflammatory bowel disease and sporadic colon cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15331912&form=6&db=m Aggravation of inflammatory bowel disease by cyclooxygenase-2 inhibitors in rats. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15366676&form=6&db=m [Gastrointestinal complications related to NSAIDs] causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15369633&form=6&db=m The specialty of colon and rectal surgery: its impact on patient care and role in academic medicine. therapeutic application,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475742&form=6&db=m The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659320&form=6&db=m The effects of selective cyclooxygenase-2 inhibitors, celecoxib and rofecoxib, on experimental colitis induced by acetic acid in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15770816&form=6&db=m [Inflammatory bowel diseases] therapeutic application,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16038840&form=6&db=m Toxic effects of nonsteroidal antiinflammatory drugs on the small bowel, colon, and rectum. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273614&form=6&db=m Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease. causal interaction,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16454836&form=6&db=m The gastrointestinal safety and effect on disease activity of etoricoxib, a selective cox-2 inhibitor in inflammatory bowel diseases. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16469680&form=6&db=m Prevalence and Mechanism of Nonsteroidal Anti-Inflammatory Drug-Induced Clinical Relapse in Patients With Inflammatory Bowel Disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16570341&form=6&db=m Exacerbation of inflammatory bowel disease by nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors: fact or fiction? therapeutic application,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835710&form=6&db=m Mechanism underlying the reversal of contractility dysfunction in experimental colitis by cyclooxygenase-2 inhibition. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214885&form=6&db=m A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640979&form=6&db=m HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653443&form=6&db=m Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159171&form=6&db=m [COX-2 inhibitors in inflammatory bowel disease: friends or foes?] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18261323&form=6&db=m [Protective effect of epigallocatechin-3-gallate on inflammatory bowel disease: experiment with rat models of induced colitis] causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815359&form=6&db=m A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18819034&form=6&db=m Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19114773&form=6&db=m NSAIDs and the colon. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268443&form=6&db=m Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19636412&form=6&db=m CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19711064&form=6&db=m Exacerbation of inflammatory bowel diseases associated with the use of nonsteroidal anti-inflammatory drugs: myth or reality? ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808045&form=6&db=m Emerging role of cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions. causal interaction,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19946329&form=6&db=m The role of COX-2 in intestinal inflammation and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20299600&form=6&db=m Novel Anti-inflammatory Functions For Endothelial and Myeloid Cyclooxygenase-2 in a New Mouse Model of Crohn's Disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20649574&form=6&db=m Flavonoids exert distinct modulatory actions on cyclooxygenase 2 and NF-kappaB in an intestinal epithelial cell line (IEC18). causal interaction,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20803508&form=6&db=m Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study. therapeutic application,unassigned 1,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20857519&form=6&db=m A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. causal interaction,unassigned 3,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24462351&form=6&db=m Colon-targeted celecoxib ameliorates TNBS-induced rat colitis: A potential pharmacologic mechanism and therapeutic advantages. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24692797&form=6&db=m Role of selective cyclooxygenase-2 inhibitors in exacerbation of inflammatory bowel disease: A systematic review and meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25340915&form=6&db=m Tolerability of selective cyclooxygenase 2 inhibitors used for the treatment of rheumatological manifestations of inflammatory bowel disease. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25393372&form=6&db=m Cyclooxygenase-2 silencing for the treatment of colitis: a combined in vivo strategy based on RNA interference and engineered Escherichia coli. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25684939&form=6&db=m Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia. ongoing research,unassigned 1,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27450484&form=6&db=m Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis. causal interaction,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27539609&form=6&db=m Isoliquiritigenin suppresses tumor necrosis factor-?-induced inflammation via peroxisome proliferator-activated receptor-? in intestinal epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29630407&form=6&db=m The endogenous bioactive lipid prostaglandin D2-glycerol ester reduces murine colitis via DP1 and PPAR? receptors. causal interaction,unassigned 4,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29756563&form=6&db=m Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29764431&form=6&db=m Cyclooxygenase-2 immunoexpression in intestinal epithelium and lamina propria of cats with inflammatory bowel disease and low grade alimentary lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186819&form=6&db=m ?-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32525764&form=6&db=m Elucidation of colon-protective efficacy of diosgenin in experimental TNBS-induced colitis: inhibition of NF-?B/IkB-? and Bax/Caspase-1 signaling pathways. unassigned -
1.14.99.1 Inflammatory Bowel Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33397021&form=6&db=m [Clinical and genetic characteristics of patients with chronic enteropathy associated with SLCO2A1 gene]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585631&form=6&db=m Increased angiogenesis and lymphangiogenesis in inflammatory versus noninflammatory breast cancer by real-time reverse transcriptase-PCR gene expression quantification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20462604&form=6&db=m Role of COX-2 in Tumorospheres Derived from a Breast Cancer Cell Line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Inflammatory Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21903394&form=6&db=m Efficient synthesis of apricoxib, CS-706, a selective cyclooxygenase-2 inhibitor, and evaluation of inhibition of prostaglandin E2 production in inflammatory breast cancer cells. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21761591&form=6&db=m Antiviral activity of a selective COX-2 inhibitor NS-398 on avian influenza H5N1 infection. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Influenza in Birds http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25232731&form=6&db=m Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16272346&form=6&db=m Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835706&form=6&db=m Influenza ("Bird Flu"), inflammation and anti-inflammatory/analgesic drugs. causal interaction,unassigned 4,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18414668&form=6&db=m Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20657653&form=6&db=m Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21354125&form=6&db=m High-throughput screen of protein expression levels induced by cyclooxygenase-2 during influenza a virus infection. unassigned -
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21810053&form=6&db=m Immunomodulatory therapy for severe influenza. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22343630&form=6&db=m Influenza A virus induces Interleukin-27 through cyclooxygenase-2 and protein kinase A signaling. therapeutic application,unassigned 1,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25547723&form=6&db=m Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. causal interaction,unassigned 1,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26189369&form=6&db=m The cytokine storm of severe influenza and development of immunomodulatory therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27265729&form=6&db=m Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33147537&form=6&db=m Dissection of the potential anti-influenza materials and mechanism of Lonicerae japonicae flos based on in vivo substances profiling and network pharmacology. diagnostic usage,unassigned 3,0
1.14.99.1 Influenza, Human http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33193319&form=6&db=m High Expression of IL-36? in Influenza Patients Regulates Interferon Signaling Pathway and Causes Programmed Cell Death During Influenza Virus Infection. ongoing research,unassigned 4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11383931&form=6&db=m Inhibition of cyclooxygenase-1 or -2 on insulin sensitivity in healthy subjects. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12920574&form=6&db=m Association of a promoter variant in the inducible cyclooxygenase-2 gene (PTGS2) with type 2 diabetes mellitus in Pima Indians. causal interaction,unassigned 3,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14757778&form=6&db=m Androgens are necessary for the development of fructose-induced hypertension. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15153645&form=6&db=m A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis. therapeutic application,unassigned 1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15633605&form=6&db=m Pharmaceutical reversal of insulin resistance. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15726903&form=6&db=m Effects of diabetes and insulin resistance in pregnant rats on ex vivo vascular reaction to magnesium. causal interaction,unassigned 4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16447059&form=6&db=m Cyclooxygenase-2 (PTGS2) inhibitors augment the rate of hexose transport in L6 myotubes in an insulin- and AMPKalpha-independent manner. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778569&form=6&db=m Critical illness myopathy: what is happening? causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18370650&form=6&db=m A proposed new paradigm for insulin resistance. therapeutic application,unassigned 1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18370716&form=6&db=m Effect of celecoxib, a cyclooxygenase-2-specific inhibitor, on insulin sensitivity, C-reactive protein, homocysteine, and metabolic profile in overweight or obese subjects. unassigned -
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021698&form=6&db=m Selective COX2 inhibition improves whole body and muscular insulin resistance in fructose-fed rats. ongoing research,unassigned 2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19247274&form=6&db=m COX-2-mediated Inflammation in Fat Is Crucial for Obesity-linked Insulin Resistance and Fatty Liver. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19575453&form=6&db=m Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes. causal interaction,unassigned 3,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630964&form=6&db=m Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19755671&form=6&db=m Different Impacts of Saturated and Unsaturated Free Fatty Acids on COX-2 Expression in C2C12 Myotubes. unassigned -
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19764341&form=6&db=m Importance of cyclooxygenase 2-mediated low-grade inflammation in the development of fructose-induced insulin resistance in rats. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20022932&form=6&db=m Cyclooxygenase 2 inhibition exacerbates palmitate-induced inflammation and insulin resistance in skeletal muscle cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20101247&form=6&db=m Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. ongoing research,unassigned 1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20515643&form=6&db=m Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20665425&form=6&db=m Indomethacin activates peroxisome proliferator-activated receptor ? to improve insulin resistance in cotton pellet granuloma model. therapeutic application,unassigned 1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21640730&form=6&db=m The importance of cyclooxygenase 2-mediated oxidative stress in obesity-induced muscular insulin resistance in high-fat-fed rats. ongoing research,unassigned 4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001128&form=6&db=m Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23463959&form=6&db=m Serum adipocyte fatty acid-binding protein in the critically ill. unassigned -
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24742673&form=6&db=m Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24903239&form=6&db=m Influence of annexin A7 on insulin sensitivity of cellular glucose uptake. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422106&form=6&db=m Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity and insulin resistance. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25963660&form=6&db=m Regulation of MicroRNA 183 by Cyclooxygenase 2 in Liver Is DEAD-Box Helicase p68 (DDX5) Dependent: Role in Insulin Signaling. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26100521&form=6&db=m Omega-3-Acid Ethyl Esters Block the Protumorigenic Effects of Obesity in Mouse Models of Postmenopausal Basal-like and Claudin-Low Breast Cancer. causal interaction,unassigned 1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26604178&form=6&db=m Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522-1531. ongoing research,unassigned 2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26604179&form=6&db=m Response to Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522-1531. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26899878&form=6&db=m Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance. ongoing research,unassigned 2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26932930&form=6&db=m Importance of adipocyte cyclooxygenase-2 and prostaglandin E2-prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27186103&form=6&db=m Effects of insulin resistance and testosterone on the participation of cyclooxygenase isoforms in vascular reactivity. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27431935&form=6&db=m Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor ?. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27943105&form=6&db=m Hypolipidemic and hypoglycemic activities of a oleanolic acid derivative from Malva parviflora on streptozotocin-induced diabetic mice. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29109760&form=6&db=m Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29771124&form=6&db=m Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A2 Pathway. unassigned -
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30178825&form=6&db=m Correlations of glucose metabolism, insulin resistance and inflammatory factors with symptom score of patients with benign prostatic hyperplasia. ongoing research,unassigned 2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31061619&form=6&db=m Flavonoids from Camellia sinensis (L.) O. Kuntze seed ameliorates TNF-? induced insulin resistance in HepG2 cells. therapeutic application,unassigned 2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31247902&form=6&db=m The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31811565&form=6&db=m Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485218&form=6&db=m Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802136&form=6&db=m Network Pharmacology-Based Strategy to Investigate the Pharmacological Mechanisms of Ginkgo biloba Extract for Aging. causal interaction,unassigned 3,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33065146&form=6&db=m Low-dose lixisenatide protects against early-onset nephropathy induced in diabetic rats. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33274236&form=6&db=m A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease. causal interaction,unassigned 3,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34069822&form=6&db=m Ablation of TRPV1 Abolishes Salicylate-Induced Sympathetic Activity Suppression and Exacerbates Salicylate-Induced Renal Dysfunction in Diet-Induced Obesity. unassigned -
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145611&form=6&db=m Potential associations between variants of genes encoding regulators of inflammation, and mediators of inflammation in type 2 diabetes and insulin resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34175318&form=6&db=m Uterine anomalies in cell proliferation, energy homeostasis and oxidative stress in PCOS hamsters, M. auratus: Therapeutic potentials of melatonin. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12636104&form=6&db=m An immunohistochemical study of cyclooxygenase (COX)-2 expression in endocrine tumors of the pancreas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098866&form=6&db=m Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Insulinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21885043&form=6&db=m The gene encoding cyclooxygenase-2 is regulated by IL-1? and prostaglandins in 832/13 rat insulinoma cells. ongoing research,unassigned 1,0
1.14.99.1 Intermittent Claudication http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19706240&form=6&db=m Selective cyclooxygenase-2 inhibition reduces endothelial dysfunction and improves inflammatory status in patients with intermittent claudication. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Intermittent Claudication http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24775226&form=6&db=m Selective cyclooxygenase-2 inhibition reduces endothelial dysfunction and improves inflammatory status in patients with intermittent claudication. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11918320&form=6&db=m Epidural injection of cyclooxygenase-2 inhibitor attenuates pain-related behavior following application of nucleus pulposus to the nerve root in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12435978&form=6&db=m The role of cyclooxygenase-2 in lumbar disc herniation. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501196&form=6&db=m Spinal neural cyclooxygenase-2 mediates pain caused in a rat model of lumbar disk herniation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16157010&form=6&db=m Analysis and prevalence of inflammatory cells in subtypes of lumbar disc herniations under cyclooxygenase-2 inhibitor therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17631744&form=6&db=m YKL-40 in human lumbar herniated disc and its relationships with nitric oxide and cyclooxygenase-2. ongoing research,unassigned 3,0
1.14.99.1 Intervertebral Disc Displacement http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18383135&form=6&db=m Role of the tumor necrosis factor-alpha, cyclooxygenase-2, prostaglandin E2, and effect of low-intensity pulsed ultrasound in an in vitro herniated disc resorption model. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Intestinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12787734&form=6&db=m Prevalence and molecular diversity of pHS-2 plasmids, marker for arthritogenicity, among clinical Escherichia coli Shigella isolates. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151799&form=6&db=m Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668484&form=6&db=m The role of COX-2 in intestinal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12534075&form=6&db=m [A new drug approach approved in the USA. Cox-2 inhibitor in intestinal cancer] therapeutic application,unassigned 4,0
1.14.99.1 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150127&form=6&db=m Combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor (celecoxib) elicits antitumor immunity and long-term survival in CEA.Tg/MIN mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15992053&form=6&db=m The role of COX-2 in intestinal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909047&form=6&db=m Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Intestinal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18435741&form=6&db=m Prostaglandin E2 and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells. diagnostic usage,unassigned 3,0
1.14.99.1 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8945508&form=6&db=m Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288002&form=6&db=m In search of a better aspirin: suppression of intestinal polyposis by targeted inhibition of cyclooxygenase 2. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9439674&form=6&db=m Suppression of intestinal polyposis by inhibition of COX-2 in Apc knockout mice. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245490&form=6&db=m Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533709&form=6&db=m Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11580300&form=6&db=m Clinical potential of cyclo-oxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781300&form=6&db=m Chemoprevention of intestinal polyposis by COX-2 inhibition: from mouse to man. therapeutic application,unassigned 1,0
1.14.99.1 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941808&form=6&db=m Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Intestinal Polyposis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26650508&form=6&db=m Endogenous conversion of ?-6 to ?-3 polyunsaturated fatty acids in fat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/?-catenin signaling or activating 15-PGDH/IL-18. causal interaction,unassigned 3,0
1.14.99.1 Intestinal Pseudo-Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26780018&form=6&db=m Efficacy and safety of low-dose celecoxib in reducing post-operative paralytic ileus after major abdominal surgery. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426319&form=6&db=m PGE(2) -EP(2) receptor signaling in endothelium is activated by hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-?B. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22588264&form=6&db=m Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results. unassigned -
1.14.99.1 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25967073&form=6&db=m Potential role of aspirin in the prevention of aneurysmal subarachnoid hemorrhage. causal interaction,unassigned 3,0
1.14.99.1 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27296993&form=6&db=m Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32646326&form=6&db=m Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging. unassigned -
1.14.99.1 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33226922&form=6&db=m Response by Rodemerk et al to Letter Regarding Article, "Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging". unassigned -
1.14.99.1 Intracranial Aneurysm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33226924&form=6&db=m Letter by Wen et al Regarding Article, "Pathophysiology of Intracranial Aneurysms: COX-2 Expression, Iron Deposition in Aneurysm Wall, and Correlation With Magnetic Resonance Imaging". unassigned -
1.14.99.1 Intracranial Hemorrhages http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21838667&form=6&db=m 12-Lipoxygenase: A Potential Target for Novel Anti-Platelet Therapeutics. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Intracranial Hemorrhages http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26463949&form=6&db=m Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Intussusception http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15338171&form=6&db=m Role of nitric oxide and cyclooxygenase pathway in lipopolysaccharide-induced intussusception. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Intussusception http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15937849&form=6&db=m Role of nitric oxide and cyclooxygenase pathway in lipopolysaccharide-induced intussusception. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Intussusception http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437654&form=6&db=m Association of tumor necrosis factor, interleukin-6 and cyclooxygenase pathway with lipopolysaccharide-induced intussusception. unassigned -
1.14.99.1 Iritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12964963&form=6&db=m COX-2 inhibitors prolong trauma-induced elevations of iris hyaluronan. therapeutic application,unassigned 4,0
1.14.99.1 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11352890&form=6&db=m Increased release of arachidonic acid and eicosanoids in iron-overloaded cardiomyocytes. unassigned -
1.14.99.1 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23791636&form=6&db=m Specific roles for Group V secretory PLA? in retinal iron-induced oxidative stress. Implications for age-related macular degeneration. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Iron Overload http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34441564&form=6&db=m Iron Overload Protects from Obesity by Ferroptosis. causal interaction,unassigned 3,0
1.14.99.1 Irritable Bowel Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30186819&form=6&db=m ?-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3001248&form=6&db=m Development of cyclooxygenase and lipoxygenase metabolites of arachidonic acid after transient cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821016&form=6&db=m The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18323734&form=6&db=m Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. causal interaction,unassigned 3,0
1.14.99.1 Ischemic Attack, Transient http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33889074&form=6&db=m Inhibition of Acyl-CoA Synthetase Long-Chain Family Member 4 Facilitates Neurological Recovery After Stroke by Regulation Ferroptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3161220&form=6&db=m Enhanced in vivo platelet activation in subtypes of ischemic stroke. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8201150&form=6&db=m Pyrazolopyridine derivative acts as a novel cyclooxygenase inhibitor: antiplatelet effect in aged patients with ischemic stroke. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259748&form=6&db=m Platelet activation and lipid peroxidation in patients with acute ischemic stroke. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9616775&form=6&db=m Molecular pathology of cerebral ischemia: delayed gene expression and strategies for neuroprotection. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158633&form=6&db=m Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11340237&form=6&db=m Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in behavioral deficits induced by reversible spinal cord ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14592854&form=6&db=m Cyclooxygenase-2 expression and inhibition in atherothrombosis. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15041270&form=6&db=m Mutations within the cyclooxygenase-1 gene in aspirin non-responders with recurrence of stroke. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637312&form=6&db=m The Janus face of cyclooxygenase-2 in ischemic stroke: shifting toward downstream targets. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645019&form=6&db=m New drugs and new targets. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16102103&form=6&db=m Novel determinants of plaque instability. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16432513&form=6&db=m Prostaglandin E(2) EP1 receptors: downstream effectors of COX-2 neurotoxicity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16529823&form=6&db=m Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16728684&form=6&db=m Cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugs and the risk of ischemic stroke: a nested case-control study. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16879213&form=6&db=m Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17495879&form=6&db=m Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17702963&form=6&db=m An interactive association of common sequence variants in the neuropeptide Y gene with susceptibility to ischemic stroke. unassigned -
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17704356&form=6&db=m Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-{alpha} in the Rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19046748&form=6&db=m Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19485927&form=6&db=m Genetic and Molecular Determinants of Atherosclerotic Plaque Instability. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19631939&form=6&db=m Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19741338&form=6&db=m Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in humans. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20140892&form=6&db=m Validation of claims-based diagnostic and procedure codes for cardiovascular and gastrointestinal serious adverse events in a commercially-insured population. therapeutic application,unassigned 4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20472470&form=6&db=m Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 Polymorphisms on 90-Day Ischemic Stroke Functional Outcome: A Novel Finding. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20560882&form=6&db=m Intravenous implanted neural stem cells migrate to injury site, reduce infarct volume, and improve behavior after cerebral ischemia. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21236709&form=6&db=m Upregulated expression of Toll-like receptor 4 in peripheral blood of ischaemic stroke patients correlates with cyclooxygenase 2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21816595&form=6&db=m A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population. diagnostic usage,unassigned 1,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21843661&form=6&db=m Microglia and cyclooxygenase-2: Possible therapeutic targets of progesterone for stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22763923&form=6&db=m Association of COX-2 rs20417 with aspirin resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22960396&form=6&db=m Environmental nitrogen dioxide (NO(2)) exposure influences development and progression of ischemic stroke. causal interaction,unassigned 3,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23907768&form=6&db=m Cyclooxygenase-2 genetic polymorphism and stroke subtypes in chinese. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24561313&form=6&db=m Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24930730&form=6&db=m Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24990856&form=6&db=m Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25229174&form=6&db=m Reversible cerebral vasoconstriction syndrome possibly induced by etoricoxib. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748877&form=6&db=m Cardiovascular risks associated with non-aspirin non-steroidal anti-inflammatory drug use. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25957909&form=6&db=m COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27087648&form=6&db=m Trans-Cinnamaldehyde, An Essential Oil in Cinnamon Powder, Ameliorates Cerebral Ischemia-Induced Brain Injury via Inhibition of Neuroinflammation Through Attenuation of iNOS, COX-2 Expression and NF?-B Signaling Pathway. therapeutic application,unassigned 4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27363623&form=6&db=m Influence of the Cyclooxygenase-2 Gene -765G/C and -1195G/A Polymorphisms on Development of Ischemic Stroke. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28108096&form=6&db=m Variants in COX-2, PTGIS, and TBXAS1 Are Associated with Carotid Artery or Intracranial Arterial Stenosis and Neurologic Deterioration in Ischemic Stroke Patients. causal interaction,unassigned 2,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449186&form=6&db=m The risk of lower gastrointestinal bleeding in low-dose aspirin users. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28704403&form=6&db=m Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28948649&form=6&db=m Association of GPIa and COX-2 gene polymorphism with aspirin resistance. ongoing research,unassigned 2,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29977356&form=6&db=m Smoking and drinking influence the advancing of ischemic stroke disease by targeting PTGS2 and TNFAIP3. causal interaction,unassigned 2,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31125596&form=6&db=m Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves against ischemic stroke in rats. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31222746&form=6&db=m Silencing of PTGS2 exerts promoting effects on angiogenesis endothelial progenitor cells in mice with ischemic stroke via repression of the NF-?B signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31735164&form=6&db=m Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32777346&form=6&db=m Inhibition of cyclooxygenase-1 does not reduce mortality in post-ischemic stroke rats. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973660&form=6&db=m Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34413669&form=6&db=m Genetic Variation of Inflammatory Genes to Ischemic Stroke Risk in a Chinese Han Population. causal interaction,unassigned 3,0
1.14.99.1 Jaw Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17097611&form=6&db=m Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts. causal interaction,unassigned 3,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8668291&form=6&db=m [Levels of different metabolites of arachidonic acid in synovial fluid of patients with arthrosis or rheumatoid arthritis] causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8761181&form=6&db=m Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8898449&form=6&db=m Non-steroidal anti-inflammatory drug gastropathy: causes and treatment. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9433877&form=6&db=m Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9714356&form=6&db=m Detection of COX-1 and COX-2 isoforms in synovial fluid cells from inflammatory joint diseases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11079466&form=6&db=m Regulation of cyclooxygenase-2 expression in human osteoblastic cells by N-acetylcysteine. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11772254&form=6&db=m Therapeutic potential of COX-2 inhibitors in arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12082280&form=6&db=m COX-1, COX-2 and articular joint disease: a role for chondroprotective agents. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173278&form=6&db=m Arthropathy in art and the history of pain management--through the centuries to cyclooxygenase-2 inhibitors. therapeutic application,unassigned 3,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12410658&form=6&db=m Factor-sparing use of the COX-2 inhibitor rofecoxib in haemophilic arthropathy. therapeutic application,unassigned 3,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12518073&form=6&db=m [Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model] causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12752891&form=6&db=m Evaluation of cyclooxygenase 2 inhibitor use in patients admitted to a large teaching hospital. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16291600&form=6&db=m Evaluation of the efficacy and safety of etoricoxib in the treatment of hemophilic arthropathy. therapeutic application,unassigned 4,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415488&form=6&db=m The future of traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors in the treatment of inflammation and pain. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19624842&form=6&db=m An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26110105&form=6&db=m Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26538453&form=6&db=m Choosing and using non-steroidal anti-inflammatory drugs in haemophilia. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Joint Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34042011&form=6&db=m Pain management in people with hemophilia in childhood and young adulthood. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11357226&form=6&db=m Differential effects of hexoses and sucrose, and platelet-derived growth factor isoforms on cyclooxygenase-1 and -2 mRNA expression in keloid, hypertrophic scar and granulation tissue fibroblasts. ongoing research,unassigned 4,0
1.14.99.1 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244328&form=6&db=m Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)-beta1-induced collagen synthesis. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24061401&form=6&db=m Immunohistochemical Evaluation of COX-1 and COX-2 Expression in Keloid and Hypertrophic Scar. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27855376&form=6&db=m Growth Differentiation Factor-9 Promotes Fibroblast Proliferation and Migration in Keloids through the Smad2/3 Pathway. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30881820&form=6&db=m Immunohistochemical Expression of Cyclooxygenases in Hypertrophic Scars and Keloids. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34514006&form=6&db=m Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine. ongoing research,unassigned 2,0
1.14.99.1 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2453319&form=6&db=m Modulation of immunogenic keratitis in rabbits by topical administration of inhibitors of lipoxygenase and cyclooxygenase. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15017024&form=6&db=m Cyclooxygenase-2 expression in the cornea of dogs with keratitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051851&form=6&db=m Role of inflammatory cytokine-induced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19234234&form=6&db=m Pathophysiology of cyclooxygenase inhibition in animal models. causal interaction,unassigned 4,0
1.14.99.1 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19547717&form=6&db=m Lornoxicam suppresses recurrent herpetic stromal keratitis through down-regulation of nuclear factor-kappaB: an experimental study in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Keratitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553634&form=6&db=m Effects of COX-2 inhibitor NS-398 on IL-10 expression in rat fungal keratitis. ongoing research,unassigned 3,0
1.14.99.1 Keratoacanthoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417761&form=6&db=m Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Keratoacanthoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14976535&form=6&db=m Biological behavior of keratoacanthoma and squamous cell carcinoma: telomerase activity and COX-2 as potential markers. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Keratoacanthoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25575894&form=6&db=m Expression of Cyclooxygenase-2 in Squamous Cell Carcinoma and Keratoacanthoma and its Clinical Significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Keratoconus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8402271&form=6&db=m Modification of prostaglandin E2 and collagen synthesis in keratoconus fibroblasts, associated with an increase of interleukin 1 alpha receptor number. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Keratosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17497299&form=6&db=m Expression of p63 and cyclooxygenase-2 and their correlation in skin tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417761&form=6&db=m Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126310&form=6&db=m Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15327557&form=6&db=m Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458531&form=6&db=m Nonsteroidal anti-inflammatory drug use in the prevention and treatment of squamous cell carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16279229&form=6&db=m [Cyclooxygenases in the skin] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16700663&form=6&db=m Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17488409&form=6&db=m Genetically determined susceptibility to COX-2 inhibitors: a report of exaggerated responders to diclofenac 3% gel in the treatment of actinic keratoses. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17497299&form=6&db=m Expression of p63 and cyclooxygenase-2 and their correlation in skin tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17578436&form=6&db=m Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096163&form=6&db=m Field treatment of actinic keratoses - focus on COX-2-inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115882&form=6&db=m Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21601872&form=6&db=m Immunohistochemical Detection of COX-2 in Feline and Canine Actinic Keratoses and Cutaneous Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460857&form=6&db=m Epithelial to mesenchymal transition in cutaneous squamous cell carcinoma is correlated with COX-2 expression but not with the presence of stromal macrophages or CD10-expressing cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22627629&form=6&db=m The expression of p53 and COX-2 in basal cell carcinoma, squamous cell carcinoma and actinic keratosis cases. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22667343&form=6&db=m Immunohistochemical study of cyclooxygenase-2 in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23095338&form=6&db=m Significance of Cyclooxygenase 2, EZH-2 Polycomb Group and p53 Expression in Actinic Keratosis and Squamous Cell Carcinomas of the Skin. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24128166&form=6&db=m Clinical outcome and cyclo-oxygenase-2 expression in five dogs with solar dermatitis/actinic keratosis treated with firocoxib. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27046744&form=6&db=m LONG-TERM USE OF A NEW TOPICAL FORMULATION CONTAINING PIROXICAM 0.8% AND SUNSCREEN: EFFICACY AND TOLERABILITY ON ACTINIC KERATOSIS. A PROOF OF CONCEPT STUDY. causal interaction,unassigned 1,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28150108&form=6&db=m Cyclooxygenase in Cancer Prevention and Treatments for Actinic Keratosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30523664&form=6&db=m Treatment of actinic keratosis through inhibition of cyclooxygenase-2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Keratosis, Actinic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30618533&form=6&db=m Cyclooxygenase-2 expression in actinic keratosis. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Keratosis, Seborrheic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22540084&form=6&db=m Overexpression of linker for activated T cells, cyclooxygenase-2, CD1a, CD68 and myeloid/histiocyte antigen in an inflamed seborrheic keratosis. unassigned -
1.14.99.1 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1527701&form=6&db=m Autoimmune kidney disease in MRL/lpr mice inhibited by OK-432; II. Effect of indomethacin. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11510235&form=6&db=m [NSAID--COX-2-inhibitors, where is the difference? Focus on the modes of action] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17537981&form=6&db=m Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21733195&form=6&db=m Cause for concern in the use of non-steroidal anti-inflammatory medications in the community -a population-based study. therapeutic application,unassigned 1,0
1.14.99.1 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30265586&form=6&db=m Glucocorticoids use in kidney transplant setting. causal interaction,unassigned 1,0
1.14.99.1 Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34367469&form=6&db=m The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes. unassigned -
1.14.99.1 Kidney Diseases, Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12490538&form=6&db=m Alterations in renal cytosolic phospholipase A2 and cyclooxygenases in polycystic kidney disease. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Kidney Diseases, Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475460&form=6&db=m COX-2 expression in cystic kidneys is dependent on dietary n-3 fatty acid composition. unassigned -
1.14.99.1 Kidney Diseases, Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28826940&form=6&db=m Distinct oxylipin alterations in diverse models of cystic kidney diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Kidney Diseases, Cystic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671914&form=6&db=m Cyclooxygenase 2 inhibition slows disease progression and improves the altered renal lipid mediator profile in the Pkd2WS25/- mouse model of autosomal dominant polycystic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4024033&form=6&db=m The effect of platelet number and haematocrit on whole blood thromboxane synthesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10560684&form=6&db=m Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic. causal interaction,unassigned 3,0
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12224048&form=6&db=m Contribution of prostaglandin D2 synthase to progression of renal failure and dialysis dementia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12454227&form=6&db=m Cyclooxygenase inhibition improves endothelium-dependent vasodilatation in patients with chronic renal failure. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681341&form=6&db=m Pharmacokinetics of etoricoxib in patients with renal impairment. ongoing research,unassigned 1,0
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16235511&form=6&db=m Adverse interactions of rofecoxib with lisinopril in spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912740&form=6&db=m Effects of No.2 Renal Failure Recipe on expressions of cyclooxygenase-2 and -1 mRNAs in rats with chronic renal failure. ongoing research,unassigned 4,0
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20007347&form=6&db=m Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582905&form=6&db=m Analgesic use and the risk for progression of chronic kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21335517&form=6&db=m Cyclooxygenase 2 promotes parathyroid hyperplasia in ESRD. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26543101&form=6&db=m Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29982796&form=6&db=m Prostaglandin E2 receptor EP2 mediates the effect of cyclooxygenase 2 on secondary parathyroid hyperplasia in end-stage renal disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,1,1
1.14.99.1 Kidney Failure, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32310965&form=6&db=m Relative risk of end-stage renal disease requiring dialysis in treated ankylosing spondylitis patients compared with individuals without ankylosing spondylitis: A nationwide, population-based, matched-cohort study. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25487445&form=6&db=m Hypoxia promotes 786-O cells invasiveness and resistance to sorafenib via HIF-2?/COX-2. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28155120&form=6&db=m Novel glycoside from Wedelia calendulacea inhibits diethyl nitrosamine-induced renal cancer via downregulating the COX-2 and PEG ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782823&form=6&db=m Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. causal interaction,unassigned 2,0
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15111350&form=6&db=m Expression of Cox-2 protein in radioresistant laryngeal cancer. ongoing research,unassigned 4,0
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15510031&form=6&db=m Tissue microarray analysis reveals prognostic significance of COX-2 expression for local relapse in T1-2N0 larynx cancer treated with primary radiation therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,4
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15520079&form=6&db=m Expression of Cox-2 protein in radioresistant laryngeal cancer. unassigned -
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637814&form=6&db=m [Tissue microarray technique and its uses in study of relation between expression of cyclooxygenase in laryngeal neoplasms] diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16720448&form=6&db=m Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19554635&form=6&db=m Low COX2 in tumor and upregulation in stroma mark laryngeal squamous cell carcinoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20545118&form=6&db=m [Effects of rosiglitazone on the Hep-2 cell proliferation, cell cycle and COX-2 expression] ongoing research,unassigned 3,0
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22000259&form=6&db=m [Analysis of HIF-1? and COX-2 expression in tumor stroma and correlation with the degree of neoplasm invasiveness in laryngeal cancer--preliminary study]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22715028&form=6&db=m Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22855152&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in patients with advanced cancer of the larynx who have undergone induction chemotherapy with the intention of preserving phonation. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25736926&form=6&db=m Cannabis smoke can be a major risk factor for early-age laryngeal cancer-a molecular signaling-based approach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27382672&form=6&db=m [Expression of p53, p21, PCNA and COX-2 and its relationship with recurrence in the early-stage laryngeal cancer with negative surgical margin]. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Laryngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28739688&form=6&db=m Cyclooxygenase-2 Inhibition Enhances Proliferation of NKT Cells Derived from Patients with Laryngeal Cancer. ongoing research,unassigned 4,0
1.14.99.1 Laryngismus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21217919&form=6&db=m Aspirin-exacerbated respiratory disease: evaluation and management. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Laryngismus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663486&form=6&db=m Update on aspirin desensitization for chronic rhinosinusitis with polyps in aspirin-exacerbated respiratory disease (AERD). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Laryngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18251032&form=6&db=m A new model of laryngitis: neuropeptide, cyclooxygenase, and cytokine profile. unassigned -
1.14.99.1 Laryngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20349107&form=6&db=m The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Laryngopharyngeal Reflux http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12782823&form=6&db=m Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. causal interaction,unassigned 2,0
1.14.99.1 Latent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20169190&form=6&db=m Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Latent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27776487&form=6&db=m The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Leg Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745699&form=6&db=m Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1374254&form=6&db=m Indomethacin for the treatment of symptomatic leiomyoma uteri during pregnancy. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,3,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4064305&form=6&db=m The effect of a prostaglandin synthetase inhibitor, indomethacin, on excessive uterine bleeding. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12517588&form=6&db=m Uterine leiomyomas express myometrial contractile-associated proteins involved in pregnancy-related hormone signaling. causal interaction,unassigned 1,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17356170&form=6&db=m A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator. ongoing research,unassigned 3,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17550381&form=6&db=m Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468574&form=6&db=m Memy I: a novel murine model for uterine leiomyoma using adenovirus-enhanced human fibroid explants in severe combined immune deficiency mice. ongoing research,unassigned 3,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553222&form=6&db=m The endothelin axis in uterine leiomyomas: new insights. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23398724&form=6&db=m High expression of cyclooxygenase-2 in uterine fibroids and its correlation with cell proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24130091&form=6&db=m Comparative expression of thioredoxin-1 in uterine leiomyomas and myometrium. causal interaction,unassigned 2,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24398114&form=6&db=m Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours. causal interaction,unassigned 4,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25001017&form=6&db=m Cyclooxygenase-2 inhibitor, celecoxib, inhibits leiomyoma cell proliferation through the nuclear factor ?B pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27799459&form=6&db=m Berberine Inhibits Uterine Leiomyoma Cell Proliferation via Downregulation of Cyclooxygenase 2 and Pituitary Tumor-Transforming Gene 1. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Leiomyoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805520&form=6&db=m Analysis of the in vitro effects of di-(2-ethylhexyl) phthalate exposure on human uterine leiomyoma cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15700850&form=6&db=m Cyclooxygenase-2 expression in uterine leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483309&form=6&db=m The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17550381&form=6&db=m Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645019&form=6&db=m Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661295&form=6&db=m Cyclooxygenase 2 expression in soft tissue leiomyosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Leiomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21412163&form=6&db=m Cyclooxygenase-2 Is an Independent Predictor of Poor Prognosis in Uterine Leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6435888&form=6&db=m Arachidonic acid metabolism in murine leishmaniasis (Donovani): ex-vivo evidence for increased cyclooxygenase and 5-lipoxygenase activity in spleen cells. causal interaction,unassigned 2,0
1.14.99.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24850789&form=6&db=m Role of Prostaglandin F2? Production in Lipid Bodies From Leishmania infantum chagasi: Insights on Virulence. therapeutic application,unassigned 2,0
1.14.99.1 Leishmaniasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25526785&form=6&db=m Prostaglandin E 2 /Leukotriene B 4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection. causal interaction,unassigned 3,0
1.14.99.1 Lentigo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22506937&form=6&db=m siRNA-mediated knock-down of COX-2 in melanocytes suppresses melanogenesis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12752141&form=6&db=m Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16760523&form=6&db=m Cyclooxygenase 2 expression in vessels and nerves in reversal reaction leprosy. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17222216&form=6&db=m Expression of cyclooxygenase-2, alpha 1-acid-glycoprotein and inducible nitric oxide synthase in the developing lesions of murine leprosy. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Leprosy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33594711&form=6&db=m Cyclooxygenase 2 and vascular endothelial growth factor-potential targets to manage lepra reactions: A case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Leprosy, Lepromatous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813774&form=6&db=m TLR6-Driven Lipid Droplets in Mycobacterium leprae-Infected Schwann Cells: Immunoinflammatory Platforms Associated with Bacterial Persistence. unassigned -
1.14.99.1 Leprosy, Tuberculoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12752141&form=6&db=m Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22078&form=6&db=m Precursor role of arachidonic acid in release of slow reacting substance from rat basophilic leukemia cells. ongoing research,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1433181&form=6&db=m Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847426&form=6&db=m Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors. therapeutic application,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2982366&form=6&db=m Detection of a novel cyclooxygenase metabolite produced by human promyelocytic leukemia (HL-60) cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3086266&form=6&db=m Studies on lipoxygenase inhibitors. I. MY3-469 (3-methoxytropolone), a potent and selective inhibitor of 12-lipoxygenase, produced by Streptoverticillium hadanonense KY11449. therapeutic application,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3102559&form=6&db=m sn-1,2-Diacylglycerols and phorbol diesters stimulate thromboxane synthesis by de novo synthesis of prostaglandin H synthase in human promyelocytic leukemia cells. ongoing research,unassigned 3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3120517&form=6&db=m Metabolism of cyclooxygenase and lipoxygenase products by 15-prostaglandin dehydrogenase from human HL-60 leukemia cells. ongoing research,unassigned 4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3144111&form=6&db=m Butyric acid enhances cyclooxygenase activity in rat basophilic leukemia 2H3 cells. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6163214&form=6&db=m Interferon-resistant cell line lacks fatty acid cyclooxygenase activity. therapeutic application,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6405452&form=6&db=m Selective inhibition of the lipoxygenase metabolic pathway of arachidonic acid by the SRS-A antagonist, FPL 55712. ongoing research,unassigned 2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6438380&form=6&db=m Pharmacological properties of a new anti-inflammatory compound, alpha-(3,5-di-tert-butyl-4-hydroxybenzylidene)-gamma-butyrolacto ne (KME-4), and its inhibitory effects on prostaglandin synthetase and 5-lipoxygenase. causal interaction,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7378431&form=6&db=m Enzymatic formation of prostaglandin D2 by rat basophilic leukemia cells and normal rat mast cells. causal interaction,unassigned 3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7996452&form=6&db=m Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. ongoing research,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8140259&form=6&db=m The pharmacologic effects of 5-[3,5-bis(1,1-dimethylethyl)-4- hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione, choline salt (CI-986), a novel inhibitor of arachidonic acid metabolism in models of inflammation, analgesia and gastric irritation. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8295221&form=6&db=m Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8985016&form=6&db=m Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. ongoing research,unassigned 3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9865500&form=6&db=m Anti-inflammatory activity of myricetin-3-O-beta-D-glucuronide and related compounds. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10526183&form=6&db=m Cyclooxygenase-2 activity is necessary for the angiogenic properties of oncostatin M. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11417904&form=6&db=m Implantation: molecular basis of embryo-uterine dialogue. ongoing research,unassigned 3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11553371&form=6&db=m Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation. unassigned -
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745483&form=6&db=m Constitutive expression of the cyclooxygenase-2 gene in T-cell lines infected with human T cell leukemia virus type I. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060628&form=6&db=m Cyclooxygenase-2 expression is a novel prognostic factor in malignant mesothelioma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12221597&form=6&db=m Bioactive constituents of the seeds of Brucea javanica. ongoing research,unassigned 3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15190260&form=6&db=m Cyclooxygenase-1, but not -2, is upregulated in NB4 leukemic cells and human primary promyelocytic blasts during differentiation. ongoing research,unassigned 4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15354952&form=6&db=m [Apoptosis in P388 leukemia cells induced by specific inhibitors of 5- and 12-lipoxygenase and the product of cyclooxygenase, prostaglandin E2] causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15846116&form=6&db=m Induction of apoptosis and inhibition of cyclooxygenase-2 expression by N-methyl-N'-nitro-N-nitrosoguanidine in human leukemia cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550520&form=6&db=m Antitumor effects of celecoxib on K562 leukemia cells are mediated by cell-cycle arrest, caspase-3 activation, and downregulation of Cox-2 expression and are synergistic with hydroxyurea or imatinib. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17009257&form=6&db=m The role of fibroblasts and fibroblast-derived factors in periprosthetic osteolysis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17089125&form=6&db=m Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17121179&form=6&db=m Anti-inflammatory action of phenolic compounds from Gastrodia elata root. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17125190&form=6&db=m Adaptive configuring of radial basis function network by hybrid particle swarm algorithm for QSAR studies of organic compounds. therapeutic application,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17143540&form=6&db=m Inhibition of cyclooxygenase-2 and telomerase activities in human leukemia cells by dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp. ongoing research,unassigned 3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17277882&form=6&db=m Triptolide inhibits cyclooxygenase-2 and inducible nitric oxide synthase expression in human colon cancer and leukemia cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17450529&form=6&db=m Cyclooxygenase-1, but not -2, in blast cells of patients with acute leukemia. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17881051&form=6&db=m Cyclooxygenase-2 (Cox-2) and blast cells of patients with acute leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890724&form=6&db=m Mifepristone, but not levonorgestrel, inhibits human blastocyst attachment to an in vitro endometrial three-dimensional cell culture model. causal interaction,unassigned 2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956662&form=6&db=m [Expression of cyclooxygenase-2 in bone marrow cells of chronic leukemia and its significance.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17999062&form=6&db=m Dup-697, a specific COX-2 inhibitor, suppresses growth and induces apoptosis on K562 leukemia cells by cell-cycle arrest and caspase-8 activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,2
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18206148&form=6&db=m Effect of levonorgestrel and mifepristone on endometrial receptivity markers in a three-dimensional human endometrial cell culture model. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281656&form=6&db=m Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18339712&form=6&db=m Prokineticin 1 signaling and gene regulation in early human pregnancy. therapeutic application,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18354491&form=6&db=m Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18981574&form=6&db=m Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19126304&form=6&db=m Effect of natsudaidain isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in RBL-2H3 cells. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236744&form=6&db=m [Expression of cyclooxygenase-2 in bone marrow cells of leukemia patients and its association with angiogenesis.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19763374&form=6&db=m Marrow Stromal Cell-Based Cyclooxygenase 2 Ex Vivo Gene-Transfer Strategy Surprisingly Lacks Bone-Regeneration Effects and Suppresses the Bone-Regeneration Action of Bone Morphogenetic Protein 4 in a Mouse Critical-Sized Calvarial Defect Model. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825968&form=6&db=m Vascular endothelial growth factor-c (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20022444&form=6&db=m Endometrial and conceptus expression of HoxA10, transforming growth factor beta1, leukemia inhibitory factor, and prostaglandin H synthase-2 in early pregnant pigs with gonadotropin-induced estrus. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332435&form=6&db=m Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R. causal interaction,unassigned 4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20673699&form=6&db=m Inhibition of cyclooxygenase-2-dependent survivin mediates decursin-induced apoptosis in human KBM-5 myeloid leukemia cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20944149&form=6&db=m Association study of cyclooxygenase 2 single nucleotide polymorphisms and childhood acute lymphoblastic leukemia in Taiwan. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115633&form=6&db=m Critical evaluation of human endometrial explants as an ex vivo model system: a molecular approach. diagnostic usage,unassigned 3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21214483&form=6&db=m Evaluation of selected lichens from iceland for cancer chemopreventive and cytotoxic activity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21848701&form=6&db=m Functional Genetic Variations of Cyclooxygenase-2 and Susceptibility to Acute Myeloid Leukemia in a Chinese Population. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21862873&form=6&db=m Cox-2 inhibitors induce early c-Myc downregulation and lead to expression of differentiation markers in leukemia cells. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21895406&form=6&db=m Leukemic cells modulate induction of COX-2 in human stromal fibroblasts. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21964530&form=6&db=m Serum vascular endothelial growth factor and COX-2/5-LOX inhibition in advanced non-small cell lung cancer: Cancer and Leukemia Group B 150304. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22245431&form=6&db=m Anti-leukemic effects of gallic acid on human leukemia K562 cells: Downregulation of COX-2, inhibition of BCR/ABL kinase and NF-?B inactivation. ongoing research,unassigned 4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22330070&form=6&db=m AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22569419&form=6&db=m Immunostimulatory effect of laminarin on RAW 264.7 mouse macrophages. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22668024&form=6&db=m COX-2 expression in fibroblast aggregates as a functional indicator for the anti-inflammatory activity of leukemia patients' bone marrow-derived hematopoietic cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22715107&form=6&db=m Identification of novel target proteins in sebaceous gland carcinoma. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23114124&form=6&db=m [Effects of COX-2 inhibitor celecoxib on expressions of VEGF, b-FGF and TGF-? mRNA in acute leukemia cells]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23165704&form=6&db=m Human pericytes for ischemic heart repair. diagnostic usage,unassigned 2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357584&form=6&db=m Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptoticeffect. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426803&form=6&db=m Lipoxin A4 blocks embryo implantation by controlling estrogen receptor ? activity. causal interaction,unassigned 2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23452119&form=6&db=m Combination of Celecoxib and Doxorubicin Increases the Growth Inhibition and Apoptosis in Acute Myeloid Leukemia Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23645839&form=6&db=m AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/?-catenin signaling pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24705122&form=6&db=m The role of AMP-activated protein kinase in quercetin-induced apoptosis of HL-60 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24965577&form=6&db=m Autocrine prostaglandin E2 signaling promotes promonocytic leukemia cell survival via COX-2 expression and MAPK pathway. unassigned -
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25378661&form=6&db=m EPAC2-mediated calreticulin regulates LIF and COX2 expression in human endometrial glandular cells. causal interaction,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25850816&form=6&db=m Ex Vivo Induced Regulatory Human/Murine Mesenchymal Stem Cells as Immune Modulators. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26376734&form=6&db=m Licarin A is a candidate compound for the treatment of immediate hypersensitivity via inhibition of rat mast cell line RBL-2H3 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26929574&form=6&db=m Anti-inflammatory, Anti-estrogenic, and Anti-implantation Activity of Bergia suffruticosa (Delile) Fenzl. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27461609&form=6&db=m Antileukemic effects of piperlongumine and alpha lipoic acid combination on Jurkat, MEC1 and NB4 cells in vitro. ongoing research,unassigned 3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27563447&form=6&db=m A genetic database can be utilized to identify potential biomarkers for biphenotypic hepatocellular carcinoma-cholangiocarcinoma. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489511&form=6&db=m Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28795083&form=6&db=m Mechanical instability and titanium particles induce similar transcriptomic changes in a rat model for periprosthetic osteolysis and aseptic loosening. diagnostic usage,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28978315&form=6&db=m Resveratrol enhances anticancer effects of paclitaxel in HepG2 human liver cancer cells. causal interaction,unassigned 2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29345286&form=6&db=m Cyclooxygenase-2 expression is induced by celecoxib treatment in lung cancer cells and is transferred to neighbor cells via exosomes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29501042&form=6&db=m Clostridium difficile toxin B recombinant protein inhibits tumor growth and induces apoptosis through inhibiting Bcl-2 expression, triggering inflammatory responses and activating C-erbB-2 and Cox-2 expression in breast cancer mouse model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30266138&form=6&db=m Corrigendum to "AMP-activated protein kinase mediates T cell activation-induced expression of FasL and COX-2 via protein kinase C theta-dependent pathway in human Jurkat T leukemia cells" [Cell. Signal. 24 (2012) 1195-1207]. diagnostic usage,unassigned 3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683818&form=6&db=m The cyclooxygenase-2/prostaglandin E2 pathway and its role in the pathogenesis of human and dog hematological malignancies. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31349508&form=6&db=m Design of colloidal drug carriers of celecoxib for use in treatment of breast cancer and leukemia. therapeutic application,unassigned 1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31982141&form=6&db=m Adipose tissue-derived stromal cells retain immunosuppressive and angiogenic activity after coculture with cord blood hematopoietic precursors. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31985381&form=6&db=m Fractions of Boswellia serrata suppress LTA4, LTC4, Cyclooxygenase-2 activities and mRNA in HL-60 Cells and reduce lung inflammation in BALB/c mice. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32581782&form=6&db=m Pharmacological Activity, Pharmacokinetics, and Toxicity of Timosaponin AIII, a Natural Product Isolated From Anemarrhena asphodeloides Bunge: A Review. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33808594&form=6&db=m Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34179058&form=6&db=m ?-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota. diagnostic usage,unassigned 3,0
1.14.99.1 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1633871&form=6&db=m Induction of thromboxane synthase and prostaglandin endoperoxide synthase mRNAs in human erythroleukemia cells by phorbol ester. ongoing research,unassigned 4,0
1.14.99.1 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8443239&form=6&db=m Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation. ongoing research,unassigned 4,0
1.14.99.1 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18549804&form=6&db=m Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells. causal interaction,unassigned 2,0
1.14.99.1 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357584&form=6&db=m Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptoticeffect. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23435965&form=6&db=m Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25997834&form=6&db=m Berberis libanotica extract targets NF-?B/COX-2, PI3K/Akt and mitochondrial/caspase signalling to induce human erythroleukemia cell apoptosis. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26739353&form=6&db=m Two COX-2 inhibitors induce apoptosis in human erythroleukemia K562cells by modulating NF-?B and FHC pathways. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Leukemia, Erythroblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28591945&form=6&db=m [Effect of IFN-?2b on COX-2 and Angiogenesis in JAK2V617F Mutation Myeloproliferative Neoplasms]. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Leukemia, Feline http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29788832&form=6&db=m Feline injection site sarcoma: immunohistochemical characteristics. diagnostic usage,unassigned 2,0
1.14.99.1 Leukemia, Feline http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30941311&form=6&db=m Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14646349&form=6&db=m Apoptosis induced by molecular targeting therapy in hematological malignancies. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15359658&form=6&db=m COX-2 inhibitory treatment in chronic lymphocytic leukemia: a preliminary clinical study. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16473553&form=6&db=m Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17668203&form=6&db=m Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. ongoing research,unassigned 2,0
1.14.99.1 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956662&form=6&db=m [Expression of cyclooxygenase-2 in bone marrow cells of chronic leukemia and its significance.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Leukemia, Lymphocytic, Chronic, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691115&form=6&db=m Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Leukemia, Lymphoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314473&form=6&db=m Potential pathogenetic implications of cyclooxygenase-2 overexpression in B chronic lymphoid leukemia cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911099&form=6&db=m Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956662&form=6&db=m [Expression of cyclooxygenase-2 in bone marrow cells of chronic leukemia and its significance.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691115&form=6&db=m Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18414055&form=6&db=m Induction of differentiation of human leukemia cells by combinations of COX inhibitors and 1,25-dihydroxyvitamin D3 involves Raf1 but not Erk 1/2 signaling. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Leukemia, Myeloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27486062&form=6&db=m TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15368354&form=6&db=m L-ascorbic acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. ongoing research,unassigned 3,0
1.14.99.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15547942&form=6&db=m Arsenic trioxide represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825968&form=6&db=m Vascular endothelial growth factor-c (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20237399&form=6&db=m Cyclooxygenase-2, prostaglandin E2 and acute myeloid leukemia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21848701&form=6&db=m Functional Genetic Variations of Cyclooxygenase-2 and Susceptibility to Acute Myeloid Leukemia in a Chinese Population. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24989281&form=6&db=m [Effect of COX-2 inhibitor celecoxib on proliferation, apoptosis of HL-60 cells and its mechanism]. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26342105&form=6&db=m IL-18-induced interaction between IMP3 and HuR contributes to COX-2 mRNA stabilization in acute myeloid leukemia. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15190260&form=6&db=m Cyclooxygenase-1, but not -2, is upregulated in NB4 leukemic cells and human primary promyelocytic blasts during differentiation. ongoing research,unassigned 4,0
1.14.99.1 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18354491&form=6&db=m Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31349508&form=6&db=m Design of colloidal drug carriers of celecoxib for use in treatment of breast cancer and leukemia. therapeutic application,unassigned 1,0
1.14.99.1 Leukemia, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745483&form=6&db=m Constitutive expression of the cyclooxygenase-2 gene in T-cell lines infected with human T cell leukemia virus type I. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3470394&form=6&db=m Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis. unassigned -
1.14.99.1 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11867678&form=6&db=m Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Leukocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31825424&form=6&db=m Microalgae aqueous extracts exert intestinal protective effects in Caco-2 cells and dextran sodium sulphate-induced mouse colitis. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Leukoencephalopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25957909&form=6&db=m COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1
1.14.99.1 Leukomalacia, Periventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26781425&form=6&db=m COX-1 and COX-2 polymorphisms in susceptibility to cerebral palsy in very preterm infants. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Leukopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2591030&form=6&db=m Prevention of the toxic action of tumor necrosis factor by cyclooxygenase inhibitor and leukopenia. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Leukopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7846692&form=6&db=m Haemodynamic and haematologic effects of Acanthaster planci venom in dogs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Leukopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15631041&form=6&db=m Expression of the cyclooxygenase isoforms in the prodromal stage of black walnut-induced laminitis in horses. diagnostic usage,unassigned 1,0
1.14.99.1 Leukopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808144&form=6&db=m Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Leukopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29440919&form=6&db=m Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Leukopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33254437&form=6&db=m Elucidation of the molecular mechanism of Sanguisorba Officinalis L. against leukopenia based on network pharmacology. therapeutic application,unassigned 1,0
1.14.99.1 Leukopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33553396&form=6&db=m Clinical benefit of COX-2 inhibitors in the adjuvant chemotherapy of advanced non-small cell lung cancer: A systematic review and meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Leukoplakia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014004&form=6&db=m NSAIDs for the chemoprevention of oral cancer: promise or pessimism?: Commentary re J. L. Mulshine et al., randomized, double-blind, placebo-controlled, phase IIB trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia. Clin. Cancer Res., 10: 1565-1573, 2004. therapeutic application,unassigned 4,0
1.14.99.1 Leukoplakia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014005&form=6&db=m Randomized, double-blind, placebo-controlled phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Leukoplakia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20599939&form=6&db=m Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Leukoplakia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26960457&form=6&db=m The role of Ki-67, p16, CD34, Bcl-2, cyclooxygenase-2 in the pathogenesis of proliferative verrucous leukoplakia. causal interaction,unassigned 1,0
1.14.99.1 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070598&form=6&db=m Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203806&form=6&db=m Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252927&form=6&db=m COX-2 inhibition in upper aerodigestive tract tumors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15886845&form=6&db=m [The expressions of cyclooxygenase-2 (Cox-2),VEGF in oral squamous cell carcinoma and precancerous lesions and their significances] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202791&form=6&db=m Differential effects of selective cyclooxygenase-2 inhibitors in inhibiting proliferation and induction of apoptosis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258542&form=6&db=m Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20599939&form=6&db=m Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22665749&form=6&db=m Comparison of COX2 expression between oral squamous cell carcinoma, leukoplakia and normal mucosa. ongoing research,unassigned 3,0
1.14.99.1 Leukoplakia, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26229582&form=6&db=m Cyclooxygenase-2 and Ki67 Expression in Oral Leukoplakia: a Clinicopathological Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17259381&form=6&db=m Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. causal interaction,unassigned 2,0
1.14.99.1 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18274606&form=6&db=m Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. causal interaction,unassigned 3,0
1.14.99.1 Leukostasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20071676&form=6&db=m Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Leydig Cell Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18619641&form=6&db=m COX-2 gene polymorphisms and protein expression in renomedullary interstitial cell tumors. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Leydig Cell Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31876249&form=6&db=m Renal interstitial cell tumor in a dog: clinicopathologic, imaging, and histologic features. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Lichen Planus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21923838&form=6&db=m DNA polymorphisms and tissue cyclooxygenase-2 expression in oral lichen planus: a case-control study. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Lichen Planus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25980490&form=6&db=m The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus. causal interaction,unassigned 4,0
1.14.99.1 Lichen Planus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31211042&form=6&db=m Expression of Ki-67, p53, ?-SMA and COX-2 in lichen planus and related lesions: A pilot study. therapeutic application,unassigned 1,0
1.14.99.1 Lichen Planus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31218676&form=6&db=m Immunohistochemical evaluation of the effect of acitretin and systemic steroid treatments on Ki-67, Bcl-2, and COX-2 levels in cutaneous lichen planus patients. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17530268&form=6&db=m DNA content, Cyclooxygenase-2 expression and loss of E-cadherin expression do not predict risk of malignant transformation in oral lichen planus. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18536521&form=6&db=m COX-2 expression in oral lichen planus. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21923838&form=6&db=m DNA polymorphisms and tissue cyclooxygenase-2 expression in oral lichen planus: a case-control study. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22017396&form=6&db=m Increased levels of COX-2 in oral lichen planus supports an autoimmune cause of the disease. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416899&form=6&db=m Increased levels of COX-2 and oral lichen planus. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22429324&form=6&db=m Reply to increased levels of COX-2 and oral lichen planus by P.D. Pigatto, F. Spaderi, G.P. Bombeccari, G. Guzzi by Danielsson et al. unassigned -
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23790336&form=6&db=m COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24834112&form=6&db=m Expression of COX-2 and bcl-2 in oral lichen planus lesions and lichenoid reactions. causal interaction,unassigned 4,0
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27889928&form=6&db=m Elucidating the role of Cyclooxygenase-2 in the pathogenesis of oral lichen planus - an immunohistochemical study with supportive histochemical analysis. ongoing research,unassigned 4,0
1.14.99.1 Lichen Planus, Oral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30894979&form=6&db=m Increased cyclooxygenase 2 expression in association with oral lichen planus severity. causal interaction,unassigned 3,0
1.14.99.1 Lichen Sclerosus et Atrophicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766245&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in non-neoplastic and neoplastic vulvar epithelial lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 linoleate 13s-lipoxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3487975&form=6&db=m Acquired von Willebrand disease and storage pool disease in chronic myelocytic leukemia. diagnostic usage,unassigned 3,0
1.14.99.1 linoleate 13s-lipoxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6799826&form=6&db=m Deficiency of platelet lipoxygenase activity in myeloproliferative disorders. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lipomatosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34141803&form=6&db=m Pelvic lipomatosis with cystitis glandularis managed with cyclooxygenase-2 inhibitor: A case report. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Liposarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973067&form=6&db=m Relationship of endothelial area with VEGF-A, COX-2, maspin, c-KIT, and DOG-1 immunoreactivity in liposarcomas versus non-lipomatous soft tissue tumors. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Liver Abscess, Amebic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11070250&form=6&db=m Entamoeba histolytica induces cyclooxygenase-2 expression in macrophages during amebic liver abscess formation. ongoing research,unassigned 1,0
1.14.99.1 Liver Abscess, Amebic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172219&form=6&db=m Entamoeba histolytica: induction of cyclooxygenase-2 expression during amoebic liver abscess formation in hamsters (Mesocricetus auratus). causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Liver Abscess, Amebic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16647055&form=6&db=m Entamoeba histolytica: inflammatory process during amoebic liver abscess formation involves cyclooxygenase-2 expression in macrophages and trophozoites. causal interaction,unassigned 3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1332454&form=6&db=m Eicosanoid production by density-defined human peritoneal macrophages during inflammation. unassigned -
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2919584&form=6&db=m Effect of renal prostaglandins on survival in patients with liver cirrhosis. ongoing research,unassigned 4,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10535701&form=6&db=m Interaction between prostanoids and nitric oxide in the control of tubular function in rats with chronic bile duct ligation. unassigned -
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12076714&form=6&db=m Expression of cyclooxygenase 2 and cytosolic phospholipase A(2) in the liver tissue of patients with chronic hepatitis and liver cirrhosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12372403&form=6&db=m Inhibition of the expression of alpha-smooth muscle actin in human hepatic stellate cell line, LI90, by a selective cyclooxygenase 2 inhibitor, NS-398. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891558&form=6&db=m JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15047734&form=6&db=m Distribution of constitutive (COX-1) and inducible (COX-2) cyclooxygenase in postviral human liver cirrhosis: a possible role for COX-2 in the pathogenesis of liver cirrhosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15377291&form=6&db=m Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15876570&form=6&db=m The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17565644&form=6&db=m Antifibrotic activity of rofecoxib in vivo is associated with reduced portal hypertension in rats with carbon tetrachloride-induced liver injury. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18420326&form=6&db=m Corn oil enhancing hepatic lipid peroxidation induced by CCl4 does not aggravate liver fibrosis in rats. therapeutic application,unassigned 1,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462380&form=6&db=m Effect of selective cyclooxygenase-2 inhibitor meloxicam on liver fibrosis in rats with ligated common bile ducts. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18503750&form=6&db=m Elucidation of the role of COX-2 in liver fibrogenesis using transgenic mice. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19007904&form=6&db=m Celecoxib exacerbates hepatic fibrosis and induces hepatocellular necrosis in rats treated with porcine serum. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250220&form=6&db=m Cyclooxygenase-2 expression in chronic liver diseases and hepatocellular carcinoma: an immunohistochemical study . causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19397970&form=6&db=m Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20524983&form=6&db=m Antifibrotic and fibrolytic properties of celecoxib in liver damage induced by carbon tetrachloride in the rat. ongoing research,unassigned 3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21319995&form=6&db=m Association Between Single Nucleotide Polymorphisms in the Cyclooxygenase-2, Tumor Necrosis Factor-?, and Vascular Endothelial Growth Factor-A Genes, and Susceptibility to Hepatocellular Carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21452284&form=6&db=m Microglia activation in hepatic encephalopathy. ongoing research,unassigned 2,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22131058&form=6&db=m Immunodetection of cyclooxygenase-2 (COX-2) is restricted to tissue macrophages in normal rat liver and to recruited mononuclear phagocytes in liver injury and cholangiocarcinoma. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22168377&form=6&db=m Celecoxib, a selective cyclooxygenase-2 inhibitor, lowers plasma cholesterol and attenuates hepatic lipid peroxidation during carbon-tetrachloride-associated hepatotoxicity in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340386&form=6&db=m Cyclooxygenase-2 promoter polymorphism -899G/C is associated with hepatitis B-related liver cancer in a Chinese population of Gansu province. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22381741&form=6&db=m Sulfasalazine prevents the increase in TGF-?, COX-2, nuclear NF?B translocation and fibrosis in CCl4-induced liver cirrhosis in the rat. unassigned -
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24844967&form=6&db=m [Role of cyclooxygenase 2 and its inhibitor valdecoxib in liver fibrosis]. ongoing research,unassigned 2,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25168399&form=6&db=m Suppression of oxidative stress and improvement of liver functions in mice by ursolic acid via LKB1-AMP-activated protein kinase signaling. ongoing research,unassigned 1,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26619541&form=6&db=m [The Expressions of Somatostatin and Cycloxygenase-2 in Chronic Hepatitis, Hepatic Cirrhosis, Precancerous Lesion and Hepatocellular Carcinoma]. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27056726&form=6&db=m Inhibition of cyclooxygenase-2 alleviates liver cirrhosis via improvement of the dysfunctional gut-liver axis in rats. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27321932&form=6&db=m Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28259935&form=6&db=m Expression of cyclooxygenase-2 is correlated with lncRNA-COX-2 in cirrhotic mice induced by carbon tetrachloride. causal interaction,unassigned 3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449186&form=6&db=m The risk of lower gastrointestinal bleeding in low-dose aspirin users. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29174446&form=6&db=m Protective effect of ethyl acetate fraction of Drynaria quercifolia against CCl unassigned -
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29234949&form=6&db=m Curc-mPEG454, a PEGylated Curcumin Derivative, Improves Anti-inflammatory and Antioxidant Activities: a Comparative Study. ongoing research,unassigned 1,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29990893&form=6&db=m Investigation of the hepatoprotective effect of Corydalis saxicola Bunting on carbon tetrachloride-induced liver fibrosis in rats by 1H-NMR-based metabonomics and network pharmacology approaches. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30038293&form=6&db=m Cyclooxygenase-2 up-regulates hepatic somatostatin receptor 2 expression. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30139224&form=6&db=m The Association of PNPLA3, COX-2 and DHCR7 Polymorphisms with Advanced Liver Fibrosis in Patients with HCV Mono- Infection and HCV/HIV Co-Infection causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32184095&form=6&db=m COX-2 in liver fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32725034&form=6&db=m Preventive effect of ethanol extract from Chinese sumac fruits against tetrachloromethane-induced liver fibrosis in mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32821072&form=6&db=m Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34034779&form=6&db=m Involvement of TLR4 signaling regulated-COX2/PGE2 axis in liver fibrosis induced by Schistosoma japonicum infection. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145945&form=6&db=m Inhibition of cyclooxygenase-2 enhanced intestinal epithelial homeostasis via suppressing ?-catenin signalling pathway in experimental liver fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34301291&form=6&db=m Insights into the molecular mechanisms of Huangqi decoction on liver fibrosis via computational systems pharmacology approaches. therapeutic application,unassigned 1,0
1.14.99.1 Liver Cirrhosis, Biliary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584358&form=6&db=m Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2936143&form=6&db=m Renal effects of cyclooxygenase and thromboxane synthetase inhibitors in dogs with experimental liver disease and in rats with glomerulonephritis. ongoing research,unassigned 4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3315934&form=6&db=m Renal eicosanoids as determinants of renal function in liver disease. causal interaction,unassigned 3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3511684&form=6&db=m Renal prostaglandins and the control of renal function in liver disease. therapeutic application,unassigned 3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9397995&form=6&db=m Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat. ongoing research,unassigned 1,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594587&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase in omental arteries harvested from patients with severe liver diseases: immuno-localization and influence on vascular tone. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12751752&form=6&db=m Renal effects of selective cyclooxygenase inhibition in experimental liver disease. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12879991&form=6&db=m Hepatotoxicity associated with non-steroidal anti-inflammatory drugs. therapeutic application,unassigned 3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14580367&form=6&db=m Cyclooxygenase 2 (COX2)-prostanoid pathway and liver diseases. unassigned -
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678698&form=6&db=m [Role of cyclooxygenase-2 in the pathogenesis of chronic liver diseases] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218507&form=6&db=m Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15479690&form=6&db=m Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15633605&form=6&db=m Pharmaceutical reversal of insulin resistance. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16513083&form=6&db=m Bile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16557554&form=6&db=m COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17766677&form=6&db=m Comparative protection against liver inflammation and fibrosis by a selective cyclooxygenase-2 inhibitor and a nonredox-type 5-lipoxygenase inhibitor. ongoing research,unassigned 3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18092051&form=6&db=m Expression of cyclooxygenase-2 and transforming growth factor-beta1 in HCV-induced chronic liver disease and hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18423164&form=6&db=m [An experimental study on the expression and pathogenic effects of cyclooxygenase-2 in nonalcoholic fatty liver disease] ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462380&form=6&db=m Effect of selective cyclooxygenase-2 inhibitor meloxicam on liver fibrosis in rats with ligated common bile ducts. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250220&form=6&db=m Cyclooxygenase-2 expression in chronic liver diseases and hepatocellular carcinoma: an immunohistochemical study . causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912698&form=6&db=m [Study on the mechanism of preventing alcholic liver disease by selective cyclooxygenase 2 inhibitor] therapeutic application,unassigned 4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20084600&form=6&db=m Cyclooxygenase-2 Overexpression is Associated with Clinical Outcome in Biliary Atresia. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20196963&form=6&db=m [The roles of cyclooxygenase-2 and 5-lipoxygenase in liver disease] unassigned -
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20880066&form=6&db=m Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21059296&form=6&db=m [Relationship between single nucleotide polymorphisms in the promoter of COX-2 gene and hereditariness to NAFLD]. ongoing research,unassigned 4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21356386&form=6&db=m Transgenic mice expressing cyclooxygenase-2 in hepatocytes reveal a minor contribution of this enzyme to chemical hepatocarcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22168377&form=6&db=m Celecoxib, a selective cyclooxygenase-2 inhibitor, lowers plasma cholesterol and attenuates hepatic lipid peroxidation during carbon-tetrachloride-associated hepatotoxicity in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22330637&form=6&db=m Increased hepatic expression of TLR2 and TLR4 in the hepatic inflammation-fibrosis-carcinoma sequence. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22863264&form=6&db=m Genetic polymorphism in cyclooxygenase-2 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25432964&form=6&db=m Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. unassigned -
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27189282&form=6&db=m Cyclooxygenase-2 Inhibitor Reduces Hepatic Stiffness in Pediatric Chronic Liver Disease Patients Following Kasai Portoenterostomy. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27227672&form=6&db=m Contribution of Cyclooxygenase End Products and Oxidative Stress to Intrahepatic Endothelial Dysfunction in Early Non-Alcoholic Fatty Liver Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27321932&form=6&db=m Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28187366&form=6&db=m A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice. therapeutic application,unassigned 4,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28611510&form=6&db=m Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives. unassigned -
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28959557&form=6&db=m Apocynin reduced doxycycline-induced acute liver injury in ovariectomized mice. ongoing research,unassigned 3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155948&form=6&db=m Protective role of hepatocyte cyclooxygenase-2 expression against liver ischemia-reperfusion injury in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31342715&form=6&db=m [Effects of ellagic acid on inflammation and oxidative stress induced by AKT gene transfection in mice with fatty liver disease]. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32184095&form=6&db=m COX-2 in liver fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32953015&form=6&db=m A molecular-logic gate for COX-2 and NAT based on conformational and structural changes: visualizing the progression of liver disease. unassigned -
1.14.99.1 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33657087&form=6&db=m A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model. causal interaction,unassigned 1,0
1.14.99.1 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=447034&form=6&db=m Effect of indomethacin and prostaglandin A1 on renal function and plasma renin activity in alcoholic liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9041257&form=6&db=m Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648422&form=6&db=m [The role of cyclooxygenase-2 in the pathogenesis of alcoholic liver diseases] causal interaction,unassigned 4,0
1.14.99.1 Liver Diseases, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15387921&form=6&db=m [The activation of nuclear factor kappa B and the expression of cyclooxygenase-2 in alcoholic liver disease in rats] causal interaction,unassigned 1,0
1.14.99.1 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17407721&form=6&db=m [A study on the role of cyclooxygenase-2 in lipopolysaccharide mediated fulminate hepatic failure] ongoing research,unassigned 3,0
1.14.99.1 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17538762&form=6&db=m Nimesulide-induced hepatotoxicity and fatal hepatic failure. unassigned -
1.14.99.1 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19585617&form=6&db=m Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Liver Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22152242&form=6&db=m [Expression of COX-2 and PPARr in the livers of patients with acute on chronic HBV-related liver failure and their relationship with clinic parameters]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1
1.14.99.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12021934&form=6&db=m COX-2 inhibitor (nimesulide) induced acute liver failure. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12594587&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase in omental arteries harvested from patients with severe liver diseases: immuno-localization and influence on vascular tone. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19017995&form=6&db=m Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure. ongoing research,unassigned 4,0
1.14.99.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19950766&form=6&db=m [Cholestatic hepatitis associated with nimesulide--a case report] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575628&form=6&db=m Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24149188&form=6&db=m Hepatic encephalopathy: effects of liver failure on brain function. causal interaction,unassigned 3,0
1.14.99.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24440378&form=6&db=m N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism. therapeutic application,unassigned 4,0
1.14.99.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27580512&form=6&db=m Role of cyclooxygenase isoforms in encephalopathy of cirrhotic rats. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Liver Failure, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34268031&form=6&db=m The Modulating Effect of Ursodeoxycholic Acid on Liver Tissue Cyclooxygenase-2 Expression Following Extended Hepatectomy. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10228831&form=6&db=m Cyclooxygenase-2 expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11915030&form=6&db=m The MDR phenotype is associated with the expression of COX-2 and iNOS in a human hepatocellular carcinoma cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12939602&form=6&db=m Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15633216&form=6&db=m Specific COX-2 inhibitor NS398 induces apoptosis in human liver cancer cell line HepG2 through BCL-2. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878334&form=6&db=m Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15918970&form=6&db=m [The effects of adenovirus-mediated human COX-2 antisense RNA on the growth of hepatocellular carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273635&form=6&db=m Effects of adenovirus-mediated human cyclooxygenase-2 antisense RNA on the growth of hepatocellular carcinoma. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16613672&form=6&db=m [Inhibitory Effects of Cyclooxygenase-2 Inhibitor Celecoxib on Growth and Angiogenesis of Human Liver Cancer HepG2 Cell Xenografts in Small Nude Mice.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16800815&form=6&db=m Cyclo-oxygenase 2 expression impairs serum-withdrawal-induced apoptosis in liver cells. causal interaction,unassigned 3,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16937518&form=6&db=m Cyclooxygenases in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17846040&form=6&db=m Correlations between cyclooxygenase-2 expression and angiogenic factors in primary tumors and liver metastases in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17914586&form=6&db=m Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18424914&form=6&db=m Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18722373&form=6&db=m E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21800055&form=6&db=m Cyclooxygenase-2 -765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22073004&form=6&db=m Bioactive cembranoids from the soft coral Sinularia crassa. diagnostic usage,unassigned 1,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340386&form=6&db=m Cyclooxygenase-2 promoter polymorphism -899G/C is associated with hepatitis B-related liver cancer in a Chinese population of Gansu province. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26136881&form=6&db=m Cidan inhibits liver cancer cell growth by reducing COX-2 and VEGF expression and cell cycle arrest. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26758420&form=6&db=m Activated hepatic stellate cells promote liver cancer by induction of myeloid-derived suppressor cells through cyclooxygenase-2. ongoing research,unassigned 2,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26984380&form=6&db=m Regulation of COX-2 expression and epithelial-to-mesenchymal transition by hypoxia-inducible factor-1? is associated with poor prognosis in hepatocellular carcinoma patients post TACE surgery. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28246472&form=6&db=m Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,4
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28728977&form=6&db=m Synthesis and characterization of boron fenbufen and its F-18 labeled homolog for boron neutron capture therapy of COX-2 overexpressed cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,2
1.14.99.1 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32085269&form=6&db=m A novel anti-tumorigenic mechanism by herbal extract saikosaponin-d through p-STAT3/C/EBP? signaling suppression of COX-2 in liver cancer. therapeutic application,unassigned 1,0
1.14.99.1 Lordosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10371676&form=6&db=m Cytokines inhibit sexual behavior in female rats: II. Prostaglandins mediate the suppressive effects of interleukin-1beta. therapeutic application,unassigned 3,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7733353&form=6&db=m Role of cyclooxygenase inhibition and hyperoxia in regulating pulmonary perfusion in dogs. ongoing research,unassigned 3,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12349896&form=6&db=m Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-kappaB activation in A549 cells. therapeutic application,unassigned 3,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15127973&form=6&db=m Cyclooxygenase-2 is up-regulated in lung parenchyma of chronic obstructive pulmonary disease and down-regulated in idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863442&form=6&db=m The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16603593&form=6&db=m Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases. causal interaction,unassigned 3,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19577709&form=6&db=m Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19616539&form=6&db=m Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20720307&form=6&db=m Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22284694&form=6&db=m Failure of a repeat course of cyclooxygenase inhibitor to close a PDA is a risk factor for developing chronic lung disease in ELBW infants. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23046591&form=6&db=m The association between the use of non-steroidal anti-inflammatory drugs and atrial fibrillation: A nationwide case-control study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23742950&form=6&db=m Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27188849&form=6&db=m Altered Cyclooxygenase-2 Expression in Pulmonary Sarcoidosis is not Related to Clinical Classifications. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27288489&form=6&db=m AdipoR-increased intracellular ROS promotes cPLA2 and COX-2 expressions via activation of PKC and p300 in adiponectin-stimulated human alveolar type II cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27381367&form=6&db=m The principal pathways involved in the in vivo modulation of hypoxic pulmonary vasoconstriction, pulmonary arterial remodelling and pulmonary hypertension. causal interaction,unassigned 4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1335454&form=6&db=m Mechanisms of increased pulmonary microvascular permeability induced by FMLP in isolated rabbit lungs. unassigned -
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1537723&form=6&db=m Blunted hypoxic vasoconstriction in oleic acid lung injury: effect of cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1546845&form=6&db=m The role of cyclooxygenase products in lung injury induced by tumor necrosis factor in sheep. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1607684&form=6&db=m Effect of cyclooxygenase inhibition on amphotericin B-induced lung injury in awake sheep. therapeutic application,unassigned 1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1885440&form=6&db=m Neutrophil-associated lung injury after the infusion of activated plasma. causal interaction,unassigned 3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900402&form=6&db=m Inhibition of cyclooxygenase metabolite production attenuates ischemia-reperfusion lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1909312&form=6&db=m Cyclooxygenase pathway mediates lung injury induced by phorbol and platelets. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2361733&form=6&db=m Phospholipase A2-induced lung edema and its mechanism in isolated perfused guinea pig lung. ongoing research,unassigned 1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2501283&form=6&db=m Endotoxin-induced lung injury in rats: role of eicosanoids. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2513310&form=6&db=m Control of shunt pathway perfusion in diffuse granulomatous lung disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2702843&form=6&db=m Prostaglandin E1 infusion fails to prevent hyperoxic lung injury in adult rabbits. causal interaction,unassigned 3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2831433&form=6&db=m Eicosanoids are involved in the permeability changes but not the pulmonary hypertension after systemic activation of complement. therapeutic application,unassigned 4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3102855&form=6&db=m Beneficial effects of ibuprofen in oleic acid induced lung injury. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3113757&form=6&db=m Oleic acid induces pulmonary injury independent of eicosanoids in the isolated, perfused rabbit lung. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3144200&form=6&db=m The role of cyclooxygenase and lipoxygenase mediators in oxidant-induced lung injury. causal interaction,unassigned 2,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3311720&form=6&db=m Acute cigarette smoke exposure causes lung injury in rabbits treated with ibuprofen. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3538956&form=6&db=m Ibuprofen prevents synthetic smoke-induced pulmonary edema. therapeutic application,unassigned 1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3917940&form=6&db=m Arachidonate cyclooxygenase metabolites as mediators of complement-initiated lung injury. causal interaction,unassigned 2,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8045846&form=6&db=m Inhibition of eicosanoids does not prevent neutrophil injury from phorbol in isolated rabbit lung. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8093999&form=6&db=m Pharmacologic reduction in tumor necrosis factor activity of pulmonary alveolar macrophages. therapeutic application,unassigned 4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8095224&form=6&db=m Evidence for peroxidase-mediated metabolism of cyclophosphamide. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8393000&form=6&db=m Leukotriene B4 induces lung injury in the rabbit: role of neutrophils and effect of indomethacin. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8493358&form=6&db=m Cecal ligation and puncture is associated with pulmonary injury in the rat: role of cyclooxygenase pathway products. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8588068&form=6&db=m Insights into IgE-mediated lung inflammation derived from a study employing a 5-lipoxygenase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8967523&form=6&db=m Effects of acute and chronic hypoxia on rat lung cyclooxygenase. causal interaction,unassigned 4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9230729&form=6&db=m Site of pulmonary vasodilation by inhaled nitric oxide in microembolic lung injury. causal interaction,unassigned 3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9550130&form=6&db=m Cyclooxygenase metabolites possibly produced by endothelial cells mediate the lung injury caused by mechanically stimulated leukocytes. unassigned -
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10030848&form=6&db=m Bacterial lipopolysaccharide induction of the prostaglandin G/H synthase 2 gene causes thromboxane-dependent pulmonary hypertension in rabbits. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10228099&form=6&db=m Inhibition of cyclooxygenase and nitric oxide synthase in hypoxic vasoconstriction and oleic acid-induced lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10660836&form=6&db=m Increased expression of cyclooxygenase 2 mediates oil fly ash-induced lung injury. causal interaction,unassigned 3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10751353&form=6&db=m Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge: differential regulation in the various types of cells in the lung. causal interaction,unassigned 3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179120&form=6&db=m Granulocyte-macrophage colony-stimulating factor amplifies lipopolysaccharide-induced bronchoconstriction by a neutrophil- and cyclooxygenase 2-dependent mechanism. causal interaction,unassigned 4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356794&form=6&db=m Systemic and lung physiological changes in rats after intravascular activation of complement. unassigned -
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11373473&form=6&db=m Influence of cyclooxygenase and lipoxygenase inhibitors on oxidative stress-induced lung injury. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11493780&form=6&db=m Macrophage cyclooxygenase expression, immunosuppression, and cardiopulmonary dysfunction after blunt chest trauma. causal interaction,unassigned 3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11570677&form=6&db=m Reactive oxygen species and molecular mechanism of silica-induced lung injury. causal interaction,unassigned 1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11811922&form=6&db=m Diseases caused by silica: mechanisms of injury and disease development. ongoing research,unassigned 2,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992649&form=6&db=m Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12360491&form=6&db=m Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12381531&form=6&db=m Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15509536&form=6&db=m Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15730936&form=6&db=m Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16032457&form=6&db=m Effect of cyclooxygenase-2 inhibitor pretreatment on gas exchange after hydrochloric acid aspiration in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16492981&form=6&db=m Inhibition of COX-2 Aggravates Neutrophil Migration and Pneumocyte Apoptosis in Surfactant-Depleted Rat Lungs. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17035596&form=6&db=m Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids. causal interaction,unassigned 1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050069&form=6&db=m COX-2 is widely expressed in metaplastic epithelium in pulmonary fibrous disorders. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18216604&form=6&db=m Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat. unassigned -
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18249557&form=6&db=m Protective effect of Arbutus unedo aqueous extract in carrageenan-induced lung inflammation in mice. ongoing research,unassigned 2,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18854985&form=6&db=m S-nitroso human serum albumin given after LPS challenge reduces acute lung injury and prolongs survival in a rat model of endotoxemia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776691&form=6&db=m S-nitroso-human-albumin: a new therapeutic approach in endotoxic shock. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20213072&form=6&db=m Hypercapnic acidosis in ventilator-induced lung injury. ongoing research,unassigned 1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20422273&form=6&db=m Cycloxygenase Inhibition Enhances the Effects of Surfactant Therapy in Endotoxin-Induced Rat Model of ARDS. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20578675&form=6&db=m Immunohistochemical analysis of the COX-2 marker in acute pulmonary injury in rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20883710&form=6&db=m Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard. causal interaction,unassigned 4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21944479&form=6&db=m Protective Role of Cyclooxygenase (COX)-2 in Experimental Lung Injury: Evidence of a Lipoxin A(4)-Mediated Effect. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22556158&form=6&db=m The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22859522&form=6&db=m MMP19 is a Key Regulator of Lung Fibrosis in Mice and Humans. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23521748&form=6&db=m Bile acids increase alveolar epithelial permeability via MAP kinase, cytosolic phospholipase A2 , cyclooxygenase-2, PGE2 and junctional proteins. causal interaction,unassigned 4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23587488&form=6&db=m Effects of COX-2 inhibitor on ventilator-induced lung injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23624331&form=6&db=m Cyclooxygenase-2 in newborn hyperoxic lung injury. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24273102&form=6&db=m Cyclooxygenase-2 inhibition partially protects against 60% O2 -mediated lung injury in neonatal rats. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26122220&form=6&db=m MELATONIN ALLEVIATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN MICE. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26221218&form=6&db=m Amelioration of meconium-induced acute lung injury by parecoxib in a rabbit model. causal interaction,unassigned 4,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26520688&form=6&db=m Acanthopanax trifoliatus inhibits lipopolysaccharide-induced inflammatory response in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26724476&form=6&db=m COX-2 inhibition attenuates lung injury induced by skeletal muscle ischemia reperfusion in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28081626&form=6&db=m Scutellaria baicalensis Ameliorates Acute Lung Injury by Suppressing Inflammation In Vitro and In Vivo. causal interaction,unassigned 1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28356130&form=6&db=m Parecoxib reduced ventilation induced lung injury in acute respiratory distress syndrome. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28809447&form=6&db=m Pulmonary delivery of tea tree oil-?-cyclodextrin inclusion complexes for the treatment of fungal and bacterial pneumonia. therapeutic application,unassigned 1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29536762&form=6&db=m Altered expression of cyclooxygenase-2, 12-lipoxygenase, inducible nitric oxide synthase-2 and surfactant protein D in lungs of patients with pulmonary injury caused by sulfur mustard. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30200495&form=6&db=m Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice. causal interaction,unassigned 1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30605726&form=6&db=m GYY4137 attenuates LPS-induced acute lung injury via heme oxygenase-1 modulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34275859&form=6&db=m Potential therapeutic effects of avenanthramide-C against lung toxicity caused by silver nanoparticles injection in rats. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34372885&form=6&db=m Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706493&form=6&db=m Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391924&form=6&db=m Sensitivity of tumoricidal function in macrophages from different anatomical sites of cancer patients to modulation of arachidonic acid metabolism. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9515807&form=6&db=m Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731479&form=6&db=m Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823297&form=6&db=m Expression of cyclooxygenase-2 in human lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353732&form=6&db=m Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515422&form=6&db=m Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10605031&form=6&db=m Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10626810&form=6&db=m Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10665651&form=6&db=m Cyclooxygenase-2 (COX-2) mRNA expression levels in normal lung tissues and non-small cell lung cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728691&form=6&db=m Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10815926&form=6&db=m Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874016&form=6&db=m Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10935498&form=6&db=m Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. causal interaction,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062695&form=6&db=m Meloxicam inhibits the growth of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093779&form=6&db=m Induction of p27(KIP1) as a mechanism underlying NS398-induced growth inhibition in human lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156228&form=6&db=m Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11208460&form=6&db=m Helicobacter pylori, gastrin and cyclooxygenase-2 in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309334&form=6&db=m Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11320076&form=6&db=m Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11439906&form=6&db=m [Suppressive efffects of clarithromycin and cyclooxygenase-2 inhibitor, etodolac on N-nitrosobis(2-hydroxypropyl)amine(BHP)- induced experimental lung neoplasm in rats] ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11464289&form=6&db=m Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11494020&form=6&db=m Co-expression of beta-adrenergic receptors and cyclooxygenase-2 in pulmonary adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595687&form=6&db=m A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605058&form=6&db=m Cyclooxygenase-2 level and culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11728453&form=6&db=m Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830527&form=6&db=m Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836568&form=6&db=m Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11850726&form=6&db=m Induction of cyclo-oxygenase-2 in non-small cell lung cancer cells by infection with DeltaE1, DeltaE3 recombinant adenovirus vectors. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882767&form=6&db=m Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11895880&form=6&db=m Hierarchical clustering of lung cancer cell lines using DNA methylation markers. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086404&form=6&db=m Increased expression of COX-2 in the development of human lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12114451&form=6&db=m Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130685&form=6&db=m Transcriptional regulation of basal cyclooxygenase-2 expression in murine lung tumor-derived cell lines by CCAAT/enhancer-binding protein and activating transcription factor/cAMP response element-binding protein. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297183&form=6&db=m Adenoid cystic carcinoma of the trachea and bronchus--a clinicopathologic study with DNA flow cytometric analysis and oncogene expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369871&form=6&db=m Selective cyclooxygenase-2 inhibitors and non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12391285&form=6&db=m Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393872&form=6&db=m Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12407775&form=6&db=m Cyclooxygenase 2-dependent regulation of antitumor immunity in lung cancer. therapeutic application,unassigned 1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12415697&form=6&db=m Localization of cyclooxygenase-2 protein expression in lung cancer specimens by immunohistochemical analysis. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12440624&form=6&db=m The role of COX-2 inhibitors in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499088&form=6&db=m Epidermal growth factor receptors and cyclooxygenase-2 in the pathogenesis of non-small cell lung cancer: potential targets for chemoprevention and systemic therapy. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576442&form=6&db=m Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591723&form=6&db=m Abnormal interleukin 10Ralpha expression contributes to the maintenance of elevated cyclooxygenase-2 in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631609&form=6&db=m Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12633561&form=6&db=m Cyclooxygenase-2 in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12660005&form=6&db=m Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12672646&form=6&db=m Protection by quercetin against cooking oil fumes-induced DNA damage in human lung adenocarcinoma CL-3 cells: role of COX-2. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686753&form=6&db=m Bee venom induces apoptosis and inhibits expression of cyclooxygenase-2 mRNA in human lung cancer cell line NCI-H1299. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12708493&form=6&db=m Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738712&form=6&db=m Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789263&form=6&db=m Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795053&form=6&db=m Cyclooxygenase-2 in lung cancer. causal interaction,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795056&form=6&db=m Potential for combined modality therapy of cyclooxygenase inhibitors and radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12867070&form=6&db=m Targeted therapies for stage III non-small cell lung cancer: integration in the combined modality setting. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12886870&form=6&db=m Irinotecan, cisplatin/carboplatin, and COX-2 inhibition in small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895344&form=6&db=m [Overexpression of COX-2 and its clinical significance in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902860&form=6&db=m COX-2 inhibitor as a radiation enhancer: new strategies for the treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958151&form=6&db=m Methanandamide increases COX-2 expression and tumor growth in murine lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530048&form=6&db=m Lung cancer and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14567645&form=6&db=m Evaluation of an aerosolized selective COX-2 inhibitor as a potentiator of doxorubicin in a non-small-cell lung cancer cell line. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14568683&form=6&db=m Correlation between cyclooxygenase-2 and tumor angiogenesis in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597555&form=6&db=m COX-2-dependent stabilization of survivin in non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14599301&form=6&db=m Role of cyclooxygenase-2 inhibitors in combination with radiation therapy in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14604894&form=6&db=m Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14609443&form=6&db=m Cyclooxygenase-2: a target for chemoprevention and treatment of non-small-cell lung cancer. therapeutic application,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14610920&form=6&db=m Emerging drugs for non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14640580&form=6&db=m Methanolic extract of adlay seed suppresses COX-2 expression of human lung cancer cells via inhibition of gene transcription. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654083&form=6&db=m Increased cyclooxygenase-2 (COX-2): a potential role in the pathogenesis of lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14662036&form=6&db=m The future of cyclooxygenase-2 inhibitors and other inhibitors of the eicosanoid signal pathway in the prevention and therapy of lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14676104&form=6&db=m Celecoxib modulates the capacity for prostaglandin E2 and interleukin-10 production in alveolar macrophages from active smokers. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14739609&form=6&db=m Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744769&form=6&db=m Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871987&form=6&db=m Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14967078&form=6&db=m Cyclooxygenase-2 inhibitors in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14971881&form=6&db=m Overexpression of cyclooxygenase-2 in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981580&form=6&db=m Improvement strategies for molecular targeting: Cyclooxygenase-2 inhibitors as radiosensitizers for non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996749&form=6&db=m Cyclooxygenase-2-dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010884&form=6&db=m Wikyungtang inhibits proliferation of A549 human lung cancer cells via inducing apoptosis and suppressing cyclooxygenase-2 activity. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15068324&form=6&db=m HER-2, EGFR, COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179623&form=6&db=m COX-2 inhibition and lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217531&form=6&db=m Cyclooxygenase-2 inhibitors as chemopreventive agents in lung cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217972&form=6&db=m Cyclooxygenase as a target in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15270659&form=6&db=m COX-2 and its inhibition as a molecular target in the prevention and treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15283156&form=6&db=m [Overexpression of COX-2 and a potential clinical application of its inhibitors in lung cancer] causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15284181&form=6&db=m Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15296859&form=6&db=m Multifaceted roles of cyclooxygenase-2 in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15315158&form=6&db=m The effects of nimesulide combined with cisplatin on lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15330186&form=6&db=m Survival in small cell lung cancer is independent of tumor expression of VEGF and COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332534&form=6&db=m [COX and study of cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374938&form=6&db=m Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374967&form=6&db=m Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15473933&form=6&db=m [Effect of cyclooxygenase-2,and matrix metalloproteinase-2 expression on prognosis of lung cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15485309&form=6&db=m Celecoxib: a novel treatment for lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494133&form=6&db=m Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494493&form=6&db=m Prostaglandin E2-dependent enhancement of tissue inhibitors of metalloproteinases-1 production limits dendritic cell migration through extracellular matrix. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501964&form=6&db=m Modulation of pulmonary leukotriene B4 production by cyclooxygenase-2 inhibitors and lipopolysaccharide. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15542809&form=6&db=m Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15572759&form=6&db=m Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. therapeutic application,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15587390&form=6&db=m Expression and significance of cyclooxygenase 2 gene in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622005&form=6&db=m Treatment of lung cancer using clinically relevant oral doses of the cyclooxygenase-2 inhibitor rofecoxib: potential value as adjuvant therapy after surgery. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685827&form=6&db=m Celecoxib and radiation therapy in non-small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15704107&form=6&db=m Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15734421&form=6&db=m Surgically induced accelerated local and distant tumor growth is significantly attenuated by selective COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15736413&form=6&db=m Effect of cyclooxygenase-2 antisense oligodeoxyribonucleotides in A-549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15765920&form=6&db=m Reactive oxygen species and lung tumorigenesis by mutant K-ras: a working hypothesis. therapeutic application,unassigned 2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15777967&form=6&db=m A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15777970&form=6&db=m Cyclooxygenase-2 protein levels are independent of epidermal growth factor receptor expression or activation in operable non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15825163&form=6&db=m COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15829319&form=6&db=m Adenovirus-uteroglobin suppresses COX-2 expression via inhibition of NF-kappaB activity in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15829328&form=6&db=m Docetaxel and cyclooxygenase-2 inhibition with celecoxib for advanced non-small cell lung cancer progressing after platinum-based chemotherapy: a multicenter phase II trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867233&form=6&db=m A phase I clinical trial of thoracic radiotherapy and concurrent celecoxib for patients with unfavorable performance status inoperable/unresectable non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870920&form=6&db=m Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878334&form=6&db=m Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15882925&form=6&db=m A genetic polymorphism in prostaglandin synthase 2 (8473, T-->C) and the risk of lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930356&form=6&db=m Chemotherapy induces the expression of cyclooxygenase-2 in non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15942563&form=6&db=m Evaluation of cyclooxygenase-2 inhibition in an orthotopic murine model of lung cancer for dose-dependent effect. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15950941&form=6&db=m IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15958566&form=6&db=m Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16002678&form=6&db=m Cyclooxygenase 2 inhibition promotes IFN-gamma-dependent enhancement of antitumor responses. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16005433&form=6&db=m Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16010430&form=6&db=m Induction of apoptosis by trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of cyclooxygenase-2 activity in human non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053662&form=6&db=m Targeting COX-2/PG-E2 with a COX-2 inhibitor in combination with chemotherapy for non-small cell lung cancer: are we ready for phase III? therapeutic application,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053664&form=6&db=m The combination of the selective cyclooxygenase-2 inhibitor celecoxib with weekly paclitaxel is a safe and active second-line therapy for non-small cell lung cancer: a phase II study with biological correlates. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055866&form=6&db=m COX-2 expression during early lung squamous cell carcinoma oncogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16098242&form=6&db=m Chemoprevention strategies with cyclooxygenase-2 inhibitors for lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16102610&form=6&db=m Cross-talk between cyclooxygenase-2 and epidermal growth factor receptor in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16119982&form=6&db=m Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136511&form=6&db=m COX-2 overexpression in canine tumors: potential therapeutic targets in oncology. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166442&form=6&db=m Targeting cyclooxygenase-2 in recurrent non-small cell lung cancer: a phase II trial of celecoxib and docetaxel. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16255988&form=6&db=m [Roles of cyclooxygenase-2 and caspase-3 expression in pathogenesis of lung carcinoma: an experiment with rats] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256796&form=6&db=m Dimethyl celecoxib as a novel non-cyclooxygenase 2 therapy in the treatment of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256823&form=6&db=m Association between cyclooxygenase and epidermal growth factor receptor pathways in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16278387&form=6&db=m Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376453&form=6&db=m COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16397057&form=6&db=m Celecoxib decreases Ki-67 proliferative index in active smokers. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16397226&form=6&db=m Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer. causal interaction,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16413115&form=6&db=m 9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16421596&form=6&db=m Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16497409&form=6&db=m Cytotoxicity of a non-cyclooxygenase-2 inhibitory derivative of celecoxib in non-small-cell lung cancer A549 cells. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16542464&form=6&db=m Relationship between cyclooxygenase 8473T>C polymorphism and risk of lung cancer: a case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16574063&form=6&db=m IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618538&form=6&db=m Cyclooxygenase inhibitors not inhibit resting lung cancer A549 cell proliferation. therapeutic application,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685393&form=6&db=m Interferon-alpha resistance can be reversed by inhibition of IFN-alpha-induced COX-2 expression potentially via STAT1 activation in A549 cells. ongoing research,unassigned 2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707460&form=6&db=m Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712449&form=6&db=m The potential and rationale for COX-2 inhibitors in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16714329&form=6&db=m Alpha-tocopheryl succinate, in contrast to alpha-tocopherol and alpha-tocopheryl acetate, inhibits prostaglandin E2 production in human lung epithelial cells. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16735371&form=6&db=m Association between cyclooxygenase-2 and matrix metalloproteinase-2 expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740761&form=6&db=m A phase I trial to determine the optimal biological dose of celecoxib when combined with erlotinib in advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16786043&form=6&db=m Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16798222&form=6&db=m Expression of nuclear factor-kappaB and its clinical significance in nonsmall-cell lung cancer. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820889&form=6&db=m PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872953&form=6&db=m Perioperative cyclooxygenase 2 inhibition to reduce tumor cell adhesion and metastatic potential of circulating tumor cells in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16912160&form=6&db=m LKB1/STK11 Suppresses Cyclooxygenase-2 Induction and Cellular Invasion through PEA3 in Lung Cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16914589&form=6&db=m Radiosensitivity enhancement by combined treatment of celecoxib and gefitinib on human lung cancer cells. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16969492&form=6&db=m Cyclooxygenase-2 inhibitor, nimesulide, improves radiation treatment against non-small cell lung cancer both in vitro and in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996907&form=6&db=m Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145853&form=6&db=m Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214885&form=6&db=m A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220375&form=6&db=m Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237818&form=6&db=m Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17250449&form=6&db=m Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17272310&form=6&db=m Increase of carcinogenic risk via enhancement of cyclooxygenase-2 expression and hydroxyestradiol accumulation in human lung cells as a result of interaction between BaP and 17-beta estradiol. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17329938&form=6&db=m Screening method for nonsteroidal antiinflammatory drugs based on the cyclooxygenase 2 pathway activated by serum-free stimulation in A549 cells. ongoing research,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17342322&form=6&db=m Failure of apoptosis and activation on NFkappaB by celecoxib and aspirin in lung cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17342342&form=6&db=m Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on lung cancer: roles of cyclooxygenase-2. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363603&form=6&db=m Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17381414&form=6&db=m Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17394509&form=6&db=m Correlation of cyclooxygenase-2 expression with hypoxia in non-small cell lung cancer. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404012&form=6&db=m DMNQ S-64 induces apoptosis via caspase activation and cyclooxygenase-2 inhibition in human nonsmall lung cancer cells. therapeutic application,unassigned 1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409801&form=6&db=m Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non-small cell lung cancer (NSCLC). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17412838&form=6&db=m Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17428102&form=6&db=m Cyclo-oxygenase-2 and its inhibition in cancer: is there a role? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17550984&form=6&db=m Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non small-cell lung cancer. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17575121&form=6&db=m Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17589567&form=6&db=m Reduced risk of human lung cancer by selective cyclooxygenase 2 (COX-2) blockade: results of a case control study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17600311&form=6&db=m EGFR Signaling Is Required for TGF-beta1 Mediated COX-2 Induction in Human Bronchial Epithelial Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17602268&form=6&db=m Characterization of the effects of cyclooxygenase-2 inhibition in the regulation of apoptosis in human small and non-small cell lung cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17664473&form=6&db=m Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non small-cell lung cancer. causal interaction,unassigned 2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17697767&form=6&db=m Ciglitazone mediates COX-2 dependent suppression of PGE2 in human non-small cell lung cancer cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17851225&form=6&db=m MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17927497&form=6&db=m Effects of Eicosapentaenoic and Docosahexaenoic n-3 Fatty Acids From Fish Oil and Preferential Cox-2 Inhibition on Systemic Syndromes in Patients With Advanced Lung Cancer. ongoing research,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055759&form=6&db=m Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18164040&form=6&db=m Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study. diagnostic usage,therapeutic application,unassigned 2,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18172786&form=6&db=m Selective COX-2 inhibitor celecoxib combined with EGFR-TKI ZD1839 on non-small cell lung cancer cell lines: in vitro toxicity and mechanism study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281656&form=6&db=m Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18304833&form=6&db=m Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18320840&form=6&db=m Role of cyclooxygenase-2 in tumor progression and immune regulation in lung cancer. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18348652&form=6&db=m NS-398 enhances the efficacy of gemcitabine against lung adenocarcinoma through up-regulation of p21WAF1 and p27KIP1 protein. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381949&form=6&db=m The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18453539&form=6&db=m COX-2/EGFR expression and survival among women with adenocarcinoma of the lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18499296&form=6&db=m A phase II study of carboplatin and paclitacel with meloxicam. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18671849&form=6&db=m Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18728211&form=6&db=m Serum free DNA and COX-2 mRNA expression in peripheral blood for lung cancer detection. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18769553&form=6&db=m The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18814280&form=6&db=m Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18978565&form=6&db=m Phase II study of docetaxel and celecoxib, a cyclooxygenase-2 inhibitor, in elderly or poor performance status (PS2) patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19031941&form=6&db=m Positive correlation between cyclooxygenase 2 and the expression of ABC transporters in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19157634&form=6&db=m The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19217709&form=6&db=m Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232171&form=6&db=m [The immunohistochemical expression of cyclooxygenase 2 is inversely associated with (18)F-FDG-PET SUV values in non-small-cell lung cancers. Initial results] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19235531&form=6&db=m Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19238334&form=6&db=m The expression of COX-2, hTERT, MDM2, LATS2 and S100A2 in different types of non-small cell lung cancer (NSCLC). ongoing research,unassigned 1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19266367&form=6&db=m Phase II study of celecoxib with cisplatin plus etoposide in extensive-stage small cell lung cancer. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19276291&form=6&db=m A phase II study of celecoxib in combination with paclitaxel, carboplatin, and radiotherapy for patients with inoperable stage IIIA/B non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280060&form=6&db=m Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19307990&form=6&db=m The immune tolerance of cancer is mediated by IDO that is inhibited by COX-2 inhibitors through regulatory T cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19360361&form=6&db=m Nimesulide, a selective COX-2 inhibitor, acts synergistically with ionizing radiation against A549 human lung cancer cells through the activation of caspase-8 and caspase-3. therapeutic application,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409031&form=6&db=m Targeting the eicosanoid pathway in non-small-cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19417670&form=6&db=m Chronic inflammation, chronic obstructive pulmonary disease, and lung cancer. causal interaction,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19423183&form=6&db=m Cigarette smoke and increased COX-2 and survivin levels in exhaled breath condensate of lung cancer patients: How hot is the link? causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19450893&form=6&db=m COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584262&form=6&db=m Cyclooxygenase-2 up-regulates ataxia telangiectasia and Rad3 related through extracellular signal-regulated kinase activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19703066&form=6&db=m Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19755515&form=6&db=m Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism. ongoing research,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19818596&form=6&db=m Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19918789&form=6&db=m Pachymic acid inhibits cell growth and modulates arachidonic acid metabolism in nonsmall cell lung cancer A549 cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19933775&form=6&db=m Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20016751&form=6&db=m Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20047843&form=6&db=m Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20132963&form=6&db=m Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145019&form=6&db=m Proanthocyanidins inhibit in vitro and in vivo growth of human non-small cell lung cancer cells by inhibiting the prostaglandin E(2) and prostaglandin E(2) receptors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20234320&form=6&db=m Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332326&form=6&db=m Cyclooxygenase-2 genetic variants are associated with survival in unresectable locally advanced non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353998&form=6&db=m Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530427&form=6&db=m Interaction of cyclooxygenase 2 genotype and smoking habit in Taiwanese lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592629&form=6&db=m Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20673501&form=6&db=m [Detection of EGFR and COX-2 expression by immunohistochemical method on a tissue microarray section in lung cancer and biological significance] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716424&form=6&db=m [The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731947&form=6&db=m [A phase II clinical trial of celecoxib combined with platinum-based chemotherapy in the treatment of patients with advanced NSCLC as first-line treatment.] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20883688&form=6&db=m Modulatory effect of hesperidin on benzo(a)pyrene induced experimental lung carcinogenesis with reference to COX-2, MMP-2 and MMP-9. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20922800&form=6&db=m Biomarker-based phase I dose-escalation, pharmacokinetic, and pharmacodynamic study of oral apricoxib in combination with erlotinib in advanced nonsmall cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21067863&form=6&db=m Combined treatment with the Cox-2 inhibitor niflumic acid and PPAR? ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21081043&form=6&db=m [Expression and significance of COX-2 and its transcription factors NFAT3 and c-Jun in non-small cell lung cancer]. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21114937&form=6&db=m [Prognostic value of survivin and cyclooxygenase-2 expression in non-small cell lung cancer: a tissue microarray analysis.] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118643&form=6&db=m [Suppression of COX-2 protein to cell apoptosis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118647&form=6&db=m [Correlation of time-density curve of CT enhancement with angiogenesis in lung cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21150337&form=6&db=m LKB1/PEA3/?Np63 pathway regulates PTGS-2 (COX-2) transcription in lung cancer cells upon cigarette smoke exposure. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21189177&form=6&db=m [Expressions of cyclooxygenase-2 and vascular endothelial growth factor in human lung cancer tissue.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21198273&form=6&db=m Association of the 8473T>C Cyclooxygenase-2 (COX-2) Gene Polymorphism with Lung Cancer Risk in Asians. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205525&form=6&db=m [Effects of cyclooxygenase-2 antisense vector on proliferation and sensitivity to cisplatin of H1299 cells.] causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215004&form=6&db=m [Expression of COX-2 and its prognostic significance in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219643&form=6&db=m Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21232215&form=6&db=m [Effect of cyclooxygenase-2 inhibitor, nimesulide, combined with cisplatin on lung cancer.] ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21251407&form=6&db=m [Study of COX-2 expression and angiogenesis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21252117&form=6&db=m Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers. ongoing research,unassigned 2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21272377&form=6&db=m Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21303331&form=6&db=m Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21319320&form=6&db=m Cyclooxygenase-2 expression in lung cancer cells evaluated by immunocytochemistry. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21385353&form=6&db=m EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443775&form=6&db=m Correction: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21461558&form=6&db=m Tubeimoside-1 inhibits proliferation and induces apoptosis by increasing the Bax to Bcl-2 ratio and decreasing COX-2 expression in lung cancer A549 cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21472198&form=6&db=m Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21550559&form=6&db=m Phase I/II trial of a COX-2 inhibitor with limited field radiation for intermediate prognosis patients who have locally advanced non-small-cell lung cancer: radiation therapy oncology group 0213. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21565487&form=6&db=m Effect of celecoxib on survival in patients with advanced non-small cell lung cancer: a double blind randomised clinical phase III trial (CYCLUS study) by the Swedish Lung Cancer Study Group. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21565488&form=6&db=m IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21572400&form=6&db=m Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21600223&form=6&db=m COX-2 expression is correlated with VEGF-C, lymphangiogenesis and lymph node metastasis in human cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21605904&form=6&db=m Histamine regulates cyclooxygenase 2 gene activation through Orai1-mediated NF?B activation in lung cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21678473&form=6&db=m Overexpression of cyclooxygenase-2 in NCI-H292 human alveolar epithelial carcinoma cells: Roles of p38 MAPK, ERK-1/2, and PI3K/PKB signaling proteins. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21733822&form=6&db=m Lung cancer chemoprevention with celecoxib in former smokers. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763448&form=6&db=m Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21768098&form=6&db=m NF-{kappa}B mediates a protective response in cancer cells treated with inhibitors of fatty acid synthase. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21798652&form=6&db=m Cyclooxigenase-2 Levels are Increased in the Lung Tissue and Bronchial Tumors of Patients with Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21840302&form=6&db=m Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: A novel cyclooxygenase-inhibition-independent effect. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21882257&form=6&db=m Silibinin modulates TNF-? and IFN-? mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21936449&form=6&db=m COX-2 inhibitor, celecoxib, may prevent lung cancer. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21990410&form=6&db=m Randomized, placebo-controlled phase III study of docetaxel plus carboplatin with celecoxib and cyclooxygenase-2 expression as a biomarker for patients with advanced non-small-cell lung cancer: the NVALT-4 study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22024643&form=6&db=m Elevation of Prostaglandin E2 in Lung Cancer Patients with Digital Clubbing. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22093832&form=6&db=m Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-?-treated A549 cells. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22121107&form=6&db=m Combined histone deacetylase and cyclooxygenase inhibition achieves enhanced antiangiogenic effects in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22292629&form=6&db=m Lack of association of the cyclooxygenase 8473 T>C polymorphism with lung cancer: evidence from 9841 subjects. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22344367&form=6&db=m Inhibition of cyclooxygenase-2 by tetramethylpyrazine and its effects on A549 cell invasion and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22394008&form=6&db=m Association of COX-2 8473T>C Gene Polymorphism with Lung Cancer Risk. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22411738&form=6&db=m Chemopreventive effects of NSAIDs as inhibitors of cyclooxygenase-2 and inducers of apoptosis in experimental lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22464751&form=6&db=m SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22473168&form=6&db=m Cyclooxygenase-2 (COX-2) as a predictive marker for the use of COX-2 inhibitors in advanced non-small-cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22480996&form=6&db=m Aspirin and non-aspirin non-steroidal anti-inflammatory drug use and risk of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22482414&form=6&db=m [Expression and clinical significance of CD3, CD4 and COX-2 in non-small cell lung cancer]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22502692&form=6&db=m Cyclooxygenase-2 expression is not a marker of poor survival in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22613332&form=6&db=m [Effects of tea polyphenols on the expression of NF-?B, COX-2 and survivin in Lewis lung carcinoma xenografts in C57BL/6 mice]. ongoing research,unassigned 2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22649768&form=6&db=m Phase I study of celecoxib with concurrent irinotecan, Cisplatin, and radiation therapy for patients with unresectable locally advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22667343&form=6&db=m Immunohistochemical study of cyclooxygenase-2 in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22672748&form=6&db=m Mitigation and Treatment of Radiation-Induced Thoracic Injury With a Cyclooxygenase-2 Inhibitor, Celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22678114&form=6&db=m Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib. ongoing research,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22681911&form=6&db=m Angiostatic role of the selective cyclooxygenase-2 inhibitor etoricoxib (MK0663) in experimental lung cancer. therapeutic application,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22696230&form=6&db=m Galectin-1 Promotes Lung Cancer Progression and Chemoresistance by Upregulating p38 MAPK, ERK, and Cyclooxygenase-2. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22752388&form=6&db=m Downregulation of NF-?B and PCNA in the regulatory pathways of apoptosis by cyclooxygenase-2 inhibitors in experimental lung cancer. therapeutic application,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22761909&form=6&db=m Synergistic association of PTGS2 and CYP2E1 genetic polymorphisms with lung cancer risk in northeastern Chinese. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22803374&form=6&db=m [Effect of NF-kappaB on inhibition of non-small cell lung cancer cell cyclooxygenase-2 by brucine]. ongoing research,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22814015&form=6&db=m Upregulation of intrinsic apoptotic pathway in NSAIDs mediated chemoprevention of experimental lung carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22991065&form=6&db=m Role of cytokines in experimentally induced lung cancer and chemoprevention by COX-2 selective inhibitor, etoricoxib. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23036202&form=6&db=m Green tea inhibits cycolooxygenase-2 in non-small cell lung cancer cells through the induction of Annexin-1. ongoing research,unassigned 2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23065687&form=6&db=m Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23172668&form=6&db=m Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23180004&form=6&db=m Immunohistochemical molecular expression profile of metastatic brain tumor for potent personalized medicine. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23220503&form=6&db=m COX-2 and PPAR-? confer cannabidiol-induced apoptosis of human lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23291066&form=6&db=m [Inhibitory effect of nimesulide and oxaliplatin on tumor growth and lymphatic metastasis of transplanted human lung cancer in nude mice]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23372950&form=6&db=m Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384501&form=6&db=m Cox-2 in non-small cell lung cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,3
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23443799&form=6&db=m A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy. therapeutic application,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23601296&form=6&db=m [Mechanisms of EGF regulation of COX-2 through the STAT5 signaling pathway in human lung adenocarcinoma A549 cells]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23620771&form=6&db=m The association between COX-2 polymorphisms and hematologic toxicity in patients with advanced non-small-cell lung cancer treated with platinum-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23943857&form=6&db=m INDUCTION BUT NOT INHIBITION OF COX-2 CONFERS HUMAN LUNG CANCER CELL APOPTOSIS BY CELECOXIB. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098479&form=6&db=m TGF-?1 Downregulates COX-2 Expression Leading to Decrease of PGE2 Production in Human Lung Cancer A549 Cells, Which Is Involved in Fibrotic Response to TGF-?1. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24246081&form=6&db=m [Cyclooxygenase 2 genetic variant interacting with tobacco smoking and the risk of lung cancer]. diagnostic usage,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337484&form=6&db=m Butein induces cell apoptosis and inhibition of cyclooxygenase?2 expression in A549 lung cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24344016&form=6&db=m Lentivirus-mediated shRNA interference targeting cyclooxygenase-2 inhibits growth of human non-small cell lung cancer. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24472607&form=6&db=m The NF-?B family member RelB regulates microRNA miR-146a to suppress cigarette smoke-induced COX-2 protein expression in lung fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24528083&form=6&db=m Simultaneous blockage of epidermal growth factor receptor and cyclooxygenase-2 in a human xenotransplanted lung cancer model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24549815&form=6&db=m Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24735610&form=6&db=m The rigid steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a dissociated glucocorticoid receptor modulator potentially useful as a novel coadjuvant in breast cancer chemotherapy. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24736085&form=6&db=m A randomized, placebo-controlled, multicenter, biomarker-selected, phase 2 study of apricoxib in combination with erlotinib in patients with advanced non-small-cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24909729&form=6&db=m Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25047043&form=6&db=m Regulation of COX-2 expression by miR-146a in lung cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054040&form=6&db=m Cyclooxygenase-2 inhibitors for non-small-cell lung cancer: A phase II trial and literature review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25113252&form=6&db=m COX-2 overexpression and -8473 T/C polymorphism in 3' UTR in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131817&form=6&db=m Prognostic value of cyclooxygenase-2 gene polymorphisms in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25137041&form=6&db=m Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25175164&form=6&db=m Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKK?/NF-?B signaling pathway in lung cancer cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202373&form=6&db=m Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25246059&form=6&db=m Inhibitory effects of scutellarein on proliferation of human lung cancer A549 cells through ERK and NF?B mediated by the EGFR pathway. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25338928&form=6&db=m Cyclooxygenase-2 genetic variants influence intratumoral infiltration of Foxp3-positive regulatory T cells in non-small cell lung cancer. diagnostic usage,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25449785&form=6&db=m Prognostic impact of COX-2 in non-small cell lung cancer: a comprehensive compartment-specific evaluation of tumor and stromal cell expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25452446&form=6&db=m Randomized, double-blind, placebo-controlled, multicenter phase ii study of the efficacy and safety of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected non-small-cell lung cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25465874&form=6&db=m Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25544576&form=6&db=m TGF-? Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells. ongoing research,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25797267&form=6&db=m Ku80 cooperates with CBP to promote COX-2 expression and tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25817787&form=6&db=m USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25888998&form=6&db=m Cyclooxygenase-2 expression is a prognostic biomarker for non-small cell lung cancer patients treated with adjuvant platinum-based chemotherapy. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25975224&form=6&db=m The VEGFR2, COX-2 and MMP-2 polymorphisms are associated with clinical outcome of patients with inoperable non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26011146&form=6&db=m Inhibition of 11?-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26033783&form=6&db=m Cyclooxygenase 2 inhibition in patients with non-small cell lung cancer: Is this still a valid target for therapy? diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26033830&form=6&db=m Randomized phase 2 trial of erlotinib in combination with high-dose celecoxib or placebo in patients with advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26045835&form=6&db=m Association between COX-2 polymorphisms and non-small cell lung cancer susceptibility. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26202355&form=6&db=m rs2910164 Polymorphism Confers a Decreased Risk for Pulmonary Hypertension by Compromising the Processing of microRNA-146a. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26253302&form=6&db=m Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway. ongoing research,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26430963&form=6&db=m The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26452035&form=6&db=m Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464643&form=6&db=m Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 Level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26523208&form=6&db=m Combination Treatment with Apricoxib and IL-27 Enhances Inhibition of Epithelial-Mesenchymal Transition in Human Lung Cancer Cells through a STAT1 Dominant Pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26548623&form=6&db=m Cyclooxygenase-2 inhibitors in lung cancer treatment: Bench to bed. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26557918&form=6&db=m Micro ribonucleic acid (RNA)-101 inhibits cell proliferation and invasion of lung cancer by regulating cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26597177&form=6&db=m Anti-tumor enhancement of Fei-Liu-Ping ointment in combination with celecoxib via cyclooxygenase-2-mediated lung metastatic inflammatory microenvironment in Lewis lung carcinoma xenograft mouse model. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26624903&form=6&db=m Association Between COX-2 Polymorphisms and Lung Cancer Risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629442&form=6&db=m Revisiting the role of COX-2 inhibitor for non-small cell lung cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26744864&form=6&db=m MiR-26b suppresses tumor cell proliferation, migration and invasion by directly targeting COX-2 in lung cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26774881&form=6&db=m hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26777972&form=6&db=m Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy. diagnostic usage,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26861394&form=6&db=m Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26863638&form=6&db=m Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR?-dependent pathway. ongoing research,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26969386&form=6&db=m Methyl syringate, a TRPA1 agonist represses hypoxia-induced cyclooxygenase-2 in lung cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27007231&form=6&db=m Clinical Profile of Cyclooxygenase-2 Inhibitors in Treating Non-Small Cell Lung Cancer: A Meta-Analysis of Nine Randomized Clinical Trials. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27020529&form=6&db=m Nebulizable colloidal nanoparticles co-encapsulating a COX-2 inhibitor and a herbal compound for treatment of lung cancer. therapeutic application,unassigned 4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27217781&form=6&db=m HER2 induces cell proliferation and invasion of non-small-cell lung cancer by upregulating COX-2 expression via MEK/ERK signaling pathway. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27268917&form=6&db=m Knockdown of 14-kDa phosphohistidine phosphatase expression suppresses lung cancer cell growth in vivo possibly through inhibition of NF-?B signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27450326&form=6&db=m Cleavage and polyadenylation specific factor 4 targets NF-?B/cyclooxygenase-2 signaling to promote lung cancer growth and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27642319&form=6&db=m Celecoxib Treatment Alters p53 and MDM2 Expression via COX-2 Crosstalk in A549 Cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27654511&form=6&db=m Cyclooxygenase-2 induced ?1-integrin expression in NSCLC and promoted cell invasion via the EP1/MAPK/E2F-1/FoxC2 signal pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27696404&form=6&db=m Retraction. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27765529&form=6&db=m Identification of key genes involved in nasopharyngeal carcinoma. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895738&form=6&db=m Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28150906&form=6&db=m Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28173828&form=6&db=m Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway. causal interaction,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28282799&form=6&db=m Celecoxib-erlotinib combination treatment enhances radiosensitivity in A549 human lung cancer cell. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28285696&form=6&db=m Effects of aspirin on small-cell lung cancer mortality and metastatic presentation. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28413655&form=6&db=m Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489511&form=6&db=m Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28709031&form=6&db=m Bisphenol A induces COX-2 through the mitogen-activated protein kinase pathway and is associated with levels of inflammation-related markers in elderly populations. causal interaction,unassigned 1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789387&form=6&db=m Urinary levels of prostaglandin E2 are positively correlated with intratumoral infiltration of Foxp3(+) regulatory T cells in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28837884&form=6&db=m Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/?-catenin signalling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28972958&form=6&db=m Immunoexpression analysis of selected JAK/STAT pathway molecules in patients with non- small-cell lung cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28979299&form=6&db=m Physicochemical, Stress Degradation Evaluation and Pharmacokinetic Study of AZGH102, a New Synthesized COX2 Inhibitors after I.V. and Oral Administration in Male and Female Rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29025423&form=6&db=m Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29113232&form=6&db=m Inhibition of cyclooxygenase-2 sensitizes lung cancer cells to radiation-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29140138&form=6&db=m COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29236213&form=6&db=m Structural Probing, Screening and Structure-Based Drug Repositioning Insights into the Identification of Potential Cox-2 Inhibitors from Selective Coxibs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29345286&form=6&db=m Cyclooxygenase-2 expression is induced by celecoxib treatment in lung cancer cells and is transferred to neighbor cells via exosomes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29354301&form=6&db=m Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress. ongoing research,unassigned 2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408308&form=6&db=m Inflammatory Gene Polymorphisms in Lung Cancer Susceptibility. ongoing research,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29440919&form=6&db=m Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29484424&form=6&db=m Knockdown of end-binding protein 1 induces apoptosis in radioresistant A549 lung cancer cells via p38 kinase-dependent COX-2 upregulation. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29922432&form=6&db=m Cyclooxygenase inhibitors combined with deuterium-enriched water augment cytotoxicity in A549 lung cancer cell line via activation of apoptosis and MAPK pathways. therapeutic application,unassigned 3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928483&form=6&db=m miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29982425&form=6&db=m Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30114468&form=6&db=m Amaryllidaceae alkaloids from Crinum latifolium with cytotoxic, antimicrobial, antioxidant, and anti-inflammatory activities. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30122902&form=6&db=m Systematic review and meta-analysis of the benefit of celecoxib in treating advanced non-small-cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127893&form=6&db=m Decreased expression level and DNA-binding activity of specificity protein 1 via cyclooxygenase-2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation-resistant lung cancer cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30170377&form=6&db=m COX-2 rs5275 and rs689466 polymorphism and risk of lung cancer: A PRISMA-compliant meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30365050&form=6&db=m Suppression of cyclooxygenase 2 increases chemosensitivity to sesamin through the Akt?PI3K signaling pathway in lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30591531&form=6&db=m Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930224&form=6&db=m Inhibition of PSMD4 blocks the tumorigenesis of hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31109107&form=6&db=m Reconsidering the Role of Cyclooxygenase Inhibition in the Chemotherapeutic Value of NO-Releasing Aspirins for Lung Cancer. therapeutic application,unassigned 2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31115011&form=6&db=m COX-2 potentiates cisplatin resistance of non-small cell lung cancer cells by promoting EMT in an AKT signaling pathway-dependent manner. therapeutic application,unassigned 1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186812&form=6&db=m Erratum: Inhibition of cyclooxygenase-2 sensitizes lung cancer cells to radiation-induced apoptosis. therapeutic application,unassigned 2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31231223&form=6&db=m Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31440159&form=6&db=m The Role of Prostaglandin-Endoperoxide Synthase-2 in Chemoresistance of Non-Small Cell Lung Cancer. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31613929&form=6&db=m Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31665187&form=6&db=m Correction: Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression. unassigned -
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31791289&form=6&db=m PPAR? ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31851351&form=6&db=m Effect of Concurrent Chemoradiation With Celecoxib vs Concurrent Chemoradiation Alone on Survival Among Patients With Non-Small Cell Lung Cancer With and Without Cyclooxygenase 2 Genetic Variants: A Phase 2 Randomized Clinical Trial. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934287&form=6&db=m BPTF cooperates with p50 NF-?B to promote COX-2 expression and tumor cell growth in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32284763&form=6&db=m Cyclooxygenase-2 mediates gefitinib resistance in non-small cell lung cancer through the EGFR/PI3K/AKT axis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32489686&form=6&db=m Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell lung cancer cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32521872&form=6&db=m Effect of molecular targeted therapy combined with radiotherapy on the expression and prognostic value of COX-2 and VEGF in bone metastasis of lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655834&form=6&db=m miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32904445&form=6&db=m Inhibition of PI3K-AKT Signaling Blocks PGE2-Induced COX-2 Expression in Lung Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014157&form=6&db=m Celecoxib upregulates ULBP-1 expression in lung cancer cells via the JNK/PI3K signaling pathway and increases susceptibility to natural killer cell cytotoxicity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33299414&form=6&db=m Bellidifolin Inhibits Proliferation of A549 Cells by Regulating STAT3/COX-2 Expression and Protein Activity. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33437163&form=6&db=m Korean Red Ginseng suppresses bisphenol A-induced expression of cyclooxygenase-2 and cellular migration of A549 human lung cancer cell through inhibition of reactive oxygen species. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33473256&form=6&db=m miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33553396&form=6&db=m Clinical benefit of COX-2 inhibitors in the adjuvant chemotherapy of advanced non-small cell lung cancer: A systematic review and meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33557033&form=6&db=m 2D Nanomaterial, Ti3C2 MXene-Based Sensor to Guide Lung Cancer Therapy and Management. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33559253&form=6&db=m Effect of cyclooxygenase inhibitor use on immunotherapy efficacy in non-small cell lung cancer. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102280&form=6&db=m Iminodibenzyl redirected cyclooxygenase-2 catalyzed dihomo-?-linolenic acid peroxidation pattern in lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=79920&form=6&db=m Renal prostaglandins in systemic lupus erythematosus. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12139371&form=6&db=m Celecoxib for systemic lupus erythematosus: case series and literature review of the use of NSAIDs in SLE. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16871410&form=6&db=m Cyclooxygenase-2 polymorphisms and risk of systemic lupus erythematosus in Koreans. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17761345&form=6&db=m Apoptosis of murine lupus T cells induced by the selective cyclooxygenase-2 inhibitor celecoxib: molecular mechanisms and therapeutic potential. causal interaction,unassigned 1,0
1.14.99.1 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18050205&form=6&db=m Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Lupus Erythematosus, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056333&form=6&db=m [Recommendation for the prevention and treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal ulcers and its complications]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3455932&form=6&db=m Increased renal thromboxane production in murine lupus nephritis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9644630&form=6&db=m Upregulation of renal and systemic cyclooxygenase-2 in patients with active lupus nephritis. ongoing research,unassigned 4,0
1.14.99.1 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9820447&form=6&db=m Eicosanoid synthesis in peripheral blood monocytes: a marker of disease activity in lupus nephritis. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135071&form=6&db=m Hyaluronan-induced cyclooxygenase-2 expression promotes thromboxane A2 production by renal cells. ongoing research,unassigned 4,0
1.14.99.1 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11473648&form=6&db=m Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18459455&form=6&db=m Analysis of renal immunoexpression of cyclooxygenase-1 and cyclooxygenase-2 in lupus and nonlupus membranous glomerulopathy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20924284&form=6&db=m Selective Cyclooxygenase-2 Inhibitor Suppresses Renal Thromboxane Production but Not Proliferative Lesions in the MRL/lpr Murine Model of Lupus Nephritis. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Lupus Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30025388&form=6&db=m Activation of Cyclooxygenase-2 by ATF4 During Endoplasmic Reticulum Stress Regulates Kidney Podocyte Autophagy Induced by Lupus Nephritis. unassigned -
1.14.99.1 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12423770&form=6&db=m Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438879&form=6&db=m Arthritis develops but fails to resolve during inhibition of cyclooxygenase 2 in a murine model of Lyme disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19487688&form=6&db=m Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis. causal interaction,unassigned 2,0
1.14.99.1 Lyme Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843949&form=6&db=m Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731479&form=6&db=m Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398082&form=6&db=m Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10404093&form=6&db=m Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10684704&form=6&db=m High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11176123&form=6&db=m Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11326316&form=6&db=m Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11443626&form=6&db=m Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786771&form=6&db=m Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819707&form=6&db=m Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection, histological types and staging. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12037025&form=6&db=m Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066205&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086404&form=6&db=m Increased expression of COX-2 in the development of human lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196922&form=6&db=m Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434411&form=6&db=m Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452062&form=6&db=m [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12532441&form=6&db=m Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622426&form=6&db=m Expression of cyclooxygenase-2 protein in colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631609&form=6&db=m Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12667327&form=6&db=m [Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679908&form=6&db=m Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686777&form=6&db=m Expression of COX-2 in stomach cancers and its relation to their biological features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767510&form=6&db=m Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821346&form=6&db=m Expression of cyclooxygenase-1 and -2 associated with expression of VEGF in primary cervical cancer and at metastatic lymph nodes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839690&form=6&db=m [Relation between COX-2 protein expression and biologic behavior of ovarian carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12854133&form=6&db=m Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883661&form=6&db=m Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883688&form=6&db=m Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957358&form=6&db=m Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534699&form=6&db=m Cyclooxygenase-2 expression in lymph node metastasis of cervical and vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14616542&form=6&db=m Cyclooxygenase-2 and gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681319&form=6&db=m Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688483&form=6&db=m Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716842&form=6&db=m Expression of COX-2 proteins in gastric mucosal lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14989896&form=6&db=m [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15023244&form=6&db=m Prognostic impact of cyclooxygenase-2 in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075004&form=6&db=m Expression of cyclooxygenase-1 and -2 and clinicopathologic features of colorectal cancer in northern Thailand. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151619&form=6&db=m Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179621&form=6&db=m The role of COX-2 inhibition in breast cancer treatment and prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222024&form=6&db=m Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15230726&form=6&db=m Cyclo-oxygenase-2 expression in esophageal adenocarcinoma as a determinant of clinical outcome following esophagectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272284&form=6&db=m COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15342458&form=6&db=m Cyclooxygenase-2 and p53 expressions in endometrial cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15461861&form=6&db=m Cyclooxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501972&form=6&db=m Concomitant overexpression of cyclooxygenase-2 in HER-2-positive on Smad4-reduced human gastric carcinomas is associated with a poor patient outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623626&form=6&db=m Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15634545&form=6&db=m [The role of cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of gastric cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15704107&form=6&db=m Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754389&form=6&db=m Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754411&form=6&db=m Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947945&form=6&db=m Cyclooxygenase-2 in normal, hyperplastic and neoplastic follicular cells of the human thyroid gland. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15968728&form=6&db=m Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054423&form=6&db=m Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111807&form=6&db=m Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167259&form=6&db=m [Relationship between cyclooxygenase- 2 expression and angiogenesis in patients with gastric cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167260&form=6&db=m [COX- 2 expression in gastric cancer and its relationship with lymphangiogenesis and lymph node metastasis] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16199309&form=6&db=m Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16246405&form=6&db=m Prevalence and prognostic significance of COX-2 expression in stage IB cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16260857&form=6&db=m Overexpression of cyclooxygenase-2 in gastric cancer correlates with the high abundance of vascular endothelial growth factor-C and lymphatic metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314343&form=6&db=m Expression of cyclooxygenase-2 and matrix metalloproteinase-9 in gastric carcinoma and its correlation with angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16324362&form=6&db=m [Correlation between Stat3 signal transduction pathway and expression of cyclooxygenase-2 in colorectal cancer cells] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474989&form=6&db=m Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16483484&form=6&db=m [Expression of vascular endothelial growth factor C and cyclooxygenase-2 in non-small-cell lung carcinoma and their clinical significance.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489098&form=6&db=m The Cyclooxygenase-2 (PTGS2) 8473T>C Polymorphism is Associated with Breast Cancer Risk. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16494037&form=6&db=m [The expressiong of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507389&form=6&db=m Aberrant methylation of cyclooxygenase-2 in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507394&form=6&db=m Cyclooxygenase-2 expression is associated with VEGF-C and lymph node metastases in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16720448&form=6&db=m Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900533&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16938519&form=6&db=m The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984531&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996907&form=6&db=m Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030351&form=6&db=m COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062337&form=6&db=m [Association of abnormal cyclooxygenase-2 gene expression with colorectal carcinoma metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17118848&form=6&db=m Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17147116&form=6&db=m [Flow cytometric quantitative analysis of multiple tumor suppressor gene 1 (MTS1) and cyclooxygenase-2 (COX-2) gene expressions in invasive breast cancers and their clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17278192&form=6&db=m Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291249&form=6&db=m Cyclooxygenase-2 expression in cervical intraepithelial neoplasia III and squamous cell cervical carcinoma, and its correlation with clinicopathologic variables. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403293&form=6&db=m [Evaluation of cyclooxygenase-2 in the prediction of liver metastasis of colorectal carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413988&form=6&db=m Identification of potential prognostic markers for vulvar cancer using immunohistochemical staining of tissue microarrays. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17427971&form=6&db=m Prognostic significance of cyclooxygenase-2 and DNA topoisomerase IIalpha expression in oral carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17608853&form=6&db=m Involvement of cyclooxygenase-2 and vascular endothelial growth factor in vascularization and lymph node metastasis of colorectal cancers with submucosal invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17672932&form=6&db=m [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17721268&form=6&db=m COX-2 expression in invasive breast cancer: correlation with prognostic parameters and outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17762961&form=6&db=m 5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956162&form=6&db=m Clinical, histopathological, and molecular characteristics of papillary thyroid microcarcinoma. diagnostic usage,unassigned 3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17968676&form=6&db=m PTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974958&form=6&db=m Inhibition of Cyclooxygenase-2 Suppresses Lymph Node Metastasis via Reduction of Lymphangiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18068001&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor-C correlates with lymphangiogenesis and lymphatic invasion in human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18069634&form=6&db=m [Expression of COX-2 and MMP-9 in cervical carcinoma and their clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159174&form=6&db=m [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174234&form=6&db=m Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18181047&form=6&db=m Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18190720&form=6&db=m Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18250037&form=6&db=m [Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288396&form=6&db=m Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18319253&form=6&db=m Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18353210&form=6&db=m [The relationship between lymphatic metastasis and serum vascular endothelial growth factor C and cyclooxygenase 2 expression in breast cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18594470&form=6&db=m Cyclooxygenase-2 expression in primary and metastatic Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18950008&form=6&db=m [Expressions of COX-2 and MMP-2 in nasopharyngeal carcinoma and the their relationship with lymph node metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18977022&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the uterine cervix is associated with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138835&form=6&db=m A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280060&form=6&db=m Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19300368&form=6&db=m Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in Oral Squamous Cell Carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19391129&form=6&db=m COX-2 is induced by HGF stimulation in Met-positive thyroid papillary carcinoma cells and is involved in tumour invasiveness. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509584&form=6&db=m Assessment of promising protein markers for vulva cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19608016&form=6&db=m Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19685508&form=6&db=m Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via VEGF-C. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19730383&form=6&db=m The relationship between HPV16 and expression of cyclooxygenase-2, P53 and their prognostic roles in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19751908&form=6&db=m Predictive value of cyclooxygenase 2 and Bcl-2 for cervical lymph node metastasis in mucoepidermoid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19816074&form=6&db=m The relationship between cyclooxygenase-2, CD44v6, and nm23H1 in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19821125&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19939424&form=6&db=m The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956498&form=6&db=m Expression of Cyclooxygenase-2 in Human Breast Cancer: Relationship with HER-2/neu and other Clinicopathological Prognostic Factors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20019776&form=6&db=m [Expression and function of cyclooxygenase-2 in endometrial carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20021866&form=6&db=m [Expression of COX-2 and VEGF and their correlation with angiogenesis in human clear cell renal cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20132963&form=6&db=m Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192574&form=6&db=m Cyclooxygenase-2 Expression in Cervical Squamous Cell Carcinoma: the Significance of Expression in Neoplastic Cells within the Lymphovascular Space. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20213098&form=6&db=m Circulating cycloxygenase-2 in patients with tobacco-related intraoral squamous cell carcinoma and evaluation of its peptide inhibitors as potential antitumor agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428812&form=6&db=m Potential of molecular targeted therapy of HER-2 and Cox-2 for invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20608938&form=6&db=m Relationship between cyclooxygenase-2 and human epidermal growth factor receptor 2 in vascular endothelial growth factor C up-regulation and lymphangiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635052&form=6&db=m [Expression of NF-kappaB and COX-2 in tongue squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20673501&form=6&db=m [Detection of EGFR and COX-2 expression by immunohistochemical method on a tissue microarray section in lung cancer and biological significance] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20830783&form=6&db=m COX-2-mediated regulation of VEGF-C in association with lymphangiogenesis and lymph node metastasis in lung cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878581&form=6&db=m [Correlation of cyclooxygenase 2 expression with microlymphatic density and its clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960565&form=6&db=m Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21114937&form=6&db=m [Prognostic value of survivin and cyclooxygenase-2 expression in non-small cell lung cancer: a tissue microarray analysis.] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118643&form=6&db=m [Suppression of COX-2 protein to cell apoptosis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118647&form=6&db=m [Correlation of time-density curve of CT enhancement with angiogenesis in lung cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215004&form=6&db=m [Expression of COX-2 and its prognostic significance in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426663&form=6&db=m [The Expression and Clinical Significance of HIF-1?, COX-2 and E-cadherin in Patients with Lung Adenocarcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443099&form=6&db=m Expression of COX-2, survivin in regional lymph node metastases of gastric carcinoma and the correlation with prognosis. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479487&form=6&db=m Cyclooxygenase-2 expression in invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21600223&form=6&db=m COX-2 expression is correlated with VEGF-C, lymphangiogenesis and lymph node metastasis in human cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371637&form=6&db=m Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22372762&form=6&db=m Prognostic value of apoptotic markers in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22389271&form=6&db=m Correlation between Spiral CT Preoperative Staging of Pancreatic Cancer and PTEN and COX-2 Expression. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735610&form=6&db=m Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22751903&form=6&db=m Antitumor and anti-metastatic effects of cyclooxygenase-2 inhibition by celecoxib on human colorectal carcinoma xenografts in nude mouse rectum. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23011604&form=6&db=m Protein predictive signatures for lymph node metastasis of gastric cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23052170&form=6&db=m Heterogeneity of COX-2 and multidrug resistance between primary tumors and regional lymph node metastases of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23260331&form=6&db=m Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23291066&form=6&db=m [Inhibitory effect of nimesulide and oxaliplatin on tumor growth and lymphatic metastasis of transplanted human lung cancer in nude mice]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23375645&form=6&db=m Aberrant expression of ?-catenin and E-cadherin is correlated with poor prognosis of nasopharyngeal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520664&form=6&db=m Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675067&form=6&db=m Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23809761&form=6&db=m Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019861&form=6&db=m Expression of COX-2, CD44v6 and CD147 and Relationship with Invasion and Lymph Node Metastasis in Hypopharyngeal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24060154&form=6&db=m Concurrent Expression of Cyclo-oxygenase-2 and Epidermal Growth Factor Receptor in Canine Malignant Mammary Tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24259966&form=6&db=m Role of cyclooxygenase-2 in gastric cancer development and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24560404&form=6&db=m Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-c and lymph node metastasis in human oral tongue cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24669166&form=6&db=m Role of Cyclooxygenase 2 (COX-2) in Prognosis of Breast Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24704993&form=6&db=m MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24787377&form=6&db=m Inflammation induced by human papillomavirus in cervical cancer and its implication in prevention. causal interaction,unassigned 4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922641&form=6&db=m Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24992958&form=6&db=m Cyclooxygenase-2 inhibition as a strategy for treating gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054056&form=6&db=m Cyclooxygenase-2 expression in non-metastatic triple-negative breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25060857&form=6&db=m Overexpression of Wild-Type p53-Induced Phosphatase 1 Confers Poor Prognosis of Patients with Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25142993&form=6&db=m [Relationship between cyclooxygenase-2 in nasopharyngeal carcinoma and cervical lymph node metastasis]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337538&form=6&db=m Cyclooxygenase-1 and -2: molecular targets for cervical neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25888998&form=6&db=m Cyclooxygenase-2 expression is a prognostic biomarker for non-small cell lung cancer patients treated with adjuvant platinum-based chemotherapy. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26101475&form=6&db=m Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26323923&form=6&db=m Expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in Chinese patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26423666&form=6&db=m Expression and Significance of COX-2 and Ki-67 in Hepatolithiasis with Bile Duct Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498465&form=6&db=m Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622766&form=6&db=m Cyclooxygenase-2 gene polymorphisms and the risk of colorectal cancer: A population-based study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26791964&form=6&db=m Clinical relevance of cyclo-oxygenase 2 and peroxisome proliferator activated receptor ? in eyelid sebaceous gland carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870269&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and interleukin-32 in primary gastric B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27198692&form=6&db=m Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27234549&form=6&db=m HER-2, EGFR, Cox-2 and Ki67 expression in lymph node metastasis of canine mammary carcinomas: Association with clinical-pathological parameters and overall survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323811&form=6&db=m Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27391144&form=6&db=m Intratumoral expression of cyclooxygenase-2 (COX-2) is a negative prognostic marker for patients with cutaneous melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27457107&form=6&db=m Prognostic significance of expression of cysteine-rich 61 and cyclooxygenase-2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27999206&form=6&db=m Clinicopathological and prognostic significance of COX-2 immunohistochemical expression in breast cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056899&form=6&db=m PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28188432&form=6&db=m Correlations of IGF-1R and COX-2 Expressions with Ras and BRAF Genetic Mutations, Clinicopathological Features and Prognosis of Colorectal Cancer Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28231855&form=6&db=m COX-2 expression positively correlates with PD-L1 expression in human melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272681&form=6&db=m Correlation of COX- 2 Expression in Colorectal Carcinoma with Clinicopathological Features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28301518&form=6&db=m Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474124&form=6&db=m Expressions and clinical significance of COX-2, VEGF-C, and EFGR in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521457&form=6&db=m Expression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28652771&form=6&db=m The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28740192&form=6&db=m Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927045&form=6&db=m Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767863&form=6&db=m Influence of VEGF, COX-2, and MMP-9 expression on the molybdenum-targeted X-ray in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858743&form=6&db=m Roles of prostaglandins in tumor-associated lymphangiogenesis with special reference to breast cancer. ongoing research,unassigned 4,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30079321&form=6&db=m Quantitative analysis of COX-2 promoter methylation in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087034&form=6&db=m The association between COX-2 gene rs5275 polymorphism and Nasopharyngeal carcinoma risk. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30106414&form=6&db=m Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients. An experience from Western Saudi Arabia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435431&form=6&db=m Evaluation of VEGF expression correlates with COX-2 expression in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903705&form=6&db=m Prognostic and Clinical Significance of Cyclooxygenase-2 Overexpression in Endometrial Cancer: A Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257723&form=6&db=m Metformin suppresses breast cancer growth via inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Lymphedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21577211&form=6&db=m Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Lymphedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27852824&form=6&db=m Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Lymphedema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28490670&form=6&db=m Leukotriene B4 antagonism ameliorates experimental lymphedema. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Lymphocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9850081&form=6&db=m Reduced COX-2 protein in colorectal cancer with defective mismatch repair. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2123966&form=6&db=m Mutagenic response of mouse lymphoma cells after activation of benzidine and 2-aminofluorene with purified prostaglandin H synthase. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2840273&form=6&db=m Glucocorticoid-induced lymphoma cell growth inhibition: the role of leukotriene B4. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949405&form=6&db=m An immunohistochemical study of cyclooxygenase-2 expression in various feline neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654083&form=6&db=m Increased cyclooxygenase-2 (COX-2): a potential role in the pathogenesis of lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222024&form=6&db=m Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15359639&form=6&db=m Cyclooxygenase-2 (Cox-2) expression in lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911099&form=6&db=m Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16790692&form=6&db=m Angiogenesis in nodal B cell lymphomas: a high throughput study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049184&form=6&db=m Clinical significance of cyclooxygenase-2 expression in extranodal natural killer (NK)/T-cell lymphoma, nasal type. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062337&form=6&db=m [Association of abnormal cyclooxygenase-2 gene expression with colorectal carcinoma metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17325901&form=6&db=m Cyclooxygenase-2 expression in non-Hodgkin's lymphomas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671709&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in primary central nervous system lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17823287&form=6&db=m Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18344086&form=6&db=m [Protein expression and clinical significance of cyclooxygenase 2 and nuclear factor kappa B in gastric mucosa-associated lymphoid tissue lymphoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18800677&form=6&db=m [The expression of COX-2 mRNA and protein in human laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19120890&form=6&db=m Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: its relation to vascular endothelial growth factor and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19672427&form=6&db=m Regression of follicular lymphoma with Devil's Claw: coincidence or causation? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19833390&form=6&db=m Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19885582&form=6&db=m Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346139&form=6&db=m Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21980345&form=6&db=m Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24505512&form=6&db=m Cyclooxygenase-2 expression in lymphoma in north-west of iran. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24637636&form=6&db=m COX-2 independent effects of Celecoxib sensitize Lymphoma B cells to TRAIL-mediated apoptosis. ongoing research,unassigned 4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24813155&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in normal, hyperplastic and neoplastic canine lymphoid tissues. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25503726&form=6&db=m A functional (pro)renin receptor is expressed in human lymphocytes and monocytes. ongoing research,unassigned 4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25625242&form=6&db=m Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25857479&form=6&db=m Korean Red Ginseng Extract Enhances the Anticancer Effects of Imatinib Mesylate Through Abrogation p38 and STAT5 Activation in KBM-5 Cells. causal interaction,unassigned 2,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26660326&form=6&db=m Ibuprofen abates cypermethrin-induced expression of pro-inflammatory mediators and mitogen-activated protein kinases and averts the nigrostriatal dopaminergic neurodegeneration. causal interaction,unassigned 4,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870269&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and interleukin-32 in primary gastric B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27288923&form=6&db=m Anti-neuroinflammatory and neuroprotective effects of the Lindera neesiana fruit in vitro. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29764431&form=6&db=m Cyclooxygenase-2 immunoexpression in intestinal epithelium and lamina propria of cats with inflammatory bowel disease and low grade alimentary lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683818&form=6&db=m The cyclooxygenase-2/prostaglandin E2 pathway and its role in the pathogenesis of human and dog hematological malignancies. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988786&form=6&db=m Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-?B signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31187468&form=6&db=m Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31341363&form=6&db=m Raddeanin A promotes apoptosis and ameliorates 5-fluorouracil resistance in cholangiocarcinoma cells. unassigned -
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32365663&form=6&db=m Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414698&form=6&db=m Inflammatory myofibroblastic tumor in the head and neck-a neoplasm with both tumor features and inflammation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654072&form=6&db=m Inhibition of cyclooxygenase-2: a new targeted therapy for B-cell lymphoma? causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17668203&form=6&db=m Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. ongoing research,unassigned 2,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19120890&form=6&db=m Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: its relation to vascular endothelial growth factor and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19833390&form=6&db=m Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22225575&form=6&db=m Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis. causal interaction,unassigned 2,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25574189&form=6&db=m Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26026079&form=6&db=m Combination Efficacy of Astragalus membranaceus and Curcuma wenyujin at Different Stages of Tumor Progression in an Imageable Orthotopic Nude Mouse Model of Metastatic Human Ovarian Cancer Expressing Red Fluorescent Protein. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26660326&form=6&db=m Ibuprofen abates cypermethrin-induced expression of pro-inflammatory mediators and mitogen-activated protein kinases and averts the nigrostriatal dopaminergic neurodegeneration. causal interaction,unassigned 4,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808646&form=6&db=m Hazelnut and neuroprotection: Improved memory and hindered anxiety in response to intra-hippocampal A? injection. unassigned -
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870269&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and interleukin-32 in primary gastric B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27288923&form=6&db=m Anti-neuroinflammatory and neuroprotective effects of the Lindera neesiana fruit in vitro. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27965474&form=6&db=m Açaí Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice. diagnostic usage,unassigned 2,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28450936&form=6&db=m The traditional Korean herbal medicine Ga-Gam-Nai-Go-Hyan suppresses testosterone-induced benign prostatic hyperplasia by regulating inflammatory responses and apoptosis. unassigned -
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28544385&form=6&db=m Korean Red Ginseng Extract Enhances the Anticancer Effects of Sorafenib through Abrogation of CREB and c-Jun Activation in Renal Cell Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28678054&form=6&db=m Exercise Training Prevents Dexamethasone-induced Rarefaction. diagnostic usage,unassigned 2,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804691&form=6&db=m Combination of celecoxib (Celebrex(®)) and CD19 CAR-redirected CTL immunotherapy for the treatment of B-cell non-Hodgkin's lymphomas. unassigned -
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399358&form=6&db=m Predictive biomarkers for combined chemotherapy with 5-fluorouracil and cisplatin in oro- and hypopharyngeal cancers. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29454324&form=6&db=m Investigation of the anti-cataractogenic mechanisms of curcumin through in vivo and in vitro studies. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30986204&form=6&db=m Avicularin Relieves Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice. diagnostic usage,unassigned 3,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30988786&form=6&db=m Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-?B signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31187468&form=6&db=m Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31222746&form=6&db=m Silencing of PTGS2 exerts promoting effects on angiogenesis endothelial progenitor cells in mice with ischemic stroke via repression of the NF-?B signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31252679&form=6&db=m Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31341363&form=6&db=m Raddeanin A promotes apoptosis and ameliorates 5-fluorouracil resistance in cholangiocarcinoma cells. unassigned -
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31684176&form=6&db=m Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation. causal interaction,unassigned 1,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31772707&form=6&db=m Cicadidae Periostracum, the Cast-Off Skin of Cicada, Protects Dopaminergic Neurons in a Model of Parkinson's Disease. therapeutic application,unassigned 1,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32133068&form=6&db=m Ameliorative effects of silymarin on HCl-induced acute lung injury in rats; role of the Nrf-2/HO-1 pathway. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32183146&form=6&db=m Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells. causal interaction,unassigned 4,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32304100&form=6&db=m Statin and cyclooxygenase-2 inhibitors improve survival in newly diagnosed diffuse large B-cell lymphoma: a large population-based study of 4913 subjects. therapeutic application,unassigned 3,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640096&form=6&db=m Syringic acid modulates molecular marker-involved cell proliferation, survival, apoptosis, inflammation, and angiogenesis in DMBA-induced oral squamous cell carcinoma in Syrian hamsters. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33639076&form=6&db=m Phyllanthin Averts Oxidative Stress and Neuroinflammation in Cerebral Ischemic-Reperfusion Injury through Modulation of the NF-?B and AMPK/Nrf2 Pathways. diagnostic usage,unassigned 1,0
1.14.99.1 Lymphoma, B-Cell, Marginal Zone http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11033048&form=6&db=m Helicobacter pylori infection and gastrin and cyclooxygenase expression in gastric and colorectal malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Lymphoma, B-Cell, Marginal Zone http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222024&form=6&db=m Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Lymphoma, B-Cell, Marginal Zone http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18344086&form=6&db=m [Protein expression and clinical significance of cyclooxygenase 2 and nuclear factor kappa B in gastric mucosa-associated lymphoid tissue lymphoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Lymphoma, B-Cell, Marginal Zone http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19120890&form=6&db=m Microcirculatory alteration in low-grade gastric mucosa-associated lymphoma by Helicobacter heilmannii infection: its relation to vascular endothelial growth factor and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31187468&form=6&db=m Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32304100&form=6&db=m Statin and cyclooxygenase-2 inhibitors improve survival in newly diagnosed diffuse large B-cell lymphoma: a large population-based study of 4913 subjects. therapeutic application,unassigned 3,0
1.14.99.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3100032&form=6&db=m Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951238&form=6&db=m High-Dose celecoxib and metronomic "low-dose" cyclophosphamide is an effective and safe therapy in patients with relapsed and refractory aggressive histology non-Hodgkin's lymphoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17697546&form=6&db=m [Correlation of cyclooxygenase-2 expression to P-glycoprotein expression in B-cell non-Hodgkin's lymphoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691115&form=6&db=m Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21980345&form=6&db=m Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23205085&form=6&db=m Lymphangiogenesis in non-Hodgkin's lymphoma and its correlation with cyclooxygenase-2 and vascular endothelial growth factor-C. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23523954&form=6&db=m Concurrent targeting of EP1/EP4 receptors and COX-2 induces synergistic apoptosis in KSHV and EBV associated non-Hodgkin lymphoma cell lines. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Lymphoma, Non-Hodgkin http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31187468&form=6&db=m Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Lymphoma, Primary Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21980345&form=6&db=m Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Lymphoma, Primary Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Lymphoma, T-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22731506&form=6&db=m Cyclooxygenase-2 is not expressed by canine cutaneous epitheliotropic T-cell lymphoma. unassigned -
1.14.99.1 Lymphoma, T-Cell, Cutaneous http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428208&form=6&db=m COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF). causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Lymphoma, T-Cell, Peripheral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25674239&form=6&db=m Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-?B pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options. therapeutic application,unassigned 2,0
1.14.99.1 Lymphopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21782872&form=6&db=m The COX-2 gene promoter polymorphism -765 delays CD4 T-cell reconstitution after lymphocyte depletion with antithymocyte globulins. therapeutic application,unassigned 1,0
1.14.99.1 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16340537&form=6&db=m Oral administration of lumiracoxib reduces choroidal neovascular membrane development in the rat laser-trauma model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18827739&form=6&db=m Expression of cyclooxygenase-2 in choroidal neovascular membranes from age-related macular degeneration patients. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21928264&form=6&db=m Cyclooxygenase inhibitor improved an exudative lesion of choroidal neovascularization in age-related macular degeneration. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Macular Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23132511&form=6&db=m Progression of macular atrophy after PDT combined with the COX-2 inhibitor Nabumetone in the treatment of neovascular ARMD. therapeutic application,unassigned 4,0
1.14.99.1 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16105620&form=6&db=m Cyclooxygenase-2 inhibitors: a new therapeutic option in the treatment of macular edema after cataract surgery. therapeutic application,unassigned 4,0
1.14.99.1 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17397743&form=6&db=m Successful treatment of cystoid macular edema with valdecoxib. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Macular Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29912514&form=6&db=m The opinion of the Expert Group of the Polish Society of Ophthalmology on using nepafenac in the prevention of postoperative macular edema after cataract surgery in diabetic patients. causal interaction,unassigned 4,0
1.14.99.1 Magnesium Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3016750&form=6&db=m Alteration of prostanoid metabolism in rats with magnesium deficiency. causal interaction,unassigned 3,0
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2685716&form=6&db=m Suppression of in-vitro lymphoproliferative responses in acute malaria patients can be partially reversed by indomethacin. ongoing research,unassigned 2,0
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11076710&form=6&db=m Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767831&form=6&db=m Cyclooxygenase-2 in the pathogenesis of murine cerebral malaria. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15502882&form=6&db=m Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619186&form=6&db=m Suppression of Prostaglandin E2 by Malaria Parasite Products and Antipyretics Promotes Overproduction of Tumor Necrosis Factor- alpha : Association with the Pathogenesis of Childhood Malarial Anemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16678181&form=6&db=m Immunopathogenesis of cerebral malaria. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20144201&form=6&db=m Chronic infection during placental malaria is associated with up-regulation of cycloxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743193&form=6&db=m Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31664161&form=6&db=m Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Malaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33786046&form=6&db=m Activities of Andrographis paniculata (AS201-01) Tablet on Cox-2 and Prostaglandin Expression of Placental of Plasmodium berghei Infected Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10814798&form=6&db=m Focal accumulation of cyclooxygenase-1 (COX-1) and COX-2 expressing cells in cerebral malaria. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767831&form=6&db=m Cyclooxygenase-2 in the pathogenesis of murine cerebral malaria. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743193&form=6&db=m Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Malaria, Cerebral http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27887739&form=6&db=m Differences in the modulation of reactive species, lipid bodies, cyclooxygenase-2, 5-lipoxygenase and PPAR-? in cerebral malaria-susceptible and resistant mice. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Malaria, Falciparum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11076710&form=6&db=m Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Malaria, Falciparum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15502882&form=6&db=m Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11712791&form=6&db=m Malnutrition and cachexia in ovarian cancer patients: pathophysiology and management. therapeutic application,unassigned 3,0
1.14.99.1 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499878&form=6&db=m NADPH oxidase and enhanced superoxide generation in intrauterine undernourished rats: involvement of the renin-angiotensin system. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19293133&form=6&db=m Effect of periconceptional undernutrition in sheep on late gestation expression of mRNA and protein from genes involved in fetal adrenal steroidogenesis and placental prostaglandin production. causal interaction,unassigned 3,0
1.14.99.1 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12090811&form=6&db=m Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18552976&form=6&db=m Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches. diagnostic usage,therapeutic application,unassigned 4,4,0
1.14.99.1 Mania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20021459&form=6&db=m Mood-stabilizers target the brain arachidonic acid cascade. unassigned -
1.14.99.1 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1649514&form=6&db=m The combined use of lipoxygenase and cyclooxygenase inhibitors in Klebsiella pneumoniae-induced bovine mastitis. therapeutic application,unassigned 4,0
1.14.99.1 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6814372&form=6&db=m Effect of prostaglandin synthetase inhibitors on mammary blood flow during experimentally induced mastitis in lactating goats. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6814373&form=6&db=m Effect of prostaglandin synthetase inhibitors on endotoxin-induced mastitis. ongoing research,unassigned 1,0
1.14.99.1 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24844733&form=6&db=m Dietary Selenium Deficiency Exacerbates Lipopolysaccharide-Induced Inflammatory Response in Mouse Mastitis Models. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,1
1.14.99.1 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24844929&form=6&db=m Activity of cyclooxygenase-2 and nitric oxide in milk leucocytes following intramammary inoculation of a bio-response modifier during bovine Staphylococcus aureus subclinical mastitis. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25752858&form=6&db=m Expression of cyclooxygenase-2 in the mammary gland tissue of goats affected with caprine contagious agalactia. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Mastitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34073753&form=6&db=m Flunixin Meglumine Reduces Milk Isoprostane Concentrations in Holstein Dairy Cattle Suffering from Acute Coliform Mastitis. unassigned -
1.14.99.1 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900681&form=6&db=m Mast cells and cell-to-cell interactions in airways. unassigned -
1.14.99.1 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2936077&form=6&db=m Identification of mRNA for prostaglandin endoperoxide synthetase from mouse mastocytoma P-815 cells. ongoing research,unassigned 3,0
1.14.99.1 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6135418&form=6&db=m Identification of the mRNA and polypeptide subunit for prostaglandin endoperoxide synthase from mouse mastocytoma P-815 cells. ongoing research,unassigned 3,0
1.14.99.1 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6768397&form=6&db=m Sodium n-butyrate induces prostaglandin synthetase activity in mastocytoma P-815 cells. ongoing research,unassigned 1,0
1.14.99.1 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8217194&form=6&db=m Mitogen-inducible prostaglandin G/H synthase is expressed in canine mastocytoma cells. ongoing research,unassigned 4,0
1.14.99.1 Mastocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16547010&form=6&db=m Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. unassigned -
1.14.99.1 Mastocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1490622&form=6&db=m Mast cell disease. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Mastocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9837692&form=6&db=m Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis. causal interaction,unassigned 4,0
1.14.99.1 Mastocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30987265&form=6&db=m Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis. unassigned -
1.14.99.1 Mastocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31936203&form=6&db=m Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway. therapeutic application,unassigned 1,0
1.14.99.1 Mastocytosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32560278&form=6&db=m Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Mastocytosis, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2880686&form=6&db=m Systemic mastocytosis: management of an unusual case with histamine (H1 and H2) antagonists and cyclooxygenase inhibition. therapeutic application,unassigned 1,0
1.14.99.1 Meconium Aspiration Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10328330&form=6&db=m Meconium stimulates cyclooxygenase-2 expression in rat lungs. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Meconium Aspiration Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12621123&form=6&db=m Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15460407&form=6&db=m [Expression and clinical significance of cyclooxygenase-2 in medulloblastoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18715952&form=6&db=m Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,3
1.14.99.1 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20526717&form=6&db=m Celecoxib enhances radiosensitivity in medulloblastoma-derived CD133-positive cells. causal interaction,unassigned 3,0
1.14.99.1 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21946257&form=6&db=m Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2
1.14.99.1 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22707305&form=6&db=m MT1-MMP expression level status dictates the in vitro action of lupeol on inflammatory biomarkers MMP-9 and COX-2 in medulloblastoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3
1.14.99.1 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28417956&form=6&db=m Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation. unassigned -
1.14.99.1 Megacolon http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18458699&form=6&db=m [Mechanism of exacerbation of colonic damage in experimental colitis treated with celecoxib] causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2501827&form=6&db=m Influence of morphology and malignancy of three new human melanoma cell lines on the cyclooxygenase pathway. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3485703&form=6&db=m In vitro inhibition of interleukin-2 production by peripheral blood lymphocytes from stage III melanoma patients by prostaglandin E2: enhancement of lymphocyte proliferation by exogenous interleukin-2 plus indomethacin. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6972628&form=6&db=m Indomethacin enhancement of immunocompetence in melanoma patients. ongoing research,unassigned 3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8900440&form=6&db=m Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417761&form=6&db=m Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10749148&form=6&db=m Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196178&form=6&db=m Expression of cyclooxygenase 2 in human malignant melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11725205&form=6&db=m Progression and NSAID-induced apoptosis in malignant melanomas are independent of cyclooxygenase II. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12049957&form=6&db=m Comparing contrast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: preliminary results. ongoing research,unassigned 2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679317&form=6&db=m Cyclooxygenase-2 inhibition improves macrophage function in melanoma and increases the antineoplastic activity of interferon gamma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12777984&form=6&db=m Cyclooxygenase-2 promoter for tumour-specific targeting of adenoviral vectors to melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12879280&form=6&db=m Metronomic oral low-dose treosulfan chemotherapy combined with cyclooxygenase-2 inhibitor in pretreated advanced melanoma: a pilot study. therapeutic application,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12956275&form=6&db=m Cyclooxygenase-2 expression in uveal melanoma: novel classification of mixed-cell-type tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688483&form=6&db=m Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15251468&form=6&db=m Prostaglandin production by melanocytic cells and the effect of alpha-melanocyte stimulating hormone. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15696177&form=6&db=m Evaluation of tumor-specific promoter activities in melanoma. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15772428&form=6&db=m Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16029699&form=6&db=m Use of cyclooxygenase inhibitors and risk of melanoma in high-risk patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080553&form=6&db=m Cyclooxygenase-2 expression in brain metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16269535&form=6&db=m Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma: involvement of alpha-melanocyte-stimulating hormone-mediated inhibition of the nuclear factor kappaB/cyclooxygenase-2 pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16400521&form=6&db=m Cyclooxygenase inhibition in early onset of tumor growth and related angiogenesis evaluated in EP1 and EP3 knockout tumor-bearing mice. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16432453&form=6&db=m Expression of cyclooxygenase-2 in benign naevi and during human cutaneous melanoma progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16487513&form=6&db=m Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507396&form=6&db=m Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16718274&form=6&db=m Complete and long-lasting regression of disseminated multiple skin melanoma metastases under treatment with cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980601&form=6&db=m Temozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17013098&form=6&db=m Cyclooxygenase-2 inhibition and regression of metastatic melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17070520&form=6&db=m Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. causal interaction,unassigned 1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17361263&form=6&db=m Immunohistochemical expression of COX-2 and c-kit in metastatic uveal melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17434930&form=6&db=m The use of a cyclooxygenase-2 inhibitor (Nepafenac) in an ocular and metastatic animal model of uveal melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17499752&form=6&db=m Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17505259&form=6&db=m Cyclooxygenase-2 (COX-2): first immunohistochemical marker distinguishing early cutaneous melanomas from benign melanocytic skin tumours. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17603773&form=6&db=m Cyclooxygenase-2 expression in human irradiated uveal melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17673806&form=6&db=m Melanoma inhibition by cyclooxygenase inhibitors: role of interleukin-6 suppression, a putative mechanism of action, and clinical implications. therapeutic application,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18042295&form=6&db=m The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18049486&form=6&db=m Amfenac increases the radiosensitivity of uveal melanoma cell lines. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18293189&form=6&db=m Expression of COX-2 and prognostic outcome in uveal melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18297687&form=6&db=m Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18454317&form=6&db=m Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival. causal interaction,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537861&form=6&db=m Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma during malignant melanoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18722548&form=6&db=m Expression of Ca(2+)-independent and Ca(2+)-dependent phospholipases A(2) and cyclooxygenases in human melanocytes and malignant melanoma cell lines. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18984785&form=6&db=m Cyclooxygenase-2 expression in equine tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19039588&form=6&db=m Prognostic significance of tumor iNOS and COX-2 in stage III malignant cutaneous melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430402&form=6&db=m COX-2 expression in malignant melanoma: a novel prognostic marker? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19432844&form=6&db=m Cyclo-oxygenase-2 expression in photon-radiated and non-radiated uveal melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19543125&form=6&db=m Cyclooxygenase-2 immunohistochemistry in human melanoma: differences between results obtained with different antibodies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19639032&form=6&db=m Cyclooxygenase 2 (COX2) and Peroxisome Proliferator-Activated Receptor Gamma (PPARG) Are Stage-Dependent Prognostic Markers of Malignant Melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19724275&form=6&db=m NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737966&form=6&db=m Leukotriene B4 creates a favorable microenvironment for murine melanoma growth. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19747926&form=6&db=m PKCalpha-MAPK/ERK-phospholipase A(2) signaling is required for human melanoma-enhanced brain endothelial cell proliferation and motility. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19795944&form=6&db=m Expression of cyclooxygenase-2 in canine uveal melanocytic neoplasms. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032377&form=6&db=m Expression of the CD117, COX-2 and HSP90 antigens and cell proliferation in fine-needle-aspirated cells from metastatic melanomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20207364&form=6&db=m COX-1 and COX-2 Expression in Canine Cutaneous, Oral and Ocular Melanocytic Tumours. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209608&form=6&db=m Intratumoral forkhead box P3-positive regulatory T cells predict poor survival in cyclooxygenase-2-positive uveal melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20404772&form=6&db=m Similar antineoplastic effects of nimesulide, a selective COX-2 inhibitor, and prostaglandin E1 on B16-F10 murine melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20482620&form=6&db=m Prostaglandin D production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production. ongoing research,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20944117&form=6&db=m Cytoplasmic phospholipase A2 metabolites play a critical role in pulmonary tumor metastasis in mice. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20974686&form=6&db=m Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E2 and prostaglandin E2 receptors. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21182498&form=6&db=m Immunohistochemical expression of cyclooxygenage-2 in melanocytic skin lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268068&form=6&db=m Suppression of the proinflammatory response of metastatic melanoma cells increases TRAIL-induced apoptosis. causal interaction,unassigned 3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21292918&form=6&db=m Cyclooxygenase-2 Expression Is Related With Localization, Proliferation, and Overall Survival in Canine Melanocytic Neoplasms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21384343&form=6&db=m Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21738696&form=6&db=m Grape seed proanthocyanidins inhibit melanoma cell invasiveness by reduction of PGE2 synthesis and reversal of epithelial-to-mesenchymal transition. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21867538&form=6&db=m Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21910007&form=6&db=m Regulation of apoptosis in human melanoma and neuroblastoma cells by statins, sodium arsenite and TRAIL: a role of combined treatment versus monotherapy. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21967460&form=6&db=m Ipobscurine, an indole alkaloid from Ipomoea obscura, inhibits tumor cell invasion and experimental metastasis by inducing apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022384&form=6&db=m Green tea catechins reduce invasive potential of human melanoma cells by targeting COX-2, PGE2 receptors and epithelial-to-mesenchymal transition. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22025079&form=6&db=m The metastatic microenvironment: Brain-residing melanoma metastasis and dormant micrometastasis. diagnostic usage,unassigned 3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22045024&form=6&db=m DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and ?-catenin nuclear translocation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22120676&form=6&db=m Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228276&form=6&db=m The value of cyclooxygenase-2 expression in differentiating between early melanomas and histopathologically difficult types of benign human skin lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553608&form=6&db=m Expression and significance of factors related to angiogenesis in choroidal melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23112250&form=6&db=m Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23146632&form=6&db=m Visualization of cyclooxygenase-2 using a 2,3-diarylsubstituted indole-based inhibitor and confocal laser induced cryofluorescence microscopy at 20K in melanoma cells in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23170076&form=6&db=m Sarcophine-diol inhibits expression of COX-2, inhibits activity of cPLA?, enhances degradation of PLA? and PLC(?)1 and Inhibits cell membrane permeability in mouse melanoma B??F?? cells. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23411479&form=6&db=m Expression of thymidine phosphorylase and cyclooxygenase-2 in melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23420676&form=6&db=m Endogenous PGE(2) induces MCP-1 expression via EP4/p38 MAPK signaling in melanoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23728342&form=6&db=m Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via ?9?1 integrin. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23834707&form=6&db=m Antiproliferative Diarylpyrazole Derivatives as Dual Inhibitors of the ERK Pathway and COX-2. therapeutic application,unassigned 2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24041928&form=6&db=m Anticancer activity of anandamide in human cutaneous melanoma cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24052986&form=6&db=m [Evaluation of COX-2 protein expression in melanocytic nevi in children]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24077511&form=6&db=m Chemoprevention of skin melanoma: facts and myths. therapeutic application,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24300090&form=6&db=m Enhanced in-vitro and in-vivo suppression of A375 melanoma by combined IL-24/OSM adenoviral-mediated gene therapy. therapeutic application,unassigned 1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24656746&form=6&db=m Antitumor effects of celecoxib in COX-2 expressing and non-expressing canine melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24677090&form=6&db=m Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP?2 and MMP?9 via downregulation of NF-?B signaling pathway. causal interaction,unassigned 3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24878108&form=6&db=m Different detectability of cyclooxygenase-2 (COX-2) protein in standard paraffin sections and tissue microarrays of human melanomas and naevi - Comparative study. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25060715&form=6&db=m Association of promoter polymorphism -765G>C in the PTGS2 gene with malignant melanoma in Italian patients and its correlation to gene expression in dermal fibroblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25304264&form=6&db=m Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25612618&form=6&db=m Vemurafenib Resistance Signature by Proteome Analysis Offers New Strategies and Rational Therapeutic Concepts. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25637530&form=6&db=m Optical imaging of COX-2: Studies on an autofluorescent 2,3-diaryl-substituted indole-based cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26473949&form=6&db=m Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via ?9?1 integrin. causal interaction,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26547585&form=6&db=m Quantitative measurement of iNOS expression in melanoma, nasopharyngeal, colorectal, and breast tumors of Tunisian patients: comparative study and clinical significance. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26595378&form=6&db=m Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26608958&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 (COX-2) in oral nevi and melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26801201&form=6&db=m Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807314&form=6&db=m Therapeutic intervention of proanthocyanidins on the migration capacity of melanoma cells is mediated through PGE2 receptors and ?-catenin signaling molecules. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959112&form=6&db=m Radiation therapy generates platelet-activating factor agonists. causal interaction,unassigned 1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27010501&form=6&db=m Evaluation of the anti-inflammatory action of curcumin analog (DM1): Effect on iNOS and COX-2 gene expression and autophagy pathways. ongoing research,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27105172&form=6&db=m Investigating associations of cyclooxygenase-2 expression with angiogenesis, proliferation, macrophage and T-lymphocyte infiltration in canine melanocytic tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27235711&form=6&db=m Apoptotic effect of eugenol envolves G2/M phase abrogation accompanied by mitochondrial damage and clastogenic effect on cancer cell in vitro. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27391144&form=6&db=m Intratumoral expression of cyclooxygenase-2 (COX-2) is a negative prognostic marker for patients with cutaneous melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27494851&form=6&db=m Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27769779&form=6&db=m Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27777130&form=6&db=m ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28231855&form=6&db=m COX-2 expression positively correlates with PD-L1 expression in human melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386327&form=6&db=m Reduction of COX-2 through modulating miR-124/SPHK1 axis contributes to the antimetastatic effect of alpinumisoflavone in melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28604419&form=6&db=m Prognostic significance of cyclooxygenase 2 and phosphorylated Akt1 overexpression in primary nonmetastatic and metastatic cutaneous melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28733349&form=6&db=m Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765120&form=6&db=m Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28865485&form=6&db=m Combination therapy of PKC? and COX-2 inhibitors synergistically suppress melanoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28899685&form=6&db=m The tumor-promoting role of TRIP4 in melanoma progression and its involvement in response to BRAF-targeted therapy. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29064018&form=6&db=m Impact of Human Adipose Tissue-Derived Stem Cells on Malignant Melanoma Cells in An In Vitro Co-culture Model. unassigned -
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29287164&form=6&db=m Cyclooxygenase-2 expression in the eyes of cats with and without uveitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29297092&form=6&db=m Conjunctival melanoma: association of cyclooxygenase-2 tumor expression to prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29794562&form=6&db=m Tumour-infiltrating lymphocytes, programmed death ligand 1 and cyclooxygenase-2 expression in skin melanoma of elderly patients: clinicopathological correlations. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29808460&form=6&db=m The role of lipid signaling in the progression of malignant melanoma. unassigned -
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021726&form=6&db=m Aspirin Suppresses PGE2 and Activates AMP Kinase to Inhibit Melanoma Cell Motility, Pigmentation, and Selective Tumor Growth In Vivo. unassigned -
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30098313&form=6&db=m MicroRNA-143-3p inhibits growth and invasiveness of melanoma cells by targeting cyclooxygenase-2 and inversely correlates with malignant melanoma progression. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30562372&form=6&db=m NF-?B p65 and p105 implicate in interleukin 1?-mediated COX-2 expression in melanoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30575644&form=6&db=m Prognostic significance of CD163 expression and its correlation with cyclooxygenase-2 and vascular endothelial growth factor expression in cutaneous melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30596805&form=6&db=m Retraction: Green Tea Catechins Reduce Invasive Potential of Human Melanoma Cells by Targeting COX-2, PGE2 Receptors and Epithelial-to-Mesenchymal Transition. ongoing research,unassigned 2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30800067&form=6&db=m Anti-metastatic Properties of Naproxen-HBTA in a Murine Model of Cutaneous Melanoma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092422&form=6&db=m Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31377156&form=6&db=m Resveratrol-mediated inhibition of cyclooxygenase-2 in melanocytes suppresses melanogenesis through extracellular signal-regulated kinase 1/2 and phosphoinositide 3-kinase/Akt signalling. ongoing research,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31528165&form=6&db=m Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31675116&form=6&db=m Immunohistochemical detectability of cyclooxygenase-2 expression in cells of human melanocytic skin lesions: A methodological review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31689521&form=6&db=m The association between nonsteroidal anti-inflammatory drugs and skin cancer: Different responses in American and European populations. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31696069&form=6&db=m The role of immunohistochemistry expression of COX-2 in differentiating pigmented benign and malignant skin neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31817719&form=6&db=m ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920649&form=6&db=m Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31968661&form=6&db=m Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32044411&form=6&db=m Prognostic Significance of CD200 Protein Expression and its Correlation with COX-2 in Cutaneous Melanoma. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32243925&form=6&db=m Karyopherin ? 2 promotes proliferation, migration and invasion through activating NF-?B/p65 signaling pathways in melanoma cells. unassigned -
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32264335&form=6&db=m pH-Responsive nanoparticles based on ibuprofen prodrug as drug carriers for inhibition of primary tumor growth and metastasis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32296574&form=6&db=m COX-2 as a potential biomarker and therapeutic target in melanoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32323423&form=6&db=m Cyclooxygenase-2 expression is associated with infiltration of inflammatory cells in oral and skin canine melanomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32388516&form=6&db=m Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508794&form=6&db=m Cyclooxygenase-2 Facilitates Newcastle Disease Virus Proliferation and Is as a Target for Canthin-6-One Antiviral Activity. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570264&form=6&db=m Enhanced expression of cyclooxygenase-2 related multi-drug resistance gene in melanoma and osteosarcoma cell lines by TSG-6 secreted from canine adipose-derived mesenchymal stem/stromal cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33648517&form=6&db=m Correction to: Combination therapy of PKC? and COX-2 inhibitors synergistically suppress melanoma metastasis. therapeutic application,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33688233&form=6&db=m High Expression of COX-2 Associated with the Depth of Invasion on Acral Melanoma by Increasing TGF-?1. causal interaction,unassigned 4,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751829&form=6&db=m The role of COX expression in the prognostication of overall survival of canine and feline cancer: A systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34086522&form=6&db=m Plasma circulating cell free messenger RNA as a potential biomarker of melanoma. diagnostic usage,unassigned 3,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34204367&form=6&db=m In Vitro Effects of Selective COX and LOX Inhibitors and Their Combinations with Antineoplastic Drugs in the Mouse Melanoma Cell Line B16F10. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,4
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34497154&form=6&db=m Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34513965&form=6&db=m COX-2 Silencing in Canine Malignant Melanoma Inhibits Malignant Behaviour. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679317&form=6&db=m Cyclooxygenase-2 inhibition improves macrophage function in melanoma and increases the antineoplastic activity of interferon gamma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17499752&form=6&db=m Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18479787&form=6&db=m Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Melanoma, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21867538&form=6&db=m Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Melanosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22506937&form=6&db=m siRNA-mediated knock-down of COX-2 in melanocytes suppresses melanogenesis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Melanosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26381025&form=6&db=m CD4, IL-17, and COX-2 Are Associated With Subclinical Inflammation in Malar Melasma. diagnostic usage,unassigned 2,0
1.14.99.1 Melioidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675544&form=6&db=m Post-exposure therapeutic efficacy of COX-2 inhibition against Burkholderia pseudomallei. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Melioidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27792775&form=6&db=m Immune Modulation as an Effective Adjunct Post-exposure Therapeutic for B. pseudomallei. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Melkersson-Rosenthal Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17577330&form=6&db=m Expression of protease-activated receptor-1 and -2 in orofacial granulomatosis. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12928578&form=6&db=m Protective effect of flavonoids against aging- and lipopolysaccharide-induced cognitive impairment in mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309832&form=6&db=m The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17556794&form=6&db=m Inhibitor of cyclooxygenase-2 protects against amyloid beta peptide-evoked memory impairment in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17639600&form=6&db=m Systemic and developmental exposure to lead causes spatial memory deficits and a reduction in COX-2 immunoreactivity in the hippocampus of male rats. causal interaction,unassigned 4,0
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19447162&form=6&db=m Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23083210&form=6&db=m Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26922073&form=6&db=m Meloxicam-loaded nanocapsules as an alternative to improve memory decline in an Alzheimer's disease model in mice: involvement of Na(+), K(+)-ATPase. unassigned -
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28466254&form=6&db=m Celecoxib Alleviates Memory Deficits by Downregulation of COX-2 Expression and Upregulation of the BDNF-TrkB Signaling Pathway in a Diabetic Rat Model. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32147541&form=6&db=m Chronic acrylamide exposure induced glia cell activation, NLRP3 infl-ammasome upregulation and cognitive impairment. causal interaction,unassigned 4,0
1.14.99.1 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34267346&form=6&db=m Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1910078&form=6&db=m A study on the biological behavior of human brain tumors. Part I. Arachidonic acid metabolism and DNA content. causal interaction,unassigned 3,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902865&form=6&db=m Cyclooxygenase-2 (COX-2) expression in human meningioma as a function of tumor grade. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693827&form=6&db=m The eicosanoid cascade: possible role in gliomas and meningiomas. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15542977&form=6&db=m Meningioma: an update. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16235684&form=6&db=m Ubiquitous expression of cyclooxygenase-2 in meningiomas and decrease in cell growth following in vitro treatment with the inhibitor celecoxib: potential therapeutic application. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17177201&form=6&db=m Celecoxib inhibits meningioma tumor growth in a mouse xenograft model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525632&form=6&db=m Cyclooxygenase-2 (COX-2) overexpression in meningiomas: real time PCR and immunohistochemistry. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952743&form=6&db=m Expression of Cyclooxygenase-2 and Its Correlation with Vasogenic Brain Edema in Human Intracranial Meningiomas. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17961044&form=6&db=m Inflammatory response and meningioma tumorigenesis and the effect of cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17961045&form=6&db=m Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18418552&form=6&db=m Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19691646&form=6&db=m Cyclooxygenase-2 (COX-2) expression in canine intracranial meningiomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20054806&form=6&db=m Clinicopathological variables, immunophenotype, chromosome 1p36 loss and tumour recurrence of 247 meningiomas grade I and II. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22209769&form=6&db=m Comparative morphological and immunohistochemical study of human meningioma after intracranial transplantation into nude mice. ongoing research,unassigned 4,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23143216&form=6&db=m Effect of systemic celecoxib on human meningioma after intracranial transplantation into nude mice. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23250387&form=6&db=m Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23508834&form=6&db=m Erratum to: Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23756256&form=6&db=m Significance of COX-2 and VEGF expression in histopathologic grading and invasiveness of meningiomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24779988&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 and brain fatty acid binding protein expression in grades I-II meningiomas: Correlation with tumor grade and clinical outcome after radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25371868&form=6&db=m An observational study on the expression of cyclooxygenase-2 in meningioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30340655&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 (COX-2) is not associated with tumor grade in feline meningiomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32832554&form=6&db=m Identification of a Transcription Factor-microRNA-Gene Coregulation Network in Meningioma through a Bioinformatic Analysis. causal interaction,unassigned 1,0
1.14.99.1 Meningioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903787&form=6&db=m Recurrence/Regrowth in Grade I Meningioma: How to Predict? diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Meningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10405195&form=6&db=m Deregulation of cyclooxygenase and nitric oxide synthase gene expression in the inflammatory cascade triggered by experimental group B streptococcal meningitis in the newborn brain and cerebral microvessels. unassigned -
1.14.99.1 Meningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12490607&form=6&db=m Neuroinflammatory role of prostaglandins during experimental meningitis: evidence suggestive of an in vivo relationship between nitric oxide and prostaglandins. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Meningitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151910&form=6&db=m Cognitive decline with chronic meningitis secondary to a COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Meningitis, Bacterial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2089945&form=6&db=m Superoxide dismutase inhibits brain oedema formation in experimental pneumococcal meningitis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Meningitis, Bacterial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17704356&form=6&db=m Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-{alpha} in the Rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2088249&form=6&db=m Management of cyclical menorrhagia with prostaglandin synthetase inhibitor. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3123043&form=6&db=m Endometrial prostaglandins and menorrhagia: influence of a prostaglandin synthetase inhibitor in vivo. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3304401&form=6&db=m Control of menorrhagia by the cyclo-oxygenase inhibitors naproxen sodium and mefenamic acid. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4064305&form=6&db=m The effect of a prostaglandin synthetase inhibitor, indomethacin, on excessive uterine bleeding. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6102055&form=6&db=m Reduction of menstrual blood loss by naproxen in intrauterine contraceptive device users. therapeutic application,unassigned 1,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6344539&form=6&db=m Prostaglandins and menorrhagia. therapeutic application,unassigned 3,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6437699&form=6&db=m Treatment of IUD related menorrhagia by indomethacin. therapeutic application,unassigned 1,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8043556&form=6&db=m Assessment of medical treatments for menorrhagia. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17371607&form=6&db=m Medical therapies for chronic menorrhagia. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17531608&form=6&db=m The levonorgestrel-releasing intrauterine system as an alternative to hysterectomy in peri-menopausal women. therapeutic application,unassigned 4,0
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19014794&form=6&db=m Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,2
1.14.99.1 Menorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23788841&form=6&db=m The effect of oral contraceptives on aromatase and Cox-2 expression in the endometrium of patients with idiopathic menorrhagia or adenomyosis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10919635&form=6&db=m Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633712&form=6&db=m Use of cyclooxygenase-2 inhibition to enhance the efficacy of immunotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15115874&form=6&db=m Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15486399&form=6&db=m Malignant pleural mesothelioma: update, current management, and newer therapeutic strategies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15964184&form=6&db=m Cyclooxygenase-2 expression predicts survival in malignant pleural mesothelioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136511&form=6&db=m COX-2 overexpression in canine tumors: potential therapeutic targets in oncology. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18831511&form=6&db=m Expression of the embryonic lethal abnormal vision-like protein HuR in human mesothelioma: association with cyclooxygenase-2 and prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19450893&form=6&db=m COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20338775&form=6&db=m May cyclooxygenase-2 (COX-2), p21 and p27 expression affect prognosis and therapeutic strategy of patients with malignant pleural mesothelioma? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20804550&form=6&db=m COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23338544&form=6&db=m Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23729401&form=6&db=m Cyclooxygenase-2, epidermal growth factor receptor, and aromatase signaling in inflammation and mesothelioma. ongoing research,unassigned 1,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25093718&form=6&db=m Statins do not alter the incidence of mesothelioma in asbestos exposed mice or humans. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25175318&form=6&db=m Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31063993&form=6&db=m The Value of COX-2, NF-?B, and Blood Routine Indexes in the Prognosis of Malignant Peritoneal Mesothelioma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Mesothelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34404424&form=6&db=m Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities. causal interaction,unassigned 3,0
1.14.99.1 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060628&form=6&db=m Cyclooxygenase-2 expression is a novel prognostic factor in malignant mesothelioma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15115874&form=6&db=m Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15261433&form=6&db=m Clinico-pathological and biological prognostic factors in pleural malignant mesothelioma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15964184&form=6&db=m Cyclooxygenase-2 expression predicts survival in malignant pleural mesothelioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20338775&form=6&db=m May cyclooxygenase-2 (COX-2), p21 and p27 expression affect prognosis and therapeutic strategy of patients with malignant pleural mesothelioma? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25175318&form=6&db=m Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Mesothelioma, Malignant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34404424&form=6&db=m Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities. causal interaction,unassigned 3,0
1.14.99.1 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12837847&form=6&db=m Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21081215&form=6&db=m Prostaglandins in action indispensable roles of cyclooxygenase-1 and -2 in endothelium-dependent contractions. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679712&form=6&db=m Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Metabolic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32867639&form=6&db=m The emerging role of COX-2, 15-LOX, and PPAR? in metabolic diseases and cancer: An introduction to novel multi-target directed ligands (MTDLs). ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17883899&form=6&db=m The protective role of Kangen-karyu against fructose-induced metabolic syndrome in a rat model. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021698&form=6&db=m Selective COX2 inhibition improves whole body and muscular insulin resistance in fructose-fed rats. ongoing research,unassigned 2,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19106330&form=6&db=m Dietary trans-10, cis-12 conjugated linoleic acid reduces early glomerular enlargement and elevated renal cyclooxygenase-2 levels in young obese fa/fa zucker rats. ongoing research,unassigned 2,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20608065&form=6&db=m [Disturbed synthesis of eicosanoids in patients with metabolic syndrome] diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22115172&form=6&db=m Effect of glycine on the cyclooxygenase pathway of the kidney arachidonic acid metabolism in a rat model of metabolic syndrome. ongoing research,unassigned 4,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22311905&form=6&db=m Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23476105&form=6&db=m Role of cox-2 in vascular inflammation: an experimental model of metabolic syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27179108&form=6&db=m Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism. causal interaction,unassigned 4,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912780&form=6&db=m Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29445240&form=6&db=m High fat diet-induced metabolically obese and normal weight rabbit model shows early vascular dysfunction: mechanisms involved. unassigned -
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29756563&form=6&db=m Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Metabolic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34509494&form=6&db=m ApoA-I mimetics favorably impact cyclooxygenase 2 and bioactive lipids that may contribute to cardiometabolic syndrome in chronic treated HIV. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3
1.14.99.1 Metrorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19757243&form=6&db=m Activation of NF-kappaB and COX-2 expression is associated with breakthrough bleeding in patients using oral contraceptives in extended regimens. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Metrorrhagia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20063991&form=6&db=m The effect of a continuous regimen of drospirenone 3 mg/ethinylestradiol 30 microg on Cox-2 and Ki-67 expression in the endometrium. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10961765&form=6&db=m Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222892&form=6&db=m Rizatriptan versus rizatriptan plus rofecoxib versus rizatriptan plus tolfenamic acid in the acute treatment of migraine. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546262&form=6&db=m Genomic abnormalities in patients with migraine and chronic migraine: preliminary blood gene expression suggests platelet abnormalities. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15853470&form=6&db=m Valdecoxib for the management of chronic and acute pain. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15853474&form=6&db=m Rofecoxib in migraine. therapeutic application,unassigned 4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16492237&form=6&db=m Effects of Parecoxib on Plasma Protein Extravasation and c-Fos Expression in the Rat. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17678972&form=6&db=m A role for brain cyclooxygenase-2 and prostaglandin-E2 in migraine: effects of nitroglycerin. ongoing research,unassigned 3,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17728965&form=6&db=m Randomised, open label, controlled trial of celecoxib in the treatment of acute migraine. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18312401&form=6&db=m A double-blind, randomized, placebo-controlled, single-dose study of the cyclooxygenase-2 inhibitor, GW406381, as a treatment for acute migraine. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18333963&form=6&db=m Sensitization of meningeal nociceptors: inhibition by naproxen. therapeutic application,unassigned 2,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18727644&form=6&db=m Differential effects of corticosteroids on the expression of cyclooxygenase-2, tumour necrosis factor-alpha and matrix metalloproteinase-9 in an animal model of migraine. ongoing research,unassigned 4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19444941&form=6&db=m Localization of COX-1 and COX-2 in the intracranial dura mater of the rat. therapeutic application,unassigned 4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357220&form=6&db=m Cox-2 gene variants in migraine. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25238714&form=6&db=m Potential effect and mechanism of action of topical chamomile (Matricaria chammomila L.) oil on migraine headache: A medical hypothesis. therapeutic application,unassigned 4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25892078&form=6&db=m Role of phosphorylated extracellular signal-regulated kinase, calcitonin gene-related peptide and cyclooxygenase-2 in experimental rat models of migraine. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26151770&form=6&db=m Exercise suppresses COX-2 pro-inflammatory pathway in vestibular migraine. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26231449&form=6&db=m Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula. unassigned -
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26861565&form=6&db=m A review on the management of migraine in the Avicenna's Canon of Medicine. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713337&form=6&db=m NSAIDs in the Acute Treatment of Migraine: A Review of Clinical and Experimental Data. therapeutic application,unassigned 3,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27757013&form=6&db=m Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine. therapeutic application,unassigned 1,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27792775&form=6&db=m Immune Modulation as an Effective Adjunct Post-exposure Therapeutic for B. pseudomallei. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28044053&form=6&db=m Plasma Levels of Cyclooxygenase-2 (COX-2) and Visfatin During Different Stages and Different Subtypes of Migraine Headaches. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053929&form=6&db=m Association of COX-2 Promoter Polymorphisms -765G/C and -1195A/G with Migraine. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28748412&form=6&db=m Pharmacokinetics of DFN-15, a Novel Oral Solution of Celecoxib, Versus Celecoxib 400-mg Capsules: A Randomized Crossover Study in Fasting Healthy Volunteers. therapeutic application,unassigned 4,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31895267&form=6&db=m Celecoxib reduces cortical spreading depression-induced macrophage activation and dilatation of dural but not pial arteries in rodents: implications for mechanism of action in terminating migraine attacks. causal interaction,unassigned 3,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32997693&form=6&db=m Association of the cyclooxygenase-2 1759A allele with migraine in Chinese Han individuals. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Migraine Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33040782&form=6&db=m Tuling Wendan Decoction combined with flunarizine in the treatment of migraine patients and the effect of intervention on serum cyclooxygenase-2, endothelin-1 and nitric oxide. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Migraine without Aura http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10961765&form=6&db=m Linked activation of nitric oxide synthase and cyclooxygenase in peripheral monocytes of asymptomatic migraine without aura patients. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Miosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2508124&form=6&db=m The putative role of prostaglandins in surgical miosis. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Miosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8229720&form=6&db=m Topical flurbiprofen in extracapsular cataract surgery: effect on pupillary diameter and iris fluorescein leakage. therapeutic application,unassigned 4,0
1.14.99.1 Mitochondrial Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22300079&form=6&db=m Small intestinal injury caused by NSAIDs/aspirin: finding new from old. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 mitogen-activated protein kinase kinase kinase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33443087&form=6&db=m MAP3K8 Regulates Cox-2-Mediated Prostaglandin E2 Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991384&form=6&db=m Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Motor Neuron Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16184763&form=6&db=m Nonsteroidal anti-inflammatory drugs differentially affect the heat shock response in cultured spinal cord cells. ongoing research,unassigned 2,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874015&form=6&db=m Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes. causal interaction,unassigned 4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11140899&form=6&db=m Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12013526&form=6&db=m The effect of betel nut extract on cell growth and prostaglandin endoperoxide synthase in human epidermoid carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12516959&form=6&db=m Deregulated cyclooxygenase-2 expression in oral premalignant tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12542827&form=6&db=m Which putatively pre-malignant oral lesions become oral cancers? Clinical relevance of early targeting of high-risk individuals. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738747&form=6&db=m The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12747975&form=6&db=m Cyclooxygenase-2 (COX-2) expression in high-risk premalignant oral lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12870656&form=6&db=m Modulation of annexin I and cyclooxygenase-2 in smokeless tobacco-induced inflammation and oral cancer. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14674624&form=6&db=m Regulation of cell growth by selective COX-2 inhibitors in oral carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014004&form=6&db=m NSAIDs for the chemoprevention of oral cancer: promise or pessimism?: Commentary re J. L. Mulshine et al., randomized, double-blind, placebo-controlled, phase IIB trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia. Clin. Cancer Res., 10: 1565-1573, 2004. therapeutic application,unassigned 4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15461861&form=6&db=m Cyclooxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756036&form=6&db=m Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15796182&form=6&db=m Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15892674&form=6&db=m The role of COX-2 in oral cancer development, and chemoprevention/ treatment of oral cancer by selective COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16719266&form=6&db=m [Oral cancer. Cyclooxygenase inhibitors for prevention: beneficial or risky] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16822500&form=6&db=m NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016639&form=6&db=m Elevated cell migration, invasion and tumorigenicity in human KB carcinoma cells transfected with COX-2 cDNA. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17354234&form=6&db=m Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17595767&form=6&db=m Butyrate inhibits oral cancer cell proliferation and regulates expression of secretory phospholipase A2-X and COX-2. therapeutic application,unassigned 1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624243&form=6&db=m Cyclooxygenase isozymes in oral squamous cell carcinoma:a real-time RT-PCR study with clinic pathological correlations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18356024&form=6&db=m Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381950&form=6&db=m Pilot randomized phase II study of celecoxib in oral premalignant lesions. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18467819&form=6&db=m Expression of cytosolic phospholipase A2 and cyclooxygenase 2 and their significance in human oral mucosae, dysplasias and squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18674950&form=6&db=m Actinic cheilitis: Epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695912&form=6&db=m Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922923&form=6&db=m Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19197984&form=6&db=m Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions. causal interaction,unassigned 4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239949&form=6&db=m Immunoexpression of cyclooxygenase-2 and p53 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19910795&form=6&db=m KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051374&form=6&db=m Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20213098&form=6&db=m Circulating cycloxygenase-2 in patients with tobacco-related intraoral squamous cell carcinoma and evaluation of its peptide inhibitors as potential antitumor agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20647315&form=6&db=m Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664981&form=6&db=m Promotion of hematogenous metastatic potentials in human KB carcinoma cells with overexpression of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20813676&form=6&db=m [High-performance liquid chromatography for determining celecoxib concentration in hamster tongue tissue after oral local application.] causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960565&form=6&db=m Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21292918&form=6&db=m Cyclooxygenase-2 Expression Is Related With Localization, Proliferation, and Overall Survival in Canine Melanocytic Neoplasms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21352962&form=6&db=m CTGF inhibits cell motility and COX-2 expression in oral cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21835258&form=6&db=m The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22290291&form=6&db=m The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-?B, MAPK, and p53 signaling. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23250779&form=6&db=m Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23394447&form=6&db=m Change in nicotine-induced VEGF, PGE2 AND COX-2 expression following COX inhibition in human oral squamous cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23658366&form=6&db=m Lactobacillus salivarius REN inhibits rat oral cancer induced by 4-nitroquioline 1-oxide. therapeutic application,unassigned 1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23790336&form=6&db=m COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25051199&form=6&db=m Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling. causal interaction,unassigned 3,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25635769&form=6&db=m Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25977924&form=6&db=m Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25984601&form=6&db=m Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464283&form=6&db=m Helioxanthin suppresses the cross talk of COX-2/PGE2 and EGFR/ERK pathway to inhibit Arecoline-induced Oral Cancer Cell (T28) proliferation and blocks tumor growth in xenografted nude mice. therapeutic application,unassigned 1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26662963&form=6&db=m Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-?B inhibition in oral cancer. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323811&form=6&db=m Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27941877&form=6&db=m Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28326700&form=6&db=m [In vitro investigation on the mechanism of cyclooxygenase-2 upregulation induced by spleen tyrosine kinase-nuclear factor ?B signaling in cancer pain caused by oral cancer-associated macrophage]. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351666&form=6&db=m Operculina turpethum extract inhibits growth and proliferation by inhibiting NF-?B, COX-2 and cyclin D1 and induces apoptosis by up regulating P53 in oral cancer cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28740192&form=6&db=m Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28790852&form=6&db=m Impact of combined treatment with nimesulide and cisplatin on oral carcinoma cells. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31448061&form=6&db=m Staphylococcus aureus induces COX-2-dependent proliferation and malignant transformation in oral keratinocytes. ongoing research,unassigned 2,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31526148&form=6&db=m Synthesis of new selective cytotoxic ricinine analogues against oral squamous cell carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32104177&form=6&db=m Antitumor Activity of Ficus deltoidea Extract on Oral Cancer: An In Vivo Study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33240646&form=6&db=m Deregulation of lysophosphatidic acid metabolism in oral cancer promotes cell migration via the up-regulation of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2
1.14.99.1 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34463097&form=6&db=m Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Moyamoya Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10559138&form=6&db=m Increase in prostaglandin E(2) production by interleukin-1beta in arterial smooth muscle cells derived from patients with moyamoya disease. ongoing research,unassigned 4,0
1.14.99.1 Moyamoya Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26503024&form=6&db=m Cyclooxygenase-2 and Prostaglandin E2 are Associated with Middle Cerebral Artery Occlusion and Hemorrhage in Patients with Moyamoya Disease. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Moyamoya Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27072959&form=6&db=m Significance of cyclooxygenase-2 elevation in middle cerebral artery for patients with hemorrhagic moyamoya disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10720537&form=6&db=m Ulinastatin, an elastase inhibitor, inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Mucocutaneous Lymph Node Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30321073&form=6&db=m The Relationship of COX-2 Gene Polymorphisms and Susceptibility to Kawasaki Disease in Chinese Population. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693241&form=6&db=m The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979925&form=6&db=m Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17046165&form=6&db=m Radiation therapy-induced mucositis: relationships between fractionated radiation, NF-kappaB, COX-1, and COX-2. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17699727&form=6&db=m A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19234862&form=6&db=m Cyclooxygenase-2 and vascular endothelial growth factor expression in 5-fluorouracil-induced oral mucositis in hamsters: evaluation of two low-intensity laser protocols. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19404685&form=6&db=m Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25531650&form=6&db=m Olmesartan decreased levels of IL-1? and TNF-?, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model. unassigned -
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25806956&form=6&db=m Correction: olmesartan decreased levels of IL-1? and TNF-?, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model. unassigned -
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28516399&form=6&db=m Hangeshashinto (TJ-14) prevents radiation-induced mucositis by suppressing cyclooxygenase-2 expression and chemotaxis of inflammatory cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29629657&form=6&db=m Advances in the Use of Anti-inflammatory Agents to Manage Chemotherapy-induced Oral and Gastrointestinal Mucositis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31746655&form=6&db=m Histological evaluation of peri-implant mucosal and gingival tissues in peri-implantitis, peri-implant mucositis and periodontitis patients: a cross-sectional clinical study. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31936203&form=6&db=m Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway. therapeutic application,unassigned 1,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32560278&form=6&db=m Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Mucositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33567307&form=6&db=m Anti-inflammatory effects of Radix Aucklandiae herbal preparation ameliorate intestinal mucositis induced by 5-fluorouracil in mice. therapeutic application,unassigned 1,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15731178&form=6&db=m Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247750&form=6&db=m Overexpression of cyclooxygenase-2 in multiple myeloma: association with reduced survival. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16847764&form=6&db=m Clinical significance of cyclooxygenase-2 (COX-2) in multiple myeloma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17222203&form=6&db=m Cyclooxygenase-2 (COX-2) in multiple myeloma: prognostic factor or therapeutic target? diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17588340&form=6&db=m Small interfering RNA of cyclooxygenase-2 induces growth inhibition and apoptosis independently of Bcl-2 in human myeloma RPMI8226 cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691115&form=6&db=m Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236756&form=6&db=m [Expressions of vascular endothelial growth factor and cyclooxygenase-2 in patients with multiple myeloma and its significance.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971811&form=6&db=m Interrelationship and expression profiling of cyclooxygenase and angiogenic factors in Indian patients with multiple myeloma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24282256&form=6&db=m Regular aspirin use and risk of multiple myeloma: a prospective analysis in the health professionals follow-up study and nurses' health study. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25070817&form=6&db=m The association between COX-2 expression and survival in myeloma patients. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30590258&form=6&db=m Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33070080&form=6&db=m Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells. ongoing research,unassigned 4,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2881471&form=6&db=m Measles virus-induced mononuclear leukocyte adherence inhibition: effect of some drugs influencing arachidonic acid metabolic pathways. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020063&form=6&db=m Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16512913&form=6&db=m COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. unassigned -
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516308&form=6&db=m The pathologic role for COX-2 in apoptotic oligodendrocytes in virus induced demyelinating disease: implications for multiple sclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17373929&form=6&db=m COX-2 promoter region polymorphisms in multiple sclerosis: lack of association of -765G>C with disease risk. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17442406&form=6&db=m COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression. therapeutic application,unassigned 2,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18085997&form=6&db=m Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537667&form=6&db=m Cyclooxygenase-2 in synaptic signaling. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20388219&form=6&db=m Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21699540&form=6&db=m The cyclooxygenase-2 pathway via the PGE(2) EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone-induced demyelination. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24095587&form=6&db=m Alterations of brain eicosanoid synthetic pathway in multiple sclerosis and in animal models of demyelination: Role of cyclooxygenase-2. unassigned -
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24349442&form=6&db=m A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation. ongoing research,unassigned 3,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328537&form=6&db=m Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30292675&form=6&db=m Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis. ongoing research,unassigned 1,0
1.14.99.1 Multiple Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32842948&form=6&db=m A Systematic Review on the Role of Arachidonic Acid Pathway in Multiple Sclerosis. therapeutic application,unassigned 4,0
1.14.99.1 Mumps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777165&form=6&db=m The Acidic Fraction of Isatidis Radix Regulates Inflammatory Response in LPS-Stimulated RAW264.7 Macrophages through MAPKs and NF-?B Pathway. therapeutic application,unassigned 1,0
1.14.99.1 Muscle Cramp http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24279689&form=6&db=m Prostanoid Receptor EP2 as a Therapeutic Target. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Muscle Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17550381&form=6&db=m Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27044361&form=6&db=m Role of Cyclooxygenase-2 in Relation to Nitric Oxide and Endothelin-1 on Pathogenesis of Cerebral Vasospasm After Subarachnoid Hemorrhage in Rabbit. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Muscle Spasticity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27738873&form=6&db=m Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice. unassigned -
1.14.99.1 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8188758&form=6&db=m Mechanical stimulation of skeletal muscle cells mitigates glucocorticoid-induced decreases in prostaglandin production and prostaglandin synthase activity. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Muscular Atrophy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33152664&form=6&db=m Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2974278&form=6&db=m Characterization of a myopathy caused by prostaglandin dysfunction. causal interaction,unassigned 1,0
1.14.99.1 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4040868&form=6&db=m Inhibition of prostaglandin synthesis produces a muscular dystrophy-like myopathy. unassigned -
1.14.99.1 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15329582&form=6&db=m Human septic myopathy: induction of cyclooxygenase, heme oxygenase and activation of the ubiquitin proteolytic pathway. ongoing research,unassigned 3,0
1.14.99.1 Muscular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778569&form=6&db=m Critical illness myopathy: what is happening? causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10222459&form=6&db=m The early induction of cyclooxygenase 2 associated with neurofibrillary degeneration in brains of patients with Fukuyama-type congenital muscular dystrophy. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21609764&form=6&db=m A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Muscular Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25320234&form=6&db=m Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. therapeutic application,unassigned 1,0
1.14.99.1 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23188550&form=6&db=m Cyclooxygenase-2 expression in skeletal muscle of knockout mice suffering Duchenne muscular dystrophy. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Muscular Dystrophy, Duchenne http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23266899&form=6&db=m Erratum to: Cyclooxygenase-2 expression in skeletal muscle of knockout mice suffering Duchenne muscular dystrophy. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Musculoskeletal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12522832&form=6&db=m Use of NSAIDs, COX-2 inhibitors, and acetaminophen and associated coprescriptions of gastroprotective agents in an elderly population. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Musculoskeletal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22943552&form=6&db=m A case of acute liver failure due to etodolac. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509060&form=6&db=m Risk of cardiovascular events associated with selective COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12659825&form=6&db=m Pharmacotherapy for regional musculoskeletal pain. therapeutic application,unassigned 4,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12798067&form=6&db=m Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15576517&form=6&db=m Comparison of valdecoxib and an oxycodone-acetaminophen combination for acute musculoskeletal pain in the emergency department: a randomized controlled trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17171384&form=6&db=m [Pain therapy with antipyretic analgesics] ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17872814&form=6&db=m Approach to managing musculoskeletal pain: acetaminophen, cyclooxygenase-2 inhibitors, or traditional NSAIDs? therapeutic application,unassigned 4,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18472996&form=6&db=m The role of tramadol in current treatment strategies for musculoskeletal pain. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19137124&form=6&db=m Celecoxib, NSAIDs and the skeleton. therapeutic application,unassigned 3,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19143855&form=6&db=m A randomised, double-blind study comparing lumiracoxib with naproxen for acute musculoskeletal pain. therapeutic application,unassigned 2,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22898213&form=6&db=m Current considerations for the management of musculoskeletal pain in Asian countries: a special focus on cyclooxygenase-2 inhibitors and non-steroid anti-inflammation drugs. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23661962&form=6&db=m Efficacy and safety of short-term use of COX-2 inhibitors in patients after an acute stroke with musculoskeletal pain. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24502626&form=6&db=m Cardiovascular risks of cyclooxygenase-2 inhibitors and traditional anti-inflammatory drugs: necessary but not sufficient for clinical decision making. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Musculoskeletal Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34042011&form=6&db=m Pain management in people with hemophilia in childhood and young adulthood. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16438751&form=6&db=m Does preoperatively administered parecoxib prevent succinylcholine-associated myalgia? A randomized, placebo-controlled trial. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507399&form=6&db=m Taxanes and COX-2 inhibitors: from molecular pathways to clinical practice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19522751&form=6&db=m A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21112698&form=6&db=m IL-6, cyclooxygenase in muscle pain. unassigned -
1.14.99.1 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759126&form=6&db=m EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29698447&form=6&db=m Celecoxib use and circulating oxylipins in a colon polyp prevention trial. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myalgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30713611&form=6&db=m Effects of intracerebroventricular injection of vitamin B12 on formalin-induced muscle pain in rats: Role of cyclooxygenase pathway and opioid receptors. ongoing research,unassigned 3,0
1.14.99.1 Mycoplasma Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23536693&form=6&db=m Mycoplasma MALP-2 induces HO-1 expression via MAPKs and Nrf2 pathways to modulate COX-2 expression in human monocytes. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26432261&form=6&db=m Sonic hedgehog-responsive lipoxygenases and cyclooxygenase-2 modulate Dectin-1-induced inflammatory cytokines. unassigned -
1.14.99.1 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28874754&form=6&db=m ROS-induced Oxidative Injury involved in Pathogenesis of Fungal Keratitis via p38 MAPK Activation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Mycoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30765301&form=6&db=m Design, synthesis and biological evaluation of amide-pyridine derivatives as novel dual-target (SE, CYP51) antifungal inhibitors. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Mycosis Fungoides http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428208&form=6&db=m COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF). causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Mycosis Fungoides http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20882047&form=6&db=m COX-2 is a novel target in therapy of mycosis fungoides. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Mycosis Fungoides http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31846957&form=6&db=m Cyclooxygenase-2 Gene Polymorphisms -765G>C and -1195A>G and Mycosis Fungoides Risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Mycosis Fungoides http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32050200&form=6&db=m Cyclooxygenase-2 Gene Polymorphisms - 765G>C and -1195A>G and Mycosis Fungoides. unassigned -
1.14.99.1 Myelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16303916&form=6&db=m Immunomodulatory effects of etanercept in an experimental model of spinal cord injury. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Myelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16601144&form=6&db=m Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Myelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17704735&form=6&db=m EFFECT OF 17beta-ESTRADIOL ON SIGNAL TRANSDUCTION PATHWAYS AND SECONDARY DAMAGE IN EXPERIMENTAL SPINAL CORD TRAUMA. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Myelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18059327&form=6&db=m Effects of zileuton and montelukast in mouse experimental spinal cord injury. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Myelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31987865&form=6&db=m Interleukin-1 receptor antagonist ameliorates the pain hypersensitivity, spinal inflammation and oxidative stress induced by systemic lipopolysaccharide in neonatal rats. therapeutic application,unassigned 1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1290295&form=6&db=m [Clinical pharmacology of acetylsalicylic acid] causal interaction,unassigned 1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1524799&form=6&db=m Cyclooxygenase products are not involved in the protection against myocardial infarction afforded by preconditioning in rabbit. Cyclooxygenase pathway's involvement in preconditioning. unassigned -
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2557848&form=6&db=m Influence of cardioprotective cyclooxygenase and lipoxygenase inhibitors on peroxidative injury to myocardial-membrane phospholipid. therapeutic application,unassigned 3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2866703&form=6&db=m Shortened megakaryocyte-platelet regeneration time in young survivors of myocardial infarction. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7661062&form=6&db=m Aspirin therapy: optimized platelet inhibition with different loading and maintenance doses. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8647575&form=6&db=m -New aspects in antithrombotic therapy--platelet inhibitors-. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10608053&form=6&db=m Platelet Activity in the Early Stage of Acute Myocardial Infarction: Relation to Time of Presentation, Treatment with Either Tissue Plasminogen Activator or Streptokinase and Cyclooxygenase Inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873679&form=6&db=m Inhibition of cyclooxygenase-2 improves cardiac function in myocardial infarction. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10963682&form=6&db=m Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits. therapeutic application,unassigned 3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11082214&form=6&db=m Nitric oxide donors. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316917&form=6&db=m Current oral antiplatelet agents to prevent atherothrombosis. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11509060&form=6&db=m Risk of cardiovascular events associated with selective COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695247&form=6&db=m NSAIDs and COX-2 inhibitors: what can we learn from large outcomes trials? The gastroenterologist's perspective. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11812159&form=6&db=m The disputed role of COX-2 in myocardial infarction, is the jury still out? unassigned -
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11812162&form=6&db=m Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11945151&form=6&db=m Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020175&form=6&db=m Selective COX-2 Inhibitors, NSAIDs, aspirin, and myocardial infarction. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12160947&form=6&db=m Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12241124&form=6&db=m Selective cyclo-oxygenase-2 inhibitors and myocardial infarction: how strong is the link? causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12456258&form=6&db=m Cyclooxygenase-2 inhibitors and myocardial infarction. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12456259&form=6&db=m Risk of myocardial infarction associated with selective COX-2 inhibitors: questions remain. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12510364&form=6&db=m [Recent development of selective cyclooxygenase-2 inhibitors] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12588209&form=6&db=m Effect of selective cyclooxygenase 2 inhibitors and naproxen on short-term risk of acute myocardial infarction in the elderly. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665969&form=6&db=m Current drug therapy for rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12710523&form=6&db=m Cyclooxygenase-2 (COX-2) in acute myocardial infarction: cellular expression and use of selective COX-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12716445&form=6&db=m COX-2: Where are we in 2003? - Be strong and resolute: continue to use COX-2 selective inhibitors at recommended dosages in appropriate patients. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730088&form=6&db=m Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy men. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12818730&form=6&db=m Role of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors, angiotensin-converting enzyme inhibitors, cyclooxygenase-2 inhibitors, and aspirin in anti-inflammatory and immunomodulatory treatment of cardiovascular diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14508588&form=6&db=m Nonsteroidal anti-inflammatory drugs in patients with cardio- or cerebrovascular disorders. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576372&form=6&db=m Cyclooxygenase-2 inhibitors: are they really atherothrombotic, and if not, why not? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14670812&form=6&db=m Inhibition of cyclooxygenase-2 improves cardiac function after myocardial infarction in the mouse. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14684373&form=6&db=m Nicorandil induces late preconditioning against myocardial infarction in conscious rabbits. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020525&form=6&db=m Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15044365&form=6&db=m Direct and indirect effects of aldosterone on cyclooxygenase-2 and interleukin-6 expression in rat cardiac cells in culture and after myocardial infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15082814&form=6&db=m Applying a research ethics committee approach to a medical practice controversy: the case of the selective COX-2 inhibitor rofecoxib. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15093759&form=6&db=m Effects of rofecoxib and naproxen on life expectancy among patients with rheumatoid arthritis: a decision analysis. therapeutic application,unassigned 1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15094969&form=6&db=m Relationship between cyclooxygenase-2 inhibition and thrombogenesis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15096449&form=6&db=m Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138244&form=6&db=m A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15684199&form=6&db=m Summaries for patients. Cyclooxygenase-2 inhibitors and heart attacks: varying effects? therapeutic application,unassigned 3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15684203&form=6&db=m Patients exposed to rofecoxib and celecoxib have different odds of nonfatal myocardial infarction. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701821&form=6&db=m The Risk for Myocardial Infarction with Cyclooxygenase-2 Inhibitors: A Population Study of Elderly Adults. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15755796&form=6&db=m Factors associated with celecoxib and rofecoxib utilization. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15780832&form=6&db=m Cardiovascular hazard and non-steroidal anti-inflammatory drugs. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809459&form=6&db=m The risk for myocardial infarction with cyclooxygenase-2 inhibitors: a population study of elderly adults. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15905461&form=6&db=m COX-2-derived prostacyclin modulates vascular remodeling. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15950485&form=6&db=m Estrogen stimulation of COX-2-derived PGI2 confers atheroprotection. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15976506&form=6&db=m Selective COX-2 inhibitors and risk of myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15990700&form=6&db=m COX-2 inhibitors and metabolism of essential fatty acids. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16038624&form=6&db=m Is COX-2 a perpetrator or a protector? Selective COX-2 inhibitors remain controversial. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16132939&form=6&db=m [Critical reevaluation of cyclooxygenase two inhibitors in perioperative pain therapy] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16190133&form=6&db=m Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16220041&form=6&db=m Cyclooxygenase-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16224510&form=6&db=m Going against the flow: the impact of PHARMAC not funding COX-2 inhibitors for chronic arthritis. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16227351&form=6&db=m COX-2 chronology. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16230734&form=6&db=m The risk for myocardial infarction with cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16230736&form=6&db=m The risk for myocardial infarction with cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16230737&form=6&db=m The risk for myocardial infarction with cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16244293&form=6&db=m Expression of COX-2 mRNA in peripheral blood monocytes from patients with acute myocardial infarction and its significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16304418&form=6&db=m The Cardiovascular Pharmacology of COX-2 Inhibition. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16370958&form=6&db=m Comparative cardiovascular safety of traditional nonsteroidal anti-inflammatory drugs. therapeutic application,unassigned 2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415488&form=6&db=m The future of traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors in the treatment of inflammation and pain. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16449211&form=6&db=m Atorvastatin reduces the expression of COX-2 mRNA in peripheral blood monocytes from patients with acute myocardial infarction and modulates the early inflammatory response. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508052&form=6&db=m Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16563251&form=6&db=m [Atorvastatin reduces the expression of COX-2 mRNA in peripheral blood monocytes in patients with acute myocardial infarction and modulates the early inflammatory response] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16586083&form=6&db=m Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16611201&form=6&db=m Non-steroidal antiinflammatory drugs and the risk of acute myocardial infarction. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16614756&form=6&db=m Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16670396&form=6&db=m Time variations in the risk of myocardial infarction among elderly users of COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16722837&form=6&db=m Increased risk of myocardial infarction as first manifestation of ischaemic heart disease and nonselective nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16728684&form=6&db=m Cyclooxygenase-2 selective nonsteroidal anti-inflammatory drugs and the risk of ischemic stroke: a nested case-control study. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16756774&form=6&db=m Role of cyclooxygenase-2 in myocardial infarction and ischaemia. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785336&form=6&db=m Risk of death or reinfarction associated with the use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflammatory drugs after acute myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16808554&form=6&db=m Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16879213&form=6&db=m Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16956424&form=6&db=m Does rofecoxib increase TNF-alpha levels? therapeutic application,unassigned 2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17086567&form=6&db=m Association between nonnaproxen NSAIDs, COX-2 inhibitors and hospitalization for acute myocardial infarction among the elderly: a retrospective cohort study. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17164137&form=6&db=m Human prostacyclin receptor structure and function from naturally-occurring and synthetic mutations. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17196469&form=6&db=m Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17210840&form=6&db=m Cyclooxygenase-2 inhibition increases mortality, enhances left ventricular remodeling, and impairs systolic function after myocardial infarction in the pig. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17222987&form=6&db=m A pathogenetic mechanism for COX-2 inhibitor-induced cardiovascular events proposed to be useful in structuring medical testimony in rofecoxib trials. therapeutic application,unassigned 3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17242292&form=6&db=m Cyclooxygenase inhibition and adverse remodeling during healing after myocardial infarction. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17244362&form=6&db=m Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17255138&form=6&db=m Risks and benefits of COX-2 inhibitors vs non-selective NSAIDs: does their cardiovascular risk exceed their gastrointestinal benefit? A retrospective cohort study. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17366315&form=6&db=m Drug-induced thrombosis--experimental, clinical, and mechanistic considerations. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17383621&form=6&db=m Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition. therapeutic application,unassigned 3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17402995&form=6&db=m Cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction and cerebrovascular accident. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437665&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17457957&form=6&db=m Risk of myocardial infarction associated with selective COX-2 inhibitors: meta-analysis of randomised controlled trials. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17555881&form=6&db=m A proposed fairer method for conducting rofecoxib trials. ongoing research,unassigned 2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785622&form=6&db=m Cardioprotection afforded by inducible nitric oxide synthase gene therapy is mediated by cyclooxygenase-2 via a nuclear factor-kappaB dependent pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786211&form=6&db=m The tell-tale heart: population-based surveillance reveals an association of rofecoxib and celecoxib with myocardial infarction. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17828456&form=6&db=m Celecoxib after the onset of reperfusion reduces apoptosis in the amygdala. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868881&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in the normal human heart and in myocardial infarction. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18158501&form=6&db=m Use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflammatory drugs in high doses increases mortality and risk of reinfarction in patients with prior myocardial infarction. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173977&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220787&form=6&db=m Computer aided drug design approaches to develop cyclooxygenase based novel anti-inflammatory and anti-cancer drugs. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18287589&form=6&db=m Cyclooxygenase-2 inhibitors and most traditional nonsteroidal anti-inflammatory drugs cause similar moderately increased risks of cardiovascular disease. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18302311&form=6&db=m Onset of acute myocardial infarction after use of non-steroidal anti-inflammatory drugs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18347209&form=6&db=m Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18373616&form=6&db=m Diabetes, colorectal cancer and cyclooxygenase 2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18405470&form=6&db=m Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18426087&form=6&db=m New aspects of cyclooxygenase-2 inhibition in myocardial infarction and ischaemia. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18473007&form=6&db=m Selective COX-2 inhibitors, NSAIDs and cardiovascular events - is celecoxib the safest choice? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695943&form=6&db=m Association of non-steroidal anti-inflammatory drugs with outcomes in patients with ST-segment elevation myocardial infarction treated with fibrinolytic therapy: an ExTRACT-TIMI 25 analysis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18787084&form=6&db=m The risk of acute myocardial infarction with etodolac is not increased compared to naproxen: a historical cohort analysis of a generic COX-2 selective inhibitor. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18931027&form=6&db=m Pioglitazone protects the myocardium against ischemia-reperfusion injury in eNOS and iNOS knockout mice. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19040046&form=6&db=m [Study on the association of cyclooxygenase-2 -765g>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China] causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19046748&form=6&db=m Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19076093&form=6&db=m [Protective effect of lornoxicam on development of myocardial infarction in rats under conditions of ischemia and ischemia-reperfusion] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19123332&form=6&db=m [Effects of propyl gallate on serum inflammatory factors and protein expression of COX-2 and ICAM-1 in ischemic myocardium of rats with acute myocardial infarction] diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19327107&form=6&db=m Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19330252&form=6&db=m Selective cyclooxygenase-2 inhibition protects against myocardial damage in experimental acute ischemia. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19413182&form=6&db=m Non-steroidal anti-inflammatory drugs and the risk of cardiovascular diseases: are we going to see the revival of cyclooxygenase-2 selective inhibitors? causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19421186&form=6&db=m Are Myocardial Infarctions and Death in Healthy Individuals Associated With the Use of Cyclooxygenase Inhibitors? causal interaction,unassigned 3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19466570&form=6&db=m Ascorbic acid prevents acute myocardial infarction induced by isoproterenol in rats: role of inducible nitric oxide synthase production. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,2
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19471752&form=6&db=m [Specific cyclooxygenase-2 inhibitor analgesics: therapeutic advances.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19528817&form=6&db=m Chronic pretreatment with celecoxib reduces infarct size. ongoing research,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19559811&form=6&db=m Comparison of microsomal prostaglandin E synthase-1 deletion and COX-2 inhibition in acute cardiac ischemia in mice. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19578513&form=6&db=m Biomarkers and Bioassays for Cardiovascular Diseases: Present and Future. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630805&form=6&db=m The translational therapeutics of prostaglandin inhibition in atherothrombosis. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19637402&form=6&db=m Non-aspirin NSAIDs, cyclooxygenase-2 inhibitors and risk for cardiovascular events-stroke, acute myocardial infarction, and death from coronary heart disease. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19641662&form=6&db=m Aspirin resistance: A fact or a myth? causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19667237&form=6&db=m Pharmacological activation of soluble guanylate cyclase protects the heart against ischemic injury. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19674639&form=6&db=m Vioxx(R): What should we tell our patients? causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19691487&form=6&db=m Prothrombotic effects of diclofenac on arteriolar platelet activation and thrombosis in vivo. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19718696&form=6&db=m The use of selective cyclooxygenase-2 inhibitors and the risk of acute myocardial infarction in Saskatchewan, Canada. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19748095&form=6&db=m Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19779026&form=6&db=m Association of myocardial infarctions with COX-2 inhibition may be related to immunomodulation towards a Th1 response resulting in atheromatous plaque instability: an evidence-based interpretation. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19804301&form=6&db=m Rosiglitazone: a disappointing DREAM. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19865081&form=6&db=m Response to "No Obvious Extra Cardiovascular Risk Associated With Low-Dose NSAIDs," "Do NSAIDs Actually Protect Against Myocardial Infarction and Death?," and "Are Myocardial Infarctions and Death in Healthy Individuals Associated With the Use of Cyclooxygenase Inhibitors?" causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19880670&form=6&db=m PKA, Rap1, ERK1/2, and p90RSK mediate PGE2 and EP4 signaling in neonatal ventricular myocytes. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917000&form=6&db=m Population impact of regulatory activity restricting prescribing of COX-2 inhibitors: ecological study. therapeutic application,unassigned 1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19967720&form=6&db=m Cyclooxygenase inhibitors: Scope of their use and development in cancer chemotherapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20000300&form=6&db=m NSAID prescribing precautions. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20059330&form=6&db=m Emotion recollected in tranquility: lessons learned from the COX-2 saga. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20170663&form=6&db=m Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20498929&form=6&db=m [Nonsteroidal anti-inflammatory drugs: cardiovascular, cerebrovascular and renal effects] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20539104&form=6&db=m Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20565461&form=6&db=m Use of non-steroidal anti-inflammatory drugs and risk of incident myocardial infarction and heart failure, and all-cause mortality in the Australian veteran community. ongoing research,unassigned 1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20569079&form=6&db=m Cardiovascular safety of non-steroidal anti-inflammatory drugs among healthy individuals. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20680998&form=6&db=m International regulatory activity restricting COX-2 inhibitor use and deaths due to gastrointestinal haemorrhage and myocardial infarction. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20938040&form=6&db=m Roles of Cyclooxygenase 2 in Sevoflurane- and Olprinone-Induced Early Phase of Preconditioning and Postconditioning Against Myocardial Infarction in Rat Hearts. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20955429&form=6&db=m Protecting against ischemia-reperfusion injury: antiplatelet drugs, statins, and their potential interactions. unassigned -
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21052013&form=6&db=m Exogenous estrogen does not attenuate the association between rofecoxib and myocardial infarction in perimenopausal women. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21256536&form=6&db=m A common promoter variant of the gene encoding cyclooxygenase-1 (PTGS1) is related to decreased incidence of myocardial infarction in patients with coronary artery disease. causal interaction,unassigned 3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21301784&form=6&db=m Residual cyclooxygenase-1 activity and epinephrine reduce the antiplatelet effect of aspirin in patients with acute myocardial infarction. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21345578&form=6&db=m Targeting apoptosis pathways by Celecoxib in cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360043&form=6&db=m Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-?-independent manner. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21371074&form=6&db=m The risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors does not vary with polymorphisms in two regions of the cyclo-oxygenase-2 gene. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22186793&form=6&db=m In Vivo Delivery of Nucleic Acids via Glycopolymer Vehicles Affords Therapeutic Infarct Size Reduction In Vivo. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22523381&form=6&db=m Muscle cyclo-oxygenase-2 pathway contributes to the exaggerated muscle mechanoreflex in rats with congestive heart failure. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22865892&form=6&db=m Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23532054&form=6&db=m COX-2 Selective Nonsteroidal Anti-inflammatory Drugs and Risk of Gastrointestinal Tract Complications and Myocardial Infarction: An Instrumental Variable Analysis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23985963&form=6&db=m Thromboxane A2 Generation, in the Absence of Platelet COX-1 Activity, in Patients With and Without Atherothrombotic Myocardial Infarction. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24467618&form=6&db=m COX-2 signaling and cancer: new players in old arena. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24570285&form=6&db=m The Role of Cyclooxygenase-1 and -2 in Sevoflurane-Induced Postconditioning Against Myocardial Infarction. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819536&form=6&db=m Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24970746&form=6&db=m PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25229174&form=6&db=m Reversible cerebral vasoconstriction syndrome possibly induced by etoricoxib. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748877&form=6&db=m Cardiovascular risks associated with non-aspirin non-steroidal anti-inflammatory drug use. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26455241&form=6&db=m Anti-platelet effects of nimesulide in isoproterenol-induced myocardial ischaemia and infarction in rabbits. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26543101&form=6&db=m Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26639722&form=6&db=m Rat paw oedema modeling and NSAIDs: Timing of effects. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26658659&form=6&db=m Variants of the Coagulation and Inflammation Genes Are Replicably Associated with Myocardial Infarction and Epistatically Interact in Russians. unassigned -
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26841787&form=6&db=m Cardiovascular Effects of Nonsteroidal Anti-inflammatory Drugs. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27526355&form=6&db=m 5-methoxytryptophan is a potential marker for post-myocardial infarction heart failure - a preliminary approach to clinical utility. causal interaction,unassigned 3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27601438&form=6&db=m Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28342204&form=6&db=m The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest and inhibits prostaglandin E2 induced proliferation in oral squamous carcinoma Tca8113 cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28347710&form=6&db=m Prostanoids in the pathophysiology of human coronary artery. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28469113&form=6&db=m A Case of Acute Myocardial Infarction Induced by Selective Cyclooxygenase-2 Inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28491485&form=6&db=m Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drugs: An Under-Recognized Public Health Issue. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28547832&form=6&db=m Response to "No Obvious Extra Cardiovascular Risk Associated With Low-Dose NSAIDs," "Do NSAIDs Actually Protect Against Myocardial Infarction and Death?," and "Are Myocardial Infarctions and Death in Healthy Individuals Associated With the Use of Cyclooxygenase Inhibitors?" causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28625237&form=6&db=m [Study on mechanisms and myocardial protective effect of Qishen Yiqi dropping pills on rats with myocardial infarction]. diagnostic usage,unassigned 1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29272017&form=6&db=m Selective cyclooxygenase-2 inhibitor NS-398 attenuates myocardial fibrosis in mice after myocardial infarction via Snail signaling pathway. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108767&form=6&db=m Structure-activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009-2016). causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30383755&form=6&db=m Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30679074&form=6&db=m MicroRNA-26b relieves inflammatory response and myocardial remodeling of mice with myocardial infarction by suppression of MAPK pathway through binding to PTGS2. therapeutic application,unassigned 3,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31208307&form=6&db=m Accelerated Atherosclerosis in Rheumatoid Arthritis: Mechanisms and Treatment. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31278427&form=6&db=m Inducible cardiac-specific overexpression of cyclooxygenase-2 (COX-2) confers resistance to ischemia/reperfusion injury. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734378&form=6&db=m Cyclooxygenase inhibition prior to ventricular fibrillation induced ischemia reperfusion injury impairs survival and outcomes. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31916080&form=6&db=m Coronary Risks Associated with Diclofenac and Other NSAIDs: An Update. causal interaction,unassigned 4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32251635&form=6&db=m Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32295420&form=6&db=m Cardiovascular Biology of Prostanoids and Drug Discovery. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540483&form=6&db=m Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115526&form=6&db=m FCER1G and PTGS2 Serve as Potential Diagnostic Biomarkers of Acute Myocardial Infarction Based on Integrated Bioinformatics Analyses. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34373695&form=6&db=m Chitosan and Curcumin Nanoformulations against Potential Cardiac Risks Associated with Hydroxyapatite Nanoparticles in Wistar Male Rats. diagnostic usage,unassigned 2,0
1.14.99.1 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34405222&form=6&db=m [Research advances of prostaglandin E2 synthases and receptors in cardiovascular diseases]. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1627331&form=6&db=m Post-ischemic rupture of the anterior papillary muscle of the right ventricle associated with persistent pulmonary hypertension of the newborn: a case report. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2509096&form=6&db=m Thromboxane is produced in response to intracoronary infusions of complement C5a in pigs. Cyclooxygenase blockade does not reduce the myocardial ischemia and leukocyte accumulation. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3130582&form=6&db=m Modulation of coronary flow rate and cardiac contractility by the divalent cation ionophore A23187 and inhibitors of the cyclooxygenase and 5-lipoxygenase pathways: development of heterogeneous patterns of myocardial ischemia. causal interaction,unassigned 4,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7048597&form=6&db=m Mediation of cardiac ischemia by thromboxanes released from human platelets. unassigned -
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7132326&form=6&db=m Platelet-mediated cardiac ischemia. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7511753&form=6&db=m Effects of acetylsalicylic acid on peripheral hemodynamics in patients with chronic heart failure treated with angiotensin-converting enzyme inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943373&form=6&db=m Effect of platelet depletion and inhibition of platelet cyclooxygenase on C5a-mediated myocardial ischemia. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679714&form=6&db=m Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11215533&form=6&db=m Serotonin-induced human coronary microvascular contraction during acute myocardial ischemia is blocked by COX-2 inhibition. causal interaction,unassigned 2,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12881220&form=6&db=m Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607463&form=6&db=m Cyclooxygenase-2 in myocardial ischemia: is it really a friend? unassigned -
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15072968&form=6&db=m Cardiac pharmacological preconditioning with volatile anesthetics: from bench to bedside? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15108964&form=6&db=m Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15302800&form=6&db=m Impact of prolonged cyclooxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised C-reactive protein: a randomized placebo-controlled study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15734901&form=6&db=m The cardioprotective effects of preconditioning with endotoxin, but not ischemia, are abolished by a peroxisome proliferator-activated receptor-gamma antagonist. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16235511&form=6&db=m Adverse interactions of rofecoxib with lisinopril in spontaneously hypertensive rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16339832&form=6&db=m Thromboxane A2-induced arrhythmias in the anesthetized rabbit. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16952493&form=6&db=m Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455055&form=6&db=m Parecoxib inhibits apoptosis in acute myocardial infarction due to permanent coronary ligation but not due to ischemia-reperfusion. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20804993&form=6&db=m Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27130642&form=6&db=m Anti-myocardial ischemia effect of Syringa pinnatifolia Hemsl. by inhibiting expression of cyclooxygenase-1 and -2 in myocardial tissues of mice. unassigned -
1.14.99.1 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34239586&form=6&db=m Uncovering the Protective Mechanism of the Volatile Oil of Acorus tatarinowii against Acute Myocardial Ischemia Injury Using Network Pharmacology and Experimental Validation. therapeutic application,unassigned 1,0
1.14.99.1 Myocardial Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9344637&form=6&db=m Effects of supplementation with iloprost on the cardioprotection by BW755C (a dual inhibitor of cyclooxygenase and lipoxygenase enzymes) in myocardial reperfusion injury. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2525319&form=6&db=m Effects of nicorandil on coronary circulation and myocardial ischemia. therapeutic application,unassigned 2,0
1.14.99.1 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2530592&form=6&db=m Effect of cyclooxygenase blockade on the beneficial actions of nicorandil in the stunned myocardium of dogs. ongoing research,unassigned 1,0
1.14.99.1 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9011643&form=6&db=m Aspirin does not prevent the attenuation of myocardial stunning by the ACE inhibitor ramiprilat. therapeutic application,unassigned 4,0
1.14.99.1 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10963682&form=6&db=m Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits. therapeutic application,unassigned 3,0
1.14.99.1 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12160947&form=6&db=m Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Myocardial Stunning http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384473&form=6&db=m Delta-opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits. unassigned -
1.14.99.1 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11679155&form=6&db=m Essential role of HIV type 1-infected and cyclooxygenase 2-activated macrophages and T cells in HIV type 1 myocarditis. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16107267&form=6&db=m Inhibition of cyclooxygenase-2 enhances myocardial damage in a mouse model of viral myocarditis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16499924&form=6&db=m A cyclooxygenase-2 inhibitor alters Th1/Th2 cytokine balance and suppresses autoimmune myocarditis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22141571&form=6&db=m Blockade of interleukin-17A protects against coxsackievirus B3-induced myocarditis by increasing COX-2/PGE2 production in the heart. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26305786&form=6&db=m Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26485277&form=6&db=m Correction: Cyclooxygenase-2 and Prostaglandin E2 Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805552&form=6&db=m MicroRNA-381 protects myocardial cell function in children and mice with viral myocarditis via targeting cyclooxygenase-2 expression. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Myocarditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30257377&form=6&db=m IL-1? reduces cardiac lymphatic muscle contraction via COX-2 and PGE2 induction: Potential role in myocarditis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Myoepithelioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11881728&form=6&db=m Increased expression of cyclooxygenase-2 in human salivary gland tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Myofascial Pain Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31693705&form=6&db=m Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Myoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19014794&form=6&db=m Effect of oral contraceptives on vascular endothelial growth factor, Cox-2 and aromatase expression in the endometrium of uteri affected by myomas and associated pathologies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,2
1.14.99.1 Myoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23690221&form=6&db=m Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Myoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23915859&form=6&db=m Bisphenol A at environmentally relevant doses induces cyclooxygenase-2 expression and promotes invasion of human mesenchymal stem cells derived from uterine myoma tissue. ongoing research,unassigned 4,0
1.14.99.1 Myoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30026090&form=6&db=m Resveratrol inhibits human leiomyoma cell proliferation via crosstalk between integrin ?v?3 and IGF-1R. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Myositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15301234&form=6&db=m The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Myositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094001&form=6&db=m Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Nasal Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10414396&form=6&db=m Expression and localization of COX-2 in human airways and cultured airway epithelial cells. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Nasal Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16579869&form=6&db=m Mechanisms of aspirin sensitivity. causal interaction,unassigned 2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9431818&form=6&db=m Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9543076&form=6&db=m Expression of cyclo-oxygenase 1 and 2 proteins in upper respiratory mucosa. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390414&form=6&db=m Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10664933&form=6&db=m Expression of cyclooxygenase in nasal polyps from atopic and nonatopic subjects. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11800371&form=6&db=m Expression of glucocorticoid receptors and cyclooxygenase-2 in nasal polyps from nonallergic patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994707&form=6&db=m Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps. causal interaction,unassigned 4,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12162776&form=6&db=m Inducible cyclooxygenase and interleukin 6 gene expressions in nasal polyp fibroblasts: possible implication in the pathogenesis of nasal polyposis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622742&form=6&db=m Nuclear factor-kappaB activity is down-regulated in nasal polyps from aspirin-sensitive asthmatics. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15301300&form=6&db=m Expression and localization of cyclooxigenases (Cox-1 and Cox-2) in nasal respiratory mucosa. Does Cox-2 play a key role in the immunology of nasal polyps? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15480320&form=6&db=m Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15794068&form=6&db=m Expression, localization, and significance of vascular permeability/vascular endothelial growth factor in nasal polyps. diagnostic usage,unassigned 3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15921208&form=6&db=m New immunohistologic findings on the differential role of cyclooxygenase 1 and cyclooxygenase 2 in nasal polyposis. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15940133&form=6&db=m Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16024204&form=6&db=m The influence of anti-inflammatory drugs on the proliferation of fibroblast derived from nasal polyps. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16517580&form=6&db=m Upregulation of COX-1 and COX-2 in nasal polyps in cystic fibrosis. ongoing research,unassigned 1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16583357&form=6&db=m Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma. causal interaction,unassigned 1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785401&form=6&db=m Expression of cyclooxygenase and lipoxygenase enzymes in nasal polyps of aspirin-sensitive and aspirin-tolerant patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016059&form=6&db=m Safety of meloxicam in aspirin-hypersensitive patients with asthma and/or nasal polyps. A challenge-proven study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17141086&form=6&db=m Expression of cyclooxygenase-2 and 5-lipoxygenase in nasal polyps associated with interleukin-4 promoter polymorphism -590. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132974&form=6&db=m Topical glucocorticoids downregulate COX-1 positive cells in nasal polyps. ongoing research,unassigned 1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19251796&form=6&db=m Glucocorticoid therapy increases COX-2 gene expression in nasal polyps in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20030038&form=6&db=m [Effect of clarithromycin on the expressions of cyclooxygenase-2 and nuclear factor-kappa B in nasal polyps in vitro] diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20403848&form=6&db=m Lipopolysaccharide induction of cyclooxygenase-2 in long-term nasal epithelial cultures in Cystic Fibrosis. ongoing research,unassigned 3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22123288&form=6&db=m Expression of Arachidonate Metabolism Enzymes and Receptors in Nasal Polyps of Aspirin-Hypersensitive Asthmatics. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22185734&form=6&db=m Cyclooxygenase 2 and lipoxin A? in nasal polyps in cystic fibrosis. unassigned -
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22416915&form=6&db=m Association of the -14C/G MET and the -765G/C COX-2 Gene Polymorphisms with the Risk of Chronic Rhinosinusitis with Nasal Polyps in a Polish Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22934333&form=6&db=m [Expressions of EOS and COX-2 in nasal polyps in patients with aspirin triad syndrome and its significance]. diagnostic usage,unassigned 1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23441755&form=6&db=m Low Prostaglandin E(2) and Cyclooxygenase Expression in Nasal Mucosa Fibroblasts of Aspirin-Intolerant Asthmatics. causal interaction,unassigned 3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23639710&form=6&db=m Mechanisms of aspirin desensitization. causal interaction,unassigned 1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24077870&form=6&db=m The effect of corticosteroid therapy on cyclooxygenase 2, vascular endothelial growth factor, and inducible nitric oxide synthase expression levels in nasal polyposis. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25573836&form=6&db=m Significance of CYCLOOXYGENASE-2(COX-2), PERIOSTIN (POSTN) and INTERLEUKIN-4(IL-4) gene expression in the pathogenesis of chronic rhinosinusitis with nasal polyps. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25590318&form=6&db=m State of the Art: Medical treatment of aspirin exacerbated respiratory disease (AERD). causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25980147&form=6&db=m [Significances of COX-2, p21, Ki-67 expression and HPV infection in nasal inverted papilloma]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26363168&form=6&db=m Autophagy is deficient and inversely correlated with COX-2 expression in nasal polyps: a novel insight into the inflammation mechanism. causal interaction,unassigned 4,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27126722&form=6&db=m Update on the Management of Aspirin-Exacerbated Respiratory Disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27712767&form=6&db=m Mechanisms of Benefit with Aspirin Therapy in Aspirin-Exacerbated Respiratory Disease. causal interaction,unassigned 2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28107149&form=6&db=m Release of cyclooxygenase-2 and lipoxin A4 from blood leukocytes in aspirin-exacerbated respiratory disease. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28124651&form=6&db=m Aspirin-exacerbated respiratory disease: Prevalence, diagnosis, treatment, and considerations for the future. diagnostic usage,unassigned 2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28286156&form=6&db=m Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400178&form=6&db=m Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review. causal interaction,unassigned 4,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29336282&form=6&db=m Role of group 2 innate lymphocytes in aspirin-exacerbated respiratory disease pathogenesis. causal interaction,unassigned 4,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30479022&form=6&db=m Increased expression of L-plastin in nasal polyp of patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease. causal interaction,unassigned 3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30582489&form=6&db=m Clinical updates in aspirin-exacerbated respiratory disease. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847401&form=6&db=m Computed Tomography Findings in Patients with Samter's Triad: An Observational Study. causal interaction,unassigned 3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31889962&form=6&db=m Expression of COX-1, COX-2, 5-LOX and
CysLT
2
in nasal polyps and bronchial tissue of patients with aspirin exacerbated airway disease. unassigned -
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32208749&form=6&db=m Symptom Control of Patients With Chronic Rhinosinusitis With Nasal Polyps Under Maintenance Therapy With Daily Acetylsalicylic Acid. therapeutic application,unassigned 2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32371071&form=6&db=m Activation of the 15-lipoxygenase pathway in aspirin-exacerbated respiratory disease. causal interaction,unassigned 3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343991&form=6&db=m COX-2 Overexpression in Schneiderian Papillomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33467191&form=6&db=m Expression of Transcript Variants of PTGS1 and PTGS2 Genes among Patients with Chronic Rhinosinusitis with Nasal Polyps. diagnostic usage,unassigned 2,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33819512&form=6&db=m Studies of the role of basophils in aspirin-exacerbated respiratory disease pathogenesis. causal interaction,unassigned 3,0
1.14.99.1 Nasal Polyps http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34091656&form=6&db=m Mucin 5AC is significantly upregulated in exosomes from the nasal lavage fluid and may promote the expression of COX-2, VEGF and MMP-9: an implication in nasal polyp pathogenesis. causal interaction,unassigned 2,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11381123&form=6&db=m Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15210070&form=6&db=m Effects of cyclooxygenase 2 inhibitors on biological traits of nasopharyngeal carcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723947&form=6&db=m Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15858127&form=6&db=m Cyclooxygenase 2 expression in nasopharyngeal carcinoma: immunohistochemical findings and potential implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054423&form=6&db=m Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273277&form=6&db=m Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507390&form=6&db=m Celecoxib induces dose dependent growth inhibition in nasopharyngeal carcinoma cell lines independent of cyclooxygenase-2 expression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892492&form=6&db=m Retraction to "Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with lymph node metastasis" [Oral Oncol. 41 (2005) 903-908]. diagnostic usage,unassigned 3,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17208308&form=6&db=m Immunohistochemical expression of epidermal growth factor receptor and cyclooxygenase-2 in pediatric nasopharyngeal carcinomas: no significant correlations with clinicopathological variables and treatment outcomes. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17536451&form=6&db=m [The value of cyclooxygenase-2 to predict the effect of radiotherapy in nasopharyngeal carcinoma] diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17968676&form=6&db=m PTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18061524&form=6&db=m Overexpression of COX-2 and LMP1 are correlated with lymph node in Tunisian NPC patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758376&form=6&db=m The clinical significance of coexpression of cyclooxygenases-2, vascular endothelial growth factors, and epidermal growth factor receptor in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18950008&form=6&db=m [Expressions of COX-2 and MMP-2 in nasopharyngeal carcinoma and the their relationship with lymph node metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19452725&form=6&db=m [The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma] diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19591688&form=6&db=m Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data from randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01). causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19726335&form=6&db=m [Silencing of COX-2 in nasopharyngeal carcinoma cells with a shRNAmir lentivirus vector] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20429385&form=6&db=m [Expression and relationship of EBV LMP1, COX-2 and VEGF-C in nasopharyngeal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20809260&form=6&db=m Anti-cancer effects of celecoxib on nasopharyngeal carcinoma HNE-1 cells expressing COX-2 oncoprotein. ongoing research,unassigned 4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21031415&form=6&db=m Prognostic significance of expression of vegf and cox-2 in nasopharyngeal carcinoma and its association with expression of C-erbB2 and EGFR. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21199607&form=6&db=m Correlations between expression of epidermal growth factor receptor (EGFR), phosphorylated EGFR, cyclooxygenase-2 and clinicopathological variables and treatment outcomes in nasopharyngeal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215211&form=6&db=m [Influence of celecoxib on invasiveness of human high-metastatic nasopharyngeal carcinoma cell line CNE-2Z]. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21515451&form=6&db=m [Effect of shRNAmir lentiviral vector-mediated COX-2 silencing on the radiosensitivity of nasopharyngeal carcinoma cells]. ongoing research,unassigned 4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21708478&form=6&db=m Phase I clinical trial of nasopharyngeal radiotherapy and concurrent celecoxib for patients with locoregionally advanced nasopharyngeal carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22803408&form=6&db=m [Expression and correlation of cyclooxygenase-2 and vascular endothelial growth factor in nasopharyngeal carcinoma-]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22972415&form=6&db=m Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23174742&form=6&db=m Three concerns with regards to the utilization of COX-2 inhibitor (celecoxib) in combination with standard chemoradiotherapy for nasopharyngeal carcinoma. therapeutic application,unassigned 3,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23375645&form=6&db=m Aberrant expression of ?-catenin and E-cadherin is correlated with poor prognosis of nasopharyngeal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24640603&form=6&db=m Cyclooxygenase-2 inhibitor celecoxib suppresses invasion and migration of nasopharyngeal carcinoma cell lines through a decrease in matrix metalloproteinase-2 and -9 activity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25060857&form=6&db=m Overexpression of Wild-Type p53-Induced Phosphatase 1 Confers Poor Prognosis of Patients with Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25142993&form=6&db=m [Relationship between cyclooxygenase-2 in nasopharyngeal carcinoma and cervical lymph node metastasis]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25333664&form=6&db=m Effusanin E suppresses nasopharyngeal carcinoma cell growth by inhibiting NF-?B and COX-2 signaling. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25438689&form=6&db=m The CC-genotype of the cyclooxygenase-2 gene associates with decreased risk of nasopharyngeal carcinoma in a Tunisian population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25553117&form=6&db=m Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-?B/COX-2 pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25669978&form=6&db=m Activating enhancer-binding protein-2? induces cyclooxygenase-2 thus promoting nasopharyngeal carcinoma growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261650&form=6&db=m Association between 8473T>C polymorphism in the cyclooxygenase-2 gene and the risk of nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26451317&form=6&db=m COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26547585&form=6&db=m Quantitative measurement of iNOS expression in melanoma, nasopharyngeal, colorectal, and breast tumors of Tunisian patients: comparative study and clinical significance. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27765529&form=6&db=m Identification of key genes involved in nasopharyngeal carcinoma. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27998871&form=6&db=m [Expressions of cyclooxygenase-2 and basic fibroblast growth factor in nasopharyngeal carcinoma and their association with radiotherapy sensitivity]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28301518&form=6&db=m Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28435473&form=6&db=m Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1. diagnostic usage,unassigned 3,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29956730&form=6&db=m High COX-2 expression contributes to a poor prognosis through the inhibition of chemotherapy-induced senescence in nasopharyngeal carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30038488&form=6&db=m Radiosensitivity enhancement by combined treatment of nimotuzumab and celecoxib on nasopharyngeal carcinoma cells. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082142&form=6&db=m The prognostic value of COX-2 expression on circulating tumor cells in nasopharyngeal carcinoma: A prospective analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087034&form=6&db=m The association between COX-2 gene rs5275 polymorphism and Nasopharyngeal carcinoma risk. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30314699&form=6&db=m lncRNA HOTAIR upregulates COX-2 expression to promote invasion and migration of nasopharyngeal carcinoma by interacting with miR-101. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559850&form=6&db=m Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31298328&form=6&db=m Correlation between COX-2 gene polymorphism and susceptibility to nasopharyngeal carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31486495&form=6&db=m Clinical significance of circulating tumor cells and their expression of cyclooxygenase-2 in patients with nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31867776&form=6&db=m High COX-2 expression in cancer-associated fibiroblasts contributes to poor survival and promotes migration and invasiveness in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32595725&form=6&db=m Study on the Drug Targets and Molecular Mechanisms of Rhizoma Curcumae in the Treatment of Nasopharyngeal Carcinoma Based on Network Pharmacology. therapeutic application,unassigned 1,0
1.14.99.1 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33277861&form=6&db=m Relationship between cyclooxygenase-2 (COX-2) content and prognosis in nasopharyngeal carcinoma before and after radiochemotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Nasopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723947&form=6&db=m Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Nasopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15772955&form=6&db=m Prediction of poor survival by cyclooxygenase-2 in patients with T4 nasopharyngeal cancer treated by radiation therapy: clinical and in vitro studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Nasopharyngeal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20396543&form=6&db=m Expression of Cyclooxygenase (COX)-2 as a Prognostic Factor in Nasopharyngeal Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Nematode Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32484881&form=6&db=m Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2. ongoing research,unassigned 1,0
1.14.99.1 Neonatal Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12660439&form=6&db=m T-cell proliferative responses following sepsis in neonatal rats. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasm Invasiveness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22000259&form=6&db=m [Analysis of HIF-1? and COX-2 expression in tumor stroma and correlation with the degree of neoplasm invasiveness in laryngeal cancer--preliminary study]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1841624&form=6&db=m Participation of macrophages in the mechanism mediating the enhancement of metastasis formation after tumour resection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2503244&form=6&db=m Linoleic acid metabolism in metastatic and nonmetastatic murine mammary tumor cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3917850&form=6&db=m Inhibition of human malignant neuroblastoma cell DNA synthesis by lipoxygenase metabolites of arachidonic acid. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137463&form=6&db=m Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapies. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8771566&form=6&db=m Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9383784&form=6&db=m Effects of dietary menhaden oil, soy, and a cyclooxygenase inhibitor on human breast cancer cell growth and metastasis in nude mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9589912&form=6&db=m Chemopreventive effects of NSAIDs against colorectal cancer: regulation of apoptosis and mitosis by COX-1 and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731479&form=6&db=m Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9809985&form=6&db=m Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9824628&form=6&db=m Influence of dietary linoleic acid on experimental human breast cancer cell metastasis in athymic nude mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022645&form=6&db=m Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353732&form=6&db=m Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398082&form=6&db=m Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10404093&form=6&db=m Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517428&form=6&db=m The relationship between cyclooxygenase-2 expression and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10604722&form=6&db=m Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10684704&form=6&db=m High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10917546&form=6&db=m Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10919714&form=6&db=m Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10931458&form=6&db=m Expression of cyclooxygenase-2 in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11091570&form=6&db=m Dietary Fat, Fatty Acids and Breast Cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11122864&form=6&db=m Advances in cancer pain management. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11139815&form=6&db=m Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156216&form=6&db=m Expression of metastases-associated genes in cervical cancers resected in the proliferative and secretory phases of the menstrual cycle. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11176123&form=6&db=m Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11206834&form=6&db=m Cyclooxygenase-2 expression in colorectal cancer liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11241241&form=6&db=m Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11275997&form=6&db=m Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309214&form=6&db=m Advances in cancer pain management. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309334&form=6&db=m Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11326316&form=6&db=m Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342898&form=6&db=m Expression of cyclooxygenase-2 in patients with bladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350912&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389100&form=6&db=m Transcriptional silencing of Cyclooxygenase-2 by hyper-methylation of the 5' CpG island in human gastric carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11442675&form=6&db=m Induction of apoptosis by cyclooxygenase-2 inhibitors in prostate cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11443626&form=6&db=m Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11464289&form=6&db=m Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460-LNM35 suggest mimicry of inflammatory cells in metastasis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566494&form=6&db=m Expression of nitric oxide synthase, cyclooxygenase, and p53 in different stages of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11601879&form=6&db=m Nonsteroidal anti-inflammatory drugs for treatment of advanced gastric cancer: cyclooxygenase-2 is involved in hepatocyte growth factor mediated tumor development and progression. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11701743&form=6&db=m Increased expression of cyclooxygenase-2 in malignant pheochromocytomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729113&form=6&db=m Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779086&form=6&db=m Approach to angiogenesis inhibition based on cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786771&form=6&db=m Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819707&form=6&db=m Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection, histological types and staging. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830509&form=6&db=m Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830510&form=6&db=m Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11888937&form=6&db=m Cyclooxygenase-2 activity altered the cell-surface carbohydrate antigens on colon cancer cells and enhanced liver metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891209&form=6&db=m Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920595&form=6&db=m Expression of cyclooxygenase-2 in the subserosal layer correlates with postsurgical prognosis of pathological tumor stage 2 carcinoma of the gallbladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11965228&form=6&db=m Celecoxib: a specific COX-2 inhibitor with anticancer properties. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11981761&form=6&db=m Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11993714&form=6&db=m Antidepressants, eicosanoids and the prevention and treatment of cancer. A review. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12003384&form=6&db=m Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009007&form=6&db=m Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12037025&form=6&db=m Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12051953&form=6&db=m Characterization of cyclooxygenase-2 (COX-2) during tumorigenesis in human epithelial cancers: evidence for potential clinical utility of COX-2 inhibitors in epithelial cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12055587&form=6&db=m Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066205&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086404&form=6&db=m Increased expression of COX-2 in the development of human lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124799&form=6&db=m Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164968&form=6&db=m Role of cyclooxygenase-2 and inducible nitric oxide synthase in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12168930&form=6&db=m COX-2 expression in rectal carcinoma: immunohistochemical pattern and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12192599&form=6&db=m Exposure of human breast cancer cells to the anti-inflammatory agent indomethacin alters choline phospholipid metabolites and Nm23 expression. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196922&form=6&db=m Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203806&form=6&db=m Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209745&form=6&db=m Overexpression of cyclooxygenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12405290&form=6&db=m Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12408376&form=6&db=m Cyclooxygenase inhibitors block cell growth, increase ceramide and inhibit cell cycle. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12408753&form=6&db=m Expression of inflammation related enzymes during experimental rat lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432918&form=6&db=m Cyclooxygenases and colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434411&form=6&db=m Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452059&form=6&db=m [A study on cyclooxygenase-2 protein expression and vasculature during experimental rat lung carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452062&form=6&db=m [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12455057&form=6&db=m Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488433&form=6&db=m The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504031&form=6&db=m High cyclooxygenase-2 expression is related with distant metastasis in cervical cancer treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12553373&form=6&db=m Effects of Celebrex and Zyflo on liver metastasis and lipidperoxidation in pancreatic cancer in Syrian hamsters. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12566300&form=6&db=m Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12592098&form=6&db=m Cyclooxygenase-2 expression is associated with well-differentiated and intestinal-type pathways in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622426&form=6&db=m Expression of cyclooxygenase-2 protein in colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631609&form=6&db=m Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12667327&form=6&db=m [Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679908&form=6&db=m Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12680220&form=6&db=m The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727848&form=6&db=m Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738729&form=6&db=m Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767510&form=6&db=m Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767532&form=6&db=m Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12783255&form=6&db=m Role of cyclooxygenase-2 in the angiogenesis of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12800231&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12802790&form=6&db=m Cyclooxygenase-2 inhibitors in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12814542&form=6&db=m Role of COX-2 specific inhibitors in oncogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821346&form=6&db=m Expression of cyclooxygenase-1 and -2 associated with expression of VEGF in primary cervical cancer and at metastatic lymph nodes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12854133&form=6&db=m Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883661&form=6&db=m Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883688&form=6&db=m Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949718&form=6&db=m The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957358&form=6&db=m Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958148&form=6&db=m IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963227&form=6&db=m Clinicopathologic significance of cyclooxygenase-2 overexpression in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530048&form=6&db=m Lung cancer and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534699&form=6&db=m Cyclooxygenase-2 expression in lymph node metastasis of cervical and vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14550281&form=6&db=m Aberrant methylation of the specific CpG island portion regulates cyclooxygenase-2 gene expression in human gastric carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566258&form=6&db=m Cyclooxygenase-2 inhibition decreases primary and metastatic tumor burden in a murine model of orthotopic lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14574941&form=6&db=m [Combined treatment with fluorinated pyrimidines and selective cyclooxygenase-2 inhibitors for liver metastasis of colon cancer] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14598890&form=6&db=m Suppression by nimesulide of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607721&form=6&db=m Expression of cyclooxygenase-1 and -2 in extra-hepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14616542&form=6&db=m Cyclooxygenase-2 and gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14640057&form=6&db=m [Cyclooxygenase(COX)-2-inhibition in the prevention and treatment of colorectal carcinoma] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654921&form=6&db=m Combined treatment with selective cyclooxygenase-2 inhibitor and fluorinated pyrimidines for liver metastasis of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654968&form=6&db=m Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681319&form=6&db=m Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688483&form=6&db=m Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716842&form=6&db=m Expression of COX-2 proteins in gastric mucosal lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719154&form=6&db=m Overexpression of cyclooxygenase-2 correlates with chromosomal gain at the cyclooxygenase-2 locus and decreased patient survival in advanced colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14754878&form=6&db=m COX-2 gene promoter haplotypes and prostate cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760389&form=6&db=m Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871981&form=6&db=m Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14989896&form=6&db=m [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991639&form=6&db=m Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15023244&form=6&db=m Prognostic impact of cyclooxygenase-2 in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15025797&form=6&db=m Cyclooxygenase-2 expression in right- and left-sided colon cancer: a rationale for optimization of cyclooxygenase-2 inhibitor therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075004&form=6&db=m Expression of cyclooxygenase-1 and -2 and clinicopathologic features of colorectal cancer in northern Thailand. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15086604&form=6&db=m Expression of cyclooxygenase-2 in cholangiocarcinoma: correlation with clinicopathological features and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151619&form=6&db=m Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162003&form=6&db=m Cyclo-oxygenase 2 expression in laryngeal squamous cell carcinoma and its clinical correlates. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15170663&form=6&db=m Reduction of tumor progression and paraneoplastic syndrome development in murine lung adenocarcinoma by nonsteroidal antiinflammatory drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179621&form=6&db=m The role of COX-2 inhibition in breast cancer treatment and prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15213717&form=6&db=m Antimetastatic activity of a cyclooxygenase-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222024&form=6&db=m Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222037&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222049&form=6&db=m Anti-cancer effects of COX-2 inhibitors and their correlation with angiogenesis and invasion in gastric cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15230726&form=6&db=m Cyclo-oxygenase-2 expression in esophageal adenocarcinoma as a determinant of clinical outcome following esophagectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272284&form=6&db=m COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15283156&form=6&db=m [Overexpression of COX-2 and a potential clinical application of its inhibitors in lung cancer] causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289320&form=6&db=m Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15309515&form=6&db=m Prevention of colorectal cancer through the use of COX-2 selective inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15322087&form=6&db=m Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15325613&form=6&db=m NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15330183&form=6&db=m Elevated cyclooxygenase-2 expression correlates with distant metastases in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332534&form=6&db=m [COX and study of cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15342458&form=6&db=m Cyclooxygenase-2 and p53 expressions in endometrial cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15353307&form=6&db=m Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15363351&form=6&db=m [Relationship of cyclooxygenase 2 expression and chemotherapy response and prognosis in human ovarian carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386343&form=6&db=m JTE-522, a selective COX-2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: a vascular cast model study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15461861&form=6&db=m Cyclooxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466184&form=6&db=m Oncogenic action of secreted phospholipase A2 in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15472909&form=6&db=m Selective inhibition of cyclooxygenase (COX)-2 inhibits endothelial cell proliferation by induction of cell cycle arrest. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15473933&form=6&db=m [Effect of cyclooxygenase-2,and matrix metalloproteinase-2 expression on prognosis of lung cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476855&form=6&db=m Nitric oxide signaling in colon cancer chemoprevention. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15484698&form=6&db=m Cyclooxygenase-2 in oligodendroglioma: possible prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501972&form=6&db=m Concomitant overexpression of cyclooxygenase-2 in HER-2-positive on Smad4-reduced human gastric carcinomas is associated with a poor patient outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15554390&form=6&db=m Control of pulmonary metastases of rat mammary cancer by inhibition of uPA and COX-2, singly and in combination. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15570054&form=6&db=m Vitamin E and breast cancer. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623626&form=6&db=m Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15671526&form=6&db=m Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685827&form=6&db=m Celecoxib and radiation therapy in non-small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15704107&form=6&db=m Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723653&form=6&db=m Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15726508&form=6&db=m Cyclooxygenase-2 inhibition in colorectal cancer: boom or bust? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743541&form=6&db=m JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15744816&form=6&db=m Cyclooxygenase-2 and p53 expression as prognostic indicators in conventional renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15746067&form=6&db=m Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754389&form=6&db=m Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754411&form=6&db=m Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756426&form=6&db=m Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15772955&form=6&db=m Prediction of poor survival by cyclooxygenase-2 in patients with T4 nasopharyngeal cancer treated by radiation therapy: clinical and in vitro studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809733&form=6&db=m COX-2 overexpression increases motility and invasion of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816526&form=6&db=m The effect of cyclooxygenase-2 (COX-2) inhibition on human prostate cancer induced osteoblastic and osteolytic lesions in bone. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856454&form=6&db=m Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868166&form=6&db=m Combination therapy using the cyclooxygenase-2 inhibitor Parecoxib and radioimmunotherapy in nude mice with small peritoneal metastases of colonic origin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870865&form=6&db=m Cox-2 and Her2/neu co-expression in invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15942563&form=6&db=m Evaluation of cyclooxygenase-2 inhibition in an orthotopic murine model of lung cancer for dose-dependent effect. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947945&form=6&db=m Cyclooxygenase-2 in normal, hyperplastic and neoplastic follicular cells of the human thyroid gland. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963122&form=6&db=m The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15968728&form=6&db=m Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054423&form=6&db=m Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080553&form=6&db=m Cyclooxygenase-2 expression in brain metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16097070&form=6&db=m Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16099602&form=6&db=m Increased expression of nitric oxide synthase and cyclooxygenase-2 is associated with poor survival in cervical cancer treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111807&form=6&db=m Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16124396&form=6&db=m Role of COX-2 selective inhibitors for prevention and treatment of cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16164044&form=6&db=m Prognostic importance of COX-2 expression in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167259&form=6&db=m [Relationship between cyclooxygenase- 2 expression and angiogenesis in patients with gastric cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167260&form=6&db=m [COX- 2 expression in gastric cancer and its relationship with lymphangiogenesis and lymph node metastasis] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16182442&form=6&db=m Oncogenic action of phospholipase A2 in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16199309&form=6&db=m Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204019&form=6&db=m A functional role for hemostasis in early cancer development. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243430&form=6&db=m Effects of COX-2 inhibitor on growth of human gastric cancer cells and its relation to hepatocyte growth factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243823&form=6&db=m Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16246405&form=6&db=m Prevalence and prognostic significance of COX-2 expression in stage IB cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16255988&form=6&db=m [Roles of cyclooxygenase-2 and caspase-3 expression in pathogenesis of lung carcinoma: an experiment with rats] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16260857&form=6&db=m Overexpression of cyclooxygenase-2 in gastric cancer correlates with the high abundance of vascular endothelial growth factor-C and lymphatic metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273249&form=6&db=m Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head and neck cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16285555&form=6&db=m [Relationship between the expression of cyclooxygenase-2 and microvessel density in oral squamnous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16293616&form=6&db=m Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16302726&form=6&db=m Multiple roles of cyclooxygenase-2 in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309227&form=6&db=m Cox-2 levels in canine mammary tumors, including inflammatory mammary carcinoma: clinicopathological features and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314343&form=6&db=m Expression of cyclooxygenase-2 and matrix metalloproteinase-9 in gastric carcinoma and its correlation with angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16324362&form=6&db=m [Correlation between Stat3 signal transduction pathway and expression of cyclooxygenase-2 in colorectal cancer cells] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16343055&form=6&db=m Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16361154&form=6&db=m [Expression of COX-2 protein in colorectal carcinoma and the clinical implication] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391837&form=6&db=m Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409625&form=6&db=m The selective Cox-2 inhibitor Celecoxib suppresses angiogenesis and growth of secondary bone tumors: an intravital microscopy study in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16420789&form=6&db=m [Cyclooxygenase-2 expression as a prognostic factor in sporadic colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16432453&form=6&db=m Expression of cyclooxygenase-2 in benign naevi and during human cutaneous melanoma progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16448745&form=6&db=m A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16457848&form=6&db=m COX-2 induces IL-11 production in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16467169&form=6&db=m Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474989&form=6&db=m Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16483484&form=6&db=m [Expression of vascular endothelial growth factor C and cyclooxygenase-2 in non-small-cell lung carcinoma and their clinical significance.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489006&form=6&db=m Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489098&form=6&db=m The Cyclooxygenase-2 (PTGS2) 8473T>C Polymorphism is Associated with Breast Cancer Risk. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16494037&form=6&db=m [The expressiong of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507389&form=6&db=m Aberrant methylation of cyclooxygenase-2 in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507394&form=6&db=m Cyclooxygenase-2 expression is associated with VEGF-C and lymph node metastases in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507397&form=6&db=m Study of COX-2, Ki67, and p53 expression to predict effectiveness of 5-flurouracil, epirubicin and cyclophosphamide with celecoxib treatment in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16528365&form=6&db=m Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550738&form=6&db=m Inducible cyclooxygenase (COX-2) in glioblastoma--clinical and immunohistochemical (COX-2-VEGF) correlations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16556483&form=6&db=m Quantitative analysis of aromatase, sulfatase and 17beta-HSD(1) mRNA expression in soft tissue metastases of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627914&form=6&db=m Cyclooxygenase-2 and thromboxane synthase in non-endocrine and endocrine tumors: a review. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16678856&form=6&db=m Involvement of IL-8 in COX-2-mediated bone metastases from breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707460&form=6&db=m Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16711020&form=6&db=m Expression of vascular endothelial growth factor and cyclooxygenase-2 in laryngeal squamous cell carcinoma and its significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16718274&form=6&db=m Complete and long-lasting regression of disseminated multiple skin melanoma metastases under treatment with cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16720448&form=6&db=m Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16724673&form=6&db=m Cutaneous and intra-abdominal abscess formation in rats following radio frequency [corrected] ablation of liver tumors in combination with celecoxib treatment. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731602&form=6&db=m MMP-2 but not MMP-9 associated with COX-2 and survival in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16766770&form=6&db=m Antiangiogenic activity of the selective cyclooxygenase 2 inhibitor rofecoxib in human colorectal cancer liver metastases. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16788159&form=6&db=m Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16831226&form=6&db=m Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16837203&form=6&db=m Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872316&form=6&db=m Expression of cyclo-oxygenase-2 in gastrointestinal carcinoid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872953&form=6&db=m Perioperative cyclooxygenase 2 inhibition to reduce tumor cell adhesion and metastatic potential of circulating tumor cells in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16888001&form=6&db=m Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900533&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16916756&form=6&db=m More than structural cells, fibroblasts create and orchestrate the tumor microenvironment. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16938519&form=6&db=m The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16967149&form=6&db=m [Cox-2 and CD105 expression in breast cancer and disease-free survival.] diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984531&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996907&form=6&db=m Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17021746&form=6&db=m Different matrix micro-environments in colon cancer and diverticular disease. unassigned -
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030351&form=6&db=m COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062337&form=6&db=m [Association of abnormal cyclooxygenase-2 gene expression with colorectal carcinoma metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17073683&form=6&db=m Imaging of cyclooxygenase-2 (COX-2) expression: potential use in diagnosis and drug evaluation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17109196&form=6&db=m Immunohistochemical measurement of endothelial cell apoptosis and proliferation in formalin-fixed, paraffin-embedded human cancer tissue. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17118848&form=6&db=m Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17142201&form=6&db=m Prognostic factors and COX-2 expression in advanced stage esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17147116&form=6&db=m [Flow cytometric quantitative analysis of multiple tumor suppressor gene 1 (MTS1) and cyclooxygenase-2 (COX-2) gene expressions in invasive breast cancers and their clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201140&form=6&db=m COX-2 inhibitor celecoxib suppresses tumor growth and lung metastasis of a murine mammary cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201169&form=6&db=m Anticancer potential of silymarin: from bench to bed side. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17213821&form=6&db=m COX-2 involvement in breast cancer metastasis to bone. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17278192&form=6&db=m Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291249&form=6&db=m Cyclooxygenase-2 expression in cervical intraepithelial neoplasia III and squamous cell cervical carcinoma, and its correlation with clinicopathologic variables. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17296438&form=6&db=m Expression of cyclooxygenase-2 in normal urothelium, and superficial and advanced transitional cell carcinoma of bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17313803&form=6&db=m [The inhibitive effects of celecoxib combined with octreotide on the metastasis of human gastric cancer in vivo] diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332916&form=6&db=m Cyclooxygenase-2 uses the protein kinase C/ interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363183&form=6&db=m Antidepressants, prostaglandins and the prevention and treatment of cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17381414&form=6&db=m Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384145&form=6&db=m EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403293&form=6&db=m [Evaluation of cyclooxygenase-2 in the prediction of liver metastasis of colorectal carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404023&form=6&db=m The cyclooxygenase-2 selective inhibitor celecoxib suppresses proliferation and invasiveness in the human oral squamous carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413988&form=6&db=m Identification of potential prognostic markers for vulvar cancer using immunohistochemical staining of tissue microarrays. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17427971&form=6&db=m Prognostic significance of cyclooxygenase-2 and DNA topoisomerase IIalpha expression in oral carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429393&form=6&db=m Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17510310&form=6&db=m Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525632&form=6&db=m Cyclooxygenase-2 (COX-2) overexpression in meningiomas: real time PCR and immunohistochemistry. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17549374&form=6&db=m VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17563460&form=6&db=m Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581404&form=6&db=m Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584158&form=6&db=m Back to the future: COX-2 inhibitors for chemoprevention and cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17592230&form=6&db=m Tumor size significantly correlates with postoperative liver metastases and COX-2 expression in patients with resectable pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17608853&form=6&db=m Involvement of cyclooxygenase-2 and vascular endothelial growth factor in vascularization and lymph node metastasis of colorectal cancers with submucosal invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612047&form=6&db=m Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17659693&form=6&db=m COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarray. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17672932&form=6&db=m [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17697546&form=6&db=m [Correlation of cyclooxygenase-2 expression to P-glycoprotein expression in B-cell non-Hodgkin's lymphoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17721268&form=6&db=m COX-2 expression in invasive breast cancer: correlation with prognostic parameters and outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17762961&form=6&db=m 5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17763971&form=6&db=m Cyclooxygenases, prostanoids, and tumor progression. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17846040&form=6&db=m Correlations between cyclooxygenase-2 expression and angiogenic factors in primary tumors and liver metastases in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17877615&form=6&db=m Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17881290&form=6&db=m COX-2 expression predicts prostate-cancer outcome: analysis of data from the RTOG 92-02 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17916073&form=6&db=m Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy: evidence for a Bcl-2-dependent mechanism. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919838&form=6&db=m Cyclooxygenase-2 expression as a predictor of para-aortic lymph node recurrence in uterine cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934334&form=6&db=m Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17942462&form=6&db=m The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17956162&form=6&db=m Clinical, histopathological, and molecular characteristics of papillary thyroid microcarcinoma. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17968676&form=6&db=m PTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971769&form=6&db=m COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974958&form=6&db=m Inhibition of Cyclooxygenase-2 Suppresses Lymph Node Metastasis via Reduction of Lymphangiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18032824&form=6&db=m EGF-R is expressed and AP-1 and NF-kappaB are activated in stromal myofibroblasts surrounding colon adenocarcinomas paralleling expression of COX-2 and VEGF. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18061524&form=6&db=m Overexpression of COX-2 and LMP1 are correlated with lymph node in Tunisian NPC patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18062281&form=6&db=m [The expression and significance of HIF-1alpha and COX-2 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18068001&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor-C correlates with lymphangiogenesis and lymphatic invasion in human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18069634&form=6&db=m [Expression of COX-2 and MMP-9 in cervical carcinoma and their clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18090132&form=6&db=m 15-Lipoxygenase-2 is differentially expressed in normal and neoplastic ovary. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159174&form=6&db=m [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174234&form=6&db=m Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18181047&form=6&db=m Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18190720&form=6&db=m Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18228100&form=6&db=m Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18247029&form=6&db=m Celecoxib inhibits growth of tumors in a syngeneic rat liver metastases model for colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18250037&form=6&db=m [Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18262731&form=6&db=m Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288396&form=6&db=m Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18301460&form=6&db=m Cyclooxygenase-2 expression in chronic gastritis and gastric carcinoma, correlation with prognostic parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18319253&form=6&db=m Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18320840&form=6&db=m Role of cyclooxygenase-2 in tumor progression and immune regulation in lung cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18353631&form=6&db=m Morphological features and molecular markers in rectal cancer from 95 patients included in the European Organisation for Research and Treatment of Cancer 22921 trial: prognostic value and effects of preoperative radio (chemo) therapy. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18356024&form=6&db=m Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18362501&form=6&db=m Cyclooxygenase-2 expression in human thyroid disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18386173&form=6&db=m Programmed cell death 4 inhibits breast cancer cell invasion by increasing tissue inhibitor of metalloproteinases-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18398660&form=6&db=m Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18443952&form=6&db=m Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18449376&form=6&db=m Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462866&form=6&db=m Curcumin and cancer: an "old-age" disease with an "age-old" solution. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18507001&form=6&db=m Combination therapy of S-1 with selective cyclooxygenase-2 inhibitor for liver metastasis of colorectal carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566569&form=6&db=m Genes controlling spread of breast cancer to lung "gang of 4". causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577844&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses the growth of pancreatic cancer cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18592138&form=6&db=m shRNA-targeted Cyclooxygenase (COX)-2 inhibits proliferation, reduces invasion and enhances chemosensitivity in laryngeal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18594470&form=6&db=m Cyclooxygenase-2 expression in primary and metastatic Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18663571&form=6&db=m Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18671849&form=6&db=m Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691115&form=6&db=m Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18705402&form=6&db=m Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18725385&form=6&db=m Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758643&form=6&db=m Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18797196&form=6&db=m COX-2 expression correlates with survival in patients with osteosarcoma lung metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18800677&form=6&db=m [The expression of COX-2 mRNA and protein in human laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18842581&form=6&db=m Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18926952&form=6&db=m Anti-metastatic Action of Non-steroidal Anti-inflammatory Drugs. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18950008&form=6&db=m [Expressions of COX-2 and MMP-2 in nasopharyngeal carcinoma and the their relationship with lymph node metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952368&form=6&db=m Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3. causal interaction,unassigned 2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18953425&form=6&db=m The malignant phenotype of breast cancer cells is reduced by COX-2 silencing. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18977022&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the uterine cervix is associated with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19000324&form=6&db=m Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098866&form=6&db=m Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19102503&form=6&db=m [Expressions of MMP-2 and COX-2 mRNA in bladder transitional cell carcinoma and their correlation] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116363&form=6&db=m Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116446&form=6&db=m Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138835&form=6&db=m A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19189639&form=6&db=m Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203768&form=6&db=m COX-2 expression in canine normal and neoplastic mammary gland. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236238&form=6&db=m Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260469&form=6&db=m Coexpression of cyclooxygenase-2 and vascular endothelial growth factor in gastrointestinal stromal tumor: possible relations to pathological parameters and clinical behavior. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280060&form=6&db=m Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19282568&form=6&db=m Survival effects of cyclooxygenase-2 and 12-lipooxygenase in Egyptian women with operable breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287974&form=6&db=m Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19300368&form=6&db=m Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in Oral Squamous Cell Carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19307990&form=6&db=m The immune tolerance of cancer is mediated by IDO that is inhibited by COX-2 inhibitors through regulatory T cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19326179&form=6&db=m Cyclooxygenase-2 Overexpression Predicts Poor Survival in Patients with High-grade Extremity Osteosarcoma: A Pilot Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19348044&form=6&db=m Can licorice lick colon cancer? causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19390242&form=6&db=m Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19391129&form=6&db=m COX-2 is induced by HGF stimulation in Met-positive thyroid papillary carcinoma cells and is involved in tumour invasiveness. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430402&form=6&db=m COX-2 expression in malignant melanoma: a novel prognostic marker? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19432844&form=6&db=m Cyclo-oxygenase-2 expression in photon-radiated and non-radiated uveal melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19443354&form=6&db=m A randomized controlled trial investigating the effects of celecoxib in patients with localized prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19490624&form=6&db=m Corticotropin Releasing Factor promotes breast cancer cell motility and invasiveness. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19491271&form=6&db=m Loss of retinal cadherin facilitates mammary tumor progression and metastasis. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509584&form=6&db=m Assessment of promising protein markers for vulva cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19608016&form=6&db=m Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19618291&form=6&db=m Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-kappaB in prostate cancer cells. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680997&form=6&db=m Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19684042&form=6&db=m Multicenter Phase II Trial of Combination Therapy with Meloxicam, a COX-2 Inhibitor, and Natural Interferon-{alpha} for Metastatic Renal Cell Carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19685508&form=6&db=m Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via VEGF-C. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19730383&form=6&db=m The relationship between HPV16 and expression of cyclooxygenase-2, P53 and their prognostic roles in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19751908&form=6&db=m Predictive value of cyclooxygenase 2 and Bcl-2 for cervical lymph node metastasis in mucoepidermoid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759193&form=6&db=m Selenium modifies the osteoblast inflammatory stress response to bone metastatic breast cancer. unassigned -
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19799610&form=6&db=m Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19816074&form=6&db=m The relationship between cyclooxygenase-2, CD44v6, and nm23H1 in esophageal squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19821125&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19836060&form=6&db=m Prognostic relevance of cyclooxygenase-2 (COX-2) expression in Chinese patients with prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19837676&form=6&db=m Regulation of transforming growth factor-{beta}-dependent cyclooxygenase-2 expression in fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19846662&form=6&db=m MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887544&form=6&db=m Experimental cancer therapy using restoration of NAD+ -linked 15-hydroxyprostaglandin dehydrogenase expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19897661&form=6&db=m PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19909744&form=6&db=m Antimetastatic role of Smad4 signaling in colorectal cancer. ongoing research,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19922946&form=6&db=m Triptolide Inhibits Proliferation and Migration of Colon Cancer Cells by Inhibition of Cell Cycle Regulators and Cytokine Receptors. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19933077&form=6&db=m Reduced risk of bone metastasis for patients with breast cancer who use COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19939424&form=6&db=m The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19940363&form=6&db=m Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956498&form=6&db=m Expression of Cyclooxygenase-2 in Human Breast Cancer: Relationship with HER-2/neu and other Clinicopathological Prognostic Factors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004562&form=6&db=m Hypertonic environment elicits cyclooxygenase-2-driven prostaglandin E2 generation by colon cancer cells: role of cytosolic phospholipase A2-alpha and kinase signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20019776&form=6&db=m [Expression and function of cyclooxygenase-2 in endometrial carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20021866&form=6&db=m [Expression of COX-2 and VEGF and their correlation with angiogenesis in human clear cell renal cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032377&form=6&db=m Expression of the CD117, COX-2 and HSP90 antigens and cell proliferation in fine-needle-aspirated cells from metastatic melanomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20033868&form=6&db=m The Licorice Flavonoid Isoliquiritigenin Suppresses Phorbol Ester-induced Cyclooxygenase-2 Expression in the Non-tumorigenic MCF-10A Breast Cell Line. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20035770&form=6&db=m Prostaglandin E2 upregulates survivin expression via the EP1 receptor in hepatocellular carcinoma cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20046424&form=6&db=m Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20062571&form=6&db=m Inhibitory Effect of IFN-beta, on the Antitumor Activity of Celecoxib in U87 Glioma Model. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20068092&form=6&db=m Identification of cyclooxygenase-2 as a major actor of the transcriptomic adaptation of endothelial and tumor cells to cyclic hypoxia: effect on angiogenesis and metastases. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20120873&form=6&db=m [Expression of COX-2 and VEGF-C in papillary thyroid carcinoma and their relationship to cervical lymph metastases] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124103&form=6&db=m Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20132963&form=6&db=m Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20178602&form=6&db=m Cyclooxygenase-2 enhances alpha2beta1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192574&form=6&db=m Cyclooxygenase-2 Expression in Cervical Squamous Cell Carcinoma: the Significance of Expression in Neoplastic Cells within the Lymphovascular Space. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20201783&form=6&db=m Flavonoids of the Genus Iris (Iridaceae). unassigned -
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20202090&form=6&db=m Celecoxib enhances the inhibitory effect of cisplatin on Tca8113 cells in human tongue squamous cell carcinoma in vivo and in vitro. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20213098&form=6&db=m Circulating cycloxygenase-2 in patients with tobacco-related intraoral squamous cell carcinoma and evaluation of its peptide inhibitors as potential antitumor agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226002&form=6&db=m Molecular basis of traditional Chinese medicine in cancer chemoprevention. unassigned -
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20359903&form=6&db=m Aspirin and non-small cell lung cancer resections: effect on long-term survival. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20396543&form=6&db=m Expression of Cyclooxygenase (COX)-2 as a Prognostic Factor in Nasopharyngeal Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20399617&form=6&db=m TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20409773&form=6&db=m COX-2 is overexpressed in primary prostate cancer with metastatic potential and may predict survival. A comparison study between COX-2, TGF-beta, IL-10 and Ki67. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428812&form=6&db=m Potential of molecular targeted therapy of HER-2 and Cox-2 for invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446020&form=6&db=m 17beta-Estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20462604&form=6&db=m Role of COX-2 in Tumorospheres Derived from a Breast Cancer Cell Line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20477063&form=6&db=m Eicosanoids in inflammation and cancer: the role of COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20513002&form=6&db=m Colon carcinoma cell interaction with liver sinusoidal endothelium inhibits organ-specific antitumor immunity through interleukin-1-induced mannose receptor in mice. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20514441&form=6&db=m Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582552&form=6&db=m Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635052&form=6&db=m [Expression of NF-kappaB and COX-2 in tongue squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20647315&form=6&db=m Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651346&form=6&db=m COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664981&form=6&db=m Promotion of hematogenous metastatic potentials in human KB carcinoma cells with overexpression of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20673501&form=6&db=m [Detection of EGFR and COX-2 expression by immunohistochemical method on a tissue microarray section in lung cancer and biological significance] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20683050&form=6&db=m Prognostic evaluation of COX-2 expression in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20691996&form=6&db=m Overexpression of COX-2 in celecoxib-resistant breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20709621&form=6&db=m Inhibitive effect of celecoxib on the adhesion and invasion of human tongue squamous carcinoma cells to extracellular matrix via down regulation of MMP-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716424&form=6&db=m [The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20824502&form=6&db=m The Expression of Both Peroxisome Proliferator-Activated Receptor Delta and Cyclooxygenase-2 in Tissues Is Associated with Poor Prognosis in Colorectal Cancer Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20830783&form=6&db=m COX-2-mediated regulation of VEGF-C in association with lymphangiogenesis and lymph node metastasis in lung cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20842125&form=6&db=m Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878062&form=6&db=m Mechanisms behind COX-1 and COX-2 inhibition of tumor growth in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20944117&form=6&db=m Cytoplasmic phospholipase A2 metabolites play a critical role in pulmonary tumor metastasis in mice. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960565&form=6&db=m Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20961430&form=6&db=m Abalone visceral extract inhibit tumor growth and metastasis by modulating Cox-2 levels and CD8+ T cell activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20974686&form=6&db=m Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E2 and prostaglandin E2 receptors. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042835&form=6&db=m Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21044318&form=6&db=m Increasing CD44+/CD24- tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069452&form=6&db=m Nuclear co-localization and functional interaction of COX-2 and HIF-1? characterize bone metastasis of human breast carcinoma. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069476&form=6&db=m COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21114937&form=6&db=m [Prognostic value of survivin and cyclooxygenase-2 expression in non-small cell lung cancer: a tissue microarray analysis.] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118643&form=6&db=m [Suppression of COX-2 protein to cell apoptosis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118647&form=6&db=m [Correlation of time-density curve of CT enhancement with angiogenesis in lung cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21138631&form=6&db=m [The expression of hepatitis B virus X protein and cyclooxygenase-2 in hepatitis B virus-related hepatocellular carcinoma: correlation with microangiogenesis and metastasis, and what is the possible mechanism]. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21145881&form=6&db=m Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves ?v?5 integrin, ILK and AP-1-dependent pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21153458&form=6&db=m Methylation status and overexpression of COX-2 in Tunisian patients with ductal invasive breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205525&form=6&db=m [Effects of cyclooxygenase-2 antisense vector on proliferation and sensitivity to cisplatin of H1299 cells.] causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215004&form=6&db=m [Expression of COX-2 and its prognostic significance in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21225228&form=6&db=m Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21234531&form=6&db=m Celecoxib enhances radiation response of secondary bone tumors of a human non-small cell lung cancer via antiangiogenesis in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21238650&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses metastatic disease without affecting primary tumor growth in a murine model of Ewing sarcoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21262157&form=6&db=m [Cyclooxygenase-2, inducible nitric oxide synthase protein expression and vasculature during experimental rat lung carcinogenesis.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21292918&form=6&db=m Cyclooxygenase-2 Expression Is Related With Localization, Proliferation, and Overall Survival in Canine Melanocytic Neoplasms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21320400&form=6&db=m [Cyclooxygenase-2 expression in female pulmonary adenocarcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21352962&form=6&db=m CTGF inhibits cell motility and COX-2 expression in oral cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21412163&form=6&db=m Cyclooxygenase-2 Is an Independent Predictor of Poor Prognosis in Uterine Leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21419457&form=6&db=m Predictive Factors for Malignant Pheochromocytoma: Analysis of 136 Patients. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443099&form=6&db=m Expression of COX-2, survivin in regional lymph node metastases of gastric carcinoma and the correlation with prognosis. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479487&form=6&db=m Cyclooxygenase-2 expression in invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21600223&form=6&db=m COX-2 expression is correlated with VEGF-C, lymphangiogenesis and lymph node metastasis in human cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21699021&form=6&db=m Inhibition of invasion and experimental metastasis of murine melanoma cells by Ipomoea obscura (L.) is mediated through the down-regulation of inflammatory mediators and matrix-metalloproteinases. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21732411&form=6&db=m Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21761157&form=6&db=m Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813027&form=6&db=m Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21830126&form=6&db=m Cycloxygenase-2 is Essential for the Survival and Proliferation of Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21840784&form=6&db=m Cyclooxygenase-2 immunoexpression in breast cancer: Progesterone receptor influence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21867538&form=6&db=m Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21924350&form=6&db=m Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21934214&form=6&db=m Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: a pilot study. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21953546&form=6&db=m Noninvasive imaging identifies new roles for cyclooxygenase-2 in choline and lipid metabolism of human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21978392&form=6&db=m Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21981137&form=6&db=m Multifaceted link between cancer and inflammation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002714&form=6&db=m Prostaglandin E2 EP receptors as therapeutic targets in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022384&form=6&db=m Green tea catechins reduce invasive potential of human melanoma cells by targeting COX-2, PGE2 receptors and epithelial-to-mesenchymal transition. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22025079&form=6&db=m The metastatic microenvironment: Brain-residing melanoma metastasis and dormant micrometastasis. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22088344&form=6&db=m The impact of cyclooxygenase-2 and vascular endothelial growth factor C immunoexpression on the prognosis of penile carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22344367&form=6&db=m Inhibition of cyclooxygenase-2 by tetramethylpyrazine and its effects on A549 cell invasion and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22353218&form=6&db=m Immunohistochemical expression of epithelial and stromal immunomodulatory signalling molecules is a prognostic indicator in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22371637&form=6&db=m Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22372762&form=6&db=m Prognostic value of apoptotic markers in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22389271&form=6&db=m Correlation between Spiral CT Preoperative Staging of Pancreatic Cancer and PTEN and COX-2 Expression. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22406826&form=6&db=m Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer. unassigned -
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460857&form=6&db=m Epithelial to mesenchymal transition in cutaneous squamous cell carcinoma is correlated with COX-2 expression but not with the presence of stromal macrophages or CD10-expressing cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22546756&form=6&db=m Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22549391&form=6&db=m Tumor interstitial fluid and gastric cancer metastasis: an experimental study to verify the hypothesis of "tumor-phlegm microenvironment". ongoing research,unassigned 2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22641101&form=6&db=m Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22703797&form=6&db=m Celecoxib inhibits invasion and metastasis via a cyclooxygenase 2-independent mechanism in an in vitro model of Ewing sarcoma. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22710400&form=6&db=m The establishment of supramolecular immunobead real-time PCR and the identification of Cox-2 as a metastasis-related marker in colorectal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22718198&form=6&db=m Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735610&form=6&db=m Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22751903&form=6&db=m Antitumor and anti-metastatic effects of cyclooxygenase-2 inhibition by celecoxib on human colorectal carcinoma xenografts in nude mouse rectum. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22828609&form=6&db=m Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22866112&form=6&db=m A review of the anti-tumor effect of the combined administration of a cyclooxygenase-2 selective inhibitor and a non-specific immunostimulant protein-bound polysaccharide on an advanced colon cancer model using colon cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23011604&form=6&db=m Protein predictive signatures for lymph node metastasis of gastric cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23029485&form=6&db=m Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23033540&form=6&db=m The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23052170&form=6&db=m Heterogeneity of COX-2 and multidrug resistance between primary tumors and regional lymph node metastases of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23172668&form=6&db=m Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23260331&form=6&db=m Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23285691&form=6&db=m Impact of celecoxib on soluble intercellular adhesion molecule-1 and soluble e-cadherin concentrations in human colon cancer cell line cultures exposed to phytic acid and TNF-alpha. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23372950&form=6&db=m Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23375645&form=6&db=m Aberrant expression of ?-catenin and E-cadherin is correlated with poor prognosis of nasopharyngeal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23482441&form=6&db=m A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520664&form=6&db=m Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23527044&form=6&db=m Prognostic Significance of COX-2 Immunohistochemical Expression in Colorectal Cancer: A Meta-Analysis of the Literature. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23617728&form=6&db=m Papillary Carcinoma of the Thyroid: High Expression of COX-2 and Low Expression of KAI-1/CD82 Are Associated with Increased Tumor Invasiveness. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23667623&form=6&db=m Cyclooxygenase-2 inhibition blocks M2 macrophage differentiation and suppresses metastasis in murine breast cancer model. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23670240&form=6&db=m COX-2 regulates E-cadherin expression through the NF-?B/Snail signaling pathway in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23673480&form=6&db=m Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675067&form=6&db=m Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23809761&form=6&db=m Cyclo-oxygenase-2 expression is associated with vascular endothelial growth factor C expression and lymph node metastasis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23857285&form=6&db=m Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23922175&form=6&db=m Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23936870&form=6&db=m 11?-Hydroxysteroid Dehydrogenase Type II is a Potential Target for Prevention of Colorectal Tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973710&form=6&db=m miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23997259&form=6&db=m Doxorubicin and deracoxib adjuvant therapy for canine splenic hemangiosarcoma: A pilot study. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24000661&form=6&db=m [Coxibs for postoperative analgesia]. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24002607&form=6&db=m Pre-irradiation of mouse mammary gland stimulates cancer cell migration and development of lung metastases. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019861&form=6&db=m Expression of COX-2, CD44v6 and CD147 and Relationship with Invasion and Lymph Node Metastasis in Hypopharyngeal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24025354&form=6&db=m Targeting ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24060154&form=6&db=m Concurrent Expression of Cyclo-oxygenase-2 and Epidermal Growth Factor Receptor in Canine Malignant Mammary Tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24065532&form=6&db=m Starfish polysaccharides downregulate metastatic activity through the MAPK signaling pathway in MCF-7 human breast cancer cells. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127882&form=6&db=m Cyclooxygenase-2 inhibitor suppresses tumour progression of prostate cancer bone metastases in nude mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24213116&form=6&db=m The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24291175&form=6&db=m Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24331369&form=6&db=m Aspirin reduces lung cancer metastasis to regional lymph nodes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24390421&form=6&db=m Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade : Phytoblockers of metastasis cascade. unassigned -
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24420741&form=6&db=m Expression of angiogenic factors is increased in metastasised renal cell carcinomas. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24467618&form=6&db=m COX-2 signaling and cancer: new players in old arena. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24533777&form=6&db=m The Role of Anti-LeY Antibody in the Downregulation of MAPKs/COX-2 Pathway in Gastric Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24560404&form=6&db=m Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-c and lymph node metastasis in human oral tongue cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24640098&form=6&db=m Expression of molecular markers in low-grade chondrosarcomas and cartilaginous tumors with uncertain differentiation. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649093&form=6&db=m Effect of celecoxib plus standard chemotherapy on serum levels of vascular endothelial growth factor and cyclooxygenase-2 in patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24666548&form=6&db=m The impact of COX-2 on invasion of osteosarcoma cell and its mechanism of regulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24669166&form=6&db=m Role of Cyclooxygenase 2 (COX-2) in Prognosis of Breast Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24683330&form=6&db=m Anesthetic Techniques and Cancer Recurrence after Surgery. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24704993&form=6&db=m MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24716145&form=6&db=m Silibinin and Paclitaxel Cotreatment Significantly Suppress the Activity and Lung Metastasis of Triple Negative 4T1 Mammary Tumor Cell in Mice. ongoing research,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24787377&form=6&db=m Inflammation induced by human papillomavirus in cervical cancer and its implication in prevention. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24859418&form=6&db=m COX2 expression in neuroblastoma increases tumorigenicity but does not affect cell death in response to the COX2 inhibitor celecoxib. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24859472&form=6&db=m Metastatic potential in MDA-MB-231 human breast cancer cells is inhibited by proton beam irradiation via the Akt/nuclear factor-?B signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922641&form=6&db=m Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24964992&form=6&db=m COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24981602&form=6&db=m Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24983372&form=6&db=m Epidermal growth factor receptor (EGFR) and prostaglandin-endoperoxide synthase 2 (PTGS2) are prognostic biomarkers for patients with resected colorectal cancer liver metastases. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24992958&form=6&db=m Cyclooxygenase-2 inhibition as a strategy for treating gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25024195&form=6&db=m Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054056&form=6&db=m Cyclooxygenase-2 expression in non-metastatic triple-negative breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25060715&form=6&db=m Association of promoter polymorphism -765G>C in the PTGS2 gene with malignant melanoma in Italian patients and its correlation to gene expression in dermal fibroblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25060857&form=6&db=m Overexpression of Wild-Type p53-Induced Phosphatase 1 Confers Poor Prognosis of Patients with Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25094029&form=6&db=m Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25102875&form=6&db=m [Expression and clinical significance of Cox-2 and XIAP in malignant tumors of the salivary gland]. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25119169&form=6&db=m Ductal adenocarcinoma of the pancreas usually retained SMAD4 and p53 protein status as well as expression of epithelial-to-mesenchymal transition markers and cell cycle regulators at the stage of liver metastasis. ongoing research,unassigned 2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25133423&form=6&db=m Inflammatory lymphangiogenesis in postpartum breast tissue remodeling. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25133426&form=6&db=m Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25137041&form=6&db=m Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25142993&form=6&db=m [Relationship between cyclooxygenase-2 in nasopharyngeal carcinoma and cervical lymph node metastasis]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202381&form=6&db=m Effect of cycloxygenase-2 silencing on the malignant biological behavior of MCF-7 breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25242400&form=6&db=m Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25248616&form=6&db=m INPP4B suppresses prostate cancer cell invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25252849&form=6&db=m Hu-antigen receptor (HuR) and cyclooxygenase-2 (COX-2) expression in human non-small-cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25271626&form=6&db=m Prostanoid induces premetastatic niche in regional lymph nodes. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25302170&form=6&db=m Cyclooxygenase-2 and the inflammogenesis of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25333935&form=6&db=m Vascular endothelial growth factor plays a critical role in the formation of the pre-metastatic niche via prostaglandin E2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337538&form=6&db=m Cyclooxygenase-1 and -2: molecular targets for cervical neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25381814&form=6&db=m STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483152&form=6&db=m miR-26b is downregulated in human tongue squamous cell carcinoma and regulates cell proliferation and metastasis through a COX-2-dependent mechanism. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25494807&form=6&db=m Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25553436&form=6&db=m Curcumin as an Adjuvant to Breast Cancer Treatment. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595899&form=6&db=m Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25625242&form=6&db=m Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25691572&form=6&db=m Roles of the cyclooxygenase 2-matrix metalloproteinase 1 pathway in brain metastasis of breast cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25704623&form=6&db=m Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798255&form=6&db=m Smoking-induced changes in cancer-related factors in patients with upper tract urothelial cancer. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25888998&form=6&db=m Cyclooxygenase-2 expression is a prognostic biomarker for non-small cell lung cancer patients treated with adjuvant platinum-based chemotherapy. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25949900&form=6&db=m Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against ?? T cell cytotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25962348&form=6&db=m Cyclooxygenase-2 - An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973014&form=6&db=m Nephroblastoma overexpressed gene (NOV) enhances RCC cell motility through upregulation of ICAM-1 and COX-2 expression via Akt pathway. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26034355&form=6&db=m Expression of COX-2 and HER-2 in colorectal cancer and their correlation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26067757&form=6&db=m Pro-migratory actions of the prostacyclin receptor in human breast cancer cells that over-express cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26101475&form=6&db=m Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26131278&form=6&db=m Expression of matrix metalloproteinase-9, cyclooxygenase-2 and vascular endothelial growth factor are increased in gastrointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26180515&form=6&db=m Cyclooxygeanse-2 promotes metastasis in osteosarcoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26193871&form=6&db=m New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26257064&form=6&db=m Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26257474&form=6&db=m Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261008&form=6&db=m Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26323923&form=6&db=m Expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in Chinese patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26423666&form=6&db=m Expression and Significance of COX-2 and Ki-67 in Hepatolithiasis with Bile Duct Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26426828&form=6&db=m Thyroid Cancer and Nonsteroidal Anti-Inflammatory Drug Use: A Pooled Analysis of Patients Older Than 40 Years of Age. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26451317&form=6&db=m COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26460079&form=6&db=m Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26476537&form=6&db=m P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26483874&form=6&db=m Role of retinoids in the prevention and treatment of colorectal cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26497206&form=6&db=m A prognostic classifier for patients with colorectal cancer liver metastasis, based on AURKA, PTGS2 and MMP9. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498465&form=6&db=m Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26530254&form=6&db=m A novel aspirin prodrug inhibits NF?B activity and breast cancer stem cell properties. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26547585&form=6&db=m Quantitative measurement of iNOS expression in melanoma, nasopharyngeal, colorectal, and breast tumors of Tunisian patients: comparative study and clinical significance. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26561056&form=6&db=m Guggulsterone for Chemoprevention of Cancer. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26595378&form=6&db=m Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26597177&form=6&db=m Anti-tumor enhancement of Fei-Liu-Ping ointment in combination with celecoxib via cyclooxygenase-2-mediated lung metastatic inflammatory microenvironment in Lewis lung carcinoma xenograft mouse model. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622726&form=6&db=m Paclitaxel combined with harmine inhibits the migration and invasion of gastric cancer cells through downregulation of cyclooxygenase-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622766&form=6&db=m Cyclooxygenase-2 gene polymorphisms and the risk of colorectal cancer: A population-based study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680798&form=6&db=m Expression of Cyclooxygenase-2 in Human Breast Carcinoma: Relevance to Tumor Angiogenesis and Expression of Estrogen Receptor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26770028&form=6&db=m Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26777972&form=6&db=m Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26791964&form=6&db=m Clinical relevance of cyclo-oxygenase 2 and peroxisome proliferator activated receptor ? in eyelid sebaceous gland carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807319&form=6&db=m Association of EP2 receptor and SLC19A3 in regulating breast cancer metastasis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870269&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and interleukin-32 in primary gastric B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26909300&form=6&db=m The SK-N-AS human neuroblastoma cell line develops osteolytic bone metastases with increased angiogenesis and COX-2 expression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26920155&form=6&db=m Cyclooxygenase 2 (rs2745557) Polymorphism and the Susceptibility to Benign Prostate Hyperplasia and Prostate Cancer in Egyptians. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959737&form=6&db=m MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26984380&form=6&db=m Regulation of COX-2 expression and epithelial-to-mesenchymal transition by hypoxia-inducible factor-1? is associated with poor prognosis in hepatocellular carcinoma patients post TACE surgery. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27057636&form=6&db=m Sp1 and COX2 expression is positively correlated with a poor prognosis in pancreatic ductal adenocarcinoma. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27074574&form=6&db=m Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27109804&form=6&db=m Meloxicam suppresses hepatocellular carcinoma cell proliferation and migration by targeting COX-2/PGE2-regulated activation of the ?-catenin signaling pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145282&form=6&db=m Inhibition of cancer cell epithelial mesenchymal transition by normal fibroblasts via production of 5-methoxytryptophan. ongoing research,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27170832&form=6&db=m Characterisation of the triple negative breast cancer phenotype associated with the development of central nervous system metastases. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27176787&form=6&db=m Suppressive effects of a proton beam on tumor growth and lung metastasis through the inhibition of metastatic gene expression in 4T1 orthotopic breast cancer model. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27186121&form=6&db=m Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27198692&form=6&db=m Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27234549&form=6&db=m HER-2, EGFR, Cox-2 and Ki67 expression in lymph node metastasis of canine mammary carcinomas: Association with clinical-pathological parameters and overall survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314294&form=6&db=m Clinical and prognosis relevance of COX-2 expression in Tunisian patients with primary gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314329&form=6&db=m Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323811&form=6&db=m Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27349331&form=6&db=m Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27377703&form=6&db=m Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27391144&form=6&db=m Intratumoral expression of cyclooxygenase-2 (COX-2) is a negative prognostic marker for patients with cutaneous melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27420617&form=6&db=m [The connection of miR-21 and miR-155 with regulation of 15-HPGDH mRNA in human breast cancer cells]. causal interaction,unassigned 2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27447568&form=6&db=m Disruption of tumour-host communication by downregulation of LFA-1 reduces COX-2 and e-NOS expression and inhibits brain metastasis growth. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27457107&form=6&db=m Prognostic significance of expression of cysteine-rich 61 and cyclooxygenase-2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27494851&form=6&db=m Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27554763&form=6&db=m Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27578604&form=6&db=m Retrospective evaluation of COX-2 expression, histological and clinical factors as prognostic indicators in dogs with renal cell carcinomas undergoing nephrectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27697529&form=6&db=m Cox-2 promotes mesenchymal stem cells differentiation into cardiocytes by activating JNK and ERK pathway. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27852824&form=6&db=m Differential Receptor Binding and Regulatory Mechanisms for the Lymphangiogenic Growth Factors Vascular Endothelial Growth Factor (VEGF)-C and -D. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895738&form=6&db=m Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27967239&form=6&db=m Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27991924&form=6&db=m Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27999206&form=6&db=m Clinicopathological and prognostic significance of COX-2 immunohistochemical expression in breast cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28029661&form=6&db=m Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28152501&form=6&db=m Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28231855&form=6&db=m COX-2 expression positively correlates with PD-L1 expression in human melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272681&form=6&db=m Correlation of COX- 2 Expression in Colorectal Carcinoma with Clinicopathological Features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28301518&form=6&db=m Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28352075&form=6&db=m Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic Cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28368394&form=6&db=m Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386327&form=6&db=m Reduction of COX-2 through modulating miR-124/SPHK1 axis contributes to the antimetastatic effect of alpinumisoflavone in melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28393249&form=6&db=m EpCAM and COX?2 expression are positively correlated in human breast cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28413655&form=6&db=m Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449470&form=6&db=m Impact of cyclooxygenase-2 and prostaglandin-E2 expression on clinical outcome after pulmonary metastasectomy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28467670&form=6&db=m High COX-2 expression in canine mast cell tumours is associated with proliferation, angiogenesis and decreased overall survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474124&form=6&db=m Expressions and clinical significance of COX-2, VEGF-C, and EFGR in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489236&form=6&db=m Histologic correlation of VEGF and COX-2 expression with tumor size in squamous cell carcinoma of the larynx and hypopharynx. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28490464&form=6&db=m Perioperative COX-2 and ?-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521457&form=6&db=m Expression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28652771&form=6&db=m The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28724634&form=6&db=m Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28740192&form=6&db=m Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28865485&form=6&db=m Combination therapy of PKC? and COX-2 inhibitors synergistically suppress melanoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927045&form=6&db=m Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28964785&form=6&db=m CXCR2 promotes breast cancer metastasis and chemoresistance via suppression of AKT1 and activation of COX2. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29131381&form=6&db=m Long non-coding RNA cox-2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152086&form=6&db=m COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29201696&form=6&db=m Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29289998&form=6&db=m Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29335811&form=6&db=m Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29461280&form=6&db=m The rationale for a role for diet and nutrition in the prevention and treatment of cancer. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29492204&form=6&db=m Stromal versus tumoral inflammation differentially contribute to metastasis and poor survival in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29587668&form=6&db=m Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29596308&form=6&db=m EP4 as a Therapeutic Target for Aggressive Human Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29700305&form=6&db=m The therapeutic effect of miR-125b is enhanced by the prostaglandin endoperoxide synthase 2/cyclooxygenase 2 blockade and hampers ETS1 in the context of the microenvironment of bone metastasis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29767863&form=6&db=m Influence of VEGF, COX-2, and MMP-9 expression on the molybdenum-targeted X-ray in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805673&form=6&db=m Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29923556&form=6&db=m Regulating the Golgi apparatus by co-delivery of a COX-2 inhibitor and Brefeldin A for suppression of tumor metastasis. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29932878&form=6&db=m COX-2 inhibition by celecoxib in epithelial ovarian cancer attenuates E-cadherin suppression through reduced Snail nuclear translocation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003735&form=6&db=m Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30079321&form=6&db=m Quantitative analysis of COX-2 promoter methylation in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082142&form=6&db=m The prognostic value of COX-2 expression on circulating tumor cells in nasopharyngeal carcinoma: A prospective analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30083255&form=6&db=m Suspension state promotes metastasis of breast cancer cells by up-regulating cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087797&form=6&db=m Evaluation of Cytotoxicity Effects of Chalcone Epoxide Analogues as a Selective COX-II Inhibitor in the Human Liver Carcinoma Cell Line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30106414&form=6&db=m Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients. An experience from Western Saudi Arabia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30260024&form=6&db=m Associations between the cyclooxygenase-2 expression in circulating tumor cells and the clinicopathological features of patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30341914&form=6&db=m Cyclooxygenase-2 in cancer: A review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30668340&form=6&db=m Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683818&form=6&db=m The cyclooxygenase-2/prostaglandin E2 pathway and its role in the pathogenesis of human and dog hematological malignancies. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30726934&form=6&db=m MicroRNA-708 activation by glucocorticoid receptor agonists regulate breast cancer tumorigenesis and metastasis via downregulation of NF-?B signaling. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30761249&form=6&db=m Cyclooxygenase-2 expression correlates with development, progression, metastasis, and prognosis of osteosarcoma: a meta-analysis and trial sequential analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30784875&form=6&db=m New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30798928&form=6&db=m Possible role of PPAR-? and COX-2 receptor modulators in the treatment of Non-Small Cell lung carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30847405&form=6&db=m Studies of postpartum mammary gland involution reveal novel pro-metastatic mechanisms. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30907747&form=6&db=m Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30941969&form=6&db=m Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30987191&form=6&db=m Future Aspects for Cannabinoids in Breast Cancer Therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31052167&form=6&db=m Dihydropyrazole Derivatives Containing Benzo Oxygen Heterocycle and Sulfonamide Moieties Selectively and Potently Inhibit COX-2: Design, Synthesis, and Anti-Colon Cancer Activity Evaluation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31100474&form=6&db=m Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31114336&form=6&db=m Suppressing growth and invasion of human hepatocellular carcinoma cells by celecoxib through inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31179232&form=6&db=m Increased COX-2 Immunostaining in Urothelial Carcinoma of the Urinary Bladder Is Associated with Invasiveness and Poor Prognosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31492557&form=6&db=m Annexin10 promotes extrahepatic cholangiocarcinoma metastasis by facilitating EMT via PLA2G4A/PGE2/STAT3 pathway. ongoing research,unassigned 2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31494294&form=6&db=m A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31528165&form=6&db=m Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31655104&form=6&db=m Design and construction of COX-2 specific fluorescent probes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31675116&form=6&db=m Immunohistochemical detectability of cyclooxygenase-2 expression in cells of human melanocytic skin lesions: A methodological review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31685984&form=6&db=m Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. unassigned -
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31715374&form=6&db=m Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31739836&form=6&db=m Docosahexaenoic acid inhibits lipopolysaccharide-induced metastatic activities by decreasing inflammation on prostate cancer cell. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31759370&form=6&db=m An Investigation on the Therapeutic Potential of Butein, A Tretrahydroxychalcone Against Human Oral Squamous Cell Carcinoma. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31783895&form=6&db=m Cross-talk between SIM2s and NF?B regulates cyclooxygenase 2 expression in breast cancer. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31791289&form=6&db=m PPAR? ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31818070&form=6&db=m [Effect of GPX4 on proliferation and metastasis of renal clear cell carcinoma and its relationship with expression of IGF-1R and COX-2]. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31867776&form=6&db=m High COX-2 expression in cancer-associated fibiroblasts contributes to poor survival and promotes migration and invasiveness in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920649&form=6&db=m Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31935470&form=6&db=m In vivo preclinical evaluation of the new 68Ga-labeled beta-cyclodextrin in prostaglandin E2 (PGE2) positive tumor model using positron emission tomography. causal interaction,unassigned 2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32104177&form=6&db=m Antitumor Activity of Ficus deltoidea Extract on Oral Cancer: An In Vivo Study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32175764&form=6&db=m COX-2 promotes metastasis and predicts prognosis on gastric cancer via regulating mTOR. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32227417&form=6&db=m Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32264335&form=6&db=m pH-Responsive nanoparticles based on ibuprofen prodrug as drug carriers for inhibition of primary tumor growth and metastasis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269737&form=6&db=m Selective EP2 and Cox-2 inhibition suppresses cell migration by reversing epithelial-to-mesenchymal transition and Cox-2 overexpression and E-cadherin downregulation are implicated in neck metastasis of hypopharyngeal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32410997&form=6&db=m Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435431&form=6&db=m Evaluation of VEGF expression correlates with COX-2 expression in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32521872&form=6&db=m Effect of molecular targeted therapy combined with radiotherapy on the expression and prognostic value of COX-2 and VEGF in bone metastasis of lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32545325&form=6&db=m (-)-Oleocanthal as a Dual c-MET-COX2 Inhibitor for the Control of Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,3
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32554314&form=6&db=m Prognostic impact of immune-microenvironment in colorectal liver metastases resected after triplets plus a biologic agent: A pooled analysis of five prospective trials. unassigned -
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32565941&form=6&db=m Pathological roles of c-Met in bladder cancer: Association with cyclooxygenase-2, heme oxygenase-1, vascular endothelial growth factor-A and programmed death ligand 1. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32569637&form=6&db=m Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition. unassigned -
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32615181&form=6&db=m MicroRNAs in the anticancer effects of celecoxib: A systematic review. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903705&form=6&db=m Prognostic and Clinical Significance of Cyclooxygenase-2 Overexpression in Endometrial Cancer: A Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117682&form=6&db=m Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33119867&form=6&db=m COX-2 Signaling in the Tumor Microenvironment. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33327467&form=6&db=m Prognostic Significance of COX-2 Overexpression in BRAF-Mutated Middle Eastern Papillary Thyroid Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33364964&form=6&db=m Eicosanoids in Cancer: New Roles in Immunoregulation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33455946&form=6&db=m Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33545218&form=6&db=m A carrier-free anti-inflammatory platinum (II) self-delivered nanoprodrug for enhanced breast cancer therapy. causal interaction,unassigned 1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33578254&form=6&db=m A novel immunochemotherapy based on targeting of cyclooxygenase and induction of immunogenic cell death. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33588911&form=6&db=m Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33648517&form=6&db=m Correction to: Combination therapy of PKC? and COX-2 inhibitors synergistically suppress melanoma metastasis. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660801&form=6&db=m Curcumin-Celecoxib: a synergistic and rationale combination chemotherapy for breast cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33969138&form=6&db=m PTGS2 Over-Expression: A Colorectal Carcinoma Initiator not an Invasive Factor. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102280&form=6&db=m Iminodibenzyl redirected cyclooxygenase-2 catalyzed dihomo-?-linolenic acid peroxidation pattern in lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34103896&form=6&db=m Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34174268&form=6&db=m Concomitant use of analgesics and immune checkpoint inhibitors in non-small cell lung cancer: A pharmacodynamics perspective. causal interaction,unassigned 4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34189144&form=6&db=m Third-Generation Anti-CD47-Specific CAR-T Cells Effectively Kill Cancer Cells and Reduce the Genes Expression in Lung Cancer Cell Metastasis. ongoing research,unassigned 2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34216690&form=6&db=m Intracellular AGR2 transduces PGE2 stimuli to promote epithelial-mesenchymal transition and metastasis of colorectal cancer. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34257723&form=6&db=m Metformin suppresses breast cancer growth via inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34262017&form=6&db=m CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34335799&form=6&db=m Integrative Bioinformatics Study of Tangeretin Potential Targets for Preventing Metastatic Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34341904&form=6&db=m Preliminary evaluation of anticancer efficacy of pioglitazone combined with celecoxib for the treatment of non-small cell lung cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34389281&form=6&db=m MicroRNA and cyclooxygenase-2 in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34392440&form=6&db=m Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34398475&form=6&db=m Cyclooxygenase-2 protein expression modulates cell proliferation and apoptosis in solid ameloblastoma and odontogenic keratocyst. An immunohistochemical study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34436652&form=6&db=m Diclofenac down-regulates COX-2 induced expression of CD44 and ICAM-1 in human HT29 colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34466408&form=6&db=m High Immunoexpression of COX-2 as a Metastatic Risk Factor in ccRCC without PD-L1 Involvement. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasm Micrometastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15248379&form=6&db=m Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasm Micrometastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22025079&form=6&db=m The metastatic microenvironment: Brain-residing melanoma metastasis and dormant micrometastasis. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasm Micrometastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30819896&form=6&db=m COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasm, Residual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760075&form=6&db=m Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasm, Residual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16822500&form=6&db=m NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Neoplasm, Residual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20041097&form=6&db=m Correlation between tumor volume response to radiotherapy and expression of biological markers in patients with cervical squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasm, Residual http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33430037&form=6&db=m Concurrent Aspirin Use Is Associated with Improved Outcome in Rectal Cancer Patients Who Undergo Chemoradiation Therapy. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=55892&form=6&db=m Breast-cancer osteolysis, bone metastases, and anti-osteolytic effect of aspirin. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=109539&form=6&db=m Macrophage-mediated tumor cell killing: lack of dependence on the cyclooxygenase pathway of prostaglandin synthesis. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=121602&form=6&db=m Prostaglandin synthetase and prostaglandin E2 levels in human breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=476686&form=6&db=m Effects of phorbol ester tumor promoters in platelet aggregation and platelet production of cyclooxygenase products. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1305681&form=6&db=m Piroxicam and other cyclooxygenase inhibitors: potential for cancer chemoprevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1306527&form=6&db=m Effects of high and low dietary fat and indomethacin on tumour growth, hormone receptor status and growth factor expression in DMBA-induced rat breast cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1391532&form=6&db=m Cyclooxygenase inhibition with ibuprofen: effect on biodistribution of perflubron emulsions in mice with mammary tumor. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1415600&form=6&db=m Differential effects of WEB 2086 and SRI 63-441 on TNF-alpha-induced alterations in cardiopulmonary function. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1458478&form=6&db=m Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1475281&form=6&db=m Cytokine modulation of immune activation associated suppression of macrophage cyclooxygenase activity in vivo. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1546063&form=6&db=m Regulation of proliferation of rat mammary tumor cells by inhibitors of cyclooxygenase and lipoxygenase. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1546845&form=6&db=m The role of cyclooxygenase products in lung injury induced by tumor necrosis factor in sheep. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1550684&form=6&db=m Enhanced release of prostaglandin E2 from macrophages of rats with silicosis. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1587858&form=6&db=m Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1611619&form=6&db=m Studies of a tumor-associated antigen, COX-1, recognized by a monoclonal antibody. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1649146&form=6&db=m Lipid mediators of tumor necrosis factor-alpha-induced uveitis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1667043&form=6&db=m Eicosanoids and linoleate-enhanced growth of mouse mammary tumor cells. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1704236&form=6&db=m Polypeptide growth factors and angiogenesis. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1841624&form=6&db=m Participation of macrophages in the mechanism mediating the enhancement of metastasis formation after tumour resection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1847874&form=6&db=m Transcription, translation and secretion of interleukin 1 and tumor necrosis factor: effects of tebufelone, a dual cyclooxygenase/5-lipoxygenase inhibitor. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1899046&form=6&db=m Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1902078&form=6&db=m Cytokine release from mononuclear cells in patients irradiated for breast cancer. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1902395&form=6&db=m Effects of the prostaglandin synthetase inhibitor indomethacin on tumorigenesis, tumor proliferation, cell kinetics, and receptor contents of 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in Sprague-Dawley rats fed a high- or low-fat diet. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1908616&form=6&db=m Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1917383&form=6&db=m Thromboxane production by platelets during tumor cell-induced platelet activation. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2068050&form=6&db=m Effect of indomethacin on the kinetics of tumour necrosis factor alpha release and tumour necrosis factor alpha gene expression by human blood monocytes. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2074555&form=6&db=m Endotoxic shock. Part II: A review of treatment. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121380&form=6&db=m In vitro prostaglandin H synthase- and monooxygenase-mediated binding of aflatoxin B1 to DNA in guinea-pig tissue microsomes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2121637&form=6&db=m Impaired lipopolysaccharide-inducible tumor necrosis factor production in vitro by peripheral blood monocytes of patients with viral hepatitis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2126984&form=6&db=m The in vitro development of cytotoxicity in response to granulocyte/macrophage-colony-stimulating factor or interferon gamma in the peripheral blood monocytes of patients with solid tumors: modulation by arachidonic acid metabolic inhibitors. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2180648&form=6&db=m Cytokine networks involved in the regulation of haemopoietic stem cell proliferation and differentiation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2292356&form=6&db=m Protection by indomethacin against acute radiation esophagitis. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2338559&form=6&db=m Identification and characterization of cysteinyl-leukotriene formation in tissue slices from human intracranial tumors: evidence for their biosynthesis under in vivo conditions. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2420445&form=6&db=m Growth inhibition and eicosanoid metabolism in the R3230AC mammary adenocarcinoma by interferon. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2423014&form=6&db=m Tumor angiogenesis inhibition by prostaglandin synthetase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2439187&form=6&db=m Biologic response modifiers in genitourinary neoplasia. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492204&form=6&db=m Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494673&form=6&db=m Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2501827&form=6&db=m Influence of morphology and malignancy of three new human melanoma cell lines on the cyclooxygenase pathway. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2503244&form=6&db=m Linoleic acid metabolism in metastatic and nonmetastatic murine mammary tumor cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2508257&form=6&db=m Platelet and shear rate promote tumor cell adhesion to human endothelial extracellular matrix--absence of a role for platelet cyclooxygenase. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2513997&form=6&db=m Interleukin-1 and the effects of cyclooxygenase inhibitors on its biological activities. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2514267&form=6&db=m Inhibition of soybean lipoxygenase and mouse skin tumor promotion by onion and garlic components. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2518282&form=6&db=m Protection against pulmonary oxygen toxicity by interleukin-1 and tumor necrosis factor: role of antioxidant enzymes and effect of cyclooxygenase inhibitors. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2541705&form=6&db=m Eicosapentaenoic acid reduces the invasive and metastatic activities of malignant tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2550968&form=6&db=m Eicosanoid synthesis by alveolar macrophages in rats with malignant mammary tumors: differences in rats treated with and without carrageenan implants. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2591030&form=6&db=m Prevention of the toxic action of tumor necrosis factor by cyclooxygenase inhibitor and leukopenia. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2674360&form=6&db=m Prostaglandins in human brain tumors. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2770427&form=6&db=m Influence of omega-3 and omega-6 fatty acid sources on prostaglandin levels in mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2783725&form=6&db=m Comparative study of cytotoxicity, tumor necrosis factor, and prostaglandin release after stimulation of rat Kupffer cells, murine Kupffer cells, and murine inflammatory liver macrophages. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2785376&form=6&db=m Ibuprofen causes reduced toxic effects of interleukin 2 administration in patients with metastatic cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2835680&form=6&db=m Detection of circulating tumor necrosis factor after endotoxin administration. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988761&form=6&db=m Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3087430&form=6&db=m Characterization of prostaglandin endoperoxide synthase from a human cell line. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3089171&form=6&db=m [Anti-cancer treatment with prostaglandin synthetase inhibitor in animal models] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3100032&form=6&db=m Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108890&form=6&db=m The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3109414&form=6&db=m The role of platelet cyclooxygenase and lipoxygenase pathways in tumor cell induced platelet aggregation. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3111384&form=6&db=m [Inhibition of the growth of a murine transplantable tumor, colon 26, by the prostaglandin synthetase inhibitor, indomethacin] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115109&form=6&db=m Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3125055&form=6&db=m The induction of ornithine decarboxylase caused by 12-O-tetradecanoylphorbol-13-acetate in isolated epidermal cells is inhibited by lipoxygenase inhibitors but not by cyclooxygenase inhibitors. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3126274&form=6&db=m Arachidonic acid metabolic profiles in human meningiomas and gliomas. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3129228&form=6&db=m Synthesis of eicosanoids by gamma-interferon-differentiated U937 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3257168&form=6&db=m Augmented antitumor effect of recombinant human interleukin-1 alpha by indomethacin. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3258319&form=6&db=m Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3462058&form=6&db=m Modulation of tumor cell motility by prostaglandins and inhibitors of prostaglandin synthesis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3486658&form=6&db=m Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3802391&form=6&db=m Inhibition by indomethacin and 5,8,11,14-eicosatetraynoic acid of the induction of rat hepatic ornithine decarboxylase by the tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in vivo. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3803107&form=6&db=m Antitumor effects of inhibitors of arachidonic acid cascade on experimentally induced intestinal tumors. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3900514&form=6&db=m Failure of indomethacin to inhibit growth of the R3230AC mammary tumor in rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3917850&form=6&db=m Inhibition of human malignant neuroblastoma cell DNA synthesis by lipoxygenase metabolites of arachidonic acid. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3918211&form=6&db=m Response of Walker 256 carcinosarcoma cells to 12-O-tetradecanoylphorbol 13-acetate: possible regulation by endogenous cyclooxygenase metabolites. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3926304&form=6&db=m Prostaglandin and thromboxane synthesis by Lewis lung carcinoma during growth. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6202890&form=6&db=m Indomethacin and poly I:C in the inhibition of carcinogen-induced bladder cancer in an experimental animal model. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6232242&form=6&db=m Suppression of polyclonal, tumor cell and alloantigen-induced proliferation: identification of cyclooxygenase pathway dependent and independent mechanisms. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6409616&form=6&db=m Prostaglandin concentrations and prostaglandin synthetase activity in N-nitrosomethylurea-induced rat mammary adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6432306&form=6&db=m Growth inhibition and prostaglandin metabolism in the R3230AC mammary adenocarcinoma by reduced glutathione. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6436837&form=6&db=m The influence of arachidonic acid metabolites on cell division in the intestinal epithelium and in colonic tumors. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6585268&form=6&db=m Prostaglandins in carcinomas of the head and neck. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6768115&form=6&db=m The direct inhibition of prostaglandin synthetase of human breast cancer tumor tissue by tamoxifen. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6782166&form=6&db=m Prostaglandin synthetase inhibitors as immunoadjuvants in the treatment of cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7129717&form=6&db=m Relationship of the suppression of macrophage mediated tumor cytotoxicity in conjunction with secretion of prostaglandin from the macrophages of breast cancer patients. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7530235&form=6&db=m Inhibition of TPA and 12(S)-HETE-stimulated tumor cell adhesion by prostacyclin and its stable analogs: rationale for their antimetastatic effects. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7538729&form=6&db=m A model of intrauterine infection and preterm delivery in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7562546&form=6&db=m New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575573&form=6&db=m Essential role of NF-kappa B activation in silica-induced inflammatory mediator production in macrophages. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575612&form=6&db=m Activation of 2-aminofluorene by prostaglandin endoperoxide H synthase-2. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7575673&form=6&db=m Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial. Novel effects independent of inhibition of lipid mediator production. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7583965&form=6&db=m Surgical infections: blocking the mediator cascade responsible for sepsis and septic shock. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7585482&form=6&db=m The mRNA overexpression of inflammatory enzymes, phospholipase A2 and cyclooxygenase, in the large bowel mucosa and neoplasms of F344 rats treated with naturally occurring carcinogen, 1-hydroxyanthraquinone. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7589737&form=6&db=m Clinical evaluations of a new ovarian cancer marker, COX-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7606198&form=6&db=m Measurement of prostaglandin E2 in rectal mucosa in human subjects: a method study. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7624508&form=6&db=m Induction of cyclooxygenase and prostaglandin E2 production by the bovine pre-embryo. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7641194&form=6&db=m Expression of cyclooxygenase-1 and -2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7671241&form=6&db=m Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706475&form=6&db=m Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7757981&form=6&db=m Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7777237&form=6&db=m The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7780341&form=6&db=m [Synthesis of arachidonic acid cascade eicosanoids in tumors of various histogenesis in mice] causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7780968&form=6&db=m Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7812955&form=6&db=m Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7818763&form=6&db=m Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7827287&form=6&db=m Cyclooxygenase inhibitors enhance tumour necrosis factor production and mortality in murine endotoxic shock. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7882354&form=6&db=m Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7897158&form=6&db=m Products of arachidonic acid metabolism and the effects of cyclooxygenase inhibition on ongoing cutaneous allergic reactions in human beings. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7926468&form=6&db=m Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7943398&form=6&db=m Effects of TNF-alpha on hemodynamic changes and circulating endothelium-derived vasoactive factors in dogs. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8002047&form=6&db=m Interactions between cytokines and eicosanoids: a study using human peritoneal macrophages. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8040024&form=6&db=m Ketoconazole attenuates radiation-induction of tumor necrosis factor. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8065730&form=6&db=m Arachidonic acid metabolites in saliva of patients with squamous cell carcinoma of the head and neck. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137463&form=6&db=m Cyclooxygenase and lipoxygenase inhibitors as modulators of cancer therapies. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8228569&form=6&db=m Altered eicosanoid levels in human colon cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8245715&form=6&db=m Involvement of inflammatory mediators in macrophage antitumor activity. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8269984&form=6&db=m Enhanced endothelial cell retraction mediated by 12(S)-HETE: a proposed mechanism for the role of platelets in tumor cell metastasis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8295980&form=6&db=m Tumor necrosis factor alpha stimulates amnion prostaglandin biosynthesis primarily via an action on fatty acid cyclooxygenase. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8325608&form=6&db=m Gram-negative bacterial lipopolysaccharide impairs hyaluronan clearance in vivo and its uptake by the isolated, perfused rat liver. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8361173&form=6&db=m Blockade of prostaglandin products augments macrophage and neutrophil tumor necrosis factor synthesis in burn injury. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8380961&form=6&db=m ESR studies on reactivity of protein-derived tyrosyl radicals formed by prostaglandin H synthase and ribonucleotide reductase. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391924&form=6&db=m Sensitivity of tumoricidal function in macrophages from different anatomical sites of cancer patients to modulation of arachidonic acid metabolism. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8399066&form=6&db=m Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8478151&form=6&db=m Studies on the role of platelet eicosanoid metabolism and integrin alpha IIb beta 3 in tumor-cell-induced platelet aggregation. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8502590&form=6&db=m Increased levels of luminol-enhanced chemiluminescence by rectal mucosa of patients with colonic neoplasia: a possible marker for colonic neoplasia. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8507112&form=6&db=m Tumor necrosis factor-induced mortality is reversed with cyclooxygenase inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8537402&form=6&db=m Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8545605&form=6&db=m Cytosolic phospholipase A2 and cyclooxygenase-2 mediate release and metabolism of arachidonic acid in tumor necrosis factor-alpha-primed cultured intestinal epithelial cells (INT 407). causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8564967&form=6&db=m Modulating effect of amount and types of dietary fat on colonic mucosal phospholipase A2, phosphatidylinositol-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8566864&form=6&db=m Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8613017&form=6&db=m Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8632179&form=6&db=m Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8640756&form=6&db=m Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8643486&form=6&db=m Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8653697&form=6&db=m Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8660662&form=6&db=m Regulation of prostaglandin endoperoxide H synthase-2 expression by 2,3,7,8,-tetrachlorodibenzo-p-dioxin. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8737749&form=6&db=m Nitric oxide enhances cyclooxygenase activity in articular cartilage. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8769813&form=6&db=m Bidirectional effects of hepatic ischemia/reperfusion on E. coli-induced TNF-alpha gene expression. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8771566&form=6&db=m Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8831610&form=6&db=m Elevated cyclooxygenase-2 levels in Min mouse adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8832221&form=6&db=m Evidence for tumor necrosis factor alpha as a mediator of the toxicity of a cyclooxygenase inhibitor in Gram-negative sepsis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8835089&form=6&db=m Cardiopulmonary effects of tumor necrosis factor-alpha in the piglet: influence of cyclooxygenase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8840426&form=6&db=m Are cytokines possible mediators of cancer cachexia? causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8840961&form=6&db=m Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8852946&form=6&db=m Interleukin-4 inhibits prostaglandin G/H synthase-2 and cytosolic phospholipase A2 induction in neonatal mouse parietal bone cultures. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8909974&form=6&db=m Effects of tenidap on intracellular signal transduction and the induction of proinflammatory cytokines: a review. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8917629&form=6&db=m The role of cyclic AMP and oxygen intermediates in the inhibition of cellular immunity in cancer. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8931116&form=6&db=m Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8939949&form=6&db=m Regulation of cyclooxygenases by protein kinase C. Evidence against the importance of direct enzyme phosphorylation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8945508&form=6&db=m Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8960892&form=6&db=m Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8979307&form=6&db=m Regulation of COX-2 gene expression in rat uterus in vivo and in vitro. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8992490&form=6&db=m Cyclooxygenase and lipoxygenase inhibitors in cancer therapy. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9006670&form=6&db=m Role of arachidonic acid metabolites in tumor growth inhibition by nonsteroidal antiinflammatory drugs. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9013627&form=6&db=m Induction of cyclooxygenase-2 expression by peroxisome proliferators and non-tetradecanoylphorbol 12,13-myristate-type tumor promoters in immortalized mouse liver cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9023325&form=6&db=m Induction of prostaglandin H synthase-2 and tumor necrosis factor-alpha in human amnionic WISH cells by various stimuli occurs through distinct intracellular mechanisms. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9041257&form=6&db=m Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9057838&form=6&db=m Expression and regulation of cyclooxygenase-2 in rat microglia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9067275&form=6&db=m Retinoids suppress phorbol ester-mediated induction of cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9096394&form=6&db=m Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9099957&form=6&db=m Induction of cyclo-oxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9099989&form=6&db=m The inhibitory effect of vitamin E on pulmonary polyamine biosynthesis, cell proliferation and carcinogenesis in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9102213&form=6&db=m Expression of cyclooxygenase-2 in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9106644&form=6&db=m Protective effects of silymarin against photocarcinogenesis in a mouse skin model. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9111217&form=6&db=m Benzo[a]pyrene up-regulates cyclooxygenase-2 gene expression in oral epithelial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9119467&form=6&db=m Bacterial porins stimulate bone resorption. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9138698&form=6&db=m Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9151799&form=6&db=m Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9212803&form=6&db=m [Chemoprevention of familial cancer] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9214456&form=6&db=m Cholesterol supplementation prevents necrosis and inflammation but enhances fibrosis in alcoholic liver disease in the rat. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9216939&form=6&db=m Endotoxin priming of thromboxane-related vasoconstrictor responses in perfused rabbit lungs. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9229572&form=6&db=m Introduction to eicosanoids and the gastroenteric tract. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9230197&form=6&db=m Retinoids suppress epidermal growth factor-induced transcription of cyclooxygenase-2 in human oral squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9230200&form=6&db=m Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9242654&form=6&db=m Prostaglandin E2 amplifies cytosolic phospholipase A2- and cyclooxygenase-2-dependent delayed prostaglandin E2 generation in mouse osteoblastic cells. Enhancement by secretory phospholipase A2. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249646&form=6&db=m COX-1 and COX-2 tissue expression: implications and predictions. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9261162&form=6&db=m Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 overexpression. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9270014&form=6&db=m Dietary fat and colon cancer: modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9288778&form=6&db=m Enhancement of experimental colon cancer by genistein. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9303324&form=6&db=m New aspects of mast cell biology. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9337697&form=6&db=m Cytosolic phospholipase A2, cyclo-oxygenases and arachidonate in human stomach tumours. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9349689&form=6&db=m Inhibition of cyclooxygenase: a novel approach to cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9353183&form=6&db=m Recent advances in chemoprevention of cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9359485&form=6&db=m Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HEJ mice. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9383784&form=6&db=m Effects of dietary menhaden oil, soy, and a cyclooxygenase inhibitor on human breast cancer cell growth and metastasis in nude mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9388257&form=6&db=m Tumor necrosis factor-alpha inversely regulates prostaglandin D2 and prostaglandin E2 production in murine macrophages. Synergistic action of cyclic AMP on cyclooxygenase-2 expression and prostaglandin E2 synthesis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9397995&form=6&db=m Dietary saturated fatty acids down-regulate cyclooxygenase-2 and tumor necrosis factor alfa and reverse fibrosis in alcohol-induced liver disease in the rat. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9405496&form=6&db=m Expression of prostaglandin G/H synthase type 1, but not type 2, in human ovarian adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9426072&form=6&db=m Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9430720&form=6&db=m Cytosolic phospholipase A2 is required for cytokine-induced expression of type IIA secretory phospholipase A2 that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E2 generation in rat 3Y1 fibroblasts. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9435204&form=6&db=m The 21-aminosteroid 16-desmethyl tirilazad mesylate prevents necroinflammatory changes in experimental alcoholic liver disease. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9437637&form=6&db=m Rheumatoid arthritis: current clinical and research directions. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9440135&form=6&db=m Tumor necrosis factor-alpha promotes sustained cyclooxygenase-2 expression: attenuation by dexamethasone and NSAIDs. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9443418&form=6&db=m Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9443907&form=6&db=m Prostaglandins: critical roles in pregnancy and colon cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9444604&form=6&db=m The renal medullary thick ascending limb as a model for understanding lipid mediators in sepsis. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9445308&form=6&db=m Hyperventilation induces release of cytokines from perfused mouse lung. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9453538&form=6&db=m Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458081&form=6&db=m Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9458096&form=6&db=m Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9463402&form=6&db=m Compensatory prostaglandin E2 biosynthesis in cyclooxygenase 1 or 2 null cells. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9464506&form=6&db=m Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9466472&form=6&db=m Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9488252&form=6&db=m Histamine receptor antagonists, cyclooxygenase blockade, and tumor necrosis factor during acute septic insult. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9515807&form=6&db=m Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9520464&form=6&db=m Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9521170&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9547657&form=6&db=m Tumor infiltrating lymphocytes in squamous cell carcinoma of the head and neck: mechanisms of enhancement using prostaglandin synthetase inhibitors. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9561165&form=6&db=m Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9561441&form=6&db=m Mechanism of action of antiinflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9561442&form=6&db=m Transcriptional regulation of fatty acid cyclooxygenases-1 and -2. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9576062&form=6&db=m Tumour necrosis factor-alpha-dependent regulation of prostaglandin endoperoxide synthase-2. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9579511&form=6&db=m Induction of cyclooxygenase-2 in alveolar macrophages after acid aspiration: selective cyclooxygenase-2 blockade reduces interleukin-6 production. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9580637&form=6&db=m Tyrosine phosphatase-dependent/tyrosine kinase-independent induction of nuclear factor-kappa B by tumor necrosis factor-alpha: effects on prostaglandin endoperoxide synthase-2 mRNA accumulation. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9584837&form=6&db=m Tumour necrosis factor-alpha stimulates increased expression of prostaglandin endoperoxide H synthase Type 2 mRNA in amnion-derived WISH cells. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9602052&form=6&db=m Cyclooxygenase-2 is induced in brain blood vessels during fever evoked by peripheral or central administration of tumor necrosis factor. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9615719&form=6&db=m Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinflammatory drugs. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9622066&form=6&db=m Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9632078&form=6&db=m Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by interleukin 1alpha, tumor necrosis factor-alpha, glucocorticoids, and 17beta-estradiol. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635856&form=6&db=m COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679948&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696706&form=6&db=m Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9703885&form=6&db=m Cyclooxygenase-2 expression in human adenocarcinoma cell line HT29 cl.19A. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9713099&form=6&db=m [Effect of lysine clonixinate and indomethacin on lipoxygenase and cyclooxygenase activity in colon isolated from cancer patients] ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9722548&form=6&db=m Role of NF-kappaB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-alpha in human hepatic stellate cells. Involvement of cyclooxygenase-2. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726636&form=6&db=m Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9731479&form=6&db=m Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9736921&form=6&db=m Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9737710&form=6&db=m Cyclooxygenase in biology and disease. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9739782&form=6&db=m Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9744535&form=6&db=m Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9758210&form=6&db=m Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9763540&form=6&db=m Differential induction of cyclooxygenase-2 in human arterial and venous smooth muscle: role of endogenous prostanoids. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765305&form=6&db=m Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766436&form=6&db=m Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9809985&form=6&db=m Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9809998&form=6&db=m The inducible prostaglandin biosynthetic enzyme, cyclooxygenase 2, is not mutated in patients with attenuated adenomatous polyposis coli. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9811310&form=6&db=m Cyclooxygenase-2 inhibitors in tumorigenesis (Part II). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823297&form=6&db=m Expression of cyclooxygenase-2 in human lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9824628&form=6&db=m Influence of dietary linoleic acid on experimental human breast cancer cell metastasis in athymic nude mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831333&form=6&db=m COX-2 and colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9841832&form=6&db=m Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9846504&form=6&db=m Expression of cyclooxygenase-2 protein in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9850081&form=6&db=m Reduced COX-2 protein in colorectal cancer with defective mismatch repair. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9850741&form=6&db=m Cox-2, iNOS and p53 as play-makers of tumor angiogenesis (review). causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9858896&form=6&db=m Gene expression of cyclooxygenase-2, group II and cytosolic phospholipase A2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9863662&form=6&db=m Expression of cyclooxygenase-2 in foetal rat hepatocytes stimulated with lipopolysaccharide and pro-inflammatory cytokines. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9867839&form=6&db=m p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9868534&form=6&db=m Intracellular Ca2+ mediates lipoxygenase-induced proliferation of U-373 MG human astrocytoma cells. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872498&form=6&db=m Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9875706&form=6&db=m Enhancement of slow-wave sleep by tumor necrosis factor-alpha is mediated by cyclooxygenase-2 in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9877447&form=6&db=m Tumor necrosis factor-alpha upregulates the prostaglandin E2 EP1 receptor subtype and the cyclooxygenase-2 isoform in cultured amnion WISH cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886578&form=6&db=m Meloxicam inhibits the growth of colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9888205&form=6&db=m Helicobacter pylori infection induces cyclooxygenase-2 expression in human gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9892207&form=6&db=m Cyclooxygenase-2 expression in human esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9893042&form=6&db=m Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9917869&form=6&db=m Neurobiological basis of fever. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927043&form=6&db=m A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9927047&form=6&db=m Expression of 15-lipoxygenase-1 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9987964&form=6&db=m [Hormones and auto-paracrine tumor growth regulators in osteogenic sarcoma] causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9990216&form=6&db=m [Current topics in the regulation of prostanoids--2. The interaction with cytokines and nitric oxide] unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022281&form=6&db=m Mechanisms of quinolone phototoxicity. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10022645&form=6&db=m Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10023661&form=6&db=m Transformation of intestinal epithelial cells by chronic TGF-beta1 treatment results in downregulation of the type II TGF-beta receptor and induction of cyclooxygenase-2. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10024686&form=6&db=m Inhibition by dietary menhaden oil of cyclooxygenase-1 and -2 in N-nitrosomethylurea-induced rat mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10027203&form=6&db=m Chemoprevention of colorectal cancer: dietary and pharmacologic approaches. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10051469&form=6&db=m Expression of cyclooxygenase-2 in human hepatocellular carcinoma: relevance to tumor dedifferentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10069452&form=6&db=m Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10075740&form=6&db=m Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10188882&form=6&db=m Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10196169&form=6&db=m Inhibition of cyclooxygenase-2 gene expression by p53. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10197601&form=6&db=m Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10200295&form=6&db=m Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10204802&form=6&db=m Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10208989&form=6&db=m Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1beta. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10213117&form=6&db=m Cyclooxygenase (COX)-2 immunoreactivity and relationship to p53 and Ki-67 expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10223192&form=6&db=m Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10223193&form=6&db=m Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10226539&form=6&db=m Expression of cyclooxygenase-2 in human squamous cell carcinoma of the esophagus; an immunohistochemical survey. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10228831&form=6&db=m Cyclooxygenase-2 expression in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10229132&form=6&db=m Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10232612&form=6&db=m Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10328326&form=6&db=m Synthetic pathways of gallbladder mucosal prostanoids: the role of cyclooxygenase-1 and 2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10337718&form=6&db=m Metabolic targets of cancer chemoprevention: interruption of tumor development by inhibitors of arachidonic acid metabolism. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10353732&form=6&db=m Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10370867&form=6&db=m Cancer chemopreventive activity of resveratrol. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10381133&form=6&db=m Effects of resveratrol on 12-O-tetradecanoylphorbol-13-acetate-induced oxidative events and gene expression in mouse skin. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390128&form=6&db=m The clinical potential of cyclooxygenase-2-specific inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10398082&form=6&db=m Early expression of cyclo-oxygenase-2 during sporadic colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10399316&form=6&db=m Cyclooxygenase-1 and -2 isoenzymes. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402236&form=6&db=m The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10404093&form=6&db=m Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10405195&form=6&db=m Deregulation of cyclooxygenase and nitric oxide synthase gene expression in the inflammatory cascade triggered by experimental group B streptococcal meningitis in the newborn brain and cerebral microvessels. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411006&form=6&db=m Regulation of the plasminogen activator inhibitor-2 (PAI-2) gene in murine macrophages. Demonstration of a novel pattern of responsiveness to bacterial endotoxin. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10414396&form=6&db=m Expression and localization of COX-2 in human airways and cultured airway epithelial cells. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417761&form=6&db=m Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10418820&form=6&db=m Acetaldehyde prevents nuclear factor-kappa B activation and hepatic inflammation in ethanol-fed rats. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419916&form=6&db=m Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10422778&form=6&db=m Possible participation of intracellular platelet-activating factor in tumor necrosis factor-alpha production by rat peritoneal macrophages. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10425287&form=6&db=m Expression of cyclooxygenase-2 in human adenocarcinomas of the gastric cardia and corpus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10426785&form=6&db=m Effect of lindane and phenobarbital on cyclooxygenase-2 expression and prostanoid synthesis by Kupffer cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10433483&form=6&db=m Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10444394&form=6&db=m Myofibroblasts. II. Intestinal subepithelial myofibroblasts. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449029&form=6&db=m Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10451445&form=6&db=m Induction of prostaglandin G/H synthase-2 in a canine model of spontaneous prostatic adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10452868&form=6&db=m Products of cyclooxygenase-2 catalysis regulate postoperative bowel motility. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10455907&form=6&db=m Cyclooxygenase-2 alters transforming growth factor-beta 1 response during intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10463387&form=6&db=m Cadmium-induced calcium release and prostaglandin E2 production in neonatal mouse calvaria are dependent on cox-2 induction and protein kinase C activation. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10469752&form=6&db=m Enhancement of tumor response to gamma-radiation by an inhibitor of cyclooxygenase-2 enzyme. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10471521&form=6&db=m Coordinate up-regulation of low-density lipoprotein receptor and cyclo-oxygenase-2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10473081&form=6&db=m Overexpression of cyclooxygenase-2 in carcinoma of the pancreas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10480347&form=6&db=m Hypoxia induces pivotal tumor angiogenesis control factors including p53, vascular endothelial growth factor and the NFkappaB-dependent inducible nitric oxide synthase and cyclooxygenase-2. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10483780&form=6&db=m Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485483&form=6&db=m Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10487525&form=6&db=m Cyclooxygenase knockout mice: models for elucidating isoform-specific functions. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10488092&form=6&db=m Galpha(13) stimulates Rho-dependent activation of the cyclooxygenase-2 promoter. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10491379&form=6&db=m Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10501211&form=6&db=m Signaling mechanisms involved in the activation of arachidonic acid metabolism in human astrocytoma cells by tumor necrosis factor-alpha: phosphorylation of cytosolic phospholipase A2 and transactivation of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10504298&form=6&db=m Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotion. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10506108&form=6&db=m Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10508481&form=6&db=m High expression of cyclooxygenase-2 in macrophages of human colonic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10515422&form=6&db=m Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517428&form=6&db=m The relationship between cyclooxygenase-2 expression and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517891&form=6&db=m COX-2 in large bowel cancer: a one-sided story. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517910&form=6&db=m Differential expression of cyclooxygenase 2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10526229&form=6&db=m Induction of prostaglandin I(2) receptor by tumor necrosis factor alpha in osteoblastic MC3T3-E1 cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10557090&form=6&db=m Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10560661&form=6&db=m In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10569809&form=6&db=m Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10574921&form=6&db=m Gangliosides activate cultured rat brain microglia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10579801&form=6&db=m Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10588517&form=6&db=m The effects of two new antagonists of secretory PLA2 on TNF, iNOS, and COX-2 expression in activated macrophages. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10595745&form=6&db=m A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597402&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10599732&form=6&db=m Interleukin-10 modifies the effects of interleukin-1beta and tumor necrosis factor-alpha on the activity and expression of prostaglandin H synthase-2 and the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase in cultured term human villous trophoblast and chorion trophoblast cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10605031&form=6&db=m Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10607728&form=6&db=m Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10616198&form=6&db=m Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10617597&form=6&db=m Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10625599&form=6&db=m n-3 fatty acids specifically modulate catabolic factors involved in articular cartilage degradation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630181&form=6&db=m Chemoprevention in hereditary colorectal cancer syndromes. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10630643&form=6&db=m The role of cyclooxygenases in inflammation, cancer, and development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10631313&form=6&db=m Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10632332&form=6&db=m Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10640421&form=6&db=m Lack of cyclooxygenase-2 inhibits growth of teratocarcinomas in mice. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10647629&form=6&db=m Cellular localization of cyclo-oxygenase isozymes in Crohn's disease and colorectal cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10648462&form=6&db=m Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10656441&form=6&db=m Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657949&form=6&db=m Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10665651&form=6&db=m Cyclooxygenase-2 (COX-2) mRNA expression levels in normal lung tissues and non-small cell lung cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10666384&form=6&db=m Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10667579&form=6&db=m Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668483&form=6&db=m Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668484&form=6&db=m The role of COX-2 in intestinal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668485&form=6&db=m COX-2 inhibitors. A new class of antiangiogenic agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668496&form=6&db=m Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10671533&form=6&db=m Benzo[a]pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. Evidence for the involvement of extracellular signal-regulated kinase and NF-kappaB. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10675387&form=6&db=m Re: Enhancement of tumor response to gamma-radiation by an inhibitor of cyclooxygenase-2 enzyme. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10675388&form=6&db=m RESPONSE: re: enhancement of tumor response to gamma-radiation by an inhibitor of cyclooxygenase-2 enzyme causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10676778&form=6&db=m Advances in the medical treatment of juvenile rheumatoid arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678579&form=6&db=m Molecular pathology of cyclooxygenase-2 in neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10679902&form=6&db=m Effects of arachidonic acid metabolites in a murine model of squamous cell carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10683418&form=6&db=m Traumatic injury induces differential expression of cell death genes in organotypic brain slice cultures determined by complementary DNA array hybridization. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10684704&form=6&db=m High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10690533&form=6&db=m Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10695990&form=6&db=m Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10697514&form=6&db=m Comparative ability of ibuprofen and N-(4-hydroxyphenyl)retinamide to inhibit development of rat mammary adenocarcinomas associated with differential inhibition of gene expression of cyclooxygenase isoforms. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10706128&form=6&db=m Transcriptional regulation of cyclooxygenase-2 gene expression: novel effects of nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10708932&form=6&db=m Cancer chemoprevention through interruption of multistage carcinogenesis. The lessons learnt by comparing mouse skin carcinogenesis and human large bowel cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710473&form=6&db=m Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710483&form=6&db=m COX-2 and colon cancer: Potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10722929&form=6&db=m Cyclooxygenase-2 and carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728691&form=6&db=m Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728694&form=6&db=m Preferential enhancement of tumor radioresponse by a cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10736244&form=6&db=m Differential regulation in human amnion epithelial and fibroblast cells of prostaglandin E(2) production and prostaglandin H synthase-2 mRNA expression by dexamethasone but not tumour necrosis factor-alpha. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10744623&form=6&db=m Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10749148&form=6&db=m Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10753183&form=6&db=m High cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) contents in mouse lung tumors. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762011&form=6&db=m Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762021&form=6&db=m COX-2 and colon cancer: potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766802&form=6&db=m Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10772414&form=6&db=m Nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10772828&form=6&db=m Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10778945&form=6&db=m Up-regulation of cyclooxygenase-2 in squamous carcinogenesis of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10783318&form=6&db=m Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10785514&form=6&db=m Cyclooxygenase-2 is required for tumor necrosis factor-alpha- and angiotensin II-mediated proliferation of vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10797271&form=6&db=m Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10797288&form=6&db=m Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: evidence for growth suppression by inhibiting COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10803639&form=6&db=m Expression of cyclooxygenase-2 in transitional cell carcinoma of the urinary bladder in dogs. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10810453&form=6&db=m Differential regulation of cyclooxygenase-2 (COX-2) mRNA stability by interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in human in vitro differentiated macrophages. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10814787&form=6&db=m Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10828079&form=6&db=m Prostaglandin E(2) regulation of cyclooxygenase expression in keratinocytes is mediated via cyclic nucleotide-linked prostaglandin receptors. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10832673&form=6&db=m Details of hyperplastic polyps of the stomach shrinking after anti-Helicobacter pylori therapy. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10837804&form=6&db=m Cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-prostaglandin J(2) acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10841517&form=6&db=m Host cyclooxygenase-2 modulates carcinoma growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10861458&form=6&db=m Effect of the specific cyclooxygenase-2 inhibitor meloxicam on tumour growth and cachexia in a murine model. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10866999&form=6&db=m Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10869354&form=6&db=m Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10871323&form=6&db=m Effect of lipoteichoic acid on dermal vascular permeability in mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873095&form=6&db=m Cyclooxygenase-2 expression is up-regulated in transitional cell carcinoma and its preneoplastic lesions in the human urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10873107&form=6&db=m Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874016&form=6&db=m Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10889181&form=6&db=m Prevention of colorectal cancer: tumor progression, chemoprevention, and COX-2 inhibition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10898763&form=6&db=m Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10910034&form=6&db=m Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10911017&form=6&db=m Recent advances in inducible cyclooxygenase (COX-2) inhibition. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10911914&form=6&db=m Translational studies on Cox-2 inhibitors in the prevention and treatment of colon cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10917546&form=6&db=m Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10919635&form=6&db=m Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10919714&form=6&db=m Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10931458&form=6&db=m Expression of cyclooxygenase-2 in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10935498&form=6&db=m Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10948706&form=6&db=m [Cyclooxygenase-2 inhibitors and cancer prevention] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953162&form=6&db=m Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth of prostate cancer in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953335&form=6&db=m Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10960277&form=6&db=m COX-2 in murine intestinal tumors. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10969813&form=6&db=m Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980113&form=6&db=m The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987288&form=6&db=m Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10987308&form=6&db=m Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10993880&form=6&db=m Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10999385&form=6&db=m Effect of cyclooxygenase inhibitors in the adhesion of tumor cells to endothelial cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005841&form=6&db=m gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005842&form=6&db=m Intracellular unesterified arachidonic acid signals apoptosis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11011115&form=6&db=m Chemoprevention by nimesulide, a selective cyclooxygenase-2 inhibitor, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary gland carcinogenesis in rats. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11016626&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11023542&form=6&db=m Suppression by citrus auraptene of phorbol ester-and endotoxin-induced inflammatory responses: role of attenuation of leukocyte activation. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11027488&form=6&db=m Differential regulation of COX-2 transcription by Ras- and Rho-family of GTPases. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029518&form=6&db=m Cyclooxygenase expression in the gallbladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032917&form=6&db=m Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032948&form=6&db=m Chemotherapeutic evaluation of Celecoxib, a cyclooxygenase-2 inhibitor, in a rat mammary tumor model. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032965&form=6&db=m Role of cyclooxygenases in angiogenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11033048&form=6&db=m Helicobacter pylori infection and gastrin and cyclooxygenase expression in gastric and colorectal malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11048802&form=6&db=m Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11050051&form=6&db=m Exacerbation of alcoholic liver injury by enteral endotoxin in rats. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11051257&form=6&db=m Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11053908&form=6&db=m Indomethacin inhibits the accumulation of tumor cells in mouse lungs and subsequent growth of lung metastases. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059772&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11069387&form=6&db=m Cytoplasmic induction and over-expression of cyclooxygenase-2 in human prostate cancer: implications for prevention and treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078056&form=6&db=m Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11085996&form=6&db=m The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11087869&form=6&db=m Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090944&form=6&db=m A causal relationship between unscheduled eicosanoid signaling and tumor development: cancer chemoprevention by inhibitors of arachidonic acid metabolism. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090967&form=6&db=m Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11091570&form=6&db=m Dietary Fat, Fatty Acids and Breast Cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093779&form=6&db=m Induction of p27(KIP1) as a mechanism underlying NS398-induced growth inhibition in human lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095928&form=6&db=m Tumour necrosis factor-alpha regulation of prostaglandin H synthase-2 transcription is not through nuclear factor-kappaB in amnion-derived AV-3 cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11108134&form=6&db=m Attenuation of macrophage apoptosis by the cAMP-signaling system. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11109595&form=6&db=m [Non-steroidal anti-inflammatory agents with selective inhibitory activity on cyclooxygenase-2. Interest and future prospects] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115617&form=6&db=m Zaltoprofen prevents carbon tetrachloride-induced reduction of body weight in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115827&form=6&db=m Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121536&form=6&db=m Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11122864&form=6&db=m Advances in cancer pain management. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133175&form=6&db=m COX and LOX eicosanoids modulate platelet activation and procoagulation induced by two murine cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133817&form=6&db=m Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: possible c-Src-mediated pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135226&form=6&db=m COX-2 is expressed in human pulmonary, colonic, and mammary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11139815&form=6&db=m Potential utility of COX-2 inhibitors in chemoprevention and chemotherapy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11140899&form=6&db=m Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11149225&form=6&db=m [Cyclooxygenase-2 (COX-2) in digestive cancer. Therapeutic implications] unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11150521&form=6&db=m Potential role of group X secretory phospholipase A(2) in cyclooxygenase-2-dependent PGE(2) formation during colon tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156258&form=6&db=m Correspondence re: M. Kondo et al., Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin. Cancer Res., 5: 4005-4012, 1999. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156377&form=6&db=m 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158257&form=6&db=m Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159047&form=6&db=m Cytokine-induced bronchoconstriction in precision-cut lung slices is dependent upon cyclooxygenase-2 and thromboxane receptor activation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159736&form=6&db=m Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11159881&form=6&db=m Colonic luminal contents induce cyclooxygenase 2 transcription in human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11161397&form=6&db=m Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162356&form=6&db=m Blockade NF-kappaB activation prohibits TNF-alpha-induced cyclooxygenase-2 gene expression in ED27 trophoblast-like cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162632&form=6&db=m Ultraviolet B(UVB)-induced cox-2 expression in murine skin: an immunohistochemical study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11170304&form=6&db=m TGF-beta and colorectal carcinogenesis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11170729&form=6&db=m Effects of interleukin-10 (IL-10) on pain behavior and gene expression following excitotoxic spinal cord injury in the rat. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11176123&form=6&db=m Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179120&form=6&db=m Granulocyte-macrophage colony-stimulating factor amplifies lipopolysaccharide-induced bronchoconstriction by a neutrophil- and cyclooxygenase 2-dependent mechanism. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179444&form=6&db=m Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11180079&form=6&db=m Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11191059&form=6&db=m The contributions of cyclooxygenase-2 to tumor angiogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192933&form=6&db=m Regulation of cyclooxygenase isoforms in the renal thick ascending limb: effects of extracellular calcium. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192946&form=6&db=m Helicobacter pylori, gastrin and cyclooxygenases in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11193500&form=6&db=m The role of cyclooxygenase-2 and inflammatory cytokines in pain induction of herniated lumbar intervertebral disc. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11195467&form=6&db=m Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196178&form=6&db=m Expression of cyclooxygenase 2 in human malignant melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11201293&form=6&db=m The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11205258&form=6&db=m Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11206834&form=6&db=m Cyclooxygenase-2 expression in colorectal cancer liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11208460&form=6&db=m Helicobacter pylori, gastrin and cyclooxygenase-2 in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223821&form=6&db=m Expression of cyclooxygenase-2 in human gastric adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11233144&form=6&db=m Reactive nitrogen species in colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11234900&form=6&db=m Cyclooxygenase-2 is overexpressed in human cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238034&form=6&db=m Expression of cyclooxygenase-2 in human transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238189&form=6&db=m Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11239502&form=6&db=m Ajoene, a natural product with non-steroidal anti-inflammatory drug (NSAID)-like properties? causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11241241&form=6&db=m Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245439&form=6&db=m Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: mediation through cyclooxygenase-independent pathways. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11250126&form=6&db=m Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11266376&form=6&db=m Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11270554&form=6&db=m Overexpression of cyclooxygenase-2 in rabbit basilar artery endothelial cells after subarachnoid hemorrhage. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11273781&form=6&db=m Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11274170&form=6&db=m PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11274413&form=6&db=m Deletion of cytosolic phospholipase A(2) suppresses Apc(Min)-induced tumorigenesis. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11275997&form=6&db=m Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278747&form=6&db=m Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11278846&form=6&db=m Selective suppression of CCAAT/enhancer-binding protein beta binding and cyclooxygenase-2 promoter activity by sodium salicylate in quiescent human fibroblasts. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11280748&form=6&db=m Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11280780&form=6&db=m HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11285187&form=6&db=m Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11286825&form=6&db=m Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11289153&form=6&db=m Differential expression of cyclooxygenase-2 and its regulation by tumor necrosis factor-alpha in normal and malignant prostate cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11292836&form=6&db=m Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11295037&form=6&db=m Indomethacin and telomerase activity in tumor growth retardation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11297248&form=6&db=m Overexpression of cyclooxygenase-2 in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11298495&form=6&db=m Trimethyltin-activated cyclooxygenase stimulates tumor necrosis factor-alpha release from glial cells through reactive oxygen species. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11301836&form=6&db=m COX-2 inhibition in clinical cancer prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11302965&form=6&db=m Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11304122&form=6&db=m DNA oxidation induced by cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11306496&form=6&db=m Unusual profile and high prevalence of p53 mutations in esophageal squamous cell carcinomas from northern Iran. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11307496&form=6&db=m [Arachidonic acid and prostaglandins, inflammation and oncology] causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11307497&form=6&db=m [Cyclooxygenases] causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11307498&form=6&db=m [Cyclooxygenase inhibitors] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309214&form=6&db=m Advances in cancer pain management. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309334&form=6&db=m Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11309352&form=6&db=m Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310210&form=6&db=m Interferon-alpha inhibits cyclooxygenase-1 and stimulates cyclooxygenase-2 expression in bladder cancer cells in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310211&form=6&db=m Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313976&form=6&db=m Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316217&form=6&db=m Cyclooxygenase-2 expression in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11320076&form=6&db=m Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11323387&form=6&db=m Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11324321&form=6&db=m [Biological functions of cyclooxygenase 2: control of its expression and activity] causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11324434&form=6&db=m Colorectal cancer and non-steroidal anti-inflammatory drugs. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11325834&form=6&db=m Chemoprevention of colon cancer by a glutathione conjugate of 1,4-phenylenebis(methylene)selenocyanate, a novel organoselenium compound with low toxicity. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11326316&form=6&db=m Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11327079&form=6&db=m Involvement of cyclooxygenase-2 in serum-induced prostaglandin production by human oral gingival epithelial cells. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336563&form=6&db=m Anti-inflammatory drugs, cyclooxygenases and other factors. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342898&form=6&db=m Expression of cyclooxygenase-2 in patients with bladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11344234&form=6&db=m Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11346869&form=6&db=m Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350902&form=6&db=m Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver: possible involvement of COX-2 in the angiogenesis of hepatitis C virus-positive cases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350912&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11356928&form=6&db=m Tumor necrosis factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11370818&form=6&db=m Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375891&form=6&db=m Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11375952&form=6&db=m Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11376495&form=6&db=m Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11381123&form=6&db=m Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11381142&form=6&db=m Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11383452&form=6&db=m [Hormones, autocrine and paracrine regulators of tumor growth in osteosarcoma] causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389054&form=6&db=m Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389063&form=6&db=m Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11397667&form=6&db=m Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401676&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in skin cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11403917&form=6&db=m Inverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11406541&form=6&db=m Cytokine and cyclooxygenase-2 protein in brain areas of tumor-bearing mice with prostanoid-related anorexia. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11407522&form=6&db=m Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11407674&form=6&db=m Present medical management of Barrett's oesophagus. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408945&form=6&db=m Cyclooxygenase-2 expression in normal ovaries and epithelial ovarian neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11410611&form=6&db=m Expression of cyclo-oxygenase-2 in naturally occurring squamous cell carcinomas in dogs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11442675&form=6&db=m Induction of apoptosis by cyclooxygenase-2 inhibitors in prostate cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11443051&form=6&db=m Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11443626&form=6&db=m Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11447830&form=6&db=m Oxidative signalling and inflammatory pathways in Alzheimer's disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448905&form=6&db=m Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11462800&form=6&db=m Neurogenesis and neuroprotection in the adult brain. A putative role for 5-lipoxygenase? causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11465540&form=6&db=m Discovery and design of selective cyclooxygenase-2 inhibitors as non-ulcerogenic, anti-inflammatory drugs with potential utility as anti-cancer agents. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11469677&form=6&db=m Cyclooxygenase-2: a novel target for cancer chemotherapy? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477553&form=6&db=m Cyclooxygenase inhibitors retard murine mammary tumor progression by reducing tumor cell migration, invasiveness and angiogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477578&form=6&db=m Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11490357&form=6&db=m Prostaglandin E2 receptors EP2 and EP4 are down-regulated in human mononuclear cells after injury. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11495083&form=6&db=m Enhanced cyclooxygenase-2 expression in sporadic and familial adenomatous polyposis of the human colon. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11496309&form=6&db=m Cyclooxygenase-2 expression in an adenoid cystic carcinoma of the uterine cervix. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11501838&form=6&db=m Cyclooxygenase-2, P-glycoprotein-170 and drug resistance; is chemoprevention against multidrug resistance possible? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11502467&form=6&db=m The role of cyclooxygenase-2 in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11504793&form=6&db=m Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11506818&form=6&db=m Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11506967&form=6&db=m Inhibitors of cyclooxygenase-2 (COX-2) suppressed the proliferation and differentiation of human leukaemia cell lines. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11507063&form=6&db=m Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11514566&form=6&db=m A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11515678&form=6&db=m Helicobacter pylori infection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11522796&form=6&db=m The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11526505&form=6&db=m Role of cyclic AMP responsive element in the UVB induction of cyclooxygenase-2 transcription in human keratinocytes. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11533708&form=6&db=m NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11535962&form=6&db=m Cancerogenesis in Helicobacter pylori infected stomach--role of growth factors, apoptosis and cyclooxygenases. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11555578&form=6&db=m Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11556546&form=6&db=m Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-kappaB activity and COX-2 transcription in the endothelium of the brain capillaries. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566043&form=6&db=m COX-2 inhibition and prevention of cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566494&form=6&db=m Expression of nitric oxide synthase, cyclooxygenase, and p53 in different stages of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11571629&form=6&db=m Alterations in lipoxygenase and cyclooxygenase-2 catalytic activity and mRNA expression in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11584358&form=6&db=m Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11585770&form=6&db=m Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11586093&form=6&db=m Elevated COX-2 expression in cervical carcinoma: reduced cause-specific survival and pelvic control. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11586094&form=6&db=m Expression of inflammatory modulator COX-2 in pancreatic ductal adenocarcinoma and its relationship to pathologic and clinical parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11586095&form=6&db=m Characterization of the effects of antiangiogenic agents on tumor pathophysiology. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11587078&form=6&db=m Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11592385&form=6&db=m Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595687&form=6&db=m A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595712&form=6&db=m Chronotherapy and chronotoxicity of the cyclooxygenase-2 inhibitor, celecoxib, in athymic mice bearing human breast cancer xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11601879&form=6&db=m Nonsteroidal anti-inflammatory drugs for treatment of advanced gastric cancer: cyclooxygenase-2 is involved in hepatocyte growth factor mediated tumor development and progression. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11602250&form=6&db=m A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11602676&form=6&db=m Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605016&form=6&db=m Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605037&form=6&db=m Cyclooxygenase-2 expression in malignant mesenchymal tumors and related uterine lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605045&form=6&db=m Association between overexpression of cyclooxygenase-2 and suppression of apoptosis in advanced cancer of the uterine cervix after cyclic balloon-occluded arterial infusion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605058&form=6&db=m Cyclooxygenase-2 level and culture conditions influence NS398-induced apoptosis and caspase activation in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11606477&form=6&db=m COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11668514&form=6&db=m Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11673886&form=6&db=m Simultaneous quantification of arachidonic acid metabolites in cultured tumor cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11677654&form=6&db=m Cyclooxygenase-2 (COX-2) enzyme inhibitors as potential enhancers of tumor radioresponse. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687726&form=6&db=m Molecular basis of colorectal cancer - role of gastrin and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687951&form=6&db=m The growth of malignant keratinocytes depends on signaling through the PGE(2) receptor EP1. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687954&form=6&db=m A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11687965&form=6&db=m Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11688844&form=6&db=m Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11689104&form=6&db=m Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11694959&form=6&db=m Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11701743&form=6&db=m Increased expression of cyclooxygenase-2 in malignant pheochromocytomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704632&form=6&db=m COX-2 and cancer: a new approach to an old problem. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11705739&form=6&db=m Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11705852&form=6&db=m Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11708802&form=6&db=m Inhibition of angiogenesis by humulone, a bitter acid from beer hop. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11710598&form=6&db=m Paradoxical effect of aspirin on the growth of C6 rat glioma and on time of development of ENU-induced tumors of the nervous system. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11714866&form=6&db=m Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11721323&form=6&db=m [Effect of nonsteroidal antiinflammatory drugs on colonic lipoxygenase and cyclooxygenase activities from patients with colonic neoplasia] ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11723253&form=6&db=m Conjugated polyhydroxybenzene derivatives block tumor necrosis factor-alpha-mediated nuclear factor-kappaB activation and cyclooxygenase-2 gene transcription by targeting IkappaB kinase activity. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11728453&form=6&db=m Non-steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 expression via repression of transcription in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729113&form=6&db=m Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11729471&form=6&db=m [COX-2 inhibitor and colon cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11733561&form=6&db=m Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11733948&form=6&db=m Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11741744&form=6&db=m Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745262&form=6&db=m COX-2 expression in dysplasia of the head and neck: correlation with elF4E. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745453&form=6&db=m Is COX-2 inhibition a panacea for cancer prevention? causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11748382&form=6&db=m Colon cancer chemoprevention with ginseng and other botanicals. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751373&form=6&db=m Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751448&form=6&db=m Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751489&form=6&db=m Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11754986&form=6&db=m Inflammation, autotoxicity and Alzheimer disease. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11756226&form=6&db=m Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11756433&form=6&db=m Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11758830&form=6&db=m MAPK (ERK2) kinase--a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11763188&form=6&db=m Investigation of mRNA expression of tumor necrosis factor-alpha, interleukin-1beta, and cyclooxygenase-2 in cultured equine digital artery smooth muscle cells after exposure to endotoxin. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11764539&form=6&db=m Prostaglandin inhibitors and the chemoprevention of noncolonic malignancy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11769881&form=6&db=m An introduction to aspirin, NSAIDs, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis: part I. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11769882&form=6&db=m An introduction to aspirin, NSAids, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis: part II. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11774276&form=6&db=m Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779086&form=6&db=m Approach to angiogenesis inhibition based on cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779161&form=6&db=m Prostaglandin E(2) stimulates prostatic intraepithelial neoplasia cell growth through activation of the interleukin-6/GP130/STAT-3 signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781662&form=6&db=m Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782360&form=6&db=m Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782374&form=6&db=m Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11782563&form=6&db=m Endotoxin tolerance: a review. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11785654&form=6&db=m Novel antineoplastic isochalcones inhibit the expression of cyclooxygenase 1,2 and EGF in human prostate cancer cell line LNCaP. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11786771&form=6&db=m Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788675&form=6&db=m Cyclooxygenase-2 expression in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11793368&form=6&db=m Cyclooxygenase-2 expression during carcinogenesis in the human stomach. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11795429&form=6&db=m Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11798601&form=6&db=m [Study on the effect of COX-2's selective inhibitor on human colorectal adenoma cells proliferation] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11807164&form=6&db=m COX-2: a target for colon cancer prevention. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11807649&form=6&db=m Cyclo-oxygenase inhibitors and thromboxane synthase inhibitors differentially regulate migration arrest, growth inhibition and apoptosis in human glioma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809678&form=6&db=m Effects of the cyclooxygenase inhibitor, piroxicam, on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809702&form=6&db=m Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11810043&form=6&db=m Expression of cyclooxygenase-2 is associated with carcinogenesis of the lower part of thoracic esophageal squamous cell carcinoma and p53 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819707&form=6&db=m Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection, histological types and staging. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821123&form=6&db=m Role of melittin-like region within phospholipase A(2)-activating protein in biological function. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11821258&form=6&db=m Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11823979&form=6&db=m Overexpression of cyclo-oxygenase 2 in squamous cell carcinoma of the hypopharynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827414&form=6&db=m Expression of cyclooxygenase-1 and -2 in urinary bladder carcinomas in vivo and in vitro and prostaglandin E2 synthesis in cultured bladder cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830509&form=6&db=m Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11830510&form=6&db=m Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836568&form=6&db=m Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11844819&form=6&db=m Increased cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11849824&form=6&db=m Effects of selective cyclooxygenase enzyme inhibitors on lipopolysaccharide-induced dual thermoregulatory changes in rats. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11850206&form=6&db=m Aromatase and COX-2 expression in human breast cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11851614&form=6&db=m Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853083&form=6&db=m COX-1 and COX-2 expression in osteoid osteomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853685&form=6&db=m Is inhibition of cyclooxygenase required for the anti-tumorigenic effects of nonsteroidal, anti-inflammatory drugs (NSAIDs)? In vitro versus in vivo results and the relevance for the prevention and treatment of cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853703&form=6&db=m Effects of a selective cyclooxygenase-2 inhibitor, celecoxib, on bone resorption and osteoclastogenesis in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854385&form=6&db=m COX-2 inhibitors: cancer trials test new uses for pain drug. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11857443&form=6&db=m Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11872629&form=6&db=m Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11876163&form=6&db=m COX-2 specific inhibitor, NS-398, increases macrophage migration inhibitory factor expression and induces neuroendocrine differentiation in C4-2b prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11881728&form=6&db=m Increased expression of cyclooxygenase-2 in human salivary gland tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11881729&form=6&db=m Immunohistochemical analysis of cyclooxygenase (COX)-2 expression in pancreatic endocrine tumors: association with tumor progression and proliferation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882767&form=6&db=m Prognostic significance of cyclooxygenase 2 mRNA expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882979&form=6&db=m [Osteosarcoma: biochemical and endocrinological studies as a basis for its pathogenetic treatments] causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11888937&form=6&db=m Cyclooxygenase-2 activity altered the cell-surface carbohydrate antigens on colon cancer cells and enhanced liver metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11889377&form=6&db=m Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891188&form=6&db=m Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891209&form=6&db=m Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891406&form=6&db=m Endotoxin tolerance: A review. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11895925&form=6&db=m Exisulind in combination with docetaxel inhibits growth and metastasis of human lung cancer and prolongs survival in athymic nude rats with orthotopic lung tumors. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11900248&form=6&db=m Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11901151&form=6&db=m Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11901304&form=6&db=m COX-2 inhibitors in cancer treatment and prevention, a recent development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11904314&form=6&db=m The effect of selective cyclooxygenase-2 inhibition in Barrett's esophagus epithelium: an in vitro study. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11905709&form=6&db=m Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11906190&form=6&db=m Expression profile analysis of colon cancer cells in response to sulindac or aspirin. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11910360&form=6&db=m Chemoprevention of esophageal adenocarcinoma by COX-2 inhibitors in an animal model of Barrett's esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11912139&form=6&db=m Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11917224&form=6&db=m Expression of COX-2, Ki-67, cyclin D1, and P21 in endometrial endometrioid carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920515&form=6&db=m Immunohistochemical analysis and in situ hybridization of cyclooxygenase-2 expression in intraductal papillary-mucinous tumors of the pancreas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920595&form=6&db=m Expression of cyclooxygenase-2 in the subserosal layer correlates with postsurgical prognosis of pathological tumor stage 2 carcinoma of the gallbladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11929821&form=6&db=m Celecoxib exhibits the greatest potency amongst cyclooxygenase (COX) inhibitors for growth inhibition of COX-2-negative hematopoietic and epithelial cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11939728&form=6&db=m Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943943&form=6&db=m Cyclooxygenase-2 expression in early gastric cancer, intestinal metaplasia and Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943946&form=6&db=m Cyclooxygenase-2 expression is increased in early intestinal-type gastric cancer and gastric mucosa with intestinal metaplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11945149&form=6&db=m COX selectivity and animal models for colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11945150&form=6&db=m The role of cyclooxygenase inhibitors in cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11948128&form=6&db=m Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11953864&form=6&db=m Inhibitor of cyclooxygenase-2 induces cell-cycle arrest in the epithelial cancer cell line via up-regulation of cyclin dependent kinase inhibitor p21. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11956094&form=6&db=m Selective cyclooxygenase (COX)-1 or COX-2 inhibitors control metastatic disease in a murine model of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11957147&form=6&db=m Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11965228&form=6&db=m Celecoxib: a specific COX-2 inhibitor with anticancer properties. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966530&form=6&db=m Review article: COX-2, prostanoids and colon cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11969234&form=6&db=m The role of nutrition and chemoprevention in colorectal cancer: from observations to expectations. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11970975&form=6&db=m Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11972392&form=6&db=m Cyclooxygenase-2 (COX-2), epidermal growth factor receptor (EGFR), and Her-2/neu expression in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11980643&form=6&db=m Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11981761&form=6&db=m Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11989839&form=6&db=m Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11991627&form=6&db=m Mechanisms involved in the attenuation of intestinal toxicity induced by (S)-(+)-ketoprofen in re-fed rats. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11991685&form=6&db=m Inhibition of tumor angiogenesis by non-steroidal anti-inflammatory drugs: emerging mechanisms and therapeutic perspectives. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11992750&form=6&db=m Screening for colon cancer and evaluation of chemoprevention with coxibs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994539&form=6&db=m FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12000750&form=6&db=m Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12003384&form=6&db=m Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009007&form=6&db=m Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011226&form=6&db=m DNA methylation and environmental exposures in human hepatocellular carcinoma. diagnostic usage,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12011987&form=6&db=m Chemoprevention of breast cancer by targeting cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma (Review). causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12012021&form=6&db=m A new ditriazine inhibitor of NF-kappaB modulates chronic inflammation and angiogenesis. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12014312&form=6&db=m Gastric MALT-lymphoma, gastrin and cyclooxygenases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12014863&form=6&db=m Celecoxib with chemotherapy in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12016152&form=6&db=m Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020636&form=6&db=m Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12024286&form=6&db=m Cyclooxygenase-2 expression in pediatric sarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12042461&form=6&db=m Red wine and black tea polyphenols modulate the expression of cycloxygenase-2, inducible nitric oxide synthase and glutathione-related enzymes in azoxymethane-induced f344 rat colon tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12046075&form=6&db=m Effect of nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12049307&form=6&db=m Comparison of cyclo-oxygenase 2 expression in colorectal serrated adenomas to expression in tubular adenomas and hyperplastic polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12049957&form=6&db=m Comparing contrast-enhanced ultrasound to immunohistochemical markers of angiogenesis in a human melanoma xenograft model: preliminary results. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12051953&form=6&db=m Characterization of cyclooxygenase-2 (COX-2) during tumorigenesis in human epithelial cancers: evidence for potential clinical utility of COX-2 inhibitors in epithelial cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12051958&form=6&db=m PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060628&form=6&db=m Cyclooxygenase-2 expression is a novel prognostic factor in malignant mesothelioma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12060668&form=6&db=m Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12062631&form=6&db=m Role of Kupffer cells in alcoholic hepatitis. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12063562&form=6&db=m Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065309&form=6&db=m Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066205&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12066226&form=6&db=m Synergistic interaction between highly specific cyclooxygenase-2 inhibitor, MF-tricyclic and lovastatin in murine colorectal cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12067981&form=6&db=m Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070598&form=6&db=m Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12074318&form=6&db=m Reducing the risk of colorectal cancer by intervening in the process of carcinogenesis: a status report. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12075734&form=6&db=m Cyclooxygenase-2 (COX-2), aromatase and breast cancer: a possible role for COX-2 inhibitors in breast cancer chemoprevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12085962&form=6&db=m Role of eicosanoids in prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086399&form=6&db=m Effects of yakuchinone A and yakuchinone B on the phorbol ester-induced expression of COX-2 and iNOS and activation of NF-kappaB in mouse skin. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086400&form=6&db=m Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophage cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086404&form=6&db=m Increased expression of COX-2 in the development of human lung cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086405&form=6&db=m Is cyclooxygenase-2 important in skin carcinogenesis? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086406&form=6&db=m Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086407&form=6&db=m Prostaglandins and the regulation of tumor growth. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12088280&form=6&db=m Cyclooxygenase, lipoxygenase and tumor angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12089724&form=6&db=m Cyclooxygenase-2 (COX-2) expression by immunohistochemistry in glioblastoma multiforme. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102578&form=6&db=m Potential role of selective COX-2 inhibitors in cancer management. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12102579&form=6&db=m Current application of selective COX-2 inhibitors in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12107271&form=6&db=m Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12109806&form=6&db=m Preoperative chemoradiation for locally advanced rectal cancer: emerging treatment strategies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12110643&form=6&db=m Cyclooxygenase-2 overexpression in colorectal cancer is associated with non-polypoid growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12113880&form=6&db=m Interferon gamma antagonizes interleukin-1beta-induced cyclooxygenase-2 expression and prostaglandin E(2) production in human myometrial cells. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12123737&form=6&db=m Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124326&form=6&db=m Cyclooxygenase-2 inhibitor treatment enhances photodynamic therapy-mediated tumor response. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124799&form=6&db=m Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124807&form=6&db=m Inflammation and cancer, the mastocytoma P815 tumor model revisited: triggering of macrophage activation in vivo with pro-tumorigenic consequences. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126145&form=6&db=m Cyclooxygenase-2 expression in spontaneous intestinal neoplasia of domestic dogs. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12127122&form=6&db=m Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12130685&form=6&db=m Transcriptional regulation of basal cyclooxygenase-2 expression in murine lung tumor-derived cell lines by CCAAT/enhancer-binding protein and activating transcription factor/cAMP response element-binding protein. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12138126&form=6&db=m Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12138405&form=6&db=m A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12142058&form=6&db=m Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition. identification of novel chemotherapeutic drug resistance modulators. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12143044&form=6&db=m Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12143054&form=6&db=m ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12144866&form=6&db=m Prostate cancer vs hyperplasia: relationships with prostatic and adipose tissue fatty acid composition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12144946&form=6&db=m PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12145811&form=6&db=m Lipopolysaccharide preconditioning and cross-tolerance: the induction of protective mechanisms for rat intestinal ileus. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12154043&form=6&db=m Piroxicam is an ineffective inhibitor of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12162677&form=6&db=m Cyclooxygenase 2 expression in pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia: an immunohistochemical analysis with automated cellular imaging. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12162776&form=6&db=m Inducible cyclooxygenase and interleukin 6 gene expressions in nasal polyp fibroblasts: possible implication in the pathogenesis of nasal polyposis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164968&form=6&db=m Role of cyclooxygenase-2 and inducible nitric oxide synthase in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12165078&form=6&db=m Metallothionein suppresses collagen-induced arthritis via induction of TGF-beta and down-regulation of proinflammatory mediators. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12168930&form=6&db=m COX-2 expression in rectal carcinoma: immunohistochemical pattern and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173384&form=6&db=m Expression of cyclooxygenase-2 in primary and remnant gastric carcinoma: comparing it with p53 accumulation, Helicobacter pylori infection, and vascular endothelial growth factor expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12174888&form=6&db=m Increased cyclooxygenase-2 expression in human squamous cell carcinomas of the head and neck and inhibition of proliferation by nonsteroidal anti-inflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12175542&form=6&db=m FA15, a hydrophobic derivative of ferulic acid, suppresses inflammatory responses and skin tumor promotion: comparison with ferulic acid. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12181243&form=6&db=m Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12189197&form=6&db=m Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12195185&form=6&db=m Cyclooxygenase-2 inhibition augments the hepatic antitumor effect of oral Salmonella typhimurium in a model of mouse metastatic colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196922&form=6&db=m Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12197220&form=6&db=m Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12199620&form=6&db=m Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12201625&form=6&db=m The mRNA expression of cyclo-oxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203806&form=6&db=m Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204102&form=6&db=m Activation of adherent vascular neutrophils in the lung during acute endotoxemia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12208739&form=6&db=m Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209724&form=6&db=m Cyclooxygenase-2 expression in endometrial carcinoma: correlation with clinicopathologic parameters and clinical outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12209745&form=6&db=m Overexpression of cyclooxygenase-2 is associated with a poor prognosis in patients with squamous cell carcinoma of the uterine cervix treated with radiation and concurrent chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12215492&form=6&db=m Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-binding protein-delta and peroxisome proliferator-activated receptor-gamma. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12217640&form=6&db=m Antiangiogenic effect of a highly selective cyclooxygenase-2 inhibitor on gastric ulcer healing in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12221288&form=6&db=m Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12230110&form=6&db=m Expression of cyclooxygenase-2 and pro-inflammatory cytokines induced by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) in human mast cells requires NF-kappa B activation. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12234478&form=6&db=m Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237848&form=6&db=m Transforming growth factor beta1 prevents IL-1beta-induced microglial activation, whereas TNFalpha- and IL-6-stimulated activation are not antagonized. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12269772&form=6&db=m Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12270500&form=6&db=m The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297112&form=6&db=m Recombinant glucocorticoid induced tumour necrosis factor receptor (rGITR) induced COX-2 activity in murine macrophage Raw 264.7 cells. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297183&form=6&db=m Adenoid cystic carcinoma of the trachea and bronchus--a clinicopathologic study with DNA flow cytometric analysis and oncogene expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297835&form=6&db=m Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12349897&form=6&db=m Tumor necrosis factor alpha (TNF-alpha)-induced prostaglandin E2 release is mediated by the activation of cyclooxygenase-2 (COX-2) transcription via NFkappaB in human gingival fibroblasts. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12352459&form=6&db=m Prostaglandin E2 production and cyclooxygenase-2 induction in human urinary tract infections and bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12353842&form=6&db=m Progastrin and cyclooxygenase-2 in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12359744&form=6&db=m Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12360423&form=6&db=m Cyclooxygenase-2 and ERBB-2 in cholangiocarcinoma: potential therapeutic targets. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12364744&form=6&db=m Decrease of proinflammatory molecules correlates with neuroprotective effect of the fluorinated salicylate triflusal after postnatal excitotoxic damage. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369871&form=6&db=m Selective cyclooxygenase-2 inhibitors and non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12370807&form=6&db=m Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12376474&form=6&db=m Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12377342&form=6&db=m In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerations. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384076&form=6&db=m Modulation of lipopolysaccharide-stimulated macrophage tumor necrosis factor-alpha production by omega-3 fatty acid is associated with differential cyclooxygenase-2 protein expression and is independent of interleukin-10. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384538&form=6&db=m Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384795&form=6&db=m The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384982&form=6&db=m Calcium-independent phospholipase A2 through arachidonic acid mobilization is involved in Caco-2 cell growth. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12386924&form=6&db=m Cyclooxygenase-2 promotes prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12387716&form=6&db=m Arachidonic acid metabolism in growth control of A549 human lung adenocarcinoma cells. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12390516&form=6&db=m Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12391285&form=6&db=m Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393863&form=6&db=m Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393872&form=6&db=m Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12400684&form=6&db=m Anticoagulant from Taraxacum platycarpum. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12401798&form=6&db=m Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12402155&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in tumour and stroma compartments in cervical cancer: clinical implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12405290&form=6&db=m Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12408376&form=6&db=m Cyclooxygenase inhibitors block cell growth, increase ceramide and inhibit cell cycle. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12411406&form=6&db=m Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413723&form=6&db=m Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12417996&form=6&db=m Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421501&form=6&db=m [Antisense inhibition of cyclooxygenase-2 reduces malignant phenotype of gastric cancer cells] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421878&form=6&db=m Omega-3 fatty acids to augment cancer therapy. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429306&form=6&db=m Association of cyclooxygenase-2 expression with prognosis of stage T1 grade 3 bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429721&form=6&db=m TNF-related apoptosis-inducing ligand (TRAIL) up-regulates cyclooxygenase (COX)-1 activity and PGE(2) production in cells of the myeloid lineage. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432918&form=6&db=m Cyclooxygenases and colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12433707&form=6&db=m Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12433932&form=6&db=m NS-398 and piroxicam suppress UVB-induced activator protein 1 activity by mechanisms independent of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12434411&form=6&db=m Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12438270&form=6&db=m Direct evidence for a role of cyclooxygenase 2-derived prostaglandin E2 in human head and neck xenograft tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12440624&form=6&db=m The role of COX-2 inhibitors in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12442003&form=6&db=m Synergistic cytotoxicity and apoptosis of JTE-522, a selective cyclooxygenase-2 inhibitor, and 5-fluorouracil against bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12444039&form=6&db=m Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12445196&form=6&db=m Cyclooxygenase-2 inhibitor enhances whereas prostaglandin E2 inhibits the production of interferon-induced protein of 10 kDa in epidermoid carcinoma A431. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12445672&form=6&db=m Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12447099&form=6&db=m COX-2 inhibitors and their role in gynecology. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452062&form=6&db=m [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452063&form=6&db=m [Influence of selective cyclooxygenase-2 inhibitor on proliferation of human gastric cancer cells] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12455057&form=6&db=m Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12457435&form=6&db=m Cyclooxygenase 2 selective inhibitors in cancer treatment and prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12459168&form=6&db=m Correlation between nitric oxide and cyclooxygenase-2 pathways in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460897&form=6&db=m Cyclooxygenase-2 expression in fibroblasts and endothelial cells of intestinal polyps. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460898&form=6&db=m Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12464646&form=6&db=m Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468265&form=6&db=m Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by conjugated linoleic acid in murine macrophages. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468543&form=6&db=m Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12468643&form=6&db=m Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470437&form=6&db=m Anticancer activity of Scutellaria baicalensis and its potential mechanism. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12470662&form=6&db=m Cyclooxygenase-2 increased the angiogenic and metastatic potential of tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12471036&form=6&db=m Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12472107&form=6&db=m Role of cyclooxygenase-2 in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12483244&form=6&db=m Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12485462&form=6&db=m Chemopreventive effect of celecoxib and expression of cyclooxygenase-1 and cyclooxygenase-2 on chemically-induced rat mammary tumours. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12485854&form=6&db=m Induction of cyclooxygenase-2 in Ras-transformed human mammary epithelial cells undergoing apoptosis. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12487927&form=6&db=m [Relationship between cyclooxygenase-2 protein expression, prostaglandins levels and biologic behavior in ovarian carcinoma tissue] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12488433&form=6&db=m The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12490541&form=6&db=m Impaired monocyte function in cancer patients: restoration with a cyclooxygenase-2 inhibitor. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12491803&form=6&db=m [COX inhibitor, suppression of polyposis, and chemoprevention] causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12494894&form=6&db=m COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12496057&form=6&db=m Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499278&form=6&db=m Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499282&form=6&db=m Insulin-like growth factor-I antagonizes the antiproliferative effects of cyclooxygenase-2 inhibitors on BxPC-3 pancreatic cancer cells. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499915&form=6&db=m The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504031&form=6&db=m High cyclooxygenase-2 expression is related with distant metastasis in cervical cancer treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504032&form=6&db=m Cyclooxygenase-2 (COX-2) expression in locally advanced cervical cancer patients undergoing chemoradiation plus surgery. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504222&form=6&db=m Selective cyclooxygenase-2 inhibitor rofecoxib (Vioxx) induces expression of cell cycle arrest genes and slows tumor growth in human pancreatic cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507282&form=6&db=m A COX-2 inhibitor, nimesulide, inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and iNOS expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12507933&form=6&db=m Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12509799&form=6&db=m Chemoradiotherapy: emerging treatment improvement strategies. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12511556&form=6&db=m Cyclooxygenase-2 inhibits tumor necrosis factor alpha-mediated apoptosis in renal glomerular mesangial cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12516959&form=6&db=m Deregulated cyclooxygenase-2 expression in oral premalignant tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12517588&form=6&db=m Uterine leiomyomas express myometrial contractile-associated proteins involved in pregnancy-related hormone signaling. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12520638&form=6&db=m Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523457&form=6&db=m Selective cyclooxygenase-2 inhibition: a target in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12523498&form=6&db=m The expression of cyclooxygenase-1 and -2 in proliferative endometrium and endometrial adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12526218&form=6&db=m [Expression of cyclooxygenase-2 in human transitional cell bladder carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12528468&form=6&db=m [Prostaglandin E2 synthases] causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12532441&form=6&db=m Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12533667&form=6&db=m Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12534075&form=6&db=m [A new drug approach approved in the USA. Cox-2 inhibitor in intestinal cancer] therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12535526&form=6&db=m Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12538661&form=6&db=m Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12543811&form=6&db=m Cyclooxygenase-2 expression and prostanoid biogenesis reflect clinical phenotype in human colorectal fibroblast strains. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12559775&form=6&db=m Cyclooxygenase 2: a molecular target for cancer prevention and treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12560924&form=6&db=m Increased cyclooxygenase-2 expression in large flat colorectal tumors (laterally spreading tumors). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12566300&form=6&db=m Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12569549&form=6&db=m A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12573534&form=6&db=m Hypothermia suppresses inducible nitric oxide synthase and stimulates cyclooxygenase-2 in lipopolysaccharide stimulated BV-2 cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576442&form=6&db=m Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576525&form=6&db=m Role of cyclooxygenases COX-1 and COX-2 in modulating adipogenesis in 3T3-L1 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576817&form=6&db=m Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12578839&form=6&db=m Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12579257&form=6&db=m Reduction of dihydrodiol dehydrogenase expression in resected hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12579269&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 and vascular endothelial growth factor in pancreaticobiliary maljunction. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12581424&form=6&db=m Reduction of scar formation in full-thickness wounds with topical celecoxib treatment. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12582422&form=6&db=m The basis for the chemopreventive action of resveratrol. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12583990&form=6&db=m Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12584182&form=6&db=m Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12586778&form=6&db=m Decreased expression of tumor necrosis factor-alpha-stimulated gene 6 in cumulus cells of the cyclooxygenase-2 and EP2 null mice. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12588370&form=6&db=m Selective cyclooxygenase-2 inhibition does not affect the healing of cutaneous full-thickness incisional wounds in SKH-1 mice. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12589035&form=6&db=m Effects of the cyclooxygenase inhibitor, piroxicam, in combination with chemotherapy on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591723&form=6&db=m Abnormal interleukin 10Ralpha expression contributes to the maintenance of elevated cyclooxygenase-2 in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12591965&form=6&db=m COX-2, inflammatory secreted PLA2, and cytoplasmic PLA2 protein expression in small bowel adenocarcinomas compared with colorectal adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12592098&form=6&db=m Cyclooxygenase-2 expression is associated with well-differentiated and intestinal-type pathways in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12592372&form=6&db=m Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12596063&form=6&db=m Expression of cyclo-oxygenase-2 is correlated with high intratumoral microvessel density and low apoptotic index in human esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12598658&form=6&db=m Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12604364&form=6&db=m 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12614262&form=6&db=m Overexpression of cyclooxygenase-2 in high-grade human transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12615701&form=6&db=m Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12616113&form=6&db=m Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12618325&form=6&db=m Cyclooxygenase-2 and prostate carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12621392&form=6&db=m Influence of willow bark extract on cyclooxygenase activity and on tumor necrosis factor alpha or interleukin 1 beta release in vitro and ex vivo. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622174&form=6&db=m Phospholipase A2-activating protein--an important regulatory molecule in modulating cyclooxygenase-2 and tumor necrosis factor production during inflammation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12622426&form=6&db=m Expression of cyclooxygenase-2 protein in colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12626523&form=6&db=m Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628505&form=6&db=m Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12629931&form=6&db=m Cyclooxygenase-2: from arthritis treatment to new indications for the prevention and treatment of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631593&form=6&db=m Tumor cyclooxygenase 2-dependent suppression of dendritic cell function. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12631609&form=6&db=m Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12633561&form=6&db=m Cyclooxygenase-2 in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12636104&form=6&db=m An immunohistochemical study of cyclooxygenase (COX)-2 expression in endocrine tumors of the pancreas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637635&form=6&db=m Glucose degradation products increase apoptosis of human mesothelial cells. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637762&form=6&db=m Cyclooxygenase-2 expression in canine mammary tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12646969&form=6&db=m [NSAIDs caused gastric mucosal injury: with a special reference to COX-2] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12647960&form=6&db=m Gene expression of immunologically important factors in blood cells, milk cells, and mammary tissue of cows. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648590&form=6&db=m High cyclooxygenase-2 expression in cervical adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648598&form=6&db=m Inhibition of paclitaxel-induced apoptosis by the specific COX-2 inhibitor, NS398, in epithelial ovarian cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12650831&form=6&db=m Prostaglandin F(2alpha) stimulation of cyclooxygenase-2 promoter activity by the FP(B) prostanoid receptor. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12660005&form=6&db=m Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664583&form=6&db=m Cyclooxygenase-2 in human pathological disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664616&form=6&db=m Cyclooxygenase-2 induction in rat spinal cord injury mediated by proinflammatory tumor necrosis factor-alpha and interleukin-1. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664624&form=6&db=m Cyclooxygenase-2: a molecular target for chemoprevention of epithelial tumors of skin and colon. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12665651&form=6&db=m An immunohistochemical survey of nine cases of medullary carcinoma of thyroid including reactivity for Cox-1 and Cox-2 enzymes. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12667327&form=6&db=m [Clinicopathologic significance of cyclooxygenase-2 mRNA expression in human breast carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12669881&form=6&db=m Proinflammatory cytokines induce cyclooxygenase-2 mRNA and protein expression in human pulp cell cultures. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12670347&form=6&db=m Induction of cyclooxygenase-1 and -2 modulates angiogenic responses to engagement of alphavbeta3. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12674216&form=6&db=m Influence of gastrin on the expression of cyclooxygenase-2, hepatocyte growth factor and apoptosis-related proteins in gastric epithelial cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12676044&form=6&db=m Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679317&form=6&db=m Cyclooxygenase-2 inhibition improves macrophage function in melanoma and increases the antineoplastic activity of interferon gamma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679640&form=6&db=m Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679908&form=6&db=m Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12680220&form=6&db=m The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684433&form=6&db=m Combination of a selective cyclooxygenase-2 inhibitor with epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686777&form=6&db=m Expression of COX-2 in stomach cancers and its relation to their biological features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12692419&form=6&db=m Expression of cyclooxygenase-2 and its correlation with clinicopathologic factors of ampulla of vater cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12698187&form=6&db=m Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12703120&form=6&db=m [Selective cyclooxygenase-2 inhibitors and the digestive tract] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12705063&form=6&db=m [Epidemiological studies for evaluating the role of cyclooxygenase in chemoprevention of malignant tumors] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12706854&form=6&db=m Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12708493&form=6&db=m Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12711327&form=6&db=m C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713622&form=6&db=m Cyclooxygenase-2 is expressed frequently and early in Barrett's oesophagus and associated adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713627&form=6&db=m Cyclooxygenase-2 expression in thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12718676&form=6&db=m NSAIDs as Cancer Preventive Agents. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12720152&form=6&db=m Potential new therapeutics for Waldenstrom's macroglobulinemia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12720297&form=6&db=m Variation in cyclooxygenase expression levels within the colorectum. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12724337&form=6&db=m Does the release of arachidonic acid from cells play a role in cancer chemoprevention? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727794&form=6&db=m Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12727848&form=6&db=m Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730704&form=6&db=m Selective COX-2 inhibitors as chemopreventive and therapeutic agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730870&form=6&db=m Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730872&form=6&db=m A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730964&form=6&db=m Oncostatin M enhances the expression of prostaglandin E2 and cyclooxygenase-2 in astrocytes: synergy with interleukin-1beta, tumor necrosis factor-alpha, and bacterial lipopolysaccharide. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12735864&form=6&db=m Expression of cyclooxygenase-2 in rat testis. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738712&form=6&db=m Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738729&form=6&db=m Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738747&form=6&db=m The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12743436&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in gastric hyperplastic polyp--association with polyp size. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12746218&form=6&db=m Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12747975&form=6&db=m Cyclooxygenase-2 (COX-2) expression in high-risk premalignant oral lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12748469&form=6&db=m Expression of cyclooxygenase-2 in cervical, endometrial, and ovarian malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750248&form=6&db=m Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12751757&form=6&db=m Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12753878&form=6&db=m Potential effect of cyclooxygenase-2-specific inhibitors on the prevention of colorectal cancer: a cost-effectiveness analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12757841&form=6&db=m Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12759338&form=6&db=m Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767075&form=6&db=m Increased toxicity and lack of efficacy of Rofecoxib in combination with chemotherapy for treatment of metastatic colorectal cancer: A phase II study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767095&form=6&db=m Cyclooxygenase-2 expression in human pituitary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767510&form=6&db=m Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767532&form=6&db=m Orthotopic implantation of a colon cancer xenograft induces high expression of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767686&form=6&db=m Enhancement of carcinogen-induced malignant cell transformation by prostaglandin F(2 alpha). causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767718&form=6&db=m Herbal medicine, cancer prevention and cyclooxygenase 2 inhibition. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12769697&form=6&db=m The medicinal chemistry implications of the anticancer effects of aspirin and other NSAIDs. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12771040&form=6&db=m Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12771797&form=6&db=m Cyclooxygenase-2 as a potential target in the prevention and treatment of genitourinary tumors: a review. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12771929&form=6&db=m Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12774242&form=6&db=m Cyclo-oxygenase 2 inhibitors: emerging roles in the gut. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12775118&form=6&db=m Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12777984&form=6&db=m Cyclooxygenase-2 promoter for tumour-specific targeting of adenoviral vectors to melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12778076&form=6&db=m Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12781633&form=6&db=m A wholly nutritional 'multifocal angiostatic therapy' for control of disseminated cancer. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12784332&form=6&db=m Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12789263&form=6&db=m Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795048&form=6&db=m Regulation of COX-2 expression in human cancers. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795051&form=6&db=m Cyclooxygenase-2: a target for the prevention and treatment of cancers of the upper digestive tract. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795055&form=6&db=m Therapeutic potential of selective cyclooxygenase-2 inhibitors in the management of tumor angiogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795056&form=6&db=m Potential for combined modality therapy of cyclooxygenase inhibitors and radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795455&form=6&db=m Pioglitazone, a specific ligand of the peroxisome proliferator-activated receptor gamma reduces gastric mucosal injury induced by ischaemia/ reperfusion in rat. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12797548&form=6&db=m Rho protein inhibition blocks cyclooxygenase-2 expression by proinflammatory mediators in endothelial cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12797681&form=6&db=m Management of Barrett's esophagus with and without dysplasia. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12798395&form=6&db=m Carcinogenesis and cyclooxygenase: the potential role of COX-2 inhibition in upper aerodigestive tract cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12800231&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12800601&form=6&db=m Improvement of radiotherapy or chemoradiotherapy by targeting COX-2 enzyme. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12802790&form=6&db=m Cyclooxygenase-2 inhibitors in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12810622&form=6&db=m Cyclooxygenase-2 expression and effect of celecoxib in gastric adenomas of trefoil factor 1-deficient mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811205&form=6&db=m Cyclooxygenase-2 overexpression correlates with vascular endothelial growth factor expression and tumor angiogenesis in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811209&form=6&db=m Poor prognosis of colorectal cancer in patients over 80 years old is associated with down-regulation of tumor suppressor genes. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12814192&form=6&db=m A novel embedment-free immunoelectron microscopy technique reveals association of apoptosis-regulating proteins with subcellular structures. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12814542&form=6&db=m Role of COX-2 specific inhibitors in oncogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12819026&form=6&db=m Identification of novel cellular targets in biliary tract cancers using global gene expression technology. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821125&form=6&db=m PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821346&form=6&db=m Expression of cyclooxygenase-1 and -2 associated with expression of VEGF in primary cervical cancer and at metastatic lymph nodes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821538&form=6&db=m Cyclooxygenase-2 in human and experimental ischemic proliferative retinopathy. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12823157&form=6&db=m Effect of cyclooxygenase-2 inhibition on human Helicobacter pylori gastritis: mechanisms underlying gastrointestinal safety and implications for cancer chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824303&form=6&db=m Celecoxib activates a novel mitochondrial apoptosis signaling pathway. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824517&form=6&db=m Cyclooxygenase-1 and -2 expression in urothelial carcinomas of the urinary bladder in cows. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12824918&form=6&db=m Colon cancer cells with high invasive potential are susceptible to induction of apoptosis by a selective COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829126&form=6&db=m Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12837940&form=6&db=m Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839690&form=6&db=m [Relation between COX-2 protein expression and biologic behavior of ovarian carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839936&form=6&db=m Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12839952&form=6&db=m Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12841340&form=6&db=m Regulation of cytosolic phospholipase A2, cyclooxygenase-1 and -2 expression by PMA, TNFalpha, LPS and M-CSF in human monocytes and macrophages. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12843292&form=6&db=m Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12845964&form=6&db=m Cyclooxygenase-2 expression correlates with nuclear p53 accumulation in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12855643&form=6&db=m Correlation between cyclooxygenase-2 expression and angiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12857884&form=6&db=m ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12867070&form=6&db=m Targeted therapies for stage III non-small cell lung cancer: integration in the combined modality setting. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12870656&form=6&db=m Modulation of annexin I and cyclooxygenase-2 in smokeless tobacco-induced inflammation and oral cancer. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871081&form=6&db=m New targets for the modulation of radiation response--selective inhibition of the enzyme cyclooxygenase 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871756&form=6&db=m Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871860&form=6&db=m p38 MAPK and NF-kappaB mediate COX-2 expression in human airway myocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12873979&form=6&db=m Association between Cyclooxygenase expression and colorectal adenoma characteristics. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12874281&form=6&db=m Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12875991&form=6&db=m Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12879127&form=6&db=m Defining the role of COX-2 inhibitors in inflammatory and other diseases. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12879280&form=6&db=m Metronomic oral low-dose treosulfan chemotherapy combined with cyclooxygenase-2 inhibitor in pretreated advanced melanoma: a pilot study. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12882963&form=6&db=m p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883469&form=6&db=m H. pylori infection, atrophic gastritis, cytokines, gastrin, COX-2, PPAR gamma and impaired apoptosis in gastric carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883661&form=6&db=m Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883688&form=6&db=m Role of COX-2, VEGF and cyclin D1 in mammary infiltrating duct carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12884024&form=6&db=m Analysis of cyclooxygenase-2 expression in human breast cancer: high throughput tissue microarray analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12885872&form=6&db=m Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12890694&form=6&db=m The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891542&form=6&db=m The cyclooxygenase-2-selective inhibitors rofecoxib and celecoxib prevent colorectal neoplasia occurrence and recurrence. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12892443&form=6&db=m The overexpression of cyclo-oxygenase-2 in chronic periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12894507&form=6&db=m The effect of cyclooxygenase inhibitor diclofenac on experimental murine colon carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12894587&form=6&db=m Epstein-Barr virus induces invasion and metastasis factors. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895344&form=6&db=m [Overexpression of COX-2 and its clinical significance in non-small cell lung cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895350&form=6&db=m [Expression of the cyclooxygenase-2 gene in human breast carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12898538&form=6&db=m Administration of the p38 MAPK inhibitor SB203580 affords brain protection with a wide therapeutic window against focal ischemic insult. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12901877&form=6&db=m PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12901883&form=6&db=m Chitosan inhibits prostaglandin E2 formation and cyclooxygenase-2 induction in lipopolysaccharide-treated RAW 264.7 macrophages. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12901943&form=6&db=m Cyclooxygenase inhibitors: drugs for cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902324&form=6&db=m Myeloid differentiation factor 88-dependent post-transcriptional regulation of cyclooxygenase-2 expression by CpG DNA: tumor necrosis factor-alpha receptor-associated factor 6, a diverging point in the Toll-like receptor 9-signaling. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902854&form=6&db=m Proceedings of the RTOG (Radiation Therapy Oncology Group) Symposium: COX-2 Inhibitors and Cancer Therapeutics. June 2001. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902855&form=6&db=m COX-2 inhibitors and cancer therapeutics: potential roles for inhibitors of COX-2 in combination with cytotoxic therapy: reports from a symposium held in conjunction with the Radiation Therapy Oncology Group June 2001 Meeting. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902857&form=6&db=m COX-2 inhibitors as radiosensitizing agents for cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902859&form=6&db=m Cyclooxygenase-2 (COX-2) enzyme inhibitors and radiotherapy: preclinical basis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902860&form=6&db=m COX-2 inhibitor as a radiation enhancer: new strategies for the treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902861&form=6&db=m Cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) expression in human pituitary macroadenomas. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902862&form=6&db=m Initial experience combining cyclooxygenase-2 inhibition with chemoradiation for locally advanced pancreatic cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902863&form=6&db=m Combination of a COX-2 inhibitor with radiotherapy or radiochemotherapy in the treatment of thoracic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902864&form=6&db=m Effect of the combination of docetaxel, zoledronic acid, and a COX-2 inhibitor on the growth of human breast cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902865&form=6&db=m Cyclooxygenase-2 (COX-2) expression in human meningioma as a function of tumor grade. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902866&form=6&db=m Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902867&form=6&db=m COX-2 inhibitors as radiation sensitizers for upper GI tract cancers: esophagus, stomach, and pancreas. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902868&form=6&db=m Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902869&form=6&db=m Why cyclooxygenase-2 inhibition plus chemotherapy? causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12903842&form=6&db=m Mouse skin as a model for cancer chemoprevention by nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12905826&form=6&db=m [Non-steroidal anti-inflammatory drugs and chemoprevention of digestive cancer] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12906745&form=6&db=m Rofecoxib: an update on physicochemical, pharmaceutical, pharmacodynamic and pharmacokinetic aspects. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907138&form=6&db=m Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12908559&form=6&db=m Cyclooxygenase-2 inhibitors in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12910508&form=6&db=m Hepatocellular carcinoma: is there a potential for chemoprevention using cyclooxygenase-2 inhibitors? causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12912810&form=6&db=m Dual functionality of cyclooxygenase-2 as a regulator of tumor necrosis factor-mediated G1 shortening and nitric oxide-mediated inhibition of vascular smooth muscle cell proliferation. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12912858&form=6&db=m Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12913755&form=6&db=m Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12921553&form=6&db=m [Inhibitory effect of NS398 on the proliferation of human ovarian cancer cell lines CAOV3 and OVCAR3 in vitro] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12925310&form=6&db=m Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926055&form=6&db=m Expression of cyclooxygenase-2 in malignant and benign breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12929571&form=6&db=m Combination chemotherapy with JTE-522, a novel selective cyclooxygenase-2 inhibitor, and cisplatin against gastric cancer cell lines in vitro and in vivo. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12930301&form=6&db=m Involvement of EGF receptor activation in the induction of cyclooxygenase-2 in HaCaT keratinocytes after UVB. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12930427&form=6&db=m Cyclooxygenase-2 promotes angiogenesis in pTa/T1 urothelial bladder carcinoma but does not predict recurrence. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12935909&form=6&db=m Abietic acid activates peroxisome proliferator-activated receptor-gamma (PPARgamma) in RAW264.7 macrophages and 3T3-L1 adipocytes to regulate gene expression involved in inflammation and lipid metabolism. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12937850&form=6&db=m Administration of liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE) and diclofenac in the combination attenuates their anti-tumor activities. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941199&form=6&db=m New targeted therapies in gastrointestinal cancers. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941808&form=6&db=m Cooperation of cyclooxygenase 1 and cyclooxygenase 2 in intestinal polyposis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941827&form=6&db=m Ski-related novel protein N (SnoN), a negative controller of transforming growth factor-beta signaling, is a prognostic marker in estrogen receptor-positive breast carcinomas. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12945071&form=6&db=m Cyclo-oxygenase 2 inhibition in colorectal cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12946449&form=6&db=m Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human neutrophils. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12948419&form=6&db=m [Expression and significance of cyclooxygenase-2 in human pancreatic carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949405&form=6&db=m An immunohistochemical study of cyclooxygenase-2 expression in various feline neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949718&form=6&db=m The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949841&form=6&db=m Chemotherapeutic efficacy of topical celecoxib in a murine model of ultraviolet light B-induced skin cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954496&form=6&db=m Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12956275&form=6&db=m Cyclooxygenase-2 expression in uveal melanoma: novel classification of mixed-cell-type tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957358&form=6&db=m Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958148&form=6&db=m IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958151&form=6&db=m Methanandamide increases COX-2 expression and tumor growth in murine lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958170&form=6&db=m Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960143&form=6&db=m Suppression of N-methyl-N-nitrosourea/testosterone-induced rat prostate cancer growth by celecoxib: effects on cyclooxygenase-2, cell cycle regulation, and apoptosis mechanism(s). causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963227&form=6&db=m Clinicopathologic significance of cyclooxygenase-2 overexpression in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12963430&form=6&db=m Loss of endogenous TGF-beta effect induces mouse hepatoma malignancy by correlation with cyclooxygenase-2 and VEGF. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12964309&form=6&db=m Choline phospholipid metabolites of human vascular endothelial cells altered by cyclooxygenase inhibition, growth factor depletion, and paracrine factors secreted by cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12966433&form=6&db=m n-3 polyunsaturated fatty acids decrease mucosal/epidermal reactions and enhance antitumour effect of ionising radiation with inhibition of tumour angiogenesis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12969226&form=6&db=m Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970750&form=6&db=m Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12970891&form=6&db=m Role of COX-2 in carcinogenesis of colorectal cancer and its relationship with tumor biological characteristics and patients' prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12972806&form=6&db=m Effect of combined cyclooxygenase-2 and matrix metalloproteinase inhibition on human sarcoma xenografts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13679206&form=6&db=m Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13680221&form=6&db=m Expression of cyclooxygenase-2 in chondroblastoma: immunohistochemical analysis with special emphasis on local inflammatory reaction. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499140&form=6&db=m Repetitive, noninvasive imaging of cyclooxygenase-2 gene expression in living mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499627&form=6&db=m Role of prostaglandin E2 receptors in migration of murine and human breast cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499687&form=6&db=m The expression of cyclooxygenase in transitional cell carcinoma cell lines: its correlation with tumor differentiation, invasiveness and prostanoids production. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14500353&form=6&db=m Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14501166&form=6&db=m [PPARgamma-gene therapy using an adenovirus vector for inflammatory bowel disease] causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14502644&form=6&db=m Inhibition of cutaneous ultraviolet light B-mediated inflammation and tumor formation with topical celecoxib treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14503852&form=6&db=m Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14505806&form=6&db=m Effects of wogonin, a plant flavone from Scutellaria radix, on skin inflammation: in vivo regulation of inflammation-associated gene expression. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14508829&form=6&db=m The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14508834&form=6&db=m Cyclooxygenase-2 in oligodendroglial neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14515176&form=6&db=m Regulation of endothelial cell integrin function and angiogenesis by COX-2, cAMP and Protein Kinase A. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14519750&form=6&db=m Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: a rational advance? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14519938&form=6&db=m Inhibitory effects of nardostachin on nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha production in lipopolysaccharide activated macrophages. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14521608&form=6&db=m Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: correlation with suppression of cyclooxygenase-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14521714&form=6&db=m Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14526408&form=6&db=m Enhanced expression of enterocyte P-glycoprotein depresses cyclosporine bioavailability in a recipient of living donor liver transplantation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529398&form=6&db=m Cyclooxygenase-2 biology. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529406&form=6&db=m Cyclooxygenase-2 inhibition and gastric cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529784&form=6&db=m Lipid a radiosensitizes hypoxic EMT-6 tumor cells: role of the NF-kappaB signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530048&form=6&db=m Lung cancer and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14530489&form=6&db=m Synthesis and in vivo evaluation of 18F-desbromo-DuP-697 as a PET tracer for cyclooxygenase-2 expression. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14531950&form=6&db=m Nimesulide inhibits tumor growth in mice implanted hepatoma: overexpression of Bax over Bcl-2. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14531955&form=6&db=m Atherosclerotic cardiovascular disease in rheumatoid arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532840&form=6&db=m Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532968&form=6&db=m Establishment and characterization of novel xenograft models of human biliary tract carcinomas. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532971&form=6&db=m Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532998&form=6&db=m Overexpression of cyclooxygenase-2 protein and its relationship to apoptosis in cervical carcinoma treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534699&form=6&db=m Cyclooxygenase-2 expression in lymph node metastasis of cervical and vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14550281&form=6&db=m Aberrant methylation of the specific CpG island portion regulates cyclooxygenase-2 gene expression in human gastric carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552327&form=6&db=m COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552703&form=6&db=m Immune restoration in head and neck cancer patients via cyclooxygenase inhibition: an update. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555502&form=6&db=m Celecoxib modulates the expression of cyclooxygenase-2, ki67, apoptosis-related marker, and microvessel density in human cervical cancer: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555660&form=6&db=m Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555963&form=6&db=m Cell-cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14557269&form=6&db=m Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14558947&form=6&db=m [Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular endothelial growth factor (VEGF) in pancreatic carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561524&form=6&db=m Tissue microarray study for classification of breast tumors. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14563940&form=6&db=m COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566258&form=6&db=m Cyclooxygenase-2 inhibition decreases primary and metastatic tumor burden in a murine model of orthotopic lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566822&form=6&db=m The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566964&form=6&db=m Contribution of membrane-associated prostaglandin E2 synthase to bone resorption. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14568683&form=6&db=m Correlation between cyclooxygenase-2 and tumor angiogenesis in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575647&form=6&db=m Cyclooxygenases in the skin: pharmacological and toxicological implications. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14583467&form=6&db=m Inhibition of angiotensin II activity enhanced the antitumor effect of cyclooxygenase-2 inhibitors via insulin-like growth factor I receptor pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14586377&form=6&db=m The effects of pre-B-cell colony-enhancing factor on the human fetal membranes by microarray analysis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587561&form=6&db=m Selective inhibition of cyclooxygenase 2 induces p27kip1 and skp2 in oral squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587862&form=6&db=m COX-2 inhibitors for the prevention of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594546&form=6&db=m Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14594936&form=6&db=m Chemoprevention of cancer--focusing on clinical trials. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14596920&form=6&db=m Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597555&form=6&db=m COX-2-dependent stabilization of survivin in non-small cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14597668&form=6&db=m Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14599301&form=6&db=m Role of cyclooxygenase-2 inhibitors in combination with radiation therapy in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14601096&form=6&db=m Antiangiogenetic therapy with pioglitazone, rofecoxib, and metronomic trofosfamide in patients with advanced malignant vascular tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14603531&form=6&db=m Reduction of intracellular pH inhibits constitutive expression of cyclooxygenase-2 in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14605950&form=6&db=m Expression of cyclooxygenase-1 and -2 in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14607721&form=6&db=m Expression of cyclooxygenase-1 and -2 in extra-hepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14608118&form=6&db=m Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14610907&form=6&db=m The cyclooxygenase-2 pathway as a target for treatment or prevention of cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14611673&form=6&db=m A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14614028&form=6&db=m Inhibition of cyclooxygenase-2 indirectly potentiates antitumor effects of photodynamic therapy in mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14616542&form=6&db=m Cyclooxygenase-2 and gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14619604&form=6&db=m Gene activity associated with cancers treated by surgical oncologists. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14619964&form=6&db=m Arachidonic acid and colorectal carcinogenesis. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623055&form=6&db=m The effect of deletion of cyclooxygenase-2, prostaglandin receptor EP2, or EP4 in bone marrow cells on osteoclasts induced by mouse mammary cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623542&form=6&db=m Celecoxib anti-aromatase neoadjuvant (CAAN) trial for locally advanced breast cancer: preliminary report. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623548&form=6&db=m Breast cancer prevention--clinical trials strategies involving aromatase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14625126&form=6&db=m Cyclooxygenase-2 expression in the endometrium at the end of 2 years' continuous combined hormone replacement therapy. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14626203&form=6&db=m Differential expression pattern of cyclooxygenase-1 and -2 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14627349&form=6&db=m Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14629099&form=6&db=m Barrett's esophagus: chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14632205&form=6&db=m Epidermal COX-2 induction following ultraviolet irradiation: suggested mechanism for the role of COX-2 inhibition in photoprotection. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14632663&form=6&db=m Dihomo-gamma-linolenic acid inhibits tumour necrosis factor-alpha production by human leucocytes independently of cyclooxygenase activity. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633654&form=6&db=m Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633657&form=6&db=m Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633712&form=6&db=m Use of cyclooxygenase-2 inhibition to enhance the efficacy of immunotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633942&form=6&db=m Comparison of cyclooxygenase 2 expression in adenocarcinomas of the gastric cardia and distal oesophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14634277&form=6&db=m Cyclooxygenase-independent induction of p21WAF-1/cip1, apoptosis and differentiation by L-745,337, a selective PGH synthase-2 inhibitor, and salicylate in HT-29 cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14637390&form=6&db=m Anti-angiogenic therapy in breast cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14640580&form=6&db=m Methanolic extract of adlay seed suppresses COX-2 expression of human lung cancer cells via inhibition of gene transcription. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14640918&form=6&db=m Cyclooxygenase inhibition in cancer prevention and treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14642098&form=6&db=m [The clinical significance of expression of cyclooxygenase-2 gene in breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14642793&form=6&db=m Impaired gastric ulcer healing in diabetic rats: role of heat shock protein, growth factors, prostaglandins and proinflammatory cytokines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14643442&form=6&db=m Chemoprevention of mammary carcinogenesis in female rats by rofecoxib. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14645683&form=6&db=m PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14647459&form=6&db=m Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14648401&form=6&db=m Inhibitory effects of a new iridoid, patridoid II and its isomers, on nitric oxide and TNF-alpha production in cultured murine macrophages. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14648704&form=6&db=m PGE2-mediated upregulation of iNOS in murine breast cancer cells through the activation of EP4 receptors. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14649330&form=6&db=m Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and reality. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654072&form=6&db=m Inhibition of cyclooxygenase-2: a new targeted therapy for B-cell lymphoma? causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654083&form=6&db=m Increased cyclooxygenase-2 (COX-2): a potential role in the pathogenesis of lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654921&form=6&db=m Combined treatment with selective cyclooxygenase-2 inhibitor and fluorinated pyrimidines for liver metastasis of colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654930&form=6&db=m Synergistic action of piroxicam on the eicosapentaenoic acid-induced apoptosis is associated with enhanced down-regulation of anti-apoptotic Bcl-2 expression but not promoted activation of pro-apoptotic Bid protein. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14654968&form=6&db=m Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14659355&form=6&db=m Expression of cyclooxygenase-2 in fine-needle aspirates from breast carcinoma and benign breast diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14664746&form=6&db=m Nutritional and botanical modulation of the inflammatory cascade--eicosanoids, cyclooxygenases, and lipoxygenases--as an adjunct in cancer therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667176&form=6&db=m The expression of immune-regulatory genes in rainbow trout, Oncorhynchus mykiss, during a natural outbreak of proliferative kidney disease (PKD). unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14671726&form=6&db=m Cyclooxygenase-2 and prostaglandins in articular tissues. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14678698&form=6&db=m [Role of cyclooxygenase-2 in the pathogenesis of chronic liver diseases] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681319&form=6&db=m Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14684578&form=6&db=m Acute dehydrating disease caused by Vibrio cholerae serogroups O1 and O139 induce increases in innate cells and inflammatory mediators at the mucosal surface of the gut. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688410&form=6&db=m Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688483&form=6&db=m Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691908&form=6&db=m Cyclooxygenase-2 expression in stromal tumors of the gastrointestinal tract. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693736&form=6&db=m Immune profiling of plasma and cervical secretions using recycling immunoaffinity chromatography. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693742&form=6&db=m The cyclooxygenase-2 inhibitor, celecoxib, prevents the development of mammary tumors in Her-2/neu mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14697327&form=6&db=m Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14698956&form=6&db=m Inhibition of cyclooxygenase-2 with NS-398 and the prevention of radiation-induced transformation, micronuclei formation and clonogenic cell death in C3H 10T1/2 cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14699497&form=6&db=m Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14704285&form=6&db=m Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14705634&form=6&db=m Inhibitory effects of silk protein, sericin on UVB-induced acute damage and tumor promotion by reducing oxidative stress in the skin of hairless mouse. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14706335&form=6&db=m Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14712483&form=6&db=m Significance of COX-2 expression in human renal cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14713750&form=6&db=m Inflammation as a target for prostate cancer chemoprevention: pathological and laboratory rationale. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14713756&form=6&db=m Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716842&form=6&db=m Expression of COX-2 proteins in gastric mucosal lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717230&form=6&db=m Immunohistochemical expression of COX-2 in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717665&form=6&db=m Cyclooxygenase-2 expression: a potential prognostic and predictive marker for high-grade ductal carcinoma in situ of the breast. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719060&form=6&db=m COX-2 status in relation to tumor microvessel density and VEGF expression: analysis in ovarian carcinoma patients with low versus high survival rates. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719128&form=6&db=m Study of cyclooxygenase-2 in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719154&form=6&db=m Overexpression of cyclooxygenase-2 correlates with chromosomal gain at the cyclooxygenase-2 locus and decreased patient survival in advanced colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14719508&form=6&db=m Expression of beta-catenin, COX-2 and iNOS in colorectal cancer: relevance of COX-2 adn iNOS inhibitors for treatment in Malaysia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14724149&form=6&db=m Chemoprevention of gastric cancer by celecoxib in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14726667&form=6&db=m Effects of a selective cyclooxygenase-2 inhibitor on cancer cells in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729635&form=6&db=m Synergy between celecoxib and radiotherapy results from inhibition of cyclooxygenase-2-derived prostaglandin E2, a survival factor for tumor and associated vasculature. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734465&form=6&db=m Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734494&form=6&db=m Prevention strategies with aromatase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14735188&form=6&db=m COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14736730&form=6&db=m Tumor growth inhibition by indomethacin in a mouse model of human medullary thyroid cancer: implication of cyclooxygenases and 15-hydroxyprostaglandin dehydrogenase. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14739609&form=6&db=m Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14743207&form=6&db=m Phosphorylation status of c-Kit and Epo receptors, and the presence of wild-type p53 confer in vitro resistance of murine erythroleukemic cells to Celecoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14743889&form=6&db=m Role of cyclooxygenase-2 in the development and treatment of oesophageal adenocarcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744746&form=6&db=m A mechanism for cox-2 inhibitor anti-inflammatory activity in chemoprevention of epithelial cancers. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14750244&form=6&db=m COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung. A study of 117 patients from Brazil. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751245&form=6&db=m Suppression of prostaglandin E2 receptor subtype EP2 by PPARgamma ligands inhibits human lung carcinoma cell growth. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751505&form=6&db=m Potentiation of tumor response to radiation or chemoradiation by selective cyclooxygenase-2 enzyme inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751545&form=6&db=m Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression in human tracheal smooth muscle cells: involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-kappaB. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14754878&form=6&db=m COX-2 gene promoter haplotypes and prostate cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760075&form=6&db=m Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14760389&form=6&db=m Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766245&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in non-neoplastic and neoplastic vulvar epithelial lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766253&form=6&db=m Cyclooxygenase-2 expression predicts recurrence of cervical dysplasia following loop electrosurgical excision procedure. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766256&form=6&db=m Cyclooxygenase-1 and 2 in normal and malignant human ovarian epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14767568&form=6&db=m Relationship between lipoxygenase and human testicular cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14769925&form=6&db=m Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871855&form=6&db=m Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871981&form=6&db=m Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14871987&form=6&db=m Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14960510&form=6&db=m Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14962510&form=6&db=m A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14963015&form=6&db=m Cyclooxygenase-2 inhibitors suppress the growth of human hepatocellular carcinoma implants in nude mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14965324&form=6&db=m Renal COX-2, cytokines and 20-HETE: tubular and vascular mechanisms. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14965325&form=6&db=m Cancer and cyclooxygenase-2 (COX-2) inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14965326&form=6&db=m Dysregulated post-transcriptional control of COX-2 gene expression in cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14965327&form=6&db=m Cyclooxygenase-2: potential role in regulation of drug efflux and multidrug resistance phenotype. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14967078&form=6&db=m Cyclooxygenase-2 inhibitors in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14969817&form=6&db=m Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14971881&form=6&db=m Overexpression of cyclooxygenase-2 in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14972014&form=6&db=m Pro/antioxidant status in murine skin following topical exposure to cumene hydroperoxide throughout the ontogeny of skin cancer. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14973242&form=6&db=m Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14975359&form=6&db=m Proinflammatory cytokines enhance COX-1 gene expression in cultured rat glomerular mesangial cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14976201&form=6&db=m Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14977856&form=6&db=m Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator- activated receptor-gamma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981580&form=6&db=m Improvement strategies for molecular targeting: Cyclooxygenase-2 inhibitors as radiosensitizers for non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981815&form=6&db=m [Expression of cyclooxygenase in bladder transitional cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981912&form=6&db=m A selective cyclooxygenase-2 inhibitor, NS-398, inhibits cell growth by cell cycle arrest in a human malignant fibrous histiocytoma cell line. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981968&form=6&db=m Expression of cyclooxygenase-2, Fas and Fas ligand in pulmonary adenocarcinoma and atypical adenomatous hyperplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14984767&form=6&db=m Endothelial cell integrins and COX-2: mediators and therapeutic targets of tumor angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14984945&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14984962&form=6&db=m Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14985703&form=6&db=m Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14989896&form=6&db=m [Expression of cyclooxygenase-2 in esophageal squamous cell carcinogenesis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991050&form=6&db=m Human lupus T cells resist inactivation and escape death by upregulating COX-2. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991639&form=6&db=m Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991895&form=6&db=m Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14993030&form=6&db=m Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14996749&form=6&db=m Cyclooxygenase-2-dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999366&form=6&db=m Cyclooxygenase-2 inhibitors in glioma therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15000150&form=6&db=m Role of cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15001242&form=6&db=m Cyclooxygenase-2 expression correlates with diminished survival in invasive breast cancer treated with mastectomy and radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010818&form=6&db=m Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15010822&form=6&db=m Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014002&form=6&db=m Cyclooxygenase inhibition as a target for prevention of tobacco-related cancers. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014004&form=6&db=m NSAIDs for the chemoprevention of oral cancer: promise or pessimism?: Commentary re J. L. Mulshine et al., randomized, double-blind, placebo-controlled, phase IIB trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia. Clin. Cancer Res., 10: 1565-1573, 2004. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014005&form=6&db=m Randomized, double-blind, placebo-controlled phase IIb trial of the cyclooxygenase inhibitor ketorolac as an oral rinse in oropharyngeal leukoplakia. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014019&form=6&db=m Prognostic significance of cyclooxygenase-2 in oropharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014359&form=6&db=m Assessment of cyclooxygense-2 expression with 99mTc-labeled celebrex. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014363&form=6&db=m Sequence-dependent effect of a cyclooxygenase-2 inhibitor on topoisomerase I inhibitor and 5-fluorouracil-induced cytotoxicity of colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15016316&form=6&db=m Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF-kappaB/IkappaB pathway. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15016835&form=6&db=m Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15017587&form=6&db=m Cyclooxygenase-2, Bcl-2, and chromosome 1p analysis in protoplasmic astrocytomas. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15018897&form=6&db=m UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15020200&form=6&db=m Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15022726&form=6&db=m Effect of Trolox on altered vasoregulatory gene expression in hepatic ischemia/reperfusion. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15023244&form=6&db=m Prognostic impact of cyclooxygenase-2 in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15025797&form=6&db=m Cyclooxygenase-2 expression in right- and left-sided colon cancer: a rationale for optimization of cyclooxygenase-2 inhibitor therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026333&form=6&db=m Hypermethylation of CpG islands in primary and metastatic human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026550&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15027481&form=6&db=m Inflammation and cancer: an epidemiological perspective. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15027493&form=6&db=m Cyclooxygenase 2: from inflammation to carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15032641&form=6&db=m Novel non-steroidal anti-inflammatory drugs: what we have learned from animal studies. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15033900&form=6&db=m Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15034803&form=6&db=m Eicosanoid regulation of angiogenesis in tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15036657&form=6&db=m 20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15038780&form=6&db=m Phenotypic characterization of a human synovial sarcoma cell line, SW982, and its response to dexamethasone. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15045933&form=6&db=m [Barrett's esophageal adenocarcinoma] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15047306&form=6&db=m Assessment of angiogenesis: implications for ultrasound imaging. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15047734&form=6&db=m Distribution of constitutive (COX-1) and inducible (COX-2) cyclooxygenase in postviral human liver cirrhosis: a possible role for COX-2 in the pathogenesis of liver cirrhosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15049901&form=6&db=m Cyclooxygenase-2 expression and relationship to tumour progression in human renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15052544&form=6&db=m Cyclooxygenase-2: a potential target in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15055524&form=6&db=m The correlation between cyclooxygenase-2 expression and hepatocellular carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15055526&form=6&db=m NS398 inhibits the growth of Hep3B human hepatocellular carcinoma cells via caspase-independent apoptosis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15062852&form=6&db=m Expression of cyclooxygenase-1 and 2 in naturally-occurring canine cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15066236&form=6&db=m What's New in the Field of Prostate Cancer Chemoprevention? causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067356&form=6&db=m Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067366&form=6&db=m The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15068324&form=6&db=m HER-2, EGFR, COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15068837&form=6&db=m Celecoxib: a potent cyclooxygenase-2 inhibitor in cancer prevention. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15069535&form=6&db=m Inhibitory effects of etodolac, a selective COX-2 inhibitor, on the occurrence of tumors in colitis-induced tumorigenesis model in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075004&form=6&db=m Expression of cyclooxygenase-1 and -2 and clinicopathologic features of colorectal cancer in northern Thailand. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15078985&form=6&db=m Cyclooxygenase (COX)-2-dependent effects of the inhibitor SC236 when combined with ionizing radiation in mammary tumor cells derived from HER-2/neu mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15080623&form=6&db=m Constituents of Asparagus officinalis evaluated for inhibitory activity against cyclooxygenase-2. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15084845&form=6&db=m Expression of Cox-2, CD34, Bcl-2, and p53 and survival in patients with primary peritoneal serous carcinoma and primary ovarian serous carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15085079&form=6&db=m Doxycycline inhibits cell proliferation and invasive potential: combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15086604&form=6&db=m Expression of cyclooxygenase-2 in cholangiocarcinoma: correlation with clinicopathological features and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087410&form=6&db=m Serum proteomic profiles suggest celecoxib-modulated targets and response predictors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087416&form=6&db=m Correspondence re: M. V. Swamy et al., Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. Cancer Res 2003;63:5239-42. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15088099&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15090465&form=6&db=m Curcumin impairs tumor suppressor p53 function in colon cancer cells. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15093674&form=6&db=m Effect of retinoids on LPS-induced COX-2 expression and COX-2 associated PGE(2) release from mouse peritoneal macrophages and TNF-alpha release from rat peripheral blood mononuclear cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102519&form=6&db=m Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102586&form=6&db=m COX-2 inhibition in cancer therapeutics: a field of controversy or a magic bullet? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102673&form=6&db=m Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15111350&form=6&db=m Expression of Cox-2 protein in radioresistant laryngeal cancer. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15112579&form=6&db=m Nuclear factor-kappa B regulates cyclooxygenase-2 expression and cell proliferation in human colorectal carcinoma tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15114711&form=6&db=m [Report of two cases with pleural effusion and ascites that responded dramatically to the combination of thalidomide, celecoxib, irinotecan, and CDDP infused in thoracic and abdominal cavities] causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15116331&form=6&db=m Cyclooxygenase-2 expression correlates with angiogenesis and apoptosis in gastric cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15117812&form=6&db=m Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15117884&form=6&db=m Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15120641&form=6&db=m Fibronectin-induced COX-2 mediates MMP-2 expression and invasiveness of rhabdomyosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15126364&form=6&db=m Celecoxib can prevent tumor growth and distant metastasis in postoperative setting. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15130753&form=6&db=m Selective COX-2 inhibitor, NS-398, inhibits the replicative senescence of cultured dermal fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15131052&form=6&db=m Prognostic role of the ratio between cyclooxygenase-2 in tumor and stroma compartments in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15134534&form=6&db=m Leukotriene A4 hydrolase as a target for cancer prevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15136366&form=6&db=m Rofecoxib, a COX-2 inhibitor, lowers C-reactive protein and interleukin-6 levels in patients with acute coronary syndromes. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138613&form=6&db=m The effects of cyclooxygenase-2 inhibitors on urological cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138622&form=6&db=m An aqueous extract of Platycodi radix inhibits LPS-induced NF-kappaB nuclear translocation in human cultured airway epithelial cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15139997&form=6&db=m Expression of COX-2 is increased with age in papillary thyroid cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15144801&form=6&db=m Expression of cyclooxygenase-1 and -2 in canine nasal carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145695&form=6&db=m COX-2 inhibition demonstrates potent anti-proliferative effects on bladder cancer in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150098&form=6&db=m Genetic analysis of macrophage characteristics as a tool to identify tumor susceptibility genes: mapping of three macrophage-associated risk inflammatory factors, marif1, marif2, and marif3. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15150127&form=6&db=m Combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor (celecoxib) elicits antitumor immunity and long-term survival in CEA.Tg/MIN mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151619&form=6&db=m Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15153839&form=6&db=m Cyclooxygenase in the treatment of glioma: its complex role in signal transduction. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15156159&form=6&db=m Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15157676&form=6&db=m Ceramide-induced enhancement of secretory phospholipase A2 expression via generation of reactive oxygen species in tumor necrosis factor-alpha-stimulated mesangial cells. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161010&form=6&db=m Different expression of cyclooxygenase-2 in biliary epithelia of bile duct cancer with or without pancreaticobiliary maljunction. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15162003&form=6&db=m Cyclo-oxygenase 2 expression in laryngeal squamous cell carcinoma and its clinical correlates. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15163022&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in colorectal carcinoma assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15165031&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15170663&form=6&db=m Reduction of tumor progression and paraneoplastic syndrome development in murine lung adenocarcinoma by nonsteroidal antiinflammatory drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15173710&form=6&db=m Prognostic significance of vascular endothelial growth factor and cyclooxygenase 2 expression in patients receiving preoperative chemoradiation for esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15175041&form=6&db=m Treatment with 5-fluorouracil and celecoxib displays synergistic regression of ultraviolet light B-induced skin tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179620&form=6&db=m Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179621&form=6&db=m The role of COX-2 inhibition in breast cancer treatment and prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179623&form=6&db=m COX-2 inhibition and lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15180502&form=6&db=m Potent chemopreventive agents against pancreatic cancer. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15181007&form=6&db=m Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15182426&form=6&db=m Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15183459&form=6&db=m Benzo[a]pyrene diol epoxide up-regulates COX-2 expression through NF-kappaB in rat astrocytes. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15187092&form=6&db=m The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15195890&form=6&db=m Systemic treatment of hepatocellular carcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197770&form=6&db=m Suppression of cyclooxygenase-2 overexpression by 15S-hydroxyeicosatrienoic acid in androgen-dependent prostatic adenocarcinoma cells. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197778&form=6&db=m Inverse expression of dihydrodiol dehydrogenase and glutathione-S-transferase in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15199610&form=6&db=m Role of COX-2 inhibitors in cancer therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15199615&form=6&db=m COX-2 inhibitors as cancer treatment: will they be the new warfarin or trastuzumab? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15200266&form=6&db=m Expression of cyclooxygenase-2 in canine epithelial nasal tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15207385&form=6&db=m Effects of adlay on azoxymethane-induced colon carcinogenesis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15213717&form=6&db=m Antimetastatic activity of a cyclooxygenase-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217498&form=6&db=m Promoter methylation regulates cyclooxygenase expression in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15217972&form=6&db=m Cyclooxygenase as a target in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218294&form=6&db=m Cyclooxygenase-2 expression in chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222037&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222049&form=6&db=m Anti-cancer effects of COX-2 inhibitors and their correlation with angiogenesis and invasion in gastric cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15224350&form=6&db=m Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15225597&form=6&db=m Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15228443&form=6&db=m Cyclooxygenase 2 (COX2) expression is associated with poor outcome in ER-negative, but not ER-positive, breast cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15229295&form=6&db=m Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15229940&form=6&db=m Upregulation of synoviocyte COX-2 through interactions with T lymphocytes: role of interleukin 17 and tumor necrosis factor-alpha. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15230726&form=6&db=m Cyclo-oxygenase-2 expression in esophageal adenocarcinoma as a determinant of clinical outcome following esophagectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231456&form=6&db=m Colon cancer proliferating desulfosinigrin in wasabi (Wasabia japonica). ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15231670&form=6&db=m Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15234907&form=6&db=m Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239334&form=6&db=m [Cyclooxygenase 2 inhibitors and cancer chemoprevention] diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239336&form=6&db=m [Cyclooxygenase 2 inhibitors and colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239339&form=6&db=m [Cyclooxygenase 2 inhibitors and urologic and gynaecologic cancers] diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15239609&form=6&db=m Effects of anti-inflammatory cytokine agent (FR167653) and serine protease inhibitor on warm ischemia-reperfusion injury of the liver graft. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240520&form=6&db=m A cox-2 promoter-based replication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242680&form=6&db=m Nitric-oxide-donating NSAIDs as agents for cancer prevention. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15246187&form=6&db=m Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15248379&form=6&db=m Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15252927&form=6&db=m COX-2 inhibition in upper aerodigestive tract tumors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254689&form=6&db=m DFU, a selective COX-2 inhibitor, suppresses MCF-7 xenograft tumor growth in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15255176&form=6&db=m Colon cancer: genomics and apoptotic events. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15256475&form=6&db=m Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15259059&form=6&db=m Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15261433&form=6&db=m Clinico-pathological and biological prognostic factors in pleural malignant mesothelioma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15266025&form=6&db=m Interleukin-1beta-induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP-protein kinase A signaling. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15266333&form=6&db=m Clinical implication of expression of cyclooxygenase-2 and peroxisome proliferator activated-receptor gamma in epithelial ovarian tumours. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15269139&form=6&db=m Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15270659&form=6&db=m COX-2 and its inhibition as a molecular target in the prevention and treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272284&form=6&db=m COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15274299&form=6&db=m PHGPx overexpression induces an increase in COX-2 activity in colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15274307&form=6&db=m Cyclooxygenase-2 expression in human gastric tubular adenomas and carcinomas; correlation with intratumoral microvessel density and apoptotic index. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15280016&form=6&db=m Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15285012&form=6&db=m COX-2 expression and tumor angiogenesis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15285921&form=6&db=m Cyclooxygenase-2 and gastrointestinal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15287038&form=6&db=m Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15287094&form=6&db=m Chronic inflammation in benign prostate hyperplasia is associated with focal upregulation of cyclooxygenase-2, Bcl-2, and cell proliferation in the glandular epithelium. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289320&form=6&db=m Inhibition of activator protein 1 activation, vascular endothelial growth factor, and cyclooxygenase-2 expression by 15-deoxy-Delta12,14-prostaglandin J2 in colon carcinoma cells: evidence for a redox-sensitive peroxisome proliferator-activated receptor-gamma-independent mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289856&form=6&db=m Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289892&form=6&db=m A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15294912&form=6&db=m Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15295626&form=6&db=m Regulatory pathways in photodynamic therapy induced apoptosis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15296859&form=6&db=m Multifaceted roles of cyclooxygenase-2 in lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15297183&form=6&db=m Hypoxia up-regulates the effects of prostaglandin E2 on tumor angiogenesis in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298620&form=6&db=m Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15299086&form=6&db=m Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer? causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15299197&form=6&db=m Expression of cyclooxygenase-2 and thromboxane synthase in non-neoplastic and neoplastic thyroid lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15300574&form=6&db=m Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15306168&form=6&db=m Effect of ascorbic acid on hepatic vasoregulatory gene expression during polymicrobial sepsis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15309515&form=6&db=m Prevention of colorectal cancer through the use of COX-2 selective inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15311968&form=6&db=m An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313405&form=6&db=m Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313472&form=6&db=m Effects of TGF-beta, TNF-alpha, IL-beta and IL-6 alone or in combination, and tyrosine kinase inhibitor on cyclooxygenase expression, prostaglandin E2 production and bone resorption in mouse calvarial bone cells. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313895&form=6&db=m Cyclooxygenase-1 deletion enhances apoptosis but does not protect against ultraviolet light-induced tumors. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15317910&form=6&db=m Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319299&form=6&db=m Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15325613&form=6&db=m NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15326546&form=6&db=m Natural inhibitors of carcinogenesis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15327557&form=6&db=m Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15328200&form=6&db=m Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15328521&form=6&db=m RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15330186&form=6&db=m Survival in small cell lung cancer is independent of tumor expression of VEGF and COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332534&form=6&db=m [COX and study of cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15340847&form=6&db=m Cyclooxygenase-2 and its role in colorectal cancer development. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15342458&form=6&db=m Cyclooxygenase-2 and p53 expressions in endometrial cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15343602&form=6&db=m Color Doppler velocimetry and three-dimensional color power angiography of cervical carcinoma. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15347673&form=6&db=m Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15350631&form=6&db=m Rapid method for identification of chemopreventive compounds using multiplex RT-PCR for cyclooxygenase mRNA expression. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15351711&form=6&db=m Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by butein in RAW 264.7 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15353307&form=6&db=m Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15354416&form=6&db=m A selective cyclooxygenase-2 inhibitor, NS398, inhibits cell growth and induces cell cycle arrest in the G2/M phase in human esophageal squamous cell carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15355919&form=6&db=m Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15357006&form=6&db=m Expression of hepatic vascular stress genes following ischemia/reperfusion and subsequent endotoxemia. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358633&form=6&db=m n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358636&form=6&db=m NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15359292&form=6&db=m Herpes simplex virus thymidine kinase gene transduction enhances tumor growth rate and cyclooxygenase-2 expression in murine colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15359639&form=6&db=m Cyclooxygenase-2 (Cox-2) expression in lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15361286&form=6&db=m Relationship between COX-2 expression and clinicopathological features of colorectal cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15362039&form=6&db=m Ursodeoxycholate/Sulindac combination treatment effectively prevents intestinal adenomas in a mouse model of polyposis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15371874&form=6&db=m Enhanced sensitivity of bladder cancer cells to cisplatin mediated cytotoxicity and apoptosis in vitro and in vivo by the selective cyclooxygenase-2 inhibitor JTE-522. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15371919&form=6&db=m Influence of gastritis on cyclooxygenase-2 expression before and after eradication of Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15372235&form=6&db=m Expression of proteins related to prostaglandin E2 biosynthesis is increased in human gastric cancer and during gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374627&form=6&db=m Cyclooxygenases in cancer: progress and perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374938&form=6&db=m Cyclooxygenase 2-dependent expression of survivin is critical for apoptosis resistance in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374967&form=6&db=m Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15375582&form=6&db=m Cyclooxygenase-2 in human malignant fibrous histiocytoma: correlations with intratumoral microvessel density, expression of vascular endothelial growth factor and thymidine phosphorylase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15377291&form=6&db=m Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15379214&form=6&db=m Induction of microsomal prostaglandin E synthase-1 in human gingival fibroblasts. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15380175&form=6&db=m Expression of cyclooxygenase-2, Bcl-2 and Ki-67 in pleomorphic adenoma with special reference to tumor proliferation and apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383564&form=6&db=m Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383758&form=6&db=m Acid suppression and chemoprevention in Barrett's oesophagus. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15383996&form=6&db=m [Prostate carcinoma: higher COX-2 contents in advanced tumors] causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15384741&form=6&db=m COX-2 inhibition and cancer: experimental findings and clinical correlates. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15385109&form=6&db=m Cyclooxygenase-2 expression in borderline ovarian tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386340&form=6&db=m Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resistance protein, prostaglandin E synthetase, and glutathione-S-transferase-alpha (GST)-alpha, GST-mu, and GST-pi. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386343&form=6&db=m JTE-522, a selective COX-2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: a vascular cast model study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15386410&form=6&db=m Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15450303&form=6&db=m Cyclooxygenase-2 parallels invasive depth and increased MVD in transitional cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15454489&form=6&db=m A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2-independent mechanism. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15455372&form=6&db=m Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15455390&form=6&db=m Increased endothelial uptake of paclitaxel as a potential mechanism for its antiangiogenic effects: potentiation by Cox-2 inhibition. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456640&form=6&db=m Effect of red clover isoflavones on cox-2 activity in murine and human monocyte/macrophage cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15457128&form=6&db=m Studies of synergistic and antagonistic combinations of conventional cytotoxic agents with the multiple eicosanoid pathway modulator LY 293111. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15458769&form=6&db=m The potential role of cyclooxygenase-2 inhibitors in the treatment of experimentally-induced mammary tumour: does celecoxib enhance the anti-tumour activity of doxorubicin? causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15459875&form=6&db=m [Cyclooxygenase-2-expression in bladder cancer: tumor-biological and clinical implications] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15460407&form=6&db=m [Expression and clinical significance of cyclooxygenase-2 in medulloblastoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15461861&form=6&db=m Cyclooxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15464057&form=6&db=m Cyclooxygenase inhibition in human monocytes increases endotoxin-induced TNF alpha without affecting cyclooxygenase-2 expression. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466184&form=6&db=m Oncogenic action of secreted phospholipase A2 in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15469386&form=6&db=m Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15469954&form=6&db=m Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471895&form=6&db=m Targeted over-expression of mPGES-1 and elevated PGE2 production is not sufficient for lung tumorigenesis in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15472909&form=6&db=m Selective inhibition of cyclooxygenase (COX)-2 inhibits endothelial cell proliferation by induction of cell cycle arrest. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15473662&form=6&db=m Stylopine from Chelidonium majus inhibits LPS-induced inflammatory mediators in RAW 264.7 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15473933&form=6&db=m [Effect of cyclooxygenase-2,and matrix metalloproteinase-2 expression on prognosis of lung cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475935&form=6&db=m Role of COX-2, thromboxane A2 synthase, and prostaglandin I2 synthase in papillary thyroid carcinoma growth. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475936&form=6&db=m Cytoplasmic phospholipase A2 alpha overexpression in stromal cells is correlated with angiogenesis in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476850&form=6&db=m Targeting signal transduction pathways by chemopreventive agents. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476855&form=6&db=m Nitric oxide signaling in colon cancer chemoprevention. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15477758&form=6&db=m Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15480979&form=6&db=m Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15482328&form=6&db=m Increased expression of cyclooxygenase (COX)-2 in DMBA-induced hamster cheek pouch carcinogenesis and chemopreventive effect of a selective COX-2 inhibitor celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15483103&form=6&db=m Distinct regulation of cyclooxygenase-2 by interleukin-1beta in normal and endometriotic stromal cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15484698&form=6&db=m Cyclooxygenase-2 in oligodendroglioma: possible prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15485309&form=6&db=m Celecoxib: a novel treatment for lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15488631&form=6&db=m Role of chemopreventive agents in cancer therapy. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15489888&form=6&db=m Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491425&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492235&form=6&db=m Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492268&form=6&db=m Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492414&form=6&db=m Negative feedback regulation of phosphatidylinositol 3-kinase/Akt pathway by over-expressed cyclooxygenase-2 in human epidermal cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494133&form=6&db=m Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498296&form=6&db=m [The significance of the expression of cyclooxygenase-2 in bladder transitional cell carcinoma tissues] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498788&form=6&db=m Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15499599&form=6&db=m Elevated expression of cyclooxygenase-2 in breast cancer and ductal carcinoma in situ has no correlation with established prognostic markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501074&form=6&db=m COX-2 inhibition as a tool to treat and prevent colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501253&form=6&db=m Constituents of the stems of Macrococculus pomiferus and their inhibitory activities against cyclooxygenases-1 and -2. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501972&form=6&db=m Concomitant overexpression of cyclooxygenase-2 in HER-2-positive on Smad4-reduced human gastric carcinomas is associated with a poor patient outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501994&form=6&db=m Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute myeloid leukemic HL-60 cells. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15504246&form=6&db=m Cloning of Mongolian gerbil cDNAs encoding inflammatory proteins, and their expression in glandular stomach during H. pylori infection. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15509713&form=6&db=m Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15521009&form=6&db=m Up-regulation of the enzymes involved in prostacyclin synthesis via Ras induces vascular endothelial growth factor. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15523901&form=6&db=m Sequential expression of inducible nitric oxide synthase and cyclooxygenase-2 during DMBA-induced hamster buccal pouch carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15525653&form=6&db=m Integrin-mediated adhesion and soluble ligand binding stabilize COX-2 protein levels in endothelial cells by inducing expression and preventing degradation. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15531779&form=6&db=m Activation of inflammatory mediators and potential role of ah-receptor ligands in foam cell formation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15532792&form=6&db=m Overexpression of cyclooxygenase-2 and tumor angiogenesis in human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15537300&form=6&db=m Tumor cell proliferation and cyclooxygenase enzyme inhibitory compounds in Amaranthus tricolor. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15538221&form=6&db=m Impact of cyclooxygenase-2 gene expression on tumor invasiveness in a human renal cell carcinoma cell line. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539913&form=6&db=m Concomitant radiochemotherapy plus surgery in locally advanced cervical cancer: update of clinical outcome and cyclooxygenase-2 as predictor of treatment susceptibility. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15542977&form=6&db=m Meningioma: an update. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15547942&form=6&db=m Arsenic trioxide represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15550400&form=6&db=m Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15555568&form=6&db=m Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15561779&form=6&db=m Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15562904&form=6&db=m Elevated expression of cyclooxygenase-2 in adenocarcinoma of the parotid gland: insights into malignant transformation of pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15564149&form=6&db=m Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15566290&form=6&db=m New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569051&form=6&db=m Comparative analysis of COX-2, vascular endothelial growth factor and microvessel density in human renal cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15569052&form=6&db=m High microvascular density is correlated with high VEGF, iNOS and COX-2 expression in penetrating growth-type early gastric carcinomas. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15570054&form=6&db=m Vitamin E and breast cancer. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15572759&form=6&db=m Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574495&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15577196&form=6&db=m Molecular Mechanisms Behind the Chemopreventive Effects of Anthocyanidins. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15581957&form=6&db=m Expression of cyclooxygenase-2 in adenocarcinomas of the uterine cervix and its relation to angiogenesis and tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15582199&form=6&db=m Bile acid induced gene expression in LT97 colonic adenoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585388&form=6&db=m Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585629&form=6&db=m Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585631&form=6&db=m Increased angiogenesis and lymphangiogenesis in inflammatory versus noninflammatory breast cancer by real-time reverse transcriptase-PCR gene expression quantification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585639&form=6&db=m Inhibition of cyclooxygenase (COX)-2 expression by Tet-inducible COX-2 antisense cDNA in hormone-refractory prostate cancer significantly slows tumor growth and improves efficacy of chemotherapeutic drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15587390&form=6&db=m Expression and significance of cyclooxygenase 2 gene in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15589400&form=6&db=m Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15589595&form=6&db=m COX-2, c-KIT and HER-2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15591708&form=6&db=m Effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on cardiovascular alterations in endotoxemia. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15592025&form=6&db=m Expression of cyclooxygenase-2 and EP4 receptor in transitional cell carcinoma of the upper urinary tract. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596182&form=6&db=m Significance of COX-2 expression in human renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596291&form=6&db=m Polymorphism in the nuclear factor kappa-B binding promoter region of cyclooxygenase-2 is associated with an increased risk of bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15598938&form=6&db=m Clinical implications of expression of cyclooxygenase-2 related to angiogenesis in uterine endometrial cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15601550&form=6&db=m [Inhibitory effects of celecoxib combined with octreotide on growth of multidrug resistant human gastric cancer cell line SGC7901/ADR.] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15603272&form=6&db=m [Is there a future for COX-2 inhibitors?] causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604060&form=6&db=m [Effect of anti-HPV16 E6-ribozyme on cell proliferation and invasiveness of cervical carcinoma cell line CaSKi.] causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604909&form=6&db=m Advances that are changing the diagnosis and treatment of malignant bone tumors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15607554&form=6&db=m Lower expression of cyclooxygenase-2: is it associated with the development of borderline ovarian tumors? causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15608668&form=6&db=m Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15609300&form=6&db=m Role of cyclooxygenase-2 in immunomodulation and prognosis of endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15619216&form=6&db=m COX-2 expression correlates with microvessel density in non-melanoma skin cancer from renal transplant recipients and immunocompetent individuals. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15621371&form=6&db=m Tumor necrosis factor alpha and interleukin-1beta stimulate the expression of cyclooxygenase II but do not alter prostaglandin E2 receptor mRNA levels in cultured dorsal root ganglia cells. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15621834&form=6&db=m Selective cyclooxygenase 2 inhibitor NS-398 induces apoptosis in myeloma cells via a Bcl-2 independent pathway. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622005&form=6&db=m Treatment of lung cancer using clinically relevant oral doses of the cyclooxygenase-2 inhibitor rofecoxib: potential value as adjuvant therapy after surgery. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622477&form=6&db=m Correlation between cyclooxygenase-2, proliferative activity, and mucin phenotype in human advanced gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622493&form=6&db=m COX-2 and advanced digestive cancer phenotypes. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622585&form=6&db=m Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623590&form=6&db=m Down-regulation of intratumoral aromatase messenger RNA levels by docetaxel in human breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623626&form=6&db=m Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15623639&form=6&db=m Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15626918&form=6&db=m Cyclooxygenase 2 expression in serous tumors of the ovary. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15627842&form=6&db=m Evaluation of expression of apoptosis-related proteins and their correlation with HPV, telomerase activity, and apoptotic index in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15628770&form=6&db=m [A case report of disseminated malignant mesothelioma of peritoneum responding remarkably to thalidomide, celecoxib, vinorelbine and CDDP] causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632379&form=6&db=m Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15634545&form=6&db=m [The role of cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of gastric cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637091&form=6&db=m Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637389&form=6&db=m Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15638270&form=6&db=m Cyclooxygenase-2 expression in canine appendicular osteosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15642051&form=6&db=m Triclosan reduces microsomal prostaglandin E synthase-1 expression in human gingival fibroblasts. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645119&form=6&db=m COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645120&form=6&db=m Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15652231&form=6&db=m Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659778&form=6&db=m The cyclooxygenase inhibitor flurbiprofen reduces radiation-induced angiogenic growth factor secretion of squamous cell carcinoma cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659835&form=6&db=m Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659838&form=6&db=m Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor kappaB. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15660656&form=6&db=m Cyclooxygenase-2 expression in primary Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15661257&form=6&db=m Is antibody therapy of tumor compromised by infusion-related reactions? A case for inhibiting the activity of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15664302&form=6&db=m Pretreatment tumor prostaglandin E2 concentration and cyclooxygenase-2 expression are not associated with the response of canine naturally occurring invasive urinary bladder cancer to cyclooxygenase inhibitor therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15664395&form=6&db=m Diversity and similarity in signaling events leading to rapid Cox-2 induction by tumor necrosis factor-alpha and phorbol ester in human endothelial cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15667901&form=6&db=m Celecoxib inhibits ureteral contractility and prostanoid release. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15671526&form=6&db=m Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15679256&form=6&db=m [Targeted drugs in radiation therapy] causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681840&form=6&db=m Cystic duct dilatations and proliferative epithelial lesions in mouse mammary glands upon keratin 5 promoter-driven overexpression of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15682318&form=6&db=m Expression and clinical significance of vascular endothelial growth factor, cyclooxygenase-2, and Bcl-2 in borderline ovarian tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683997&form=6&db=m [Effects of combined use of curcumin and catechin on cyclooxygenase-2 mRNA expression in dimethylhydrazine-induced rat colon carcinogenesis] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15684036&form=6&db=m Essential roles of Toll-like receptor-4 signaling in arthritis induced by type II collagen antibody and LPS. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685827&form=6&db=m Celecoxib and radiation therapy in non-small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15688368&form=6&db=m Cyclooxygenase-2 inhibitor celecoxib augments chemotherapeutic drug-induced apoptosis by enhancing activation of caspase-3 and -9 in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15688382&form=6&db=m Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15693092&form=6&db=m Fibroblast-like synovial cells derived from synovial fluid. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15694043&form=6&db=m [Expressions of cyclooxygenase-2 and cholecystokinin-B receptor mRNA in human colorectal cancer and their significances] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695234&form=6&db=m Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethylbenz[a]anthracene (DMBA) coated suture. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695237&form=6&db=m Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695412&form=6&db=m Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15695470&form=6&db=m Inflammation, COX-2 inhibitors, and cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15700850&form=6&db=m Cyclooxygenase-2 expression in uterine leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15701502&form=6&db=m Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15703831&form=6&db=m Significant anti-proliferation of human endometrial cancer cells by combined treatment with a selective COX-2 inhibitor NS398 and specific MEK inhibitor U0126. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15704107&form=6&db=m Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15704289&form=6&db=m COX-2 inhibitors: cancer prevention or cardiovascular risk? therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15705899&form=6&db=m Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15709198&form=6&db=m Antitumor activity of ZD6474, a vascular endothelial growth factor-2 and epidermal growth factor receptor small molecule tyrosine kinase inhibitor, in combination with SC-236, a cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15709205&form=6&db=m A fiber-modified, secretory leukoprotease inhibitor promoter-based conditionally replicating adenovirus for treatment of ovarian cancer. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15709209&form=6&db=m Cyclooxygenase inhibitor ketorolac or mast cell stabilizers: immunologic challenges in cancer therapy. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710360&form=6&db=m Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710986&form=6&db=m Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15711411&form=6&db=m COX-2: a protein with an active role in gynecological cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15713675&form=6&db=m Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15716238&form=6&db=m Cyclooxygenase 2, p53, beta-catenin, and APC protein expression in gastric adenomatous polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719215&form=6&db=m The anti-inflammatory prostaglandin 15d-PGJ2 decreases oxidative/nitrosative mediators in brain after acute stress in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719392&form=6&db=m Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15720414&form=6&db=m Association between cyclooxygenase-2-expressing macrophages, ulceration and microvessel density in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723653&form=6&db=m Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723947&form=6&db=m Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with epidermal growth factor receptor expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15726508&form=6&db=m Cyclooxygenase-2 inhibition in colorectal cancer: boom or bust? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15731164&form=6&db=m Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by raloxifene, an antiestrogen with anti-androgen action, but not nimesulide, a selective cyclooxygenase-2 inhibitor. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15731178&form=6&db=m Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15731292&form=6&db=m Synovial tissue inflammation in early and late osteoarthritis. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15734421&form=6&db=m Surgically induced accelerated local and distant tumor growth is significantly attenuated by selective COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15734963&form=6&db=m Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15735712&form=6&db=m Distinct transduction mechanisms of cyclooxygenase 2 gene activation in tumour cells after photodynamic therapy. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15735738&form=6&db=m [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15736413&form=6&db=m Effect of cyclooxygenase-2 antisense oligodeoxyribonucleotides in A-549 lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15740020&form=6&db=m Tumor cell proliferation and cyclooxygenase inhibitory constituents in horseradish (Armoracia rusticana) and Wasabi (Wasabia japonica). ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15742801&form=6&db=m Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventives. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743541&form=6&db=m JTE-522, a selective COX-2 inhibitor, inhibits growth of pulmonary metastases of colorectal cancer in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15743693&form=6&db=m Cyclo-oxygenase-1 and -2 expression in human oral mucosa, dysplasias and squamous cell carcinomas and their pathological significance. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15744816&form=6&db=m Cyclooxygenase-2 and p53 expression as prognostic indicators in conventional renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15746067&form=6&db=m Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15746677&form=6&db=m Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15750198&form=6&db=m Expression of cyclooxygenase-2 and inducible nitric oxide synthase correlates with tumor angiogenesis in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15751079&form=6&db=m Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753376&form=6&db=m p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753378&form=6&db=m Transitional cell hyperplasia and carcinomas in urinary bladders of transgenic mice with keratin 5 promoter-driven cyclooxygenase-2 overexpression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754118&form=6&db=m Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754389&form=6&db=m Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754411&form=6&db=m Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15755875&form=6&db=m Inhibition of p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase decreases UVB-induced activator protein-1 and cyclooxygenase-2 in a SKH-1 hairless mouse model. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756426&form=6&db=m Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756444&form=6&db=m Predictive value of COX-2 for the effect of chemoradiotherapy on esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15757635&form=6&db=m Acute gastric changes after intracerebral hemorrhage in rats. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15763541&form=6&db=m Dual effects of acetylsalicylic acid on mast cell degranulation, expression of cyclooxygenase-2 and release of pro-inflammatory cytokines. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15767780&form=6&db=m COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15772428&form=6&db=m Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15772955&form=6&db=m Prediction of poor survival by cyclooxygenase-2 in patients with T4 nasopharyngeal cancer treated by radiation therapy: clinical and in vitro studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15781626&form=6&db=m Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15781636&form=6&db=m Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15784648&form=6&db=m Cyclooxygenase-2 inhibitor SC-236 [4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide] suppresses nuclear factor-kappaB activation and phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and c-Jun N-terminal kinase in human mast cell line cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15788676&form=6&db=m Cytoplasmic phospholipase A2 levels correlate with apoptosis in human colon tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15789435&form=6&db=m Thrombin-activated microglia contribute to death of dopaminergic neurons in rat mesencephalic cultures: dual roles of mitogen-activated protein kinase signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15790444&form=6&db=m The expression of cyclooxygenase-2, VEGF and PGs in CIN and cervical carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15800927&form=6&db=m E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15800939&form=6&db=m Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15800977&form=6&db=m Tumor cyclooxygenase-2 levels correlate with tumor invasiveness in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15805430&form=6&db=m Cancer prevention: a new era beyond cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809733&form=6&db=m COX-2 overexpression increases motility and invasion of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809736&form=6&db=m Expression of cyclooxygenase-2 in uterine endometrial cancer and anti-tumor effects of a selective COX-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816542&form=6&db=m Growth inhibitory effect of celecoxib and rofecoxib on human colorectal carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816645&form=6&db=m Differential cyclooxygenase-2 enzyme expression in radiosensitive versus radioresistant glioblastoma multiforme cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817469&form=6&db=m Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817909&form=6&db=m High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15821352&form=6&db=m Increased PGE2 levels in nonmalignant mucosa adjacent to squamous cell carcinoma of the head and neck. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823108&form=6&db=m Increased cyclooxygenase-2 (COX-2) and P-glycoprotein-170 (MDR1) expression is associated with chemotherapy resistance and poor prognosis. Analysis in ovarian carcinoma patients with low and high survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823708&form=6&db=m Selenium supplementation may increase the efficacy of cetuximab in metastatic colorectal cancer patients. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15825079&form=6&db=m Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15825163&form=6&db=m COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15829319&form=6&db=m Adenovirus-uteroglobin suppresses COX-2 expression via inhibition of NF-kappaB activity in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15833882&form=6&db=m The retinoid X receptor-selective retinoid, LGD1069, down-regulates cyclooxygenase-2 expression in human breast cells through transcription factor crosstalk: implications for molecular-based chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15837998&form=6&db=m COX-2: a molecular target for colorectal cancer prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15838264&form=6&db=m Endothelin-1 Stimulates Cyclooxygenase-2 Expression in Ovarian Cancer Cells Through Multiple Signaling Pathways: Evidence for Involvement of Transactivation of the Epidermal Growth Factor Receptor. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15840872&form=6&db=m Researchers plan to continue to study COX-2 inhibitors in cancer treatment and prevention. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15841716&form=6&db=m Rofecoxib does not inhibit aberrant crypt foci formation but inhibits later steps in the development of experimental colorectal cancer: rofecoxib in experimental colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15842638&form=6&db=m COX-2 expression in DCIS: correlation with VEGF, HER-2/neu, prognostic molecular markers and clinicopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15844661&form=6&db=m Cyclooxygenase-2 induction and prostaglandin E2 accumulation in squamous cell carcinoma as a consequence of epidermal growth factor receptor activation by imatinib mesylate. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845650&form=6&db=m Penta-O-galloyl-beta-D-glucose suppresses tumor growth via inhibition of angiogenesis and stimulation of apoptosis: roles of cyclooxygenase-2 and mitogen-activated protein kinase pathways. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15846111&form=6&db=m A novel anti-pancreatic cancer agent, LY293111. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15846114&form=6&db=m Rapid up-regulation of cyclooxygenase-2 by 5-fluorouracil in human solid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15846217&form=6&db=m Correlation of cyclooxygenase-2 (COX-2) and aromatase expression in human endometrial cancer: tissue microarray analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15850674&form=6&db=m New insights into COX-2 biology and inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15851492&form=6&db=m COX-2 inhibitors still eyed for cancer prevention. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15855163&form=6&db=m Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15856454&form=6&db=m Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15858127&form=6&db=m Cyclooxygenase 2 expression in nasopharyngeal carcinoma: immunohistochemical findings and potential implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863127&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863148&form=6&db=m Estrogen and progesterone receptors and cyclooxygenase-2 expression in endometrial cancer, endometrial hyperplasia, and normal endometrium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863442&form=6&db=m The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15864162&form=6&db=m Analgesic usage for low back pain: impact on health care costs and service use. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15864753&form=6&db=m Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867220&form=6&db=m Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867233&form=6&db=m A phase I clinical trial of thoracic radiotherapy and concurrent celecoxib for patients with unfavorable performance status inoperable/unresectable non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867236&form=6&db=m Intratumoral COX-2 gene expression is a predictive factor for colorectal cancer response to fluoropyrimidine-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867369&form=6&db=m Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867384&form=6&db=m Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868166&form=6&db=m Combination therapy using the cyclooxygenase-2 inhibitor Parecoxib and radioimmunotherapy in nude mice with small peritoneal metastases of colonic origin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15869467&form=6&db=m Oxygenation by COX-2 (cyclo-oxygenase-2) of 3-HETE (3-hydroxyeicosatetraenoic acid), a fungal mimetic of arachidonic acid, produces a cascade of novel bioactive 3-hydroxyeicosanoids. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15869721&form=6&db=m What's new in the field of prostate cancer chemoprevention? causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15869882&form=6&db=m Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870511&form=6&db=m Prognostic factors in papillary thyroid cancer: an evaluation of 601 consecutive patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870865&form=6&db=m Cox-2 and Her2/neu co-expression in invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15872381&form=6&db=m Assessment of cyclooxygenase-2 expression in canine hemangiosarcoma, histiocytic sarcoma, and mast cell tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15875784&form=6&db=m Novel insights into the mechanism of action of intravesical immunomodulators. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878334&form=6&db=m Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878911&form=6&db=m Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878914&form=6&db=m The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15879365&form=6&db=m Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15880952&form=6&db=m Cyclooxygenase-2 regulates the degree of apoptosis by modulating bcl-2 protein in pleomorphic adenoma and mucoepidermoid carcinoma of the parotid gland. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15887126&form=6&db=m The role of prostaglandins and other eicosanoids in the gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15891886&form=6&db=m Cyclooxygenase inhibitors modulate NK activities that control metastatic disease. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15896711&form=6&db=m Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15897577&form=6&db=m Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899630&form=6&db=m [Cyclooxygenase 2 inhibitors and cancer chemoprevention] diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899632&form=6&db=m [Cyclooxygenase 2 inhibitors and colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899635&form=6&db=m [Cyclooxygenase 2 inhibitors and urologic and gynaecologic cancers] diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899788&form=6&db=m CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15899904&form=6&db=m Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15907789&form=6&db=m Resistance of prostate cancer cell lines to COX-2 inhibitor treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15911099&form=6&db=m Anti-proliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15913419&form=6&db=m Immunohistochemical expression of cyclooxygenase 2 in follicular carcinomas of the thyroid. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15921850&form=6&db=m Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15923435&form=6&db=m Concurrent EGFr and Cox-2 expression in colorectal cancer: proliferation impact and tumour spreading. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930344&form=6&db=m Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930356&form=6&db=m Chemotherapy induces the expression of cyclooxygenase-2 in non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15936552&form=6&db=m Coexpression of cyclooxygenase-2 and thymidine phosphorylase as a prognostic indicator in patients with FIGO stage IIB squamous cell carcinoma of uterine cervix treated with radiotherapy and concurrent chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15936596&form=6&db=m Sensitization of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and nordihydroguaiaretic acid. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15942563&form=6&db=m Evaluation of cyclooxygenase-2 inhibition in an orthotopic murine model of lung cancer for dose-dependent effect. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944770&form=6&db=m 5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947945&form=6&db=m Cyclooxygenase-2 in normal, hyperplastic and neoplastic follicular cells of the human thyroid gland. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15948119&form=6&db=m Overexpression of laminin-5 gamma2 chain and its prognostic significance in urothelial carcinoma of urinary bladder: association with expression of cyclooxygenase 2, epidermal growth factor receptor [corrected] and human epidermal growth factor receptor [corrected] 2. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15949789&form=6&db=m Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15950219&form=6&db=m Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15951536&form=6&db=m Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15958566&form=6&db=m Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15958620&form=6&db=m Down-regulated xanthine oxidoreductase is a feature of aggressive breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963122&form=6&db=m The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15964184&form=6&db=m Cyclooxygenase-2 expression predicts survival in malignant pleural mesothelioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15965085&form=6&db=m Inhibitory Effects of a Rice Hull Constituent on Tumor Necrosis Factor {alpha}, Prostaglandin E2, and Cyclooxygenase-2 Production in Lipopolysaccharide-Activated Mouse Macrophages. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15967161&form=6&db=m Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15967164&form=6&db=m COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15968728&form=6&db=m Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15970376&form=6&db=m Significance of cyclooxygenase 2 and MDR1/P-glycoprotein coexpression in ovarian cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15975002&form=6&db=m Novel agents that potentially inhibit irinotecan-induced diarrhea. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15975667&form=6&db=m Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15975708&form=6&db=m NSAIDs in neuroblastoma therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15978332&form=6&db=m Prognostic role of cyclooxygenase-2 expression in esophageal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15979129&form=6&db=m Expression of cyclooxygenase-2 (COX-2), receptors for estrogen (ER), and progesterone (PR), p53, ki67, and neu protein in endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15980665&form=6&db=m Cyclooxygenase-2 expression associated with severity of PanIN lesions: a possible link between chronic pancreatitis and pancreatic cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15982930&form=6&db=m Thalidomide inhibits growth of tumors through COX-2 degradation independent of antiangiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987447&form=6&db=m Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987517&form=6&db=m Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15987631&form=6&db=m MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15992053&form=6&db=m The role of COX-2 in intestinal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15993407&form=6&db=m Cyclooxygenase-2 in cancer cells and macrophages induces colon cancer cell growth by cigarette smoke extract. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15993594&form=6&db=m In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15995627&form=6&db=m PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15999272&form=6&db=m A phase I trial of celecoxib in combination with docetaxel and irinotecan in patients with advanced cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000571&form=6&db=m Cyclooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000874&form=6&db=m COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000951&form=6&db=m Chemosensitization of pancreatic carcinoma cells to enhance T cell-mediated cytotoxicity induced by tumor lysate-pulsed dendritic cells. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16001166&form=6&db=m Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16002278&form=6&db=m Cyclooxygenase-2: how good is it as a target for cancer chemoprevention? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16002678&form=6&db=m Cyclooxygenase 2 inhibition promotes IFN-gamma-dependent enhancement of antitumor responses. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16003752&form=6&db=m MF tricyclic and sulindac retard tumor formation in an animal model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16004971&form=6&db=m Combination of cyclooxygenase-2 inhibitors and oxaliplatin increases the growth inhibition and death in human colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16006146&form=6&db=m The expression of immune-regulatory genes in rainbow trout, Oncorhynchus mykiss, during amoebic gill disease (AGD). diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16006977&form=6&db=m Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16007171&form=6&db=m Nitric oxide upregulates the cyclooxygenase-2 expression through the cAMP-response element in its promoter in several cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16010419&form=6&db=m High-throughput tissue microarray analysis of COX2 expression in urinary bladder cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16011415&form=6&db=m Effect of rofecoxib on colon chemical carcinogenesis at colonic anastomotic area in the rat. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16014119&form=6&db=m Expression of HER-2/neu, epidermal growth factor receptor, vascular endothelial growth factor, cyclooxygenase-2, estrogen receptor, and progesterone receptor in small cell and large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathologic and prognostic study. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16018788&form=6&db=m Non-steroidal anti-inflammatory drugs for the prevention and treatment of cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16024629&form=6&db=m Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16027288&form=6&db=m A replication-selective adenoviral vector for head and neck cancers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16028376&form=6&db=m [COX-2 expression and ovarian cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16030101&form=6&db=m Loss of FHIT expression in breast cancer is correlated with poor prognostic markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16034525&form=6&db=m A phase II study of celecoxib, gemcitabine, and cisplatin in advanced pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16035618&form=6&db=m Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16042585&form=6&db=m Is COX-2 a 'collateral' target in cancer prevention? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16044148&form=6&db=m Loss of TNF-alpha-regulated COX-2 expression in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16044407&form=6&db=m Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16049281&form=6&db=m Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16052515&form=6&db=m Enhancement of antitumor activity of docetaxel by celecoxib in lung tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054423&form=6&db=m Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054988&form=6&db=m Nicotine and gastric cancer. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16055866&form=6&db=m COX-2 expression during early lung squamous cell carcinoma oncogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080510&form=6&db=m Cyclooxygenase-2 expression in human soft-tissue sarcomas is related to epithelial differentation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080553&form=6&db=m Cyclooxygenase-2 expression in brain metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16081048&form=6&db=m Evaluation of potential Stat3-regulated genes in human breast cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083499&form=6&db=m Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083713&form=6&db=m Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083714&form=6&db=m Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16091477&form=6&db=m Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16092118&form=6&db=m Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16093422&form=6&db=m Upregulation of cyclooxygenase-2 and thromboxane A2 production mediate the action of tumor necrosis factor-alpha in isolated rat myenteric ganglia. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16094269&form=6&db=m Effect of mechanical compression on the lumbar nerve root: localization and changes of intraradicular inflammatory cytokines, nitric oxide, and cyclooxygenase. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16094702&form=6&db=m Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: possible role in tumor promotion and angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16097070&form=6&db=m Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16097073&form=6&db=m Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16098373&form=6&db=m NS-398, a selective cyclooxygenase-2 inhibitor, reduces experimental bladder carcinoma outgrowth by inhibiting tumor cell proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16099783&form=6&db=m The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16100520&form=6&db=m Potential use of COX-2-aromatase inhibitor combinations in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16101131&form=6&db=m Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16104877&form=6&db=m Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16107267&form=6&db=m Inhibition of cyclooxygenase-2 enhances myocardial damage in a mouse model of viral myocarditis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16111807&form=6&db=m Elevation of cyclooxygenase-2 is related to lymph node metastasis in adenocarcinoma of uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113051&form=6&db=m Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115226&form=6&db=m Expression of type V secretory phospholipase A in myocardial remodelling after infarction. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115610&form=6&db=m Cellular and molecular biology of prostacyclin synthase. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115920&form=6&db=m Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115954&form=6&db=m Levels of prostaglandin E metabolite, the major urinary metabolite of prostaglandin E2, are increased in smokers. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16118231&form=6&db=m Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16118353&form=6&db=m Prostaglandins and cancer. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16119982&form=6&db=m Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16123581&form=6&db=m Cyclooxygenase-2 and Angiogenesis in Prostate Cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16124396&form=6&db=m Role of COX-2 selective inhibitors for prevention and treatment of cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16126263&form=6&db=m Cytoplasmic HuR expression correlates with epithelial cancer cell but not with stromal cell cyclooxygenase-2 expression in mucinous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127422&form=6&db=m Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16131446&form=6&db=m Localisation of COX-2 protein is different in breast ductal carcinoma and adjacent non-tumour ductal epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16132759&form=6&db=m Cyclooxygenase-2 expression increases with the stage and grade in transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16133570&form=6&db=m Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16134002&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib is a potent inhibitor of human carbonic anhydrase II. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136511&form=6&db=m COX-2 overexpression in canine tumors: potential therapeutic targets in oncology. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136747&form=6&db=m Differential protein expression between esophageal squamous cell carcinoma and dysplasia, and prognostic significance of protein markers. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139560&form=6&db=m Hepatocyte growth factor expression correlates with cyclooxygenase-2 pathway in human salivary gland tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139847&form=6&db=m Anthocyanins in Cornus alternifolia, Cornus controversa, Cornus kousa and Cornus florida fruits with health benefits. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140976&form=6&db=m Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16142306&form=6&db=m The effects of non-selective, preferential-selective and selective COX-inhibitors on the growth of experimental and human tumors in mice related to prostanoid receptors. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16144930&form=6&db=m Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16150282&form=6&db=m Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16151811&form=6&db=m Gemcitabine plus celecoxib (GECO) in advanced pancreatic cancer: a phase II trial. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16164044&form=6&db=m Prognostic importance of COX-2 expression in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166455&form=6&db=m Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167259&form=6&db=m [Relationship between cyclooxygenase- 2 expression and angiogenesis in patients with gastric cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167260&form=6&db=m [COX- 2 expression in gastric cancer and its relationship with lymphangiogenesis and lymph node metastasis] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16168133&form=6&db=m Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16168844&form=6&db=m Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16174078&form=6&db=m Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16175586&form=6&db=m Adenocarcina of the mouse prostate growth inhibition by celecoxib: downregulation of transcription factors involved in COX-2 inhibition. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16175974&form=6&db=m Cyclooxygenase-2 expression in Warthin's tumour. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16177193&form=6&db=m Human fecal water inhibits COX-2 in colonic HT-29 cells: role of phenolic compounds. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16178816&form=6&db=m New indications for established drugs: combined tumor-stroma-targeted cancer therapy with PPARgamma agonists, COX-2 inhibitors, mTOR antagonists and metronomic chemotherapy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16180730&form=6&db=m Gene expression of factors related to the immune reaction in response to intramammary Escherichia coli lipopolysaccharide challenge. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16182328&form=6&db=m Antineoplastic effect of the cyclooxygenase inhibitor meloxicam on canine osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16182442&form=6&db=m Oncogenic action of phospholipase A2 in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16186186&form=6&db=m Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16188370&form=6&db=m The cyclooxygenase-2 inhibitor rofecoxib (Vioxx) in the treatment of cervical dysplasia grade II-III A phase II trial. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16193234&form=6&db=m Patterns and localization of gene expression during intramembranous bone regeneration in the rat femoral marrow ablation model. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16194481&form=6&db=m [COX-2 inhibitors in cancer prevention] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16199309&form=6&db=m Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16201851&form=6&db=m Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202549&form=6&db=m Anti-inflammatory activity of four Bolivian Baccharis species (Compositae). diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202616&form=6&db=m Ionizing radiation induces astrocyte gliosis through microglia activation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202995&form=6&db=m Cyclooxygenase-2 is over-expressed in Chinese esophageal squamous cell carcinoma, and correlated with NF-kappaB: an immunohistochemical study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16203768&form=6&db=m The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16203791&form=6&db=m Radiation sensitivity of human carcinoma cells transfected with small interfering RNA targeted against cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204019&form=6&db=m A functional role for hemostasis in early cancer development. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204198&form=6&db=m Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16205694&form=6&db=m Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16210875&form=6&db=m Cyclooxygenase-2 inhibition prevents colorectal cancer: from the bench to the bed side. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213894&form=6&db=m Synergistic tumoricidal effect between celecoxib and adenoviral-mediated delivery of mda-7 in human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16214108&form=6&db=m Targeted inhibition of p38alpha MAPK suppresses tumor-associated endothelial cell migration in response to hypericin-based photodynamic therapy. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16216410&form=6&db=m Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16218400&form=6&db=m [Relationship between cyclooxygenase (COX)-2 and malignant tumors] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219634&form=6&db=m Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219637&form=6&db=m Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16226380&form=6&db=m beta-catenin-mediated signaling: A novel molecular target for chemoprevention with anti-inflammatory substances. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16226725&form=6&db=m The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16227405&form=6&db=m Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16227602&form=6&db=m Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16230370&form=6&db=m Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 transgenic mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16230415&form=6&db=m Radiosensitivity enhancement by celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, via COX-2-dependent cell cycle regulation on human cancer cells expressing differential COX-2 levels. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16237957&form=6&db=m Tumor initiation inhibition through inhibition COX-1 activity of a traditional Korean herbal prescription, Geiji-Bokryung-Hwan, in human hepatocarcinoma cells. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16239969&form=6&db=m Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16240325&form=6&db=m The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16246405&form=6&db=m Prevalence and prognostic significance of COX-2 expression in stage IB cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16246585&form=6&db=m Cloning and expression of TNF-alpha, IL-1beta and COX-2 in an anadromous and landlocked strain of Atlantic salmon (Salmo salar L.) during the smolting period. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247189&form=6&db=m Prostaglandins as mediators of COX-2 derived carcinogenesis in gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16247750&form=6&db=m Overexpression of cyclooxygenase-2 in multiple myeloma: association with reduced survival. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16250846&form=6&db=m Pharmacological intervention of cyclooxygenase-2 and 5-lipoxygenase pathways. Impact on inflammation and cancer. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16255020&form=6&db=m Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256450&form=6&db=m Systemic bone loss and induction of coronary vessel disease in a rat model of chronic inflammation. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16256796&form=6&db=m Dimethyl celecoxib as a novel non-cyclooxygenase 2 therapy in the treatment of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16260857&form=6&db=m Overexpression of cyclooxygenase-2 in gastric cancer correlates with the high abundance of vascular endothelial growth factor-C and lymphatic metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16263508&form=6&db=m Induction of proinflammatory cytokines and C-reactive protein in human macrophage cell line U937 exposed to air pollution particulates. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16264935&form=6&db=m Mechanisms of disease: Inflammatory mediators and cancer prevention. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16265072&form=6&db=m Mechanisms of disease: Carcinogenesis in Barrett's esophagus. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16265882&form=6&db=m Targeting cyclooxygenase-2 for cancer prevention and treatment. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16266236&form=6&db=m Cyclooxygenase-2 inhibition in colon experimental carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16267038&form=6&db=m HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16269535&form=6&db=m Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma: involvement of alpha-melanocyte-stimulating hormone-mediated inhibition of the nuclear factor kappaB/cyclooxygenase-2 pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273222&form=6&db=m Expression of p63, COX-2, EGFR and beta-catenin in smokers and patients with squamous cell carcinoma of the head and neck reveal variations in non-neoplastic tissue and no obvious changes in smokers. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273249&form=6&db=m Inhibition of cytotoxicity of cisplatin by cyclooxygenase-2 inhibitor nimesulide in head and neck cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273277&form=6&db=m Anti-angiogenic effects of Hypericin-photodynamic therapy in combination with Celebrex in the treatment of human nasopharyngeal carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16274041&form=6&db=m [NS398 induced apoptosis in pancreatic carcinoma cell strain BxPC-3 through a COX-2-in dependent pathway] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16276519&form=6&db=m Gamma-herpesvirus neoplasia: a growing role for COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16277432&form=6&db=m Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16279229&form=6&db=m [Cyclooxygenases in the skin] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16282507&form=6&db=m Multifocal angiostatic therapy: an update. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16285555&form=6&db=m [Relationship between the expression of cyclooxygenase-2 and microvessel density in oral squamnous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16287071&form=6&db=m Quantitative analysis of aromatase mRNA expression derived from various promoters (I.4, I.3, PII and I.7) and its association with expression of TNF-alpha, IL-6 and COX-2 mRNAs in human breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16293616&form=6&db=m Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16299228&form=6&db=m Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16301573&form=6&db=m Cyclooxygenase-2 expression is associated with histologic tumor type in canine mammary carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16302726&form=6&db=m Multiple roles of cyclooxygenase-2 in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16309227&form=6&db=m Cox-2 levels in canine mammary tumors, including inflammatory mammary carcinoma: clinicopathological features and prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16311241&form=6&db=m Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314343&form=6&db=m Expression of cyclooxygenase-2 and matrix metalloproteinase-9 in gastric carcinoma and its correlation with angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16317264&form=6&db=m Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16319132&form=6&db=m Sphingosine kinase 1 is up-regulated in colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16319525&form=6&db=m Prostaglandin E(2) Drives Cyclooxygenase-2 Expression via Cyclic AMP Response Element Activation in Human Pancreatic Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322294&form=6&db=m High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322342&form=6&db=m Zoledronic acid cooperates with a cyclooxygenase-2 inhibitor and gefitinib in inhibiting breast and prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322898&form=6&db=m Correlation of cyclooxygenase-2 and aromatase immunohistochemical expression in invasive ductal carcinoma, ductal carcinoma in situ, and adjacent normal epithelium. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16324362&form=6&db=m [Correlation between Stat3 signal transduction pathway and expression of cyclooxygenase-2 in colorectal cancer cells] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16326073&form=6&db=m Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16326423&form=6&db=m Effect of alpha-tocopherol on the expression of hepatic vascular stress genes in response to sepsis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16327494&form=6&db=m Neoadjuvant selective COX-2 inhibition down-regulates important oncogenic pathways in patients with esophageal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16328030&form=6&db=m Clinical implications of expression of cyclooxygenase-2 related to angiogenesis in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16331615&form=6&db=m Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16331686&form=6&db=m Prostaglandin E(2) receptor EP(1) transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16332992&form=6&db=m Anti-inflammatory mechanisms of phenanthroindolizidine alkaloids. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16334139&form=6&db=m Cyclooxygenase-2 protein expression in relation to apoptotic potential and its prognostic significance in bladder urothelial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16336399&form=6&db=m Aspirin induces apoptosis in oesophageal cancer cells by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16337272&form=6&db=m Changes in gene expression contribute to cancer prevention by COX inhibitors. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16339564&form=6&db=m Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16343055&form=6&db=m Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16343343&form=6&db=m Association between frequent use of nonsteroidal anti-inflammatory drugs and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16344070&form=6&db=m erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16352617&form=6&db=m Significance of COX-2 expression in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16353170&form=6&db=m Microsomal prostaglandin E2 synthase-1 in breast cancer: a potential target for therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16356124&form=6&db=m Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16356838&form=6&db=m Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357153&form=6&db=m Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16361154&form=6&db=m [Expression of COX-2 protein in colorectal carcinoma and the clinical implication] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16361272&form=6&db=m Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16361565&form=6&db=m Antitumor efficacy of capecitabine and celecoxib in irradiated and lead-shielded, contralateral human BxPC-3 pancreatic cancer xenografts: clinical implications of abscopal effects. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16368644&form=6&db=m Radiation treatment of acute inflammation in mice. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16369983&form=6&db=m Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16371352&form=6&db=m Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16371738&form=6&db=m Lymphovascular invasion is associated with poor survival in gastric cancer: an application of gene-expression and tissue array techniques. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16374068&form=6&db=m Overexpression of cyclooxygenase-2 is associated with a favorable prognostic phenotype in breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376111&form=6&db=m NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376136&form=6&db=m Amphiregulin as a tumor promoter for oral squamous cell carcinoma: involvement of cyclooxygenase 2. diagnostic usage,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376882&form=6&db=m Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16380122&form=6&db=m Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16382040&form=6&db=m Studies into the Anticancer Effects of Selenomethionine against Human Colon Cancer. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391819&form=6&db=m COX-2 induction by heparanase in the progression of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391822&form=6&db=m The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391837&form=6&db=m Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391871&form=6&db=m Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16394872&form=6&db=m Preferential expression of cyclooxygenase-2 in colonic-phenotype of gastric intestinal metaplasia: association with helicobacter pylori and gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16395701&form=6&db=m Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16397045&form=6&db=m Cycloxygenase-2 inhibition augments the efficacy of a cancer vaccine. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16397051&form=6&db=m Mechanical analysis of tumor growth regression by the cyclooxygenase-2 inhibitor, DFU, in a Walker256 rat tumor model: importance of monocyte chemoattractant protein-1 modulation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16397216&form=6&db=m Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16399429&form=6&db=m Commentary: targeting colorectal cancer through molecular biology. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16400521&form=6&db=m Cyclooxygenase inhibition in early onset of tumor growth and related angiogenesis evaluated in EP1 and EP3 knockout tumor-bearing mice. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16401921&form=6&db=m Relation between cyclooxygenase-2 expression and clinicopathologic parameters with patient prognosis in transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16404132&form=6&db=m Anti-arthritic effects of Ephedra sinica STAPF herb-acupuncture: inhibition of lipopolysaccharide-induced inflammation and adjuvant-induced polyarthritis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407821&form=6&db=m Hypoxia induced by benign intestinal epithelial cells is associated with cyclooxygenase-2 expression in stromal cells through AP-1-dependent pathway. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16409625&form=6&db=m The selective Cox-2 inhibitor Celecoxib suppresses angiogenesis and growth of secondary bone tumors: an intravital microscopy study in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16413115&form=6&db=m 9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16413410&form=6&db=m Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16413466&form=6&db=m Connecting COX-2 and Wnt in cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415009&form=6&db=m Epstein-Barr virus protein can upregulate cyclo-oxygenase-2 expression through association with the suppressor of metastasis Nm23-H1. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16416602&form=6&db=m Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16418805&form=6&db=m COX-2 Inhibitors Modulate IL-12 Signaling Through JAK-STAT Pathway Leading to Th1 Response in Experimental Allergic Encephalomyelitis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16420297&form=6&db=m In vitro effects of meloxicam with or without doxorubicin on canine osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16420789&form=6&db=m [Cyclooxygenase-2 expression as a prognostic factor in sporadic colorectal cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16421596&form=6&db=m Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424000&form=6&db=m Protein kinase C delta overexpressing transgenic mice are resistant to chemically but not to UV radiation-induced development of squamous cell carcinomas: a possible link to specific cytokines and cyclooxygenase-2. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424017&form=6&db=m Roles of myofibroblasts in prostaglandin E2-stimulated intestinal epithelial proliferation and angiogenesis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16424911&form=6&db=m Expression of antiapoptotic and proapoptotic molecules in diabetic retinas. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16425990&form=6&db=m Cyclooxygenase-2: a therapeutic target for prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16426736&form=6&db=m Expression of COX-2 in normal and pyelonephritic kidney, renal intraepithelial neoplasia, and renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16427185&form=6&db=m COX-2 expression in pseudomyxoma peritonei. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16428068&form=6&db=m Accelerative effect of a selective cyclooxygenase-2 inhibitor on Fas-mediated apoptosis in human neutrophils. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16430474&form=6&db=m Cell cycle regulators and apoptosis-associated proteins in relation to proliferative activity and degree of apoptosis in HNPCC versus sporadic endometrial carcinoma. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16432453&form=6&db=m Expression of cyclooxygenase-2 in benign naevi and during human cutaneous melanoma progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16434425&form=6&db=m Insulin-like growth factor I improves intestinal barrier function in cirrhotic rats. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16443262&form=6&db=m Maspin expression and localization impact on angiogenesis and prognosis in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16444599&form=6&db=m tNOX, an alternative target to COX-2 to explain the anticancer activities of non-steroidal anti-inflammatory drugs (NSAIDS). diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16452236&form=6&db=m The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16455468&form=6&db=m Cyclooxygenase-2 expression and clinical outcome in gastrointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456379&form=6&db=m Chronic obstructive pulmonary disease: effects beyond the lungs. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16457848&form=6&db=m COX-2 induces IL-11 production in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16463383&form=6&db=m Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16467169&form=6&db=m Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474181&form=6&db=m Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474375&form=6&db=m Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474989&form=6&db=m Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16475165&form=6&db=m Knockdown of NFAT3 blocked TPA-induced COX-2 and iNOS expression, and enhanced cell transformation in Cl41 cells. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16476053&form=6&db=m Differential modulatory effects of Annexin 1 on nitric oxide synthase induction by lipopolysaccharide in macrophages. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16482921&form=6&db=m [Expression of cyclooxygenase (COX)-2 in astrocytic tumors and anti-tumor effects of selective COX-2 inhibitors] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16483484&form=6&db=m [Expression of vascular endothelial growth factor C and cyclooxygenase-2 in non-small-cell lung carcinoma and their clinical significance.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16483797&form=6&db=m The effects of Lepeophtheirus salmonis infections on the stress response and immunological status of Atlantic salmon (Salmo salar). ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16487513&form=6&db=m Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489006&form=6&db=m Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489098&form=6&db=m The Cyclooxygenase-2 (PTGS2) 8473T>C Polymorphism is Associated with Breast Cancer Risk. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16489179&form=6&db=m COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16494037&form=6&db=m [The expressiong of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16497869&form=6&db=m Overexpression of cyclo-oxygenase-2 is an independent predictor of unfavourable outcome in node-negative breast cancer, but is not associated with protein kinase B (Akt) and mitogen-activated protein kinase (ERK1/2, p38) activation or with Her-2/neu signalling pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16497971&form=6&db=m Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16500554&form=6&db=m Dietary fatty acids modulate chronic colitis, colitis-associated colon neoplasia and COX-2 expression in IL-10 knockout mice. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507389&form=6&db=m Aberrant methylation of cyclooxygenase-2 in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507390&form=6&db=m Celecoxib induces dose dependent growth inhibition in nasopharyngeal carcinoma cell lines independent of cyclooxygenase-2 expression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507391&form=6&db=m COX-2 inhibitors act as radiosensitizer in tumor treatment. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507392&form=6&db=m Curcumin synergistically potentiates the growth inhibitory and pro-apoptotic effects of celecoxib in pancreatic adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507393&form=6&db=m Current directions for COX-2 inhibition in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507394&form=6&db=m Cyclooxygenase-2 expression is associated with VEGF-C and lymph node metastases in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507395&form=6&db=m Cyclooxygenase-2 inhibitors suppress angiogenesis and growth of gastric cancer xenografts. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507397&form=6&db=m Study of COX-2, Ki67, and p53 expression to predict effectiveness of 5-flurouracil, epirubicin and cyclophosphamide with celecoxib treatment in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507398&form=6&db=m Serum lipid profiles in patients receiving endocrine treatment for breast cancer-the results from the Celecoxib Anti-Aromatase Neoadjuvant (CAAN) Trial. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507399&form=6&db=m Taxanes and COX-2 inhibitors: from molecular pathways to clinical practice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507400&form=6&db=m The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16508938&form=6&db=m Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: Regulation of synovial proliferation and inflammatory gene expression. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510568&form=6&db=m Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510588&form=6&db=m FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510608&form=6&db=m Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16513308&form=6&db=m Herbal formulation, Yukmi-jihang-tang-Jahage, regulates bone resorption by inhibition of phosphorylation mediated by tyrosine kinase Src and cyclooxygenase expression. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16515599&form=6&db=m Expression of cyclooxygenase-2 in epithelial ovarian tumors and its relation to vascular endothelial growth factor and p53 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16518418&form=6&db=m Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2, inducible nitric oxide synthase, and hypoxia-inducible factor 1alpha expression, resulting in reduced angiogenesis. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16519157&form=6&db=m [Expression and implication of cyclooxygenase-2 mRNA in prostate cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16520894&form=6&db=m Pioglitazone, a synthetic ligand for PPARgamma, induces apoptosis in RB-deficient human colorectal cancer cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522694&form=6&db=m Phase II study of celecoxib in metastatic differentiated thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525617&form=6&db=m [The antimicrobial effects of chitosans on oral pathogenic microbes in vitro.] ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16527254&form=6&db=m Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16528365&form=6&db=m Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16531064&form=6&db=m Cyclooxygenase-2 as a target for anticancer drug development. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16532483&form=6&db=m Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16534415&form=6&db=m Defective Arachidonate Release and PGE2 Production in Gialpha2-Deficient Intestinal and Colonic Subepithelial Myofibroblasts. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16538539&form=6&db=m COX-2 expression in canine and feline invasive mammary carcinomas: correlation with clinicopathological features and prognostic molecular markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16540639&form=6&db=m Prostaglandin E Receptor EP4 Antagonism Inhibits Breast Cancer Metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16543625&form=6&db=m Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550520&form=6&db=m Antitumor effects of celecoxib on K562 leukemia cells are mediated by cell-cycle arrest, caspase-3 activation, and downregulation of Cox-2 expression and are synergistic with hydroxyurea or imatinib. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550596&form=6&db=m Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16550738&form=6&db=m Inducible cyclooxygenase (COX-2) in glioblastoma--clinical and immunohistochemical (COX-2-VEGF) correlations. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16551850&form=6&db=m Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552621&form=6&db=m Inhibition of human neuroblastoma in SCID mice by low-dose of selective Cox-2 inhibitor nimesulide. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552798&form=6&db=m Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: a review and report of personal experience. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552960&form=6&db=m [Ease-2 and inducible nitric oxide synthase in tongue hyperplasia and tongue squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16556483&form=6&db=m Quantitative analysis of aromatase, sulfatase and 17beta-HSD(1) mRNA expression in soft tissue metastases of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16557554&form=6&db=m COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16557574&form=6&db=m Chenodeoxycholic acid stimulates the progression of human esophageal cancer cells: A possible mechanism of angiogenesis in patients with esophageal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16557596&form=6&db=m Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrence. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16564923&form=6&db=m Cyclooxygenase-2 overexpression associated with a poor prognosis in chondrosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16570043&form=6&db=m COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16571133&form=6&db=m Cyclooxygenase expression is not required for release of arachidonic acid from cells by some nonsteroidal anti-inflammatory drugs and cancer preventive agents. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16572323&form=6&db=m Antiproliferative effect of indomethacin on CML cells is related to the suppression of STATs/Bcl-XL signal pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16572448&form=6&db=m Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16572897&form=6&db=m P53, COX-2, iNOS protein expression changes and their relationship with anti-oxidant enzymes in surgically and multi-modality treated esophageal carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16580341&form=6&db=m Cyclooxygenase-2, angiogenesis, tumor cell proliferation, P-glycoprotein in advanced ovarian serous carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16582683&form=6&db=m Update on nonsteriodal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16584632&form=6&db=m Preliminary proteomic analysis of indomethacin's effect on tumor transplanted with colorectal cancer cell in nude mice. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16585150&form=6&db=m Using chemopreventive agents to enhance the efficacy of cancer therapy. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16585199&form=6&db=m Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16597032&form=6&db=m [Expression of cyclooxygenase-2 and vascular endothelial growth factor in human prostate cancer and its significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16597647&form=6&db=m GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16597712&form=6&db=m A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16607618&form=6&db=m Photodynamic therapy: combined modality approaches targeting the tumor microenvironment. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16609907&form=6&db=m Pathological function of prostaglandin E2 receptors in transitional cell carcinoma of the upper urinary tract. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16610702&form=6&db=m Chronic inflammation and pathogenesis of GI and pancreatic cancers. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16612714&form=6&db=m COX-2 and preoperative CA-125 level are strongly correlated with survival and clinical responsiveness to chemotherapy in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16613672&form=6&db=m [Inhibitory Effects of Cyclooxygenase-2 Inhibitor Celecoxib on Growth and Angiogenesis of Human Liver Cancer HepG2 Cell Xenografts in Small Nude Mice.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16615003&form=6&db=m Effects of cyclooxygenase-2 inhibition on serum and tumor gastrins and expression of apoptosis-related proteins in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618699&form=6&db=m Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618763&form=6&db=m Inhibition of Cyclooxygenase-2 Disrupts Tumor Vascular Mural Cell Recruitment and Survival Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619186&form=6&db=m Suppression of Prostaglandin E2 by Malaria Parasite Products and Antipyretics Promotes Overproduction of Tumor Necrosis Factor- alpha : Association with the Pathogenesis of Childhood Malarial Anemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619484&form=6&db=m Conjugated linoleic acid (CLA) modulates prostaglandin E2 (PGE2) signaling in canine mammary cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619534&form=6&db=m Celecoxib induces regression of putative preneoplastic lesions in rat liver. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619662&form=6&db=m Induction of macrophagic prostaglandin E2 synthesis by glioma cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622306&form=6&db=m COX-1 and -2 expressions in sex-related organs of neonatally estrogen-treated rats and in activated and nonactivated macrophage RAW264.7 cells with phytoestrogen. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622456&form=6&db=m RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627914&form=6&db=m Cyclooxygenase-2 and thromboxane synthase in non-endocrine and endocrine tumors: a review. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632477&form=6&db=m Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16632868&form=6&db=m Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16636478&form=6&db=m Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16641552&form=6&db=m Inhibition of Akt/PKB by a COX-2 inhibitor induces apoptosis in gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16641887&form=6&db=m Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16650963&form=6&db=m Cyclo-oxygenase-2 (COX-2) mRNA expression and hormone receptor status in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16669452&form=6&db=m Elevated cyclooxygenase-2 expression is associated with histological grade in invasive ductal breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677165&form=6&db=m Influences of Helicobacter pylori on cyclooxygenase-2 expression and prostaglandinE2 synthesis in rat gastric epithelial cells in vitro. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677508&form=6&db=m [Effects of inhibition of cyclooxygenase-2 by RNA interference on proliferation and apoptosis of human gastric cancer cells: an experimental study with human gastric cancer cells and mice] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16678856&form=6&db=m Involvement of IL-8 in COX-2-mediated bone metastases from breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16681724&form=6&db=m Expression of cyclooxygenase-2 and inducible nitric oxide synthase in ovarian surface epithelial carcinomas: is there any correlation with angiogenesis or clinicopathologic parameters? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16681759&form=6&db=m Increased cyclooxygenase-2 expression is correlated with suppressed antitumor immunity in cervical adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16682957&form=6&db=m Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685147&form=6&db=m Differential protein expression in the epidermis of wild-type and COX-2 transgenic mice. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16685273&form=6&db=m Prostaglandin E(2) stimulates progression-related gene expression in early colorectal adenoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16688727&form=6&db=m Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16698151&form=6&db=m Intestinal anti-inflammatory activity of combined quercitrin and dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, in rats with DSS-induced colitis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16699180&form=6&db=m The adenomatous polyposis coli tumor suppressor gene regulates expression of cyclooxygenase-2 by a mechanism that involves retinoic acid. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16700663&form=6&db=m Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16702519&form=6&db=m Molecular determinants in targeted therapy for esophageal adenocarcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707021&form=6&db=m Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707460&form=6&db=m Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707480&form=6&db=m HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16709027&form=6&db=m Antitumor properties of dimethyl-celecoxib, a derivative of celecoxib that does not inhibit cyclooxygenase-2: implications for glioma therapy. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16709411&form=6&db=m Upregulation of thromboxane synthase in human colorectal carcinoma and the cancer cell proliferation by thromboxane A2. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712447&form=6&db=m Cyclooxygenase-2 inhibitors and cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712448&form=6&db=m Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: topical therapeutic strategies targeting COX-2 expression and activity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712449&form=6&db=m The potential and rationale for COX-2 inhibitors in lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712451&form=6&db=m The use of nimesulide and its analogues in cancer chemoprevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712452&form=6&db=m A computational view of COX-2 inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712734&form=6&db=m Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16714876&form=6&db=m [Cyclo-oxygenase-2 and p53 immunoreactivity in superficial early colorectal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16718377&form=6&db=m NFAT3 is Required for EGF-Induced COX-2 Transcription, but Neither iNOS Transcription Nor Cell Transformation in Cl 41 Cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16720448&form=6&db=m Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16724691&form=6&db=m Association of cyclooxygenase-2 immunoreactivity with tumor recurrence and disease progression in superficial urothelial bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16724692&form=6&db=m Tumor cyclooxygenase-2 gene suppresses local immune responses in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16728574&form=6&db=m VEGF-C and COX-2 expression in papillary thyroid cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731602&form=6&db=m MMP-2 but not MMP-9 associated with COX-2 and survival in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731743&form=6&db=m RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16732324&form=6&db=m EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16735371&form=6&db=m Association between cyclooxygenase-2 and matrix metalloproteinase-2 expression in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16740761&form=6&db=m A phase I trial to determine the optimal biological dose of celecoxib when combined with erlotinib in advanced non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16750334&form=6&db=m Expression of the p73 protein in rectal cancers with or without preoperative radiotherapy. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16752205&form=6&db=m Cyclooxygenase-2 expression correlates with membrane-type-1 matrix metalloproteinase expression in colorectal cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16755536&form=6&db=m Resampling-based multiple hypothesis testing procedures for genetic case-control association studies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16757341&form=6&db=m Ras up-regulation of cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16757698&form=6&db=m Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16759529&form=6&db=m [Detection of expression of p53, p16, and cyclooxygenase 2 in pancreatic cancer by tissue microarray and correlation among these three genes] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16760271&form=6&db=m Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762006&form=6&db=m Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762637&form=6&db=m Preinvasive duct-derived neoplasms in pancreas of keratin 5-promoter cyclooxygenase-2 transgenic mice. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762640&form=6&db=m COX-2 and gastric cancer: More on inflammation and neoplasia. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16769709&form=6&db=m Comparative immunoproteomics of identification and characterization of virulence factors from Helicobacter pylori related to gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16770015&form=6&db=m Activation of cerebral peroxisome proliferator-activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16772565&form=6&db=m Leukocyte populations and mRNA expression of inflammatory factors in quarter milk fractions at different somatic cell score levels in dairy cows. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16775385&form=6&db=m Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16776905&form=6&db=m Cyclooxygenase-2 (COX-2) immunostaining does not correlate with the degree of vulvar neoplasia. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778222&form=6&db=m Changes in antitumor response in C57BL/6J-Min/+ mice during long-term administration of a selective cyclooxygenase-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778966&form=6&db=m [Inhibiting cerebral glioma growth with continuous low-dose chemotherapy and cyclooxygenase-2 inhibitor in nude mice] diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785824&form=6&db=m Cyclooxygenase-2 inhibition and coagulation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16786154&form=6&db=m COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16788158&form=6&db=m Effect of silibinin on the growth and progression of primary lung tumors in mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16788159&form=6&db=m Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16790433&form=6&db=m Modulation of Stat3 activation by the cytosolic phospholipase A2alpha and cyclooxygenase-2-controlled prostaglandin E2 signaling pathway. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797120&form=6&db=m Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797158&form=6&db=m Cox-2 expression on tissue microarray of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797680&form=6&db=m Cyclooxygenase 1 and 2 mRNA and protein expression in the Gallus domesticus model of ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16799479&form=6&db=m Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16800774&form=6&db=m Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16803521&form=6&db=m COX-1 and COX-2 expression in stage I and II invasive cervical carcinoma: relationship to disease relapse and long-term survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806797&form=6&db=m Increases in circulating VEGF levels during COX-2 inhibitor treatment in breast cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16809336&form=6&db=m Cyclooxygenase-2 induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818501&form=6&db=m Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818637&form=6&db=m The crucial role of cyclooxygenase-2 in osteopontin-induced protein kinase C alpha/c-Src/IkappaB kinase alpha/beta-dependent prostate tumor progression and angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818642&form=6&db=m Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818886&form=6&db=m A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16819292&form=6&db=m Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820089&form=6&db=m Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820889&form=6&db=m PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820896&form=6&db=m Expression of COX-2 and steroid converting enzymes in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16822500&form=6&db=m NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16823844&form=6&db=m COX-2 upregulation in thymomas and thymic carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16824926&form=6&db=m Celecoxib inhibits cellular growth, decreases Ki-67 expression and modifies apoptosis in ovarian cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16835344&form=6&db=m A multiplex tissue immunoblotting assay for proteomic profiling: a pilot study of the normal to tumor transition of esophageal squamous cell carcinoma. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16837203&form=6&db=m Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16841079&form=6&db=m The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16842132&form=6&db=m Cyclooxygenases in cancer: chemoprevention and sensitization to conventional therapies. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16842185&form=6&db=m Roles of prostanoids in colon carcinogenesis and their potential targeting for cancer chemoprevention. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16842597&form=6&db=m UVB-induced interleukin-18 production is downregulated by tannic acids in human HaCaT keratinocytes. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16844092&form=6&db=m Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16847764&form=6&db=m Clinical significance of cyclooxygenase-2 (COX-2) in multiple myeloma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16848520&form=6&db=m Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849551&form=6&db=m Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16849589&form=6&db=m Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16859832&form=6&db=m Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16865247&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the oral cavity and pharynx: association to p53 and clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872316&form=6&db=m Expression of cyclo-oxygenase-2 in gastrointestinal carcinoid tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872953&form=6&db=m Perioperative cyclooxygenase 2 inhibition to reduce tumor cell adhesion and metastatic potential of circulating tumor cells in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16880258&form=6&db=m Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16880406&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16884383&form=6&db=m Overexpression of cyclooxygenase-2 correlates with tumor angiogenesis in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16885386&form=6&db=m 15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16888001&form=6&db=m Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16890383&form=6&db=m Heparanase promotes angiogenesis through Cox-2 and HIF1alpha. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892400&form=6&db=m Detection of Overexpressed COX-2 in Precancerous Lesions of Hamster Pancreas and Lungs by Molecular Imaging: Implications for Early Diagnosis and Prevention. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16893539&form=6&db=m Inhibition of cyclooxygenase (COX)-2 affects endothelial progenitor cell proliferation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16898866&form=6&db=m Chemopreventive effects of dietary flaxseed on colon tumor development. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899364&form=6&db=m Role of prostaglandin E2 in the invasiveness, growth and protection of cancer cells in malignant pleuritis. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899616&form=6&db=m Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900533&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900783&form=6&db=m Cyclooxygenase-2 (COX-2) overexpression in childhood brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16908593&form=6&db=m Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16909108&form=6&db=m Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16916756&form=6&db=m More than structural cells, fibroblasts create and orchestrate the tumor microenvironment. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16919462&form=6&db=m Antioxidant and anti-inflammatory activities of N-acetyldopamine dimers from Periostracum Cicadae. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16919832&form=6&db=m 4-O-Methylgallic acid suppresses inflammation-associated gene expression by inhibition of redox-based NF-kappaB activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16921484&form=6&db=m What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis? causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16925606&form=6&db=m Pathogenesis of Helicobacter pylori Infection. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16930561&form=6&db=m Suppression of endotoxin-induced proinflammatory responses by citrus pectin through blocking LPS signaling pathways. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935971&form=6&db=m Decreased xanthine oxidoreductase is a predictor of poor prognosis in early-stage gastric cancer. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16937518&form=6&db=m Cyclooxygenases in hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16938519&form=6&db=m The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16940413&form=6&db=m Eriocalyxin B inhibits nuclear factor-kappaB activation by interfering with the binding of both p65 and p50 to the response element in a noncompetitive manner. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16943400&form=6&db=m Celecoxib for the prevention of sporadic colorectal adenomas. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16943401&form=6&db=m Celecoxib for the prevention of colorectal adenomatous polyps. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16945549&form=6&db=m Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: from lab to clinic. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16945639&form=6&db=m Expression of cyclooxygenase-2 in Wilms tumor: immunohistochemical study using tissue microarray methodology. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16946499&form=6&db=m Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949556&form=6&db=m Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949912&form=6&db=m Infrequent COX-2 expression due to promoter hypermethylation in gastric cancers in Dalian, China. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16950795&form=6&db=m cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16956889&form=6&db=m Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16962507&form=6&db=m Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling Lee A, Frischer J, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Bender JG, Kandel JJ, Yamashiro DJ, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16963204&form=6&db=m Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16964764&form=6&db=m Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966438&form=6&db=m Altered Expression of {beta}-catenin, E-cadherin, Cycloxygenase-2, and p53 Protein by Ovine Intestinal Adenocarcinoma Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966442&form=6&db=m Cyclooxygenase-2 expression in normal and neoplastic canine mammary cell lines. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966444&form=6&db=m Transitional Cell Carcinoma in Fishing Cats (Prionailurus viverrinus): Pathology and Expression of Cyclooxygenase-1, -2, and p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16967149&form=6&db=m [Cox-2 and CD105 expression in breast cancer and disease-free survival.] diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16969492&form=6&db=m Cyclooxygenase-2 inhibitor, nimesulide, improves radiation treatment against non-small cell lung cancer both in vitro and in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979845&form=6&db=m Cyclooxygenase-2 impairs treatment effects of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979925&form=6&db=m Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979927&form=6&db=m Cyclooxygenase-2 expression in advanced nasopharyngeal carcinoma--a prognostic evaluation and correlation with hypoxia inducible factor 1alpha and vascular endothelial growth factor. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980601&form=6&db=m Temozolomide in combination with celecoxib in patients with advanced melanoma. A phase II study of the Hellenic Cooperative Oncology Group. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16983334&form=6&db=m Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984531&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the esophagus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984600&form=6&db=m Akt expression may predict favorable prognosis in cholangiocarcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16984727&form=6&db=m c-myc amplification is frequent in esophageal adenocarcinoma and correlated with the upregulation of VEGF-A expression. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16989810&form=6&db=m Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16995982&form=6&db=m [A relationship between cyclooxygenase-2 expression and tumor angiogenesis in experimental rat liver carcinogenesis.] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996673&form=6&db=m Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996907&form=6&db=m Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16998298&form=6&db=m [A Case of Complete Regression of Hepatocellular Carcinoma during Administration of COX-2 Inhibitor.] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16999939&form=6&db=m Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17007443&form=6&db=m Cyclooxygenase-2 (cox-2) expression and angiogenesis in intracranial ependymomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17011855&form=6&db=m The expression of cyclooxygenase 2 in retinoblastoma: primary enucleated eyes and enucleation after conservative treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17012253&form=6&db=m Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17013750&form=6&db=m Expression of cyclooxygenase-2 related to angiogenesis in uterine cervical cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016619&form=6&db=m Suppressive effect of non-anaphylactogenic anti-IgE antibody on the development of dextran sulfate sodium-induced colitis. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016639&form=6&db=m Elevated cell migration, invasion and tumorigenicity in human KB carcinoma cells transfected with COX-2 cDNA. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17018624&form=6&db=m Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17021746&form=6&db=m Different matrix micro-environments in colon cancer and diverticular disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17022010&form=6&db=m Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor beta1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17023971&form=6&db=m Barrett's esophagus. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17024120&form=6&db=m The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030179&form=6&db=m Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17033105&form=6&db=m Gastric cancer and Helicobacter pylori infection. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17035596&form=6&db=m Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17037745&form=6&db=m [Effects of nonsteroidal anti-inflammatory drug celecoxib on expression of cyclooxygenase-2 (COX-2) in ovarian carcinoma cell] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17042956&form=6&db=m Alterations of metabolic activity in human osteoarthritic osteoblasts by lipid peroxidation end product 4-hydroxynonenal. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17043422&form=6&db=m Expression of cyclooxygenase-2, p53 and Ki-67 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047037&form=6&db=m Targeting prostaglandin E EP receptors to inhibit metastasis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17047069&form=6&db=m Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049671&form=6&db=m EGFR expression: associations with outcome and clinicopathological variables in malignant pleural mesothelioma. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049779&form=6&db=m Increased expression of cyclooxygenase-2 and Ki-67 are associated with malignant transformation of pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17050345&form=6&db=m mRNA induction and cytokine release of inflammatory mediators during in vitro exposure of human nasal respiratory epithelia to acetaldehyde. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17051370&form=6&db=m Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17052999&form=6&db=m Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17054584&form=6&db=m Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17056201&form=6&db=m A prospective phase I-II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062130&form=6&db=m Polymorphisms within inflammatory genes and colorectal cancer. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17071966&form=6&db=m Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance? unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17073683&form=6&db=m Imaging of cyclooxygenase-2 (COX-2) expression: potential use in diagnosis and drug evaluation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17080719&form=6&db=m Expression of cyclo-oxygenase-2 in ependymal tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084606&form=6&db=m Lipid peroxidation, cyclooxygenase enzyme and tumor cell proliferation inhibitory compounds in Cornus kousa fruits. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17087994&form=6&db=m The activation of gilthead seabream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17093087&form=6&db=m Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17094899&form=6&db=m [Chemopreventive effect of tamoxifen combined with celecoxib on DMBA-induced breast cancer in rats] causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17096325&form=6&db=m Inflammation and IGF-I activate the Akt pathway in breast cancer. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17096355&form=6&db=m Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17098266&form=6&db=m Expression of tumor necrosis factor-alpha and cyclooxygenase-2 mRNA in porcine split-thickness wounds treated with epidermal growth factor by quantitative real-time PCR. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17100552&form=6&db=m NSAIDs and cancer prevention: targets downstream of COX-2. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17100567&form=6&db=m Five-lipoxygenase pathway of arachidonic acid metabolism in carcino-genesis and cancer chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17107625&form=6&db=m Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17118848&form=6&db=m Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17121918&form=6&db=m Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17122632&form=6&db=m An inverse relation between COX-2 and E-cadherin expression correlates with aggressive histologic features in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17126249&form=6&db=m The status of cyclooxygenase-2 expression in ductal carcinoma in situ lesions and invasive breast cancer correlates to cyclooxygenase-2 expression in normal breast tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17127241&form=6&db=m Green tea polyphenols in the prevention of colon cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17128412&form=6&db=m Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17133084&form=6&db=m Chemoprevention of colorectal neoplasia: advances and controversies (the COX-2 story). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17136320&form=6&db=m Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17139447&form=6&db=m Aspirin, TNF-alpha, NFkB, and survival in multiple myeloma: the importance of measuring TNF-alpha. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17141756&form=6&db=m Isatins inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell line. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17142201&form=6&db=m Prognostic factors and COX-2 expression in advanced stage esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17145847&form=6&db=m Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17146741&form=6&db=m COX-2 expression in hepatocellular carcinoma is an initiation event; while EGF receptor expression with downstream pathway activation is a prognostic predictor of survival. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17147116&form=6&db=m [Flow cytometric quantitative analysis of multiple tumor suppressor gene 1 (MTS1) and cyclooxygenase-2 (COX-2) gene expressions in invasive breast cancers and their clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17148503&form=6&db=m Expression of a cyclo-oxygenase-2 transgene in murine liver causes hepatitis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17151092&form=6&db=m Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17159912&form=6&db=m Cyclooxygenase-2 inhibition promotes enhancement of antitumor responses by transcutaneous vaccination with cytosine-phosphate-guanosine-oligodeoxynucleotides and model tumor antigen. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17164142&form=6&db=m The role of cyclooxygenase-2 and prostaglandins in colon cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17165088&form=6&db=m Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17166374&form=6&db=m [Inhibitory effects of Aspisol on growth of transplanted breast cancer in C3H mice] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17166728&form=6&db=m Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17166886&form=6&db=m GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17168813&form=6&db=m The function of the selective inhibitors of cyclooxygenase 2. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17171787&form=6&db=m Microvessel density is a prognostic marker of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17177201&form=6&db=m Celecoxib inhibits meningioma tumor growth in a mouse xenograft model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17177652&form=6&db=m Cyclooxygenase-2 expression determines neo-angiogenesis in gallbladder carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178380&form=6&db=m Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178849&form=6&db=m Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178865&form=6&db=m RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17178883&form=6&db=m Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17179688&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in thyroid neoplasms and their clinicopathological correlation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17182823&form=6&db=m Inflammation, cancer, and targets of ginseng. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17195214&form=6&db=m Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17195456&form=6&db=m Expression of Tn and sialyl-Tn antigens in endometrial cancer: its relationship with tumor-produced cyclooxygenase-2, tumor-infiltrated lymphocytes and patient prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17199422&form=6&db=m Expression of cyclooxygenase-1 and -2 in naturally occurring squamous cell carcinomas in horses. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201121&form=6&db=m COX-independent antineoplastic effects of sulindac in oral cancer are mediated by survivin down-regulation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201140&form=6&db=m COX-2 inhibitor celecoxib suppresses tumor growth and lung metastasis of a murine mammary cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201156&form=6&db=m Curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201164&form=6&db=m Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17201169&form=6&db=m Anticancer potential of silymarin: from bench to bed side. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17202682&form=6&db=m Inhibitory effects of asiatic acid on 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17203971&form=6&db=m Protein expression profiles in the epidermis of cyclooxygenase-2 transgenic mice by 2-dimensional gel electrophoresis and mass spectrometry. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17207320&form=6&db=m Clinicopathological and biological features of DNA tetraploid colorectal cancers. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17209859&form=6&db=m Differential expression of cyclo-oxygenase-2 and nuclear beta-catenin in colorectal cancer tissue. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17213821&form=6&db=m COX-2 involvement in breast cancer metastasis to bone. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214268&form=6&db=m Immediate inflammatory response and scar formation in wounded vocal folds. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214885&form=6&db=m A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17219415&form=6&db=m Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220375&form=6&db=m Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220580&form=6&db=m Cyclo-oxygenase-2 over-expression is associated with human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17220637&form=6&db=m Opioids induce renal abnormalities in tumor-bearing mice. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17222248&form=6&db=m Association of COX-2 expression with corresponding active and chronic inflammatory reactions in Barrett's metaplasia and progression to cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17225564&form=6&db=m Effects of the novel non-steroidal anti-inflammatory compound [N-(2-thiolethyl)-2- {2- [N'- (2,6- dichlorophenyl) amino] phenyl}acetamide on cytokines and apoptosis in ischaemic rat brain. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17229575&form=6&db=m Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17230613&form=6&db=m Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234396&form=6&db=m Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234720&form=6&db=m Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17237818&form=6&db=m Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17241876&form=6&db=m Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17249380&form=6&db=m Cyclooxygenase-2 and tumor biology. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17250449&form=6&db=m Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17250858&form=6&db=m Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae). causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17264535&form=6&db=m Coordinated upregulation of COX-2 and NF-kappaB is a steady feature of laryngeal carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17265445&form=6&db=m Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17269882&form=6&db=m Immunohistochemical evaluation of cyclooxygenase expression in corneal squamous cell carcinoma in horses. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17272310&form=6&db=m Increase of carcinogenic risk via enhancement of cyclooxygenase-2 expression and hydroxyestradiol accumulation in human lung cells as a result of interaction between BaP and 17-beta estradiol. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17274057&form=6&db=m Cyclooxygenase-2 expression in medullary thyroid carcinoma. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17276463&form=6&db=m Role of non-neuronal cholinergic system in breast cancer progression. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17278192&form=6&db=m Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17284248&form=6&db=m Severity of gastritis determines glandular stomach carcinogenesis in Helicobacter pylori-infected Mongolian gerbils. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17284780&form=6&db=m Potential misidentification of cyclooxygenase-2 by Western blot analysis and prevention through the inclusion of appropriate controls. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17285134&form=6&db=m Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17288873&form=6&db=m Cyclooxygenase-2: a novel target in human solid tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17289900&form=6&db=m Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17290397&form=6&db=m EP1-4 subtype, COX and PPAR gamma receptor expression in colorectal cancer in prediction of disease-specific mortality. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291249&form=6&db=m Cyclooxygenase-2 expression in cervical intraepithelial neoplasia III and squamous cell cervical carcinoma, and its correlation with clinicopathologic variables. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17293239&form=6&db=m Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17298411&form=6&db=m Immune regulatory functions of human beta-defensin-2 in odontoblast-like cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17300245&form=6&db=m Repeated low-dose ultraviolet (UV) B exposures of humans induce limited photoprotection against the immune effects of erythemal UVB radiation. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17302183&form=6&db=m Tumor promotion as a target of cancer prevention. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17302187&form=6&db=m Cox-2 and cancer chemoprevention: picking up the pieces. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17305569&form=6&db=m Dual acting anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17305571&form=6&db=m COX-2/5-LOX dual acting anti-inflammatory drugs in cancer chemotherapy. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17305572&form=6&db=m New approaches to the modulation of the cyclooxygenase-2 and 5-lipoxygenase pathways. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308098&form=6&db=m Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308999&form=6&db=m Absence of cyclooxygenase-2 protein expression is a predictor of tumor regression in rectal cancer treated with preoperative short-term chemoradiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17309668&form=6&db=m The prognostic importance of cyclooxygenase 2 and HER2 expression in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17318410&form=6&db=m Induction of COX-2 by acrolein in rat lung epithelial cells. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17323186&form=6&db=m Chemopreventive effect of celecoxib in gastric cancer. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17325901&form=6&db=m Cyclooxygenase-2 expression in non-Hodgkin's lymphomas. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17326157&form=6&db=m Protection against Fas-induced liver apoptosis in transgenic mice expressing cyclooxygenase 2 in hepatocytes. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332308&form=6&db=m Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17337058&form=6&db=m Prostacyclin production is not controlled by prostacyclin synthase but by cyclooxygenase-2 in a human follicular dendritic cell line, HK. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17341442&form=6&db=m Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17341607&form=6&db=m Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17342322&form=6&db=m Failure of apoptosis and activation on NFkappaB by celecoxib and aspirin in lung cancer cell lines. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17342342&form=6&db=m Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on lung cancer: roles of cyclooxygenase-2. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17343986&form=6&db=m Novel therapeutic approaches in the treatment of advanced pancreatic carcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350593&form=6&db=m Lipoprotein lipase activator ameliorates the severity of dietary steatohepatitis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17352244&form=6&db=m Prognostic factors in Hungarian breast cancer patients. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17354234&form=6&db=m Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17354612&form=6&db=m Cyclooxygenase-2 (COX-2) expression in human endometrial carcinoma and precursor lesions and its possible use in cancer chemoprevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355023&form=6&db=m Cyclooxygenase-2 expression in ependymoma of the spinal cord. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17356569&form=6&db=m Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363183&form=6&db=m Antidepressants, prostaglandins and the prevention and treatment of cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363603&form=6&db=m Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17364333&form=6&db=m Expression of cyclooxygenase-2 mRNA in peripheral blood of head and neck cancer patients and in healthy controls. A pilot study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17364553&form=6&db=m Quantitative analysis of breast cancer tissue microarrays shows high cox-2 expression is associated with poor outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17365836&form=6&db=m Expression of 15-hydroxyprostaglandin dehydrogenase, a COX-2 antagonist and tumour suppressor, is not altered in gastric carcinomas. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369603&form=6&db=m Nicotine promotes colon tumor growth and angiogenesis through beta-adrenergic activation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369849&form=6&db=m Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369862&form=6&db=m Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17372274&form=6&db=m Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17376510&form=6&db=m Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17378912&form=6&db=m Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17379219&form=6&db=m Tumor markers in ovarian carcinoma. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17380299&form=6&db=m The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384033&form=6&db=m Role of NF-kappaB in TNF-alpha-induced COX-2 expression in synovial fibroblasts from human TMJ. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17384145&form=6&db=m EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17387473&form=6&db=m Immune restoration in head and neck cancer patients after in vivo COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17392171&form=6&db=m A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17395421&form=6&db=m Synergistic effects of meloxicam and conventional cytotoxic drugs in human MG-63 osteosarcoma cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17398016&form=6&db=m Macrophages from irradiated tumors express higher levels of iNOS, arginase-I and COX-2, and promote tumor growth. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17400285&form=6&db=m Overexpression of folate binding protein and mesothelin are associated with uterine serous carcinoma. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404014&form=6&db=m Apoptotic effect of celecoxib dependent upon p53 status in human ovarian cancer cells. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404023&form=6&db=m The cyclooxygenase-2 selective inhibitor celecoxib suppresses proliferation and invasiveness in the human oral squamous carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404026&form=6&db=m Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404027&form=6&db=m Increased cyclooxygenase-2 expression associated with inflammatory cellular infiltration in elderly patients with vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404058&form=6&db=m Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404063&form=6&db=m Epigallocatechin gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin: role of p38 MAPK. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404068&form=6&db=m KG-135 inhibits COX-2 expression by blocking the activation of JNK and AP-1 in phorbol ester-stimulated human breast epithelial cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404070&form=6&db=m Possible link between NO concentrations and COX-2 expression in systems treated with soy-isoflavones. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404892&form=6&db=m NSAIDs and breast cancer recurrence in a prospective cohort study. diagnostic usage,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17405913&form=6&db=m Role of proteinase-activated receptor-2 on cyclooxygenase-2 expression in H. pylori-infected gastric epithelial cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409458&form=6&db=m Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413988&form=6&db=m Identification of potential prognostic markers for vulvar cancer using immunohistochemical staining of tissue microarrays. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17415111&form=6&db=m Cyclooxygenase 2 expression in cervical intraepithelial neoplasia and vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17416236&form=6&db=m Expression of Cox-1 and Cox-2 in canine mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17417780&form=6&db=m A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17418864&form=6&db=m Cyclooxygenase-2 expression induces genomic instability in MCF10A breast epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17426256&form=6&db=m Regulation of COX-2 mediated signaling by alpha3 type IV noncollagenous domain in tumor angiogenesis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17427971&form=6&db=m Prognostic significance of cyclooxygenase-2 and DNA topoisomerase IIalpha expression in oral carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17428102&form=6&db=m Cyclo-oxygenase-2 and its inhibition in cancer: is there a role? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429393&form=6&db=m Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429597&form=6&db=m The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429629&form=6&db=m Phase-II study of dose attenuated schedule of irinotecan, capecitabine, and celecoxib in advanced colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17431384&form=6&db=m Combination of cyclooxygenase-2 inhibitor and doxorubicin increases the growth inhibition and apoptosis in human hepatocellular carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17431727&form=6&db=m Comparison of molecular markers of hypoxia and imaging with (60)Cu-ATSM in cancer of the uterine cervix. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17434257&form=6&db=m Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17434930&form=6&db=m The use of a cyclooxygenase-2 inhibitor (Nepafenac) in an ocular and metastatic animal model of uveal melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17436372&form=6&db=m Transgenic Panax ginseng inhibits the production of TNF-alpha, IL-6, and IL-8 as well as COX-2 expression in human mast cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437271&form=6&db=m Prostaglandin F(2alpha) stimulates motility and invasion in colorectal tumor cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17438113&form=6&db=m Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17440100&form=6&db=m Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17440835&form=6&db=m Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17447045&form=6&db=m Local administration of WIN 55,212-2 reduces chronic granuloma-associated angiogenesis in rat by inhibiting NF-kappaB activation. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17447067&form=6&db=m A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17448140&form=6&db=m Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17450522&form=6&db=m Synergistic antitumor effects of celecoxib with 5-fluorouracil depend on IFN-gamma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17456758&form=6&db=m Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitamins. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17460548&form=6&db=m Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17460768&form=6&db=m Interleukin-8 producing malignant fibrous histiocytoma with prolonged Fever. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17462298&form=6&db=m The risks and benefits of cyclo-oxygenase-2 inhibitors in prostate cancer: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17466103&form=6&db=m Phytochemicals and cancer. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17466901&form=6&db=m Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: two steps forward, one step back. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17467980&form=6&db=m Evidence of COX-1 and COX-2 expression in Kaposi's sarcoma tissues. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17473370&form=6&db=m Prospects of controlling breast cancer metastasis by immune intervention. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475558&form=6&db=m Natural products as a gold mine for arthritis treatment. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17475804&form=6&db=m Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17477875&form=6&db=m Phenotype and in vitro function of mature MDDC generated from cryopreserved PBMC of cancer patients are equivalent to those from healthy donors. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17479405&form=6&db=m Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17481552&form=6&db=m Differential cyclooxygenase-2 transcriptional control in proliferating versus quiescent fibroblasts. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17481556&form=6&db=m 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17481558&form=6&db=m Gene expression of isoformic enzymes in arachidonate cyclooxygenase pathway and the regulation by tumor necrosis factor alpha during life cycle of adipocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483309&form=6&db=m The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483367&form=6&db=m Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17488481&form=6&db=m Selective inhibition of prostacyclin synthase activity by rofecoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493014&form=6&db=m Role of tumour necrosis factor alpha, but not of cyclo-oxygenase-2-derived eicosanoids, on functional and morphological indices of dystrophic progression in mdx mice: a pharmacological approach. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17493439&form=6&db=m [Cyclooxygenase 2 and colorectal cancer: therapeutic implications] causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17495768&form=6&db=m Lumbar ligamentum flavum hypertrophy is due to accumulation of inflammation-related scar tissue. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17497299&form=6&db=m Expression of p63 and cyclooxygenase-2 and their correlation in skin tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17499752&form=6&db=m Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504375&form=6&db=m Cell proliferation activity unrelated to COX-2 expression in ovarian tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504996&form=6&db=m Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17505259&form=6&db=m Cyclooxygenase-2 (COX-2): first immunohistochemical marker distinguishing early cutaneous melanomas from benign melanocytic skin tumours. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17510310&form=6&db=m Silencing of cyclooxygenase-2 inhibits metastasis and delays tumor onset of poorly differentiated metastatic breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17511025&form=6&db=m Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17522398&form=6&db=m Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525632&form=6&db=m Cyclooxygenase-2 (COX-2) overexpression in meningiomas: real time PCR and immunohistochemistry. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17532073&form=6&db=m Concurrent celecoxib versus placebo in patients with stage II-III non-small cell lung cancer: a randomised phase II trial. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17535415&form=6&db=m Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanate. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17536311&form=6&db=m Expression of cyclooxygenase-2 in osteosarcoma of bone. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17538008&form=6&db=m Blockade of AT1 receptor reduces apoptosis, inflammation, and oxidative stress in normotensive rats with intracerebral hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17538120&form=6&db=m Gene expression changes in peripheral blood mononuclear cells during measles virus infection. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17540723&form=6&db=m Cox-2 promotes chromogranin A expression and bioactivity: evidence for a prostaglandin E2-dependent mechanism and the involvement of a proximal cyclic adenosine 5'-monophosphate-responsive element. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17542608&form=6&db=m Anti-inflammatory effect of alpha-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-kappaB and mitogen-activated protein kinase pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17542993&form=6&db=m COX-2 expression in lobular in situ neoplasia of the breast: correlation with histopathological grading system according to the Tavassoli classification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17544005&form=6&db=m In regard to Ishikawa et al.: Cyclooxygenase-2 impairs treatment effect of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis (Int J Radiat Oncol Biol Phys 2006;66:1347-1355). therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17545608&form=6&db=m Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17546600&form=6&db=m Improvement of hyperlipidemia by indomethacin in Min mice. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17546626&form=6&db=m The cyclooxygenase-2-mediated prostaglandin signaling is causally related to epithelial carcinogenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17548167&form=6&db=m PPAR gamma agonists can be expected to potentiate the efficacy of metronomic chemotherapy through CD36 up-regulation. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17549374&form=6&db=m VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17550381&form=6&db=m Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17553653&form=6&db=m Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17556653&form=6&db=m Interferon-gamma suppresses cyclooxygenase-2 promoter activity by inhibiting C-Jun and C/EBPbeta binding. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17569207&form=6&db=m Antioxidant and anti-inflammatory properties of curcumin. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17570326&form=6&db=m Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17571910&form=6&db=m New dosage formulations for targeted delivery of cyclo-oxygenase-2 inhibitors: focus on use in the elderly. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17572069&form=6&db=m Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17575102&form=6&db=m Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17578436&form=6&db=m Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581404&form=6&db=m Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17582597&form=6&db=m Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17582802&form=6&db=m Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, on the growth of human ovarian cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17583568&form=6&db=m The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependent. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584158&form=6&db=m Back to the future: COX-2 inhibitors for chemoprevention and cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584489&form=6&db=m Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17591056&form=6&db=m Clinicopathologic significance of expression of cyclooxygenase-2 in human esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17592230&form=6&db=m Tumor size significantly correlates with postoperative liver metastases and COX-2 expression in patients with resectable pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17593823&form=6&db=m [The growth inhibitory effect of non-steroid anti-inflammatory drugs on ovarian cancer] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17594159&form=6&db=m Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17595784&form=6&db=m Predicting the outcome of squamous cell carcinoma of the uterine cervix using combinations of individual tumor marker expressions. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17600311&form=6&db=m EGFR Signaling Is Required for TGF-beta1 Mediated COX-2 Induction in Human Bronchial Epithelial Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17603773&form=6&db=m Cyclooxygenase-2 expression in human irradiated uveal melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17604021&form=6&db=m Signal transduction pathways for epidermal growth factor stimulated cyclooxygenase-2 induction in astrocytes. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17604828&form=6&db=m Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17608853&form=6&db=m Involvement of cyclooxygenase-2 and vascular endothelial growth factor in vascularization and lymph node metastasis of colorectal cancers with submucosal invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609359&form=6&db=m Cyclooxygenase-2 immunoreactivity in equine ocular squamous-cell carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609425&form=6&db=m Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612047&form=6&db=m Cyclooxygenase-2 (cox-2) and the inflammogenesis of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612052&form=6&db=m Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17615180&form=6&db=m Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17615567&form=6&db=m Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck, and gastrointestinal tract. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17616668&form=6&db=m EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17619937&form=6&db=m COX-2 mRNA expression is significantly increased in acid-exposed compared to nonexposed squamous epithelium in gastroesophageal reflux disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624083&form=6&db=m Expression of gelatinase (MMP-2 and MMP-9) and cyclooxygenase-2 (COX-2) in endometrial carcinoma. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17624243&form=6&db=m Cyclooxygenase isozymes in oral squamous cell carcinoma:a real-time RT-PCR study with clinic pathological correlations. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17629053&form=6&db=m Cyclooxygenase-2 expression in gastroenteropancreatic neuroendocrine tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17630920&form=6&db=m Nicotine, lung and cancer. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17635918&form=6&db=m Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640307&form=6&db=m Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640394&form=6&db=m Inflammation and breast cancer. Cyclooxygenase/prostaglandin signaling and breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17640750&form=6&db=m Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645771&form=6&db=m Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid hormone-related protein in colon 26 carcinoma. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645803&form=6&db=m Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652141&form=6&db=m Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652651&form=6&db=m Rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652824&form=6&db=m Anti-inflammatory and side effects of cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17653443&form=6&db=m Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17660403&form=6&db=m Mapping of the proinflammatory domains of MspTL of Treponema lecithinolyticum. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17661725&form=6&db=m A retrospective analysis of cardiovascular morbidity in metastatic hormone-refractory prostate cancer patients on high doses of the selective COX-2 inhibitor celecoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17662711&form=6&db=m Anti-inflammatory activity of 21(alpha, beta)-methylmelianodiols, novel compounds from Poncirus trifoliata Rafinesque. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17666052&form=6&db=m High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17667525&form=6&db=m Rofecoxib has different effects on chemokine production in colorectal cancer cells and tumor immune splenocytes. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17668425&form=6&db=m Targeting cell signaling pathways for drug discovery: an old lock needs a new key. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671709&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor in primary central nervous system lymphomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17672932&form=6&db=m [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17687192&form=6&db=m Prognostic significance of vascular endothelial growth factor and cyclooxygenase-2 in patients with rectal cancer treated with preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17689613&form=6&db=m Copper conjugates of nimesulide Schiff bases targeting VEGF, COX and Bcl-2 in pancreatic cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17691904&form=6&db=m Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17691907&form=6&db=m Inducible nitric oxide synthase-vascular endothelial growth factor axis: a potential target to inhibit tumor angiogenesis by dietary agents. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17695086&form=6&db=m In vitro study of biofunctional indicators after exposure to asbestos-like fluoro-edenite fibres. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17695530&form=6&db=m Anticancer effects of licofelone (ML-3000) in prostate cancer cells. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17695552&form=6&db=m Celecoxib increased expression of 14-3-3sigma and induced apoptosis of glioma cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17696261&form=6&db=m Ectopic hepatocellular carcinoma arising from pancreas: a case report and review of the literature. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17697546&form=6&db=m [Correlation of cyclooxygenase-2 expression to P-glycoprotein expression in B-cell non-Hodgkin's lymphoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17697767&form=6&db=m Ciglitazone mediates COX-2 dependent suppression of PGE2 in human non-small cell lung cancer cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17699852&form=6&db=m OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17700013&form=6&db=m An evaluation of cyclooxygenase-2 as a prognostic biomarker in mid-gut carcinoid tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17704356&form=6&db=m Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-{alpha} in the Rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17707579&form=6&db=m Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17708250&form=6&db=m Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17708399&form=6&db=m Regulation of COX-2 expression in canine prostate carcinoma: increased COX-2 expression is not related to inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17710160&form=6&db=m Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17711445&form=6&db=m Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17716351&form=6&db=m Therapeutic effect of nimesulide on colorectal carcinogenesis in experimental murine ulcerative colitis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17719233&form=6&db=m Effects of celecoxib on voltage-gated calcium channel currents in rat pheochromocytoma (PC12) cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17721268&form=6&db=m COX-2 expression in invasive breast cancer: correlation with prognostic parameters and outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17723174&form=6&db=m Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17725981&form=6&db=m The effect of meloxicam, a selective COX-2 inhibitor, on the microvasculature of small metastatic liver tumors in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17727827&form=6&db=m Activation of microglial cells by ceruloplasmin. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17760822&form=6&db=m Cyclosporin-A inhibits the expression of cyclooxygenase-2 in gingiva. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17762961&form=6&db=m 5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17763971&form=6&db=m Cyclooxygenases, prostanoids, and tumor progression. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17767717&form=6&db=m The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17767925&form=6&db=m Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-kappaB activation and COX-2 expression in human breast epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785115&form=6&db=m [The potential role of Id1 in COX-2 mediated angiogenesis in gastric cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785554&form=6&db=m Cyclooxygenase-2 and platelet-derived growth factor receptors as potential targets in treating aggressive fibromatosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17786343&form=6&db=m Peroxisome proliferator-activated receptor alpha and gamma ligands inhibit the growth of human ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17826515&form=6&db=m Successful preoperative treatment of pediatric bladder inflammatory myofibroblastic tumor with anti-inflammatory therapy. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17826825&form=6&db=m COX-2 overexpression as a biomarker of early cervical carcinogenesis: A pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17828511&form=6&db=m The expression of cyclooxygenase-2 in cervical cancers and Hela cells was regulated by estrogen/progestogen. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17845860&form=6&db=m Avocado soybean unsaponifiables (ASU) suppress TNF-alpha, IL-1beta, COX-2, iNOS gene expression, and prostaglandin E2 and nitric oxide production in articular chondrocytes and monocyte/macrophages. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17846040&form=6&db=m Correlations between cyclooxygenase-2 expression and angiogenic factors in primary tumors and liver metastases in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17848290&form=6&db=m Integrating surgery into treatment paradigms for organ preservation: tailoring treatment to biology improves outcomes. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17851687&form=6&db=m COX-2 localization within plasma membrane caveolae-like structures in human lobular intraepithelial neoplasia of the breast. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855475&form=6&db=m Neuroprotective effects of glyceryl nonivamide against microglia-like cells and 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y human dopaminergic neuroblastoma cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868457&form=6&db=m Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868774&form=6&db=m Clinical significance of prostaglandin E synthase expression in gastric cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17869184&form=6&db=m COX-2 expression in B lymphocytes: Links to vaccines, inflammation and malignancy. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875728&form=6&db=m Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17881290&form=6&db=m COX-2 expression predicts prostate-cancer outcome: analysis of data from the RTOG 92-02 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17882652&form=6&db=m Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17888030&form=6&db=m Potent inhibition of in vivo angiogenesis and tumor growth by a novel cyclooxygenase-2 inhibitor, enoic acanthoic acid. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17888194&form=6&db=m Expression of cyclooxygenase-2, vascular endothelial growth factor and matrix metalloproteinase-2 in patients with primary laryngeal carcinoma: a tissue microarray study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17889918&form=6&db=m Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893235&form=6&db=m Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17893865&form=6&db=m Targeting NOX, INOS and COX-2 in inflammatory cells: Chemoprevention using food phytochemicals. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17897185&form=6&db=m A comparative study of the preventative effects exerted by three probiotics, Bifidobacterium lactis, Lactobacillus casei and Lactobacillus acidophilus, in the TNBS model of rat colitis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17906315&form=6&db=m Arsenic salt-induced DNA damage and expression of mutant p53 and COX-2 proteins in SV-40 immortalized human uroepithelial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17906615&form=6&db=m Prostanoid receptor EP1 expression in breast cancer. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908963&form=6&db=m Comparative Analysis of Peritoneum and Tumor Eicosanoids and Pathways in Advanced Ovarian Cancer. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908994&form=6&db=m Exisulind in Combination with Celecoxib Modulates Epidermal Growth Factor Receptor, Cyclooxygenase-2, and Cyclin D1 against Prostate Carcinogenesis: In vivo Evidence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909024&form=6&db=m An increased expression of cysteinyl leukotriene 2 receptor in colorectal adenocarcinomas correlates with high differentiation. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909047&form=6&db=m Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909831&form=6&db=m Glottic versus supraglottic tumors: differential molecular profile. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17914586&form=6&db=m Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17916073&form=6&db=m Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy: evidence for a Bcl-2-dependent mechanism. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17917259&form=6&db=m Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919838&form=6&db=m Cyclooxygenase-2 expression as a predictor of para-aortic lymph node recurrence in uterine cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17921715&form=6&db=m COX-2 and NF-KB overexpression is common in pancreatic cancer but does not predict for COX-2 inhibitors activity in combination with gemcitabine and oxaliplatin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928716&form=6&db=m Cytokine responses of intestinal epithelial-like caco-2 cells to non-pathogenic and opportunistic pathogenic yeasts in the presence of butyric Acid. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17928958&form=6&db=m Surfactin C inhibits Mycoplasma hyopneumoniae-induced transcription of proinflammatory cytokines and nitric oxide production in murine RAW 264.7 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934334&form=6&db=m Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934641&form=6&db=m Over-expression of cyclooxygenase-2 in endoscopic biopsies of ectopic gastric mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17936723&form=6&db=m Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian cancer and colon cancer is independent of COX-2 expression levels. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17938261&form=6&db=m IB05204, a dichloropyridodithienotriazine, inhibits angiogenesis in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17939563&form=6&db=m In vitro cyclooxygenase-2 protein expression and enzymatic activity in neoplastic cells. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17942462&form=6&db=m The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17943250&form=6&db=m Influence of simultaneous inhibition of cyclooxygenase-2 and inducible nitric oxide synthase in experimental colitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17944529&form=6&db=m Myricetin down-regulates phorbol ester-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking activation of nuclear factor kappa B. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17948911&form=6&db=m Response to dual blockade of epidermal growth factor receptor (EGFR) and cycloxygenase-2 in nonsmall cell lung cancer may be dependent on the EGFR mutational status of the tumor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17950089&form=6&db=m Effect of Celecoxib and Novel Agent LC-1 in a Hamster Model of Lung Cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17952743&form=6&db=m Expression of Cyclooxygenase-2 and Its Correlation with Vasogenic Brain Edema in Human Intracranial Meningiomas. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17955050&form=6&db=m Cyclooxygenase-2 overexpression abrogates the antiproliferative effects of TGF-beta. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17961045&form=6&db=m Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962194&form=6&db=m Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17962941&form=6&db=m Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963953&form=6&db=m Proinflammatory Cytokine Expression in Cyclooxygenase-2-deficient Primary Osteoblasts. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17966896&form=6&db=m [Non-steroidal anti-inflammatory drugs and intestinal side effects] unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17968315&form=6&db=m Celecoxib and a novel COX-2 inhibitor ON09310 upregulate death receptor 5 expression via GADD153/CHOP. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17968676&form=6&db=m PTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17970040&form=6&db=m Cyclooxygenase-2 expression correlates with apoptosis and angiogenesis in endometrial cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971584&form=6&db=m Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971769&form=6&db=m COX-2 inhibitor celecoxib prevents chronic morphine-induced promotion of angiogenesis, tumour growth, metastasis and mortality, without compromising analgesia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974958&form=6&db=m Inhibition of Cyclooxygenase-2 Suppresses Lymph Node Metastasis via Reduction of Lymphangiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17975975&form=6&db=m Early laminar events involving endothelial activation in horses with black walnut- induced laminitis. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17977562&form=6&db=m Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17982644&form=6&db=m Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17985342&form=6&db=m Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17993511&form=6&db=m Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996232&form=6&db=m Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996386&form=6&db=m Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996482&form=6&db=m Expression of cyclooxygenase-2 and DNA topoisomerase II alpha in precancerous and cancerous lesions of the oral mucosa. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17998819&form=6&db=m CD44 and PTGS2 methylation are independent prognostic markers for biochemical recurrence among prostate cancer patients with clinically localized disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17999989&form=6&db=m Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18000398&form=6&db=m Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18003891&form=6&db=m Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18006811&form=6&db=m Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18019697&form=6&db=m The role of NSAIDs in colon cancer prevention. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18027868&form=6&db=m CS-706, a novel cyclooxygenase-2 selective inhibitor, prolonged the survival of tumor-bearing mice when treated alone or in combination with anti-tumor chemotherapeutic agents. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18030357&form=6&db=m Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18038902&form=6&db=m Inhibition of inducible prostaglandin E2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18042295&form=6&db=m The effects of a cyclooxygenase-2 (COX-2) expression and inhibition on human uveal melanoma cell proliferation and macrophage nitric oxide production. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045183&form=6&db=m Cyclooxygenase-2 (COX-2)--a therapeutic target in liver cancer? causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18050111&form=6&db=m Cyclooxygenase-2 expression in primary and recurrent pterygium. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18053191&form=6&db=m Bortezomib in combination with celecoxib in patients with advanced solid tumors: a phase I trial. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055324&form=6&db=m Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055759&form=6&db=m Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18057724&form=6&db=m Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-kappaB inactivation in RAW 264.7 macrophage cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058473&form=6&db=m Interaction of cigarette smoking with cyclooxygenase-2 on ulcerative colitis-associated neoplasia in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058808&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase suppresses K-RasV12-dependent tumor formation in Nu/Nu mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18058818&form=6&db=m The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18059022&form=6&db=m 4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18059327&form=6&db=m Effects of zileuton and montelukast in mouse experimental spinal cord injury. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18061524&form=6&db=m Overexpression of COX-2 and LMP1 are correlated with lymph node in Tunisian NPC patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18062281&form=6&db=m [The expression and significance of HIF-1alpha and COX-2 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18064740&form=6&db=m CD44 and PTGS2 methylation are independent prognostic markers for biochemical recurrence among prostate cancer patients with clinically localized disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18067784&form=6&db=m In vitro anti-inflammatory effects of different solution fractions of ethanol extract from Melilotus suaveolens Ledeb. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18068001&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor-C correlates with lymphangiogenesis and lymphatic invasion in human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18069634&form=6&db=m [Expression of COX-2 and MMP-9 in cervical carcinoma and their clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071320&form=6&db=m Decisive role of cyclooxygenase-2 and lipocalin-type prostaglandin D synthase in chemotherapeutics-induced apoptosis of human cervical carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18071704&form=6&db=m Impact of celecoxib on capecitabine tolerability and activity in pretreated metastatic breast cancer: results of a phase II study with biomarker evaluation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18076062&form=6&db=m Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18078766&form=6&db=m Celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18087221&form=6&db=m Coix Seed Extract, a Commonly Used Treatment for Cancer in China, Inhibits NFkappaB and Protein Kinase C Signaling. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18089846&form=6&db=m The effects of cyclooxygenase-2 expression in prostate cancer cells: modulation of response to cytotoxic agents. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18092051&form=6&db=m Expression of cyclooxygenase-2 and transforming growth factor-beta1 in HCV-induced chronic liver disease and hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094611&form=6&db=m Increased expression of cytoplasmic HuR in familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18095161&form=6&db=m Glucocorticoid availability in colonic inflammation of rat. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18095163&form=6&db=m Synergistic regulation of COX-2 expression by bombesin and transforming growth factor-beta. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159171&form=6&db=m [COX-2 inhibitors in inflammatory bowel disease: friends or foes?] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18159174&form=6&db=m [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18164040&form=6&db=m Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study. diagnostic usage,therapeutic application,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18172254&form=6&db=m Prognostic significance of cyclooxygenase-2 overexpression in glottic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173552&form=6&db=m Strong evidence for up-regulation of cyclooxygenase-1 in head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174234&form=6&db=m Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18176605&form=6&db=m Role of Toll-like receptors in gastrointestinal malignancies. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18181047&form=6&db=m Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18181832&form=6&db=m Cyclooxygenase-2 (Cox-2) expression and angiogenesis in glioblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18186150&form=6&db=m COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18187276&form=6&db=m COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18190720&form=6&db=m Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18190825&form=6&db=m Tissue microarray based analysis of prognostic markers in invasive bladder cancer: much effort to no avail? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18192694&form=6&db=m 15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194346&form=6&db=m Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18197933&form=6&db=m COX-2 mRNA expression in esophageal squamous cell carcinoma (ESCC) and effect by NSAID. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18198830&form=6&db=m Pectin does not inhibit intestinal carcinogenesis in APC-deficient Min/+ mice. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199541&form=6&db=m Cyclooxygenase-2 expression during immortalization and breast cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18201240&form=6&db=m Cyclooxygenase-2 expression in dermatofibroma and dermatofibrosarcoma protuberans. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202307&form=6&db=m Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202786&form=6&db=m Inhibitory effects of the cyclooxygenase-2 inhibitor, etodolac, on colitis-associated tumorigenesis in p53-deficient mice treated with dextran sulfate sodium. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202806&form=6&db=m Antiproliferative and proapoptotic effects of rapamycin and celecoxib in malignant melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18204294&form=6&db=m Correlative expression of cyclooxygenase-1 (cox-1) and human epidermal growth factor receptor type-2 (her-2) in endometrial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18207033&form=6&db=m Interplay between oncoproteins and antioxidant enzymes in esophageal carcinoma treated without and with chemoradiotherapy: a prospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18214062&form=6&db=m hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18214064&form=6&db=m Evaluation of the prognostic role of a panel of biomarkers in stage IB-IIIA non-small cell lung cancer patients. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18214991&form=6&db=m Ciliary neurotrophic factor and interleukin-6 differentially activate microglia. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18216296&form=6&db=m Modulation of angiogenesis by omega-3 polyunsaturated fatty acids is mediated by cyclooxygenases. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220987&form=6&db=m Current status of COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18222600&form=6&db=m Celecoxib has potent antitumour effects as a single agent and in combination with BCG immunotherapy in a model of urothelial cell carcinoma. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230053&form=6&db=m Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230181&form=6&db=m Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18240541&form=6&db=m Convergence of genetic, nutritional and inflammatory factors in gastrointestinal cancers. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18242386&form=6&db=m Etodolac, a selective cyclooxygenase-2 inhibitor, induces upregulation of E-cadherin and has antitumor effect on human bladder cancer cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18247029&form=6&db=m Celecoxib inhibits growth of tumors in a syngeneic rat liver metastases model for colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18250037&form=6&db=m [Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18256803&form=6&db=m Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18259945&form=6&db=m Metastasis-associated protein S100A4 and p53 predict relapse in curatively resected stage III and IV (M0) gastric cancer. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18262365&form=6&db=m Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18262731&form=6&db=m Estrogen-dependent prognostic significance of cyclooxygenase-2 expression in early-stage invasive breast cancers treated with breast-conserving surgery and radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18266820&form=6&db=m Protective effects of cyclooxygenase-2 inhibitors on narrow-band ultraviolet B-irradiated epidermal Ia+ Langerhans cells and Thy-1+ dendritic epidermal T cells in mice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18266822&form=6&db=m Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18275990&form=6&db=m Cyclooxygenase-2 in cervical neoplasia: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18281498&form=6&db=m Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18284542&form=6&db=m A study of phosphorylated ERK1/2 and COX-2 in early stage (T1-T2) oral squamous cell carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18287342&form=6&db=m Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288396&form=6&db=m Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18289124&form=6&db=m Compositions for treatment of cancer and inflammation. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18289174&form=6&db=m Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18293189&form=6&db=m Expression of COX-2 and prognostic outcome in uveal melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18297687&form=6&db=m Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18299817&form=6&db=m Novel modulatory effects of SDZ 62-434 on inflammatory events in activated macrophage-like and monocytic cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18307280&form=6&db=m Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18310926&form=6&db=m The flavouring phytochemical 2-pentanone reduces prostaglandin production and COX-2 expression in colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18311113&form=6&db=m The COX-2 promoter polymorphism -765 G>C is associated with early-onset, conventional and stump gastric cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18312384&form=6&db=m Passive cigarette smoke exposure inhibits ultraviolet light B-induced skin tumors in SKH-1 hairless mice by blocking the nuclear factor kappa B signalling pathway. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18313400&form=6&db=m Modulation of inflammatory responses by diterpene acids from Helianthus annuus L. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314621&form=6&db=m [NF-kappaB subunit p65/RelA expression in ovarian carcinoma: prognostic impact and link to COX-2 overexpression] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314623&form=6&db=m [Significance of cyclooxygenase-2 as a chemotherapeutic target in hepatocellular carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18316610&form=6&db=m Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18319253&form=6&db=m Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18320325&form=6&db=m The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18320840&form=6&db=m Role of cyclooxygenase-2 in tumor progression and immune regulation in lung cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18323852&form=6&db=m Expression-targeted gene therapy for the treatment of transitional cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18325594&form=6&db=m Pattern of expression of immune-relevant genes in the gonad of a teleost, the gilthead seabream (Sparus aurata L.). unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18328446&form=6&db=m A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglial cells: Implication for a potential anti-inflammatory effect. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18329172&form=6&db=m Lipopolysaccharide activates the kallikrein-kinin system in mouse choroid plexus cell line ECPC4. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18330256&form=6&db=m [Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18334709&form=6&db=m Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18335236&form=6&db=m Acetylsalicylic acid induces programmed cell death in Arabidopsis cell cultures. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18336314&form=6&db=m Carbonic anhydrase inhibition: insight into non-COX-2 pharmacological effect of some coxibs. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18338835&form=6&db=m The cyclo-oxygenase 2 promoter is induced in nontarget cells following adenovirus infection, but an AU-rich 3'-untranslated region destabilization element can increase specificity. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18341647&form=6&db=m A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18344086&form=6&db=m [Protein expression and clinical significance of cyclooxygenase 2 and nuclear factor kappa B in gastric mucosa-associated lymphoid tissue lymphoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18345025&form=6&db=m Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18346877&form=6&db=m Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18348265&form=6&db=m Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18348652&form=6&db=m NS-398 enhances the efficacy of gemcitabine against lung adenocarcinoma through up-regulation of p21WAF1 and p27KIP1 protein. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18349286&form=6&db=m Comparative Bioavailability of Sulindac in Capsule and Tablet Formulations. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18349821&form=6&db=m Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18353210&form=6&db=m [The relationship between lymphatic metastasis and serum vascular endothelial growth factor C and cyclooxygenase 2 expression in breast cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18356024&form=6&db=m Overexpression of COX-2 gene in oral cancer is independent of stage of disease and degree of differentiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18357839&form=6&db=m Inflammatory factor profiles one hour following vocal fold injury. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18360718&form=6&db=m Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18362501&form=6&db=m Cyclooxygenase-2 expression in human thyroid disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367112&form=6&db=m Forced COX-2 expression induces PGE(2) and invasion in immortalized urothelial cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367515&form=6&db=m Pro-labour myometrial gene expression: are preterm labour and term labour the same? therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18373164&form=6&db=m Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18373616&form=6&db=m Diabetes, colorectal cancer and cyclooxygenase 2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18380483&form=6&db=m Synthesis and biological evaluation of novel sulfonanilide compounds as antiproliferative agents for breast cancer. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381589&form=6&db=m Resveratrol directly targets COX-2 to inhibit carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381949&form=6&db=m The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18383135&form=6&db=m Role of the tumor necrosis factor-alpha, cyclooxygenase-2, prostaglandin E2, and effect of low-intensity pulsed ultrasound in an in vitro herniated disc resorption model. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18384098&form=6&db=m Multi-targeted therapy by curcumin: how spicy is it? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18384626&form=6&db=m The relationship between the local and systemic inflammatory responses and survival in patients undergoing resection for localized renal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18389516&form=6&db=m Thalidomide as a multi-template for development of biologically active compounds. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18392637&form=6&db=m The role of COX-2 in rectal cancer treated with preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18393858&form=6&db=m Non-steroidal targets in the diagnosis and treatment of endometriosis. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18397190&form=6&db=m Expression of genes in the canine pre-implantation uterus and embryo: implications for an active role of the embryo before and during invasion. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18398660&form=6&db=m Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18400268&form=6&db=m Correlation of COX-2 expression in stromal cells with high stage, high grade, and poor prognosis in urothelial carcinoma of upper urinary tracts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18408893&form=6&db=m Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cells. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413658&form=6&db=m Molecular mechanisms of topical anti-inflammatory effects of lipoxin A(4) in endotoxin-induced uveitis. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18416056&form=6&db=m [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)] causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18417710&form=6&db=m Identification of potential markers of oocyte competence expressed in bovine cumulus cells matured with follicle-stimulating hormone and/or phorbol myristate acetate in vitro. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18423123&form=6&db=m [Synergistic lethal effect of mDRA-6 and nimesulide on human hepatocellular cancer cell line SMMC-7721] ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18429007&form=6&db=m Basic evidence of molecular targeted therapy for oral cancer and salivary gland cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18432307&form=6&db=m The effect of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-6 on chorioamnion secretion of prostaglandins (PG)F 2 alpha and E2 in pigs. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18436450&form=6&db=m Pancreatic cancer: from molecular signature to target therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437654&form=6&db=m Association of tumor necrosis factor, interleukin-6 and cyclooxygenase pathway with lipopolysaccharide-induced intussusception. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438340&form=6&db=m Celecoxib inhibits tumor growth and angiogenesis in an orthotopic implantation tumor model of human colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18443952&form=6&db=m Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18444174&form=6&db=m Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446786&form=6&db=m Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18449376&form=6&db=m Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18451151&form=6&db=m Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18459994&form=6&db=m Overexpression of cyclooxygenase-2 is associated with chemoradiotherapy resistance and prognosis in esophageal squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462890&form=6&db=m Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18466392&form=6&db=m The effects of cyclooxygenase2-prostaglandinE2 pathway on Helicobacter pylori-induced urokinase-type plasminogen activator system in the gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468781&form=6&db=m Overexpression of ELAV-like Protein HuR is Associated with Increased COX-2 Expression in Atrophy, High-grade Prostatic Intraepithelial Neoplasia, and Incidental Prostate Cancer in Cystoprostatectomies. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18469157&form=6&db=m Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18473929&form=6&db=m Mechanism of action of key enzymes associated with cancer propagation and their inhibition by various chemotherapeutic agents. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18477580&form=6&db=m COX-2 targeting in cancer: a new beginning? therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18479787&form=6&db=m Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18480072&form=6&db=m 17-Beta estradiol and hydroxyestradiols interact via the NF-kappa B pathway to elevate cyclooxygenase 2 expression and prostaglandin E2 secretion in human bronchial epithelial cells. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18481333&form=6&db=m Selenium attenuates pro-inflammatory gene expression in macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18482003&form=6&db=m Complexity of COX-2 gene regulation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18483177&form=6&db=m Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18485224&form=6&db=m COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18485806&form=6&db=m Inflammation: gearing the journey to cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18488158&form=6&db=m Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18496814&form=6&db=m Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18498063&form=6&db=m Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus). causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18499296&form=6&db=m A phase II study of carboplatin and paclitacel with meloxicam. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18505747&form=6&db=m Cyclooxygenase-2 in Cancer and Angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18509181&form=6&db=m Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18509974&form=6&db=m [The effect of cyclooxygenase-2 on lymphangiogenesis in breast cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18511850&form=6&db=m Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18513703&form=6&db=m CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18519570&form=6&db=m Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18521687&form=6&db=m Lactate dehydrogenase-5 (LDH-5) expression in human gastric cancer: association with hypoxia-inducible factor (HIF-1alpha) pathway, angiogenic factors production and poor prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18522674&form=6&db=m Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-treated rats. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18524942&form=6&db=m Depletion of cellular cholesterol enhances macrophage MAPK activation by chitin microparticles but not by heat-killed Mycobacterium bovis BCG. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18534745&form=6&db=m RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of HeLa cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537861&form=6&db=m Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma during malignant melanoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18551458&form=6&db=m Pterostilbene is equally potent as resveratrol in inhibiting 12-O-tetradecanoylphorbol-13-acetate activated NFkappaB, AP-1, COX-2, and iNOS in mouse epidermis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18555844&form=6&db=m Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559496&form=6&db=m Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18559542&form=6&db=m Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18566751&form=6&db=m Inhibitory effect of 30-kDa phytoglycoprotein on expression of TNF-alpha and COX-2 via activation of PKCalpha and ERK 1/2 in LPS-stimulated RAW 264.7 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18567620&form=6&db=m Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571585&form=6&db=m Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577844&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses the growth of pancreatic cancer cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18591367&form=6&db=m Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18592138&form=6&db=m shRNA-targeted Cyclooxygenase (COX)-2 inhibits proliferation, reduces invasion and enhances chemosensitivity in laryngeal carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18593902&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18594470&form=6&db=m Cyclooxygenase-2 expression in primary and metastatic Merkel cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18596194&form=6&db=m Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18613363&form=6&db=m Correlation between expression of cyclooxygenase-2 and the presence of CD4+ infiltrating T-lymphocyte in human primary hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18613795&form=6&db=m Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617357&form=6&db=m In vitro and in vivo inhibitory effect evaluation of cyclooxygenase-2 inhibitors, antisense cyclooxygenase-2 cDNA, and their combination on the growth of human bladder cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617777&form=6&db=m Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18618313&form=6&db=m Lactobacillus acidophilus 74-2 and butyrate induce cyclooxygenase (COX)-1 expression in gastric cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18619641&form=6&db=m COX-2 gene polymorphisms and protein expression in renomedullary interstitial cell tumors. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632220&form=6&db=m COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632614&form=6&db=m Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18633528&form=6&db=m 2, 3-Diaryl-5-ethylsulfanylmethyltetrahydrofurans as a new class of COX-2 inhibitors and cytotoxic agents. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18634847&form=6&db=m TRAIL-mediated apoptosis in malignant glioma cells is augmented by celecoxib through proteasomal degradation of survivin. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18636311&form=6&db=m Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18642283&form=6&db=m Prostaglandin E(2) pathway in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18648368&form=6&db=m Prostaglandin E2 stimulates Fas ligand expression via the EP1 receptor in colon cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18650097&form=6&db=m Synthesis and evaluation in vitro and in vivo of a 11C-labeled cyclooxygenase-2 (COX-2) inhibitor. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18653328&form=6&db=m Celecoxib pre-treatment in human colorectal adenocarcinoma patients is associated with gene expression alterations suggestive of diminished cellular proliferation. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18657551&form=6&db=m Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18663571&form=6&db=m Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18664561&form=6&db=m Preoperative radiochemotherapy is successful also in patients with locally advanced rectal cancer who have intrinsically high apoptotic tumours. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18665070&form=6&db=m Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18667313&form=6&db=m New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18670614&form=6&db=m Role of peroxisome proliferator-activated receptor alpha in the control of cyclooxygenase 2 and vascular endothelial growth factor: involvement in tumor growth. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18671849&form=6&db=m Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18674502&form=6&db=m [Genetic abnormalities of digestive tract adenocarcinomas and correlation with the histologic sequence of their development] causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18674950&form=6&db=m Actinic cheilitis: Epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676022&form=6&db=m Isoflavone-rich extracts from wooly glycine Glycine tomentella inhibits LPS-induced TNF-alpha expression in a macrophage cell line of Atlantic salmon (Salmo salar L.). ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676768&form=6&db=m Suppression of tumor formation by a cyclooxygenase-2 inhibitor and a peroxisome proliferator-activated receptor gamma agonist in an in vivo mouse model of spontaneous breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676844&form=6&db=m RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18683800&form=6&db=m [The effect of siRNA on inhibiting cyclooxygenase-2 gene expression in gastric adenocarcinoma cell] causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18684886&form=6&db=m Calcium-sensing receptor signaling pathways in medullary thick ascending limb cells mediate COX-2-derived PGE2 production: functional significance. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691115&form=6&db=m Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695912&form=6&db=m Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695918&form=6&db=m In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18700688&form=6&db=m Genetic and microenvironmental implications in prostate cancer progression and metastasis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18703638&form=6&db=m Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18705402&form=6&db=m Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18708371&form=6&db=m Cyclooxygenase-2 inhibitors in colorectal cancer prevention: point. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18711209&form=6&db=m The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18712978&form=6&db=m Lack of influence of cyclooxygenese-2 expression in hepatocellular carcinomas on patient survival. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18713982&form=6&db=m MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18720000&form=6&db=m The Simultaneous Expression of Peroxisome Proliferator-Activated Receptor Delta and Cyclooxygenase-2 May Enhance Angiogenesis and Tumor Venous Invasion in Tissues of Colorectal Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18721668&form=6&db=m Synergistic anti-hyperalgesia of electroacupuncture and low dose of celecoxib in monoarthritic rats: involvement of the cyclooxygenase activity in the spinal cord. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18722366&form=6&db=m Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18722373&form=6&db=m E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18722548&form=6&db=m Expression of Ca(2+)-independent and Ca(2+)-dependent phospholipases A(2) and cyclooxygenases in human melanocytes and malignant melanoma cell lines. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18725385&form=6&db=m Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18727644&form=6&db=m Differential effects of corticosteroids on the expression of cyclooxygenase-2, tumour necrosis factor-alpha and matrix metalloproteinase-9 in an animal model of migraine. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18751438&form=6&db=m Microvessel density (MVD) and cyclooxygenase-2 (COX-2)/ beta-catenin interaction are associated with relapse in patients with transitional carcinoma receiving adjuvant chemotherapy with paclitaxel/carboplatin: a hellenic cooperative oncology group (HECOG) study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18751910&form=6&db=m Modulation of inflammatory cytokines by omega-3 Fatty acids. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18752906&form=6&db=m Analysis of Cox-2 expression in Wilms' tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18754859&form=6&db=m Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18757412&form=6&db=m Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758376&form=6&db=m The clinical significance of coexpression of cyclooxygenases-2, vascular endothelial growth factors, and epidermal growth factor receptor in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758643&form=6&db=m Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18769553&form=6&db=m The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18788629&form=6&db=m [Biological effect of endostatin on transplanted human lung adenocarcinoma Calu-6 tumor in nude mice] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18789941&form=6&db=m Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18790560&form=6&db=m Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18790761&form=6&db=m Soluble EP2 neutralizes prostaglandin E2-induced cell signaling and inhibits osteolytic tumor growth. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18792778&form=6&db=m Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794140&form=6&db=m Prevention of both direct and cross-priming of antitumor CD8+ T-cell responses following overproduction of prostaglandin E2 by tumor cells in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18795070&form=6&db=m Tpl-2/cot and cox-2 in breast cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18797196&form=6&db=m COX-2 expression correlates with survival in patients with osteosarcoma lung metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18805045&form=6&db=m Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18805435&form=6&db=m Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18812628&form=6&db=m Tryptophan free diet delays healing of chronic gastric ulcers in rat. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18814280&form=6&db=m Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18819100&form=6&db=m Inflammatory processes of prostate tissue microenvironment drive rat prostate carcinogenesis: preventive effects of celecoxib. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18823436&form=6&db=m Anti-gastric cancer effects of celecoxib, a selective COX-2 inhibitor, through inhibition of Akt signaling. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18829529&form=6&db=m Prostaglandin E2 regulates tumor angiogenesis in prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18830381&form=6&db=m Reversibility of Aberrant Global DNA and Estrogen Receptor-alpha Gene Methylation Distinguishes Colorectal Precancer from Cancer. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18831511&form=6&db=m Expression of the embryonic lethal abnormal vision-like protein HuR in human mesothelioma: association with cyclooxygenase-2 and prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18834948&form=6&db=m Regulation of the prostaglandin pathway during development of invasive bladder cancer in mice. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18840457&form=6&db=m o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18840784&form=6&db=m Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18841446&form=6&db=m Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18841789&form=6&db=m [Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18842581&form=6&db=m Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18843292&form=6&db=m Tumor-Associated Macrophage-Induced Invasion and Angiogenesis of Human Basal Cell Carcinoma Cells by Cyclooxygenase-2 Induction. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18848748&form=6&db=m Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-kappaB and C/EBP as potential targets. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18848762&form=6&db=m ZPDC glycoprotein inhibits inflammation-related cytokine and protein via nuclear factor-kappa B in dextran sulfate sodium-stimulated ICR mouse. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18926952&form=6&db=m Anti-metastatic Action of Non-steroidal Anti-inflammatory Drugs. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18927599&form=6&db=m Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18936204&form=6&db=m Rosmarinic Acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18936210&form=6&db=m Tocotrienol Inhibits Secretion of Angiogenic Factors from Human Colorectal Adenocarcinoma Cells by Suppressing Hypoxia-Inducible Factor-1{alpha} causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18948273&form=6&db=m Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18951002&form=6&db=m Basic mechanisms behind the effects of n-3 fatty acids on cardiovascular disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18952595&form=6&db=m Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18953425&form=6&db=m The malignant phenotype of breast cancer cells is reduced by COX-2 silencing. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955286&form=6&db=m Inhibitory Potencies of Several Iridoids on Cyclooxygenase-1, Cyclooxygnase-2 Enzymes Activities, Tumor Necrosis factor-{alpha} and Nitric Oxide Production In Vitro. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18955820&form=6&db=m Antiinflammatory effect of lactic acid bacteria: inhibition of cyclooxygenase-2 by suppressing nuclear factor-kappaB in Raw264.7 macrophage cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18974063&form=6&db=m COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18976171&form=6&db=m Effect of a nonprotein bioactive agent on the reduction of cyclooxygenase-2 and tumor necrosis factor-alpha in human intervertebral disc cells in vitro. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18977022&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the uterine cervix is associated with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18980437&form=6&db=m Uterine involution and endometrial function in postpartum pony mares. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18984785&form=6&db=m Cyclooxygenase-2 expression in equine tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18985541&form=6&db=m Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18989991&form=6&db=m New approaches to the treatment of inflammatory disease : focus on small-molecule inhibitors of signal transduction pathways. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18996678&form=6&db=m Inhibition of MAP kinases and down regulation of TNF-alpha, IL-beta and COX-2 genes by the crude extracts from marine bacteria. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18997734&form=6&db=m Classification using hierarchical clustering of tumor-infiltrating immune cells identifies poor prognostic ovarian cancers with high levels of COX expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19000324&form=6&db=m Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19003584&form=6&db=m Prevention and treatment of pancreatic cancer by curcumin in combination with omega-3 fatty acids. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19003585&form=6&db=m Chemopreventive effects of the standardized extract (DA-9601) of Artemisia asiatica on azoxymethane-initiated and dextran sulfate sodium-promoted mouse colon carcinogenesis. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19004945&form=6&db=m African swine fever virus blocks the host cell antiviral inflammatory response through a direct inhibition of PKC-theta-mediated p300 transactivation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19005184&form=6&db=m Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19013259&form=6&db=m Modeling using baseline characteristics in a small multicenter clinical trial for Barrett's esophagus. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015468&form=6&db=m Cyclooxygenase-2 expression in pretreatment biopsy as a predictor of tumor responses after preoperative chemoradiation in rectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19021626&form=6&db=m The prognostic value of peritumoral regulatory T cells and its correlation with intratumoral cyclooxygenase-2 expression in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19027002&form=6&db=m Desmethylanhydroicaritin inhibits NF-kappaB-regulated inflammatory gene expression by modulating the redox-sensitive PI3K/PTEN/Akt pathway. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19027919&form=6&db=m Ethyl pyruvate ameliorates liver injury secondary to severe acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19031941&form=6&db=m Positive correlation between cyclooxygenase 2 and the expression of ABC transporters in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19035518&form=6&db=m Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19039588&form=6&db=m Prognostic significance of tumor iNOS and COX-2 in stage III malignant cutaneous melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19042113&form=6&db=m Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19046264&form=6&db=m Expression of cyclooxygenase-2 by equine ocular and adnexal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047067&form=6&db=m Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19047153&form=6&db=m Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19048457&form=6&db=m COX-2 expression in highly aggressive thyroid malignancies - indication for a possible therapeutic option? causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19051345&form=6&db=m Eriobotrya japonica leaf and its triterpenes inhibited lipopolysaccharide-induced cytokines and inducible enzyme production via the nuclear factor-kappaB signaling pathway in lung epithelial cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19054826&form=6&db=m Bortezomib attenuates murine collagen-induced arthritis. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19055699&form=6&db=m Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056168&form=6&db=m Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19058305&form=6&db=m Inhibitory effect of interferon-alpha-2b on expression of cyclooxygenase-2 and vascular endothelial growth factor in human hepatocellular carcinoma inoculated in nude mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19066964&form=6&db=m Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19067254&form=6&db=m Comparison of caspase genes for the induction of apoptosis following gene delivery. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19068239&form=6&db=m The anti-angiogenic effects of 1-furan-2-yl-3-pyridin-2-yl-propenone are mediated through the suppression of both VEGF production and VEGF-induced signaling. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19069312&form=6&db=m Cyclooxygenase-2 inhibitors and antioxidants in the treatment of cachexia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19075598&form=6&db=m Protective effect of NSAIDs on cancer and influence of COX-2 C(-765G) genotype. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19080686&form=6&db=m [Expression of cyclooxygenase-2 in bladder transitional cell carcinoma and the significance thereof] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19082515&form=6&db=m The inhibitory effect of Gleditsia sinensis on cyclooxygenase-2 expression in human esophageal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19083478&form=6&db=m Grape and wine polyphenols down-regulate the expression of signal transduction genes and inhibit the growth of estrogen receptor-negative MDA-MB231 tumors in nu/nu mouse xenografts. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19088039&form=6&db=m Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19093868&form=6&db=m Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19097981&form=6&db=m Persistent Inactivation of Macrophage Cyclooxygenase-2 in Mycobacterial Pulmonary Inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098866&form=6&db=m Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19098906&form=6&db=m Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19101649&form=6&db=m PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19102009&form=6&db=m EGFR, HER-2 and COX-2 levels in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19102503&form=6&db=m [Expressions of MMP-2 and COX-2 mRNA in bladder transitional cell carcinoma and their correlation] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107602&form=6&db=m Expression of COX-2 in Stomach Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107625&form=6&db=m Chlorella powder inhibits the activities of peptidase cathepsin S, PLA2, cyclooxygenase-2, thromboxane synthase, tyrosine phosphatases, tumor necrosis factor-alpha converting enzyme, calpain and kinases. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19110321&form=6&db=m Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19114773&form=6&db=m NSAIDs and the colon. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116363&form=6&db=m Massive T-lymphocyte infiltration into the host stroma is essential for fibroblast growth factor-2-promoted growth and metastasis of mammary tumors via neovascular stability. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19118057&form=6&db=m Cyclooxygenase-2 is an independent prognostic factor in gastric carcinoma patients receiving adjuvant chemotherapy and is not associated with EBV infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19123332&form=6&db=m [Effects of propyl gallate on serum inflammatory factors and protein expression of COX-2 and ICAM-1 in ischemic myocardium of rats with acute myocardial infarction] diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19123475&form=6&db=m Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19126304&form=6&db=m Effect of natsudaidain isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in RBL-2H3 cells. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132985&form=6&db=m Prognostic value of COX-2 immunohistochemical expression evaluated by quantitative image analysis in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19135346&form=6&db=m Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19136226&form=6&db=m Porcine spermatozoa inhibit post-breeding cytokine induction in uterine epithelial cells in vivo. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19136477&form=6&db=m The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138272&form=6&db=m Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cutaneous squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138835&form=6&db=m A novel single nucleotide polymorphism of the cyclooxygenase-2 gene associated with breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138933&form=6&db=m Aberrant crypt foci in the adenoma prevention with celecoxib trial. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138958&form=6&db=m Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19138967&form=6&db=m NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19139002&form=6&db=m Delphinidin attenuates neoplastic transformation in JB6 Cl41 mouse epidermal cells by blocking Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19139136&form=6&db=m NS-398, ibuprofen, and cyclooxygenase-2 RNA interference produce significantly different gene expression profiles in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19140872&form=6&db=m Inhibition of TNF-alpha-induced cyclooxygenase-2 expression by Mycobacterium bovis BCG in human alveolar epithelial A549 cells. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19147569&form=6&db=m Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148359&form=6&db=m [p53, p16 E COX-2 expression in esophageal squamous cell carcinoma and histopathological association] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148897&form=6&db=m Metabolism of anandamide by COX-2 is necessary for endocannabinoid-induced cell death in tumorigenic keratinocytes. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19151545&form=6&db=m Protective effect of a mixture of Aloe vera and Silybum marianum against carbon tetrachloride-induced acute hepatotoxicity and liver fibrosis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19152372&form=6&db=m Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19157443&form=6&db=m S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19158151&form=6&db=m Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19160427&form=6&db=m Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19161536&form=6&db=m Cyclooxygenase-2 expression on urothelial and inflammatory cells of cystoscopic biopsies and urine cytology as a possible predictive marker for bladder carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19174152&form=6&db=m Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19176489&form=6&db=m Molecular Characterization of Feline COX-2 and Expression in Feline Mammary Carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19177022&form=6&db=m Gemcitabine, irinotecan and celecoxib in patients with biliary cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19180200&form=6&db=m Expression pattern of cyclooxygenase-2 in normal rat epidermis and pilosebaceous unit during hair cycle. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19181340&form=6&db=m Effects of Dexmedetomidine on Regulating Endotoxin-Induced Up-Regulation of Inflammatory Molecules in Murine Macrophages. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19183244&form=6&db=m A Novel Protein Fraction from Sesbania grandiflora Shows Potential Anticancer and Chemopreventive Efficacy, in vitro and in vivo. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19184365&form=6&db=m Glycine- and proline-rich glycoprotein regulates the balance between cell proliferation and apoptosis for ACF formation in 1,2-dimethylhydrazine-treated A/J mice. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19187222&form=6&db=m Nucling interacts with nuclear factor-kappaB, regulating its cellular distribution. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19187440&form=6&db=m Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19187645&form=6&db=m Celecoxib plays a multiple role to peripheral blood lymphocytes and allografts in acute rejection in rats after cardiac transplantation. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19188749&form=6&db=m COX-2 expression does not correlate with microvessel density in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19189070&form=6&db=m NF-kappaB blockade upregulates Bax, TSP-1, and TSP-2 expression in rat granulation tissue. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19189639&form=6&db=m Pioglitazone, a ligand for peroxisome proliferator-activated receptor-gamma acts as an inhibitor of colon cancer liver metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19189646&form=6&db=m The guggul for chronic diseases: ancient medicine, modern targets. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19196394&form=6&db=m Molecular basis of therapeutic approaches to gastric cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19197984&form=6&db=m Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19200341&form=6&db=m Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201881&form=6&db=m Lipopolysaccharide initiates a positive feedback of epidermal growth factor receptor signaling by prostaglandin E2 in human biliary carcinoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203768&form=6&db=m COX-2 expression in canine normal and neoplastic mammary gland. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203995&form=6&db=m Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208339&form=6&db=m The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19211027&form=6&db=m Dissection of the role of paeoniflorin in the traditional Chinese medicinal formula Si-Ni-San against contact dermatitis in mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19217322&form=6&db=m Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19217469&form=6&db=m Cancer and thrombosis in women - molecular mechanisms. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19217709&form=6&db=m Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218139&form=6&db=m [Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis] diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218340&form=6&db=m Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19218449&form=6&db=m Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19227010&form=6&db=m Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19227129&form=6&db=m The effect of tumor necrosis factor-alpha (TNF-alpha, interleukin (IL)-1beta and IL-6 on prostaglandins (PG)F2alpha and E2 secretion from maternal placenta in pigs. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19227276&form=6&db=m [Role of immunohistochemical study of extracellular matrix components in the estimation of the malignant potential of adrenal pheochromocytomas] causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19231080&form=6&db=m Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase-2 signalling. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19232171&form=6&db=m [The immunohistochemical expression of cyclooxygenase 2 is inversely associated with (18)F-FDG-PET SUV values in non-small-cell lung cancers. Initial results] causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19233777&form=6&db=m Rheological, sensorial, and chemopreventive properties of milk fermented with exopolysaccharide-producing lactic cultures. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19235044&form=6&db=m Effects of dietary flaxseed on intestinal tumorigenesis in Apc(Min) mouse. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19235530&form=6&db=m Effects of a selective cyclooxygenase-1 inhibitor in SKOV-3 ovarian carcinoma xenograft-bearing mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19235531&form=6&db=m Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236238&form=6&db=m Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236750&form=6&db=m [Effect of As(2)O(3) on Expressions of COX-2 and Matrix Metalloproteinases in SGC7901 and K562 Cells.] causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239908&form=6&db=m Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239949&form=6&db=m Immunoexpression of cyclooxygenase-2 and p53 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19241124&form=6&db=m Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19244345&form=6&db=m Caveolin-1-mediated suppression of cyclooxygenase-2 via a {beta}-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19245590&form=6&db=m Overexpression of cyclooxygenase-2 in urothelial carcinoma in conjunction with tumor-associated-macrophage infiltration, hypoxia-inducible factor-1alpha expression, and tumor angiogenesis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19247274&form=6&db=m COX-2-mediated Inflammation in Fat Is Crucial for Obesity-linked Insulin Resistance and Fatty Liver. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250220&form=6&db=m Cyclooxygenase-2 expression in chronic liver diseases and hepatocellular carcinoma: an immunohistochemical study . causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250221&form=6&db=m Prostaglandin E2 receptors and COX enzymes in human hepatocellular carcinoma: role in the regulation of cell growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19252746&form=6&db=m COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19254941&form=6&db=m Role of combination therapy with aromatase and cyclooxygenase-2 inhibitors in patients with metastatic breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19258542&form=6&db=m Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19260469&form=6&db=m Coexpression of cyclooxygenase-2 and vascular endothelial growth factor in gastrointestinal stromal tumor: possible relations to pathological parameters and clinical behavior. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19262051&form=6&db=m [Case of villous tumor of the rectum presenting with severe diarrhea and electrolyte depletion syndrome] diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19264847&form=6&db=m Enhancement of doxorubicin cytotoxicity on human esophageal squamous cell carcinoma cells by indomethacin and SC236 via inhibiting P-glycoprotein activity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19265159&form=6&db=m Fas signal promotes lung cancer growth by recruiting myeloid-derived suppressor cells via cancer cell-derived PGE2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19276291&form=6&db=m A phase II study of celecoxib in combination with paclitaxel, carboplatin, and radiotherapy for patients with inoperable stage IIIA/B non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19277698&form=6&db=m Absence of circulating aldosterone attenuates foreign body reaction around surgical sutures. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19277703&form=6&db=m Comparison of cyclooxygenase-2 and CD44 mRNA expression in colorectal cancer and its relevance for prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19278989&form=6&db=m PGE2 production in oral cancer cell lines is COX-2-dependent. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280060&form=6&db=m Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280666&form=6&db=m COX-2 polymorphisms and the risk for head and neck cancer in white patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19285652&form=6&db=m Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287962&form=6&db=m SNS-032 prevents hypoxia-mediated glioblastoma cell invasion by inhibiting hypoxia inducible factor-1alpha expression. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287971&form=6&db=m Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287974&form=6&db=m Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289149&form=6&db=m Glutathione peroxidases in different stages of carcinogenesis. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289707&form=6&db=m Cyclooxygenase 2 promoter-based replication-selective adenoviral vector for hypopharyngeal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19293639&form=6&db=m AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19299804&form=6&db=m Antiinflammatory and antihyperalgesic activity of C-phycocyanin. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19303104&form=6&db=m Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19303869&form=6&db=m Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappaB induced oxidative stress and inflammation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19307727&form=6&db=m Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19307990&form=6&db=m The immune tolerance of cancer is mediated by IDO that is inhibited by COX-2 inhibitors through regulatory T cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19309229&form=6&db=m Celecoxib and melatonin in prevention of female rat mammary carcinogenesis. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19317916&form=6&db=m Identification of novel cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19318548&form=6&db=m Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19318580&form=6&db=m The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19321579&form=6&db=m Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19321801&form=6&db=m Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19326179&form=6&db=m Cyclooxygenase-2 Overexpression Predicts Poor Survival in Patients with High-grade Extremity Osteosarcoma: A Pilot Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19329856&form=6&db=m Increased expression of cyclooxygenase-2 and increased infiltration of regulatory T cells in tumors of patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19332096&form=6&db=m Analysis of interleukin (IL)-8 expression in human astrocytomas: Associations with IL-6, cyclooxygenase-2, vascular endothelial growth factor, and microvessel morphometry. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19338584&form=6&db=m Synthesis of hyaluronan in oesophageal cancer cells is uncoupled from the prostaglandin-cAMP pathway. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19340409&form=6&db=m Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19340516&form=6&db=m Neoplasms escape selective COX-2 inhibition in an animal model of breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19345476&form=6&db=m Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19345647&form=6&db=m Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19346994&form=6&db=m Clinicopathological Correlations of Cyclooxygenase-2, MDM2, and p53 Expressions in Surgically Resectable Pancreatic Invasive Ductal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19347284&form=6&db=m Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPARdelta --> 14-3-3epsilon Pathway. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19347995&form=6&db=m The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19348044&form=6&db=m Can licorice lick colon cancer? causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19362167&form=6&db=m Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19363520&form=6&db=m Cyclooxygenase inhibitors differentially modulate p73 isoforms in neuroblastoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19372053&form=6&db=m Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19375854&form=6&db=m A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19379296&form=6&db=m Expression and regulation of cyclooxygenase-2 in normal and neoplastic canine keratinocytes. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19379307&form=6&db=m Evaluation of cyclooxygenase-1 and cyclooxygenase-2 expression and the effect of cyclooxygenase inhibitors in canine prostatic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19387877&form=6&db=m Synergistic Inhibition Effect of Tumor Growth by Using Celecoxib in Combination With Oxaliplatin. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19389518&form=6&db=m Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19390242&form=6&db=m Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19391129&form=6&db=m COX-2 is induced by HGF stimulation in Met-positive thyroid papillary carcinoma cells and is involved in tumour invasiveness. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19392653&form=6&db=m The cyclooxygenase-2 inhibitor etoricoxib is a potent chemopreventive agent of colon carcinogenesis in the rat model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19393729&form=6&db=m Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-alpha and iNOS expression, which is mediated by NF-kappaB regulation, in RAW264.7 cells. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19401534&form=6&db=m Nonsteroidal anti-inflammatory drug use and endometrial cancer risk in the NIH-AARP Diet and Health Study. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19402641&form=6&db=m Anti-Inflammatory and Antiproliferative Activities of Trifolirhizin, a Flavonoid from Sophora flavescens Roots. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19405952&form=6&db=m Apigenin, a nonmutagenic dietary flavonoid suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409031&form=6&db=m Targeting the eicosanoid pathway in non-small-cell lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19410080&form=6&db=m Ozonated water improves lipopolysaccharide-induced responses of an odontoblast-like cell line. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19412426&form=6&db=m Aurora-A expression is independently associated with chromosomal instability in colorectal cancer. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19412621&form=6&db=m Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19415240&form=6&db=m NF-kappaB induces PGE(2)-synthesizing enzymes in neurons. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19420769&form=6&db=m Anti-inflammatory constituents of Sappan Lignum. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19421193&form=6&db=m Genes that mediate breast cancer metastasis to the brain. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19422084&form=6&db=m Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19423183&form=6&db=m Cigarette smoke and increased COX-2 and survivin levels in exhaled breath condensate of lung cancer patients: How hot is the link? causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19423863&form=6&db=m COX-2 Limits Prostanoid Production in Activated HUVECs and Is a Source of PGH2 for Transcellular Metabolism to PGE2 by Tumor Cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428334&form=6&db=m A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19428370&form=6&db=m Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430402&form=6&db=m COX-2 expression in malignant melanoma: a novel prognostic marker? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19430421&form=6&db=m SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19432844&form=6&db=m Cyclo-oxygenase-2 expression in photon-radiated and non-radiated uveal melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19435207&form=6&db=m [The effects of celecoxib on mammary tumorigenesis and aging in HER2/neu transgenic mice] causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19436636&form=6&db=m Inflammatory mammary carcinoma in 12 dogs: Clinical features, cyclooxygenase-2 expression, and response to piroxicam treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19440051&form=6&db=m The pro-apoptotic action of stilbene-induced COX-2 in cancer cells: Convergence with the anti-apoptotic effect of thyroid hormone. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19440670&form=6&db=m The Cyclooxygenase-2 Inhibitor Nimesulide, a Nonsteroidal Analgesic, Decreases the Effect of Radiation Therapy in Head-and-Neck Cancer Cells. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19441072&form=6&db=m Bioactive acylphloroglucinols from Hypericum densiflorum. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19443354&form=6&db=m A randomized controlled trial investigating the effects of celecoxib in patients with localized prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19445018&form=6&db=m Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19447423&form=6&db=m CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19448592&form=6&db=m Differential protein immunoexpression profiles in appendiceal mucinous neoplasms: a special reference to classification and predictive factors. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19448967&form=6&db=m The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19449050&form=6&db=m Modification of palm oil for anti-inflammatory nutraceutical properties. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19450893&form=6&db=m COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455240&form=6&db=m Global Tumor RNA Expression in Early Establishment of Experimental Tumor Growth and Related Angiogenesis following Cox-Inhibition Evaluated by Microarray Analysis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19455278&form=6&db=m Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19457709&form=6&db=m An overview on the expression of cyclooxygenase-2 in tumors of the head and neck. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19459739&form=6&db=m Paeonia japonica, Houttuynia cordata, and Aster scaber water extracts induce nitric oxide and cytokine production by lipopolysaccharide-activated macrophages. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19463183&form=6&db=m Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19465063&form=6&db=m Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19470390&form=6&db=m Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19470469&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19470791&form=6&db=m A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19471247&form=6&db=m Treatment with cyclooxygenase-2 inhibitors enables repeated administration of vaccinia virus for control of ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19483309&form=6&db=m Anti-inflammatory effect of Columbianetin on activated human mast cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19484991&form=6&db=m [Expression and clinical significance of hypoxia-inducible factor-1alpha and cyclooxygenase-2 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19497798&form=6&db=m Heterogeneous expression of cyclooxygenase-2 and inducible nitric oxide synthase within colorectal tumors: Correlation with tumor angiogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19500635&form=6&db=m Anti-inflammatory effect of coumarins isolated from Corydalis heterocarpa in HT-29 human colon carcinoma cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19505386&form=6&db=m Effects of rich-in-fat diets and highly selective COX-2 inhibitors on 7,12-dimethylbenz-(A)-anthracene-induced tumor growth. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19505918&form=6&db=m A cohort study of p27 localization in colon cancer, body mass index, and patient survival. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19506872&form=6&db=m Celecoxib prevents tumor growth in an animal model by a COX-2 independent mechanism. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509570&form=6&db=m Aromatase, cyclooxygenase 2, HER-2/neu, and p53 as prognostic factors in endometrioid endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19509584&form=6&db=m Assessment of promising protein markers for vulva cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19513071&form=6&db=m Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19517063&form=6&db=m Tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa B and Akt in diethylnitrosoamine induced lung tumors in Swiss mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519538&form=6&db=m Selective cyclooxygenase-2 (COX-2) inhibitors used for preventing or regressing cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19519665&form=6&db=m Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19526039&form=6&db=m Chunghyuldan attenuates brain microglial inflammatory response. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19544971&form=6&db=m COX-2 polymorphisms in patients with familial adenomatous polyposis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19553566&form=6&db=m Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19554635&form=6&db=m Low COX2 in tumor and upregulation in stroma mark laryngeal squamous cell carcinoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19557302&form=6&db=m Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19559517&form=6&db=m Cox-2 expression in ovarian malignancies: a review of the clinical aspects. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568414&form=6&db=m Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568714&form=6&db=m Anti-inflammatory mechanism of total glycosides of Acanthopanax Giraldii. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19571664&form=6&db=m Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19571668&form=6&db=m Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyclooxygenase-2 inhibition as chemoprevention for rat bladder carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19580182&form=6&db=m COX-2, VEGF and tumour angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19580343&form=6&db=m Immunohistochemical markers of proliferation and vascularisation in preneoplastic bronchial lesions and invasive non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584150&form=6&db=m Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19584262&form=6&db=m Cyclooxygenase-2 up-regulates ataxia telangiectasia and Rad3 related through extracellular signal-regulated kinase activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19589728&form=6&db=m Inflammation and colorectal cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19590824&form=6&db=m Dietary supplementation of silymarin protects against chemically induced nephrotoxicity, inflammation and renal tumor promotion response. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19591688&form=6&db=m Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: analysis of data from randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01). causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19594492&form=6&db=m Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19596210&form=6&db=m Spinal cord long-term potentiation (LTP) is associated with increased dorsal horn gene expression of IL-1beta, GDNF and iNOS. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19596931&form=6&db=m Discrepancies in expression and prognostic value of tumor markers in adenocarcinoma and squamous cell carcinoma in cervical cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19597825&form=6&db=m pRb2/p130 protein in relation to clinicopathological and biological variables in rectal cancers with a clinical trial of preoperative radiotherapy. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19605908&form=6&db=m COX-2 expression in canine mammary carcinomas: correlation with angiogenesis (or microvessel density) and overall survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19608016&form=6&db=m Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19609863&form=6&db=m Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD). diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19618291&form=6&db=m Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-kappaB in prostate cancer cells. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19621391&form=6&db=m Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19621664&form=6&db=m Expression of c-erbB-2 and cyclooxygenase-2 in intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19633925&form=6&db=m Effects of the Inhibition of Cyclooxygenase-2 on Human Esophageal Cancer Cells: Inhibition of Cell Proliferation and Induction of Apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19634157&form=6&db=m Docetaxel and irinotecan in recurrent or metastatic head and neck cancer: a phase 2 trial of the Eastern Cooperative Oncology Group. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638539&form=6&db=m Cyclo-oxygenase-2 overexpression is a feature of early and well-differentiated hepatocellular carcinoma with a favourable prognosis. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19638987&form=6&db=m Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19639178&form=6&db=m Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19642015&form=6&db=m Intervention of Acidophilus-casei dahi and Wheat bran against molecular alteration in colon carcinogenesis. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19653224&form=6&db=m Inhibition of lipid peroxidation, cyclooxygenase enzyme and human tumor cell proliferation by compounds in herbal water. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661321&form=6&db=m Co-inhibition of cyclooxygenase-2 and dihydropyrimidine dehydrogenase by non-steroidal anti-inflammatory drugs in tumor cells and xenografts. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19664879&form=6&db=m Enhancement of anti-tumor activity by low-dose combination of the recombinant urokinase kringle domain and celecoxib in a glioma model. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19665429&form=6&db=m Inflammation and cancer: how friendly is the relationship for cancer patients? unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19665451&form=6&db=m Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on Celecoxib-induced apoptosis. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19669667&form=6&db=m -765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19669712&form=6&db=m In Vitro Effects of Calcium Fructoborate upon Production of Inflammatory Mediators by LPS-stimulated RAW 264.7 Macrophages. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671676&form=6&db=m Cyclooxygenase-2 (COX-2) negatively regulates expression of epidermal growth factor receptor and causes resistance to gefitinib in COX-2-overexpressing cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671757&form=6&db=m Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671906&form=6&db=m Aspirin use and survival after diagnosis of colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19673886&form=6&db=m Prolonged low-dose administration of the cyclooxygenase-2 inhibitor celecoxib enhances the antitumor activity of irinotecan against neuroblastoma xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19679653&form=6&db=m Inhibition of cyclooxygenase-2 down-regulates aromatase activity and decreases proliferation of Leydig tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680997&form=6&db=m Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19682434&form=6&db=m Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19682802&form=6&db=m Neonatal bacterial infection alters fever to live and simulated infections in adulthood. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19685508&form=6&db=m Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via VEGF-C. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19686742&form=6&db=m A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19691646&form=6&db=m Cyclooxygenase-2 (COX-2) expression in canine intracranial meningiomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19703034&form=6&db=m Structure activity relationship of antiproliferative agents using multiple linear regression. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19706164&form=6&db=m Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19707506&form=6&db=m Cytoplasmic Expression of HuR is Related to Cyclooxygenase-2 Expression in Colon Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19709125&form=6&db=m Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19711347&form=6&db=m Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19712723&form=6&db=m Expression of cyclooxygenase-1/-2, microsomal prostaglandin-E synthase-1 and E-prostanoid receptor 2 and regulation of inflammatory mediators by PGE(2) in the amoeboid microglia in hypoxic postnatal rats and murine BV-2 cells. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19720908&form=6&db=m Phase II, Randomized, Placebo-Controlled Trial of Neoadjuvant Celecoxib in Men With Clinically Localized Prostate Cancer: Evaluation of Drug-Specific Biomarkers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723044&form=6&db=m Cyclooxygenase-2 expression in cervical intraepithelial neoplasia. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723114&form=6&db=m Celecoxib potentiates the anticancer effect of cisplatin on vulvar cancer cells independently of cyclooxygenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725105&form=6&db=m Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19725874&form=6&db=m Suppression of nuclear factor-kappaB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19728193&form=6&db=m 18F-FLT and 18F-FDG PET to measure response to radiotherapy combined with celecoxib in two colorectal xenograft models. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19729335&form=6&db=m Malignant salivary gland tumors and cyclo-oxygenase-2: A histopathological and immunohistochemical analysis with implications on histogenesis. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19730383&form=6&db=m The relationship between HPV16 and expression of cyclooxygenase-2, P53 and their prognostic roles in esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19730932&form=6&db=m Detection of pain-related molecules in the subchondral bone of osteoarthritic knees. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19732774&form=6&db=m Regulation of Colonic Epithelial Repair in Mice by Toll-like Receptors and Hyaluronic Acid. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19735174&form=6&db=m Elucidation of anti-inflammatory potencies of Eucommia ulmoides bark and Plantago asiatica seeds. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737966&form=6&db=m Leukotriene B4 creates a favorable microenvironment for murine melanoma growth. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737986&form=6&db=m Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19747500&form=6&db=m High-fat diet exacerbates inflammation and cell survival signals in the skin of ultraviolet B-irradiated C57BL/6 mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19747744&form=6&db=m Double blind randomized phase II study with radiation+5-fluorouracil+/-celecoxib for resectable rectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19748095&form=6&db=m Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19751908&form=6&db=m Predictive value of cyclooxygenase 2 and Bcl-2 for cervical lymph node metastasis in mucoepidermoid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19754548&form=6&db=m Cytokines, growth factors and prostaglandin synthesis in the uterus of pregnant and non-pregnant bitches: the features of placental sites. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19755515&form=6&db=m Celecoxib antagonizes perifosine's anticancer activity involving a cyclooxygenase-2-dependent mechanism. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19755647&form=6&db=m Cyclooxygenase-2 polymorphisms, aspirin treatment, and risk for colorectal adenoma recurrence--data from a randomized clinical trial. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19756737&form=6&db=m Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19757048&form=6&db=m Chemoprevention of Colonic Polyps with Balsalazide: An Exploratory, Double-Blind, Placebo-Controlled Study. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19758248&form=6&db=m Epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines is mediated through extracellular signal-regulated kinase 1/2 and p38 but is Src and nuclear factor-kappa B independent. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19758440&form=6&db=m Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759192&form=6&db=m IL-12-deficiency suppresses 12-O-tetradecanoylphorbol-13-acetate-induced skin tumor development in 7, 12-dimethylbenz(a)anthracene-initiated mouse skin through inhibition of inflammation. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759871&form=6&db=m Immunohistochemical Demonstration of Membrane-bound Prostaglandin E(2) Synthase-1 in Papillary Thyroid Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19763723&form=6&db=m Muscone Protects Vertebral End-plate Degeneration by Antiinflammatory Property. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19765729&form=6&db=m COX-2 Inhibition Improves Immune System Homeostasis and Decreases Liver Damage in Septic Rats. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19767811&form=6&db=m Effects of eccentric treadmill exercise on inflammatory gene expression in human skeletal muscle. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19771276&form=6&db=m Inhibition of Phorbol Ester-induced Mouse Skin Tumor Promotion and COX-2 Expression by Celecoxib: C/EBP as a Potential Molecular Target. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19772879&form=6&db=m Multifunctional role of VIP in prostate cancer progression in a xenograft model: Suppression by curcumin and COX-2 inhibitor NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19773434&form=6&db=m Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19773750&form=6&db=m Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776181&form=6&db=m Olive Leaf Extract and Its Main Component Oleuropein Prevent Chronic Ultraviolet B Radiation-Induced Skin Damage and Carcinogenesis in Hairless Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776585&form=6&db=m Effects of Cigarette Smoking and Restraint Stress on Human Colon Tumor Growth in Mice. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19784539&form=6&db=m Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19786019&form=6&db=m Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: A comparison study with methylprednisolone. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19788855&form=6&db=m Posttranscriptional and posttranslational determinants of cyclooxygenase expression. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19789368&form=6&db=m Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19794144&form=6&db=m Protein kinase D mediates synergistic expression of COX-2 induced by TNF-{alpha} and bradykinin in human colonic myofibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19795944&form=6&db=m Expression of cyclooxygenase-2 in canine uveal melanocytic neoplasms. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19796664&form=6&db=m Skin tumor promotion by argemone oil/alkaloid in mice: Evidence for enhanced cell proliferation, ornithine decarboxylase, cyclooxygenase-2 and activation of MAPK/NF-kappaB pathway. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19798548&form=6&db=m The effects of celecoxib, a COX-2 selective inhibitor, on acute inflammation induced in irradiated rats. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19799610&form=6&db=m Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19800419&form=6&db=m The anti-inflammatory effect of tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19802504&form=6&db=m Phase II nonrandomized study of the efficacy and safety of COX-2 inhibitor celecoxib on patients with cancer cachexia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808641&form=6&db=m Polypodium Leucotomos Extract Decreases UV-Induced Cox-2 Expression and Inflammation, Enhances DNA Repairs, and Decreases Mutagenesis in Hairless Mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19808956&form=6&db=m Tpl2 is a key mediator of arsenite-induced signal transduction. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19809186&form=6&db=m Inhibitory Effect of Phytoglycoprotein (115 kDa) on the Expression of TNF-alpha and Interleukin-1beta via Inhibition of MAP Kinase in Primary Cultured Mouse Thymocytes. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19812686&form=6&db=m Tumor-shed PGE(2) impairs IL2Rgammac-signaling to inhibit CD4 T cell survival: regulation by theaflavins. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19814734&form=6&db=m PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivo. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19815299&form=6&db=m Brevicompanine E reduces lipopolysaccharide-induced production of proinflammatory cytokines and enzymes in microglia by inhibiting activation of activator protein-1 and nuclear factor-kappaB. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19818596&form=6&db=m Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19820419&form=6&db=m Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19821125&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19824699&form=6&db=m CHARACTERIZATION OF COVALENT ADDUCTS OF NUCLEOSIDES AND DNA FORMED BY REACTION WITH LEVUGLANDIN. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825961&form=6&db=m Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19825995&form=6&db=m Amplification of Lipopolysaccharide-Induced Cytokine Synthesis in Non-Small Cell Lung Cancer/Neutrophil Cocultures. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19826177&form=6&db=m Helicobacter pylori infection in gastric cancerogenesis. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19836060&form=6&db=m Prognostic relevance of cyclooxygenase-2 (COX-2) expression in Chinese patients with prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19836219&form=6&db=m Boschniakia rossica prevents the carbon tetrachloride-induced hepatotoxicity in rat. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19837676&form=6&db=m Regulation of transforming growth factor-{beta}-dependent cyclooxygenase-2 expression in fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19838718&form=6&db=m [Crystal-induced activation of the inflammasome: gout and pseudogout.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843689&form=6&db=m Elevated Levels of Urinary Prostaglandin E Metabolite Indicate a Poor Prognosis in Ever Smoker Head and Neck Squamous Cell Carcinoma Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19844858&form=6&db=m Apricoxib, a COX-2 inhibitor for the potential treatment of pain and cancer. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19845533&form=6&db=m Cyclooxygenase-2 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19846662&form=6&db=m MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19850676&form=6&db=m Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19876598&form=6&db=m Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19884509&form=6&db=m Sulindac confers high level ischemic protection to the heart through late preconditioning mechanisms. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19885582&form=6&db=m Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin's lymphomas. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887544&form=6&db=m Experimental cancer therapy using restoration of NAD+ -linked 15-hydroxyprostaglandin dehydrogenase expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19890662&form=6&db=m TNF superfamily gene polymorphism as prognostic factor in early breast cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19891691&form=6&db=m Treatment of feline mammary tumours using chemotherapy, surgery and a COX-2 inhibitor drug (meloxicam): a retrospective study of 23 cases (2002-2007)*. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895521&form=6&db=m Prolonging androgen sensitivity in prostate cancer - a role for COX inhibitors? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895739&form=6&db=m [Effects of cyclooxygenase-2 and proliferating cell nuclear antigen on the onset and development of familial adenomatous polyposis] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19897661&form=6&db=m PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19899409&form=6&db=m Cox-2 immunohistochemical expression in epithelial ovarian carcinoma and platin sensitivity. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19900843&form=6&db=m Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903376&form=6&db=m Efficacy of different doses of aspirin in decreasing blood levels of inflammatory markers in patients with cardiovascular metabolic syndrome. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903417&form=6&db=m Do COX-2 inhibitors reduce metachronous cancer development? therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903783&form=6&db=m Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903839&form=6&db=m Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19907312&form=6&db=m Mucus hypersecretion in asthma: intracellular signalling pathways as targets for pharmacotherapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19909744&form=6&db=m Antimetastatic role of Smad4 signaling in colorectal cancer. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19910795&form=6&db=m KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19914374&form=6&db=m Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917058&form=6&db=m Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19918789&form=6&db=m Pachymic acid inhibits cell growth and modulates arachidonic acid metabolism in nonsmall cell lung cancer A549 cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19921253&form=6&db=m Establishment and characterization of a novel human malignant peripheral nerve sheath tumor cell line, FMS-1, that overexpresses epidermal growth factor receptor and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19922946&form=6&db=m Triptolide Inhibits Proliferation and Migration of Colon Cancer Cells by Inhibition of Cell Cycle Regulators and Cytokine Receptors. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925030&form=6&db=m Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925514&form=6&db=m Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925564&form=6&db=m Snail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19926935&form=6&db=m Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19933324&form=6&db=m Analgesic and Anti-Inflammatory Activities of the Methanol Extract from Pogostemon cablin. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19936622&form=6&db=m Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19939424&form=6&db=m The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19946014&form=6&db=m Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19946329&form=6&db=m The role of COX-2 in intestinal inflammation and colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19948157&form=6&db=m Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19949677&form=6&db=m The effect of cyclooxygenase-2 expression on tumor volume response in patients treated with radiotherapy for uterine cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19954945&form=6&db=m Oral carcinogenesis induced by 4-nitroquinoline 1-oxide in lecithin:retinol acyltransferase gene knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956498&form=6&db=m Expression of Cyclooxygenase-2 in Human Breast Cancer: Relationship with HER-2/neu and other Clinicopathological Prognostic Factors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956499&form=6&db=m Co-Expression of Cox-2, C-Met and beta-catenin in Cells Forming Invasive front of Gallbladder Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19956901&form=6&db=m Protective effects of fermented ginseng on streptozotocin-induced pancreatic beta-cell damage through inhibition of NF-kappaB. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19957245&form=6&db=m Evaluation of Brazilian plants on cancer chemoprevention targets in vitro. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19960513&form=6&db=m Caveolin-1 facilitates cyclooxygenase-2 protein degradation. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19962296&form=6&db=m Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss model. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19965896&form=6&db=m PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19967720&form=6&db=m Cyclooxygenase inhibitors: Scope of their use and development in cancer chemotherapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19999807&form=6&db=m [Cyclooxygenase inhibitors in chemoprevention and treatment of esophageal squamous cell carcinoma] causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20001974&form=6&db=m Cyclo-oxygenase 2 up-regulates the effect of multidrug resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004133&form=6&db=m Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment - an overview. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20004565&form=6&db=m COX-2 expression in chondrosarcoma: a role for celecoxib treatment? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20007921&form=6&db=m Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20016751&form=6&db=m Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20021866&form=6&db=m [Expression of COX-2 and VEGF and their correlation with angiogenesis in human clear cell renal cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025057&form=6&db=m Expression of cyclooxygenase-2 and microsomal prostaglandin-E synthase in amoeboid microglial cells in the developing brain and effects of cyclooxygenase-2 neutralization on BV-2 microglial cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025478&form=6&db=m Prognostic significance of apoptotic cell death in bladder cancer: a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026797&form=6&db=m Successful treatment with meloxicam, a cyclooxygenase-2 inhibitor, of patients with extra-abdominal desmoid tumors: a pilot study. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20027123&form=6&db=m Centrally administered lipopolysaccharide elicits sympathetic excitation via NAD(P)H oxidase-dependent mitogen-activated protein kinase signaling. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20027603&form=6&db=m Enhanced expression of proproliferative and antiapoptotic genes in ulcerative colitis-associated neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20028875&form=6&db=m DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20032377&form=6&db=m Expression of the CD117, COX-2 and HSP90 antigens and cell proliferation in fine-needle-aspirated cells from metastatic melanomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034753&form=6&db=m Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034758&form=6&db=m Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20035770&form=6&db=m Prostaglandin E2 upregulates survivin expression via the EP1 receptor in hepatocellular carcinoma cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20037297&form=6&db=m [The IL-6 and COX-2 expression related to sensitivity of chemoradiotherapy and prognosis in esophageal carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20038921&form=6&db=m Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20039930&form=6&db=m Suppressive effect of COX2 inhibitor on the progression of adipose inflammation in high-fat-induced obese rats. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20041097&form=6&db=m Correlation between tumor volume response to radiotherapy and expression of biological markers in patients with cervical squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20042640&form=6&db=m Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043298&form=6&db=m Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosis. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20044950&form=6&db=m Agrocybe chaxingu polysaccharide prevent inflammation through the inhibition of COX-2 and NO production. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20046424&form=6&db=m Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051365&form=6&db=m Beyond the scalpel: targeting hedgehog in skin cancer prevention. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20052522&form=6&db=m Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20060094&form=6&db=m Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20061361&form=6&db=m Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20062571&form=6&db=m Inhibitory Effect of IFN-beta, on the Antitumor Activity of Celecoxib in U87 Glioma Model. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20067543&form=6&db=m Tumour-derived prostaglandin E and transforming growth factor-beta synergize to inhibit plasmacytoid dendritic cell-derived interferon-alpha. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20068092&form=6&db=m Identification of cyclooxygenase-2 as a major actor of the transcriptomic adaptation of endothelial and tumor cells to cyclic hypoxia: effect on angiogenesis and metastases. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20069278&form=6&db=m Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20069397&form=6&db=m Correlation Between Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression in Human Colorectal Adenocarcinoma: A Cross-Sectional Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20074673&form=6&db=m The anti-inflammatory and antinociceptive effects of NF-kappaB inhibitory guanidine derivative ME10092. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20075740&form=6&db=m COX-2 polymorphisms and colorectal cancer risk: a strategy for chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20081809&form=6&db=m CD133 expression predicts for non-response to chemotherapy in colorectal cancer. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20087233&form=6&db=m The effect of repetitive transcranial magnetic stimulation on a model rat of Parkinson's disease. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093788&form=6&db=m Anti-inflammatory activity of methylene chloride fraction from Glehnia littoralis extract via suppression of NF-kappaB and mitogen-activated protein kinase activity. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20093790&form=6&db=m Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096072&form=6&db=m Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20101247&form=6&db=m Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110411&form=6&db=m COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20116423&form=6&db=m Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20118820&form=6&db=m Vascular Endothelial Growth Factor and not Cyclooxygenase 2 Promotes Endothelial Cell Viability in the Pancreatic Tumor Microenvironment. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20120033&form=6&db=m A phase 2 pilot trial of low-dose, continuous infusion, or "metronomic" paclitaxel and oral celecoxib in patients with metastatic melanoma. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20122948&form=6&db=m Leptin deficiency-induced obesity exacerbates ultraviolet B radiation-induced cyclooxygenase-2 expression and cell survival signals in ultraviolet B-irradiated mouse skin. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20122965&form=6&db=m The role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive decline induced by beta-amyloid peptide. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20132963&form=6&db=m Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20133359&form=6&db=m Ursolic Acid Attenuates D-Galactose-Induced Inflammatory Response in Mouse Prefrontal Cortex through Inhibiting AGEs/RAGE/NF-{kappa}B Pathway Activation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20136974&form=6&db=m Anti-inflammatory actions of probiotics through activating suppressor of cytokine signaling (SOCS) expression and signaling in Helicobacter pylori infection: a novel mechanism. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20139427&form=6&db=m Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20141620&form=6&db=m Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20142789&form=6&db=m Red clover extract: a source for substances that activate peroxisome proliferator-activated receptor alpha and ameliorate the cytokine secretion profile of lipopolysaccharide-stimulated macrophages. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20143255&form=6&db=m Dietary Grape Seed Proanthocyanidins Inhibit UVB-Induced Cyclooxygenase-2 Expression and Other Inflammatory Mediators in UVB-Exposed Skin and Skin Tumors of SKH-1 Hairless Mice. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20144265&form=6&db=m Localization of cyclo-oxygenase-2 in human recurrent colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145019&form=6&db=m Proanthocyanidins inhibit in vitro and in vivo growth of human non-small cell lung cancer cells by inhibiting the prostaglandin E(2) and prostaglandin E(2) receptors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145033&form=6&db=m Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20145612&form=6&db=m Factors that contribute to faecal cyclooxygenase-2 mRNA expression in subjects with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20147609&form=6&db=m Lymphocyte responses exacerbate angiotensin II-dependent hypertension. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20155627&form=6&db=m Piceatannol inhibits phorbol ester-induced NF-kappa B activation and COX-2 expression in cultured human mammary epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20159031&form=6&db=m mPGES-1 as a target for cancer suppression A comprehensive invited review "Phospholipase A(2) and lipid mediators" causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20160714&form=6&db=m Methylation Status of Genes in Non-Neoplastic Mucosa From Patients With Ulcerative Colitis-Associated Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20166930&form=6&db=m Progress in COX-2 inhibitors: a journey so far. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20170702&form=6&db=m TOP1 and 2, polysaccharides from Taraxacum officinale, attenuate CCl(4)-induced hepatic damage through the modulation of NF-kappaB and its regulatory mediators. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20178602&form=6&db=m Cyclooxygenase-2 enhances alpha2beta1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179211&form=6&db=m Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179228&form=6&db=m Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20179298&form=6&db=m Chronic cyclooxygenase-2 inhibition promotes myofibroblast-associated intestinal fibrosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20180845&form=6&db=m Novel synthetic gluco-disaccharide RSCL-0409--a lipopolysaccharide-induced Toll-like receptor-mediated signalling antagonist. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192567&form=6&db=m Curcumin: from food spice to cancer prevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192574&form=6&db=m Cyclooxygenase-2 Expression in Cervical Squamous Cell Carcinoma: the Significance of Expression in Neoplastic Cells within the Lymphovascular Space. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20199731&form=6&db=m [Protective effects of curcumin on neonatal rats with necrotizing enterocolitis] ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20200425&form=6&db=m PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20201783&form=6&db=m Flavonoids of the Genus Iris (Iridaceae). unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20202090&form=6&db=m Celecoxib enhances the inhibitory effect of cisplatin on Tca8113 cells in human tongue squamous cell carcinoma in vivo and in vitro. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20204301&form=6&db=m p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20206237&form=6&db=m Chondroitin sulfate inhibits lipopolysaccharide-induced inflammation in rat astrocytes by preventing nuclear factor kappa B activation. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20207364&form=6&db=m COX-1 and COX-2 Expression in Canine Cutaneous, Oral and Ocular Melanocytic Tumours. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20209608&form=6&db=m Intratumoral forkhead box P3-positive regulatory T cells predict poor survival in cyclooxygenase-2-positive uveal melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20213098&form=6&db=m Circulating cycloxygenase-2 in patients with tobacco-related intraoral squamous cell carcinoma and evaluation of its peptide inhibitors as potential antitumor agent. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20213764&form=6&db=m Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20215464&form=6&db=m Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20215519&form=6&db=m Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20216081&form=6&db=m Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20217088&form=6&db=m Pioglitazone modulates tumor cell metabolism and proliferation in multicellular tumor spheroids. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20220763&form=6&db=m Effect of 17-alpha hydroxyprogesterone caproate on the production of tumor necrosis factor-alpha and the expression of cyclooxygenase-2 in lipopolysaccharide-treated gravid human myometrial explants. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20222044&form=6&db=m Differential effects between cyclooxygenase-2 inhibitors and siRNA on vascular endothelial growth factor production in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20222943&form=6&db=m Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226002&form=6&db=m Molecular basis of traditional Chinese medicine in cancer chemoprevention. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227160&form=6&db=m Cyclo-oxygenase type 2 is dysregulated in breast ductal carcinoma in situ and correlates with poor outcome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227521&form=6&db=m Decrease in expression or activity of cytosolic phospholipase A(2)alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20234320&form=6&db=m Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20237495&form=6&db=m Enhanced Death Ligand-Induced Apoptosis in Cutaneous SCC Cells by Treatment with Diclofenac/Hyaluronic Acid Correlates with Downregulation of c-FLIP. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20237896&form=6&db=m COX-2 is associated with proliferation and apoptosis markers and serves as an independent prognostic factor in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304053&form=6&db=m Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH(2))D(3)) and prostaglandin E(2) (PGE(2)) serum level in ovarian cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20305341&form=6&db=m Evaluation of estrogen receptor alpha, estrogen receptor beta, progesterone receptor, and cKIT expression in desmoids tumors and their role in determining treatment options. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20307736&form=6&db=m Effect of cytosolic phospholipase A2 on proinflammatory cytokine-induced bone resorptive genes including receptor activator of nuclear factor kappa B ligand in human dental pulp cells. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332009&form=6&db=m Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332150&form=6&db=m Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332213&form=6&db=m HuR knockdown changes the oncogenic potential of oral cancer cells. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332326&form=6&db=m Cyclooxygenase-2 genetic variants are associated with survival in unresectable locally advanced non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20338775&form=6&db=m May cyclooxygenase-2 (COX-2), p21 and p27 expression affect prognosis and therapeutic strategy of patients with malignant pleural mesothelioma? causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20339581&form=6&db=m The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20346139&form=6&db=m Expression and prognostic significance of cox-2 and p-53 in hodgkin lymphomas: a retrospective study. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20349107&form=6&db=m The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20351014&form=6&db=m Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353702&form=6&db=m [Gastric carcinoma and chronic gastritis: epigenetic regulation of CDH1 (E-Cadherin), CDKN2A (p16INK4A), PTGS2 (COX-2) and EGFR genes through methylation] causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353998&form=6&db=m Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20367887&form=6&db=m Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20369487&form=6&db=m [Relationship of cyclooxygenase-2 and multidrug resistance associated factors to chemosensitivities in gastrointestinal carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20373884&form=6&db=m Cyclooxygenase-2 expression in retinoblastoma: an immunohistochemical analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20376296&form=6&db=m Standardized ginger (Zingiber officinale) extract reduces bacterial load and suppresses acute and chronic inflammation in Mongolian gerbils infected with cagAHelicobacter pylori. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20377179&form=6&db=m Protective effect of quercetin against arsenite-induced COX-2 expression by targeting PI3K in rat liver epithelial cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20381235&form=6&db=m Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382007&form=6&db=m Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20383690&form=6&db=m Antitumor and antimetastatic effects of licochalcone A in mouse models. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20387815&form=6&db=m Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20388082&form=6&db=m Lipoxygenase inhibitors for cancer prevention: promises and risks. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20388085&form=6&db=m Inflammatory responses in embryonal cardiomyocytes exposed to LPS challenge: an in vitro model of deciphering the effects of LPS on the heart. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20389170&form=6&db=m Enhancement of the sensitivity of renal cell carcinoma cells to fas-mediated cytotoxicity and apoptosis by the selective cyclooxygenase-2 inhibitor JTE-522. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20392831&form=6&db=m Gonadotropins Induce Tumor Cell Migration and Invasion by Increasing Cyclooxygenases Expression and Prostaglandin E2 Production in Human Ovarian Cancer Cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20396537&form=6&db=m Cyclooxygenase-2: a potential target in human cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20396544&form=6&db=m Clinical value of cyclooxygenase-2 expression in human breast carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20397266&form=6&db=m Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20400974&form=6&db=m Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20401641&form=6&db=m Clinical significance of Cox-2, Survivin and Bcl-2 expression in hepatocellular carcinoma (HCC). causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20404772&form=6&db=m Similar antineoplastic effects of nimesulide, a selective COX-2 inhibitor, and prostaglandin E1 on B16-F10 murine melanoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20409773&form=6&db=m COX-2 is overexpressed in primary prostate cancer with metastatic potential and may predict survival. A comparison study between COX-2, TGF-beta, IL-10 and Ki67. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412400&form=6&db=m Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20422426&form=6&db=m Potential role of cyclooxygenase-2 on the regulation of the drug efflux transporter ABCG2 in breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20427430&form=6&db=m Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428208&form=6&db=m COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF). causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428812&form=6&db=m Potential of molecular targeted therapy of HER-2 and Cox-2 for invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20430759&form=6&db=m Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20436219&form=6&db=m Bile acids are multifunctional modulators of the Barrett's carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20438297&form=6&db=m Paracrine effect of canine allogenic umbilical cord blood-derived mesenchymal stromal cells mixed with beta-tricalcium phosphate on bone regeneration in ectopic implantations. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20438867&form=6&db=m Investigation of anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20439179&form=6&db=m Silica-based nanoparticle uptake and cellular response by primary microglia. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20442318&form=6&db=m Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446020&form=6&db=m 17beta-Estradiol inhibits prostaglandin E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446925&form=6&db=m The value of MG7-Ag and COX-2 for predicting malignancy in gastric precancerous lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20448209&form=6&db=m Ablation of the Transcription Factor Nrf2 Promotes Ischemia-Induced Neovascularization by Enhancing the Inflammatory Response. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20450834&form=6&db=m Selected pro-inflammatory factor transcripts in bovine endometrial epithelial cells are regulated during the oestrous cycle and elevated in case of subclinical or clinical endometritis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20459551&form=6&db=m Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20460721&form=6&db=m Magnolol suppresses metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in PC-3 human prostate carcinoma cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20462604&form=6&db=m Role of COX-2 in Tumorospheres Derived from a Breast Cancer Cell Line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20465821&form=6&db=m Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20471230&form=6&db=m Protective effects of asiaticoside on septic lung injury in mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20477063&form=6&db=m Eicosanoids in inflammation and cancer: the role of COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20482876&form=6&db=m p38 mediates mechanical allodynia in a mouse model of type 2 diabetes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20484034&form=6&db=m Persistent cyclooxygenase-2 inhibition downregulates NF-{kappa}B, resulting in chronic intestinal inflammation in the min/+ mouse model of colon tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20486934&form=6&db=m Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20488889&form=6&db=m Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20495296&form=6&db=m Coenzyme Q10 attenuated DMH-induced precancerous lesions in SD rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20498636&form=6&db=m Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-kappaB activation. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501859&form=6&db=m Combination effects of salvianolic acid B with low-dose celecoxib on inhibition of head and neck squamous cell carcinoma growth in vitro and in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20507599&form=6&db=m Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20508278&form=6&db=m COX-2 as a target for cancer chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20513002&form=6&db=m Colon carcinoma cell interaction with liver sinusoidal endothelium inhibits organ-specific antitumor immunity through interleukin-1-induced mannose receptor in mice. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20514441&form=6&db=m Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20515870&form=6&db=m Potent antitumor activity in experimental hepatocellular carcinoma by adenovirus-mediated coexpression of TRAIL and shRNA against COX-2. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20518847&form=6&db=m Growth hormone releasing hormone induces the expression of nitric oxide synthase. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20521538&form=6&db=m Effects of caffeoylquinic acid derivatives and C-flavonoid from Lychnophora ericoides on in vitro inflammatory mediator production. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20526717&form=6&db=m Celecoxib enhances radiosensitivity in medulloblastoma-derived CD133-positive cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530427&form=6&db=m Interaction of cyclooxygenase 2 genotype and smoking habit in Taiwanese lung cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530431&form=6&db=m Increased serum progesterone and estradiol correlate to increased COX-2 tissue expression in cervical intraepithelial neoplasia. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530583&form=6&db=m Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20532752&form=6&db=m Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: the roles of NF-kappaB and crosstalk between the extrinsic and intrinsic apoptotic pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20536410&form=6&db=m COX-2 expression in human breast carcinomas: correlation with clinicopathological features and prognostic molecular markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20549218&form=6&db=m Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20549385&form=6&db=m Cyclooxygenase (COX)-1 Activity Precedes the COX-2 Induction in Abeta-Induced Neuroinflammation. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20552344&form=6&db=m Targeting the tumor microenvironment using photodynamic therapy combined with inhibitors of cyclooxygenase-2 or vascular endothelial growth factor. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20553228&form=6&db=m Nutritional targeting of cyclooxygenase-2 for colon cancer prevention. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20554880&form=6&db=m Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20556396&form=6&db=m Effect of beta blocker combined with COX-2 inhibitor on colonic anastomosis in rats. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20558731&form=6&db=m Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20566208&form=6&db=m Perioperative moxifloxacin treatment in rats subjected to deep hypothermic circulatory arrest: Reduction in cerebral inflammation but without improvement in cognitive performance. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20570123&form=6&db=m Anti-inflammatory effects of the willow bark extract STW 33-I (Proaktiv((R))) in LPS-activated human monocytes and differentiated macrophages. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20571967&form=6&db=m Hypermethylation of RAR?2 correlates with high COX-2 expression and poor prognosis in patients with colorectal carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20577575&form=6&db=m Posttranscriptional Regulation of Cyclooxygenase 2 Expression in Colorectal Cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582552&form=6&db=m Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20585313&form=6&db=m ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20589743&form=6&db=m Inhibitory effect of MIL glycoprotein on expression of pro-inflammatory mediators in carbon tetrachloride-induced mice liver damage. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20592629&form=6&db=m Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20594217&form=6&db=m Potentially functional COX-2-1195G>A polymorphism increases the risk of digestive system cancers: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20595240&form=6&db=m Genes for prostaglandin synthesis, transport and inactivation are differentially expressed in human uterine tissues, and the prostaglandin F synthase AKR1B1 is induced in myometrial cells by inflammatory cytokines. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20596620&form=6&db=m Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20599447&form=6&db=m Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fate. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20606309&form=6&db=m A new cyclooxygenase-2 inhibitor, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4-dien-3-one (GL63) suppresses cyclooxygenase-2 gene expression in human lung epithelial cancer cells: coupled mRNA stabilization and posttranscriptional inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609401&form=6&db=m Dimethyl cardamonin inhibits lipopolysaccharide-induced inflammatory factors through blocking NF-kappaB p65 activation. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609543&form=6&db=m Ursodeoxycholic acid and chemoprevention of colorectal cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20615394&form=6&db=m Targeting COX-2 expression by natural compounds: A promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20617408&form=6&db=m PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20621084&form=6&db=m Effects of sappanchalcone on the cytoprotection and anti-inflammation via heme oxygenase-1 in human pulp and periodontal ligament cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20625420&form=6&db=m RNAi-based strategies for cyclooxygenase-2 inhibition in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20627335&form=6&db=m Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for urinary bladder cancer in North India. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20628001&form=6&db=m Novel application of proton pump inhibitor for the prevention of colitis-induced colorectal carcinogenesis beyond acid suppression. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631072&form=6&db=m Suppression of integrin alpha3beta1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631638&form=6&db=m Prognostic stratification of stage IIIA pN2 non-small cell lung cancer by hierarchical clustering analysis of tissue microarray immunostaining data: an Alpe Adria Thoracic Oncology Multidisciplinary Group study (ATOM 014). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20631885&form=6&db=m Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20635443&form=6&db=m Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20640462&form=6&db=m S-propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: involvement of ERK1/2 and NF-kappaB pathway in rats. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20647315&form=6&db=m Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20649594&form=6&db=m Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20652953&form=6&db=m The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20653782&form=6&db=m Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20654727&form=6&db=m Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20659490&form=6&db=m Inflammatory effects of inhaled sulfur mustard in rat lung. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660237&form=6&db=m Nitric oxide synthases, cyclooxygenase-2, nitrotyrosine, and angiogenesis in chondrosarcoma and their relation to prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20660715&form=6&db=m Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20662032&form=6&db=m Anti-inflammatory effects of low-level light emitting diode therapy on Achilles tendinitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20664734&form=6&db=m Apoptotic Effect of Tolfenamic Acid in KB Human Oral Cancer Cells: Possible Involvement of the p38 MAPK Pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20669087&form=6&db=m Cancer Chemopreventive Activity of Maslinic Acid: Suppression of COX-2 Expression and Inhibition of NF-kappaB and AP-1 Activation in Raji Cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20673501&form=6&db=m [Detection of EGFR and COX-2 expression by immunohistochemical method on a tissue microarray section in lung cancer and biological significance] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20675158&form=6&db=m COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20675368&form=6&db=m Tilapia hepcidin 2-3 peptide modulates lipopolysaccharide-induced cytokines and inhibits tumor necrosis factor-alpha through cyclooxygenase-2 and phosphodiesterase 4D. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20677482&form=6&db=m Tumor necrosis factor-alpha-induced cyclooxygenase-2 overexpression in eutopic endometrium of women with endometriosis by stromal cell culture through nuclear factor-kappaB activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20683050&form=6&db=m Prognostic evaluation of COX-2 expression in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20686223&form=6&db=m Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20686383&form=6&db=m Cyclooxygenase-2 gene polymorphisms and risk of cervical cancer in a North Indian population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20686774&form=6&db=m Signet-ring cell carcinoma of colorectum-current perspectives and molecular biology. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20691996&form=6&db=m Overexpression of COX-2 in celecoxib-resistant breast cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20695774&form=6&db=m New pharmacotherapy for airway mucus hypersecretion in asthma and COPD: targeting intracellular signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20697066&form=6&db=m Role of vitamin and mineral supplementation and aspirin use in cancer survivors. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20698743&form=6&db=m Effect of selective COX-2 inhibitor, celecoxib on adjuvant-induced arthritis model in irradiated rats. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20704950&form=6&db=m Aspirin triggers formation of anti-inflammatory mediators: New mechanism for an old drug. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20709621&form=6&db=m Inhibitive effect of celecoxib on the adhesion and invasion of human tongue squamous carcinoma cells to extracellular matrix via down regulation of MMP-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20709632&form=6&db=m Cyclooxygenase-independent inhibitory effects on T cell activation of novel 4,5-dihydro-3 trifluoromethyl pyrazole cyclooxygenase-2 inhibitors. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20716400&form=6&db=m [The Effects of Interfering COX-2 Gene Expression on Malignant Proliferation of Human Lung Adenocarcinoma A2 Cell in vitro.] causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717005&form=6&db=m Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717114&form=6&db=m Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20720404&form=6&db=m Effects of paricalcitol and enalapril on atherosclerotic injury in mouse aortas. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20722966&form=6&db=m Inhibition of CCAAT/enhancer binding protein ? expression by chrysin in microglial cells results in anti-inflammatory and neuroprotective effects. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20724486&form=6&db=m An ?-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-?B in rats with TNBS-induced colitis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20727496&form=6&db=m Gene expression of oncogenes, antimicrobial peptides, and cytokines in the development of oral leukoplakia. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20727973&form=6&db=m Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20728343&form=6&db=m Toll-like receptor (TLR) 7 and TLR8 expression on CD133+ cells in colorectal cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20729081&form=6&db=m Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731190&form=6&db=m Expression of cyclooxygenase-2 in neoplasms of the mammary gland in bitches. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731191&form=6&db=m Evaluation of immunohistochemical expression of P-glycoprotein in neoplasms of the mammary gland in bitches. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20731664&form=6&db=m Nucleotide-binding domain of phosphoglycerate kinase 1 reduces tumor growth by suppressing COX-2 expression. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20733946&form=6&db=m PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20739850&form=6&db=m HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20740367&form=6&db=m Protease-activated receptor-2 regulates cyclooxygenase-2 expression in human bile duct cancer via the pathways of mitogen-activated protein kinases and nuclear factor kappa B. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20801552&form=6&db=m Therapeutic potential of sulindac hydroxamic acid against human pancreatic and colonic cancer cells. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20804550&form=6&db=m COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20807565&form=6&db=m Mouse brain plasmalogens are targets for hypochlorous acid-mediated modification in vitro and in vivo. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20808059&form=6&db=m The -765C allele of the cyclooxygenase-2 gene as a potential risk factor of colorectal cancer: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20809087&form=6&db=m Association of COX-2 Promoter Polymorphism with Gastrointestinal Tract Cancer in Iran. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20817448&form=6&db=m Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20818651&form=6&db=m Molecular typing of epithelial ovarian carcinomas using inflammatory markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20823108&form=6&db=m Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20828592&form=6&db=m In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20830783&form=6&db=m COX-2-mediated regulation of VEGF-C in association with lymphangiogenesis and lymph node metastasis in lung cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20831192&form=6&db=m Role of Nrf2 in Suppressing LPS-Induced Inflammation in Mouse Peritoneal Macrophages by Polyunsaturated Fatty Acids Docosahexaenoic Acid and Eicosapentaenoic Acid. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20833521&form=6&db=m Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-?B and STAT-1 activation. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20837956&form=6&db=m Phase III randomized trial assessing rofecoxib in the adjuvant setting of colorectal cancer: final results of the VICTOR trial. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20839630&form=6&db=m Inhibitory effects of black pepper (Piper nigrum) extracts and compounds on human tumor cell proliferation, cyclooxygenase enzymes, lipid peroxidation and nuclear transcription factor-kappa-B. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20842472&form=6&db=m Evaluation of the role of oxidative stress in chemopreventive action of fish oil and celecoxib in the initiation phase of 7,12-dimethyl benz(?)anthracene-induced mammary carcinogenesis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20843270&form=6&db=m Protective effects of Danshensu on liver injury induced by omethoate in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20846124&form=6&db=m Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of gallbladder carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20846456&form=6&db=m Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20847752&form=6&db=m Preclinical evaluation of a gene therapy treatment for transitional cell carcinoma. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20850297&form=6&db=m MexTAg mice exposed to asbestos develop cancer that faithfully replicates key features of the pathogenesis of human mesothelioma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20856806&form=6&db=m Diclofenac inhibits tumor growth in a murine model of pancreatic cancer by modulation of VEGF levels and arginase activity. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20857495&form=6&db=m Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20858219&form=6&db=m Selective COX-1 Inhibition: A Therapeutic Target to be Reconsidered. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20858484&form=6&db=m Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20864511&form=6&db=m {gamma}-Tocotrienol Inhibits Pancreatic Tumors and Sensitizes Them to Gemcitabine Treatment by Modulating the Inflammatory Microenvironment. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20872780&form=6&db=m Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876365&form=6&db=m Cyclooxygenase-2 Expression in Animal Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876730&form=6&db=m Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20877234&form=6&db=m Anti-Inflammatory activity of chrysophanol through the suppression of NF-kappaB/caspase-1 activation in vitro and in vivo. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878062&form=6&db=m Mechanisms behind COX-1 and COX-2 inhibition of tumor growth in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878085&form=6&db=m Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20878581&form=6&db=m [Correlation of cyclooxygenase 2 expression with microlymphatic density and its clinical significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20879982&form=6&db=m Exploiting cyclooxygenase-(in)dependent properties of COX-2 inhibitors for malignant glioma therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20881304&form=6&db=m Reduced Choroidal Neovascular Membrane Formation in Cyclooxygenase-2 Null Mice. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20929443&form=6&db=m Enhanced expression of pro-inflammatory mediators and liver X receptor-regulated lipogenic genes in nonalcoholic fatty liver disease and hepatitits C. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20932327&form=6&db=m Effect of ?-3 and ?-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20932730&form=6&db=m Urban air pollution produces up-regulation of myocardial inflammatory genes and dark chocolate provides cardioprotection. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20937254&form=6&db=m Role of leukotriene B(4) in celecoxib-mediated anticancer effect. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20937454&form=6&db=m Gastric cancer: an infectious disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20937726&form=6&db=m Carcinogenic Effects of Whole Life Exposure to Inorganic Arsenic in CD1 Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20937780&form=6&db=m Inhibition of bacterial MDR by celecoxib, a cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20951077&form=6&db=m A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20951146&form=6&db=m Curative effects of hydrogen sulfide against acetaminophen-induced hepatotoxicity in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20955148&form=6&db=m The Targets of Curcumin. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960108&form=6&db=m Heparanase-1 and Cyclooxygenase-2: prognostic indicators of malignancy in pheochromocytomas. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960565&form=6&db=m Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20961430&form=6&db=m Abalone visceral extract inhibit tumor growth and metastasis by modulating Cox-2 levels and CD8+ T cell activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20966498&form=6&db=m [The role of stromal mast cells in the modification of CD4+CD25+Foxp³ regulatory T cells, Th17 lymphocytes and cytotoxic lymphocytes Tc1 in the development and progression of tumor]. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20971513&form=6&db=m Guggulsterone suppresses LPS induced inflammation of human middle ear epithelial cells (HMEEC). diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20974686&form=6&db=m Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E2 and prostaglandin E2 receptors. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20977452&form=6&db=m Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21029036&form=6&db=m A transparent artificial dura mater made of silk fibroin as an inhibitor of inflammation in craniotomized rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21040737&form=6&db=m Apigenin inhibits tumor necrosis factor alpha plus high glucose induced-LOX-1 expression in human endothelial cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042835&form=6&db=m Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21043843&form=6&db=m Platelet activation by cells isolated from human tumor tissues: effect of cyclooxygenase blockade. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21044318&form=6&db=m Increasing CD44+/CD24- tumor stem cells, and upregulation of COX-2 and HDAC6, as major functions of HER2 in breast tumorigenesis. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21054139&form=6&db=m Celecoxib and radioresistant glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects. Laboratory investigation. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21057160&form=6&db=m Synergistic effect of celecoxib on 5-fluorouracil-induced apoptosis in hepatocellular carcinoma patients. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21058188&form=6&db=m Avenanthramides inhibit proliferation of human colon cancer cell lines in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21059239&form=6&db=m Polymorphisms in regulatory regions of cyclooxygenase-2 gene and breast cancer risk in Brazilians: a case-control study. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21062968&form=6&db=m The effects of the stromal cell-derived cyclooxygenase-2 metabolite prostaglandin E2 on the proliferation of colon cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21071999&form=6&db=m Pifithrin-?, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21075851&form=6&db=m Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21078168&form=6&db=m COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21078262&form=6&db=m Inflammation and cancer: tumor initiation, progression and metastasis, and Chinese botanical medicines. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21080047&form=6&db=m Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21080421&form=6&db=m Stercurensin inhibits nuclear factor-?B-dependent inflammatory signals through attenuation of TAK1-TAB1 complex formation. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21081159&form=6&db=m Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21081469&form=6&db=m NF-?B targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21081470&form=6&db=m Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21087344&form=6&db=m The radiosensitization effect of NS398 on esophageal cancer stem cell-like radioresistant cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21088406&form=6&db=m Role of cyclooxygenase-2 in pathogenesis and prevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21095217&form=6&db=m Hepatoprotective activity of berberine is mediated by inhibition of TNF-?, COX-2, and iNOS expression in CCl(4)-intoxicated mice. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21105986&form=6&db=m Bilharzial vs non-bilharzial related bladder cancer: pathological characteristics and value of cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21108693&form=6&db=m Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21113620&form=6&db=m The effect of COX-2 inhibitor on capecitabine-induced hand-foot syndrome in patients with stage II/III colorectal cancer: a phase II randomized prospective study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21116687&form=6&db=m Prolactin alters the mRNA expression of osteoblast-derived osteoclastogenic factors in osteoblast-like UMR106 cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21116821&form=6&db=m Adipocyte-derived lipids increase angiotensin-converting enzyme (ACE) expression and modulate macrophage phenotype. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118643&form=6&db=m [Suppression of COX-2 protein to cell apoptosis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21118647&form=6&db=m [Correlation of time-density curve of CT enhancement with angiogenesis in lung cancer.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21124790&form=6&db=m The functional -765G?C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21127968&form=6&db=m Estrogen or Estrogen Receptor Agonist Inhibits Lipopolysaccharide Induced Microglial Activation and Death. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21131835&form=6&db=m COX-2 expression in nonepithelial ovarian malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21133589&form=6&db=m Cyclooxygenase-2 expression in gastrointestinal stromal tumours. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21140097&form=6&db=m Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21143185&form=6&db=m Radiation Induced Non-targeted Response: Mechanism and Potential Clinical Implications. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21145881&form=6&db=m Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves ?v?5 integrin, ILK and AP-1-dependent pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21147199&form=6&db=m Cigarette smoking, cyclooxygenase-2 pathway and cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21152137&form=6&db=m Relation of the expression of cyclooxygenase-2 in colorectal adenomas and adenocarcinomas to angiogenesis and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21153458&form=6&db=m Methylation status and overexpression of COX-2 in Tunisian patients with ductal invasive breast carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21154115&form=6&db=m Epigenetics, an early event in the modulation of gene expression by inositol hexaphosphate in ethylnitrosourea exposed mouse lungs. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21154234&form=6&db=m Role of nitric oxide in the regulation of fibrogenic factors in experimental liver fibrosis in mice. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21160376&form=6&db=m Cyclooxygenase-2 (COX-2) expression in solid pseudopapillary tumor of the pancreas: a pilot study. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21160593&form=6&db=m Anti-carcinogenic properties of curcumin on colorectal cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21161467&form=6&db=m HuR expression is a marker of poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21163769&form=6&db=m [Application of non-steroidal anti-inflammatory drugs to enhance 5-fluorouracil efficacy in experimental systems]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21166741&form=6&db=m Promoter hypermethylation of cyclooxygenase-2 gene in esophageal squamous cell carcinoma. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21166751&form=6&db=m Improved cancer specific-survival in patients with carcinoma invading bladder muscle expressing cyclo-oxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21176181&form=6&db=m Time-dependent mRNA expression of selected pro-inflammatory factors in the endometrium of primiparous cows postpartum. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21177768&form=6&db=m Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-{kappa}B and STAT3 pathways in head and neck cancer cells. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21180996&form=6&db=m Cox-2 and its association with prognostic factors and response to primary chemotherapy in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21182498&form=6&db=m Immunohistochemical expression of cyclooxygenage-2 in melanocytic skin lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21185708&form=6&db=m Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187016&form=6&db=m [Growth inhibition of NS-398 combined with cisplatin on human lung adenocarcinoma cells and its mechanism.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187081&form=6&db=m Cyclooxygenase-2 in oncogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187179&form=6&db=m Nafamostat mesilate attenuates colonic inflammation and mast cell infiltration in the experimental colitis. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21189177&form=6&db=m [Expressions of cyclooxygenase-2 and vascular endothelial growth factor in human lung cancer tissue.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21205474&form=6&db=m [Effects of celecoxib combined with fluvastatin on tumor growth and cell apoptosis in a xenograft model of hepatocellar carcinoma]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21206978&form=6&db=m Heme oxygenase-1 promotes angiogenesis in urothelial carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21214483&form=6&db=m Evaluation of selected lichens from iceland for cancer chemopreventive and cytotoxic activity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21216846&form=6&db=m p-HPEA-EDA, a phenolic compound of virgin olive oil, activates AMP-activated protein kinase to inhibit carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219959&form=6&db=m Protective effect of Chrysanthemum indicum Linne against 1-methyl-4-phenylpridinium ion and lipopolysaccharide-induced cytotoxicity in cellular model of Parkinson's disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21220497&form=6&db=m Celecoxib can induce vascular endothelial growth factor expression and tumor angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21221032&form=6&db=m Cyclooxygenase-2 supports tumor proliferation in vestibular schwannomas. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21224828&form=6&db=m Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21234362&form=6&db=m Inflammatory mechanisms of neurodegeneration in toxin-based models of Parkinson's disease. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21234531&form=6&db=m Celecoxib enhances radiation response of secondary bone tumors of a human non-small cell lung cancer via antiangiogenesis in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21234610&form=6&db=m Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21238650&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses metastatic disease without affecting primary tumor growth in a murine model of Ewing sarcoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21239530&form=6&db=m Lung-derived soluble mediators are pathogenic in ventilator-induced lung injury. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21240382&form=6&db=m Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21245412&form=6&db=m Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21246838&form=6&db=m [Preventive effects of berberine on experimental colon cancer and relationship with cyclooxygenase-2 expression]. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21247366&form=6&db=m Amelioration of experimental colitis by a novel nanoselenium-silymarin mixture. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21251407&form=6&db=m [Study of COX-2 expression and angiogenesis in non-small cell lung cancer.] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21261644&form=6&db=m Resveratrol and apoptosis. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21261645&form=6&db=m Chemopreventive effects of resveratrol and resveratrol derivatives. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21261791&form=6&db=m 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone promoted gastric cancer growth through prostaglandin E receptor (EP2 and EP4) in vivo and in vitro. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21264790&form=6&db=m Chemopreventive effects of dietary canola oil on colon cancer development. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268076&form=6&db=m Stercurensin inhibits nuclear factor-?B-dependent inflammatory signals through attenuation of TAK1-TAB1 complex formation. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268127&form=6&db=m Upregulation of the EP1 receptor for prostaglandin E(2) promotes skin tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268131&form=6&db=m p38 MAP kinase plays a functional role in UVB-Induced mouse skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21273602&form=6&db=m Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21277871&form=6&db=m Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21280565&form=6&db=m Celecoxib mitigates cigarette smoke induced oxidative stress in mice. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285160&form=6&db=m A 24-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy of Oral SCIO-469, a p38 Mitogen-activated Protein Kinase Inhibitor, in Patients with Active Rheumatoid Arthritis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285293&form=6&db=m Cytokines present in smokers' serum interact with smoke components to enhance endothelial dysfunction. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21285980&form=6&db=m HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21290412&form=6&db=m Calpeptin attenuated apoptosis and intracellular inflammatory changes in muscle cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21292918&form=6&db=m Cyclooxygenase-2 Expression Is Related With Localization, Proliferation, and Overall Survival in Canine Melanocytic Neoplasms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21292998&form=6&db=m TNF-{alpha} potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21294088&form=6&db=m Immunohistochemical expression of cycloxygenase-2 in astrocytoma: correlation with angiogenesis, tumor progression and survival. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21299897&form=6&db=m Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21301321&form=6&db=m The influence of cyclooxygenase-1 expression on the efficacy of cyclooxygenase-2 inhibition in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21303260&form=6&db=m Phenethyl isothiocyanate inhibits 12-o-tetradecanoylphorbol-13-acetate-induced inflammatory responses in mouse skin. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21303331&form=6&db=m Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21304218&form=6&db=m Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21309483&form=6&db=m Cyclooxygenase-2 and survivin in superficial urothelial carcinoma of the bladder and correlation with intratumoural microvessel density. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21310944&form=6&db=m Macrophages induce COX-2 expression in breast cancer cells: Role of IL-1{beta} auto-amplification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21312242&form=6&db=m Further evaluation of a novel nano-scale gene vector for in vivo transfection of siRNA. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21319995&form=6&db=m Association Between Single Nucleotide Polymorphisms in the Cyclooxygenase-2, Tumor Necrosis Factor-?, and Vascular Endothelial Growth Factor-A Genes, and Susceptibility to Hepatocellular Carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21320305&form=6&db=m Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21320400&form=6&db=m [Cyclooxygenase-2 expression in female pulmonary adenocarcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21324306&form=6&db=m Effects of pergolide mesylate on transduction efficiency of PEP-1-catalase protein. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21324923&form=6&db=m COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21330379&form=6&db=m Isorhamnetin Suppresses Skin Cancer through Direct Inhibition of MEK1 and PI3-K. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343834&form=6&db=m Cyclooxygenase-2 confers growth advantage to syngeneic pancreatic cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21345578&form=6&db=m Targeting apoptosis pathways by Celecoxib in cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21350102&form=6&db=m Expression of galectin-3, nm-23, and cyclooxygenase-2 could potentially discriminate between benign and malignant pheochromocytoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21352962&form=6&db=m CTGF inhibits cell motility and COX-2 expression in oral cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21354147&form=6&db=m Microsomal Prostaglandin E Synthase-1 Inhibits PTEN and Promotes Experimental Cholangiocarcinogenesis and Tumor Progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21354293&form=6&db=m Inhibitory effect of Physalis alkekengi L. var. franchetii extract and its chloroform fraction on LPS or LPS/IFN-?-stimulated inflammatory response in peritoneal macrophages. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21355070&form=6&db=m Serial changes in the expression of breast cancer-related proteins in response to neoadjuvant chemotherapy. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21371829&form=6&db=m Immunohistochemical COX-2 overexpression correlates with HER-2/neu overexpression in invasive breast carcinomas: A pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21375325&form=6&db=m Anti-Inflammatory Effects of Supercritical Carbon Dioxide Extract and Its Isolated Carnosic Acid from Rosmarinus officinalis Leaves. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21376777&form=6&db=m Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21384098&form=6&db=m Lack of Alpha-Synuclein Modulates Microglial Phenotype In Vitro. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21384185&form=6&db=m Interaction between adipose tissue stromal cells and gastric cancer cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21384343&form=6&db=m Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21384460&form=6&db=m Association between areca-stimulated vimentin expression and the progression of head and neck cancers. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21391199&form=6&db=m 17?-estradiol aggravated temporomandibular joint inflammation through NF-?B pathway in ovariectomized rats. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21401513&form=6&db=m Interactions of the aryl hydrocarbon receptor with inflammatory mediators: beyond CYP1A regulation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21401528&form=6&db=m Celecoxib reduces fluidity and decreases metastatic potential of colon cancer cell lines irrespective of COX-2 expression. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21403827&form=6&db=m Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21412163&form=6&db=m Cyclooxygenase-2 Is an Independent Predictor of Poor Prognosis in Uterine Leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21417632&form=6&db=m Escin attenuates cerebral edema induced by acute omethoate poisoning. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21417802&form=6&db=m Inflammatory responses of RAW 264.7 macrophages upon exposure to nanoparticles: Role of ROS-NF?B signaling pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21419457&form=6&db=m Predictive Factors for Malignant Pheochromocytoma: Analysis of 136 Patients. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424030&form=6&db=m Immunohistochemical evaluation of COX-2 expression in HPV-positive cervical squamous intraepithelial lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424032&form=6&db=m Expression of VEGF, VEGFR, EGFR, COX-2 and MVD in cervical carcinoma, in relation with the response to radio-chemotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21426663&form=6&db=m [The Expression and Clinical Significance of HIF-1?, COX-2 and E-cadherin in Patients with Lung Adenocarcinoma.] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21428416&form=6&db=m Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in Mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21430074&form=6&db=m Enforced Expression of miR-101 inhibits prostate cancer cell growth by modulating cyclooxygenase-2 pathway in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21432910&form=6&db=m Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21434881&form=6&db=m Arvelexin isolated from the Brassica rapa abolishes inducible NF-?B activation by inhibiting IKK activation, thereby suppressing NF-?B-regulated pro-inflammatory gene expression. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21435451&form=6&db=m Expression of prostaglandin e synthases in periodontitis immunolocalization and cellular regulation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21437112&form=6&db=m Curcumin improves prostanoid ratio in diabetic mesenteric arteries associated with cyclooxygenase-2 and NF-?B suppression. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21437756&form=6&db=m COX2 Expression Predicts Resistance to Chemoradiotherapy in Esophageal Squamous Cell Carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443099&form=6&db=m Expression of COX-2, survivin in regional lymph node metastases of gastric carcinoma and the correlation with prognosis. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443470&form=6&db=m Biology of Cox-2: An Application in Cancer Therapeutics. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21449918&form=6&db=m Kaempferol acts through mitogen-activated protein kinases and protein kinase B/Akt to elicit protection in a model of neuroinflammation in BV2 microglial cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21450910&form=6&db=m Macrophages programmed by apoptotic cells promote angiogenesis via prostaglandin E2. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21459756&form=6&db=m Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21464033&form=6&db=m Induction of Retinoid X Receptor Activity and Consequent Upregulation of p21WAF1/CIP1 by Indenoisoquinolines in MCF7 Cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21466841&form=6&db=m Antioxidant, antinociceptive, and anti-inflammatory activities of Xanthii Fructus extract. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21468627&form=6&db=m Interleukin-4 Modulates the Inflammatory Response in Ifosfamide-Induced Hemorrhagic Cystitis. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21472198&form=6&db=m Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21475876&form=6&db=m Antitumor effects of a cyclooxygenase-2 inhibitor, meloxicam, alone and in combination with radiation and/or 5-fluorouracil in cultured tumor cells. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476602&form=6&db=m Isolation and Characterization of Two Flavonoids, Engeletin and Astilbin, from the Leaves of Engelhardia roxburghiana, and Their Potential Anti-inflammatory Properties. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21476934&form=6&db=m Prognostic Significance of Cyclooxygenase-2 and Response to Chemotherapy in Invasive Ductal Breast Carcinoma Patients by Real Time Surface Plasmon Resonance Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21478098&form=6&db=m Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in normal and pathological human oral mucosa. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479220&form=6&db=m Influence of Caloric Restriction on Constitutive Expression of NF-?B in an Experimental Mouse Astrocytoma. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479487&form=6&db=m Cyclooxygenase-2 expression in invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21480361&form=6&db=m Suppression of LPS-induced inflammatory and NF-?B responses by anomalin in RAW 264.7 macrophages. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21480365&form=6&db=m Nuclear receptor retinoid-related orphan receptor ?1 modulates the metabolic activity of human osteoblasts. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21481000&form=6&db=m Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21482445&form=6&db=m Interferon-? plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21486220&form=6&db=m A cross-talk between NFAT and NF-?B Pathways is Crucial for Nickel-Induced COX-2 expression in Beas-2B cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21487015&form=6&db=m Adenomatous polyposis coli protein associates with C/EBP beta and increases Bacillus anthracis edema toxin-stimulated gene expression in macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21487892&form=6&db=m Clinical and Immunomodulatory Effects of Celecoxib Plus Interferon-Alpha in Metastatic Renal Cell Carcinoma Patients with COX-2 Tumor Immunostaining. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21496105&form=6&db=m Potential relevance of cyclooxygenase-2 expression in keratocystic odontogenic tumours - an immunohistochemical study. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21501596&form=6&db=m Cyanidin-3-glucoside suppresses B[a]PDE-induced cyclooxygenase-2 expression by directly inhibiting Fyn kinase activity. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21504385&form=6&db=m Can tissue microarray-based analysis of protein expression predict recurrence of stage Ta bladder cancer? diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21507199&form=6&db=m IL-10 production in non-small cell lung carcinoma patients is regulated by ERK, P38 and COX-2. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21517752&form=6&db=m The interplay between indoleamine 2,3-dioxygenase 1 (IDO1) and cyclooxygenase (COX)-2 in chronic inflammation and cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21530501&form=6&db=m Immunosensors for quantifying cyclooxygenase 2 pain biomarkers. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21533404&form=6&db=m Cyclooxygenase-2 gene expression in human breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21533525&form=6&db=m Clinical significance of vasculogenic mimicry in human gliomas. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21538574&form=6&db=m Interaction of Cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21555117&form=6&db=m Rifampicin inhibits microglial inflammation and improves neuron survival against inflammation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556222&form=6&db=m Anti-inflammatory effect of the water fraction from hawthorn fruit on LPS-stimulated RAW 264.7 cells. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21559538&form=6&db=m A novel integrative network approach to understand the interplay between cardiovascular disease and other complex disorders. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21569199&form=6&db=m COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21570441&form=6&db=m Anti-inflammatory effects of fucoidan through inhibition of NF-?B, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21572400&form=6&db=m Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21576350&form=6&db=m Selective PGE2 Suppression Inhibits Colon Carcinogenesis and Modifies Local Mucosal Immunity. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21589857&form=6&db=m Hypoxia and prostaglandin E receptor 4 signalling pathways synergise to promote endometrial adenocarcinoma cell proliferation and tumour growth. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21600223&form=6&db=m COX-2 expression is correlated with VEGF-C, lymphangiogenesis and lymph node metastasis in human cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21602450&form=6&db=m Analysis of promoters and expression-targeted gene therapy optimization based on doubling time and transfectability. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21607999&form=6&db=m Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21615988&form=6&db=m Levosulpiride, (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl) methyl]-2-methoxybenzamide, enhances the transduction efficiency of PEP-1-ribosomal protein S3 in vitro and in vivo. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21622115&form=6&db=m Costunolide inhibits proinflammatory cytokines and iNOS in activated murine BV2 microglia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21631167&form=6&db=m Luteolin inhibits microglial inflammation and improves neuron survival against inflammation. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21633901&form=6&db=m Attenuation of the cardiac inflammatory changes and lipid anomalies by (-)-epigallocatechin-gallate in cigarette smoke-exposed rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21638077&form=6&db=m Impairment of breast cancer cell invasion by COX-2-specific inhibitor NS398: roles of CXCR4 and of uPA system. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21640445&form=6&db=m Synthesis and preliminary in vitro biological evaluation of new carbon-11-labeled celecoxib derivatives as candidate PET tracers for imaging of COX-2 expression in cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21647997&form=6&db=m Polygoni Rhizoma Inhibits Inflammatory Response through Inactivation of Nuclear Factor-kappaB and Mitogen Activated Protein Kinase Signaling Pathways in RAW264.7 Mouse Macrophage Cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656078&form=6&db=m The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21666716&form=6&db=m Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21678473&form=6&db=m Overexpression of cyclooxygenase-2 in NCI-H292 human alveolar epithelial carcinoma cells: Roles of p38 MAPK, ERK-1/2, and PI3K/PKB signaling proteins. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21679035&form=6&db=m Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21680706&form=6&db=m Statin use and colorectal cancer risk according to molecular subtypes in two large prospective cohort studies. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21682897&form=6&db=m Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an anti-inflammatory cyclooxygenase-2 (COX-2) pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21683430&form=6&db=m Expression of cyclooxygenase-2 (COX-2) and p53 in neighboring invasive and in situ components of breast tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21687953&form=6&db=m Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte growth factor in endometrial cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21689364&form=6&db=m The use of molecular markers as a method to predict the response to neoadjuvant therapy for advanced stage rectal adenocarcinoma. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21696706&form=6&db=m Ibuprofen inhibits neuroinflammation and attenuates white matter damage following hypoxia-ischemia in the immature rodent brain. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21696999&form=6&db=m Plasma levels of vascular endothelial growth factor during and after radiotherapy in combination with celecoxib in patients with advanced head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21699021&form=6&db=m Inhibition of invasion and experimental metastasis of murine melanoma cells by Ipomoea obscura (L.) is mediated through the down-regulation of inflammatory mediators and matrix-metalloproteinases. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21702720&form=6&db=m Targeting human inducible regulatory T cells (Tr1) in patients with cancer: blocking of adenosine-prostaglandin E(2) cooperation. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705299&form=6&db=m Protective role of selenium against over-expression of cancer-related apoptotic genes induced by o-cresol in rats. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705614&form=6&db=m Luteolin, a Novel Natural Inhibitor of Tumor Progression Locus 2 Serine/Threonine Kinase, Inhibits Tumor Necrosis Factor-{alpha}-Induced Cyclooxygenase-2 Expression in JB6 Mouse Epidermis Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705955&form=6&db=m Cyclooxygenase-2 Polymorphisms and Pancreatic Cancer Susceptibility. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21711123&form=6&db=m Asiasari sieboldii suppresses inflammatory mediators through the induction of hemeoxygenase-1 expression in RAW264.7 cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21724701&form=6&db=m CCL20 Stimulates Proinflammatory Mediator Synthesis in Human Fibroblast-like Synoviocytes Through a MAP Kinase-dependent Process with Transcriptional and Posttranscriptional Control. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21725607&form=6&db=m Stephania delavayi Diels. inhibits breast carcinoma proliferation through the p38 MAPK/NF-?B/COX-2 pathway. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21726131&form=6&db=m Anti-inflammatory and analgesic effects of human placenta extract. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21728052&form=6&db=m COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21730361&form=6&db=m COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21732411&form=6&db=m Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and enhanced prostaglandin E2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21733838&form=6&db=m Prevention of colitis-associated colorectal cancer with 8-hydroxydeoxyguanosine. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21734230&form=6&db=m The Cox-2 -1195 G > A polymorphism and cancer risk: a meta-analysis of 25 case-control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21734388&form=6&db=m Colon cancer: a civilization disorder. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21739481&form=6&db=m The EP1 receptor for prostaglandin E2 promotes the development and progression of malignant murine skin tumors. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21741371&form=6&db=m Discovery of a novel COX-2 inhibitor as an orally potent anti-pyretic and anti-inflammatory drug: Design, synthesis, and structure-activity relationship. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21743491&form=6&db=m Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/?-catenin signaling axis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21745461&form=6&db=m COX-2 inhibitors block chemotherapeutic agent-induced apoptosis prior to commitment in hematopoietic cancer cells. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21750550&form=6&db=m In vitro and in vivo inhibitory effect of three Cox-2 inhibitors and epithelial-to-mesenchymal transition in human bladder cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21750557&form=6&db=m Exposure to cyclooxygenase-2 inhibitors and risk of cancer: nested case-control studies. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21761157&form=6&db=m Frondoside A inhibits breast cancer metastasis and antagonizes prostaglandin E receptors EP4 and EP2. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21762277&form=6&db=m Clinicopathological significance of cyclooxygenase-2 and cell cycle-regulatory proteins expression in patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763448&form=6&db=m Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21763710&form=6&db=m Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer cells. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21765608&form=6&db=m Prebiotic treatment reduced preneoplastic lesions through the downregulation of toll like receptor 4 in a chemo-induced carcinogenic model. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21771729&form=6&db=m Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21774591&form=6&db=m Inhibition of Lipopolysaccharide-Induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression by 4-[(2'-O-acetyl-?-L-Rhamnosyloxy)Benzyl]Isothiocyanate from Moringa oleifera. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21775152&form=6&db=m Effects of ?-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21779349&form=6&db=m Smoking and COX-2 Functional Polymorphisms Interact to Increase the Risk of Gastric Cardia Adenocarcinoma in Chinese Population. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21781874&form=6&db=m (1?3)-?-d-Glucan stimulates nitric oxide generation and cytokine mRNA expression in macrophages. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21783751&form=6&db=m Prevention of collagen-induced arthritis in mice by Cervus korean TEMMINCK var. mantchuricus Swinhoe. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21785593&form=6&db=m Pancreatic cancer cell lines can induce prostaglandin e2 production from human blood mononuclear cells. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21790228&form=6&db=m Expression of miR-143 Reduces Growth and Migration of Human Bladder Carcinoma Cells by Targeting Cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21792195&form=6&db=m Radiation-enhancement of MDA-MB-231 breast cancer cell invasion prevented by a cyclooxygenase-2 inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21793834&form=6&db=m Tocotrienols: inflammation and cancer. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21793847&form=6&db=m Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21798652&form=6&db=m Cyclooxigenase-2 Levels are Increased in the Lung Tissue and Bronchial Tumors of Patients with Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21806609&form=6&db=m Inhibitory Effects of Glycoprotein Isolated from Laminaria japonica on Lipopolysaccharide-Induced Pro-Inflammatory Mediators in BV2 Microglial Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21809372&form=6&db=m Anti-inflammatory effect of pelubiprofen, 2-[4-(oxocyclohexylidenemethyl)-phenyl]propionic acid, mediated by dual suppression of COX activity and LPS-induced inflammatory gene expression via NF-?B inactivation. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813027&form=6&db=m Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21815141&form=6&db=m Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: A potential new model for oral cancer. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21816843&form=6&db=m Cardiovascular Risk Markers and Mechanisms in Targeting the COX Pathway for Colorectal Cancer Prevention. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21822285&form=6&db=m Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21822307&form=6&db=m A common single-nucleotide polymorphism in cyclooxygenase-2 disrupts microRNA-mediated regulation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21824723&form=6&db=m Suppression of carbonyl reductase expression enhances malignant behaviour in uterine cervical squamous cell carcinoma: Carbonyl reductase predicts prognosis and lymph node metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21830942&form=6&db=m Cooperative Enhancement of Radiosensitivity After Combined Treatment of 17-(Allylamino)-17-Demethoxygeldanamycin and Celecoxib in Human Lung and Colon Cancer Cell Lines. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21835258&form=6&db=m The COX-2 inhibitor Celecoxib enhances the sensitivity of KB/VCR oral cancer cell lines to Vincristine by down-regulating P-glycoprotein expression and function. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21838704&form=6&db=m Dual Function of Nitric Oxide in Carcinogenesis, Reappraisal. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21840302&form=6&db=m Indomethacin induces cellular morphological change and migration via epithelial-mesenchymal transition in A549 human lung cancer cells: A novel cyclooxygenase-inhibition-independent effect. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21840784&form=6&db=m Cyclooxygenase-2 immunoexpression in breast cancer: Progesterone receptor influence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21842653&form=6&db=m [Gambogenic acid inhibits proliferation of A549 cells through apoptosis-inducing]. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21846141&form=6&db=m Composition and Mechanism of Antitumor Effects of Hericium erinaceus Mushroom Extracts in Tumor-Bearing Mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21846384&form=6&db=m Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21847126&form=6&db=m Aspirin and cancer: has aspirin been overlooked as an adjuvant therapy? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21847707&form=6&db=m The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-?B pathway. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21848619&form=6&db=m Effect of cyclooxygenase inhibitors in a xenograft model of canine mammary tumours. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21848701&form=6&db=m Functional Genetic Variations of Cyclooxygenase-2 and Susceptibility to Acute Myeloid Leukemia in a Chinese Population. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21849808&form=6&db=m Inactivation of COX-2, HMLH1 and CDKN2A Gene by Promoter Methylation in Gastric Cancer: Relationship with Histological Subtype, Tumor Location and Helicobacter pylori Genotype. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856294&form=6&db=m 15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856398&form=6&db=m Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-?B activation in lipopolysaccharide-induced BV2 microglial cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21857970&form=6&db=m Quercetin Suppresses Cyclooxygenase-2 Expression and Angiogenesis through Inactivation of P300 Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21862119&form=6&db=m Angiogenesis and molecular markers in advanced epithelial ovarian cancer: A retrospective study. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21862873&form=6&db=m Cox-2 inhibitors induce early c-Myc downregulation and lead to expression of differentiation markers in leukemia cells. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21864702&form=6&db=m Regulation of inflammation in cancer by eicosanoids. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21867538&form=6&db=m Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21874253&form=6&db=m Lipopolysaccharide initiates a bypass feedback loop of epidermal growth factor receptor signaling by HPS70-induced COX-2 in H22 hepatocarcinoma cells. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21874258&form=6&db=m Cyclooxygenase-2 expression is not associated with clinical outcome in synovial sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21875660&form=6&db=m Comparison on the anti-inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21876437&form=6&db=m Antitumor promoting potential of selected phytochemicals derived from spices: a review. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21882253&form=6&db=m Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21882257&form=6&db=m Silibinin modulates TNF-? and IFN-? mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21883026&form=6&db=m Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21895406&form=6&db=m Leukemic cells modulate induction of COX-2 in human stromal fibroblasts. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21900596&form=6&db=m Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21902213&form=6&db=m Hydrogen tunneling steps in cyclooxygenase-2 catalysis. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21905284&form=6&db=m Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21907301&form=6&db=m COX-2 and PGE2-dependent immunomodulation in breast cancer. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21909878&form=6&db=m Nitric Oxide (NO) and Cyclooxygenase-2 (COX-2) Cross-Talk in Co-Cultures of Tumor Spheroids with Normal Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21912077&form=6&db=m The angiogenic switch for vascular endothelial growth factor-A and cyclooxygenase-2 in prostate carcinoma: correlation with microvessel density, androgen receptor content and Gleason grade. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21919080&form=6&db=m A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21922518&form=6&db=m Inhibition of inflammation and oxidative stress by Angelica dahuricae radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21924350&form=6&db=m Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21926111&form=6&db=m Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21934214&form=6&db=m Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: a pilot study. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21935918&form=6&db=m Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21937212&form=6&db=m Antimetastatic activity of pinosylvin, a natural stilbenoid, is associated with the suppression of matrix metalloproteinases. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21939640&form=6&db=m IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21939759&form=6&db=m Novel selective Cox-2 inhibitors induce apoptosis in Caco-2 colorectal carcinoma cell line. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21940022&form=6&db=m Stemodin-derived analogues with lipid peroxidation, cyclooxygenase enzymes and human tumour cell proliferation inhibitory activities. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21946257&form=6&db=m Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21951967&form=6&db=m 1-(5-bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] suppresses pro-inflammatory responses by blocking NF-?B and MAPK signaling pathways in activated microglia. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21953546&form=6&db=m Noninvasive imaging identifies new roles for cyclooxygenase-2 in choline and lipid metabolism of human breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21964530&form=6&db=m Serum vascular endothelial growth factor and COX-2/5-LOX inhibition in advanced non-small cell lung cancer: Cancer and Leukemia Group B 150304. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21965779&form=6&db=m Efficacy of meloxicam in combination with preoperative chemotherapy for breast cancer - Japan Breast Cancer Research Network (JBCRN) 02-1 trial. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21971413&form=6&db=m Rottlerin enhances IL-1?-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21971589&form=6&db=m Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21971889&form=6&db=m Inhibitor of growth-4 mediates chromatin modification and has a suppressive effect on tumorigenesis and innate immunity. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21976127&form=6&db=m Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21976141&form=6&db=m Notch2-induced COX-2 expression enhancing gastric cancer progression. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21978392&form=6&db=m Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factor. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21980345&form=6&db=m Targeting KSHV/HHV-8 latency with COX-2 selective inhibitor nimesulide: a potential chemotherapeutic modality for primary effusion lymphoma. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21981137&form=6&db=m Multifaceted link between cancer and inflammation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21984018&form=6&db=m Synthesis, characterisation and biological evaluation of copper and silver complexes based on acetylsalicylic acid. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21986672&form=6&db=m Mangiferin decreases inflammation and oxidative damage in rat brain after stress. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21986945&form=6&db=m Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21990410&form=6&db=m Randomized, placebo-controlled phase III study of docetaxel plus carboplatin with celecoxib and cyclooxygenase-2 expression as a biomarker for patients with advanced non-small-cell lung cancer: the NVALT-4 study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21993002&form=6&db=m Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21995864&form=6&db=m Effect of nonselective and selective COX-2 inhibitors on memory dysfunction, glutathione system, and tumor necrosis factor alpha level against cerebral ischemia reperfusion injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21999735&form=6&db=m Role of Resveratrol and its Analogues in the Treatment of Neurodegenerative Diseases: Focus on Recent Discoveries. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22000259&form=6&db=m [Analysis of HIF-1? and COX-2 expression in tumor stroma and correlation with the degree of neoplasm invasiveness in laryngeal cancer--preliminary study]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001128&form=6&db=m Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002714&form=6&db=m Prostaglandin E2 EP receptors as therapeutic targets in breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002749&form=6&db=m Cyclooxygenase-2 and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22006370&form=6&db=m Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22009064&form=6&db=m Cyclooxygenase- and lipoxygenase-mediated DNA damage. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22012553&form=6&db=m The role of the EP receptors for prostaglandin E2 in skin and skin cancer. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22013489&form=6&db=m Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22014124&form=6&db=m Expression levels of cyclooxygenase-2, tumor necrosis factor-? and inducible NO synthase in placental tissue of normal and preeclamptic pregnancies. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22015691&form=6&db=m Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22015819&form=6&db=m COX-derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22017396&form=6&db=m Increased levels of COX-2 in oral lichen planus supports an autoimmune cause of the disease. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22020925&form=6&db=m Prostaglandin catabolic enzymes as tumor suppressors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22023613&form=6&db=m Nrf2 and NF-?B modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22023987&form=6&db=m Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22034055&form=6&db=m Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22036979&form=6&db=m Caffeic acid attenuates 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced NF-?B and COX-2 expression in mouse skin: abrogation of oxidative stress, inflammatory responses and proinflammatory cytokine production. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22037828&form=6&db=m Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22037941&form=6&db=m The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038018&form=6&db=m Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038215&form=6&db=m Different expression of cyclooxygenase-2 (COX-2) in selected nonmelanocytic human cutaneous lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038216&form=6&db=m Expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma: correlations with clinicopathologic features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22044139&form=6&db=m Chronic psychosocial stress increases the risk for inflammation-related colon carcinogenesis in male mice. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22048655&form=6&db=m NS398 induces apoptosis in non-small cell lung cancer cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22048943&form=6&db=m Prognostic significance of cyclooxygenase-2, epidermal growth factor receptor 1, and microvascular density in gastric cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22049153&form=6&db=m The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22066110&form=6&db=m Up-regulation of cyclooxygenase-2-derived prostaglandin E(2) in colon cancer cells resistant to 5-fluorouracil. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22079567&form=6&db=m Evaluation of Cyclooxygenase-2 Expression in Canine Mast Cell Tumours. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22081106&form=6&db=m Cyclooxygenase-2 expression in esophageal epithelium before and after photodynamic therapy for Barrett's esophagus with high-grade dysplasia or intramucosal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22081376&form=6&db=m COX-2 and survivin reduction may play a role in berberine-induced apoptosis in human ductal breast epithelial tumor cell line. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22088344&form=6&db=m The impact of cyclooxygenase-2 and vascular endothelial growth factor C immunoexpression on the prognosis of penile carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22093778&form=6&db=m [Histone H3 acetylation of tumor necrosis factor-alpha and cyclooxygenase-2 in patients with type 2 diabetes]. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22093832&form=6&db=m Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-?-treated A549 cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22100845&form=6&db=m Role of macrophage colony-stimulating factor (M-CSF)-dependent macrophages in gastric ulcer healing in mice. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22104269&form=6&db=m Systematic analyses of genes associated with radiosensitizing effect by celecoxib, a specific cyclooxygenase-2 inhibitor. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22119125&form=6&db=m From COX-2 inhibitor nimesulide to potent anti-cancer agent: synthesis, in vitro, in vivo and pharmacokinetic evaluation. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22120676&form=6&db=m Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22122360&form=6&db=m DIFFERENTIAL INHIBITION OF TUMOUR CELL-INDUCED PLATELET AGGREGATION BY NICOTINATE ASPIRIN PRODRUG (ST0702) AND ASPIRIN. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22122764&form=6&db=m Pharmacology and cellular/molecular mechanisms of action of aspirin and non-aspirin NSAIDs in colorectal cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22128347&form=6&db=m LCB 03-0110, a Novel Pan-Discoidin Domain Receptor/c-Src Family Tyrosine Kinase Inhibitor, Suppresses Scar Formation by Inhibiting Fibroblast and Macrophage Activation. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22129484&form=6&db=m Metformin may antagonize Lin28 and/or Lin28B activity, thereby boosting let-7 levels and antagonizing cancer progression. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22138502&form=6&db=m Mycobacterium indicus pranii downregulates MMP-9 and iNOS through COX-2 dependent and TNF-? independent pathway in mouse peritoneal macrophages in vitro. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22145808&form=6&db=m Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22146892&form=6&db=m Disarming suppressor cells to improve immunotherapy. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159437&form=6&db=m Renal histology and immunohistochemistry after acute hemorrhage in rats under sevoflurane and ketoprofen effect. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159471&form=6&db=m Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: involvement of CCAAT/enhancer binding protein ? and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22161831&form=6&db=m Non-steroidal anti-inflammatory drugs target the pro-tumorigenic extracellular matrix of the postpartum mammary gland. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22168384&form=6&db=m Protein kinase A antagonist inhibits ?-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in ApcMin/+ mice. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22172229&form=6&db=m Preventive effects of curcumin on the development of azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db obese mice. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22176677&form=6&db=m Modulation of humoral immune responses and inhibition of proinflammatory cytokines and nitric oxide production by 10-methoxycanthin-6-one. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22176740&form=6&db=m Risperidone normalizes increased inflammatory parameters and restores anti-inflammatory pathways in a model of neuroinflammation. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22179165&form=6&db=m Analysis of angiogenic factors and cyclooxygenase-2 expression in cartilaginous tumors- clinical and histological correlation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22181070&form=6&db=m Phloretin Inhibits Phorbol Ester-Induced Tumor Promotion and Expression of Cyclooxygenase-2 in Mouse Skin: Extracellular Signal-Regulated Kinase and Nuclear Factor-?B as Potential Targets. causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22185916&form=6&db=m Magnesium chenoursodeoxycholic acid ameliorates carbon tetrachloride-induced liver fibrosis in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22189681&form=6&db=m Effect of silk fibroin peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in a mice edema model. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22198606&form=6&db=m Hepatoprotective effects of total saponins isolated from Taraphochlamys affinis against carbon tetrachloride induced liver injury in rats. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22200969&form=6&db=m The effects of cyclooxygenase-2 gene silencing by siRNA on cell proliferation, cell apoptosis, cell cycle and tumorigenicity of Capan-2 human pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203870&form=6&db=m Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NF?B Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203921&form=6&db=m Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesions. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22206958&form=6&db=m Maximal standardized uptake value on FDG-PET is correlated with cyclooxygenase-2 expression in patients with lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22209001&form=6&db=m Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22213142&form=6&db=m Inhibition of cyclooxygenase-2 enhances immunotherapy against experimental brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22213328&form=6&db=m Expression of prostaglandin- and vitamin D-metabolising enzymes in benign and malignant breast cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22214447&form=6&db=m Ginsenoside Rg1 Attenuates Lipopolysaccharide-Induced Inflammatory Responses Via the Phospholipase C-?1 Signaling Pathway in Murine BV-2 Microglial Cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22214867&form=6&db=m Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22218775&form=6&db=m The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22224493&form=6&db=m Anthocyanin-rich açai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228328&form=6&db=m Expression of Ezrin, Mmp-9 and Cox-2 in 50 Chordoma Specimens: A Clinical and Immunohistochemical Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22228906&form=6&db=m Decreased Toll-interacting protein and peroxisome proliferator-activated receptor ? are associated with increased expression of Toll-like receptors in colon carcinogenesis. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22231745&form=6&db=m Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22234093&form=6&db=m A study on expression pattern of cyclooxygenase-2 in carcinoma of cervix. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22235799&form=6&db=m COX-2 and c-kit expression in canine gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22236721&form=6&db=m Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22240079&form=6&db=m Bioassay-guided isolation of an alkaloid with antiangiogenic and antitumor activities from the extract of Fissistigma cavaleriei root. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22242594&form=6&db=m Antitumor effect of a generation 4 polyamidoamine dendrimer/cyclooxygenase-2 antisense oligodeoxynucleotide complex on breast cancer in vitro and in vivo. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22250858&form=6&db=m Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the ?-carrageenan-induced paw edema model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22258871&form=6&db=m Cyclooxygenase Isoenzyme-2 and Vascular Endothelial Growth Factor are Associated with Poor Prognosis in Esophageal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22263894&form=6&db=m Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2'-Des-methyl-sulindac Sulfide Scaffold. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22267101&form=6&db=m Cinobufocini inhibits NF-?B and COX-2 activation induced by TNF-? in lung adenocarcinoma cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22268531&form=6&db=m The nonsteroidal anti-inflammatory drug indomethacin activates the eIF2alpha kinase PKR, causing a translational block in human colorectal cancer cells. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22276108&form=6&db=m Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22285625&form=6&db=m Addendum: Gamma-tocopherol, cox-2, and cancer risk. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22286316&form=6&db=m Cyclooxygenase-2 expression in proliferative Ki-67-positive breast cancers is associated with poor outcomes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22287649&form=6&db=m Prevalence of 5-Lipoxygenase Expression in Canine Osteosarcoma and the Effects of a Dual 5-Lipoxygenase/Cyclooxygenase Inhibitor on Osteosarcoma Cells In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22289528&form=6&db=m Observation of curative efficacy and prognosis following combination chemotherapy with celecoxib in the treatment of advanced colorectal cancer. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22293631&form=6&db=m A Phase 2 Cancer Chemoprevention Biomarker Trial of Isoflavone G-2535 (Genistein) in Presurgical Bladder Cancer Patients. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22301800&form=6&db=m Elevated levels of the Steroidogenic Factor-1 are associated with over-expression of CYP19 in an Estrogen producing testicular Leydig cell tumour. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22303922&form=6&db=m Spirodela polyrhiza (L.) Sch. ethanolic extract inhibits LPS-induced inflammation in RAW264.7 cells. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22305882&form=6&db=m Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: Involvement of reactive oxygen species and NF-?B pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22306906&form=6&db=m Modulation of host natural killer cell functions in breast cancer via prostaglandin E2 receptors EP2 and EP4. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22307941&form=6&db=m Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1? and inhibited by peroxisome proliferator activated receptor ? agonist. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22308510&form=6&db=m Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22327864&form=6&db=m Pharmacological and Pharmacokinetic Studies with Agaricoglycerides, Extracted from Grifola frondosa, in Animal Models of Pain and Inflammation. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22329896&form=6&db=m Inhibition of cell survival, cell cycle progression, tumor growth and cyclooxygenase-2 activity in MDA-MB-231 breast cancer cells by camphorataimide B. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22339795&form=6&db=m Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22343740&form=6&db=m [A case of favorable response after combination treatment with interferon-? and cyclooxygenase-2 inhibitor against metastatic renal cell carcinoma]. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22348284&form=6&db=m Preparation and in vitro evaluation of meloxicam-loaded PLGA nanoparticles on HT-29 human colon adenocarcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22348469&form=6&db=m Solid variant of aneurysmal bone cyst in the tibia treated with simple curettage without bone graft: a case report. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22350949&form=6&db=m Nadroparin Sodium Activates Nrf2/HO-1 Pathway in Acetic Acid-Induced Colitis in Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22351517&form=6&db=m The possible separation of 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation and hyperplasia by compound A. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22353218&form=6&db=m Immunohistochemical expression of epithelial and stromal immunomodulatory signalling molecules is a prognostic indicator in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22356547&form=6&db=m Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22370143&form=6&db=m Ameliorative effects of Diammonium Glycyrrhizinate on inflammation in focal cerebral ischemic-reperfusion injury. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22372762&form=6&db=m Prognostic value of apoptotic markers in squamous cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22373734&form=6&db=m Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22376259&form=6&db=m Linkage Disequilibrium and Haplotype Analysis of COX-2 and Risk of Colorectal Adenoma Development. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22378232&form=6&db=m Effects of silencing cyclooxygenase-2 expression via RNA interference on the tumorigenicity of the SMMC-7721 human hepatocarcinoma cell line. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22385256&form=6&db=m A Genetic Variant in 3'-Untranslated Region of Cyclooxygenases-2 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22386654&form=6&db=m Effects of polyphenol extract from olive pomace on anoxia-induced endothelial dysfunction. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22387750&form=6&db=m Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22389271&form=6&db=m Correlation between Spiral CT Preoperative Staging of Pancreatic Cancer and PTEN and COX-2 Expression. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22405334&form=6&db=m Fermentation by Lactobacillus enhances anti-inflammatory effect of Oyaksungisan on LPS-stimulated RAW 264.7 mouse macrophage cells. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22406826&form=6&db=m Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22411738&form=6&db=m Chemopreventive effects of NSAIDs as inhibitors of cyclooxygenase-2 and inducers of apoptosis in experimental lung carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22419920&form=6&db=m Cyclooxygenase-2 expression and its association with thyroid lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22425675&form=6&db=m Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22427843&form=6&db=m Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22429472&form=6&db=m Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22431150&form=6&db=m Suppressive Effect of Flavonoids from Korean Citrus aurantium L. on the Expression of Inflammatory Mediators in L6 Skeletal Muscle Cells. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22431924&form=6&db=m Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of Apc(Min/+) mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22438966&form=6&db=m Down-regulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22443108&form=6&db=m Antinociceptive and anti-inflammatory effects of electroacupuncture on experimental arthritis of the rat temporomandibular joint. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22446810&form=6&db=m CTB glycoprotein (75kDa) inhibits IgE releasing, TNF-? and IL-6 expressed by bisphenol A in vivo and in vitro. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460097&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in pituitary tumours. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460857&form=6&db=m Epithelial to mesenchymal transition in cutaneous squamous cell carcinoma is correlated with COX-2 expression but not with the presence of stromal macrophages or CD10-expressing cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22465818&form=6&db=m 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22468134&form=6&db=m Regulation of polyisoprenylated methylated protein methyl esterase by polyunsaturated fatty acids and prostaglandins. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22474519&form=6&db=m Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22483979&form=6&db=m Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22484495&form=6&db=m Tissue inhibitor of metalloproteinases in oral squamous cell carcinomas - a therapeutic target? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22502692&form=6&db=m Cyclooxygenase-2 expression is not a marker of poor survival in lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22505934&form=6&db=m Prostaglandins in cancer cell adhesion, migration, and invasion. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22523289&form=6&db=m Canine malignant mammary gland neoplasms with advanced clinical staging treated with carboplatin and cyclooxygenase inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22523380&form=6&db=m Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22527932&form=6&db=m Clinical relevance of cyclooxygenase-2 and matrix metalloproteinases (MMP-2 and MT1-MMP) in human breast cancer tissue. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534296&form=6&db=m Enhancement of anti-inflammatory activity of PEP-1-FK506 binding protein by silk fibroin peptide. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22535497&form=6&db=m Allopurinol ameliorates thioacetamide-induced acute liver failure by regulating cellular redox-sensitive transcription factors in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22544606&form=6&db=m ?-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22546756&form=6&db=m Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22547578&form=6&db=m Expression of COX-2 on Reed-Sternberg cells is an independent unfavorable prognostic factor in Hodgkin lymphoma treated with ABVD. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22549391&form=6&db=m Tumor interstitial fluid and gastric cancer metastasis: an experimental study to verify the hypothesis of "tumor-phlegm microenvironment". ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553068&form=6&db=m Anti-inflammatory effects of Amomum compactum on RAW 264.7 cells via induction of heme oxygenase-1. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22556201&form=6&db=m A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and ?-catenin transcriptional activity. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22558476&form=6&db=m Morphoproteomic confirmation of an activated nuclear factor-?Bp65 pathway in follicular thyroid carcinoma. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22560838&form=6&db=m Radiosynthesis of a ¹?F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22563252&form=6&db=m Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22570721&form=6&db=m Selection of metastatic breast cancer cells based on adaptability of their metabolic state. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22575501&form=6&db=m Heparanase and cyclooxygenase-2 gene and protein expressions during progression of oral epithelial dysplasia to carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22577245&form=6&db=m Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22577338&form=6&db=m COX-2 expression and tumor angiogenesis in thyroid carcinoma patients among northeast Chinese population-result of a single-center study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22580191&form=6&db=m Epigenetic deregulation of the COX pathway in cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22580984&form=6&db=m Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22582975&form=6&db=m The influence of transforming growth factor-?, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22595400&form=6&db=m Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22606284&form=6&db=m Radiation-induced c-Jun activation depends on MEK1-ERK1/2 signaling pathway in microglial cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22611435&form=6&db=m Regulation of Proinflammatory Mediators via NF-?B and p38 MAPK-Dependent Mechanisms in RAW 264.7 Macrophages by Polyphenol Components Isolated from Korea Lonicera japonica THUNB. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22617488&form=6&db=m Oligomers of ?-amyloid protein (A?1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1?, tumour necrosis factor-?, and a nuclear factor ?-B mechanism in the rat brain. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22617772&form=6&db=m A positive-margin resection model recreates the postsurgical tumor microenvironment and is a reliable model for adjuvant therapy evaluation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22632748&form=6&db=m Molecular Link Mechanisms between Inflammation and Cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22633646&form=6&db=m Immunohistochemical Expression of COX-2, mPGES and EP2 Receptor in Normal and Reactive Canine Bone and in Canine Osteosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22641101&form=6&db=m Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22644960&form=6&db=m Nonsteroidal anti-inflammatory drugs and the risk of skin cancer: A population-based case-control study. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22654456&form=6&db=m Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22658594&form=6&db=m Live imaging of tumor initiation in zebrafish larvae reveals a trophic role for leukocyte-derived PGE?. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22659375&form=6&db=m QSAR, docking and in vivo studies for immunomodulatory activity of isolated triterpenoids from Eucalyptus tereticornis and Gentiana kurroo. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22667343&form=6&db=m Immunohistochemical study of cyclooxygenase-2 in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22673539&form=6&db=m Expression of Ki67, BCL-2, and COX-2 in Canine Cutaneous Mast Cell Tumors: Association With Grading and Prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22676331&form=6&db=m Thromboxane Inhibitors Attenuate Inflammatory and Fibrotic Changes in Rat Liver Despite Continued Ethanol Administrations. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22678114&form=6&db=m Epithelial-mesenchymal transition increases tumor sensitivity to COX-2 inhibition by apricoxib. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22683859&form=6&db=m iNOS signaling interacts with COX-2 pathway in colonic fibroblasts. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22686557&form=6&db=m A Novel Cytotoxic T lymphocyte Epitope Analogue with Enhanced Activity Derived From Cyclooxygenase-2. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22687485&form=6&db=m Anti-tumor activity of the novel hexahydrocannabinol analog LYR-8 in Human colorectal tumor xenograft is mediated through the inhibition of Akt and hypoxia-inducible factor-1? activation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22687555&form=6&db=m Anti-glycative and anti-inflammatory effects of protocatechuic acid in brain of mice treated by d-galactose. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22687570&form=6&db=m Spirulina and C-phycocyanin reduce cytotoxicity and inflammation-related genes expression of microglial cells. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22687991&form=6&db=m Threshold dose of liver tumor promoting effect of ?-naphthoflavone in rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689176&form=6&db=m A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22696230&form=6&db=m Galectin-1 Promotes Lung Cancer Progression and Chemoresistance by Upregulating p38 MAPK, ERK, and Cyclooxygenase-2. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22703797&form=6&db=m Celecoxib inhibits invasion and metastasis via a cyclooxygenase 2-independent mechanism in an in vitro model of Ewing sarcoma. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22704420&form=6&db=m Effects of Feiyanning Decoction, a compound traditional Chinese medicine, on iNOS and COX-2 expressions induced by tumor necrosis factor-? in lung adenocarcinoma cell line. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22713176&form=6&db=m PPAR? delivered by Ch-GNPs onto titanium surfaces inhibits implant-induced inflammation and induces bone mineralization of MC-3T3E1 osteoblast-like cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22718198&form=6&db=m Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22729105&form=6&db=m Selective cyclooxygenase-2 inhibitor prevents cisplatin-induced tumorigenesis in A/J mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22729280&form=6&db=m Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22729746&form=6&db=m Prognostic significance of cyclooxygenase-2 in cervical cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22732221&form=6&db=m Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735610&form=6&db=m Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735861&form=6&db=m Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22745064&form=6&db=m Protective effects of HV-P411 complex against D-galactosamine-induced hepatotoxicity in rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22745074&form=6&db=m Anti-inflammatory effect of citrus unshiu peel in LPS-stimulated RAW 264.7 macrophage cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22750630&form=6&db=m Telmisartan treatment attenuates arsenic-induced hepatotoxicity in mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22751126&form=6&db=m p16(INK4A) Represses the paracrine tumor-promoting effects of breast stromal fibroblasts. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22752584&form=6&db=m Chemoprevention of Esophageal Squamous Cell Carcinoma with Berries. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22753587&form=6&db=m A new approach to reducing postsurgical cancer recurrence: perioperative targeting of catecholamines and prostaglandins. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22758658&form=6&db=m COX-2 mRNA is increased in oesophageal mucosal cells by a proton pump inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22760256&form=6&db=m The Anti-inflammatory Effect of Z-Ligustilide in Experimental Ovariectomized Osteopenic Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22761819&form=6&db=m Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22763881&form=6&db=m Overexpression of vasoactive intestinal peptide receptors and cyclooxygenase-2 in human prostate cancer. Analysis of potential prognostic relevance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22773136&form=6&db=m Gemfibrozil Pretreatment Affecting Antioxidant Defense System and Inflammatory, but not Nrf-2 Signaling Pathways Resulted in Female Neuroprotection and Male Neurotoxicity in the Rat Models of Global Cerebral Ischemia-Reperfusion. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22778026&form=6&db=m Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-?B activation, and inflammation-related gene expression. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22783382&form=6&db=m Predicting chemosensitivity in osteosarcoma prior to chemotherapy: An investigational study of biomarkers with immunohistochemistry. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22784710&form=6&db=m Cell Intrinsic Role of Cox-2 in Pancreatic Cancer Development. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22791816&form=6&db=m Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22797328&form=6&db=m Involvement of STAT3, NF-?B and associated downstream molecules before and after the onset of urethane induced lung tumors in mouse. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22797601&form=6&db=m Protein fraction of Calotropis procera latex protects against 5-fluorouracil-induced oral mucositis associated with downregulation of pivotal pro-inflammatory mediators. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22800939&form=6&db=m Tumor necrosis factor-alpha induces renal cyclooxygenase-2 expression in response to hypercalcemia. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22808264&form=6&db=m The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22809034&form=6&db=m Fermentation improves anti-inflammatory effect of sipjeondaebotang on LPS-stimulated RAW 264.7 cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22810591&form=6&db=m Addition of an induction regimen of antiangiogenesis and antitumor immunity to standard chemotherapy improves survival in advanced malignancies. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22814015&form=6&db=m Upregulation of intrinsic apoptotic pathway in NSAIDs mediated chemoprevention of experimental lung carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22819458&form=6&db=m Transketolase-like protein 1 expression in recurrent oral squamous cell carcinoma after curative resection: a case report. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22822908&form=6&db=m Antiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22824512&form=6&db=m Establishment and characterization of mouse bone marrow-derived mast cell hybridomas. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22825306&form=6&db=m Interleukin-18-induced inflammatory responses in synoviocytes and chondrocytes from osteoarthritic patients. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22828609&form=6&db=m Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22829202&form=6&db=m Apricoxib, a Novel Inhibitor of COX-2, Markedly Improves Standard Therapy Response in Molecularly Defined Models of Pancreatic Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22834139&form=6&db=m [COX-2 as an early diagnostic marker of virus-associated human malignant neoplasms]. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22843946&form=6&db=m Association Between COX-2 Expression and Effectiveness of COX-2 Inhibitors in a Phase II Trial in Patients with Metastatic Colorectal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22844559&form=6&db=m The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22844695&form=6&db=m Immunohistochemical evaluation of expression of heat shock proteins HSP70 and HSP90 in mammary gland neoplasms in bitches. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22850568&form=6&db=m Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22851770&form=6&db=m Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22855152&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in patients with advanced cancer of the larynx who have undergone induction chemotherapy with the intention of preserving phonation. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22864999&form=6&db=m Inhibitory Effects of Panduratin A on Allergy-Related Mediator Production in Rat Basophilic Leukemia Mast Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22868139&form=6&db=m Curcuma longa and Curcuma mangga leaves exhibit functional food property. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22868392&form=6&db=m Death-associated protein kinase 3 mediates vascular inflammation and development of hypertension in spontaneously hypertensive rats. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22870146&form=6&db=m Ductal adenocarcinoma of the pancreas: Expression of growth factor receptors, oncogenes and suppressor genes, and their relationship to pathological features, staging and survival. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22870593&form=6&db=m Role of immunohistochemical cyclo-oxygenase-2 (COX-2) and osteocalcin in differentiating between osteoblastomas and osteosarcomas. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22871521&form=6&db=m Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22884582&form=6&db=m IL1?-mediated Stromal COX-2 signaling mediates proliferation and invasiveness of colonic epithelial cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22885178&form=6&db=m Stromal COX-2 signaling activated by deoxycholic acid mediates proliferation and invasiveness of colorectal epithelial cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22887904&form=6&db=m Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22893198&form=6&db=m Mechanistic Aspects of COX-2 Expression in Colorectal Neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22893199&form=6&db=m Mode of action of aspirin as a chemopreventive agent. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22893202&form=6&db=m New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22898172&form=6&db=m Pulmotoxicological effects caused by long-term titanium dioxide nanoparticles exposure in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22902545&form=6&db=m Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22902988&form=6&db=m Differential hepatoprotective mechanisms of rutin and quercetin in CCl(4)-intoxicated BALB/cN mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22904679&form=6&db=m Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22910095&form=6&db=m The connection between lymphangiogenic signalling and prostglandin biology: A missing link in the metastatsic pathway. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22919383&form=6&db=m Potential anticancer properties of grape antioxidants. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22922217&form=6&db=m Exposure of Wistar rats to 24-h psycho-social stress alters gene expression in the inferior colliculus. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22922684&form=6&db=m The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22925934&form=6&db=m Expression of the aryl hydrocarbon receptor pathway and cyclooxygenase-2 in dog tumors. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22928837&form=6&db=m Pistacia chinensis Inhibits NO Production and Upregulates HO-1 Induction via PI-3K/Akt Pathway in LPS Stimulated Macrophage Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22936450&form=6&db=m Expression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impact. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22937980&form=6&db=m Low-level laser therapy and sodium diclofenac in acute inflammatory response induced by skeletal muscle trauma: Effects in muscle morphology and mRNA gene expression of inflammatory markers. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22940184&form=6&db=m Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-?B, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22940262&form=6&db=m Therapeutic role of telmisartan against acetaminophen hepatotoxicity in mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22940705&form=6&db=m COX inhibitors Indomethacin and Sulindac derivatives as antiproliferative agents: Synthesis, biological evaluation, and mechanism investigation. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22950494&form=6&db=m Chemoprevention of Cancers in Gastrointestinal Tract with Cyclooxygenase 2 Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22950507&form=6&db=m Nicotine and Gastrointestinal Disorders: Its Role in Ulceration and Cancer Development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22954186&form=6&db=m In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22959056&form=6&db=m Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22961879&form=6&db=m Concomitant consumption of lycopene and fish oil inhibits tumor growth and progression in a mouse xenograft model of colon cancer. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22963993&form=6&db=m Akebia Saponin D attenuates amyloid ?-induced cognitive deficits and inflammatory response in rats: Involvement of Akt/NF-?B pathway. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971613&form=6&db=m 1,25-Dihydroxyvitamin D3 inhibits growth of the breast cancer cell line MCF-7 and downregulates cytochrome P4501B1 through the COX-2/PGE2 pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971618&form=6&db=m Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22971811&form=6&db=m Interrelationship and expression profiling of cyclooxygenase and angiogenic factors in Indian patients with multiple myeloma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22972613&form=6&db=m Antipyretic and Anti-inflammatory Effects of Asiaticoside in Lipopolysaccharide-treated Rat through Up-regulation of Heme Oxygenase-1. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22975511&form=6&db=m Hepatoprotective Effects of the Polysaccharide Isolated from Tarphochlamys affinis (Acanthaceae) against CCl(4)-Induced Hepatic Injury. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22975730&form=6&db=m S632A3, a new glutarimide antibiotic, suppresses lipopolysaccharide-induced pro-inflammatory responses via inhibiting the activation of glycogen synthase kinase 3? causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22981803&form=6&db=m Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993369&form=6&db=m Cyclooxygenase-2 (COX-2) up-regulation is a prognostic marker for poor clinical outcome of upper tract urothelial cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993537&form=6&db=m The use of Cox-2 and PPAR? signaling in anti-cancer therapies. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993597&form=6&db=m Inhibition of tumor angiogenesis by oral etoposide. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22998139&form=6&db=m Radiation-induced neuroinflammation and radiation somnolence syndrome. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22999851&form=6&db=m Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23001726&form=6&db=m The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23007878&form=6&db=m Biglycan expression and clinical outcome in patients with pancreatic adenocarcinoma. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23008118&form=6&db=m Chemopreventive efficacy of green tea drinking against 1,2-dimethyl hydrazine-induced rat colon carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23013439&form=6&db=m Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23013454&form=6&db=m Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23022187&form=6&db=m The anti-inflammatory effects of ethyl acetate on Lipopolysaccharide/D-galactosamine challenged mice and Lipopolysaccharide activated RAW264.7 cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23024755&form=6&db=m Dietary administration of scallion extract effectively inhibits colorectal tumor growth: cellular and molecular mechanisms in mice. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23025331&form=6&db=m Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23026982&form=6&db=m Celecoxib desensitization: continued temozolomide/celecoxib chemotherapy after a celecoxib-induced hypersensitivity reaction. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23029430&form=6&db=m Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23029551&form=6&db=m Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23031678&form=6&db=m Tissue biomarkers as prognostic variables of cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23037997&form=6&db=m Nephrotoxic effect of subchronic exposure to S-(1,2-dichlorovinyl)-L-cysteine in mice. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23038005&form=6&db=m Enhanced liver tumor promotion but not liver initiation activity in rats subjected to combined administration of omeprazole and ?-naphthoflavone. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23052170&form=6&db=m Heterogeneity of COX-2 and multidrug resistance between primary tumors and regional lymph node metastases of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23053397&form=6&db=m The role of PGE2-associated inflammatory responses in gastric cancer development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23055213&form=6&db=m Induction of prosurvival molecules during treatment: rethinking therapy options for photodynamic therapy. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23063604&form=6&db=m Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23089186&form=6&db=m Age dependent increase in prostaglandin pathway coincides with onset of ovarian cancer in laying hens. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23092161&form=6&db=m Anti-Cancer Effects of a New Docosahexaenoic Acid Monoacylglyceride in Lung Adenocarcinoma. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23097685&form=6&db=m The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23098208&form=6&db=m p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23105117&form=6&db=m Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23109673&form=6&db=m Effect of sphingosine kinase 1 inhibition on blood pressure. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23109979&form=6&db=m Detection of Survivin and COX-2 in Thyroid Carcinoma: Anaplastic Carcinoma Shows Overexpression of Nuclear Survivin and Low COX-2 Expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23112250&form=6&db=m Simultaneous targeting of COX-2 and AKT using selenocoxib-1-GSH to inhibit melanoma. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23115597&form=6&db=m Virtual Screening for Finding Novel COX-2 Inhibitors as Antitumor Agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23116643&form=6&db=m Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23117134&form=6&db=m Effects of caffeine on sperm characteristics after thawing and inflammatory response in the uterus after artificial insemination with frozen-thawed boar semen. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23117797&form=6&db=m Single-dose safety and pharmacokinetic evaluation of fluorocoxib A: pilot study of novel cyclooxygenase-2-targeted optical imaging agent in a canine model. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23122366&form=6&db=m Intestinal-type sinonasal adenocarcinomas. Immunohistochemical profile of 66 cases. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23125227&form=6&db=m Preventative topical diclofenac treatment differentially decreases tumor burden in male and female Skh-1 mice in a model of UVB-induced cutaneous squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23128312&form=6&db=m Anti-inflammatory effects of egg white combined with chalcanthite in lipopolysaccharide-stimulated BV2 microglia through the inhibition of NF-?B, MAPK and PI3K/Akt signaling pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23137061&form=6&db=m Chronic Exposure of Renal Stem Cells to Inorganic Arsenic Induces a Cancer Phenotype. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23137186&form=6&db=m 2-Hydroxyethyl methacrylate inflammatory effects in human gingival fibroblasts. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23141895&form=6&db=m Chemoprevention of colorectal cancer with ursodeoxycholic acid: pro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23142242&form=6&db=m Therapeutic potential of monoacylglycerol lipase inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23147509&form=6&db=m Post-insult ibuprofen treatment attenuates damage to the serotonergic system after hypoxia-ischemia in the immature rat brain. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23150665&form=6&db=m Cyclooxygenase-2 induces the expression of the alpha 2,3 sialyltransferase-3 (ST3Gal-I) in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23155226&form=6&db=m Biomarkers of pituitary neoplasms. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23159484&form=6&db=m Quinolines: a new hope against inflammation. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23161610&form=6&db=m Src kinase is a direct target of apigenin against UVB-induced skin inflammation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23166763&form=6&db=m Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23167360&form=6&db=m Tanshinone II--a inhibits angiogenesis through down regulation of COX-2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23169309&form=6&db=m Overview of molecular pathways in inflammatory bowel disease associated with colorectal cancer development. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23172667&form=6&db=m Ochratoxin A-induced cell proliferation and tumor promotion in mouse skin by activating the expression of cyclin-D1 and cyclooxygenase-2 through nuclear factor-kappa B and activator protein-1. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23172668&form=6&db=m Selective Cox-2 inhibitor celecoxib induces epithelial-mesenchymal transition in human lung cancer cells via activating MEK-ERK signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23172681&form=6&db=m Attenuation of NDEA-induced hepatocarcinogenesis by naringenin in rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23175425&form=6&db=m Inhibitory effects of Akebia quinata ethanol extract on TNF-?-mediated vascular inflammation in human aortic smooth muscle cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23177619&form=6&db=m Correlation analysis of c-myc, p21(WAF/CIP1), p53, C-erbB-2 and COX-2 proteins in esophageal squamous cell carcinoma. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23180004&form=6&db=m Immunohistochemical molecular expression profile of metastatic brain tumor for potent personalized medicine. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23185700&form=6&db=m Cyclooxygenase and prostaglandin in cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23192657&form=6&db=m Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23193911&form=6&db=m Antitumor properties of taxol in combination with cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian tumor growth in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23194884&form=6&db=m Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23200247&form=6&db=m Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23201441&form=6&db=m Effect of body-weight loading onto the articular cartilage on the occurrence of quinolone-induced chondrotoxicity in juvenile rats. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23205124&form=6&db=m Effects of cyclooxygenase inhibitors on survival time in ovarian cancer xenograft-bearing mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23220159&form=6&db=m Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23220503&form=6&db=m COX-2 and PPAR-? confer cannabidiol-induced apoptosis of human lung cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23220964&form=6&db=m S-layer protein mediates the stimulatory effect of Lactobacillus helveticus MIMLh5 on innate immunity. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23221733&form=6&db=m COX-2 expression and survival in patients with locally advanced cervical cancer treated with chemoradiotherapy and celecoxib: a quantitative immunohistochemical analysis of RTOG C0128. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226427&form=6&db=m Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23226798&form=6&db=m Antitumor effect of the selective COX-2 inhibitor celecoxib on endometrial adenocarcinoma in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23241116&form=6&db=m Eicosapentaenoic acid modulates CyA-induced proinflammatory cytokine over-expression in osteoblastic cells in vitro. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23246159&form=6&db=m ?-Tocotrienol inhibits lipopolysaccharide-induced interlukin-6 and granulocyte colony-stimulating factor by suppressing C/EBP? and NF-?B in macrophages. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23250387&form=6&db=m Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23251109&form=6&db=m The effects of piroxicam and deracoxib on canine mammary tumour cell line. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23260331&form=6&db=m Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23261444&form=6&db=m The transcription factor Snail expressed in cutaneous squamous cell carcinoma induces epithelial-mesenchymal transition and down-regulates COX-2. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23261679&form=6&db=m Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-?B inactivation. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23268707&form=6&db=m Different cell cycle modulation by celecoxib at different concentrations. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23272114&form=6&db=m Effects of enriched environment on COX-2, leptin and eicosanoids in a mouse model of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23274131&form=6&db=m Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23275522&form=6&db=m Cyclooxygenase-2 enzyme induces the expression of the ?-2,3-sialyltransferase-3 (ST3Gal-I) in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23280445&form=6&db=m Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23289871&form=6&db=m Inhibition of COX-2 expression by topical diclofenac enhanced radiation sensitivity via enhancement of TRAIL in human prostate adenocarcinoma xenograft model. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23291066&form=6&db=m [Inhibitory effect of nimesulide and oxaliplatin on tumor growth and lymphatic metastasis of transplanted human lung cancer in nude mice]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23293573&form=6&db=m Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23305935&form=6&db=m Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23307260&form=6&db=m Reduced group IVA phospholipase A2 expression is associated with unfavorable outcome for patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23318418&form=6&db=m Constitutive TLR4 signalling in intestinal epithelium reduces tumor load by increasing apoptosis in APC(Min/+) mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23320030&form=6&db=m Bridelia ferruginea Produces Antineuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23322198&form=6&db=m Cox-2 inhibition enhances the activity of sunitinib in human renal cell carcinoma xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23326291&form=6&db=m Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23333629&form=6&db=m Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23336375&form=6&db=m [Expression of hypoxia-inducible factor 1? in osteosarcoma and its value in predicting chemosensitivity]. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23343963&form=6&db=m Cyclooxygenase, cancer stem cells and DNA methylation play important roles in colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23346542&form=6&db=m Prognostic implications of tumor volume response and COX-2 expression change during radiotherapy in cervical cancer patients. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23347845&form=6&db=m Increase of cyclooxygenase-2 inhibition with celecoxib combined with 5-FU enhances tumor cell apoptosis and antitumor efficacy in a subcutaneous implantation tumor model of human colon cancer. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349017&form=6&db=m LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349335&form=6&db=m Positional isomers of aspirin are equally potent in inhibiting colon cancer cell growth: differences in mode of cyclooxygenase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23353741&form=6&db=m Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357584&form=6&db=m Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptoticeffect. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23359084&form=6&db=m Functional Food Quality of Curcuma caesia, Curcuma zedoaria and Curcuma aeruginosa Endemic to Northeastern India. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23359190&form=6&db=m Impact of COX-2, IL-1?, TNF-?, IL-4 and IL-10 on the process of carcinogenesisin the large bowel. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23365670&form=6&db=m Green tea phenolic epicatechins inhibit hepatitis C virus replication via cycloxygenase-2 and attenuate virus-induced inflammation. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370197&form=6&db=m Synthesis and biological evaluation of new heteroaryl carboxylic acid derivatives as anti-inflammatory-analgesic agents. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23370667&form=6&db=m Anti-neuroinflammatory activity of a novel cannabinoid derivative by inhibiting the NF-?B signaling pathway in lipopolysaccharide-induced BV-2 microglial cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23371504&form=6&db=m Anticancer activity of fish oils against human lung cancer is associated with changes in formation of PGE(2) and PGE(3) and Alteration of Akt Phosphorylation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23371749&form=6&db=m Intra-hippocampal injection of lipopolysaccharide inhibits kindled seizures and retards kindling rate in adult rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23375200&form=6&db=m Lapatinib inhibits meiotic maturation of porcine oocyte-cumulus complexes cultured in vitro in gonadotropin-supplemented medium. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376120&form=6&db=m Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-?B and MAPKs activation via the phosphatidylinositol 3-kinase signaling. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376181&form=6&db=m Water extract of processed Hydrangea macrophylla (Thunb.) Ser. leaf attenuates the expression of pro-inflammatory mediators by suppressing Akt-mediated NF-?B activation. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384501&form=6&db=m Cox-2 in non-small cell lung cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384791&form=6&db=m [(123)I]Iodooctyl fenbufen amide as a SPECT tracer for imaging tumors that over-express COX enzymes. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23385883&form=6&db=m Celecoxib enhances the efficacy of 15-hydroxyprostaglandin dehydrogenase gene therapy in treating murine breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23394447&form=6&db=m Change in nicotine-induced VEGF, PGE2 AND COX-2 expression following COX inhibition in human oral squamous cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23394584&form=6&db=m Oligonol Inhibits Dextran Sulfate Sodium-induced Colitis and Colonic Adenoma Formation in Mice. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23396144&form=6&db=m Protective effect of Codium fragile against UVB-induced pro-inflammatory and oxidative damages in HaCaT cells and BALB/c mice. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401564&form=6&db=m Early methyl donor deficiency produces severe gastritis in mothers and offspring through N-homocysteinylation of cytoskeleton proteins, cellular stress, and inflammation. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401648&form=6&db=m Endomicroscopic Imaging of COX-2 Activity in Murine Sporadic and Colitis-Associated Colorectal Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23409048&form=6&db=m Cyclooxgenase-2 inhibiting perfluoropoly (ethylene glycol) ether theranostic nanoemulsions-in vitro study. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23422504&form=6&db=m Prognostic role of cyclooxygenase-2 in epithelial ovarian cancer: A meta-analysis of observational studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426606&form=6&db=m Correlation among 16 biological factors [p53, p21(waf1), MIB-1 (Ki-67), p16(INK4A), cyclin D1, E-cadherin, Bcl-2, TNF-?, NF-?B, TGF-?, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1?] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426790&form=6&db=m Anti-inflammatory effects of total alkaloids from Rubus aleaefolius Poir. on non-alcoholic fatty liver disease through regulation of the NF-?B pathway. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23427297&form=6&db=m Tandutinib inhibits the Akt/mTOR signaling pathway to inhibit colon cancer growth. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23431240&form=6&db=m Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23435965&form=6&db=m Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23443799&form=6&db=m A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23444045&form=6&db=m Association between a functional variant at PTGS2 gene 3'UTR and its mRNA expression in lymphoblastoid cell lines. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23448776&form=6&db=m Successful treatment of an unresectable inflammatory myofibroblastic tumor of the frontal bone using a cyclooxygenase-2 inhibitor and methotrexate. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23452119&form=6&db=m Combination of Celecoxib and Doxorubicin Increases the Growth Inhibition and Apoptosis in Acute Myeloid Leukemia Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23454824&form=6&db=m Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23456767&form=6&db=m Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23463959&form=6&db=m Serum adipocyte fatty acid-binding protein in the critically ill. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23466568&form=6&db=m Inhibition of Signal Transducer and Activator of Transcription 3 and Cyclooxygenase-2 Is Involved in Radiosensitization of Cepharanthine in HeLa Cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23469054&form=6&db=m Aqueous Extract of the Edible Gracilaria tenuistipitata Inhibits Hepatitis C Viral Replication via Cyclooxygenase-2 Suppression and Reduces Virus-Induced Inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23469860&form=6&db=m P2X7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23479369&form=6&db=m Smoking and Colorectal Cancer Risk by Tumor Genetic and Epigenetic Subtypes: A Molecular Pathological Epidemiology (MPE) Study. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23479371&form=6&db=m Physical Activity, Tumor PTGS2 Expression, and Colorectal Cancer Survival: A Molecular Pathological Epidemiology (MPE) Approach. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23482441&form=6&db=m A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23488616&form=6&db=m Design, Synthesis, and Structure-Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase-2 as Targeted Optical Imaging Agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23489848&form=6&db=m Different role of COX-2 and angiogenesis in canine inflammatory and non-inflammatory mammary cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23494177&form=6&db=m The association between cyclooxygenase-2 1195 G/A polymorphism and hepatocellular carcinoma: evidence from a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23494519&form=6&db=m Inhibitory effects of sigma-2 receptor agonists on T lymphocyte activation. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23506529&form=6&db=m Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23513960&form=6&db=m Method development and validation for ultra-high pressure liquid chromatography/tandem mass spectrometry determination of multiple prostanoids in biological samples. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23514809&form=6&db=m Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: early target in the anticancer strategy. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23515290&form=6&db=m TGF-? Effects on Prostate Cancer Cell Migration and Invasion Are Mediated by PGE2 through Activation of PI3K/AKT/mTOR Pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23516604&form=6&db=m High Expression of HuR in Cytoplasm, but Not Nuclei, Is Associated with Malignant Aggressiveness and Prognosis in Bladder Cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23517721&form=6&db=m Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23520664&form=6&db=m Can cyclo-oxygenase-2 be a useful prognostic and risk stratification marker in breast cancer? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23527044&form=6&db=m Prognostic Significance of COX-2 Immunohistochemical Expression in Colorectal Cancer: A Meta-Analysis of the Literature. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23531445&form=6&db=m Molecular Imaging of Cyclooxygenase-2 in Canine Transitional Cell Carcinomas In Vitro and In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23533508&form=6&db=m Inhibitory effects of traditional herbal formula pyungwi-san on inflammatory response in vitro and in vivo. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23533584&form=6&db=m Effects of C-phycocyanin and Spirulina on Salicylate-Induced Tinnitus, Expression of NMDA Receptor and Inflammatory Genes. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23536473&form=6&db=m Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23552749&form=6&db=m [Expression and function of E prostanoid receptors in urological cancer]. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23566419&form=6&db=m A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in primary breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23579438&form=6&db=m COX-2 in cancer: Gordian knot or Achilles heel? causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23580446&form=6&db=m Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23597450&form=6&db=m Anti-inflammatory effect of prunetin via the suppression of NF-?B pathway. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23604881&form=6&db=m The effect of lipopolysaccharide on enhanced inflammatory process with age: Modulation of NF-?B. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23608225&form=6&db=m miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF). causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23617728&form=6&db=m Papillary Carcinoma of the Thyroid: High Expression of COX-2 and Low Expression of KAI-1/CD82 Are Associated with Increased Tumor Invasiveness. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23619259&form=6&db=m The effect of celecoxib on the development of diethylnitrosamine-induced liver tumors in rats. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23619528&form=6&db=m Multilevel pharmacological manipulation of adenosine-prostaglandin E?/cAMP nexus in the tumor microenvironment: a 'two hit' therapeutic opportunity. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23619720&form=6&db=m Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23620247&form=6&db=m Hepatoprotective effect of the flavonoid fraction isolated from the flower of Inula britannica against D-Galactosamine-induced hepatic injury. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23620771&form=6&db=m The association between COX-2 polymorphisms and hematologic toxicity in patients with advanced non-small-cell lung cancer treated with platinum-based chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625281&form=6&db=m Expression of estrogen receptors (?, ?), cyclooxygenase-2 and aromatase in normal endometrium and endometrioid cancer of uterus. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625311&form=6&db=m Licochalcone E present in licorice suppresses lung metastasis in the 4T1 mammary orthotopic cancer model. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625729&form=6&db=m Simvastatin treatment ameliorates injury of rat testes induced by cadmium toxicity. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23629521&form=6&db=m Physical activity, tumor PTGS2 expression, and survival in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23640055&form=6&db=m Nuclear monomeric integrin ?v in cancer cells is a coactivator regulated by thyroid hormone. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23645839&form=6&db=m AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/?-catenin signaling pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23651067&form=6&db=m Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23658799&form=6&db=m Fatty acid metabolites in rapidly proliferating breast cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23667623&form=6&db=m Cyclooxygenase-2 inhibition blocks M2 macrophage differentiation and suppresses metastasis in murine breast cancer model. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23668350&form=6&db=m Structural modeling and simulation studies of human cyclooxygenase (COX) isozymes with selected terpenes: implications in drug designing and development. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23669730&form=6&db=m Successful treatment of recurrent pediatric inflammatory myofibroblastic tumor in a single patient with a novel chemotherapeutic regimen containing celecoxib. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23670240&form=6&db=m COX-2 regulates E-cadherin expression through the NF-?B/Snail signaling pathway in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23673480&form=6&db=m Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675067&form=6&db=m Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23677863&form=6&db=m Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23678395&form=6&db=m Chemoprevention of Colon Cancer by iNOS-Selective Inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23679681&form=6&db=m Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting Survivin and XIAP. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23679684&form=6&db=m Effects of celecoxib treatment over the AKT pathway in head and neck squamous cell carcinoma. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23681187&form=6&db=m Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23690221&form=6&db=m Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23700916&form=6&db=m Plant-derived anticancer agents - curcumin in cancer prevention and treatment. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23704815&form=6&db=m Hepatoprotective effect of polysaccharides from Boschniakia rossica on carbon tetrachloride-induced toxicity in mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23707774&form=6&db=m Fluoride-elicited developmental testicular toxicity in rats: Roles of endoplasmic reticulum stress and inflammatory response. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23707983&form=6&db=m Effects of low-frequency ultrasound and microbubbles on angiogenesis-associated proteins in subcutaneous tumors of nude mice. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23708096&form=6&db=m Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717106&form=6&db=m Protective Effect of Processed Panax ginseng, Sun Ginseng on UVB-irradiated Human Skin Keratinocyte and Human Dermal Fibroblast. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23717604&form=6&db=m Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23728342&form=6&db=m Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via ?9?1 integrin. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23731018&form=6&db=m Stilbenes and Anthocyanins Reduce Stress Signaling in BV-2 Mouse Microglia. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23737649&form=6&db=m Protective effect of short-term genistein supplementation on the early stage in diabetes-induced renal damage. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23737876&form=6&db=m Saikosaponin A mediates the inflammatory response by inhibiting the MAPK and NF-?B pathways in LPS-stimulated RAW 264.7 cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23739309&form=6&db=m Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23740407&form=6&db=m Lipopolysaccharide (LPS) promotes osteoclast differentiation and activation by enhancing the MAPK pathway and COX-2 expression in RAW264.7 cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23741059&form=6&db=m Epithelial-Specific Deletion of 11?-HSD2 Hinders Apcmin/+ Mouse Tumorigenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23742256&form=6&db=m Mitochondria protection with ginkgolide B-loaded polymeric nanocapsules prevents diethylnitrosamine-induced hepatocarcinoma in rats. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23743684&form=6&db=m Late administration of a specific COX-2 inhibitor does not treat and/or prevent progression of gastric tumors in rats submitted to duodenogastric reflux procedure. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23756166&form=6&db=m Regulatory T cells in cancer: an overview and perspectives on cyclooxygenase-2 and Foxp3 DNA methylation. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23760031&form=6&db=m Radiolabeled COX-2 inhibitors for non-invasive visualization of COX-2 expression and activity--a critical update. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23764465&form=6&db=m Rhododendrin ameliorates skin inflammation through inhibition of NF-?B, MAPK, and PI3K/Akt signaling. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23770416&form=6&db=m Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23771412&form=6&db=m The selective 5-LOX inhibitor 11-keto-?-boswellic acid protects against myocardial ischemia reperfusion injury in rats: involvement of redox and inflammatory cascades. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23774942&form=6&db=m A soft coral natural product, 11-episinulariolide acetate, inhibits gene expression of cyclooxygenase-2 and interleukin-8 through attenuation of calcium signaling. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23775504&form=6&db=m Olmesartan decreases IL-1? and TNF-? levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23782142&form=6&db=m New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23783392&form=6&db=m Cyclooxygenase-2 utilizes Jun N-terminal kinases to induce invasion, but not tamoxifen resistance, in MCF-7 breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23783459&form=6&db=m Natural products as a source of anti-inflammatory agents associated with inflammatory bowel disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23792896&form=6&db=m Monoterpenoid indole alkaloids from Alstonia rupestris with cytotoxic, anti-inflammatory and antifungal activities. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23797659&form=6&db=m Achillea millefolium L. Essential Oil Inhibits LPS-Induced Oxidative Stress and Nitric Oxide Production in RAW 264.7 Macrophages. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23800958&form=6&db=m Regulation of Innate Immune Function in Bovine Oviduct Epithelial Cells in Culture: The Homeostatic Role of Epithelial Cells in Balancing Th1/Th2 Response. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23801169&form=6&db=m Clinical significance of VEGFR-2 and (18)F-FDG PET/CT SUVmax pretreatment score in predicting the long-term outcome of patients with locally advanced rectal cancer treated with neoadjuvant therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23802065&form=6&db=m COX2 regulation of breast cancer bone metastasis. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23810915&form=6&db=m PTGS2 (Cyclooxygenase-2) Expression and Survival among Colorectal Cancer Patients: A Systematic Review. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23812214&form=6&db=m Inhibitory effects of tocopherols on expression of the cyclooxygenase-2 gene in RAW264.7 cells stimulated by lipopolysaccharide, tumor necrosis factor-? or Porphyromonas gingivalis fimbriae. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23818450&form=6&db=m Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23831355&form=6&db=m A novel glucosamine derivative exerts anti-inflammatory actions via inhibition of nuclear factor-kappaB. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23831470&form=6&db=m Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23833643&form=6&db=m CD44(+) gastric cancer cells with stemness properties are chemoradioresistant and highly invasive. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23834160&form=6&db=m Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23834173&form=6&db=m Targeting Proteasomal Pathways by Dietary Curcumin for Cancer Prevention and Treatment. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23840248&form=6&db=m AP-1/IRF-3 Targeted Anti-Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851330&form=6&db=m Prognostic significance of COX-2 expression and correlation with Bcl-2 and VEGF expression, microvessel density, and clinical variables in classical Hodgkin lymphoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852449&form=6&db=m Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23857285&form=6&db=m Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23862760&form=6&db=m An off-on COX-2-specific fluorescent probe: targeting the Golgi apparatus of cancer cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23864034&form=6&db=m Ethanol extract of Cnidium officinale exhibits anti-inflammatory effects in BV2 microglial cells by suppressing NF-?B nuclear translocation and the activation of the PI3K/Akt signaling pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23869759&form=6&db=m TNF?-activated stromal COX-2 signalling promotes proliferative and invasive potential of colon cancer epithelial cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23871788&form=6&db=m Artocarpin attenuates ultraviolet B-induced skin damage in hairless mice by antioxidant and anti-inflammatory effect. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23875171&form=6&db=m COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23877027&form=6&db=m Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23878744&form=6&db=m The epidermal growth factor receptor increases cytokine production and cutaneous inflammation in response to ultraviolet irradiation. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23886173&form=6&db=m Overexpression of cyclooxygenase-1 correlates with poor prognosis in renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23886206&form=6&db=m Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators-(TNF-a, iNOS, COX-2, IL-1?, IL-6, IFN-?, IL-2, GM-CSF) and pro-angiogenic growth factor- VEGF. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23887648&form=6&db=m Anti-inflammatory activity of N-(3-florophenyl)ethylcaffeamide in mice. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23890358&form=6&db=m Anti-inflammatory and carbonic anhydrase restoring actions of yam powder (Dioscorea spp) contribute to the prevention of cysteamine-induced duodenal ulcer in a rat model. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23893925&form=6&db=m The role of thiamine in cancer: possible genetic and cellular signaling mechanisms. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23897985&form=6&db=m Nitrogen Dioxide and Ultrafine Particles Dominate the Biological Effects of Inhaled Diesel Exhaust Treated by a Catalyzed Diesel Particulate Filter. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23901209&form=6&db=m UP446, analgesic and anti-inflammatory botanical composition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23904362&form=6&db=m Salidroside attenuates LPS-stimulated activation of THP-1 cell-derived macrophages through down-regulation of MAPK/NF-kB signaling pathways. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23905422&form=6&db=m [The role of TLR4 receptor in development of inflammation and carcinogenesis in ulcerative colitis and pharmacotherapy of this disorder]. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23905928&form=6&db=m Cycloxygenase-2 (COX-2)--a potential target for screening of small molecules as radiation countermeasure agents: an in silico study. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23911884&form=6&db=m Ruscogenin reduces cerebral ischemic injury via NF-?B-mediated inflammatory pathway in the mouse model of experimental stroke. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23916228&form=6&db=m Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1? in human immune cells via oxidative stress. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23918793&form=6&db=m The invisible arm of immunity in common cancer chemoprevention agents. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23924857&form=6&db=m Oldhamianoside II, a new triterpenoid saponin, prevents tumor growth via inducing cell apoptosis and inhibiting angiogenesis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23925459&form=6&db=m Pharmacological characterization of Solanum cernuum Vell.: 31-norcycloartanones with analgesic and anti-inflammatory properties. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23927563&form=6&db=m Role of Interleukin-1? in Radiation-Enhancement of MDA-MB-231 Breast Cancer Cell Invasion. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23928829&form=6&db=m Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23932824&form=6&db=m Anti-proliferative effects of a new docosapentaenoic acid monoacylglyceride in colorectal carcinoma cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23934545&form=6&db=m Loss of PPAR? expression in mammary secretory epithelial cells creates a pro-breast tumorigenic environment. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23935680&form=6&db=m Sargassum fulvellum Protects HaCaT Cells and BALB/c Mice from UVB-Induced Proinflammatory Responses. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23936870&form=6&db=m 11?-Hydroxysteroid Dehydrogenase Type II is a Potential Target for Prevention of Colorectal Tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23943857&form=6&db=m INDUCTION BUT NOT INHIBITION OF COX-2 CONFERS HUMAN LUNG CANCER CELL APOPTOSIS BY CELECOXIB. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23946495&form=6&db=m Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23946685&form=6&db=m Curcumin attenuates radiation-induced inflammation and fibrosis in rat lungs. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23955549&form=6&db=m Expressions of ER, PR, HER-2, COX-2, and VEGF in Primary and Relapsed/Metastatic Breast Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23958744&form=6&db=m Molecular Pathways: Adipose Inflammation as a Mediator of Obesity-Associated Cancer. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23967159&form=6&db=m A Meta-Analysis of PTGS1 and PTGS2 Polymorphisms and NSAID Intake on the Risk of Developing Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973710&form=6&db=m miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973990&form=6&db=m Cyclooxygenase-2 (COX-2) Inhibition Constrains Indoleamine 2,3-Dioxygenase 1 (IDO1) Activity in Acute Myeloid Leukaemia Cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23975340&form=6&db=m Cyclooxygenase-2 Promotes Hepatocellular Apoptosis by Interacting with TNF-? and IL-6 in the Pathogenesis of Nonalcoholic Steatohepatitis in Rats. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23977892&form=6&db=m In vitro effects of meloxicam on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23983093&form=6&db=m The preventive role of breadfruit against inflammation-associated epithelial carcinogenesis in mice. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23992308&form=6&db=m Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of e-cadherin in pancreatic cancer cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23993482&form=6&db=m Protective effect of cannabidiol against cadmium hepatotoxicity in rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23997259&form=6&db=m Doxorubicin and deracoxib adjuvant therapy for canine splenic hemangiosarcoma: A pilot study. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24000661&form=6&db=m [Coxibs for postoperative analgesia]. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24002607&form=6&db=m Pre-irradiation of mouse mammary gland stimulates cancer cell migration and development of lung metastases. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24004819&form=6&db=m Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24005609&form=6&db=m Fish Oil Alleviates Activation of Hypothalamic-Pituitary-Adrenal Axis Associated with Inhibition of TLR4 and NOD Signaling Pathways in Weaned Piglets after a Lipopolysaccharide Challenge. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24008428&form=6&db=m Pharmacology of Cannabinoid Receptor Agonists and a Cyclooxygenase-2 Inhibitor in Rat Bone Tumor Pain. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019861&form=6&db=m Expression of COX-2, CD44v6 and CD147 and Relationship with Invasion and Lymph Node Metastasis in Hypopharyngeal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24023834&form=6&db=m COX-2-765G>C Polymorphism Increases the Risk of Cancer: A Meta-Analysis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24025609&form=6&db=m Triggering of suicidal erythrocyte death by celecoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24025684&form=6&db=m Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24036940&form=6&db=m Tumor growth reduction is regulated at the gene level in Walker 256 tumor-bearing rats supplemented with fish oil rich in EPA and DHA. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24040391&form=6&db=m The Anti-Tumor Effect of HDAC Inhibition in a Human Pancreas Cancer Model Is Significantly Improved by the Simultaneous Inhibition of Cyclooxygenase 2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24048323&form=6&db=m Immunohistochemical Vascular Factor Expression in Canine Inflammatory Mammary Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24055519&form=6&db=m Sesquiterpene dimer (DSF-52) from Artemisia argyi inhibits microglia-mediated neuroinflammation via suppression of NF-?B, JNK/p38 MAPKs and Jak2/Stat3 signaling pathways. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24056124&form=6&db=m Tunicamycin inhibits Toll-like receptor-activated inflammation in RAW264.7 cells by suppression of NF-?B and c-Jun activity via a mechanism that is independent of ER-stress and N-glycosylation. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24057882&form=6&db=m Alteration in apoptosis and cell cycle by celecoxib and/or fish oil in 7,12-dimethyl benzene (?) anthracene-induced mammary carcinogenesis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059237&form=6&db=m Radiotracers for Molecular Imaging of Cyclooxygenase-2 (COX-2) Enzyme. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24060154&form=6&db=m Concurrent Expression of Cyclo-oxygenase-2 and Epidermal Growth Factor Receptor in Canine Malignant Mammary Tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24064222&form=6&db=m Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involve suppression of oxidative stress and inflammatory cytokines. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24070708&form=6&db=m The p38 MAPK inhibitor JLU1124 inhibits the inflammatory response induced by lipopolysaccharide through the MAPK-NF-?B pathway in RAW264.7 macrophages. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24071564&form=6&db=m Piperine inhibits LPS induced expression of inflammatory mediators in RAW 264.7 cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073414&form=6&db=m The ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24082899&form=6&db=m In vitro cytotoxic evaluation of some synthesized COX-2 inhibitor derivatives against a panel of human cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24083698&form=6&db=m Cyclooxygenase-2 Expression in Urinary Bladder Transitional Cell Carcinoma and its Association with Clinicopathological Characteristics. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24084728&form=6&db=m Cytokines, Chaperones and Neuroinflammatory Responses in Heroin-Related Death: What Can We Learn from Different Patterns of Cellular Expression? diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24088353&form=6&db=m Medicinal Chemistry and Pharmacology Focused on Cannabidiol, a Major Component of the Fiber-Type Cannabis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24091559&form=6&db=m New diagnostic markers in salivary gland tumors. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24100466&form=6&db=m Overcoming paclitaxel resistance in uterine endometrial cancer using a COX-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24101135&form=6&db=m A comparison on expression of selected biomarkers between primary lung cancers and matched metastases. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24114663&form=6&db=m Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-?B signaling pathway in BV-2 microglia. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24124509&form=6&db=m Bamboo vinegar decreases inflammatory mediator expression and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and protein kinase C-?/? activation. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126114&form=6&db=m Amentoflavone inhibits iNOS, COX-2 expression and modulates cytokine profile, NF-?B signal transduction pathways in rats with ulcerative colitis. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127882&form=6&db=m Cyclooxygenase-2 inhibitor suppresses tumour progression of prostate cancer bone metastases in nude mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127927&form=6&db=m Initiation of aspirin therapy modulates angiogenic protein levels in women with breast cancer receiving tamoxifen therapy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24132147&form=6&db=m Erucin exerts anti-inflammatory properties in murine macrophages and mouse skin: possible mediation through the inhibition of NF?B signaling. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24137401&form=6&db=m Cyclooxygenase-2 expression in the tumor environment is associated with poor prognosis in colorectal cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24138533&form=6&db=m Characterization of microsomal prostaglandin E synthase 1 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24144632&form=6&db=m JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24145766&form=6&db=m Synthesis of three 18F-labelled cyclooxygenase-2 (COX-2) inhibitors based on a pyrimidine scaffold. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24146106&form=6&db=m First Evidence for the Anti-inflammatory Activity of Fucoxanthin in High-Fat-Diet-Induced Obesity in Mice and the Antioxidant Functions in PC12 Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24146280&form=6&db=m Cyclooxygenase 2 promoted the tumorigenecity of pancreatic cancer cells. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24151540&form=6&db=m Colon Macrophages Polarized by Commensal Bacteria Cause Colitis and Cancer through the Bystander Effect. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24166135&form=6&db=m Preclinical Studies of a Specific PPAR? Modulator in the Control of Skin Inflammation. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24176842&form=6&db=m Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24177568&form=6&db=m NF-?B-targeted anti-inflammatory activity of Prunella vulgaris var. lilacina in macrophages RAW 264.7. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24184161&form=6&db=m Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24190633&form=6&db=m A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-?B in HCT116 human colon cancer cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24200121&form=6&db=m Fluorescence discrimination of cancer from inflammation by molecular response to COX-2 enzymes. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24202549&form=6&db=m Selenium Inhibits LPS-Induced Pro-inflammatory Gene Expression by Modulating MAPK and NF-?B Signaling Pathways in Mouse Mammary Epithelial Cells in Primary Culture. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24211275&form=6&db=m Intake of high-fat diet stimulates the risk of ultraviolet radiation-induced skin tumors and malignant progression of papillomas to carcinoma in SKH-1 hairless mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24213465&form=6&db=m Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24220240&form=6&db=m 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24233024&form=6&db=m Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24243648&form=6&db=m Intratumoral COX-2 inhibition enhances GM-CSF immunotherapy against established mouse GL261 brain tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24244531&form=6&db=m Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24244819&form=6&db=m Kalopanaxsaponin A Exerts Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated Microglia via Inhibition of JNK and NF-?B/AP-1 Pathways. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24244826&form=6&db=m Ginsenoside rg3 alleviates lipopolysaccharide-induced learning and memory impairments by anti-inflammatory activity in rats. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24250402&form=6&db=m Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24250585&form=6&db=m Anti-inflammatory Effects of Oxymatrine Through Inhibition of Nuclear Factor-kappa B and Mitogen-activated Protein Kinase Activation in Lipopolysaccharide-induced BV2 Microglia Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24250718&form=6&db=m Methanol Extract of Artemisia apiacea Hance Attenuates the Expression of Inflammatory Mediators via NF- ? B Inactivation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24259966&form=6&db=m Role of cyclooxygenase-2 in gastric cancer development and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24260338&form=6&db=m Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24260743&form=6&db=m Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/?-catenin and COX-2 pathways. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24268915&form=6&db=m Targeted Cox2 gene deletion in intestinal epithelial cells decreases tumorigenesis in female, but not male, ApcMin/+ mice. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24269623&form=6&db=m Protective effect of marine mangrove Rhizophora apiculata on acetic acid induced experimental colitis by regulating anti-oxidant enzymes, inflammatory mediators and nuclear factor-kappa B subunits. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24275590&form=6&db=m Cytotoxic and apoptotic functions of licofelone on rat glioma cells. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24281210&form=6&db=m Surgery as a double-edged sword: a clinically feasible approach to overcome the metastasis-promoting effects of surgery by blunting stress and prostaglandin responses. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24287292&form=6&db=m Endothelial PKC?-MAPK/ERK-phospholipase A2 pathway activation as a response of glioma in a triple culture model. A new role for pericytes? causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24288559&form=6&db=m Inhibition of Acute Phase Inflammation by Laminaria japonica through Regulation of iNOS-NF- ? B Pathway. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24291175&form=6&db=m Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24300090&form=6&db=m Enhanced in-vitro and in-vivo suppression of A375 melanoma by combined IL-24/OSM adenoviral-mediated gene therapy. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24306215&form=6&db=m Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24308155&form=6&db=m Enhancement of antitumor activity by combination of tumor lysate-pulsed dendritic cells and celecoxib in a rat glioma model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24320209&form=6&db=m Two novel anti-inflammatory 21-nordammarane saponins from tetraploid Jiaogulan ( Gynostemma pentaphyllum ). ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24324582&form=6&db=m High MUC2 expression in ovarian cancer is inversely associated with the M1/M2 ratio of tumor-associated macrophages and patient survival time. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24324683&form=6&db=m Lack of RNase L attenuates macrophage functions. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24325753&form=6&db=m Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24327271&form=6&db=m Aspirin and colorectal cancer: back to the future. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24328676&form=6&db=m ?-sitosteryl-3-O-?-glucopyranoside isolated from the bark of Sorbus commixta ameliorates pro-inflammatory mediators in RAW 264.7 macrophages. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24331369&form=6&db=m Aspirin reduces lung cancer metastasis to regional lymph nodes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24338666&form=6&db=m CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24338843&form=6&db=m Effect of Fucoxanthin Alone and in Combination with D-glucosamine Hydrochloride on Carrageenan/kaolin-induced Experimental Arthritis in Rats. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24344016&form=6&db=m Lentivirus-mediated shRNA interference targeting cyclooxygenase-2 inhibits growth of human non-small cell lung cancer. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24345644&form=6&db=m COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24348690&form=6&db=m Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24348728&form=6&db=m Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF- ? B and MAPK in RAW 264.7 Cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24348786&form=6&db=m Forsythiaside attenuates lipopolysaccharide-induced inflammatory responses in the bursa of Fabricius of chickens by downregulating the NF-?B signaling pathway. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24349176&form=6&db=m Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354175&form=6&db=m Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24355064&form=6&db=m HEMA-induced cytotoxicity: oxidative stress, genotoxicity and apoptosis. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24363499&form=6&db=m Conditioned media from adipose-tissue-derived mesenchymal stem cells downregulate degradative mediators induced by interleukin-1? in osteoarthritic chondrocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24364787&form=6&db=m Silibinin inhibits tumor promotional triggers and tumorigenesis against chemically induced two-stage skin carcinogenesis in Swiss albino mice: possible role of oxidative stress and inflammation. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24369537&form=6&db=m Low-cytotoxic synthetic bromorutaecarpine exhibits anti-inflammation and activation of transient receptor potential vanilloid type 1 activities. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24369884&form=6&db=m Inhibitory Effects of 4-Hydroxyderricin and Xanthoangelol on Lipopolysaccharide-Induced Inflammatory Responses in RAW264 Macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24372204&form=6&db=m A Lipid Anchor Improves the Protective Effect of Ectoine in Inflammation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24372526&form=6&db=m Sesamol Ameliorates Cyclophosphamide-Induced Hepatotoxicity by Modulating Oxidative Stress and Inflammatory Mediators. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24374147&form=6&db=m Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24374755&form=6&db=m Research progress of ursolic acid's anti-tumor actions. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24374992&form=6&db=m Spinal nuclear factor-kappa B (NF-?B) p65 activation contributes to peripheral inflammation and hyperalgesia in rat adjuvant-induced arthritis. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24376205&form=6&db=m Fluorophore-labeled cyclooxygenase-2 inhibitors for the imaging of cyclooxygenase-2 overexpression in cancer: synthesis and biological studies. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379523&form=6&db=m IRAK1/4-targeted anti-inflammatory action of caffeic acid. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24384558&form=6&db=m 5-Methoxytryptophan-dependent protection of cardiomyocytes from heart ischemia reperfusion injury. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24387269&form=6&db=m Cyclooxygenase-2 and B-cell lymphoma-2 expression in cystitis glandularis and primary vesicle adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24390670&form=6&db=m Nuclear expression of ?-catenin predicts the efficacy of meloxicam treatment for patients with sporadic desmoid tumors. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24396479&form=6&db=m Study of the polymorphisms of cyclooxygenase-2 (-765G>C) and 5-lipoxygenase (1708G>A) in patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24398114&form=6&db=m Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24402873&form=6&db=m Lack of association between cyclooxygenase 2-765G/C gene polymorphism and breast cancer risk in Ahvaz, west-south Iran. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24413338&form=6&db=m Chronic Arsenic Exposure and Angiogenesis in Human Bronchial Epithelial Cells via the ROS/miR-199a-5p/HIF-1?/COX-2 Pathway. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24416158&form=6&db=m Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24432383&form=6&db=m Asiatic acid from Potentilla chinensis attenuate ethanol-induced hepatic injury via suppression of oxidative stress and Kupffer cell activation. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24434582&form=6&db=m Integrin ?3?1 controls mRNA splicing that determines Cox-2 mRNA stability in breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24436266&form=6&db=m NF-?B and COX-2 expression in nonmalignant endometrial lesions and cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24438088&form=6&db=m The novel IGF-IR/Akt-dependent anticancer activities of glucosamine. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24443892&form=6&db=m Desmoid tumor-associated pain is dependent on mast cell expression of cyclooxygenase-2. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24446952&form=6&db=m Cyclooxygenase-2 in epilepsy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24458827&form=6&db=m "Letter to editor" in lieu of article published in Mol Biol Rep. 2012 May; 39(5):5219-24. PTGS2 (COX2) -765G>C gene polymorphism and risk of sporadic colorectal cancer in Iranian population. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24467618&form=6&db=m COX-2 signaling and cancer: new players in old arena. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24468133&form=6&db=m Novel anti-inflammatory function of NSC95397 by the suppression of multiple kinases. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469308&form=6&db=m Cell-type-specific roles for COX-2 in UVB-induced skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469360&form=6&db=m Association between cyclooxygenase-2 gene polymorphisms and head and neck squamous cell carcinoma risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24470172&form=6&db=m Imaging COX-2 expression in cancer using PET/SPECT radioligands: current status and future directions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24474144&form=6&db=m A newly synthesized compound, 4'-geranyloxyferulic acid-N(omega)-nitro-l-arginine methyl ester suppresses inflammation-associated colorectal carcinogenesis in male mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24474433&form=6&db=m The Neoflavonoid Latifolin Isolated from MeOH Extract of Dalbergia odorifera Attenuates Inflammatory Responses by Inhibiting NF-?B Activation via Nrf2-Mediated Heme Oxygenase-1 Expression. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24481495&form=6&db=m Ultraviolet radiation-induced inflammation activates ?-catenin signaling in mouse skin and skin tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24485892&form=6&db=m Arylbenzofuran isolated from Dalbergia odorifera suppresses lipopolysaccharide-induced mouse BV2 microglial cell activation, which protects mouse hippocampal HT22 cells death from neuroinflammation-mediated toxicity. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24490043&form=6&db=m Gefitinib and celecoxib in advanced metastatic gastrointestinal tumors: a pilot feasibility study. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24492591&form=6&db=m Cembranoid diterpenes from the soft coral Lobophytum crassum and their anti-inflammatory activities. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24503782&form=6&db=m Usefulness of selective COX-2 inhibitors as therapeutic agents against canine mammary tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24505512&form=6&db=m Cyclooxygenase-2 expression in lymphoma in north-west of iran. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24509133&form=6&db=m Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24513875&form=6&db=m Hippocampal dysfunctions in tumor-bearing mice. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24516579&form=6&db=m Overexpression of cyclooxygenase-2 in malignant peripheral nerve sheath tumor and selective cyclooxygenase-2 inhibitor-induced apoptosis by activating caspases in human malignant peripheral nerve sheath tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24518566&form=6&db=m Physiological COX-2 Expression in Breast Epithelium Associates with COX-2 Levels in Ductal Carcinoma in Situ and Invasive Breast Cancer in Young Women. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24520227&form=6&db=m Synergistic Effect of COX-2 Inhibitor on Paclitaxel-Induced Apoptosis in the Human Ovarian Cancer Cell Line OVCAR-3. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24528083&form=6&db=m Simultaneous blockage of epidermal growth factor receptor and cyclooxygenase-2 in a human xenotransplanted lung cancer model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24530660&form=6&db=m Acute exposure to lead acetate activates microglia and induces subsequent bystander neuronal death via caspase-3 activation. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24533777&form=6&db=m The Role of Anti-LeY Antibody in the Downregulation of MAPKs/COX-2 Pathway in Gastric Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535190&form=6&db=m COX-2 silencing enhances tamoxifen antitumor activity in breast cancer in vivo and in vitro. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24535229&form=6&db=m A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24549815&form=6&db=m Combining sorafenib with celecoxib synergistically inhibits tumor growth of non-small cell lung cancer cells in vitro and in vivo. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24550603&form=6&db=m Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24553301&form=6&db=m Significance of uroplakin III expression in recurrence of solitary muscle non-invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24555677&form=6&db=m Size-dependent effect of zinc oxide on toxicity and inflammatory potential of human monocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24563620&form=6&db=m Paradoxically augmented anti-tumorigenic action of proton pump inhibitor and GastrininAPCMin/+ intestinal polyposis model. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24576481&form=6&db=m Ethyl pyruvate ameliorates 3-nitropropionic acid-induced striatal toxicity through anti-neuronal cell death and anti-inflammatory mechanisms. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24582516&form=6&db=m Targeted therapies in metastatic esophageal cancer: Advances over the past decade. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24589238&form=6&db=m 5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24590894&form=6&db=m Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24591842&form=6&db=m Cyclooxygenase-2 inhibitor is a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24593990&form=6&db=m Chromene suppresses the activation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24599585&form=6&db=m Impact of COX2 genotype, ER status and body constitution on risk of early events in different treatment groups of breast cancer patients. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24603686&form=6&db=m The Bitter Barricading of Prostaglandin Biosynthesis Pathway: Understanding the Molecular Mechanism of Selective Cyclooxygenase-2 Inhibition by Amarogentin, a Secoiridoid Glycoside from Swertia chirayita. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24608632&form=6&db=m Differences in Expression of Uroplakin III, Cytokeratin 7, and Cyclooxygenase-2 in Canine Proliferative Urothelial Lesions of the Urinary Bladder. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24611100&form=6&db=m Ethanol extract of Synurus deltoides (Aiton) Nakai suppresses in vitro LPS-induced cytokine production in RAW 264.7 macrophages and in vivo acute inflammatory symptoms. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24631516&form=6&db=m Madecassoside prevents A?25-35-induced inflammatory responses and autophagy in neuronal cells through the class III PI3K/Beclin-1/Bcl-2 pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24632333&form=6&db=m Photodynamic Therapeutic Role of Indocyanine Green in Tumor-Associated Inflammation in Skin Cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24639330&form=6&db=m Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24640098&form=6&db=m Expression of molecular markers in low-grade chondrosarcomas and cartilaginous tumors with uncertain differentiation. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24640603&form=6&db=m Cyclooxygenase-2 inhibitor celecoxib suppresses invasion and migration of nasopharyngeal carcinoma cell lines through a decrease in matrix metalloproteinase-2 and -9 activity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24641487&form=6&db=m Inhibitory Effect of Litchi (Litchi chinensis Sonn.) Flower on Lipopolysaccharide-Induced Expression of Proinflammatory Mediators in RAW264.7 Cells through NF-?B, ERK, and JAK2/STAT3 Inactivation. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24647425&form=6&db=m Antitumor effect of a selective COX-2 inhibitor, celecoxib, may be attributed to angiogenesis inhibition through modulating the PTEN/PI3K/Akt/HIF-1 pathway in an H22 murine hepatocarcinoma model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649093&form=6&db=m Effect of celecoxib plus standard chemotherapy on serum levels of vascular endothelial growth factor and cyclooxygenase-2 in patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24652195&form=6&db=m Comparison of Photoacoustically Derived Hemoglobin and Oxygenation Measurements with Contrast-Enhanced Ultrasound Estimated Vascularity and Immunohistochemical Staining in a Breast Cancer Model. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24656746&form=6&db=m Antitumor effects of celecoxib in COX-2 expressing and non-expressing canine melanoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24659686&form=6&db=m COX-2 overexpression increases malignant potential of human glioma cells through Id1. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24660685&form=6&db=m Novel Dual Inhibitors Of Nuclear Factor-Kappa B (NF-?b) And Cyclooxygenase-2 (COX-2): Synthesis, In Vitro Anticancer Activity And Stability Studies Of Lantadene-Non Steroidal Anti-Inflammatory Drug (NSAID) Conjugates. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24666548&form=6&db=m The impact of COX-2 on invasion of osteosarcoma cell and its mechanism of regulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24669166&form=6&db=m Role of Cyclooxygenase 2 (COX-2) in Prognosis of Breast Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24675684&form=6&db=m Meloxicam Executes Its Antitumor Effects against Hepatocellular Carcinoma in COX-2- Dependent and -Independent Pathways. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681547&form=6&db=m Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681731&form=6&db=m Cox-2, EGFR, and ERBB-2 Expression in Cervical Intraepithelial Neoplasia and Cervical Cancer Using an Automated Imaging System. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24683330&form=6&db=m Anesthetic Techniques and Cancer Recurrence after Surgery. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24684352&form=6&db=m Naringenin attenuates CCl4 induced hepatic inflammation by the activation of Nrf2 mediated pathway in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24684440&form=6&db=m Levuglandin Forms Adducts with Histone H4 in a Cyclooxygenase-2-Dependent Manner, Altering Its Interaction with DNA. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24687028&form=6&db=m Expression of HLA Class I Antigen, Aspirin Use, and Survival After a Diagnosis of Colon Cancer. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24688218&form=6&db=m Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc (Min/+) mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24691249&form=6&db=m Effect of hesperidin and neohesperidin from bittersweet orange (Citrus aurantium var. bigaradia) peel on indomethacin-induced peptic ulcers in rats. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24704993&form=6&db=m MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24708725&form=6&db=m Post-diagnostic prescriptions for low-dose aspirin and breast cancer-specific survival: a nested case-control study in a breast cancer cohort from the UK Clinical Practice. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24716101&form=6&db=m Anti-inflammatory activity of traditional Chinese medicinal herbs. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24719521&form=6&db=m Anti-inflammatory and antinociceptive activities of bufalin in rodents. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24721996&form=6&db=m Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24726874&form=6&db=m Aspirin-induced inhibition of adipogenesis was p53-dependent and associated with inactivation of pentose phosphate pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24733273&form=6&db=m Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24735446&form=6&db=m Thymoquinone therapy abrogates toxic effect of cadmium on rat testes. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24735610&form=6&db=m The rigid steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a dissociated glucocorticoid receptor modulator potentially useful as a novel coadjuvant in breast cancer chemotherapy. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24735815&form=6&db=m Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-?B, MAPK and AP-1 signaling pathways in macrophages. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24736319&form=6&db=m Network analysis of inflammatory genes and their transcriptional regulators in coronary artery disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24736977&form=6&db=m Pulmonary toxicity in mice following exposure to cerium chloride. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24747121&form=6&db=m Sulforaphane inhibits phorbol ester-stimulated IKK-NF-?B signaling and COX-2 expression in human mammary epithelial cells by targeting NF-?B activating kinase and ERK. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24756575&form=6&db=m NF-?B signaling modulates radiation?induced microglial activation. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24760190&form=6&db=m Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24767309&form=6&db=m Aspartate alleviates liver injury and regulates mRNA expressions of TLR4 and NOD signaling-related genes in weaned pigs after lipopolysaccharide challenge. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24771982&form=6&db=m Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24772817&form=6&db=m Anti-inflammatory activity of selected plants from Saudi Arabia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24779988&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 and brain fatty acid binding protein expression in grades I-II meningiomas: Correlation with tumor grade and clinical outcome after radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24782611&form=6&db=m Inflammation-related factors predicting prognosis of gastric cancer. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24788118&form=6&db=m CTNNB1 S45F mutation predicts poor efficacy of meloxicam treatment for desmoid tumors: a pilot study. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24792328&form=6&db=m Investigation of the effects of short-term inhalation of carbon nanoparticles on brains and lungs of c57bl/6j and p47(phox-/-) mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24792472&form=6&db=m Cyclooxygenase 2-mediated apoptotic and inflammatory responses in photodynamic therapy treated breast adenocarcinoma cells and xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24795386&form=6&db=m Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24796667&form=6&db=m PLC?1: a potential target of RNA interference therapy for gastric cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24799907&form=6&db=m Therapy with interleukin-22 alleviates hepatic injury and hemostasis dysregulation in rat model of acute liver failure. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24802614&form=6&db=m COX-2 inhibitors arrest prostate cancer cell cycle progression by down-regulation of kinetochore/centromere proteins. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24803181&form=6&db=m Effects of Lithium on Inflammation. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24804836&form=6&db=m Cyclooxygenases: Mediators of UV-Induced Skin Cancer and Potential Targets for Prevention. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24813155&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in normal, hyperplastic and neoplastic canine lymphoid tissues. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24814703&form=6&db=m Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24817032&form=6&db=m Role of microRNAs in resveratrol-mediated mitigation of colitis-associated tumorigenesis in Apc(Min/+) mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24818718&form=6&db=m The role of inflammation in colon cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24818724&form=6&db=m The role of inflammation in bladder cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819958&form=6&db=m A selective cyclooxygenase-2 inhibitor (Etodolac) prevents spontaneous biliary tumorigenesis in a hamster bilioenterostomy model. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24824420&form=6&db=m COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24825998&form=6&db=m Rofecoxib prevents ctdsDNA against damage induced by copper sulfate and ultraviolet B radiation in vitro study. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24826036&form=6&db=m Inflammation, macrophage in cancer progression and chinese herbal treatment. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24828543&form=6&db=m Dynamic microbe and molecule networks in a mouse model of colitis-associated colorectal cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830713&form=6&db=m Molecular docking and fluorescence characterization of benzothieno[3,2-d]pyrimidin-4-one sulphonamide thio-derivatives, a novel class of selective cyclooxygenase-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24832612&form=6&db=m PET radiotracer [¹?F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24835302&form=6&db=m Curcumin induces apoptosis and inhibits growth of orthotopic human non-small cell lung cancer xenografts. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24836925&form=6&db=m Wine polyphenols exert antineoplasic effect on androgen resistant PC-3 cell line through the inhibition of the transcriptional activity of COX-2 promoter mediated by NF-k?. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24842612&form=6&db=m TREM-1 is induced in tumor associated macrophages by cyclo-oxygenase pathway in human non-small cell lung cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24843008&form=6&db=m p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-?B complexes. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24859418&form=6&db=m COX2 expression in neuroblastoma increases tumorigenicity but does not affect cell death in response to the COX2 inhibitor celecoxib. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24859472&form=6&db=m Metastatic potential in MDA-MB-231 human breast cancer cells is inhibited by proton beam irradiation via the Akt/nuclear factor-?B signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24860830&form=6&db=m Antitumor and antiangiogenic activities of curcumin in cervical cancer xenografts in nude mice. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24870748&form=6&db=m The prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/ COX2) rs5277 polymorphism does not influence risk of colorectal cancer in an Iranian population. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24874440&form=6&db=m Emodin inhibits LPS-induced inflammatory response by activating PPAR-? in mouse mammary epithelial cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24878108&form=6&db=m Different detectability of cyclooxygenase-2 (COX-2) protein in standard paraffin sections and tissue microarrays of human melanomas and naevi - Comparative study. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24880019&form=6&db=m Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-?B activities. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24883266&form=6&db=m The influence of Cox-2 and bioactive lipids on hematological cancers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24887090&form=6&db=m Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24900856&form=6&db=m Trifluoromethyl fluorocoxib a detects cyclooxygenase-2 expression in inflammatory tissues and human tumor xenografts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24906923&form=6&db=m Effects of RU486 and indomethacin on meiotic maturation, formation of extracellular matrix, and progesterone production by porcine oocyte-cumulus complexes. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24908110&form=6&db=m Effects of selenium-enriched Agaricus blazei Murill on liver metabolic dysfunction in mice, a comparison with selenium-deficient Agaricus blazei Murill and sodium selenite. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24908358&form=6&db=m Aspirin may modify tumor microenvironment via antiplatelet effect. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24912820&form=6&db=m Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24916702&form=6&db=m Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24922641&form=6&db=m Heparanase and COX-2 expression as predictors of lymph node metastasis in large, high-grade breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24924994&form=6&db=m The role of adiponectin in endothelial dysfunction and hypertension. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24932579&form=6&db=m A role for cAMP-driven transactivation of EGFR in cancer aggressiveness - therapeutic implications. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24944640&form=6&db=m Preventive effect of polysaccharides from the large yellow croaker swim bladder on HCl/ethanol induced gastric injury in mice. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24956234&form=6&db=m Protective effect of Ginkgo biloba leaves extract, EGb761, on endotoxin-induced acute lung injury via a JNK- and Akt-dependent NF?B pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24958816&form=6&db=m G?13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24959102&form=6&db=m The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24961358&form=6&db=m Tetramethylpyrazine (TMP) protects against sodium arsenite-induced nephrotoxicity by suppressing ROS production, mitochondrial dysfunction, pro-inflammatory signaling pathways and programed cell death. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24964992&form=6&db=m COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24965577&form=6&db=m Autocrine prostaglandin E2 signaling promotes promonocytic leukemia cell survival via COX-2 expression and MAPK pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24969538&form=6&db=m Characterization of the inflammatory microenvironment and identification of potential therapeutic targets in wilms tumors. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24969885&form=6&db=m Cyclooxygenase-2 promoter 765C increase of digestive tract cancer risk in the Chinese population: a meta-analysis. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24975100&form=6&db=m The synergetic effect of edaravone and borneol in the rat model of ischemic stroke. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24975555&form=6&db=m Molecular mechanisms of low dose ionizing radiation-induced hormesis, adaptive responses, radioresistance, bystander effects, and genomic instability. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24975834&form=6&db=m Hepatoprotective effects of Mimic of Manganese superoxide dismutase against carbon tetrachloride-induced hepatic injury. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24981602&form=6&db=m Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24990856&form=6&db=m Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24991534&form=6&db=m Carvedilol ameliorates early diabetic nephropathy in streptozotocin-induced diabetic rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24992958&form=6&db=m Cyclooxygenase-2 inhibition as a strategy for treating gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24998576&form=6&db=m Associations between single nucleotide polymorphisms of COX-2 and MMP-2 genes and colorectal cancer susceptibility in the Saudi population. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24999478&form=6&db=m Alterations in lipid mediated signaling and Wnt/ ? -catenin signaling in DMH induced colon cancer on supplementation of fish oil. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25003704&form=6&db=m Modulation of hyperglycemia and TNF?-mediated inflammation by helichrysum and grapefruit extracts in diabetic db/db mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25006014&form=6&db=m Estradiol-potentiated cadherin-11 in synovial membrane involves in temporomandibular joint inflammation in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25007180&form=6&db=m Immunohistochemical visualization of pro-inflammatory cytokines and enzymes in ovarian tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25011213&form=6&db=m COX-2 expression pattern is related to ovarian cancer differentiation and prognosis, but is not consistent with new model of pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25011266&form=6&db=m [Chemo-preventive effect of Angelica sinensis' supercritical extracts on AOM/DSS-induced mouse colorectal carcinoma associated with inflammation]. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25014793&form=6&db=m Activation of Poly(ADP-Ribose) Polymerase-1 Delays Wound Healing by Regulating Keratinocyte Migration and Production of Inflammatory Mediators. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25016505&form=6&db=m Efficacy and safety profile of celecoxib for treating advanced cancers: a meta-analysis of 11 randomized clinical trials. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25019221&form=6&db=m ?-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25022336&form=6&db=m Immunizations with unmodified tumor cells and simultaneous COX-2 inhibition eradicate malignant rat brain tumors and induce a long-lasting CD8(+) T cell memory. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25023988&form=6&db=m A low carbohydrate, high protein diet combined with celecoxib markedly reduces metastasis. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25024195&form=6&db=m Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25036966&form=6&db=m Bovine milk-derived ?-lactalbumin inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sodium sulfate-treated mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25038765&form=6&db=m Interleukin-17 Indirectly Promotes M2 Macrophage Differentiation through Stimulation of COX-2/PGE2 Pathway in the Cancer Cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25043994&form=6&db=m Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injury. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25047043&form=6&db=m Regulation of COX-2 expression by miR-146a in lung cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054040&form=6&db=m Cyclooxygenase-2 inhibitors for non-small-cell lung cancer: A phase II trial and literature review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054056&form=6&db=m Cyclooxygenase-2 expression in non-metastatic triple-negative breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054106&form=6&db=m Antioxidant and Anti-inflammatory Effects of Yam (Dioscorea batatas Decne.) on Azoxymethane-induced Colonic Aberrant Crypt Foci in F344 Rats. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25057941&form=6&db=m Co-targeting c-Met and COX-2 leads to enhanced inhibition of lung tumorigenesis in a murine model with heightened airway HGF. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25060643&form=6&db=m Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25060857&form=6&db=m Overexpression of Wild-Type p53-Induced Phosphatase 1 Confers Poor Prognosis of Patients with Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25062774&form=6&db=m Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-?B signaling pathways in SKH-1 hairless mice skin. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25063314&form=6&db=m Heme oxygenase-1 expression is associated with tumor aggressiveness and outcomes in patients with bladder cancer: a correlation with smoking intensity. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25063587&form=6&db=m Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25064845&form=6&db=m miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25066075&form=6&db=m New celecoxib multiparticulate systems to improve glioblastoma treatment. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25072100&form=6&db=m Targeted nanogel conjugate for improved stability and cellular permeability of curcumin: synthesis, pharmacokinetics, and tumor growth inhibition. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25074039&form=6&db=m Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25077370&form=6&db=m COX-2, p16 and Ki67 expression in DCIS, microinvasive and early invasive breast carcinoma with extensive intraductal component. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25080336&form=6&db=m Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25083618&form=6&db=m Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25083990&form=6&db=m Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25088297&form=6&db=m Proanthocyanidins improves lead-induced cognitive impairments by blocking endoplasmic reticulum stress and nuclear factor-?B-mediated inflammatory pathways in rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25090227&form=6&db=m A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25093007&form=6&db=m Primary and secondary prevention of colorectal cancer. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25098909&form=6&db=m Breaking the cycle: the role of omega-3 polyunsaturated fatty acids in inflammation-driven cancers. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25102246&form=6&db=m Anti-inflammatory activity of omphalocarpin isolated from Radix Toddaliae Asiaticae. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25102875&form=6&db=m [Expression and clinical significance of Cox-2 and XIAP in malignant tumors of the salivary gland]. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25106885&form=6&db=m Triterpene glycosides from red ginseng marc and their anti-inflammatory activities. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25113252&form=6&db=m COX-2 overexpression and -8473 T/C polymorphism in 3' UTR in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25114833&form=6&db=m Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25115103&form=6&db=m Essential oil from leaves of Liquidambar formosana ameliorates inflammatory response in lipopolysaccharide-activated mouse macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25118473&form=6&db=m Breast cancer--new aspects of tumor biology: are calcitriol and cyclooxygenase-2 possible targets for breast cancer? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25120639&form=6&db=m Progesterone protects blood-brain barrier function and improves neurological outcome following traumatic brain injury in rats. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25125751&form=6&db=m Role of inflammation and inflammatory mediators in colorectal cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25126080&form=6&db=m Expression of the prostaglandin F synthase AKR1B1 and the prostaglandin transporter SLCO2A1 in human fetal membranes in relation to spontaneous term and preterm labor. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25130519&form=6&db=m CD8+ tumour-infiltrating lymphocytes and COX2 expression may predict relapse in differentiated thyroid cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131506&form=6&db=m The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25131817&form=6&db=m Prognostic value of cyclooxygenase-2 gene polymorphisms in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25133423&form=6&db=m Inflammatory lymphangiogenesis in postpartum breast tissue remodeling. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25133426&form=6&db=m Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25137041&form=6&db=m Expression of STAT5, COX-2 and PIAS3 in correlation with NSCLC histhopathological features. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25139833&form=6&db=m Prostaglandin E2 produced by inducible COX-2 and mPGES-1 promoting cancer cell proliferation in vitro and in vivo. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25143807&form=6&db=m Cytochalasin B modulates macrophage-mediated inflammatory responses. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25144313&form=6&db=m Highly sensitive naphthalene-based two-photon fluorescent probe for in situ real-time bioimaging of ultratrace cyclooxygenase-2 in living biosystems. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25145772&form=6&db=m SeMet mediates anti-inflammation in LPS-induced U937 cells targeting NF-?B signaling pathway. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25151216&form=6&db=m Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(?)anthracene-induced rat mammary carcinoma. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25152576&form=6&db=m Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25153536&form=6&db=m Serum metabolites from walnut-fed aged rats attenuate stress-induced neurotoxicity in BV-2 microglial cells. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162585&form=6&db=m 6-Dehydrogingerdione restrains lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25166592&form=6&db=m Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25166905&form=6&db=m Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25168879&form=6&db=m Staurosporine synergistically potentiates the deoxycholate-mediated induction of COX-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25171128&form=6&db=m ?-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPAR? pathway. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25171787&form=6&db=m Primary sensory neurons regulate Toll-like receptor-4-dependent activity of glial cells in dorsal root ganglia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25172294&form=6&db=m Oesophageal squamous cell carcinoma in high-risk Chinese populations: Possible role for vascular epithelial growth factor A. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25175164&form=6&db=m Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKK?/NF-?B signaling pathway in lung cancer cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25175318&form=6&db=m Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: evidence from an animal model and a human cohort. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25176064&form=6&db=m The role of COX-2 in mediating the effect of PTEN on BMP9 induced osteogenic differentiation in mouse embryonic fibroblasts. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25188463&form=6&db=m Anti-colitic effects of kanjangs (fermented soy sauce and sesame sauce) in dextran sulfate sodium-induced colitis in mice. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25189466&form=6&db=m Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in LPS-induced mouse mastitis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25190452&form=6&db=m The long-acting COX-2 inhibitor mavacoxib (Trocoxil™) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25190639&form=6&db=m Fluence-dependent effects of low-level laser therapy in myofascial trigger spots on modulation of biochemicals associated with pain in a rabbit model. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25196524&form=6&db=m Artesunate induces apoptosis of bladder cancer cells by miR-16 regulation of COX-2 expression. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25199460&form=6&db=m Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25200026&form=6&db=m Phytochemical profile, antioxidative and anti-inflammatory potentials of Gynura bicolor DC. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202077&form=6&db=m Prognostic markers in early-stage colorectal cancer: significance of TYMS mRNA expression. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202373&form=6&db=m Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202381&form=6&db=m Effect of cycloxygenase-2 silencing on the malignant biological behavior of MCF-7 breast cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25210763&form=6&db=m Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25210855&form=6&db=m Cyclooxygenase-2 inhibition attenuates hypoxic cancer cells induced m2-polarization of macrophages. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25211298&form=6&db=m CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25213465&form=6&db=m Ursolic acid isolated from the seed of Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to Toll-like receptor 4 on macrophages. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25213948&form=6&db=m Pinolenic acid inhibits human breast cancer MDA-MB-231 cell metastasis in vitro. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25218510&form=6&db=m PGE2 Inhibits IL-10 Production via EP2-Mediated ?-Arrestin Signaling in Neuroinflammatory Condition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25222193&form=6&db=m Utility of Apc-mutant rats with a colitis-associated colon carcinogenesis model for chemoprevention studies. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25225463&form=6&db=m Expression of epidermal growth factor receptor, p53, Bcl2, vascular endothelial growth factor, cyclooxygenase-2, cyclin D1, human epidermal receptor-2 and Ki-67: Association with clinicopathological profiles and outcomes in gallbladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25230138&form=6&db=m Immunostimulatory activity of isoflavone-glycosides and ethanol extract from a fermented soybean product in human primary immune cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25231818&form=6&db=m A dual role for ?1 integrin in an in vitro Streptococcus mitis/human gingival fibroblasts co-culture model in response to TEGDMA. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25236577&form=6&db=m Analysis of microRNA expression signatures in malignant pleural mesothelioma, pleural inflammation, and atypical mesothelial hyperplasia reveals common predictive tumorigenesis-related targets. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25237168&form=6&db=m Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin E2 via COX-2 production without IL-1? and TNF-?. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25239119&form=6&db=m Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25239551&form=6&db=m Influence of seasonal variation on Thymus longicaulis C. Presl chemical composition and its antioxidant and anti-inflammatory properties. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25239868&form=6&db=m Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25241065&form=6&db=m Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25242400&form=6&db=m Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25243423&form=6&db=m Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25243883&form=6&db=m Modulating effect of Biophytum sensitivum extract on rats with acetic acid-induced ulcerative colitis. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25252849&form=6&db=m Hu-antigen receptor (HuR) and cyclooxygenase-2 (COX-2) expression in human non-small-cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25254309&form=6&db=m Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25256064&form=6&db=m Cytotoxic and anti-inflammatory tirucallane triterpenoids from Dysoxylum binectariferum. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25256272&form=6&db=m Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25258584&form=6&db=m Effect of celecoxib on inhibiting tumor repopulation during radiotherapy in human FaDu squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25260581&form=6&db=m Abacopteris penangiana exerts testosterone-induced benign prostatic hyperplasia protective effect through regulating inflammatory responses, reducing oxidative stress and anti-proliferative. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25266020&form=6&db=m Strategy for prevention of cancers of the esophagus. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25269624&form=6&db=m Stromal, rather than epithelial cyclooxygenase-2 (COX-2) expression is associated with overall survival of breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25287291&form=6&db=m Sasa quelpaertensis leaf extract suppresses dextran sulfate sodium-induced colitis in mice by inhibiting the proinflammatory mediators and mitogen-activated protein kinase phosphorylation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301050&form=6&db=m CXCR-4 and COX-2 Expression in Basal Cell Carcinomas and Well-Differentiated Squamous Cell Carcinomas of the Skin; Their Relationship with Tumor Invasiveness and Histological Subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301236&form=6&db=m Protective effects of maslinic acid against alcohol-induced acute liver injury in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25302170&form=6&db=m Cyclooxygenase-2 and the inflammogenesis of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25304264&form=6&db=m Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25305454&form=6&db=m Hepatitis C virus NS3 protein enhances cancer cell invasion by activating matrix metalloproteinase-9 and cyclooxygenase-2 through ERK/p38/NF-?B signal cascade. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310126&form=6&db=m Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25310697&form=6&db=m Inflammation and MiR-21 pathways functionally interact to downregulate PDCD4 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25318459&form=6&db=m Conjugation of cisplatin analogues and cyclooxygenase inhibitors to overcome cisplatin resistance. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25322760&form=6&db=m Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE? synthesis and COX-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25323036&form=6&db=m Regulation of ovulatory genes in bovine granulosa cells: lessons from siRNA silencing of PTGS2. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25325061&form=6&db=m Gallbladder cancer: Clinical and pathological approach. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25329155&form=6&db=m Toll-like receptor 2 mediates ischemia-reperfusion injury of the small intestine in adult mice. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25332964&form=6&db=m Clinical significance of the tumor microenvironment in non-small cell lung cancer. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25333664&form=6&db=m Effusanin E suppresses nasopharyngeal carcinoma cell growth by inhibiting NF-?B and COX-2 signaling. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25333891&form=6&db=m Celecoxib attenuates cachectic events in mice by modulating the expression of vascular endothelial growth factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25333935&form=6&db=m Vascular endothelial growth factor plays a critical role in the formation of the pre-metastatic niche via prostaglandin E2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25335121&form=6&db=m Effects of cyclooxygenase-2 gene silencing on the biological behavior of SKOV3 ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337538&form=6&db=m Cyclooxygenase-1 and -2: molecular targets for cervical neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25339021&form=6&db=m The -765G>C polymorphism in the cyclooxygenase-2 gene and digestive system cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25339948&form=6&db=m Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer Immunotherapy. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25340513&form=6&db=m Different Solvent Fractions of Acanthopanax senticosus Harms Exert Antioxidant and Anti-Inflammatory Activities and Inhibit the Human Kv1.3 Channel. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25343626&form=6&db=m TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25354213&form=6&db=m TRAMP prostate tumor growth is slowed by walnut diets through altered IGF-1 levels, energy pathways, and cholesterol metabolism. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25355039&form=6&db=m Prognostic value of COX-2, P53, and EZH-2 evaluated by quantitative image analysis in premalignant and malignant breast lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25356937&form=6&db=m A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25368279&form=6&db=m Evaluation of the contribution of cyclooxygenase 2 genotypes to breast cancer in Taiwan. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25369891&form=6&db=m Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25371868&form=6&db=m An observational study on the expression of cyclooxygenase-2 in meningioma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25374215&form=6&db=m Targeting of COX-2 expression by recombinant adenovirus shRNA attenuates the malignant biological behavior of breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25389774&form=6&db=m Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25405520&form=6&db=m JAK2 inhibitor blocks the inflammation and growth of esophageal squamous cell carcinoma in vitro through the JAK/STAT3 pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25408841&form=6&db=m Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25411520&form=6&db=m Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis in lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25413451&form=6&db=m Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25414768&form=6&db=m TI-I-174, a Synthetic Chalcone Derivative, Suppresses Nitric Oxide Production in Murine Macrophages via Heme Oxygenase-1 Induction and Inhibition of AP-1. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25414772&form=6&db=m Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422199&form=6&db=m MiR-1297 regulates the growth, migration and invasion of colorectal cancer cells by targeting cyclo-oxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25424129&form=6&db=m A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25429561&form=6&db=m EOP, a newly synthesized ethyl pyruvate derivative, attenuates the production of inflammatory mediators via p38, ERK and NF-?B pathways in lipopolysaccharide-activated BV-2 microglial cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433169&form=6&db=m Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25438689&form=6&db=m The CC-genotype of the cyclooxygenase-2 gene associates with decreased risk of nasopharyngeal carcinoma in a Tunisian population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25447157&form=6&db=m Cytotoxic, anti-inflammatory and hemostatic spirostane-steroidal saponins from the ethanol extract of the roots of Bletilla striata. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25448500&form=6&db=m Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: inhibition of NF-?B and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25449785&form=6&db=m Prognostic impact of COX-2 in non-small cell lung cancer: a comprehensive compartment-specific evaluation of tumor and stromal cell expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25455138&form=6&db=m A nuclear factor kappa B-derived inhibitor tripeptide inhibits UVB-induced photoaging process. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25460360&form=6&db=m Selenium deficiency sensitizes the skin for UVB-induced oxidative damage and inflammation which involved the activation of p38 MAPK signaling. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25464095&form=6&db=m Magnetic ligand fishing combination with high-performance liquid chromatography-diode array detector-mass spectrometry to screen and characterize cyclooxygenase-2 inhibitors from green tea. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25465718&form=6&db=m Anti-photoaging effect of aaptamine in UVB-irradiated human dermal fibroblasts and epidermal keratinocytes. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25465874&form=6&db=m Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25466270&form=6&db=m Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25470039&form=6&db=m Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25471032&form=6&db=m The role of prostaglandin E2 in renal cell cancer development: future implications for prognosis and therapy. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25477992&form=6&db=m In vivo and in vitro antitumor effects of platycodin d, a saponin purified from platycodi radix on the h520 lung cancer cell. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483152&form=6&db=m miR-26b is downregulated in human tongue squamous cell carcinoma and regulates cell proliferation and metastasis through a COX-2-dependent mechanism. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25487445&form=6&db=m Hypoxia promotes 786-O cells invasiveness and resistance to sorafenib via HIF-2?/COX-2. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25494361&form=6&db=m Analgesic and Anti-Inflammatory Activities of Rosa taiwanensis Nakai in Mice. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25494807&form=6&db=m Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25497868&form=6&db=m Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25501829&form=6&db=m Functional expression cloning identifies COX-2 as a suppressor of antigen-specific cancer immunity. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25503930&form=6&db=m Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25504431&form=6&db=m Wogonin Inhibits LPS-Induced Inflammatory Responses in Rat Dorsal Root Ganglion Neurons Via Inhibiting TLR4-MyD88-TAK1-Mediated NF-?B and MAPK Signaling Pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25511472&form=6&db=m Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25520883&form=6&db=m Prostaglandin receptors EP1-4 as a potential marker for clinical outcome in urothelial bladder cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25522551&form=6&db=m Essential oil from the heartwood of Taiwan fir ameliorates LPS-induced inflammatory response by inhibiting the activation of mitogen-activated protein kinase. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25528327&form=6&db=m Anti-inflammatory effects of a triple-bond resveratrol analog: structure and function relationship. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25529993&form=6&db=m Pierisformoside B exhibits neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells via the HO-1/Nrf2-mediated pathway. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25534849&form=6&db=m Cyclooxygenase-2 or Tumor Necrosis Factor-? Inhibitors Attenuate the Mechanotransductive Effects of Pulsed Focused Ultrasound to Suppress Mesenchymal Stromal Cell Homing to Healthy and Dystrophic Muscle. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25536376&form=6&db=m AMPK Activation Inhibits Expression of Proinflammatory Mediators Through Downregulation of PI3K/p38 MAPK and NF-?B Signaling in Murine Macrophages. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25545478&form=6&db=m Intracellular colon cancer-associated Escherichia coli promote protumoral activities of human macrophages by inducing sustained COX-2 expression. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25547723&form=6&db=m Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25550798&form=6&db=m Effect of celecoxib combined with chemotherapy drug on malignant biological behaviors of gastric cancer. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25553102&form=6&db=m Chitosan/siRNA nanoparticles targeting cyclooxygenase type 2 attenuate unilateral ureteral obstruction-induced kidney injury in mice. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25553117&form=6&db=m Parthenolide inhibits cancer stem-like side population of nasopharyngeal carcinoma cells via suppression of the NF-?B/COX-2 pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25557612&form=6&db=m Arachidonoyl-ethanolamide activates endoplasmic reticulum stress-apoptosis in tumorigenic keratinocytes: Role of cyclooxygenase-2 and novel J-series prostamides. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25574189&form=6&db=m Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25575894&form=6&db=m Expression of Cyclooxygenase-2 in Squamous Cell Carcinoma and Keratoacanthoma and its Clinical Significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579548&form=6&db=m Cyclo-oxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579788&form=6&db=m A single dose of PPAR? agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25582456&form=6&db=m In vitro anti-inflammatory properties of fermented pepino (Solanum muricatum) milk by ?-aminobutyric acid-producing Lactobacillus brevis and an in vivo animal model for evaluating its effects on hypertension. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587329&form=6&db=m Celecoxib Up Regulates the Expression of Drug Efflux Transporter ABCG2 in Breast Cancer Cell Lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587354&form=6&db=m Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595386&form=6&db=m Epidermal growth factor receptor-targeted immunoliposomes for delivery of celecoxib to cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595899&form=6&db=m Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595974&form=6&db=m Activation of NF-?B signaling pathway in HSV-1-induced mouse facial palsy: Possible relation to therapeutic effect of glucocorticoids. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25596094&form=6&db=m Amaryllidaceae alkaloids from the bulbs of Lycoris radiata with cytotoxic and anti-inflammatory activities. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25603423&form=6&db=m Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25609991&form=6&db=m An extract of the medicinal plant Artemisia annua modulates production of inflammatory markers in activated neutrophils. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25621771&form=6&db=m FLZ attenuates learning and memory deficits via suppressing neuroinflammation induced by LPS in mice. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25622900&form=6&db=m Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25625242&form=6&db=m Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25626516&form=6&db=m A novel caffeoyl triterpene attenuates cerebral ischemic injury with potent anti-inflammatory and hypothermic effects. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25636590&form=6&db=m Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25637769&form=6&db=m Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25642980&form=6&db=m 5-Lipoxygenase and Cyclooxygenase inhibitory Dammarane triterpenoid 1 from Borassus flabellifer seed coat, inhibits Tumor Necrosis Factor-? secretion in LPS induced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 Pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25643632&form=6&db=m HGF-activated colonic fibroblasts mediates carcinogenesis of colonic epithelial cancer cells via PKC-cMET-ERK1/2-COX-2 signaling. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25643791&form=6&db=m The potential role of COX-2 in cancer stem cell mediated canine mammary tumor initiation: an immunohistochemical study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25654405&form=6&db=m Downregulation of microglial activation by achillolide a. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25656916&form=6&db=m Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25658192&form=6&db=m Synthesis and biological evaluation of phenyl-1H-1,2,3-triazole derivatives as anti-inflammatory agents. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25669978&form=6&db=m Activating enhancer-binding protein-2? induces cyclooxygenase-2 thus promoting nasopharyngeal carcinoma growth. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25676325&form=6&db=m Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25683901&form=6&db=m Immunohistochemical Expression of Cyclooxygenase-2 (COX-2) in Feline Endometrial Adenocarcinoma and in Normal and Hyperplastic Endometria. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25684939&form=6&db=m Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25689583&form=6&db=m Orally Administrated Lactobacillus pentosus var. plantarum C29 Ameliorates Age-Dependent Colitis by Inhibiting the Nuclear Factor-Kappa B Signaling Pathway via the Regulation of Lipopolysaccharide Production by Gut Microbiota. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25691007&form=6&db=m Mitochondria of a human multidrug-resistant hepatocellular carcinoma cell line constitutively express inducible nitric oxide synthase in the inner membrane. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25693081&form=6&db=m Is there a place for practical chemoprevention of colorectal cancer in light of COX-2 heterogeneity? causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25695433&form=6&db=m Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701047&form=6&db=m COX-2 dependent regulation of mechanotransduction in human breast cancer cells. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25702964&form=6&db=m Intranasal PRGF-Endoret enhances neuronal survival and attenuates NF-?B-dependent inflammation process in a mouse model of Parkinson's disease. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25704623&form=6&db=m Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25705261&form=6&db=m Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25708949&form=6&db=m Protective effect of boswellic acids versus pioglitazone in a rat model of diet-induced non-alcoholic fatty liver disease: influence on insulin resistance and energy expenditure. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25731323&form=6&db=m [A case of desmoid tumor and advanced sigmoid colon cancer with liver metastasis in familial adenomatous polyposis (FAP)]. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25735986&form=6&db=m Inhibition of Neuroinflammation by Synthetic Androstene Derivatives Incorporating Amino Acid Methyl Esters on Activated BV-2 Microglia. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25736926&form=6&db=m Cannabis smoke can be a major risk factor for early-age laryngeal cancer-a molecular signaling-based approach. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25739980&form=6&db=m Modulation of HMGB1 translocation and RAGE/NF?B cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25740073&form=6&db=m The Role of the Mediators of Inflammation in Cancer Development. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25743830&form=6&db=m Cyclooxygenase-2 expression in invasive breast carcinomas of no special type and correlation with pathological profiles suggest a role in tumorigenesis rather than cancer progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748239&form=6&db=m Detection of Non-Melanoma Skin Cancer by in vivo Fluorescence Imaging with Fluorocoxib A. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25754990&form=6&db=m Inhibition of PKC-induced COX-2 and IL-8 Expression in Human Breast Cancer Cells by Glucosamine. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25765352&form=6&db=m Design, synthesis and evaluation of a series of non-steroidal anti-inflammatory drug conjugates as novel neuroinflammatory inhibitors. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25767678&form=6&db=m Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-?B. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25767687&form=6&db=m Diallyl Disulfide Prevents Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats through the Inhibition of Oxidative Damage, MAPKs, and NF-?B Pathways. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25770319&form=6&db=m Synergistic anti-tumor effects of melatonin and PUFAs from walnuts in a murine mammary adenocarcinoma model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25772694&form=6&db=m Meloxicam inhibits fipronil-induced apoptosis via modulation of the oxidative stress and inflammatory response in SH-SY5Y cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25773949&form=6&db=m Crosstalk between possible cytostatic and antiinflammatory potential of ketoprofen in the treatment of culture of colon and cervix cancer cell lines. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25776499&form=6&db=m The cancer pain related factors affected by celecoxib together with cetuximab in head and neck squamous cell carcinoma. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25781635&form=6&db=m Canolol inhibits gastric tumors initiation and progression through COX-2/PGE2 pathway in K19-C2mE transgenic mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25782035&form=6&db=m Ameliorative effects of Trichosanthes dioica Extract in suppressing inflammatory mediators and attenuating oxidative stress. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25783962&form=6&db=m A Role for the Inflammatory Mediators Cox-2 and Metalloproteinases in Cancer Stemness. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25787301&form=6&db=m Anti-oxidative and anti-inflammatory effects of Lobelia chinensis in vitro and in vivo. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25787879&form=6&db=m Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25792646&form=6&db=m Anti-inflammatory activity of the artificial antioxidants 2-tert-butyl-4-methoxyphenol (BHA), 2,6-di-tert-butyl-4-methylphenol (BHT) and 2,4,6-tri-tert-butylphenol (TBP), and their various combinations. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25793324&form=6&db=m Inhibition of chronic ulcerative colitis-associated adenocarcinoma development in mice by VSL#3. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25797267&form=6&db=m Ku80 cooperates with CBP to promote COX-2 expression and tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25798255&form=6&db=m Smoking-induced changes in cancer-related factors in patients with upper tract urothelial cancer. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25804702&form=6&db=m Inhibitory effect of the branches of Hovenia dulcis Thunb. and its constituent pinosylvin on the activities of IgE-mediated mast cells and passive cutaneous anaphylaxis in mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25807773&form=6&db=m [Markers for non-invasive molecular genetic diagnosis of oncourological diseases]. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25808797&form=6&db=m Modulatory effect of cadmium on the expression of phospholipase A2 and proinflammatory genes in rat testis. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25815878&form=6&db=m Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-?B and cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25821823&form=6&db=m Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25842298&form=6&db=m Chemopreventive effects of aspirin at a glance. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25843058&form=6&db=m N-trans-feruloyltyramine inhibits LPS-induced NO and PGE2 production in RAW 264.7 macrophages: Involvement of AP-1 and MAP kinase signalling pathways. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25849942&form=6&db=m Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25855137&form=6&db=m Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(?716) mice involves stromal COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25858511&form=6&db=m Antitumor immunostimulatory activity of polysaccharides from Salvia chinensis Benth. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25871313&form=6&db=m Red Bean Extract Inhibits Lipopolysaccharide-Induced Inflammation and H?O?-Induced Oxidative Stress in RAW 264.7 Macrophages. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25874230&form=6&db=m Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875558&form=6&db=m Coexpression of COX-2 and iNOS in Angiogenesis of Superficial Esophageal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881506&form=6&db=m Hypoxia potentiates tumor necrosis factor-? induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in white and brown adipocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25884412&form=6&db=m In vitro and in vivo anti-inflammatory activity of digested peptides derived from salmon myofibrillar protein conjugated with a small quantity of alginate oligosaccharide. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25886460&form=6&db=m Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25891025&form=6&db=m Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25894216&form=6&db=m Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25899770&form=6&db=m Low-dose chemotherapy with methotrexate and vinblastine for patients with desmoid tumors: relationship to CTNNB1 mutation status. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25900155&form=6&db=m Periodontal inflammation and alveolar bone loss induced by Aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25900875&form=6&db=m Polymorphisms in cyclooxygenase-2 gene in endometrial cancer patients. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25904117&form=6&db=m Toxicological Effect of Manganese on NF-?B/iNOS-COX-2 Signaling Pathway in Chicken Testes. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25906747&form=6&db=m The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25906749&form=6&db=m Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25907245&form=6&db=m The probiotic mixture IRT5 ameliorates age-dependent colitis in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25907560&form=6&db=m MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25908304&form=6&db=m A potential role of PUFAs and COXIBs in cancer chemoprevention. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25909170&form=6&db=m HSPA12B: a novel facilitator of lung tumor growth. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25913072&form=6&db=m ?-Chaconine isolated from a Solanum tuberosum L. cv Jayoung suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916654&form=6&db=m ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25917569&form=6&db=m Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25921160&form=6&db=m Sensitivity of gastric cancer cells to chemotherapy drugs in elderly patients and its correlation with cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25922506&form=6&db=m Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25926411&form=6&db=m Preventive and therapeutic effects of Lactobacillus paracasei B21060-based synbiotic treatment on gut inflammation and barrier integrity in colitic mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25937150&form=6&db=m Protective Roles of Selenium on Nitric Oxide and the Gene Expression of Inflammatory Cytokines Induced by Cadmium in Chicken Splenic Lymphocytes. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25939395&form=6&db=m Preclinical Pharmacokinetics and Pharmacodynamics and Content Analysis of Gnetol in Foodstuffs. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25949860&form=6&db=m Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25949900&form=6&db=m Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against ?? T cell cytotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25950450&form=6&db=m Mitogen-activated protein kinase phosphatase-1 prevents lipopolysaccharide-induced apoptosis in immature rat intestinal epithelial cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25951989&form=6&db=m A multi-targeted approach to suppress tumor-promoting inflammation. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25960826&form=6&db=m Effects of docosahexaenoic supplementation and in vitro vitamin C on the oxidative and inflammatory neutrophil response to activation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25961684&form=6&db=m The role of nutritional lipids and antioxidants in UV-induced skin cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25962348&form=6&db=m Cyclooxygenase-2 - An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25970082&form=6&db=m Targeted imaging of cancer by fluorocoxib C, a near-infrared cyclooxygenase-2 probe. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25972361&form=6&db=m Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973014&form=6&db=m Nephroblastoma overexpressed gene (NOV) enhances RCC cell motility through upregulation of ICAM-1 and COX-2 expression via Akt pathway. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973067&form=6&db=m Relationship of endothelial area with VEGF-A, COX-2, maspin, c-KIT, and DOG-1 immunoreactivity in liposarcomas versus non-lipomatous soft tissue tumors. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25986594&form=6&db=m Solid-State and Solution Characterization of Myricetin. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25988540&form=6&db=m Vascular endothelial function is improved by oral glycine treatment in aged rats. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26001729&form=6&db=m Histone acetyltransferase p300 is induced by p38MAPK after photodynamic therapy: the therapeutic response is increased by the p300HAT inhibitor anacardic acid. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26001832&form=6&db=m Heat stress-induced memory impairment is associated with neuroinflammation in mice. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26003084&form=6&db=m Anti-inflammatory effects of glaucocalyxin B in microglia cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26004412&form=6&db=m Proteases and their receptors as mediators of inflammation-associated colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26005470&form=6&db=m Immunohistochemical analysis of COX-2 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma: A comparative study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26007287&form=6&db=m DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26009874&form=6&db=m Mcl-1 is an important therapeutic target for oral squamous cell carcinomas. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26011096&form=6&db=m ?-Linolenic Fatty Acid Supplementation Decreases Tumor Growth and Cachexia Parameters in Walker 256 Tumor-Bearing Rats. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26011146&form=6&db=m Inhibition of 11?-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26012226&form=6&db=m Some studies on spontaneous Hymenolepis diminuta infection in laboratory rats. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26016441&form=6&db=m Lutein suppresses inflammatory responses through Nrf2 activation and NF-?B inactivation in lipopolysaccharide-stimulated BV-2 microglia. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26018088&form=6&db=m Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26018276&form=6&db=m [Compound K suppresses myeloid-derived suppressor cells in a mouse model bearing CT26 colorectal cancer xenograft]. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26020725&form=6&db=m The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26021821&form=6&db=m Glucagon induces airway smooth muscle relaxation by nitric oxide and prostaglandin E?. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26026079&form=6&db=m Combination Efficacy of Astragalus membranaceus and Curcuma wenyujin at Different Stages of Tumor Progression in an Imageable Orthotopic Nude Mouse Model of Metastatic Human Ovarian Cancer Expressing Red Fluorescent Protein. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26026393&form=6&db=m Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26027823&form=6&db=m 3?-Angeloyloxy-8?,10?-dihydroxyeremophila-7(11)-en-12,8?-lactone Inhibits Lipopolysaccharide-Induced Nitric Oxide Production in RAW264.7 Cells. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26034355&form=6&db=m Expression of COX-2 and HER-2 in colorectal cancer and their correlation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26035123&form=6&db=m Mucin 1 Regulates Cox-2 Gene in Pancreatic Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26036909&form=6&db=m The TLR-2/TLR-6 agonist macrophage-activating lipopeptide-2 augments human NK cell cytotoxicity when PGE2 production by monocytes is inhibited by a COX-2 blocker. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26041990&form=6&db=m Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer's disease: a pilot study. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26043379&form=6&db=m Anti-Inflammatory Activity of Haskap Cultivars is Polyphenols-Dependent. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26049169&form=6&db=m Tannic acid modulates NF?B signaling pathway and skin inflammation in NC/Nga mice through PPAR? expression. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26055124&form=6&db=m Red ginseng represses hypoxia-induced cyclooxygenase-2 through sirtuin1 activation. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26057147&form=6&db=m COX-2 induces lytic reactivation of EBV through PGE2 by modulating the EP receptor signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26059174&form=6&db=m Tamarind Seed (Tamarindus indica) Extract Ameliorates Adjuvant-Induced Arthritis via Regulating the Mediators of Cartilage/Bone Degeneration, Inflammation and Oxidative Stress. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26060153&form=6&db=m Relationship of CD95 and COX-2 in renal cell carcinomas with survival and other prognostic parameters: A tissue microarray study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26062514&form=6&db=m Antiinflammatory and Analgesic Activities of Ethanol Extract and Isolated Compounds from Millettia pulchra. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26062799&form=6&db=m The liver X receptor agonist TO901317 protects mice against cisplatin-induced kidney injury. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26067757&form=6&db=m Pro-migratory actions of the prostacyclin receptor in human breast cancer cells that over-express cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26069367&form=6&db=m A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26069486&form=6&db=m Effect of liposomal celecoxib on proliferation of colon cancer cell and inhibition of DMBA-induced tumor in rat model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26069953&form=6&db=m Combined Therapy with Rheum tanguticum Polysaccharide and Low-dose 5-ASA Ameliorates TNBS-Induced Colitis in Rats by Suppression of NF-?B. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26084155&form=6&db=m [Advance in studies on anti-cancer activity and mechanism of flavonoids]. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26089605&form=6&db=m Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26093472&form=6&db=m Odontoblastic Differentiation, Inflammatory Response, and Angiogenic Potential of 4 Calcium Silicate-based Cements: Micromega MTA, ProRoot MTA, RetroMTA, and Experimental Calcium Silicate Cement. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26096705&form=6&db=m Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-?B Pathways. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26100520&form=6&db=m Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26100521&form=6&db=m Omega-3-Acid Ethyl Esters Block the Protumorigenic Effects of Obesity in Mouse Models of Postmenopausal Basal-like and Claudin-Low Breast Cancer. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26100595&form=6&db=m Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26101342&form=6&db=m Activation of central PPAR-? attenuates angiotensin II-induced hypertension. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26101475&form=6&db=m Clinical significance of COX-2, GLUT-1 and VEGF expressions in endometrial cancer tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26107817&form=6&db=m Simultaneous inhibition of EGFR/VEGFR and cyclooxygenase-2 targets stemness-related pathways in colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26111272&form=6&db=m Intratumoral CD8+ Lymphocyte Infiltration as a Prognostic Factor and Its Relationship With Cyclooxygenase 2 Expression and Microsatellite Instability in Endometrial Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26111478&form=6&db=m Phospholipid Incorporation of Non-Methylene-Interrupted Fatty Acids (NMIFA) in Murine Microglial BV-2 Cells Reduces Pro-Inflammatory Mediator Production. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26114656&form=6&db=m Clarithromycin Attenuates Radiation-Induced Lung Injury in Mice. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26119957&form=6&db=m Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-?B Pathway in Mouse Peritoneal Macrophages. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26122280&form=6&db=m Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26124697&form=6&db=m The potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26125280&form=6&db=m Predictive value of Cyclooxygenase-2 over expression for identifying prostate cancer from benign prostatic hyperplasia in prostate biopsy specimens. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26131278&form=6&db=m Expression of matrix metalloproteinase-9, cyclooxygenase-2 and vascular endothelial growth factor are increased in gastrointestinal stromal tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26132605&form=6&db=m Potential clinical application of interleukin-27 as an antitumor agent. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26132856&form=6&db=m Oxysophocarpine Ameliorates Carrageenan-induced Inflammatory Pain via Inhibiting Expressions of Prostaglandin E2 and Cytokines in Mice. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26134824&form=6&db=m TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26136990&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and microRNA-143 in osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26142738&form=6&db=m In silico database screening of potential targets and pathways of compounds contained in plants used for psoriasis vulgaris. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26149990&form=6&db=m Protective effect of ginsenosides Rg1 and Re on lipopolysaccharide-induced sepsis by competitive binding to Toll-like receptor 4. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26152793&form=6&db=m Cyanidin-3-O-glucoside attenuates acute lung injury in sepsis rats. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26157065&form=6&db=m Inhibitory effects of Chikusetsusaponin IVa on lipopolysaccharide-induced pro-inflammatory responses in THP-1 cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26159723&form=6&db=m Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26165866&form=6&db=m Sodium Hydrosulfide Attenuates Beta-Amyloid-Induced Cognitive Deficits and Neuroinflammation via Modulation of MAPK/NF-?B Pathway in Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26166764&form=6&db=m miR-573 is a negative regulator in the pathogenesis of rheumatoid arthritis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26171676&form=6&db=m 5-Methoxytryptophan-dependent inhibition of oral squamous cell carcinoma metastasis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26180003&form=6&db=m Dual Cyclooxygenase and Carbonic Anhydrase Inhibition by Nonsteroidal Anti-Inflammatory Drugs for the Treatment of Cancer. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26180515&form=6&db=m Cyclooxygeanse-2 promotes metastasis in osteosarcoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26189710&form=6&db=m Influence of an n-3 long-chain polyunsaturated fatty acid-enriched diet on experimentally induced synovitis in horses. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26190920&form=6&db=m Acetyl Eburicoic Acid from Laetiporus sulphureus var. miniatus Suppresses Inflammation in Murine Macrophage RAW 264.7 Cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26193871&form=6&db=m New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26195278&form=6&db=m Low-grade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26199557&form=6&db=m Administration of red ginseng ameliorates memory decline in aged mice. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26201682&form=6&db=m Effects of Molybdenum or/and Cadmium on mRNA Expression Levels of Inflammatory Cytokines and HSPs in Duck Spleens. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26205049&form=6&db=m Anti-Inflammatory Activities of Licorice Extract and Its Active Compounds, Glycyrrhizic Acid, Liquiritin and Liquiritigenin, in BV2 Cells and Mice Liver. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26207152&form=6&db=m Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26216432&form=6&db=m Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26218314&form=6&db=m Expression and clinical implication of cyclooxygenase-2 and e-cadherin in oral squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26220282&form=6&db=m Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26227635&form=6&db=m The GPR55 antagonist CID16020046 protects against intestinal inflammation. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26236111&form=6&db=m ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26238650&form=6&db=m DNA-hypomethylating agent, 5'-azacytidine, induces cyclooxygenase-2 expression via the PI3-kinase/Akt and extracellular signal-regulated kinase-1/2 pathways in human HT1080 fibrosarcoma cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26243669&form=6&db=m Anti-inflammatory activity of polyphenolics from açai (Euterpe oleracea Martius) in intestinal myofibroblasts CCD-18Co cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26244515&form=6&db=m DNA Sequence Variants in the Five Prime Untranslated Region of the Cyclooxygenase-2 Gene Are Commonly Found in Healthy Dogs and Gray Wolves. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26251508&form=6&db=m Antiproliferative and anti-inflammatory properties of diindolylmethane and lupeol against N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis in experimental rats. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26256699&form=6&db=m Anti-inflammatory effects of vina-ginsenoside R2 and majonoside R2 isolated from Panax vietnamensis and their metabolites in lipopolysaccharide-stimulated macrophages. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26257064&form=6&db=m Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26257474&form=6&db=m Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26260258&form=6&db=m Guggulsterone Attenuated Lipopolysaccharide-Induced Inflammatory Responses in Mouse Inner Medullary Collecting Duct-3 Cells. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261008&form=6&db=m Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26261556&form=6&db=m JAK2/STAT3 pathway mediating inflammatory responses in heatstroke-induced rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26262998&form=6&db=m Influence of myeloperoxidase on colon tumor occurrence in inflamed versus non-inflamed colons of Apc(Min/+) mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26266054&form=6&db=m Withaferin A Inhibits Nuclear Factor-?B-Dependent Pro-Inflammatory and Stress Response Pathways in the Astrocytes. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26266403&form=6&db=m Anti-Inflammatory Activity of Heterocarpin from the Salt Marsh Plant Corydalis heterocarpa in LPS-Induced RAW 264.7 Macrophage Cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26269760&form=6&db=m Cyclooxygenase-2 knockdown using retinoic acid chalcone (RAC), a promising therapeutic strategy for colon cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26275572&form=6&db=m A window-of-opportunity biomarker study of etodolac in resectable breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26288481&form=6&db=m Anti-inflammatory activity of Nerium indicum by inhibition of prostaglandin E2 in murine splenic lymphocytes. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26290268&form=6&db=m Molecular Changes in Sub-lesional Muscle Following Acute Phase of Spinal Cord Injury. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26297443&form=6&db=m Anti-inflammatory and antinociceptive effects of racemic goniothalamin, a styryl lactone. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26300003&form=6&db=m Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26303353&form=6&db=m Does miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer? causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26308761&form=6&db=m Preclinical Studies Suggest Complex Nutraceutical Strategies May Have Potential for Preventing and Managing Sepsis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26310524&form=6&db=m Non Steroidal Anti Inflammatory Drugs As Gatekeepers Of Colon Carcinoma Highlight New Scenarios Beyond Cyclooxygenases Inhibition. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26317548&form=6&db=m Dietary prevention of Helicobacter pylori-associated gastric cancer with kimchi. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26323643&form=6&db=m Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26330537&form=6&db=m 2,5-Dimethyl-celecoxib inhibits cell cycle progression and induces apoptosis in human leukemia cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26332574&form=6&db=m Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26334245&form=6&db=m Expression of Phospholipase D in Periodontitis and Its Role in the Inflammatory and Osteoclastic Response by Nicotine- and Lipopolysaccharide-Stimulated Human Periodontal Ligament Cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26334317&form=6&db=m Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26336580&form=6&db=m Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339385&form=6&db=m Combined use of COX-1 and VEGF immunohistochemistry refines the histopathologic prognosis of renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26341413&form=6&db=m Phlorofucofuroeckol B suppresses inflammatory responses by down-regulating nuclear factor ?B activation via Akt, ERK, and JNK in LPS-stimulated microglial cells. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26342105&form=6&db=m IL-18-induced interaction between IMP3 and HuR contributes to COX-2 mRNA stabilization in acute myeloid leukemia. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26342572&form=6&db=m Sterols and triterpenoids as potential anti-inflammatories: Molecular docking studies for binding to some enzymes involved in inflammatory pathways. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26343742&form=6&db=m Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26347516&form=6&db=m Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26347954&form=6&db=m Antiproliferative activity of New Zealand propolis and phenolic compounds vs human colorectal adenocarcinoma cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26350254&form=6&db=m ?-Linolenic acid (ALA) is an anti-inflammatory agent in inflammatory bowel disease. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26359357&form=6&db=m Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26369614&form=6&db=m A functional progesterone receptor is required for immunomodulation, reduction of reactive gliosis and survival of oligodendrocyte precursors in the injured spinal cord. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26370797&form=6&db=m Sonicated Protein Fractions of Mycoplasma hyopneumoniae Induce Inflammatory Responses and Differential Gene Expression in a Murine Alveolar Macrophage Cell Line. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26373551&form=6&db=m Replication-competent adenoviruses with the type 35-derived fiber-knob region achieve reactive oxygen species-dependent cytotoxicity and produce greater toxicity than those with the type 5-derived region in pancreatic carcinoma. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26375521&form=6&db=m Cepharanthine mitigates pro-inflammatory cytokine response in lung injury induced by hemorrhagic shock/resuscitation in rats. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26376734&form=6&db=m Licarin A is a candidate compound for the treatment of immediate hypersensitivity via inhibition of rat mast cell line RBL-2H3 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26377664&form=6&db=m Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets? causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26390971&form=6&db=m Targeted therapies in bladder cancer: an overview of in vivo research. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26396142&form=6&db=m Vitamin D, Inflammation, and Colorectal Cancer Progression: A Review of Mechanistic Studies and Future Directions for Epidemiological Studies. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26400105&form=6&db=m Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26400710&form=6&db=m Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in experimental rat model. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26410343&form=6&db=m Olive oil compounds inhibit the paracrine regulation of TNF-?-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26411988&form=6&db=m Anti-inflammatory activity of horseradish (Armoracia rusticana) root extracts in LPS-stimulated macrophages. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26416248&form=6&db=m RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26416516&form=6&db=m Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26417707&form=6&db=m Inflammatory response and endothelial dysfunction in the hearts of mice co-exposed to SO2 , NO2 , and PM2.5. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26417933&form=6&db=m Nickel chloride (NiCl2)-caused inflammatory responses via activation of NF-?B pathway and reduction of anti-inflammatory mediator expression in the kidney. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26423123&form=6&db=m Extracellular Vesicles from Bovine Follicular Fluid Support Cumulus Expansion. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26424772&form=6&db=m Research Article Flavocoxid Protects Against Cadmium-Induced Disruption of the Blood-Testis Barrier and Improves Testicular Damage and Germ Cell Impairment in Mice. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26426828&form=6&db=m Thyroid Cancer and Nonsteroidal Anti-Inflammatory Drug Use: A Pooled Analysis of Patients Older Than 40 Years of Age. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26428849&form=6&db=m Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26429877&form=6&db=m Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26430963&form=6&db=m The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26431176&form=6&db=m Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26439596&form=6&db=m Protective effect of telmisartan treatment against arsenic-induced testicular toxicity in rats. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26440517&form=6&db=m Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26442202&form=6&db=m Targeting the COX-2 Pathway to Improve Therapeutic Response in the Obese Breast Cancer Patient Population. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26451317&form=6&db=m COX-2 promotes metastasis in nasopharyngeal carcinoma by mediating interactions between cancer cells and myeloid-derived suppressor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26452035&form=6&db=m Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26453508&form=6&db=m Catechin-7-O-?-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26456195&form=6&db=m Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26460079&form=6&db=m Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464629&form=6&db=m Low molecular weight heparin prevents lipopolysaccharide induced-hippocampus-dependent cognitive impairments in mice. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26464643&form=6&db=m Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 Level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26469068&form=6&db=m Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26469560&form=6&db=m Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26470710&form=6&db=m The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Proteins mRNA Expression in Chicken Livers. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26474585&form=6&db=m Coumarins from Angelica decursiva inhibit lipopolysaccharide-induced nitrite oxide production in RAW 264.7 cells. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26478101&form=6&db=m Maternal and fetal roles in bacterially induced preterm labor in the mouse. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26481188&form=6&db=m Blocking autophagy enhances meloxicam lethality to hepatocellular carcinoma by promotion of endoplasmic reticulum stress. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26493186&form=6&db=m Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26497591&form=6&db=m Bioactive peptide from Pyropia yezoensis and its anti-inflammatory activities. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26497721&form=6&db=m Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis? ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498465&form=6&db=m Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498950&form=6&db=m Minor salivary gland carcinoma: a review of 35 cases. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26508095&form=6&db=m Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26510880&form=6&db=m Ancient Chinese Formula Qiong-Yu-Gao Protects Against Cisplatin-Induced Nephrotoxicity Without Reducing Anti-tumor Activity. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26513295&form=6&db=m Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26518876&form=6&db=m Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26522475&form=6&db=m Apocynin protects against ethanol-induced gastric ulcer in rats by attenuating the upregulation of NADPH oxidases 1 and 4. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26523208&form=6&db=m Combination Treatment with Apricoxib and IL-27 Enhances Inhibition of Epithelial-Mesenchymal Transition in Human Lung Cancer Cells through a STAT1 Dominant Pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26523594&form=6&db=m Effects of oral meloxicam administration to beef cattle receiving lipopolysaccharide administration or vaccination against respiratory pathogens. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26530100&form=6&db=m Esophageal squamous cell carcinoma cell proliferation induced by exposure to low concentration of cigarette smoke extract is mediated via targeting miR-101-3p/COX-2 pathway. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26540449&form=6&db=m Protective Effect of Areca catechu Leaf Ethanol Extract Against Ethanol-Induced Gastric Ulcers in ICR Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26542776&form=6&db=m Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546527&form=6&db=m Radical-scavenging and Anti-inflammatory Activity of Quercetin and Related Compounds and Their Combinations Against RAW264.7 Cells Stimulated with Porphyromonas gingivalis Fimbriae. Relationships between Anti-inflammatory Activity and Quantum Chemical Parameters. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546721&form=6&db=m Inhibition of the interactions between metastatic human breast cancer cells and platelets by ?-nitrostyrene derivatives. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546977&form=6&db=m Bisphenol A-induced epithelial to mesenchymal transition is mediated by cyclooxygenase-2 up-regulation in human endometrial carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26548623&form=6&db=m Cyclooxygenase-2 inhibitors in lung cancer treatment: Bench to bed. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26549540&form=6&db=m Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26549987&form=6&db=m Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26550156&form=6&db=m Cyclooxygenase-2 -1195G>A (rs689466) polymorphism and cancer susceptibility: an updated meta-analysis involving 50,672 subjects. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26550460&form=6&db=m Upregulation of cyclooxygenase-2 is associated with activation of the alternative nuclear factor kappa B signaling pathway in colonic adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26551717&form=6&db=m Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26554780&form=6&db=m COX-2 Promotes Migration and Invasion by the Side Population of Cancer Stem Cell-Like Hepatocellular Carcinoma Cells. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26556721&form=6&db=m Schisandrin B Ameliorates ICV-Infused Amyloid ? Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-?B/MAPK and Up-Regulating HSP/Beclin Expression. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26557918&form=6&db=m Micro ribonucleic acid (RNA)-101 inhibits cell proliferation and invasion of lung cancer by regulating cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26561007&form=6&db=m Black Tea: Phytochemicals, Cancer Chemoprevention and Clinical Studies. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26561056&form=6&db=m Guggulsterone for Chemoprevention of Cancer. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26566186&form=6&db=m COX inhibitors: a patent review (2011 - 2014). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26571085&form=6&db=m DXXK exerts anti-inflammatory effects by inhibiting the lipopolysaccharide-induced NF-?B/COX-2 signalling pathway and the expression of inflammatory mediators. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26573710&form=6&db=m Inhibition of Brain Mitogen-Activated Protein Kinase Signaling Reduces Central Endoplasmic Reticulum Stress and Inflammation and Sympathetic Nerve Activity in Heart Failure Rats. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26575174&form=6&db=m Lymphadenectomy promotes tumor growth and cancer cell dissemination in the spontaneous RET mouse model of human uveal melanoma. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26576221&form=6&db=m Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26578177&form=6&db=m Perineural expression of high-mobility group box-1 contributes to long-lasting mechanical hypersensitivity via matrix metalloproteinase-9 upregulation in mice with painful peripheral neuropathy. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26581235&form=6&db=m The effects of Chamaecyparis obtusa essential oil on pain-related behavior and expression of pro-inflammatory cytokines in carrageenan-induced arthritis in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26590113&form=6&db=m Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26590503&form=6&db=m Aspirin and other non-steroidal anti-inflammatory drug prescriptions and survival after the diagnosis of head and neck and oesophageal cancer. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26592245&form=6&db=m Gene Microarray Analyses of Daboia russelli russelli Daboiatoxin Treatment of THP-1 Human Macrophages Infected with Burkholderia pseudomallei. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26592472&form=6&db=m Anti-inflammatory effects and antioxidant activity of dihydroasparagusic acid in lipopolysaccharide-activated microglial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26595378&form=6&db=m Timosaponin AIII inhibits melanoma cell migration by suppressing COX-2 and in vivo tumor metastasis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26597177&form=6&db=m Anti-tumor enhancement of Fei-Liu-Ping ointment in combination with celecoxib via cyclooxygenase-2-mediated lung metastatic inflammatory microenvironment in Lewis lung carcinoma xenograft mouse model. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26600514&form=6&db=m Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26601088&form=6&db=m An investigation of the rate of cyclooxygenase-2 expression on the surface of adenomatous and colorectal adenocarcinoma polyps. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26603374&form=6&db=m Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26604686&form=6&db=m The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26607068&form=6&db=m [Dual role of daphnetin in suppressing HMGB1 release and HMGB1-induced inflammation in murine macrophage RAW264.7 cells and human monocytic THP-1 cells in vitro]. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26608958&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 (COX-2) in oral nevi and melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26609171&form=6&db=m Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26609199&form=6&db=m Moringa oleifera Flower Extract Suppresses the Activation of Inflammatory Mediators in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via NF-?B Pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26611322&form=6&db=m Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26612085&form=6&db=m Antioxidant and anti-inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26618600&form=6&db=m Expression of Cyclooxygenase-2 in naturally occurring bovine cutaneous fibropapillomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622316&form=6&db=m Celecoxib for the prevention of nonmuscle invasive bladder cancer: results from a matched control study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26627481&form=6&db=m Artesunate Protects Against Sepsis-Induced Lung Injury Via Heme Oxygenase-1 Modulation. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26629939&form=6&db=m Inhibition of Glioblastoma Cell Growth In Vitro and In Vivo by Brucine, a Component of Chinese Medicine. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26632465&form=6&db=m [Expression and prognostic value of COX- 2, p16(INK4A) and p53 in patients with classical Hodgkin lymphoma]. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26634045&form=6&db=m Sonchus asper extract inhibits LPS-induced oxidative stress and pro-inflammatory cytokine production in RAW264.7 macrophages. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26638042&form=6&db=m Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26639845&form=6&db=m Glycyrrhiza glabra L. Extract Inhibits LPS-Induced Inflammation in RAW Macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26655637&form=6&db=m Anti-inflammatory and proapoptotic effects of umbelliferone in colon carcinogenesis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26660109&form=6&db=m Inhibitory Effect of Memantine on Streptozotocin-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Neurotrophic Factor Decline in Astrocytes. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26660326&form=6&db=m Ibuprofen abates cypermethrin-induced expression of pro-inflammatory mediators and mitogen-activated protein kinases and averts the nigrostriatal dopaminergic neurodegeneration. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26667466&form=6&db=m Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26675757&form=6&db=m HuR mediated post-transcriptional regulation as a new potential adjuvant therapeutic target in chemotherapy for pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680798&form=6&db=m Expression of Cyclooxygenase-2 in Human Breast Carcinoma: Relevance to Tumor Angiogenesis and Expression of Estrogen Receptor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680871&form=6&db=m Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680965&form=6&db=m Expression of Cyclooxygenase-2 and Tumor Microvessel Density in Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26682514&form=6&db=m Alterations in trace element levels and mRNA expression of Hsps and inflammatory cytokines in livers of duck exposed to molybdenum or/and cadmium. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691217&form=6&db=m Upregulation of cugbp2 increases response of pancreatic cancer cells to chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691871&form=6&db=m DJ-1 mutation decreases astroglial release of inflammatory mediators. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26707712&form=6&db=m Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26708200&form=6&db=m Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-?b signal pathways. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26712098&form=6&db=m Indomethacin derivatives as tubulin stabilizers to inhibit cancer cell proliferation. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26716648&form=6&db=m Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26723906&form=6&db=m Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26724476&form=6&db=m COX-2 inhibition attenuates lung injury induced by skeletal muscle ischemia reperfusion in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26724567&form=6&db=m Anti-neuroinflammatory effects of citreohybridonol involving TLR4-MyD88-mediated inhibition of NF-?B and MAPK signaling pathways in lipopolysaccharide-stimulated BV2 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26727596&form=6&db=m The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26728796&form=6&db=m Effect of Selenium Against Lead-Induced Damage on the Gene Expression of Heat Shock Proteins and Inflammatory Cytokines in Peripheral Blood Lymphocytes of Chickens. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26738987&form=6&db=m Anti-Inflammatory Effects of Ginsenoside-Rh2 Inhibits LPS-Induced Activation of Microglia and Overproduction of Inflammatory Mediators Via Modulation of TGF-?1/Smad Pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26739353&form=6&db=m Two COX-2 inhibitors induce apoptosis in human erythroleukemia K562cells by modulating NF-?B and FHC pathways. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26744410&form=6&db=m Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26744864&form=6&db=m MiR-26b suppresses tumor cell proliferation, migration and invasion by directly targeting COX-2 in lung cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26745386&form=6&db=m Tetrachlorobenzoquinone exhibits neurotoxicity by inducing inflammatory responses through ROS-mediated IKK/I?B/NF-?B signaling. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26756191&form=6&db=m Protective Effect of Ethanol Extracts of the Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes), on the Experimental Middle Cerebral Artery Occlusion/Reperfusion (MCAO/R) Model. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26756900&form=6&db=m COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26765787&form=6&db=m Morinda citrifolia edible leaf extract enhanced immune response against lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26769851&form=6&db=m Inhibition of breast cancer cell motility with a non-cyclooxygenase inhibitory derivative of sulindac by suppressing TGF?/miR-21 signaling. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26770028&form=6&db=m Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26770373&form=6&db=m Sulforaphane exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26774881&form=6&db=m hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26777972&form=6&db=m Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26791786&form=6&db=m Cyclooxygenase-2 (COX2) and p53 protein expression are interdependent in breast cancer but not associated with clinico-pathological surrogate subtypes, tumor aggressiveness and patient survival. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26791964&form=6&db=m Clinical relevance of cyclo-oxygenase 2 and peroxisome proliferator activated receptor ? in eyelid sebaceous gland carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26792550&form=6&db=m High COX-2 expression is associated with increased angiogenesis, proliferation and tumoural inflammatory infiltrate in canine malignant mammary tumours: a multivariate survival study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26793111&form=6&db=m Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26801201&form=6&db=m Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26802941&form=6&db=m Apigenin inhibits COX-2, PGE2, and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808646&form=6&db=m Hazelnut and neuroprotection: Improved memory and hindered anxiety in response to intra-hippocampal A? injection. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26815166&form=6&db=m Accessible Method for the Development of Novel Sterol Analogues with Dipeptide-like Side Chains That Act as Neuroinflammation Inhibitors. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26817629&form=6&db=m Vitamin D mitigates the adverse effects of obesity on breast cancer in mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26817996&form=6&db=m Synergistic COX2 Induction by IFN? and TNF? Self-Limits Type-1 Immunity in the Human Tumor Microenvironment. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26821579&form=6&db=m Lipopolysaccharide Delays Closure of the Rat Ductus Arteriosus by Induction of Inducible Nitric Oxide Synthase But Not Prostaglandin E2. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26822118&form=6&db=m Synergistic growth inhibitory effect of deracoxib with doxorubicin against a canine mammary tumor cell line, CMT-U27. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26823679&form=6&db=m Repurposing Drugs in Oncology (ReDO)-diclofenac as an anti-cancer agent. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26824492&form=6&db=m TNF? up-regulates COX-2 in chronic progressive nephropathy through nuclear accumulation of RelB and NF-?B2. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26825466&form=6&db=m Cadherins: The Superfamily Critically Involved in Breast Cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26831653&form=6&db=m The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Protein mRNA Level in Chicken Cartilage Tissue. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26852953&form=6&db=m A tetramethoxychalcone from Chloranthus henryi suppresses lipopolysaccharide-induced inflammatory responses in BV2 microglia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26853158&form=6&db=m Targeting arachidonic acid pathway by natural products for cancer prevention and therapy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26853745&form=6&db=m Effects of volatile oils of Angelica sinensis on an acute inflammation rat model. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26859139&form=6&db=m Anti-Inflammatory and Antioxidant Actions of N-Arachidonoyl Serotonin in RAW264.7 Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26869831&form=6&db=m Protective effect of wild ginseng cambial meristematic cells on d-galactosamine-induced hepatotoxicity in rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870226&form=6&db=m Sinomenine, a COX-2 inhibitor, induces cell cycle arrest and inhibits growth of human colon carcinoma cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870269&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and interleukin-32 in primary gastric B-cell lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26872318&form=6&db=m Neonatal exposure to estradiol-17? modulates tumour necrosis factor alpha and cyclooxygenase-2 expression in brain and also in ovaries of adult female rats. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26876356&form=6&db=m Heat-killed whole-cell products of the probiotic Pseudomonas aeruginosa VSG2 strain affect in vitro cytokine expression in head kidney macrophages of Labeo rohita. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26878795&form=6&db=m Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-?B signaling. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881046&form=6&db=m Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26881519&form=6&db=m Cyclooxygenase-2 expression is associated with elevated aspartate aminotransferase level in hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26883667&form=6&db=m Metabolic and molecular relative percentage coreduction in patients with locally advanced rectal cancer treated with neoadjuvant therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,1,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26893662&form=6&db=m Paeoniflorin ameliorates rheumatoid arthritis in rat models through oxidative stress, inflammation and cyclooxygenase 2. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26898448&form=6&db=m Chemopreventive action of non-steroidal anti-inflammatory drugs on the inflammatory pathways in colon cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26909300&form=6&db=m The SK-N-AS human neuroblastoma cell line develops osteolytic bone metastases with increased angiogenesis and COX-2 expression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26917230&form=6&db=m A Sensitive NanoString-Based Assay to Score STK11 (LKB1) Pathway Disruption in Lung Adenocarcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26920155&form=6&db=m Cyclooxygenase 2 (rs2745557) Polymorphism and the Susceptibility to Benign Prostate Hyperplasia and Prostate Cancer in Egyptians. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26923293&form=6&db=m Targeted CFTR gene disruption with zinc-finger nucleases in human intestinal epithelial cells induces oxidative stress and inflammation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26925639&form=6&db=m COX-2 Expression in Renal Cell Carcinoma and Correlations with Tumor Grade, Stage and Patient Prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26929574&form=6&db=m Anti-inflammatory, Anti-estrogenic, and Anti-implantation Activity of Bergia suffruticosa (Delile) Fenzl. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26929999&form=6&db=m Photo-protective activity of pogostone against UV-induced skin premature aging in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26930569&form=6&db=m Effect of NSAIDs on the aminopeptidase activity of cultured human osteoblasts. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931732&form=6&db=m ?-Solanine Isolated from Solanum tuberosum L. cv Jayoung Abrogates LPS-Induced Inflammatory Responses via NF-?B Inactivation in RAW 264.7 Macrophages and Endotoxin-Induced Shock Model in Mice. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26934842&form=6&db=m Aqueous Terminalia arjuna extract modulates expression of key atherosclerosis-related proteins in a hypercholesterolemic rabbit: A proteomic-based study. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26955911&form=6&db=m The use of cyclooxygenase-2 inhibitors for improvement of efficacy of radiotherapy in cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26957558&form=6&db=m MicroRNA MIR21 (miR-21) and PTGS2 expression in colorectal cancer and patient survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959112&form=6&db=m Radiation therapy generates platelet-activating factor agonists. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959737&form=6&db=m MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26961887&form=6&db=m (7R,8S)-Dehydrodiconiferyl Alcohol Suppresses Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglia by Inhibiting MAPK Signaling. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26969386&form=6&db=m Methyl syringate, a TRPA1 agonist represses hypoxia-induced cyclooxygenase-2 in lung cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970125&form=6&db=m Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26970604&form=6&db=m Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26973239&form=6&db=m Angiopoietin-Like Protein 7 Promotes an Inflammatory Phenotype in RAW264.7 Macrophages Through the P38 MAPK Signaling Pathway. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26984380&form=6&db=m Regulation of COX-2 expression and epithelial-to-mesenchymal transition by hypoxia-inducible factor-1? is associated with poor prognosis in hepatocellular carcinoma patients post TACE surgery. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26994999&form=6&db=m Hesperetin Suppresses Inflammatory Responses in Lipopolysaccharide-Induced RAW 264.7 Cells via the Inhibition of NF-?B and Activation of Nrf2/HO-1 Pathways. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27000374&form=6&db=m COX-2 modulates mammary tumor progression in response to collagen density. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27012907&form=6&db=m Correlation Between Cyclo-oxygenase-2 and Vascular Endothelial Growth Factor Expression in Canine and Feline Squamous Cell Carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27013544&form=6&db=m Detection of inflammatory biomarkers in saliva and urine: Potential in diagnosis, prevention, and treatment for chronic diseases. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27016075&form=6&db=m Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27023525&form=6&db=m The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO). diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27025382&form=6&db=m An analysis on the suppression of NO and PGE2 by diphenylheptane A and its effect on glycerophospholipids of lipopolysaccharide-induced RAW264.7 cells with UPLC/ESI-QTOF-MS. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27034602&form=6&db=m Inhibition of Pro-inflammatory Mediators and Cytokines by Chlorella Vulgaris Extracts. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27041864&form=6&db=m Protective Mechanisms of Thymoquinone on Methotrexate-induced Intestinal Toxicity in Rats. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27043768&form=6&db=m Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27044806&form=6&db=m Fish oil augments celecoxib mediated alteration in apoptotic pathway in the initiation phase of 7,12-dimethylbenz(?)anthracene-induced mammary carcinogenesis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27045033&form=6&db=m Elevated Levels of Urinary PGE-M Are Found in Tobacco Users and Indicate a Poor Prognosis for Oral Squamous Cell Carcinoma Patients. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27045576&form=6&db=m Clinical value of intratumoral metabolic heterogeneity in [18F]FDG PET/CT for prediction of recurrence in patients with locally advanced colorectal cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27049555&form=6&db=m PGE2 released by primary sensory neurons modulates Toll-like receptor 4 activities through an EP4 receptor-dependent process. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27053204&form=6&db=m Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27057306&form=6&db=m Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27057441&form=6&db=m TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058519&form=6&db=m Wild Bitter Melon Leaf Extract Inhibits Porphyromonas gingivalis-Induced Inflammation: Identification of Active Compounds through Bioassay-Guided Isolation. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058626&form=6&db=m Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27062228&form=6&db=m Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27065336&form=6&db=m Semaphorin 7a exerts pleiotropic effects to promote breast tumor progression. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27070323&form=6&db=m Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27074574&form=6&db=m Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27074576&form=6&db=m The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27076745&form=6&db=m Quantitative Analysis and In vitro Anti-inflammatory Effects of Gallic Acid, Ellagic Acid, and Quercetin from Radix Sanguisorbae. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27078846&form=6&db=m mTORC1-mediated downregulation of COX2 restrains tumor growth caused by TSC2 deficiency. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27079437&form=6&db=m Inflammation in gastric cancer: Interplay of the COX-2/prostaglandin E2 and Toll-like receptor/MyD88 pathways. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27086154&form=6&db=m Fruits extracts of Hovenia dulcis Thunb. suppresses lipopolysaccharide-stimulated inflammatory responses through nuclear factor-kappaB pathway in Raw 264.7 cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27086487&form=6&db=m Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27090925&form=6&db=m Anti-inflammatory activity of ?-patchoulene isolated from patchouli oil in mice. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27091559&form=6&db=m Protective effects of Weilikang decoction on gastric ulcers and possible mechanisms. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27101738&form=6&db=m Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-?-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27104573&form=6&db=m Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy-A Hypothesis-Driven Review. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27105172&form=6&db=m Investigating associations of cyclooxygenase-2 expression with angiogenesis, proliferation, macrophage and T-lymphocyte infiltration in canine melanocytic tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27107700&form=6&db=m Hypothermia followed by rapid rewarming exacerbates ischemia-induced brain injury and augments inflammatory response in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27109804&form=6&db=m Meloxicam suppresses hepatocellular carcinoma cell proliferation and migration by targeting COX-2/PGE2-regulated activation of the ?-catenin signaling pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27109920&form=6&db=m Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27111520&form=6&db=m Sophoraflavanone G prevents Streptococcus mutans surface antigen I/II-induced production of NO and PGE2 by inhibiting MAPK-mediated pathways in RAW 264.7 macrophages. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27111555&form=6&db=m COX-1 Inhibitors: Beyond Structure Toward Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27112768&form=6&db=m PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27114638&form=6&db=m Anti-inflammatory and anti-granuloma activity of Berberis aristata DC. in experimental models of inflammation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27121716&form=6&db=m Recent Developments in Chimeric NSAIDs as Anticancer Agents: Teaching an Old Dog a New Trick. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27128654&form=6&db=m Novel synthetic curcumin analogs as potent antiangiogenic agents in colorectal cancer. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27139571&form=6&db=m Anti-inflammatory and anti-oxidant effect of Calea urticifolia lyophilized aqueous extract on lipopolysaccharide-stimulated RAW 264.7 macrophages. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145282&form=6&db=m Inhibition of cancer cell epithelial mesenchymal transition by normal fibroblasts via production of 5-methoxytryptophan. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27145850&form=6&db=m Influencing COX-2 activity by COX related pathways in inflammation and cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27146587&form=6&db=m Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27159630&form=6&db=m Synthesis of Resveratrol Derivatives and In Vitro Screening for Potential Cancer Chemopreventive Activities. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27164411&form=6&db=m Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27169820&form=6&db=m Vaccinium bracteatum Thunb. Exerts Anti-Inflammatory Activity by Inhibiting NF-?B Activation in BV-2 Microglial Cells. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27170516&form=6&db=m Anti-inflammatory Effects of Novel Polysaccharide Sacran Extracted from Cyanobacterium Aphanothece sacrum in Various Inflammatory Animal Models. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27172930&form=6&db=m PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27173352&form=6&db=m Functional polymorphisms of the cyclooxygenase-2 gene and prognosis of hepatocellular carcinoma - a cohort study in Chinese people. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27176787&form=6&db=m Suppressive effects of a proton beam on tumor growth and lung metastasis through the inhibition of metastatic gene expression in 4T1 orthotopic breast cancer model. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27177216&form=6&db=m Correlation between angiogenic/inflammatory mediators in Wister rat model of liver dysplasia. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27178629&form=6&db=m Src/Syk/IRAK1-targeted anti-inflammatory action of Torreya nucifera butanol fraction in lipopolysaccharide-activated RAW264.7 cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27180880&form=6&db=m Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27186121&form=6&db=m Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27198692&form=6&db=m Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27210423&form=6&db=m Indomethacin sensitizes resistant transformed cells to macrophage cytotoxicity. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27216189&form=6&db=m YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2-EGFR Signaling Axis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27219011&form=6&db=m Mangiferin: A xanthonoid with multipotent anti-inflammatory potential. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27221835&form=6&db=m Celecoxib, a COX-2 Selective Inhibitor, Induces Cell Cycle Arrest at the G2/M Phase in HeLa Cervical Cancer Cells. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27226186&form=6&db=m Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27228272&form=6&db=m Electromagnetic Field Devices and Their Effects on Nociception and Peripheral Inflammatory Pain Mechanisms. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27231478&form=6&db=m Virtual Dual inhibition of COX-2 / 5-LOX enzymes based on binding properties of alpha-amyrins, the anti-inflammatory compound as a promising anti-cancer drug. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27247720&form=6&db=m Anti-inflammatory effects of proanthocyanidin-rich red rice extract via suppression of MAPK, AP-1 and NF-?B pathways in Raw 264.7 macrophages. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27251985&form=6&db=m The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27256676&form=6&db=m Inhibitory effect of Gardenblue blueberry (Vaccinium ashei Reade) anthocyanin extracts on lipopolysaccharide-stimulated inflammatory response in RAW 264.7 cells. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27257388&form=6&db=m Upregulation of Cyclooxygenase-2/Prostaglandin E2 (COX-2/PGE2) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259813&form=6&db=m Celecoxib promotes degranulation of CD8(+) T cells in HPV-induced lesions of K14-HPV16 transgenic mice. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27261558&form=6&db=m Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-?B and JNK/p38 MAPK signaling pathways. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27262506&form=6&db=m Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells. diagnostic usage,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27268917&form=6&db=m Knockdown of 14-kDa phosphohistidine phosphatase expression suppresses lung cancer cell growth in vivo possibly through inhibition of NF-?B signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27279714&form=6&db=m Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27282666&form=6&db=m Anti-inflammatory and immunomodulatory effects of Critonia aromatisans leaves: Downregulation of pro-inflammatory cytokines. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27284355&form=6&db=m Sitagliptin attenuates in?ammatory responses in lipopolysaccharide-stimulated cardiomyocytes via nuclear factor-?B pathway inhibition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27287478&form=6&db=m Hepatic radiofrequency ablation: markedly reduced systemic effects by modulating periablational inflammation via cyclooxygenase-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27289249&form=6&db=m The role of aspirin in colorectal cancer chemoprevention. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27292107&form=6&db=m Augmented Activity of Cyclooxygenase-2 in Tissue and Serum of Patients With Cervical Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27293987&form=6&db=m Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27298502&form=6&db=m 5,7-dihydroxy-2-(3-hydroxy-4, 5-dimethoxy-phenyl)-chromen-4-one-a flavone from Bruguiera gymnorrhiza displaying anti-inflammatory properties. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27307703&form=6&db=m Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27313094&form=6&db=m Progressive loss of nigrostriatal dopaminergic neurons induced by inflammatory responses to fipronil. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314294&form=6&db=m Clinical and prognosis relevance of COX-2 expression in Tunisian patients with primary gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314329&form=6&db=m Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27316386&form=6&db=m No significant effects of Poly(I:C) on human umbilical cord-derived mesenchymal stem cells in the treatment of B6.MRL-Fas(lpr) mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27322717&form=6&db=m Neoadjuvant Treatment With Cyclooxygenase-2 Inhibitor and Prednisolone Allows Conservative Surgery for Inflammatory Myofibroblastic Tumor of the Bladder. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27323811&form=6&db=m Clinicopathological and prognostic significance of cyclooxygenase-2 expression in head and neck cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27333954&form=6&db=m Date syrup-derived polyphenols attenuate angiogenic responses and exhibits anti-inflammatory activity mediated by vascular endothelial growth factor and cyclooxygenase-2 expression in endothelial cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27337494&form=6&db=m Granulocyte-macrophage colony-stimulating factor (GM-CSF) is released by female mouse bladder urothelial cells and expressed by the urothelium as an early response to lipopolysaccharides (LPS). diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27338711&form=6&db=m Benzo(a)pyrene induces oxidative stress, pro-inflammatory cytokines, expression of nuclear factor-kappa B and deregulation of wnt/beta-catenin signaling in colons of BALB/c mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27342370&form=6&db=m Expression of cyclooxygenase 2 and vascular endothelial growth factor in gastric carcinoma: Relationship with clinicopathological parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27343699&form=6&db=m Stauntoside B inhibits macrophage activation by inhibiting NF-?B and ERK MAPK signalling. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27344640&form=6&db=m Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27349331&form=6&db=m Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27357268&form=6&db=m HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27367679&form=6&db=m Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27368132&form=6&db=m Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ?-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27375620&form=6&db=m Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27377395&form=6&db=m Adjuvant therapy for highly malignant canine mammary tumours: Cox-2 inhibitor versus chemotherapy: a case-control prospective study. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27377703&form=6&db=m Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27381829&form=6&db=m K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27382672&form=6&db=m [Expression of p53, p21, PCNA and COX-2 and its relationship with recurrence in the early-stage laryngeal cancer with negative surgical margin]. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27383140&form=6&db=m Pyrimidine-based fluorescent COX-2 inhibitors: synthesis and biological evaluation. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27384052&form=6&db=m Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27386631&form=6&db=m Effects of Cyclooxygenase on the Urothelium of the Urinary Bladder of Mice Exposed to Pelvic Radiation. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27388564&form=6&db=m The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27391144&form=6&db=m Intratumoral expression of cyclooxygenase-2 (COX-2) is a negative prognostic marker for patients with cutaneous melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27393434&form=6&db=m Protective potential of the methanol extract of Macrothelypteris oligophlebia rhizomes for chronic non-bacterial prostatitis in rats. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27394940&form=6&db=m Isolation and characterization of anti-inflammatory peptides derived from whey protein. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27394986&form=6&db=m Protective effect of gentiopicroside against dextran sodium sulfate induced colitis in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27396870&form=6&db=m Three Novel Alkaloids from Portulaca oleracea L. and Their Anti-inflammatory Effects. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27401288&form=6&db=m In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27403965&form=6&db=m Inhibition of precancerous lesions development in kidneys by chrysin via regulating hyperproliferation, inflammation and apoptosis at pre clinical stage. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27420055&form=6&db=m BML-111 Protected LPS/D-GalN-Induced Acute Liver Injury in Rats. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27420353&form=6&db=m Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27420617&form=6&db=m [The connection of miR-21 and miR-155 with regulation of 15-HPGDH mRNA in human breast cancer cells]. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27430377&form=6&db=m Celecoxib suppresses fibroblast growth factor-2 expression in pancreatic ductal adenocarcinoma PANC-1 cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27436928&form=6&db=m Impact of cyclooxygenase-2 over-expression on the prognosis of breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446381&form=6&db=m Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27447568&form=6&db=m Disruption of tumour-host communication by downregulation of LFA-1 reduces COX-2 and e-NOS expression and inhibits brain metastasis growth. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27448956&form=6&db=m The co-induced effects of molybdenum and cadmium on the mRNA expression of inflammatory cytokines and trace element contents in duck kidneys. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27450326&form=6&db=m Cleavage and polyadenylation specific factor 4 targets NF-?B/cyclooxygenase-2 signaling to promote lung cancer growth and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27450394&form=6&db=m Complete remission of pancreatic head desmoid tumor treated by COX-2 inhibitor-a case report. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27463712&form=6&db=m Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27466499&form=6&db=m Expression of Endoglin and Vascular Endothelial Growth Factor as Prognostic Markers in Experimental Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27467936&form=6&db=m Reducing prostaglandin E2 production to raise cancer immunogenicity. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27472313&form=6&db=m Corynoline Isolated from Corydalis bungeana Turcz. Exhibits Anti-Inflammatory Effects via Modulation of Nfr2 and MAPKs. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27474068&form=6&db=m Anti-inflammatory effects of 6'-O-acetyl mangiferin from Iris rossii Baker via NF-?b signal blocking in lipopolysaccharide-stimulated RAW 264.7 cells. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27474951&form=6&db=m Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27475305&form=6&db=m Regular Aspirin Use Associates with Lower Risk of Colorectal Cancers With Low Numbers of Tumor-infiltrating Lymphocytes. causal interaction,diagnostic usage,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27475881&form=6&db=m Hydrogen sulfide-releasing anti-inflammatory drugs for chemoprevention and treatment of cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27485489&form=6&db=m Structural characterization, molecular modification and hepatoprotective effect of melanin from Lachnum YM226 on acute alcohol-induced liver injury in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27494631&form=6&db=m Inducible Nitric Oxide Synthase (NOS2) in the Carcinogenesis of Gastrointestinal Cancers. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27494851&form=6&db=m Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27496879&form=6&db=m Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27497882&form=6&db=m Neuroprotective effects of Kaempferide-7-O-(4?-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27498419&form=6&db=m Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27512995&form=6&db=m Thrombomodulin Influences the Survival of Patients with Non-Metastatic Colorectal Cancer through Epithelial-To-Mesenchymal Transition (EMT). causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27516212&form=6&db=m 2-(4-{2-[(phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide as a new lead compound for management of allergic rhinitis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27521747&form=6&db=m Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27527191&form=6&db=m The Algal Meroterpene 11-Hydroxy-1'-O-Methylamentadione Ameloriates Dextran Sulfate Sodium-Induced Colitis in Mice. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27528223&form=6&db=m Suppressed Helicobacter pylori-associated gastric tumorigenesis in Fat-1 transgenic mice producing endogenous ?-3 polyunsaturated fatty acids. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27530115&form=6&db=m Chemical Constituents Identified from Fruit Body of Cordyceps bassiana and Their Anti-Inflammatory Activity. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27530354&form=6&db=m Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27534446&form=6&db=m Flavonoids Isolated from Flowers of Lonicera japonica Thunb. Inhibit Inflammatory Responses in BV2 Microglial Cells by Suppressing TNF-? and IL-? Through PI3K/Akt/NF-kb Signaling Pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27539609&form=6&db=m Isoliquiritigenin suppresses tumor necrosis factor-?-induced inflammation via peroxisome proliferator-activated receptor-? in intestinal epithelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27543936&form=6&db=m Inhibition of Macrophage Migration Inhibitory Factor (MIF) tautomerase activity suppresses Microglia-mediated inflmmatory responses. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27548215&form=6&db=m Post-Intake of S-Ethyl Cysteine and S-Methyl Cysteine Improved LPS-Induced Acute Lung Injury in Mice. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27554763&form=6&db=m Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27555783&form=6&db=m miR-203 is involved in the laryngeal carcinoma pathogenesis via targeting VEGFA and Cox-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27558792&form=6&db=m DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27559271&form=6&db=m Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27562319&form=6&db=m Cerbera manghas methanol extract exerts anti-inflammatory activity by targeting c-Jun N-terminal kinase in the AP-1 pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27570080&form=6&db=m Transcriptional regulation of mPGES1 in Cancer: an alternative approach to drug discovery? causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27577989&form=6&db=m Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27583979&form=6&db=m Attenuation of atherosclerotic complications by modulating inflammatory responses in hypercholesterolemic rats with dietary Njavara rice bran oil. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27588346&form=6&db=m Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590647&form=6&db=m [Neoadiuvant teleradiotherapy decreases cancer tissue and serum concentration of prostaglandin E2 and cyclooxygenase-2 expression in patients with rectal cancer]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27591442&form=6&db=m [Neoadiuvant teleradiotherapy decreases cancer tissue and serum concentration of prostaglandin E2 and cyclooxygenase-2 expression in patients with rectal cancer]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27602398&form=6&db=m In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27609291&form=6&db=m Glioma-secreted soluble factors stimulate microglial activation: The role of interleukin-1? and tumor necrosis factor-?. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27610157&form=6&db=m Design, Synthesis and Biological Evaluation of4-(Imidazolylmethyl)-2-(4-methylsulfonyl phenyl)-Quinoline Derivatives as Selective COX-2 Inhibitors and In-vitro Anti-breast Cancer Agents. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27619024&form=6&db=m The suppressive effects of metformin on inflammatory response of otitis media model in human middle ear epithelial cells. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27623131&form=6&db=m The Combined Blockade of ?-Adrenoceptor and COX-2 During the Perioperative Period to Improve Long-term Cancer Outcomes. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27625036&form=6&db=m Adelmidrol, a palmitoylethanolamide analogue, as a new pharmacological treatment for the management of inflammatory bowel disease. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27628320&form=6&db=m Studies on the Contribution of Cox-2 Expression in the Progression of Oral Squamous Cell Carcinoma and H-Ras Activation. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27632554&form=6&db=m The prognostic impact of COX-2 expression in breast cancer depends on oral contraceptive history, preoperative NSAID use, and tumor size. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27636508&form=6&db=m Atractylone, an active constituent of KMP6, attenuates allergic inflammation on allergic rhinitis in vitro and in vivo models. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27642319&form=6&db=m Celecoxib Treatment Alters p53 and MDM2 Expression via COX-2 Crosstalk in A549 Cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27645552&form=6&db=m Celecoxib suppresses autophagy and enhances cytotoxicity of imatinib in imatinib-resistant chronic myeloid leukemia cells. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27648736&form=6&db=m Anti-inflammatory Potential of Quercetin-3-O-?-D-("2"-galloyl)-glucopyranoside and Quercetin Isolated from Diospyros kaki calyx via Suppression of MAP Signaling Molecules in LPS-induced RAW 264.7 Macrophages. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27649238&form=6&db=m Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27654511&form=6&db=m Cyclooxygenase-2 induced ?1-integrin expression in NSCLC and promoted cell invasion via the EP1/MAPK/E2F-1/FoxC2 signal pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27654707&form=6&db=m Protective Role of Corilagin on A?25-35-Induced Neurotoxicity: Suppression of NF-?B Signaling Pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27661110&form=6&db=m Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27666139&form=6&db=m Celecoxib enhances the inhibitory effect of 5-FU on human squamous cell carcinoma proliferation by ROS production. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27669317&form=6&db=m Tart Cherry Extracts Reduce Inflammatory and Oxidative Stress Signaling in Microglial Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27677075&form=6&db=m Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27682182&form=6&db=m Beneficial Effects of Exogenous Melatonin in Acute Staphylococcus aureus and Escherichia coli Infection-Induced Inflammation and Associated Behavioral Response in Mice After Exposure to Short Photoperiod. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27693742&form=6&db=m A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27694039&form=6&db=m The effects of konjac oligosaccharide on TNBS-induced colitis in rats. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27695503&form=6&db=m Prognostic significance of cyclooxygenase-2 expression in patients with hepatocellular carcinoma: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27696591&form=6&db=m Inflammation-induced myeloid-derived suppressor cells associated with squamous cell carcinoma of the head and neck. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27697529&form=6&db=m Cox-2 promotes mesenchymal stem cells differentiation into cardiocytes by activating JNK and ERK pathway. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27698799&form=6&db=m Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27710895&form=6&db=m CD200Fc attenuates inflammatory responses and maintains barrier function by suppressing NF-?B pathway in cigarette smoke extract induced endothelial cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713126&form=6&db=m 18?-glycyrrhetinic acid suppresses gastric cancer by activation of miR-149-3p-Wnt-1 signaling. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713322&form=6&db=m NSAIDs: Old Drugs Reveal New Anticancer Targets. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27713364&form=6&db=m Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27718123&form=6&db=m PPAR? regulates inflammatory reaction by inhibiting the MAPK/NF-?B pathway in C2C12 skeletal muscle cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27733198&form=6&db=m Gyeji-tang water extract exerts anti-inflammatory activity through inhibition of ERK and NF-?B pathways in lipopolysaccharide-stimulated RAW 264.7 cells. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27733273&form=6&db=m Gomisin N ameliorates lipopolysaccharide-induced depressive-like behaviors by attenuating inflammation in the hypothalamic paraventricular nucleus and central nucleus of the amygdala in mice. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27738494&form=6&db=m ADAM17 in tumor associated leukocytes regulates inflammatory mediators and promotes mammary tumor formation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27739311&form=6&db=m [Prognostic and Predictive Factors for Pancreatic Adenocarcinoma]. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27746698&form=6&db=m unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27748297&form=6&db=m Association of organochlorine pesticides with the mRNA expression of tumour necrosis factor-alpha ( diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27769779&form=6&db=m Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27777130&form=6&db=m ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27789944&form=6&db=m Increased survival rate by local release of diclofenac in a murine model of recurrent oral carcinoma. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27790461&form=6&db=m In vivo and In vitro Anti-Inflammatory Activity of Indazole and Its Derivatives. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27798865&form=6&db=m Co-treatment with Celecoxib or NS398 Strongly Sensitizes Resistant Cancer Cells to Antimitotic Drugs Independent of P-gp Inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27803450&form=6&db=m Olmesartan Prevented Intra-articular Inflammation Induced by Zymosan in Rats. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27818595&form=6&db=m Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27822172&form=6&db=m Anti-inflammatory effect of supercritical extract and its constituents from Ishige okamurae. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27824617&form=6&db=m Tumor-associated macrophages induce vasculogenic mimicry of glioblastoma multiforme through cyclooxygenase-2 activation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27835884&form=6&db=m Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27854106&form=6&db=m Expression of cyclooxygenase-2 has no impact on survival in adenocarcinoma of the esophagogastric junction but is associated with favourable clinicopathologic features. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27860453&form=6&db=m Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27867272&form=6&db=m Oryza sativa (Rice) Hull Extract Inhibits Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages by Suppressing Extracellular Signal-regulated Kinase, c-Jun N-terminal Kinase, and Nuclear Factor-?B Activation. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27871154&form=6&db=m Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-?B and Inflammation Response. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27878500&form=6&db=m Anti-inflammatory and antioxidant effect of Kerabala: a value-added ayurvedic formulation from virgin coconut oil inhibits pathogenesis in adjuvant-induced arthritis. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27880817&form=6&db=m Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27882058&form=6&db=m Cyclooxygenase-2: A Role in Cancer Stem Cell Survival and Repopulation of Cancer Cells during Therapy. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27884749&form=6&db=m Celecoxib exerts antitumor effects in HL-60 acute leukemia cells and inhibits autophagy by affecting lysosome function. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27889107&form=6&db=m Combination of the anthocyanidins malvidin and peonidin attenuates lipopolysaccharide-mediated inflammatory gene expression in primary human adipocytes. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27889907&form=6&db=m Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27890971&form=6&db=m Veronicastrum axillare Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Suppression of Proinflammatory Mediators and Downregulation of the NF-?B Signaling Pathway. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27894402&form=6&db=m HSP90 inhibitor enhances anti-proliferative and apoptotic effects of celecoxib on HT-29 colorectal cancer cells via increasing BAX/BCL-2 ratio. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895584&form=6&db=m Induced Pluripotent Stem Cells Inhibit Bleomycin-Induced Pulmonary Fibrosis in Mice through Suppressing TGF-?1/Smad-Mediated Epithelial to Mesenchymal Transition. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895738&form=6&db=m Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27903840&form=6&db=m Evaluation of Antioxidant Intakes in Relation to Inflammatory Markers Expression Within the Normal Breast Tissue of Breast Cancer Patients. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27904529&form=6&db=m Anti-aggregatory effect of boswellic acid in high-fat fed rats: involvement of redox and inflammatory cascades. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27907187&form=6&db=m Substance P Induces HO-1 Expression in RAW 264.7 Cells Promoting Switch towards M2-Like Macrophages. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27920817&form=6&db=m Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27933547&form=6&db=m Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-?B and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27941877&form=6&db=m Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27991692&form=6&db=m Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27991924&form=6&db=m Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27992456&form=6&db=m Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27998175&form=6&db=m Ureteral Access Sheath Influence on the Ureteral Wall Evaluated by Cyclooxygenase-2 and Tumor Necrosis Factor-? in a Porcine Model. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27998871&form=6&db=m [Expressions of cyclooxygenase-2 and basic fibroblast growth factor in nasopharyngeal carcinoma and their association with radiotherapy sensitivity]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27999206&form=6&db=m Clinicopathological and prognostic significance of COX-2 immunohistochemical expression in breast cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28002200&form=6&db=m Association between expression of inflammatory markers in normal breast tissue and mammographic density among premenopausal and postmenopausal women. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28005072&form=6&db=m Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28017830&form=6&db=m Dermal Fibroblasts Promote Alternative Macrophage Activation Improving Impaired Wound Healing. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28028757&form=6&db=m Dimethyl Sulfoxide Attenuates Acute Lung Injury Induced by Hemorrhagic Shock/Resuscitation in Rats. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28029610&form=6&db=m Impact of local injection of brain-derived neurotrophic factor-expressing mesenchymal stromal cells (MSCs) combined with intravenous MSC delivery in a canine model of chronic spinal cord injury. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28029661&form=6&db=m Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28035965&form=6&db=m Anti-Neuroinflammatory ent-Kaurane Diterpenoids from Pteris multifida Roots. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28050122&form=6&db=m Chondrocyte-derived extracellular matrix suppresses pathogenesis of human pterygium epithelial cells by blocking the NF-?B signaling pathways. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053596&form=6&db=m Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053982&form=6&db=m A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28054666&form=6&db=m Cyclooxygenase-2 regulates TGF?-induced cancer stemness in triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28054961&form=6&db=m The In Vitro and In Vivo Anti-Inflammatory Effects of a Phthalimide PPAR-? Agonist. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056899&form=6&db=m PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28059042&form=6&db=m Alkaloids as Cyclooxygenase Inhibitors in Anticancer Drug Discovery. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28076474&form=6&db=m GROWTH FACTORS AND COX2 IN WOUND HEALING: AN EXPERIMENTAL STUDY WITH EHRLICH TUMORS. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28083817&form=6&db=m Carnosic Acid Induces Anti-Inflammatory Effects in Paraquat-Treated SH-SY5Y Cells Through a Mechanism Involving a Crosstalk Between the Nrf2/HO-1 Axis and NF-?B. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28092065&form=6&db=m Impact of celecoxib on inflammation during cancer surgery: a randomized clinical trial. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28094550&form=6&db=m Pharmacophore modelling, atom-based 3D-QSAR generation and virtual screening of molecules projected for mPGES-1 inhibitory activity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28095731&form=6&db=m N-Palmitoylethanolamine-oxazoline (PEA-OXA) as a new therapeutic strategy to control neuroinflammation: neuroprotective effects in experimental models of spinal cord and brain injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28096683&form=6&db=m Clinicopathological and immunohistochemical features of lung invasive mucinous adenocarcinoma based on computed tomography findings. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28101184&form=6&db=m Anti-inflammatory effects of luteolin on experimental autoimmune thyroiditis in mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28102676&form=6&db=m Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28114318&form=6&db=m Growth-Inhibiting Activity of Resveratrol Imine Analogs on Tumor Cells In Vitro. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28122556&form=6&db=m Therapeutic effects of Qian-Yu decoction and its three extracts on carrageenan-induced chronic prostatitis/chronic pelvic pain syndrome in rats. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123497&form=6&db=m Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123555&form=6&db=m Pathological significance and prognostic implications of heme oxygenase 1 expression in non-muscle-invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28127603&form=6&db=m Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28141864&form=6&db=m Green Tea Polyphenol Induces Changes in Cancer-Related Factors in an Animal Model of Bladder Cancer. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28150108&form=6&db=m Cyclooxygenase in Cancer Prevention and Treatments for Actinic Keratosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28152501&form=6&db=m Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28157665&form=6&db=m Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28159662&form=6&db=m Anti-inflammatory effect of geranium nanoemulsion macrophages induced with soluble protein of Candida albicans. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28161224&form=6&db=m COX-2 inhibitor prevents tumor induced down regulation of classical DC lineage specific transcription factor Zbtb46 resulting in immunocompetent DC and decreased tumor burden. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28161427&form=6&db=m Purification and function of two analgesic and anti-inflammatory peptides from coelomic fluid of the earthworm, Eisenia foetida. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28163951&form=6&db=m A Review on the Relationship between Aspirin and Bone Health. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28169543&form=6&db=m Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28174688&form=6&db=m Protection by Huang-Lian-Jie-Du decoction and its constituent herbs of lipopolysaccharide-induced acute kidney injury. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28178617&form=6&db=m Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28178650&form=6&db=m SerpinB3 upregulates the Cyclooxygenase-2 / ?-Catenin positive loop in colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28179185&form=6&db=m The use of diclofenac sodium in urological practice: A structural and neurochemical based review. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28189744&form=6&db=m Krüppel-like factor 4 regulates amyloid-? (A?)-induced neuroinflammation in Alzheimer's disease. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28192731&form=6&db=m Isotrifoliol inhibits pro-inflammatory mediators by suppression of TLR/NF-?B and TLR/MAPK signaling in LPS-induced RAW264.7 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212885&form=6&db=m Epinephrine promotes COX-2-dependent immune suppression in myeloid cells and cancer tissues. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28216638&form=6&db=m Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28219698&form=6&db=m Protective effects of diallyl disulfide against acetaminophen-induced nephrotoxicity: A possible role of CYP2E1 and NF-?B. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28228357&form=6&db=m Activation of mTOR/I?B-?/NF-?B pathway contributes to LPS-induced hypotension and inflammation in rats. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28231855&form=6&db=m COX-2 expression positively correlates with PD-L1 expression in human melanoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28232747&form=6&db=m In situ click chemistry generation of cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28236430&form=6&db=m Hand Ground Nanoscale Zn(II)-Coordination Polymers Derived from NSAIDs: Cell Migration Inhibition of Human Breast Cancer Cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28240006&form=6&db=m Effects of Six Weeks Endurance Training and Aloe Vera Supplementation on COX-2 and VEGF Levels in Mice with Breast Cancer causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28243356&form=6&db=m Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28245546&form=6&db=m Luteolin Inhibits Fibrillary ?-Amyloid1-40-Induced Inflammation in a Human Blood-Brain Barrier Model by Suppressing the p38 MAPK-Mediated NF-?B Signaling Pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28249225&form=6&db=m Cadmium-induced endoplasmic reticulum stress in chicken neutrophils is alleviated by selenium. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28254151&form=6&db=m Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28255114&form=6&db=m [MiR-26b inhibits proliferation, invasion, and migration of glioma by targeting cyclooxygenase-2]. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28256950&form=6&db=m Chronic depletion of gonadal testosterone leads to blood-brain barrier dysfunction and inflammation in male mice. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28260506&form=6&db=m pH-Dependent Behavior of Novel Gellan Beads Loaded with Naproxen. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272681&form=6&db=m Correlation of COX- 2 Expression in Colorectal Carcinoma with Clinicopathological Features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28272703&form=6&db=m The study of endogenous hepatocyte growth factor in the pathogenesis of intracranial aneurysms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28275297&form=6&db=m Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28277128&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2, syndecan-1 and connective tissue growth factor in benign and malignant breast tissue from premenopausal women. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28283079&form=6&db=m Molecular investigation of the direct anti-tumour effects of nonsteroidal anti-inflammatory drugs in a panel of canine cancer cell lines. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28283800&form=6&db=m Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28286042&form=6&db=m The therapeutic effects of Periploca forrestii Schltr. Stem extracts on collagen-induced arthritis by inhibiting the activation of Src/NF-?B signaling pathway in rats. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28300223&form=6&db=m Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28306608&form=6&db=m Evaluation of human glioma using in-vivo proton magnetic resonance spectroscopy combined with expression of cyclooxygenase-2: a preliminary clinical trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28314140&form=6&db=m An investigation of the immunotoxicity of oil sands processed water and leachates in trout leukocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28320516&form=6&db=m L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-?B inhibition and Nrf2 pathway activation. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28326700&form=6&db=m [In vitro investigation on the mechanism of cyclooxygenase-2 upregulation induced by spleen tyrosine kinase-nuclear factor ?B signaling in cancer pain caused by oral cancer-associated macrophage]. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28330776&form=6&db=m Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-?B signaling pathway in keratinocytes and mice skin. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28342204&form=6&db=m The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest and inhibits prostaglandin E2 induced proliferation in oral squamous carcinoma Tca8113 cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28345551&form=6&db=m Biliverdin Protects the Isolated Rat Lungs from Ischemia-reperfusion Injury via Antioxidative, Anti-inflammatory and Anti-apoptotic Effects. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28352075&form=6&db=m Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic Cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28356130&form=6&db=m Parecoxib reduced ventilation induced lung injury in acute respiratory distress syndrome. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28361247&form=6&db=m The potential curative effect of rebamipide in hepatic ischemia/reperfusion injury. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28370296&form=6&db=m Validation of a Multiplexed Gene Signature Assay for Diagnosis of Canine Cancers from Formalin-Fixed Paraffin-Embedded Tissues. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28376501&form=6&db=m Inducible GBP5 Mediates the Antiviral Response via Interferon-Related Pathways during Influenza A Virus Infection. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386336&form=6&db=m Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386381&form=6&db=m Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28386897&form=6&db=m Alleviative effect of selenium on inflammatory damage caused by lead via inhibiting inflammatory factors and heat shock proteins in chicken testes. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28397014&form=6&db=m Geraniol attenuates 4NQO-induced tongue carcinogenesis through downregulating the activation of NF-?B in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28398606&form=6&db=m Variation in Essential Oil and Bioactive Compounds of Curcuma kwangsiensis Collected from Natural Habitats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400769&form=6&db=m Role of Modulator of Inflammation Cyclooxygenase-2 in Gammaherpesvirus Mediated Tumorigenesis. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28402256&form=6&db=m A potential anti-tumor effect of leukotriene C4 through the induction of 15-hydroxyprostaglandin dehydrogenase expression in colon cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28405852&form=6&db=m Chlorinated Flavonoids Modulate the Inflammatory Process in Human Blood. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28407689&form=6&db=m Radioiodinated indomethacin amide for molecular imaging of cyclooxygenase-2 expressing tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28408819&form=6&db=m Simvastatin nanoparticles attenuated intestinal ischemia/reperfusion injury by downregulating BMP4/COX-2 pathway in rats. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28410935&form=6&db=m Erratum to "Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells" [Redox Biol. 11 (2017) 653-662]. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28413655&form=6&db=m Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28418604&form=6&db=m Loss of INK4a/Arf gene enhances ultraviolet radiation-induced cutaneous tumor development. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28419378&form=6&db=m Arsenic-induced testicular toxicity in Gallus gallus: Expressions of inflammatory cytokines and heat shock proteins. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28421541&form=6&db=m Systemic Inflammation as a Driver of Brain Injury: the Astrocyte as an Emerging Player. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28422079&form=6&db=m Synthetic Fluororutaecarpine Inhibits Inflammatory Stimuli and Activates Endothelial Transient Receptor Potential Vanilloid-Type 1. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28425860&form=6&db=m A Novel Recombinant Multi-Epitope Vaccine Could Induce Specific Cytotoxic T Lymphocyte Response In Vitro and In Vivo. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28430638&form=6&db=m Adjuvant celecoxib and lanreotide following transarterial chemoembolisation for unresectable hepatocellular carcinoma: a randomized pilot study. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28442526&form=6&db=m Morphoproteomic-Guided Treatment of Chemotherapy Resistant Colon Cancer using Natural Based Therapies: A Case Study. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28443766&form=6&db=m Pioglitazone, a Specific Ligand of the Peroxisome Proliferator-Activated Receptor Gamma Reduces Gastric Mucosal Injury Induced by Ischaemia/Reperfusion in Rat. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28444165&form=6&db=m Proinflammatory mediators related to orthodontically induced periapical root resorption in rat mandibular molars. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28444871&form=6&db=m Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways and inflammatory mediators. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28448072&form=6&db=m Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449470&form=6&db=m Impact of cyclooxygenase-2 and prostaglandin-E2 expression on clinical outcome after pulmonary metastasectomy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454432&form=6&db=m Prognostic and predictive role of COX-2, XRCC1 and RASSF1 expression in patients with esophageal squamous cell carcinoma receiving radiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28458638&form=6&db=m Oriental Medicine Samhwangsasim-tang Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Th1 Cell Responses and Upregulating Treg Cell Responses. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28467233&form=6&db=m Moringa oleifera from Cambodia Ameliorates Oxidative Stress, Hyperglycemia, and Kidney Dysfunction in Type 2 Diabetic Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28467670&form=6&db=m High COX-2 expression in canine mast cell tumours is associated with proliferation, angiogenesis and decreased overall survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28469528&form=6&db=m The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474124&form=6&db=m Expressions and clinical significance of COX-2, VEGF-C, and EFGR in endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28479391&form=6&db=m Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28484748&form=6&db=m Tangeretin Improves Glucose Uptake in a Coculture of Hypertrophic Adipocytes and Macrophages by Attenuating Inflammatory Changes. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28486173&form=6&db=m Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: modulation by the lipogenic phenotype of colon tumors. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489236&form=6&db=m Histologic correlation of VEGF and COX-2 expression with tumor size in squamous cell carcinoma of the larynx and hypopharynx. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489511&form=6&db=m Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28501692&form=6&db=m Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28503046&form=6&db=m Reflections about Osteoarthritis and Curcuma longa. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28504179&form=6&db=m Immunomodulatory effects of xanthan gum in LPS-stimulated RAW 264.7 macrophages. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28510033&form=6&db=m The Antagonistic Effect of Selenium on Cadmium-Induced Damage and mRNA Levels of Selenoprotein Genes and Inflammatory Factors in Chicken Kidney Tissue. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521457&form=6&db=m Expression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521485&form=6&db=m Combination of celecoxib and PD184161 exerts synergistic inhibitory effects on gallbladder cancer cell proliferation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28534978&form=6&db=m Demethylzeylasteral ameliorates inflammation in a rat model of unilateral ureteral obstruction through inhibiting activation of the NF??B pathway. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28537433&form=6&db=m Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539710&form=6&db=m Anti-inflammatory Effects of KOTMIN13: A Mixed Herbal Medicine in LPS-stimulated RAW 264.7 Cells and Mouse Edema Models. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28548071&form=6&db=m The Pathogenetic Role of the HGF/c-Met System in Papillary Carcinoma of the Thyroid. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28556814&form=6&db=m Combined Treatment with Hyaluronic Acid and Mesalamine Protects Rats from Inflammatory Bowel Disease Induced by Intracolonic Administration of Trinitrobenzenesulfonic Acid. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28559977&form=6&db=m Oxysophocarpine reduces oxygen-glucose deprivation-induced microglial activation and injury. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28560423&form=6&db=m Prokaryotic expression, purification and characterization of human cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28561817&form=6&db=m Epigallocatechin-3-gallate attenuates cerebral cortex damage and promotes brain regeneration in acrylamide-treated rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28567040&form=6&db=m A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28573063&form=6&db=m Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583427&form=6&db=m Cyclooxygenase-2 inhibitors differentially attenuate pentylenetetrazol-induced seizures and increase of pro- and anti-inflammatory cytokine levels in the cerebral cortex and hippocampus of mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583816&form=6&db=m Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28587858&form=6&db=m Rebamipide reduces amyloid-? 1-42 (A?42) production and ameliorates A?43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28591725&form=6&db=m FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28594379&form=6&db=m Anti-Inflammatory Activities and Liver Protection of Alisol F and 25-Anhydroalisol F through the Inhibition of MAPK, STAT3, and NF-?B Activation In Vitro and In Vivo. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28598563&form=6&db=m Alpha lipoic acid prevents doxorubicin-induced nephrotoxicity by mitigation of oxidative stress, inflammation, and apoptosis in rats. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599442&form=6&db=m Promoter methylation status of the tumor suppressor genes p16 and cadherin 1 in cervical intraepithelial neoplasia. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28601236&form=6&db=m Role of cyclooxygenase-2 inhibitors in the survival outcome of colorectal cancer patients: A population-based cohort study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28604419&form=6&db=m Prognostic significance of cyclooxygenase 2 and phosphorylated Akt1 overexpression in primary nonmetastatic and metastatic cutaneous melanomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28614972&form=6&db=m Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28624843&form=6&db=m Expressions of Ras Homolog Gene Family, Member A (RhoA) and Cyclooxygenase-2 (COX-2) Proteins in Early Gastric Cancer and Their Role in the Development of Gastric Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28625237&form=6&db=m [Study on mechanisms and myocardial protective effect of Qishen Yiqi dropping pills on rats with myocardial infarction]. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28633143&form=6&db=m Tumor-Associated Macrophages in the Development of 4-Nitroquinoline-1-Oxide-Induced Tongue Squamous Cell Carcinoma in a Mouse Model. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28637971&form=6&db=m Esculentoside A ameliorates cecal ligation and puncture-induced acute kidney injury in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28642128&form=6&db=m Immunomodulation of Parkinson's disease using Mucuna pruriens (Mp). unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28651306&form=6&db=m Heme Oxygenase-1 Induction and Anti-inflammatory Actions of Atractylodes macrocephala and Taraxacum herba Extracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28652251&form=6&db=m Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659027&form=6&db=m Eclipta prostrata Improves DSS-Induced Colitis through Regulation of Inflammatory Response in Intestinal Epithelial Cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659029&form=6&db=m The Mixture of Anemarrhena asphodeloides and Coptis chinensis Attenuates High-Fat Diet-Induced Colitis in Mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28659803&form=6&db=m Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28664403&form=6&db=m RAGE-Specific Inhibitor FPS-ZM1 Attenuates AGEs-Induced Neuroinflammation and Oxidative Stress in Rat Primary Microglia. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28666860&form=6&db=m Novel 4-acetamide-2-alkylthio-N-acetanilides resembling nimesulide: Synthesis, cell viability evaluation and in silico studies. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28670247&form=6&db=m Differential expression of tumor necrosis factor ?, interleukin 1?, nuclear factor ?B in nasal mucosa among chronic rhinosinusitis patients with and without polyps. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28671636&form=6&db=m Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-?B/TNF-? Signaling. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28685867&form=6&db=m MiR-150 alleviates neuropathic pain via inhibiting toll-like receptor 5. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28692590&form=6&db=m Vestibular Schwannoma Growth With Aspirin and Other Nonsteroidal Anti-inflammatory Drugs. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28693228&form=6&db=m Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28698513&form=6&db=m Anti-Inflammatory Activity of Citric Acid-Treated Wheat Germ Extract in Lipopolysaccharide-Stimulated Macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28703832&form=6&db=m Protective vascular effects of quercitrin in acute TNBS-colitis in rats: the role of nitric oxide. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28720504&form=6&db=m Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28724634&form=6&db=m Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28726269&form=6&db=m Previous physical exercise alters the hepatic profile of oxidative-inflammatory status and limits the secondary brain damage induced by severe traumatic brain injury in rats. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28728977&form=6&db=m Synthesis and characterization of boron fenbufen and its F-18 labeled homolog for boron neutron capture therapy of COX-2 overexpressed cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,1,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28729694&form=6&db=m Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the Apc (Min/+) mouse model of intestinal tumorigenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28732079&form=6&db=m LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28733349&form=6&db=m Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28750089&form=6&db=m A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28751820&form=6&db=m Cynanchum wilfordii Polysaccharides Suppress Dextran Sulfate Sodium-Induced Acute Colitis in Mice and the Production of Inflammatory Mediators from Macrophages. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28753918&form=6&db=m The Anti-Inflammatory Properties of Citrus wilsonii Tanaka Extract in LPS-Induced RAW 264.7 and Primary Mouse Bone Marrow-Derived Dendritic Cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759702&form=6&db=m Protective effect of proanthocyanidins against doxorubicin-induced nephrotoxicity in rats. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28759712&form=6&db=m Mechanisms of action of nonpeptide hormones on resveratrol-induced antiproliferation of cancer cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765120&form=6&db=m Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765772&form=6&db=m Anti-inflammatory effects of Nelumbo leaf extracts and identification of their metabolites. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28769030&form=6&db=m miR-30a acts as a tumor suppressor by double-targeting COX-2 and BCL9 in H. pylori gastric cancer models. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28781793&form=6&db=m Activation of the arachidonic acid metabolic pathway and induction of sleep disturbance by sacral osteoblastoma: A case report. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28782620&form=6&db=m Anti-inflammatory effect of Cortex Eucommiae via modulation of the toll-like receptor 4 pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28785285&form=6&db=m Crosstalk with Inflammatory Macrophages Shapes the Regulatory Properties of Multipotent Adult Progenitor Cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28786533&form=6&db=m MiR-216a-3p inhibits colorectal cancer cell proliferation through direct targeting COX-2 and ALOX5. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28789345&form=6&db=m Expression and clinical significance of cyclooxygenase 2 and survivin in human gliomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28795275&form=6&db=m Effects of photobiomodulation therapy and topical non-steroidal anti-inflammatory drug on skeletal muscle injury induced by contusion in rats-part 2: biochemical aspects. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28804691&form=6&db=m Combination of celecoxib (Celebrex(®)) and CD19 CAR-redirected CTL immunotherapy for the treatment of B-cell non-Hodgkin's lymphomas. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28806973&form=6&db=m Protective effects of orange (Citrus sinensis L.) peel aqueous extract and hesperidin on oxidative stress and peptic ulcer induced by alcohol in rat. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28807001&form=6&db=m The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808213&form=6&db=m The interaction between the Wnt/?-catenin signaling cascade and PKG activation in cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808377&form=6&db=m Anti-inflammatory Potential of Petiveria alliacea on Activated RAW264.7 Murine Macrophages. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808397&form=6&db=m Genistein-attenuated Gastric Injury on Indomethacin-induced Gastropathy in Rats. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28808873&form=6&db=m Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28809447&form=6&db=m Pulmonary delivery of tea tree oil-?-cyclodextrin inclusion complexes for the treatment of fungal and bacterial pneumonia. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28819122&form=6&db=m Anti-inflammatory drugs suppress ultrasound-mediated mesenchymal stromal cell tropism to kidneys. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28821452&form=6&db=m Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28822019&form=6&db=m Gypenoside IX Suppresses p38 MAPK/Akt/NF?B Signaling Pathway Activation and Inflammatory Responses in Astrocytes Stimulated by Proinflammatory Mediators. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28823533&form=6&db=m Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28825114&form=6&db=m Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 ameliorate neuroinflammatory responses in chronic cerebral hypoperfusion model by blocking NF-?B pathways. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28828990&form=6&db=m Update on COX-2 selective inhibitors: chemical classification, side effects and their use in cancers and neuronal diseases. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28830212&form=6&db=m Heat-Processed Scutellariae Radix Protects Hepatic Inflammation through the Amelioration of Oxidative Stress in Lipopolysaccharide-Induced Mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28837884&form=6&db=m Macrophages induce EMT to promote invasion of lung cancer cells through the IL-6-mediated COX-2/PGE2/?-catenin signalling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28839360&form=6&db=m Prim-O-glucosylcimifugin Attenuates Lipopolysaccharideinduced Inflammatory Response in RAW 264.7 Macrophages. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28840833&form=6&db=m The anti-inflammatory and anti-glycative effects of rosmarinic acid in the livers of type 1 diabetic mice. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28843178&form=6&db=m Esculentoside A exerts anti-inflammatory activity in microglial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28844858&form=6&db=m miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-?B/COX-2 activation. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28847144&form=6&db=m Association of Activation of Induced COX-2, iNOS and Cytokines with NF-kappa B Depression by Taiwan Wild Grape Ethanolic Extract in Mice. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849084&form=6&db=m Effects of Tribulus terrestris on monosodium iodoacetate?induced osteoarthritis pain in rats. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28855534&form=6&db=m Celecoxib normalizes the tumor microenvironment and enhances small nanotherapeutics delivery to A549 tumors in nude mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28856682&form=6&db=m Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses' health study and health professionals follow-up study. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28871473&form=6&db=m Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28873611&form=6&db=m A galactomannoglucan derived from Agaricus brasiliensis: Purification, characterization and macrophage activation via MAPK and I?B/NF?B pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28874135&form=6&db=m Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28875496&form=6&db=m G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28888039&form=6&db=m Role of ALDH1 in the prognosis of esophageal cancer and its relationship with tumor microenvironment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28905500&form=6&db=m Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28914791&form=6&db=m Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-?B and HO-1/Nrf2 Pathways. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28919220&form=6&db=m Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro-inflammatory mediators. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28927045&form=6&db=m Correlation analysis between expression of PCNA, Ki-67 and COX-2 and X-ray features in mammography in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28930532&form=6&db=m Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28932846&form=6&db=m A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28933476&form=6&db=m Piceatannol inhibits the IL-1?-induced inflammatory response in human osteoarthritic chondrocytes and ameliorates osteoarthritis in mice by activating Nrf2. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28935965&form=6&db=m Aromatic side-chain conformational switch on the surface of the RNA Recognition Motif enables RNA discrimination. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28942652&form=6&db=m Polyphenols from blossoms of Citrus aurantium L. var. amara Engl. show significant anti-complement and anti-inflammatory effects. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28946145&form=6&db=m Impact of Cyclooxygenase-2 1195 G-Carrier Genotype Associated with Intestinal Metaplasia and Endoscopic Findings Based on Kyoto Classification. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28948694&form=6&db=m Pomegranate By-Products in Colorectal Cancer Chemoprevention: Effects in Apc-Mutated Pirc Rats and Mechanistic Studies In Vitro and Ex Vivo. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28949404&form=6&db=m The role of Syk/I?B-?/NF-?B pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28954384&form=6&db=m Ethyl acetate fraction of Terminalia bellirica (Gaertn.) Roxb. fruits inhibits proinflammatory mediators via down regulating nuclear factor-?B in LPS stimulated Raw 264.7 cells. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28956485&form=6&db=m Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28956695&form=6&db=m Tumor Cell Invasion Induced by Radiation in Balb/C Mouse is Prevented by the Cox-2 Inhibitor NS-398. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28971779&form=6&db=m New ferrocene compounds as selective cyclooxygenase (COX-2) inhibitors: design, synthesis, cytotoxicity and enzyme-inhibitory activity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28977690&form=6&db=m Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28978083&form=6&db=m EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28987361&form=6&db=m Comparative effect of horse gram and black gram on inflammatory mediators and antioxidant status. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29024717&form=6&db=m Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-?B signaling pathways. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29025423&form=6&db=m Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29026721&form=6&db=m Expression of the genes for peroxisome proliferator-activated receptor-?, cyclooxygenase-2, and proinflammatory cytokines in granulosa cells from women with polycystic ovary syndrome. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29028945&form=6&db=m Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29037225&form=6&db=m YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29037857&form=6&db=m Exploring the Role of IL-32 in HIV-Related Kaposi Sarcoma. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29040306&form=6&db=m Micheliolide suppresses LPS-induced neuroinflammatory responses. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29042248&form=6&db=m The antidepressant- and anxiolytic-like effects of fluoxetine and clozapine in chronically isolated rats involve inhibition of hippocampal TNF-?. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29049411&form=6&db=m XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29069290&form=6&db=m Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29080687&form=6&db=m A comparative study: Difference in omega-6/omega-3 balance and saturated fat in diets for Atlantic salmon (Salmo salar) affect immune-, fat metabolism-, oxidative and apoptotic-gene expression, and eicosanoid secretion in head kidney leukocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29081218&form=6&db=m Effects of Aspirin, Nonsteroidal Anti-inflammatory Drugs, Statin and COX2 Inhibitor on the Developments of Urological Malignancies: A Population-Based Study with 10-Year Follow-up Data in Korea. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29081696&form=6&db=m Implication of Gastric Cancer Molecular Genetic Markers in Surgical Practice. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29102164&form=6&db=m Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29104078&form=6&db=m Eucalyptus robusta leaves methanolic extract suppresses inflammatory mediators by specifically targeting TLR4/TLR9, MPO, COX2, iNOS and inflammatory cytokines in experimentally-induced endometritis in rats. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29107071&form=6&db=m Role of TLR4 in olfactory-based spatial learning activity of neonatal mice after developmental exposure to diesel exhaust origin secondary organic aerosol. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29107204&form=6&db=m Laser photobiomodulation of pro-inflammatory mediators on Walker Tumor 256 induced rats. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29109117&form=6&db=m Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29113232&form=6&db=m Inhibition of cyclooxygenase-2 sensitizes lung cancer cells to radiation-induced apoptosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29131381&form=6&db=m Long non-coding RNA cox-2 prevents immune evasion and metastasis of hepatocellular carcinoma by altering M1/M2 macrophage polarization. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29136779&form=6&db=m Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson's disease and cell culture via inactivating TLR4/NF-?B pathway. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29137258&form=6&db=m Aberrantly activated Cox-2 and Wnt signaling interact to maintain cancer stem cells in glioblastoma. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29140138&form=6&db=m COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29140156&form=6&db=m Conditioned medium from human gingival mesenchymal stem cells protects motor-neuron-like NSC-34 cells against scratch-injury-induced cell death. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29147175&form=6&db=m Expression of Cyclooxygenase-1 and 2 in Epithelial Ovarian Cancer: A Clinicopathologic Study. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29147402&form=6&db=m Immunohistochemical Analysis of Cyclooxygenase-2 in Non-Melanocytic Skin Cancer: Correlation With Morphological Subtype and Histologic Grade. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29149667&form=6&db=m Tumor Acidosis and Hypoxia Differently Modulate the Inflammatory Program: Measurements In Vitro and In Vivo. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152086&form=6&db=m COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29156646&form=6&db=m Inhibition of bcl-2 and cox-2 Protein Expression after Local Application of a New Carmustine-Loaded Clinoptilolite-Based Delivery System in a Chemically Induced Skin Cancer Model in Mice. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29159716&form=6&db=m Rotula aquatica Lour attenuates secretion of proinflammatory mediators and cytokines in lipopolysaccharide-induced inflammatory responses in murine RAW 264.7 macrophages. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29167166&form=6&db=m Blood-borne interleukin-1? acts on the subfornical organ to upregulate the sympathoexcitatory milieu of the hypothalamic paraventricular nucleus. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29181068&form=6&db=m Immunohistochemical features and staging of early gastric cancer. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29183759&form=6&db=m Phosphodiesterase 4B plays a role in benzophenone-3-induced phototoxicity in normal human keratinocytes. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29183796&form=6&db=m Heat shock protein 70 suppresses neuroinflammation induced by ?-synuclein in astrocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29185355&form=6&db=m The Effect of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Rat's Subglottic Stenosis Model. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187079&form=6&db=m Anti-inflammatory, antioxidant and anti-apoptotic activity of diosmin in acetic acid-induced ulcerative colitis. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29197120&form=6&db=m Resveratrol inhibits obesity-associated adipose tissue dysfunction and tumor growth in a mouse model of postmenopausal claudin-low breast cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29199874&form=6&db=m Necrostatin-1 attenuates lipopolysaccharide-induced acute lung injury in mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29200096&form=6&db=m TGF-?1 protection against A?1-42-induced hippocampal neuronal inflammation and apoptosis by T?R-I. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29200735&form=6&db=m Therapeutic Effects of diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29201696&form=6&db=m Expressions of TIMP-1, COX-2 and MMP-7 in Colon Polyp and Colon Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29202856&form=6&db=m Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29207498&form=6&db=m Steppogenin Isolated from Cudrania tricuspidata Shows Antineuroinflammatory Effects via NF-?B and MAPK Pathways in LPS-Stimulated BV2 and Primary Rat Microglial Cells. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29211250&form=6&db=m Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3'-untranslated region. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29230689&form=6&db=m The combination of curcumin and 5-fluorouracil in cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29235601&form=6&db=m Ruthenium(ii) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29235761&form=6&db=m The effect of perioperative analgesic drugs omnopon and dexketoprofen on the functional activity of immune cells in murine model of tumor surgery. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29238224&form=6&db=m Prognostic value of Cox-2 and PD-L1 expression and its relationship with tumor-infiltrating lymphocytes in resected lung adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29239335&form=6&db=m Saponins from causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29242151&form=6&db=m Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29247327&form=6&db=m IL-21 Enhances the Degradation of Cartilage Through the JAK-STAT Signaling Pathway During Osteonecrosis of Femoral Head Cartilage. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254791&form=6&db=m Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29256845&form=6&db=m Anti-Inflammatory Activity and Bioactive Constituents of Cultivated Fruiting Bodies of Xylaria nigripes (Ascomycetes), a Chinese Medicinal Fungus. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29259464&form=6&db=m Expression of cytokine-induced neutrophil chemoattractant suppresses tumor necrosis factor alpha expression and thereby prevents the follicles from undergoing atresia and apoptosis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29262273&form=6&db=m Dietary supplementation with Allium hirtifolium and/or Astragalus hamosus improved ?memory and reduced neuro-inflammation in the rat model of Alzheimer's disease. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29267220&form=6&db=m Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29278445&form=6&db=m The Effect of 7-Hydroxycoumarin on Dextran Sulfate Sodium-induced Ulcerative Colitis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29279587&form=6&db=m Cyclooxygenase-2 (COX2) expression in adenocarcinoma surpasses that of squamous cell carcinoma in the uterine cervix. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29280053&form=6&db=m CD200Fc Attenuates Retinal Glial Responses and RGCs Apoptosis After Optic Nerve Crush by Modulating CD200/CD200R1 Interaction. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29285052&form=6&db=m Suppression of Alzheimer's disease-related phenotypes by the heat shock protein 70 inducer, geranylgeranylacetone, in APP/PS1 transgenic mice via the ERK/p38 MAPK signaling pathway. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29285096&form=6&db=m Anti-inflammatory effect of delphinidin on intramedullary spinal pressure in a spinal cord injury rat model. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29289998&form=6&db=m Molecular signature of nitric oxide on major cancer hallmarks of colorectal carcinoma. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29295852&form=6&db=m Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPAR?/?-Dependent Vasodilator Pathway. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29297092&form=6&db=m Conjunctival melanoma: association of cyclooxygenase-2 tumor expression to prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29315967&form=6&db=m Curcumin ameliorates doxorubicin-induced cardiotoxicity by abrogation of inflammation, apoptosis, oxidative DNA damage, and protein oxidation in rats. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29317586&form=6&db=m [Relationship between the gene polymorphisms of oxidative metabolism enzyme of exogenous chemicals and the susceptibility to neoplasms]. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29323698&form=6&db=m XIST accelerates neuropathic pain progression through regulation of miR-150 and ZEB1 in CCI rat models. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29324448&form=6&db=m The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29328882&form=6&db=m Effects of Salvia miltiorrhiza Polysaccharides on Lipopolysaccharide-Induced Inflammatory Factor Release in RAW264.7 Cells. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29329586&form=6&db=m IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-?B activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29334666&form=6&db=m Effects of Berberine chloride on the liver of streptozotocin-induced diabetes in albino Wistar rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29335811&form=6&db=m Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29340045&form=6&db=m RIP140 and LCoR expression in gastrointestinal cancers. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29341436&form=6&db=m A novel near-infrared fluorescent probe for monitoring cyclooxygenase-2 in inflammation and tumor. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29345893&form=6&db=m Fullerene C?? Derivatives Attenuated Microglia-Mediated Prion Peptide Neurotoxicity. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29352129&form=6&db=m Molecular characterization of the grape seeds extract's effect against chemically induced liver cancer: In vivo and in vitro analyses. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29361881&form=6&db=m Dimethyl fumarate attenuates neuroinflammation and neurobehavioral deficits induced by experimental traumatic brain injury. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29367089&form=6&db=m Cortisol inhibits NF-?B and MAPK pathways in LPS activated bovine endometrial epithelial cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29367765&form=6&db=m Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29373690&form=6&db=m Novel Function of Cyclooxygenase-2: Suppressing Mycobacteria by Promoting Autophagy via the Protein Kinase B/Mammalian Target of Rapamycin Pathway. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29373910&form=6&db=m Expression of VEGF and Cox-2 in Patients with Esophageal Squamous Cell Carcinoma diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29374956&form=6&db=m Antitumorigenic Effects of ZAK?, an Alternative Splicing Isoform of ZAK. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29377693&form=6&db=m Antibodies as Carrier Molecules: Encapsulating Anti-Inflammatory Drugs inside Herceptine. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29396430&form=6&db=m Functional loss of p53 cooperates with the in vivo microenvironment to promote malignant progression of gastric cancers. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399062&form=6&db=m The effect of hydroxy safflower yellow A on coronary heart disease through Bcl-2/Bax and PPAR-?. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399292&form=6&db=m Anti-neuroinflammatory effects of ethanolic extract of black chokeberry ( causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29404887&form=6&db=m MicroRNA-101 inhibits angiogenesis via COX-2 in endometrial carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29408308&form=6&db=m Inflammatory Gene Polymorphisms in Lung Cancer Susceptibility. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29410309&form=6&db=m Gastroprotective effects of Hwanglyeonhaedok-tang against Helicobacter pylori-induced gastric cell injury. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29420225&form=6&db=m Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29429524&form=6&db=m Nintedanib effects on delaying cancer progression and decreasing COX-2 and IL-17 in the prostate anterior lobe in TRAMP mice. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29429545&form=6&db=m The Presence of Cyclooxygenase 2, Tumor-Associated Macrophages, and Collagen Alignment as Prognostic Markers for Invasive Breast Carcinoma Patients. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29441888&form=6&db=m Anti-fibrotic potential of a causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29448097&form=6&db=m Selective degradation of BET proteins with dBET1, a proteolysis-targeting chimera, potently reduces pro-inflammatory responses in lipopolysaccharide-activated microglia. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29448206&form=6&db=m Regulation of JAK2/STAT3 and NF-?B signal transduction pathways; Veronica polita alleviates dextran sulfate sodium-induced murine colitis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29453046&form=6&db=m Molecular chemoprevention by morin - A plant flavonoid that targets nuclear factor kappa B in experimental colon cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29453346&form=6&db=m Anti-inflammatory effect of Tauroursodeoxycholic acid in RAW 264.7 macrophages, Bone marrow-derived macrophages, BV2 microglial cells, and spinal cord injury. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29456712&form=6&db=m MicroRNA-144 functions as a tumor suppressor in gastric cancer by targeting cyclooxygenase-2. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29460012&form=6&db=m ISSLS PRIZE IN BASIC SCIENCE 2018: Growth differentiation factor-6 attenuated pro-inflammatory molecular changes in the rabbit anular-puncture model and degenerated disc-induced pain generation in the rat xenograft radiculopathy model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29468988&form=6&db=m COX-2 in Radiotherapy; a potential target for radioprotection and radiosensitization. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29471006&form=6&db=m Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29475907&form=6&db=m Anti-inflammatory Activity of ?-Carotene, Lycopene and Tri- diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29481741&form=6&db=m Celecoxib-Induced Self-Assembly of Smart Albumin-Doxorubicin Conjugate for Enhanced Cancer Therapy. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29482584&form=6&db=m Differential cyclooxygenase expression levels and survival associations in type I and type II ovarian tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29484338&form=6&db=m Polydatin inhibits the IL-1?-induced inflammatory response in human osteoarthritic chondrocytes by activating the Nrf2 signaling pathway and ameliorates murine osteoarthritis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29484840&form=6&db=m NF-?B/p53-activated inflammatory response involves in diquat-induced mitochondrial dysfunction and apoptosis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29486731&form=6&db=m Combined activity of COX-1 and COX-2 is increased in non-neoplastic colonic mucosa from colorectal neoplasia patients. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29492204&form=6&db=m Stromal versus tumoral inflammation differentially contribute to metastasis and poor survival in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29492489&form=6&db=m Chlorinated cobalt alkyne complexes derived from acetylsalicylic acid as new specific antitumor agents. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29501042&form=6&db=m Clostridium difficile toxin B recombinant protein inhibits tumor growth and induces apoptosis through inhibiting Bcl-2 expression, triggering inflammatory responses and activating C-erbB-2 and Cox-2 expression in breast cancer mouse model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29505957&form=6&db=m COX-2 Forms Regulatory Loop with YAP to Promote Proliferation and Tumorigenesis of Hepatocellular Carcinoma Cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29518393&form=6&db=m Naringenin ameliorates learning and memory impairment following systemic lipopolysaccharide challenge in the rat. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29518899&form=6&db=m Halo-Substituted Chalcones and Azachalcones-Inhibited, Lipopolysaccharited-Stimulated, Pro-Inflammatory Responses through the TLR4-Mediated Pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29520973&form=6&db=m Fluorescence tumor imaging by i.v. administered indocyanine green in a mouse model of colitis-associated colon cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29532213&form=6&db=m Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29548914&form=6&db=m Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552755&form=6&db=m Prognostic significance of EGFR and COX-2 expression in colorectal cancer and their association. A study in Greek population. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29553845&form=6&db=m Nano-gold displayed anti-inflammatory property via NF-kB pathways by suppressing COX-2 activity. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29556059&form=6&db=m Molecular Insights into the Interaction of RONS and Thieno[3,2-c]pyran Analogs with SIRT6/COX-2: A Molecular Dynamics Study. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29559247&form=6&db=m COX-2 as a determinant of lower disease-free survival for patients affected by ameloblastoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29562216&form=6&db=m The effectiveness of cyclooxygenase-2 inhibitors and evaluation of angiogenesis in the model of experimental colorectal cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29564801&form=6&db=m Bioinformatics Based Therapeutic Effects of Sinomenium Acutum. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29564969&form=6&db=m The effect of rutin on ovarian ischemia-reperfusion injury in a rat model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29568008&form=6&db=m Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29568934&form=6&db=m Tanshinone?IIA attenuates the deleterious effects of oxidative stress in osteoporosis through the NF??B signaling pathway. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29578814&form=6&db=m Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29579222&form=6&db=m Inhibition of fatty acid amide hydrolase by PF-3845 alleviates the nitrergic and proinflammatory response in rat hippocampus following acute stress. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29587478&form=6&db=m Celecoxib Conjugated Fluorescent Probe for Identification and Discrimination of Cyclooxygenase-2 Enzyme in Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29587668&form=6&db=m Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29596308&form=6&db=m EP4 as a Therapeutic Target for Aggressive Human Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29609579&form=6&db=m Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29625260&form=6&db=m Protective effects of Polygonum multiflorum on ischemic stroke rat model analysed by 1H NMR metabolic profiling. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29629026&form=6&db=m Effect of vitamin C on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated early colon cancer in mice. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29630947&form=6&db=m Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-?B signaling pathway. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29631612&form=6&db=m Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29632944&form=6&db=m Dietary supplementation with omega-3 polyunsaturated fatty acid-rich oils protects against visible-light-induced retinal damage in vivo. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29642394&form=6&db=m Neuroprotective Effects of Platonin, a Therapeutic Immunomodulating Medicine, on Traumatic Brain Injury in Mice after Controlled Cortical Impact. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29643988&form=6&db=m Combination therapy of chitosan, gynostemma, and motherwort alleviates the progression of experimental rat chronic renal failure by inhibiting STAT1 activation. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29660467&form=6&db=m Investigation of constituents from Cinnamomum camphora (L.) J. Presl and evaluation of their anti-inflammatory properties in lipopolysaccharide-stimulated RAW 264.7 macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29661238&form=6&db=m EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663159&form=6&db=m Evaluation of the effect of polyphenol of escin compared with ibuprofen and dexamethasone in synoviocyte model for osteoarthritis: an in vitro study. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29677563&form=6&db=m Polysaccharide of Hericium erinaceus attenuates colitis in C57BL/6 mice via regulation of oxidative stress, inflammation-related signaling pathways and modulating the composition of the gut microbiota. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29679652&form=6&db=m Effects of phenidone (DuCLOX-2/5 inhibitor) against N-methyl-N-nitrosourea induced mammary gland carcinoma in albino rats. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29679858&form=6&db=m Anti-inflammatory effect of Apo-9'-fucoxanthinone via inhibition of MAPKs and NF-kB signaling pathway in LPS-stimulated RAW 264.7 macrophages and zebrafish model. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29681851&form=6&db=m DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29684860&form=6&db=m Polyphenol-rich extract of Ocimum gratissimum leaves ameliorates colitis via attenuating colonic mucosa injury and regulating pro-inflammatory cytokines production and oxidative stress. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29687202&form=6&db=m Attenuation of Aluminum Chloride-Induced Neuroinflammation and Caspase Activation Through the AKT/GSK-3? Pathway by Hesperidin in Wistar Rats. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29691532&form=6&db=m Black rice anthocyanin-rich extract and rosmarinic acid, alone and in combination, protect against DSS-induced colitis in mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29693723&form=6&db=m Aqueous and Ethanol Extracts of Daylily Flower (Hemerocallis fulva L.) Protect HUVE Cells Against High Glucose. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29694352&form=6&db=m Effects of loxoprofen on the apical root resorption during orthodontic tooth movement in rats. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29700423&form=6&db=m Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29713361&form=6&db=m Effects of Angelica gigas Nakai as an Anti-Inflammatory Agent in In Vitro and In Vivo Atopic Dermatitis Models. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29714143&form=6&db=m Cutaneous Application of Celecoxib for Inflammatory and Cancer Diseases. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29715103&form=6&db=m Bidirectional Regulation of COX-2 Expression Between Cancer Cells and Macrophages. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29725269&form=6&db=m Extraction Process, Component Analysis, and In Vitro Antioxidant, Antibacterial, and Anti-Inflammatory Activities of Total Flavonoid Extracts from Abutilon theophrasti Medic. Leaves. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29725354&form=6&db=m Src Is a Prime Target Inhibited by Celtis choseniana Methanol Extract in Its Anti-Inflammatory Action. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29725387&form=6&db=m PF-2341066 combined with celecoxib promotes apoptosis and inhibits proliferation in human cholangiocarcinoma QBC939 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29726034&form=6&db=m Flavonoids from Boldoa purpurascens inhibit proinflammatory cytokines (TNF-? and IL-6) and the expression of COX-2. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29726862&form=6&db=m Natural and synthetic avenanthramides activate caspases 2, 8, 3 and downregulate hTERT, MDR1 and COX-2 genes in CaCo-2 and Hep3B cancer cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29727350&form=6&db=m Cyclooxygenase Inhibitors in Epithelial Ovarian Cancer Treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29736620&form=6&db=m Cardioprotective effect of zingerone against oxidative stress, inflammation, and apoptosis induced by cisplatin or gamma radiation in rats. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29736687&form=6&db=m Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29740316&form=6&db=m Lychee Seed Fraction Inhibits A?(1-42)-Induced Neuroinflammation in BV-2 Cells via NF-?B Signaling Pathway. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29742623&form=6&db=m Delayed treatment of propofol inhibits lipopolysaccharide-induced inflammation in microglia through the PI3K/PKB pathway. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29743919&form=6&db=m Ginsenoside Rg3 Sensitizes Colorectal Cancer to Radiotherapy through Downregulation of Proliferative and Angiogenic Biomarkers. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29745506&form=6&db=m [Role and mechanism of cAMP/Ca 2+ signal pathway in differentiation of bone marrow mesenchymal stem cells into neuronal cells induced by salidroside]. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29747629&form=6&db=m In vitro evaluation of the synergistic antioxidant and anti-inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29747742&form=6&db=m G protein-coupled estrogen receptor is involved in the anti-inflammatory effects of genistein in microglia. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29753822&form=6&db=m The protective role of selenium against cadmium-induced hepatotoxicity in laying hens: Expression of Hsps and inflammation-related genes and modulation of elements homeostasis. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29758489&form=6&db=m Fisetin inhibits the generation of inflammatory mediators in interleukin-1?-induced human lung epithelial cells by suppressing the NF-?B and ERK1/2 pathways. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29763880&form=6&db=m Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29765153&form=6&db=m COX-2 mediates pro-tumorigenic effects of PKC? in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29766429&form=6&db=m Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29769213&form=6&db=m Chemopreventive Efficacy of the Cyclooxygenase-2 (Cox-2) Inhibitor, Celecoxib, Is Predicted by Adenoma Expression of Cox-2 and 15-PGDH. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29772372&form=6&db=m Palmitate induces nitric oxide production and inflammatory cytokine expression in zebrafish. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29775228&form=6&db=m Uroprotective mechanism of quercetin against cyclophosphamide-induced urotoxicity: Effect on oxidative stress and inflammatory markers. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29775722&form=6&db=m Inflammatory and oxidative mechanisms potentiate bifenthrin-induced neurological alterations and anxiety-like behavior in adult rats. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29776235&form=6&db=m Predicting factors for locoregional failure of high-dose-rate brachytherapy for early-stage oral cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29782360&form=6&db=m A Phase II Study of Celecoxib With Irinotecan, 5-Fluorouracil, and Leucovorin in Patients With Previously Untreated Advanced or Metastatic Colorectal Cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29784301&form=6&db=m Two new farnesyl phenolic compounds with anti-inflammatory activities from Ganoderma duripora. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786649&form=6&db=m Kudzu Leaf Extract Suppresses the Production of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, Tumor Necrosis Factor-Alpha, and Interleukin-6 via Inhibition of JNK, TBK1 and STAT1 in Inflammatory Macrophages. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29788918&form=6&db=m Alterations in NO- and PGI2- dependent function in aorta in the orthotopic murine model of metastatic 4T1 breast cancer: relationship with pulmonary endothelial dysfunction and systemic inflammation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29792868&form=6&db=m AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29793499&form=6&db=m Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29794562&form=6&db=m Tumour-infiltrating lymphocytes, programmed death ligand 1 and cyclooxygenase-2 expression in skin melanoma of elderly patients: clinicopathological correlations. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29795479&form=6&db=m Role of Kupffer cells in the progression of CRC liver metastases after the first stage of ALPPS. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29800798&form=6&db=m Impact of structural alterations on the radiopharmacological profile of 18F-labeled pyrimidines as cyclooxygenase-2 (COX-2) imaging agents. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29804536&form=6&db=m Design, Synthesis and Biological Evaluation of New 1,3-diphenyl-3- (phenylamino)propan-1-ones as Selective Cyclooxygenase (COX-2) Inhibitors. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29805673&form=6&db=m Anesthetic drug propofol inhibits the expression of interleukin-6, interleukin-8 and cyclooxygenase-2, a potential mechanism for propofol in suppressing tumor development and metastasis. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29808459&form=6&db=m mPGES-1 and ALOX5/-15 in tumor-associated macrophages. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29843006&form=6&db=m Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29844659&form=6&db=m Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-?B/I?B? signaling pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29849793&form=6&db=m Expression profile of NF-?B regulated genes in sporadic colorectal cancer patients. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29850157&form=6&db=m Aspirin acts in esophageal cancer: a brief review. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29852926&form=6&db=m Fragile X-related protein 1 (FXR1) regulates cyclooxygenase-2 (COX-2) expression at the maternal?fetal interface. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29854347&form=6&db=m Role of Nonsteroidal Anti-inflammatory Drug in Treatment of Extra-abdominal Desmoid Tumors. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29857242&form=6&db=m Protective role of ?-carotene against oxidative stress and neuroinflammation in a rat model of spinal cord injury. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29858743&form=6&db=m Roles of prostaglandins in tumor-associated lymphangiogenesis with special reference to breast cancer. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29862139&form=6&db=m Transcorneal Electrical Stimulation Inhibits Retinal Microglial Activation and Enhances Retinal Ganglion Cell Survival After Acute Ocular Hypertensive Injury. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29864910&form=6&db=m Berberine suppresses growth and metastasis of endometrial cancer cells via miR-101/COX-2. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29872269&form=6&db=m Synthesis and evaluation of ortho-[18F] fluorocelecoxib for COX-2 cholangiocarcinoma imaging. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29874966&form=6&db=m Gellan gum macrobeads loaded with naproxen: The impact of various naturally derived polymers on pH-dependent behavior. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29879626&form=6&db=m Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29879892&form=6&db=m Investigation of Dracocephalum kotschyi Plant Extract on the Effective Inflammatory Transcription Factors and Mediators in Activated Macrophages. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29890469&form=6&db=m Steroidal alkaloid solanine A from Solanum nigrum Linn. exhibits anti-inflammatory activity in lipopolysaccharide/interferon ?-activated murine macrophages and animal models of inflammation. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29891794&form=6&db=m Polyphenols from Tamarix nilotica: LC?ESI-MSn Profiling and In Vivo Antifibrotic Activity. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29893307&form=6&db=m Evaluating the expression of cyclooxygenase-2 enzyme by immunohistochemistry in normal and tumoral tissue before and after neoadjuvant chemoradiotherapy in patients with esophageal cancer in Khorasan Province. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29898737&form=6&db=m Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29899846&form=6&db=m Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29901082&form=6&db=m Liquiritin suppresses UVB?induced skin injury through prevention of inflammation, oxidative stress and apoptosis through the TLR4/MyD88/NF??B and MAPK/caspase signaling pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29903983&form=6&db=m 4'-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-?B and NLRP3 Inflammasome Pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29904426&form=6&db=m Antinociceptive effects of dezocine on complete Freund's adjuvant-induced inflammatory pain in rats. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29906688&form=6&db=m In vitro and in vivo studies of gold(I) azolate/phosphane complexes for the treatment of basal like breast cancer. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29907781&form=6&db=m Attenuation of inflammatory responses by (+)-syringaresinol via MAP-Kinase-mediated suppression of NF-?B signaling in vitro and in vivo. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29913095&form=6&db=m Inhibition of LPS-induced inflammatory responses by Satureja hortensis extracts in J774.1 macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29916670&form=6&db=m Combinational Treatment Effect of Tetrahydrocurcumin and Celecoxib on Cervical Cancer Cell-Induced Tumor Growth and Tumor Angiogenesis in Nude Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29920283&form=6&db=m Rutin, a quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29923556&form=6&db=m Regulating the Golgi apparatus by co-delivery of a COX-2 inhibitor and Brefeldin A for suppression of tumor metastasis. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29926309&form=6&db=m Role of prostaglandins in tumor microenvironment. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928319&form=6&db=m Canine mammary tumors as a model for human disease. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29929569&form=6&db=m Physiologic and innate immunity responses to bacterial lipopolysaccharide administration in beef heifers supplemented with OmniGen-AF. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29932878&form=6&db=m COX-2 inhibition by celecoxib in epithelial ovarian cancer attenuates E-cadherin suppression through reduced Snail nuclear translocation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29933606&form=6&db=m The Antioxidant and Anti-Inflammatory Activities of 8-Hydroxydaidzein (8-HD) in Activated Macrophage-Like RAW264.7 Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29936588&form=6&db=m Eicosanoids and HB-EGF/EGFR in cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29942193&form=6&db=m The role of bile acids in cellular invasiveness of gastric cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29944876&form=6&db=m Hesperidin protects against stress induced gastric ulcer through regulation of peroxisome proliferator activator receptor gamma in diabetic rats. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29948145&form=6&db=m Molecular classification and subtype-specific characterization of skin cutaneous melanoma by aggregating multiple genomic platform data. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29957091&form=6&db=m Is Curcumin a Possibility to Treat Inflammatory Bowel Diseases? ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29958245&form=6&db=m Gentiopicroside protects neurons from astrocyte-mediated inflammatory injuries by inhibition of nuclear factor-?B and mitogen-activated protein kinase signaling pathways. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29966585&form=6&db=m a-Tocopherol modifies the expression of genes related to oxidative stress and apoptosis during invitro maturation and enhances the developmental competence of rabbit oocytes. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968808&form=6&db=m Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29969649&form=6&db=m Meroterpenoid dimers from Ganoderma cochlear and their cytotoxic and COX-2 inhibitory activities. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29970291&form=6&db=m Piperlongumine inhibits neuroinflammation via regulating NF-?B signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29977412&form=6&db=m Inhibition of the development of N-nitrosomethylbenzylamine-induced esophageal tumors in rats by strawberries and aspirin, alone and in combination. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29978476&form=6&db=m Plant galactolipid dLGG suppresses lung metastasis of melanoma through deregulating TNF-?-mediated pulmonary vascular permeability and circulating oxylipin dynamics in mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29999276&form=6&db=m Increased Expression of Thioredoxin-1 Binding Protein-2 in Placentas in Preeclampsia. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30002289&form=6&db=m Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-?B and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003391&form=6&db=m Differential expression of cyclooxygenase-2 and cyclin D1 in salivary gland tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003465&form=6&db=m Terminalia bellirica (Gaertn.) Roxb fruit exerts anti-inflammatory effect via regulating arachidonic acid pathway and pro-inflammatory cytokines in lipopolysaccharide-induced RAW 264.7 macrophages. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003735&form=6&db=m Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30008606&form=6&db=m Anti-inflammation and Anti-Cancer Activity of Ethanol Extract of Antarctic Freshwater Microalga, Micractinium sp. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30008836&form=6&db=m Value of combined detection of serum carcino-embryonic antigen, carbohydrate antigen 19-9 and cyclooxygenase-2 in the diagnosis of colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30020862&form=6&db=m IL-1? and IL-1? as alternative biomarkers for risk assessment and the prediction of skin sensitization potency. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30021393&form=6&db=m Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30022870&form=6&db=m Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and Inflammatory Changes in Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30025492&form=6&db=m Vinorelbine's anti-tumor actions may depend on the mitotic apoptosis, autophagy and inflammation: hypotheses with implications for chemo-immunotherapy of advanced cancers and pediatric gliomas. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30027502&form=6&db=m Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30031609&form=6&db=m HDAC9 promotes brain ischemic injury by provoking I?B?/NF-?B and MAPKs signaling pathways. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30031652&form=6&db=m Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30031824&form=6&db=m Daphnetin alleviates lipopolysaccharide/d-galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-?B, and the induction of autophagy. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034228&form=6&db=m Over-expression of nuclear factor-?B family genes and inflammatory molecules is related to chronic obstructive pulmonary disease. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30034467&form=6&db=m Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30049816&form=6&db=m RGS10 Regulates the Expression of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha through a G Protein-Independent Mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30051683&form=6&db=m COX-2 Expression in Breast Carcinoma with Correlation to Clinicopathological Parameters causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30070297&form=6&db=m Hydroxysafflor yellow A (HSYA) targets the NF-?B and MAPK pathways and ameliorates the development of osteoarthritis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30073924&form=6&db=m Celecoxib in Cancer Therapy and Prevention - Review. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30079321&form=6&db=m Quantitative analysis of COX-2 promoter methylation in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081353&form=6&db=m 1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082142&form=6&db=m The prognostic value of COX-2 expression on circulating tumor cells in nasopharyngeal carcinoma: A prospective analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082676&form=6&db=m Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30087797&form=6&db=m Evaluation of Cytotoxicity Effects of Chalcone Epoxide Analogues as a Selective COX-II Inhibitor in the Human Liver Carcinoma Cell Line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30090328&form=6&db=m Intravenous injection of l-BMAA induces a rat model with comprehensive characteristics of amyotrophic lateral sclerosis/Parkinson-dementia complex. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30096014&form=6&db=m Fermented Ganjangs (Soy Sauce and Sesame Sauce) Attenuates Colonic Carcinogenesis in Azoxymethane/Dextran Sodium Sulfate-Treated C57BL/6J Mice. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30102949&form=6&db=m Pyrethroid bifenthrin induces oxidative stress, neuroinflammation, and neuronal damage, associated with cognitive and memory impairment in murine hippocampus. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30103745&form=6&db=m Safflower polysaccharide inhibits the development of tongue squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30104530&form=6&db=m CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30106414&form=6&db=m Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients. An experience from Western Saudi Arabia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108663&form=6&db=m Tualang Honey Reduced Neuroinflammation and Caspase-3 Activity in Rat Brain after Kainic Acid-Induced Status Epilepticus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108767&form=6&db=m Structure-activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009-2016). causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108969&form=6&db=m Design, synthesis and biological evaluation of novel 1,3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30118847&form=6&db=m Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-l-Leucine and its cytotoxicity for normal and cancer human cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30119183&form=6&db=m Ameliorative effects of indomethacin at different concentrations on endothelial insulin resistance through two distinct pathways. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30122897&form=6&db=m Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30123124&form=6&db=m In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127129&form=6&db=m Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30127893&form=6&db=m Decreased expression level and DNA-binding activity of specificity protein 1 via cyclooxygenase-2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation-resistant lung cancer cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30131302&form=6&db=m Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30137286&form=6&db=m Rectal Insulin Instillation Inhibits Inflammation and Tumor Development in Chemically Induced Colitis. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30143023&form=6&db=m Association between cyclooxygenase-2 (COX-2) 8473 T?>?C polymorphism and cancer risk: a meta-analysis and trial sequential analysis. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30144515&form=6&db=m Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149323&form=6&db=m Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149368&form=6&db=m Pharmacological and dietary factors in prevention of colorectal cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149424&form=6&db=m Smallanthus sonchifolius leaf attenuates neuroinflammation. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149753&form=6&db=m Ethanol Extract of Lilium Bulbs Plays an Anti-Inflammatory Role by Targeting the IKK[Formula: see text]/[Formula: see text]-Mediated NF-[Formula: see text]B Pathway in Macrophages. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149754&form=6&db=m Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30152847&form=6&db=m Galangin protects human rheumatoid arthritis fibroblast?like synoviocytes via suppression of the NF??B/NLRP3 pathway. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30153288&form=6&db=m Seminal plasma modulates the immune-cytokine network in the porcine uterine tissue and pre-ovulatory follicles. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30154906&form=6&db=m The Novel Nutraceutical KJS018A Prevents Hepatocarcinogenesis Promoted by Inflammation. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155492&form=6&db=m Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-?B Pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30156477&form=6&db=m Resveratrol attenuates brain damage in permanent focal cerebral ischemia via activation of PI3K/Akt signaling pathway in rats. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30160278&form=6&db=m Downregulating PI3K/Akt/NF-?B signaling with allicin for ameliorating the progression of osteoarthritis: in vitro and vivo studies. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30174703&form=6&db=m Effect of Orally Administered Atractylodes macrocephala Koidz Water Extract on Macrophage and T Cell Inflammatory Response in Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30182439&form=6&db=m Celecoxib alleviates AKT/c-Met-triggered rapid hepatocarcinogenesis by suppressing a novel COX-2/AKT/FASN cascade. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30185893&form=6&db=m A systematic review and meta-analysis of prognostic biomarkers in resectable esophageal adenocarcinomas. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30195730&form=6&db=m Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30196771&form=6&db=m Cyclooxygenase-2 interacts with MMP and FGF pathways to promote epimorphic regeneration in lizard Hemidactylus flaviviridis. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30201038&form=6&db=m Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30201763&form=6&db=m Discovery and therapeutic exploitation of mechanisms of resistance to MET inhibitors in glioblastoma. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30201855&form=6&db=m Biogenic Polyphosphate Nanoparticles from a Marine Cyanobacterium Synechococcus sp. PCC 7002: Production, Characterization, and Anti-Inflammatory Properties In Vitro. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30201883&form=6&db=m Brain Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30203524&form=6&db=m LINC00657 expedites neuropathic pain development by modulating miR-136/ZEB1 axis in a rat model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30203673&form=6&db=m Ameliorative effect of selenium nanoparticles and fish oil on cisplatin and gamma irradiation-induced nephrotoxicity in male albino rats. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30210347&form=6&db=m Water Soluble Antioxidative Crude Polysaccharide From Russula senecis Elicits TLR Modulated NF-?B Signaling Pathway and Pro-inflammatory Response in Murine Macrophages. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30213621&form=6&db=m Peucedani Japonici Radix ameliorates lipopolysaccharide-induced neuroinflammation by regulating microglial responses. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30213642&form=6&db=m Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-?b and p38 pathways in zebrafish. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30223141&form=6&db=m COX-2 Inhibition mediated anti-angiogenic activatable prodrug potentiates cancer therapy in preclinical models. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30223923&form=6&db=m Immunomodulatory and anti-inflammatory effects of total flavonoids of Astragalus by regulating NF-?B and MAPK signalling pathways in RAW 264.7 macrophages. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30227591&form=6&db=m Isolation of Novel Sesquiterpeniods and Anti-neuroinflammatory Metabolites from Nardostachys jatamansi. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30227622&form=6&db=m Sex-Mediated Differences in LPS Induced Alterations of TNF?, IL-10 Expression, and Prostaglandin Synthesis in Primary Astrocytes. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231491&form=6&db=m The Dynamic Changes of Gut Microbiota in Muc2 Deficient Mice. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30231628&form=6&db=m Leaky brain in neurological and psychiatric disorders: Drivers and consequences. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30232626&form=6&db=m Effect of cold plasma on periodontal wound healing-an in vitro study. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30235825&form=6&db=m Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-?B-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30237731&form=6&db=m High glucose induces a priming effect in macrophages and exacerbates the production of pro-inflammatory cytokines after a challenge. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30241403&form=6&db=m Hepatoprotective Effect of Ugonin M, A Helminthostachyszeylanica Constituent, on Acetaminophen-Induced Acute Liver Injury in Mice. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30243628&form=6&db=m Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30245266&form=6&db=m Omentin-1 protects against bleomycin-induced acute lung injury. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30245604&form=6&db=m Amelioration of the Protein Expression of Cox2, NF?B, and STAT-3 by Some Antioxidants in the Liver of Sodium Fluoride-Intoxicated Rats. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30246366&form=6&db=m Therapeutical effects of vaccine from Trypanosoma cruzi amastigote surface protein 2 by simultaneous inoculation with live parasites. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30248332&form=6&db=m Time dependent neuroprotection of dexamethasone in experimental focal cerebral ischemia: the involvement of NF-?B pathways. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30251218&form=6&db=m Saikosaponin B2 Suppresses Inflammatory Responses Through IKK/I?B?/NF-?B Signaling Inactivation in LPS-Induced RAW 264.7 Macrophages. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30254182&form=6&db=m Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30257377&form=6&db=m IL-1? reduces cardiac lymphatic muscle contraction via COX-2 and PGE2 induction: Potential role in myocarditis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30259979&form=6&db=m Blockade of NEAT1 represses inflammation response and lipid uptake via modulating miR-342-3p in human macrophages THP-1 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30260024&form=6&db=m Associations between the cyclooxygenase-2 expression in circulating tumor cells and the clinicopathological features of patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30263093&form=6&db=m Modulation of genomic and epigenetic end-points by celecoxib. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30263306&form=6&db=m Anti-inflammatory effect of birsonimadiol from seeds of Byrsonima crassifolia. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30265586&form=6&db=m Glucocorticoids use in kidney transplant setting. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30269738&form=6&db=m Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT-116 cells through down-regulation of prostaglandin E2 receptor EP4. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30272289&form=6&db=m Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30273050&form=6&db=m Triticum aestivum Sprouts Extract Inhibits Azoymethane (AOM)/Dextran Sodium Sulfate (DSS)-Induced Colon Carcinogenesis in Mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30280446&form=6&db=m Oligonol, a low-molecular-weight polyphenol derived from lychee peel, attenuates diabetes-induced pancreatic damage by inhibiting inflammatory responses via oxidative stress-dependent mitogen-activated protein kinase/nuclear factor-kappa B signaling. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30284675&form=6&db=m Ethanol via Regulation of NF-?B/p53 Signaling Pathway Increases Manganese-Induced Inflammation and Apoptosis in Hypothalamus of Rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30288078&form=6&db=m Inflammatory gene mRNA expression in human peripheral blood and its association with colorectal cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30288860&form=6&db=m Loganin prevents BV-2 microglia cells from A?1-42 -induced inflammation via regulating TLR4/TRAF6/NF-?B axis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30289294&form=6&db=m Sex Differences in the Central and Peripheral Manifestations of Ischemia-induced Heart Failure in Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30291495&form=6&db=m Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30291805&form=6&db=m Perioperative biobehavioral interventions to prevent cancer recurrence through combined inhibition of ?-adrenergic and cyclooxygenase 2 signaling. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30298817&form=6&db=m Anti-inflammatory effects of olive-derived hydroxytyrosol on lipopolysaccharide-induced inflammation in RAW264.7 cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30301267&form=6&db=m Citrus aurantium L. and Its Flavonoids Regulate TNBS-Induced Inflammatory Bowel Disease through Anti-Inflammation and Suppressing Isolated Jejunum Contraction. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30311123&form=6&db=m Vitex negundo and its medicinal value. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30312731&form=6&db=m Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30314310&form=6&db=m Cyclooxygenase-1 (COX-1) and COX-1 Inhibitors in Cancer: A Review of Oncology and Medicinal Chemistry Literature. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30314513&form=6&db=m Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30314699&form=6&db=m lncRNA HOTAIR upregulates COX-2 expression to promote invasion and migration of nasopharyngeal carcinoma by interacting with miR-101. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30318012&form=6&db=m NADPH Oxidase as a Target for Modulation of Radiation Response; Implications to Carcinogenesis and Radiotherapy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30319623&form=6&db=m Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30320140&form=6&db=m Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30320514&form=6&db=m Anti-inflammatory potential of Trifolium pratense L. leaf extract in LPS-stimulated RAW264.7 cells and in a rat model of carrageenan-induced inflammation. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30325206&form=6&db=m Natural products and their derivatives as cyclooxygenase-2 inhibitors. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30326393&form=6&db=m ?-glutamylcysteine exhibits anti-inflammatory effects by increasing cellular glutathione level. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30327995&form=6&db=m A Novel and Selective p38 Mitogen-Activated Protein Kinase Inhibitor Attenuates LPS-Induced Neuroinflammation in BV2 Microglia and a Mouse Model. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333153&form=6&db=m Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30337810&form=6&db=m AKT-targeted anti-inflammatory activity of Panax ginseng calyx ethanolic extract. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30339710&form=6&db=m Expression analysis of cyclooxygenase-2 in patients suffering from esophageal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30340655&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 (COX-2) is not associated with tumor grade in feline meningiomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30341914&form=6&db=m Cyclooxygenase-2 in cancer: A review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30347478&form=6&db=m NF-?B activation mediates LPS-or zymosan-induced hypotension and inflammation reversed by BAY61-3606, a selective Syk inhibitor, in rat models of septic and non-septic shock. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30347752&form=6&db=m The Protective Effect of Polygonum cuspidatum (PCE) Aqueous Extract in a Dry Eye Model. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30349293&form=6&db=m Complete response associated with lenalidomide and celecoxib in a case of primary refractory Hodgkin lymphoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30362831&form=6&db=m Coffee, but Neither Decaffeinated Coffee nor Caffeine, Elicits Chemoprotection Against a Direct Carcinogen in the Colon of Wistar Rats. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367494&form=6&db=m PROSTAGLANDIN E2 stimulates cancer-related phenotypes in prostate cancer PC3 cells through cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30372880&form=6&db=m Ameliorative effect of Alnus japonica ethanol extract on colitis through the inhibition of inflammatory responses and attenuation of intestinal barrier disruption in vivo and in vitro. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30381122&form=6&db=m [Inhibition of demethylation of protein phosphatase 2A catalytic subunit (PP2Ac) promotes M1 polarization of macrophages]. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30384258&form=6&db=m Dihomo-?-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30384444&form=6&db=m Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30389468&form=6&db=m Acridocarpus Smeathmannii (DC.) Guill. & Perr. Root enhanced reproductive behavior and sexual function in male wistar rats: Biochemical and pharmacological mechanisms. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30391531&form=6&db=m Adipose tissue contributes to hepatic pro-inflammatory response when dietary fish oil is replaced by vegetable oil in large yellow croaker (Larimichthys crocea): An ex vivo study. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30392422&form=6&db=m Anti-inflammatory effects of shikonin in human periodontal ligament cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396040&form=6&db=m A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396718&form=6&db=m The protective effects of Aquilariae Lignum Resinatum extract on 5-Fuorouracil-induced intestinal mucositis in mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396759&form=6&db=m In vivo evaluation of [11C]TMI, a COX-2 selective PET tracer, in baboons. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30400322&form=6&db=m Kaempferia parviflora Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti-Propionibacterium acnes Activity. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402117&form=6&db=m An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF-?B Signaling. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402225&form=6&db=m Alleviation effects of natural volatile organic compounds from Pinus densiflora and Chamaecyparis obtusa on systemic and pulmonary inflammation. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402808&form=6&db=m Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30404129&form=6&db=m Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-?B Pathway and Activating Nrf-2/HO-1 Pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30405049&form=6&db=m Pediococcus pentosaceus-Fermented Cordyceps militaris Inhibits Inflammatory Reactions and Alleviates Contact Dermatitis. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30408225&form=6&db=m High PTGS2 expression in post-neoadjuvant chemotherapy-treated oesophageal adenocarcinoma is associated with improved survival: a population-based cohort study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30408459&form=6&db=m The possible ameliorative effect of simvastatin versus sulfasalazine on acetic acid induced ulcerative colitis in adult rats. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30415164&form=6&db=m Aloperine suppresses allergic airway inflammation through NF-?B, MAPK, and Nrf2/HO-1 signaling pathways in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30417321&form=6&db=m Withaferin A Protects Against High-Fat Diet-Induced Obesity Via Attenuation of Oxidative Stress, Inflammation, and Insulin Resistance. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30417459&form=6&db=m Inhibition of PI3K/Akt/NF-?B signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30421246&form=6&db=m Trigonelline protects hippocampus against intracerebral A?(1-40) as a model of Alzheimer's disease in the rat: insights into underlying mechanisms. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30424016&form=6&db=m Peroxisome Proliferator-Activated Receptors (PPAR)? Agonists as Master Modulators of Tumor Tissue. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30445673&form=6&db=m Design of a 3D BMP-2-Delivering Tannylated PCL Scaffold and Its Anti-Oxidant, Anti-Inflammatory, and Osteogenic Effects In Vitro. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30447529&form=6&db=m The novel N-methyl-d-aspartate receptor antagonist MN-08 ameliorates lipopolysaccharide-induced acute lung injury in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448175&form=6&db=m Thioredoxin-interacting protein-derived peptide (TN13) inhibits LPS-induced inflammation by inhibiting p38 MAPK signaling. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30460934&form=6&db=m A novel rat model of seminal vesiculitis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30468157&form=6&db=m Lysozyme-Antimicrobial Peptide Fusion Protein Promotes the Diabetic Wound Size Reduction in Streptozotocin (STZ)-Induced Diabetic Rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30477664&form=6&db=m Immunohistochemical Analysis of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha in Periapical Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30477960&form=6&db=m The investigation of the protective effects of nimesulide on experimental testicular ischemia-reperfusion injury in rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30480806&form=6&db=m c-Met inhibition is required for the celecoxib-attenuated stemness property of human colorectal cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30484108&form=6&db=m Expression of long non-coding RNA CCHE1 in colorectal carcinoma: correlations with clinicopathological features and ERK/COX-2 pathway. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30488751&form=6&db=m Protective effect of sesamin in lipopolysaccharide-induced mouse model of acute kidney injury via attenuation of oxidative stress, inflammation, and apoptosis. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30488803&form=6&db=m Molecular Mechanisms of Curcumin in Neuroinflammatory Disorders: A Mini Review of Current Evidences. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30488858&form=6&db=m To evaluate immunoreactivity of cyclooxygenase-2 in cases of endometrial carcinoma and correlate it with expression of p53 and vascular endothelial growth factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30497427&form=6&db=m Mammographic density and breast tissue expression of inflammatory markers, growth factors, and vimentin. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502652&form=6&db=m Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPAR?/Nrf2/NF-?B signaling pathway. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502795&form=6&db=m Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30516514&form=6&db=m MEDICAL BASIS OF DIABETIC NEUROPATHY FORMATION (REVIEW). causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30518262&form=6&db=m (±) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from Ganoderma cochlear. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30521857&form=6&db=m Nucleoside and N-acetyldopamine derivatives from the insect Aspongopus chinensis. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30523664&form=6&db=m Treatment of actinic keratosis through inhibition of cyclooxygenase-2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30527567&form=6&db=m Successful treatment of a recurrent chest wall desmoid tumor with cyclooxygenase-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30530291&form=6&db=m Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-?, NF-?B, and COX-2 levels, and upregulation of TFF-2 levels. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30539520&form=6&db=m Approach the Invasive Potential with Hurthle Cell Tumors of Thyroid. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30542442&form=6&db=m Berberine alleviates amyloid ?25-35-induced inflammatory response in human neuroblastoma cells by inhibiting proinflammatory factors. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30546308&form=6&db=m Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30551534&form=6&db=m Hydroxysafflor yellow A suppresses angiogenesis of hepatocellular carcinoma through inhibition of p38 MAPK phosphorylation. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30559850&form=6&db=m Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30560261&form=6&db=m Experimental and theoretical investigations of cyclometalated ruthenium(ii) complex containing CCC-pincer and anti-inflammatory drugs as ligands: synthesis, characterization, inhibition of cyclooxygenase and in vitro cytotoxicity activities in various cancer cell lines. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30562372&form=6&db=m NF-?B p65 and p105 implicate in interleukin 1?-mediated COX-2 expression in melanoma cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30562763&form=6&db=m Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30563131&form=6&db=m Hydroxytyrosol Exerts Anti-Inflammatory and Anti-Oxidant Activities in a Mouse Model of Systemic Inflammation. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30567534&form=6&db=m Dihomo-?-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30574053&form=6&db=m Pretreatment with Lactobacillus reuteri F-9-35 attenuates ethanol-induced gastric injury in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30579255&form=6&db=m The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30580362&form=6&db=m Cyclooxygenase-2 expression in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30590319&form=6&db=m Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-?B pathway in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30591531&form=6&db=m Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30597306&form=6&db=m Amygdalin attenuates acute liver injury induced by D-galactosamine and lipopolysaccharide by regulating the NLRP3, NF-?B and Nrf2/NQO1 signalling pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30599908&form=6&db=m Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30603552&form=6&db=m In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30610615&form=6&db=m Lignans from Saururus chinensis exhibit anti-inflammatory activity by influencing the Nrf2/HO-1 activation pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30610879&form=6&db=m Vanillin protects the blood-milk barrier and inhibits the inflammatory response in LPS-induced mastitis in mice. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30612458&form=6&db=m In Vitro and In Vivo Protective Effects of Flavonoid-Enriched Lotus Seedpod Extract on Lipopolysaccharide-Induced Hepatic Inflammation. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30616083&form=6&db=m Zeaxanthin exerts protective effects on acetic acid-induced colitis in rats via modulation of pro-inflammatory cytokines and oxidative stress. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30618533&form=6&db=m Cyclooxygenase-2 expression in actinic keratosis. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30618728&form=6&db=m In vivo and in vitro Approach to Anti-arthritic and Anti-inflammatory Effect of Crocetin by Alteration of Nuclear Factor-E2-Related Factor 2/hem Oxygenase (HO)-1 and NF-?B Expression. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30620132&form=6&db=m Screening and isolation of cyclooxygenase-2 inhibitors from Trifolium pratense L. via ultrafiltration, enzyme-immobilized magnetic beads, semi-preparative high-performance liquid chromatography and high-speed counter-current chromatography. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30621304&form=6&db=m Anti-Colitic Effects of Ethanol Extract of Persea americana Mill. through Suppression of Pro-Inflammatory Mediators via NF-?B/STAT3 Inactivation in Dextran Sulfate Sodium-Induced Colitis Mice. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30627539&form=6&db=m Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30637164&form=6&db=m Amelioration of experimental autoimmune encephalomyelitis by Ishige okamurae. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30637814&form=6&db=m Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4-MyD88-mediated NF-?B and MAPK signaling pathways. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30638861&form=6&db=m Expression and association of carbonic anhydrase IX and cyclooxygenase-2 in colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641217&form=6&db=m Mitochondrial targeting of TR3 is involved in TPA induced apoptosis in breast cancer cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30644158&form=6&db=m Follistatin-like protein 1 (FSTL1) promotes chondrocyte expression of matrix metalloproteinase and inflammatory factors via the NF-?B pathway. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30650553&form=6&db=m n-6 Linoleic Acid Induces Epigenetics Alterations Associated with Colonic Inflammation and Cancer. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651530&form=6&db=m Metastasis-Associated 1 (MTA1) Gene Expression Promotes Angiogenesis in Mouse Xenografts from Human Non-Small Cell Lung Cancer (NSCLC) Cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651803&form=6&db=m Preoperative intravenous flurbiprofen reduces postoperative pain and inflammatory cytokines in elderly patients after hip arthroplasty. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30651867&form=6&db=m Effects of febuxostat on serum cytokines IL-1, IL-4, IL-6, IL-8, TNF-? and COX-2. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30653946&form=6&db=m Dietary canolol induces apoptosis in human cervical carcinoma HeLa cells through ROS-MAPK mediated mitochondrial signaling pathway: In vitro and in vivo. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662635&form=6&db=m Tepoxalin a dual 5-LOX-COX inhibitor and erlotinib an EGFR inhibitor halts progression of gastric cancer in tumor xenograft mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30664898&form=6&db=m Protocatechuic acid improves functional recovery after spinal cord injury by attenuating blood-spinal cord barrier disruption and hemorrhage in rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30665040&form=6&db=m S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671980&form=6&db=m Pharmacological inhibition of TLR4/NF-?B with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30674365&form=6&db=m Significance of immunohistochemical overexpression of cyclooxygenase-2 in overall and disease-free survival of oral squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30674535&form=6&db=m An ARC-regulated IL1?/Cox-2/PGE2/?-catenin/ARC circuit controls leukemia-microenvironment interactions and confers drug resistance in AML. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30678325&form=6&db=m Kaempferol Attenuates LPS-Induced Striatum Injury in Mice Involving Anti-Neuroinflammation, Maintaining BBB Integrity, and Down-Regulating the HMGB1/TLR4 Pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30683818&form=6&db=m The cyclooxygenase-2/prostaglandin E2 pathway and its role in the pathogenesis of human and dog hematological malignancies. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30690444&form=6&db=m Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30693991&form=6&db=m Anti-inflammatory effects of chemical components from Ginkgo biloba L. male flowers on lipopolysaccharide-stimulated RAW264.7 macrophages. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30700940&form=6&db=m Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30710734&form=6&db=m Suppression of Src and Syk in the NF-?B signaling pathway by Olea europaea methanol extract is leading to its anti-inflammatory effects. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30713782&form=6&db=m Mannan-binding lectin suppresses growth of hepatocellular carcinoma by regulating hepatic stellate cell activation via the ERK/COX-2/PGE2 pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30715649&form=6&db=m Cyclooxygenase (COX) Inhibition by Acetyl Salicylic Acid (ASA) Enhances Antitumor Effects of Nitric Oxide in Glioblastoma In Vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30726934&form=6&db=m MicroRNA-708 activation by glucocorticoid receptor agonists regulate breast cancer tumorigenesis and metastasis via downregulation of NF-?B signaling. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30734970&form=6&db=m Farrerol attenuates MPP+ -induced inflammatory response by TLR4 signaling in a microglia cell line. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737411&form=6&db=m Alkali treated antioxidative crude polysaccharide from Russula alatoreticula potentiates murine macrophages by tunning TLR/NF-?B pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30738987&form=6&db=m Identification of narciclasine from Lycoris radiata (L'Her.) Herb. and its inhibitory effect on LPS-induced inflammatory responses in macrophages. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30739913&form=6&db=m Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740154&form=6&db=m The Immunomodulatory Activities of Picria Fel-Terrae Lour Herbs towards RAW 264.7 Cells. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740619&form=6&db=m Water-Soluble Arginyl-Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-?B and JNK MAPK Signaling in Adult Mice Challenged by LPS. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740906&form=6&db=m Activation of PTGS2/NF-?B signaling pathway enhances radiation resistance of glioma. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740911&form=6&db=m Isoalantolactone inhibits IKK? kinase activity to interrupt the NF-?B/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30747998&form=6&db=m Cyclooxygenase-2 in gastrointestinal malignancies. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30761249&form=6&db=m Cyclooxygenase-2 expression correlates with development, progression, metastasis, and prognosis of osteosarcoma: a meta-analysis and trial sequential analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30767381&form=6&db=m The selective cyclooxygenase-2 inhibitor mavacoxib (Trocoxcil™) exerts anti-tumour effects in-vitro independent of cyclooxygenase-2 expression levels. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30772740&form=6&db=m Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30783437&form=6&db=m The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30794925&form=6&db=m Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30803507&form=6&db=m ?-Alanine supplementation reduces anxiety and increases neurotrophin expression in both young and older rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30810331&form=6&db=m Altered expression of COX-2 and TNF-? in patients with hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30813721&form=6&db=m Anthocyanins from Lycium ruthenicum Murr. Ameliorated d-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30819896&form=6&db=m COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30826588&form=6&db=m Development of a series of 4-hydroxycoumarin platinum(IV) hybrids as antitumor agents: Synthesis, biological evaluation and action mechanism investigation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30826660&form=6&db=m Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30843344&form=6&db=m Screening and isolation of cyclooxygenase-2 inhibitors from the stem bark of Phellodendron amurense Ruprecht by ultrafiltration with liquid chromatography and tandem mass spectrometry, and complex chromatography. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30845292&form=6&db=m Immunoexpression of p53 and COX-2 in basal cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30845693&form=6&db=m Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30852764&form=6&db=m Medicinal plants and their isolated phytochemicals for the management of chemotherapy-induced neuropathy: therapeutic targets and clinical perspective. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30858204&form=6&db=m Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30862036&form=6&db=m Cyclooxygenase-2-Mediated Up-Regulation of Mitochondrial Transcription Factor A Mitigates the Radio-Sensitivity of Cancer Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30862297&form=6&db=m Nickel-refining dust regulates the expression of inflammatory factors in NIH/3T3 cells. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864851&form=6&db=m Chemopreventive Activity of Red Ginseng Oil in a Mouse Model of Azoxymethane/Dextran Sulfate Sodium-Induced Inflammation-Associated Colon Carcinogenesis. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30874870&form=6&db=m Elucidation of the molecular mechanism underlying the anti-inflammatory activity of an effective and safe bipyrazole-based compound. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30875793&form=6&db=m Liver Injury Induced by Carbon Tetrachloride in Mice Is Prevented by the Antioxidant Capacity of Anji White Tea Polyphenols. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30877972&form=6&db=m Design, synthesis and evaluation of novel diaryl-1,5-diazoles derivatives bearing morpholine as potent dual COX-2/5-LOX inhibitors and antitumor agents. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30884126&form=6&db=m Taiwanin C elicits apoptosis in arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cell carcinoma cells and hinders proliferation via epidermal growth factor receptor/PI3K suppression. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30891836&form=6&db=m Isofraxidin attenuates IL-1?-induced inflammatory response in human nucleus pulposus cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30893857&form=6&db=m Correlation of BRAF Variant V595E, Breed, Histological Grade and Cyclooxygenase-2 Expression in Canine Transitional Cell Carcinomas. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30899728&form=6&db=m Antioxidative and anti-inflammatory effect of Phellinus igniarius on RAW 264.7 macrophage cells. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30900666&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30901885&form=6&db=m Oenanthe Javanica Extract Protects Mouse Skin from UVB Radiation via Attenuating Collagen Disruption and Inflammation. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30905077&form=6&db=m Modulative effect of a new hydrazide derivative on wheat-induced pulmonary inflammation in rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30907747&form=6&db=m Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30911291&form=6&db=m HMG-CoA Reductase Inhibitors Attenuate Neuronal Damage by Suppressing Oxygen Glucose Deprivation-Induced Activated Microglial Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30924375&form=6&db=m Anti-inflammatory role of tempol (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl) in nephroprotection. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930291&form=6&db=m Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson's disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930978&form=6&db=m Positive acceleration adaptive training attenuates gastric ischemia-reperfusion injury through COX-2 and PGE2 expression. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30936996&form=6&db=m Resveratrol downregulates the TLR4 signaling pathway to reduce brain damage in a rat model of focal cerebral ischemia. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30941311&form=6&db=m Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30941969&form=6&db=m Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30942801&form=6&db=m Peiminine inhibits the IL-1? induced inflammatory response in mouse articular chondrocytes and ameliorates murine osteoarthritis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30943209&form=6&db=m Connexin 43 plays an important role in the transformation of cholangiocytes with Clonochis sinensis excretory-secretory protein and N-nitrosodimethylamine. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30944711&form=6&db=m Computational and pharmacological investigation of novel 1,5-diaryl-1,4-pentadien-3-one derivatives for analgesic, anti-inflammatory and anticancer potential. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30946805&form=6&db=m Dauricine negatively regulates lipopolysaccharide- or cecal ligation and puncture-induced inflammatory response via NF-?B inactivation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951758&form=6&db=m Synthesis and evaluation of novel D-ring substituted steroidal pyrazolines as potential anti-inflammatory agents. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30955505&form=6&db=m Effect of functional oils on the immune response of broilers challenged with Eimeria spp. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30967907&form=6&db=m Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30972191&form=6&db=m Alterations of COX-2, HER-2/neu and E-Cadherin protein expression in the prostatic adenocarcinoma: preliminary findings. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30980807&form=6&db=m Anti-inflammatory functions of the CDC25 phosphatase inhibitor BN82002 via targeting AKT2. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30982333&form=6&db=m Cyclo-oxygenase-2 expression is associated with mean standardised uptake value on 18F-Fluorodeoxyglucose positron emission tomography in oesophageal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30983975&form=6&db=m The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30987191&form=6&db=m Future Aspects for Cannabinoids in Breast Cancer Therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30991046&form=6&db=m (-)-Myrtenol accelerates healing of acetic acid-induced gastric ulcers in rats and in human gastric adenocarcinoma cells. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31000626&form=6&db=m Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31004597&form=6&db=m 6-Gingerol abates benzo[a]pyrene-induced colonic injury via suppression of oxido-inflammatory stress responses in BALB/c mice. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31009406&form=6&db=m Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31018145&form=6&db=m Analgesic and anti-inflammatory effects and molecular mechanisms of Kadsura heteroclita stems, an anti-arthritic Chinese Tujia ethnomedicinal herb. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31020375&form=6&db=m Involvement of Nrf2/HO-1 antioxidant signaling and NF-?B inflammatory response in the potential protective effects of vincamine against methotrexate-induced nephrotoxicity in rats: cross talk between nephrotoxicity and neurotoxicity. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31026991&form=6&db=m Anti-Inflammatory Effects of Step Electrical Stimulation on Complete Freund's Adjuvant (CFA) Induced Rheumatoid Arthritis Rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31037830&form=6&db=m Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31038736&form=6&db=m Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31040782&form=6&db=m The Protective Effect of Magnolol in Osteoarthritis: In vitro and in vivo Studies. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31046874&form=6&db=m Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31049139&form=6&db=m Cordyceps militaris Improves Chronic Kidney Disease by Affecting TLR4/NF-?B Redox Signaling Pathway. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31052167&form=6&db=m Dihydropyrazole Derivatives Containing Benzo Oxygen Heterocycle and Sulfonamide Moieties Selectively and Potently Inhibit COX-2: Design, Synthesis, and Anti-Colon Cancer Activity Evaluation. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31063976&form=6&db=m The first case of primary hypertrophic osteoarthropathy with soft tissue giant tumors caused by HPGD loss-of-function mutation. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31064095&form=6&db=m 4,5-Diaryl 3(2H)Furanones: Anti-Inflammatory Activity and Influence on Cancer Growth. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31069605&form=6&db=m Zinc and iron complexes of oleanolic acid, (OA) attenuate allergic airway inflammation in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31075526&form=6&db=m - diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31092422&form=6&db=m Hyperthermia Suppresses Post - In Vitro Proliferation and Tumor Growth in Murine Malignant Melanoma and Colon Carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31095896&form=6&db=m Dose-dependent study of effects of 532-nm continuous wave laser on rat skin: A mechanistic insight. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31100475&form=6&db=m The extracellular role of Ref-1 as anti-inflammatory function in lipopolysaccharide-induced septic mice. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31103492&form=6&db=m d-Limonene protects PC12 cells against corticosterone-induced neurotoxicity by activating the AMPK pathway. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31113339&form=6&db=m Endogenous BMP-4/ROS/COX-2 Mediated IPC and Resveratrol Alleviated Brain Damage. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31113465&form=6&db=m Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31113934&form=6&db=m TFAP2B overexpression contributes to tumor growth and progression of thyroid cancer through the COX-2 signaling pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31114336&form=6&db=m Suppressing growth and invasion of human hepatocellular carcinoma cells by celecoxib through inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31116311&form=6&db=m Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118754&form=6&db=m Mast cell stabilizer ketotifen reduces hyperalgesia in a rodent model of surgically induced endometriosis. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31118953&form=6&db=m Protium javanicum Burm. Methanol Extract Attenuates LPS-Induced Inflammatory Activities in Macrophage-Like RAW264.7 Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31121820&form=6&db=m Zerumbone Protects against Carbon Tetrachloride (CCl4)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4/NF-?B/COX-2 Pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31122736&form=6&db=m Nonsteroidal anti-inflammatory drugs and pain in cancer patients: a systematic review and reappraisal of the evidence. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31127990&form=6&db=m Effect of TGF-?1 on Apoptosis of Colon Cancer Cells Via the ERK Signaling Pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31132889&form=6&db=m Selective COX-2 inhibitors as anticancer agents: a patent review (2014-2018). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31133878&form=6&db=m Stressors Due to Handling Impair Gut Immunity in Meagre (Argyrosomus regius): The Compensatory Role of Dietary L-Tryptophan. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31136035&form=6&db=m Extracellular-signal-regulated kinase/mitogen-activated protein kinase signaling as a target for cancer therapy: an updated review. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31141661&form=6&db=m Core-Shell Distinct Nanodrug Showing On-Demand Sequential Drug Release To Act on Multiple Cell Types for Synergistic Anticancer Therapy. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31142060&form=6&db=m Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31147469&form=6&db=m JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31151271&form=6&db=m An Algal Metabolite-Based PPAR-? Agonist Displayed Anti-Inflammatory Effect via Inhibition of the NF-?B Pathway. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31152978&form=6&db=m ?-Ecdysone suppresses inflammatory responses via the Nrf2 pathway in lipopolysaccharide-stimulated RAW 264.7 cells. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31154267&form=6&db=m A selective CB2 agonist protects against the inflammatory response and joint destruction in collagen-induced arthritis mice. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31155246&form=6&db=m Lactobacillus plantarum CAU1055 ameliorates inflammation in lipopolysaccharide-induced RAW264.7 cells and a dextran sulfate sodium-induced colitis animal model. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31157709&form=6&db=m Aerobic Training and Green Tea Extract Protect against NMU-induced Prostate Cancer. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31162144&form=6&db=m Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2). causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31163615&form=6&db=m Anti-Inflammatory Effects of 5?,8?-Epidioxycholest-6-en-3?-ol, a Steroidal Endoperoxide Isolated from Aplysia depilans, Based on Bioguided Fractionation and NMR Analysis. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31165450&form=6&db=m Protective effects of zingerone on cisplatin-induced nephrotoxicity in female rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31172046&form=6&db=m Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31179071&form=6&db=m Effects of glycyrrhizin on lipopolysaccharide-induced acute lung injury in a mouse model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31179232&form=6&db=m Increased COX-2 Immunostaining in Urothelial Carcinoma of the Urinary Bladder Is Associated with Invasiveness and Poor Prognosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31179755&form=6&db=m The Adjuvant Effect of Squalene, an Active Ingredient of Functional Foods, on Doxorubicin-Treated Allograft Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186277&form=6&db=m Protective effect of Cordyceps sinensis extract on lipopolysaccharide-induced acute lung injury in mice. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186753&form=6&db=m EGFR, but not COX-2, protein in resected pancreatic ductal adenocarcinoma is associated with poor survival. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31187468&form=6&db=m Prognostic Value of Accumulative Expression of COX-2 and p53 in Small and Diffuse Large B Cell Lymphoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31197431&form=6&db=m Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-?B inflammatory cascade. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201704&form=6&db=m Selenium alleviates cadmium-induced inflammation and meat quality degradation via antioxidant and anti-inflammation in chicken breast muscles. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31201990&form=6&db=m A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31205515&form=6&db=m c-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31205858&form=6&db=m Propofol Suppresses LPS-Induced Inflammation in Amnion Cells via Inhibition of NF-?B Activation. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31207405&form=6&db=m Oxymatrine exhibits anti-neuroinflammatory effects on A?1-42-induced primary microglia cells by inhibiting NF-?B and MAPK signaling pathways. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31210111&form=6&db=m Application of a Validated QSTR Model for Repurposing COX-2 Inhibitor Coumarin Derivatives as Potential Antitumor Agents. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31211952&form=6&db=m Caffeoyloxy-5,6-dihydro-4-methyl-(2H)-pyran-2-one isolated from the leaves of Olinia usambarensis attenuates LPS-induced inflammatory mediators by inactivating AP-1 and NF-?B. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31213577&form=6&db=m Higenamine inhibits IL-1?-induced inflammation in human nucleus pulposus cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31213849&form=6&db=m Knockdown of cyclooxygenase-2 leads to growth inhibition and cell cycle arrest in hepatocellular carcinoma cells. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31221042&form=6&db=m Nonocular Melanocytic Neoplasia in Cats: Characterization and Proposal of a Histologic Classification Scheme to More Accurately Predict Clinical Outcome. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31222746&form=6&db=m Silencing of PTGS2 exerts promoting effects on angiogenesis endothelial progenitor cells in mice with ischemic stroke via repression of the NF-?B signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31223291&form=6&db=m Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31226691&form=6&db=m BIO alleviates inflammation through inhibition of GSK-3? in a rat model of intracerebral hemorrhage. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31229286&form=6&db=m Potential for a localized immune response by the ruminal epithelium in nonpregnant heifers following a short-term subacute ruminal acidosis challenge. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31231223&form=6&db=m Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31233340&form=6&db=m QSAR Classification-Based Virtual Screening Followed by Molecular Docking Identification of Potential COX-2 Inhibitors in a Natural Product Library. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31234130&form=6&db=m A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-?B, COX-2 and iNOS signaling. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31238499&form=6&db=m Antiproliferative Activity of Pt(IV) Conjugates Containing the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Ketoprofen and Naproxen †. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31240210&form=6&db=m Galangin Suppresses Renal Inflammation via the Inhibition of NF-?B, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31241043&form=6&db=m Diosmin suppresses the proinflammatory mediators in lipopolysaccharide-induced RAW264.7 macrophages via NF-?B and MAPKs signal pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31242213&form=6&db=m Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31244287&form=6&db=m Over-Expression of Cyclooxygenase-2 in Colorectal Cancer Patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31248140&form=6&db=m Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31252679&form=6&db=m Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31257288&form=6&db=m Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31257800&form=6&db=m [Effects of apple polyphenols on monocrotaline-induced pulmonary vascular remodeling in rats and its mechanism]. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31262159&form=6&db=m Proinflammatory effects of photoactivated methylene blue on rat model of Walker 256 carcinosarcoma. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31270288&form=6&db=m Protective Effects of Timosaponin AIII against UVB-Radiation Induced Inflammation and DNA Injury in Human Epidermal Keratinocytes. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31272909&form=6&db=m Vitamin D, linoleic acid, arachidonic acid and COX-2 in colorectal cancer patients in relation to disease stage, tumour localisation and disease progression. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31278647&form=6&db=m Soybean isoflavone ameliorates cognitive impairment, neuroinflammation, and amyloid ? accumulation in a rat model of Alzheimer's disease. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31282597&form=6&db=m MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31289003&form=6&db=m Expression of PCNA, Ki-67 and COX-2 in breast cancer based on DCE-MRI image information. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31290458&form=6&db=m Atsttrin reduces lipopolysaccharide-induced neuroinflammation by inhibiting the nuclear factor kappa B signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291992&form=6&db=m COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31301770&form=6&db=m Dexmedetomidine inhibits apoptosis and expression of COX-2 induced by lipopolysaccharide in primary human alveolar epithelial type 2?cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31308795&form=6&db=m Analgesic Effect of Toll-like Receptor 4 Antagonistic Peptide 2 on Mechanical Allodynia Induced with Spinal Nerve Ligation in Rats. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31310338&form=6&db=m A perspective on risk factors for esophageal adenocarcinoma: emphasis on Helicobacter pylori infection. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31310911&form=6&db=m Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-?B signaling pathways. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31325027&form=6&db=m Selenomethionine relieves inflammation in the chicken trachea caused by LPS though inhibiting the NF-?B pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31326176&form=6&db=m Anti-inflammatory activities of Maillard reaction products from whey protein isolate fermented by Lactobacillus gasseri 4M13 in lipopolysaccharide-stimulated RAW264.7 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31334675&form=6&db=m The prognostic roles of cyclooxygenase-2 for patients with basal cell carcinoma. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31336132&form=6&db=m Thyroid hormone-induced expression of inflammatory cytokines interfere with resveratrol-induced anti-proliferation of oral cancer cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31337260&form=6&db=m Berberine reduces neuroglia activation and inflammation in streptozotocin-induced diabetic mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31340682&form=6&db=m Biomarkers associated with idiopathic frozen shoulder: a systematic review. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31347609&form=6&db=m Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31349553&form=6&db=m Development of An Oral Treatment with the PPAR-?-Acting Cannabinoid VCE-003.2 Against the Inflammation-Driven Neuronal Deterioration in Experimental Parkinson's Disease. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350224&form=6&db=m Cyclooxygenase and CD147 expression in oral squamous cell carcinoma patient samples and cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31351366&form=6&db=m Farrerol protects dopaminergic neurons in a rat model of lipopolysaccharide-induced Parkinson's disease by suppressing the activation of the AKT and NF-?B signaling pathways. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31359010&form=6&db=m Troxerutin suppresses the inflammatory response in advanced glycation end-product-administered chondrocytes and attenuates mouse osteoarthritis development. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366361&form=6&db=m Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31379572&form=6&db=m Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31382305&form=6&db=m Involvement of Platelets in Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31383251&form=6&db=m An alpha-lipoic acid-decursinol hybrid compound attenuates lipopolysaccharide-mediated inflammation in BV2 and RAW264.7 cells. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31383359&form=6&db=m Regulation of aquaporin 4 expression by lipoxin A4 in astrocytes stimulated by lipopolysaccharide. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31387329&form=6&db=m Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, Inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31392548&form=6&db=m Correction to: Inhibitory effects of tea polyphenols by targeting cyclooxygenase-2 through regulation of nuclear factor kappa B, Akt and p53 in rat mammary tumors. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31392591&form=6&db=m Cyclooxygenase-2 Induced the ?-Amyloid Protein Deposition and Neuronal Apoptosis Via Upregulating the Synthesis of Prostaglandin E2 and 15-Deoxy-?12,14-prostaglandin J2. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31393712&form=6&db=m 7-Deoxy-trans-dihydronarciclasine Isolated from Lycoris chejuensis Inhibits Neuroinflammation in Experimental Models. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31400342&form=6&db=m Modulation of COX-2, INF-?, glutamatergic and opioid systems contributes to antinociceptive, anti-inflammatory and anti-hyperalgesic effects of bis(3-amino-2-pyridine) diselenide. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31405112&form=6&db=m The Cyclooxigenase-2 Inhibitor Parecoxib Prevents Epidermal Dysplasia in HPV16-Transgenic Mice: Efficacy and Safety Observations. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31411316&form=6&db=m Ginsenoside Rd inhibits IL-1?-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31412307&form=6&db=m Dual CTLA-4 and PD-L1 Blockade Inhibits Tumor Growth and Liver Metastasis in a Highly Aggressive Orthotopic Mouse Model of Colon Cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31412319&form=6&db=m Effects of inflammatory responses, apoptosis, and STAT3/NF-?B- and Nrf2-mediated oxidative stress on benign prostatic hyperplasia induced by a high-fat diet. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31419499&form=6&db=m Viburnum pichinchense methanol extract exerts anti-inflammatory effects via targeting the NF-?B and caspase-11 non-canonical inflammasome pathways in macrophages. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423564&form=6&db=m Nitric oxide and hepatocellular cancer. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423645&form=6&db=m Deoxynivalenol induces oxidative stress, inflammatory response and apoptosis in bovine mammary epithelial cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31423851&form=6&db=m Altered mRNA Expression of Genes Involved in Endocannabinoid Signalling in Squamous Cell Carcinoma of the Oral Tongue. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31427974&form=6&db=m Luteoloside Inhibits IL-1?-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31430921&form=6&db=m Protective Effects Induced by Two Polyphenolic Liquid Complexes from Olive (Olea europaea, mainly Cultivar Coratina) Pressing Juice in Rat Isolated Tissues Challenged with LPS. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31431500&form=6&db=m Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31443756&form=6&db=m Can intravesical application of paracetamol benefit the chemotherapy treatment of bladder cancer? causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31453087&form=6&db=m Anti-inflammatory and analgesic potential of Tamarindus indica Linn. (Fabaceae): a narrative review. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31469327&form=6&db=m New pyrimidines and triazolopyrimidines as antiproliferative and antioxidants with cyclooxygenase-1/2 inhibitory potential. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31473273&form=6&db=m EBV down-regulates COX-2 expression via TRAF2 and ERK signal pathway in EBV-associated gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31473897&form=6&db=m The Activation of Heat-Shock Protein After Copper(II) and/or Arsenic(III)-Induced Imbalance of Homeostasis, Inflammatory Response in Chicken Rectum. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31473900&form=6&db=m Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in Caco-2 Cell Monolayers. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31474681&form=6&db=m Oral Supplementation of Tocotrienol-Rich Fraction Alleviates Severity of Ulcerative Colitis in Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31480608&form=6&db=m Synthesis and Different Effects of Biotinylated PAMAM G3 Dendrimer Substituted with Nimesulide in Human Normal Fibroblasts and Squamous Carcinoma Cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31486495&form=6&db=m Clinical significance of circulating tumor cells and their expression of cyclooxygenase-2 in patients with nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31491433&form=6&db=m Melatonin protects against lipopolysaccharide-induced epididymitis in sheep epididymal epithelial cells in vitro. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31494294&form=6&db=m A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31497247&form=6&db=m Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31497826&form=6&db=m Urolithin A targets the PI3K/Akt/NF-?B pathways and prevents IL-1?-induced inflammatory response in human osteoarthritis: in vitro and in vivo studies. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31501647&form=6&db=m Potential antitumor activity of nonsteroidal anti-inflammatory drugs against Ehrlich ascites carcinoma in experimental animals. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31505123&form=6&db=m Modulation of oxidative/nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia/reperfusion: The role of mTOR. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31506784&form=6&db=m Beta-ionone-inhibited proliferation of breast cancer cells by inhibited COX-2 activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31507153&form=6&db=m Expressions of cyclooxygenase 2 in gastrointestinal stromal tumors. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31523430&form=6&db=m The therapeutic activity of curcumin through its anti-cancer potential on oral squamous cell carcinoma: A study on Sprague Dawley rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31526853&form=6&db=m Pan-cancer analysis of the metabolic reaction network. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31528165&form=6&db=m Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31533599&form=6&db=m Variances in the level of of COX-2 and iNOS in different grades of endometrial cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31540047&form=6&db=m Dietary Polyacetylenic Oxylipins Falcarinol and Falcarindiol Prevent Inflammation and Colorectal Neoplastic Transformation: A Mechanistic and Dose-Response Study in A Rat Model. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31541501&form=6&db=m Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate ketamine-induced cystitis by modulating neuroreceptors, inflammatory mediators, and fibrogenesis in a rat model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31554962&form=6&db=m Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/I?B/NF-?B/BACE1 signaling pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31556594&form=6&db=m A New Formyl Peptide Receptor-1 Antagonist Conjugated Fullerene Nanoparticle for Targeted Treatment of Degenerative Disc Diseases. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31557616&form=6&db=m Novel sampling procedure to characterize bovine subclinical endometritis by uterine secretions and tissue. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31557846&form=6&db=m Red-Osier Dogwood Extracts Prevent Inflammatory Responses in Caco-2 Cells and a Caco-2 BBe1/EA.hy926 Cell Co-Culture Model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31571864&form=6&db=m A comparative study: the prospective influence of nanovectors in leveraging the chemopreventive potential of COX-2 inhibitors against skin cancer. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31572805&form=6&db=m Dihydromyricetin Attenuates Inflammation through TLR4/NF-kappaB Pathway. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31586705&form=6&db=m Oleanolic acid oxime derivatives and their conjugates with aspirin modulate the NF-?B-mediated transcription in HepG2 hepatoma cells. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31594701&form=6&db=m NSAID therapy for PIK3CA-Altered colorectal, breast, and head and neck cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31598112&form=6&db=m Radiosynthesis and Preclinical Evaluation of 11C-VA426, a Cyclooxygenase-2 Selective Ligand. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31601783&form=6&db=m Response gene to complement 32 expression in macrophages augments paracrine stimulation-mediated colon cancer progression. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31610501&form=6&db=m Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31611882&form=6&db=m Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31614548&form=6&db=m Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31614846&form=6&db=m Salix tetrasperma Roxb. Extract Alleviates Neuropathic Pain in Rats via Modulation of the NF-?B/TNF-?/NOX/iNOS Pathway. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31615816&form=6&db=m Tumor Immune Microenvironment and Chemosensitivity Signature for Predicting Response to Chemotherapy in Gastric Cancer. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31616306&form=6&db=m Desmethylbellidifolin From Gentianella acuta Ameliorate TNBS-Induced Ulcerative Colitis Through Antispasmodic Effect and Anti-Inflammation. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31617778&form=6&db=m Chemopreventive efficacy of juniper berry oil (Juniperus communis L.) on azoxymethane-induced colon carcinogenesis in rat. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31620100&form=6&db=m Chitooligosaccharides Prevents the Development of Colitis-Associated Colorectal Cancer by Modulating the Intestinal Microbiota and Mycobiota. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31623608&form=6&db=m pH and redox dual-responsive nanoparticles based on disulfide-containing poly(?-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 2,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31626054&form=6&db=m Aerobic Training and Green Tea Extract Protect against N-methyl-N-nitrosourea-induced Prostate Cancer. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31627218&form=6&db=m Prophylactic Effect of Opuntia ficus indica Fruit Peel Extract against Irradiation-Induced Colon Injury in Rats. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31627460&form=6&db=m Anti-Inflammatory Activity of Some Characteristic Constituents from the Vine Stems of Spatholobus suberectus. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31632242&form=6&db=m Targeting Inflammatory Processes Mediated by TRPVI and TNF-? for Treating Noise-Induced Hearing Loss. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31632572&form=6&db=m Tumor-associated macrophages induce invasion and poor prognosis in human gastric cancer in a cyclooxygenase-2/MMP9-dependent manner. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31641036&form=6&db=m Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31652609&form=6&db=m Synthesis and Cyclooxygenase Inhibition of Sulfonamide-Substituted (Dihydro)Pyrrolo[3,2,1-hi]indoles and Their Potential Prodrugs. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31654581&form=6&db=m 4-nitrophenol exposure in T24 human bladder cancer cells promotes proliferation, motilities, and epithelial-to-mesenchymal transition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31655104&form=6&db=m Design and construction of COX-2 specific fluorescent probes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31655429&form=6&db=m Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666999&form=6&db=m Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31669519&form=6&db=m Galectin-1 attenuates neurodegeneration in Parkinson's disease model by modulating microglial MAPK/I?B/NF?B axis through its carbohydrate-recognition domain. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31675116&form=6&db=m Immunohistochemical detectability of cyclooxygenase-2 expression in cells of human melanocytic skin lesions: A methodological review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31679460&form=6&db=m RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31680279&form=6&db=m Stevia residue extract alone and combination with allopurinol attenuate hyperuricemia in fructose-PO-induced hyperuricemic mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31683199&form=6&db=m A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31686890&form=6&db=m Impact of polyphenols in phagocyte functions. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31688905&form=6&db=m Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31692172&form=6&db=m Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31696069&form=6&db=m The role of immunohistochemistry expression of COX-2 in differentiating pigmented benign and malignant skin neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31696959&form=6&db=m 1,2,4-Triazole-conjugated 1,3,4-thiadiazole hybrid scaffolds: A potent ameliorant of carrageenan-induced inflammation by lessening proinflammatory mediators. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31712149&form=6&db=m Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31718011&form=6&db=m Anti-Inflammatory and Anti-Hyperuricemic Functions of Two Synthetic Hybrid Drugs with Dual Biological Active Sites. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31723665&form=6&db=m Anti-inflammatory effect of remifentanil in lipopolysaccharide-stimulated amniotic epithelial cells. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31724835&form=6&db=m Selective inhibition of cyclooxygenase-2 protects porcine aortic endothelial cells from human antibody-mediated complement-dependent cytotoxicity. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31726219&form=6&db=m A journey of celecoxib from pain to cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31732449&form=6&db=m LXW7 attenuates inflammation via suppressing Akt/nuclear factor kappa B and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated BV2 microglial cells. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31732563&form=6&db=m Inhibition of CD44 induces apoptosis, inflammation, and matrix metalloproteinase expression in tendinopathy. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31739009&form=6&db=m A glucogalactomanan polysaccharide isolated from Agaricus bisporus causes an inflammatory response via the ERK/MAPK and I?B/NF?B pathways in macrophages. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31744147&form=6&db=m Phytosterols Suppress Phagocytosis and Inhibit Inflammatory Mediators via ERK Pathway on LPS-Triggered Inflammatory Responses in RAW264.7 Macrophages and the Correlation with Their Structure. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31745806&form=6&db=m The anti-inflammatory influence of Cinnamomum burmannii against multi-walled carbon nanotube-induced liver injury in rats. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31749431&form=6&db=m In Silico Screening for Anti-Inflammatory Bioactive Molecules from Ayurvedic Decoction, Balaguluchyadi Kashayam. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31752555&form=6&db=m Bromelain Enhances the Anti-tumor Effects of Cisplatin on 4T1 Breast Tumor Model In Vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31756450&form=6&db=m Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31759380&form=6&db=m Association between Cyclooxygenase-2 and Indoleamine 2,3-Dioxygenase Expression in Breast Cancer Patients from Pakistan. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31760092&form=6&db=m Trans-4,4'-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31761163&form=6&db=m Discovering pH triggered charge rebound surface modulated topical nanotherapy against aggressive skin papilloma. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31769535&form=6&db=m Pulsed Electromagnetic Field Modulates Tendon Cells Response in IL-1?-Conditioned Environment. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775672&form=6&db=m Detection of carcinogen-induced bladder cancer by fluorocoxib A. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31776889&form=6&db=m Investigation of Modulatory Effect of Pinolenic Acid (PNA) on Inflammatory Responses in Human THP-1 Macrophage-Like Cell and Mouse Models. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31780924&form=6&db=m Protective Effect of Ginkgolic Acid in Attenuating LDL Induced Inflammation Human Peripheral Blood Mononuclear Cells via Altering the NF-?B Signaling Pathway. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31783895&form=6&db=m Cross-talk between SIM2s and NF?B regulates cyclooxygenase 2 expression in breast cancer. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31786945&form=6&db=m Anti-Apoptotic and Anti-Inflammatory Activities of Edible Fresh Water Algae Prasiola japonica in UVB-Irradiated Skin Keratinocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31786947&form=6&db=m Ginsenoside Rb1, A Major Saponin from Panax ginseng, Exerts Protective Effects Against Acetaminophen-Induced Hepatotoxicity in Mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31787867&form=6&db=m Ginsenoside Rg1 Exerts Anti-inflammatory Effects via G Protein-Coupled Estrogen Receptor in Lipopolysaccharide-Induced Microglia Activation. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31788101&form=6&db=m Growth inhibitory effects of PC-NSAIDs on human breast cancer subtypes in cell culture. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31789064&form=6&db=m Galectin-1 exhibits a protective effect against hepatotoxicity induced by dextran sulfate sodium in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31791289&form=6&db=m PPAR? ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31791318&form=6&db=m Water-separated part of Chloranthus serratus alleviates lipopolysaccharide- induced RAW264.7 cell injury mainly by regulating the MAPK and Nrf2/HO-1 inflammatory pathways. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31792484&form=6&db=m [Expression of CD44v6 and COX-2 in pleomorphic adenomas and carcinomas of parotid gland]. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31801720&form=6&db=m [Bioinformatic analysis of direct protein targets of aspirin against human breast cancer proliferation]. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31804169&form=6&db=m Nickel and Oxidative stress: Cell Signaling Mechanisms and Protective Role of Vitamin C. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31814838&form=6&db=m Network Pharmacology of Yougui Pill Combined with Buzhong Yiqi Decoction for the Treatment of Sexual Dysfunction. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31816246&form=6&db=m Radiosynthesis and Biological Evaluation of [18F]Triacoxib: A New Radiotracer for PET Imaging of COX-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31817701&form=6&db=m Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-?B Pathway. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31817719&form=6&db=m ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31822119&form=6&db=m Cyclooxygenase 2 Promotes Proliferation and Invasion in Ovarian Cancer Cells via the PGE2/NF-?B Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31825424&form=6&db=m Microalgae aqueous extracts exert intestinal protective effects in Caco-2 cells and dextran sodium sulphate-induced mouse colitis. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31825758&form=6&db=m Effect of Tempol, a Membrane-Permeable Free Radical Scavenger, on In Vitro Model of Eye Inflammation on Rabbit Corneal Cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31831632&form=6&db=m Aggressive Mammary Cancers Lacking Lymphocytic Infiltration Arise in Irradiated Mice and Can Be Prevented by Dietary Intervention. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31835924&form=6&db=m Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of I?B-?/NF-?B and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31844085&form=6&db=m C-phycocyanin: a natural product with radiosensitizing property for enhancement of colon cancer radiation therapy efficacy through inhibition of COX-2 expression. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31845157&form=6&db=m Synthesis and biological evaluation of RGD conjugated with Ketoprofen/Naproxen and radiolabeled with [99mTc] via N4(GGAG) for ?V?3 integrin-targeted drug delivery. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31846957&form=6&db=m Cyclooxygenase-2 Gene Polymorphisms -765G>C and -1195A>G and Mycosis Fungoides Risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31852261&form=6&db=m Wound healing activity of neferine in experimental diabetic rats through the inhibition of inflammatory cytokines and nrf-2 pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31854058&form=6&db=m An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31858402&form=6&db=m Effects of Excess Manganese on the Oxidative Status, and the Expression of Inflammatory Factors and Heat Shock Proteins in Cock Kidneys. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31859282&form=6&db=m Combination of Pan-HDAC Inhibitor and COX-2 Inhibitor Produces Synergistic Anticancer Effects in Human Salivary Adenoid Cystic Cancer Cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31860812&form=6&db=m Disruption of P2X4 purinoceptor and suppression of the inflammation associated with cerebral aneurysm formation. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31867739&form=6&db=m 7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31867776&form=6&db=m High COX-2 expression in cancer-associated fibiroblasts contributes to poor survival and promotes migration and invasiveness in nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31868102&form=6&db=m Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31874252&form=6&db=m Growth hormone-releasing hormone (GHRH) deficiency promotes inflammation-associated carcinogenesis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31876249&form=6&db=m Renal interstitial cell tumor in a dog: clinicopathologic, imaging, and histologic features. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31878864&form=6&db=m Pro- and anti-inflammatory cytokine expression levels in macrophages; An approach to develop indazolpyridin-methanones as novel inflammation medication. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31882466&form=6&db=m Radical-scavenging and Pro-/anti-inflammatory Activity of Tetracycline and Related Phenolic Compounds With or Without Visible Light Irradiation. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31885062&form=6&db=m Ellagic acid ameliorates lung damage in rats via modulating antioxidant activities, inhibitory effects on inflammatory mediators and apoptosis-inducing activities. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31886219&form=6&db=m In Vivo, Proteomic, and In Silico Investigation of Sapodilla for Therapeutic Potential in Gastrointestinal Disorders. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31886579&form=6&db=m Synthesis and anti-inflammatory effects of novel emodin derivatives bearing azole moieties. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31887490&form=6&db=m Organochlorine pesticides induce inflammation, ROS production, and DNA damage in human epithelial ovary cells: An in vitro study. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31894359&form=6&db=m Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31896516&form=6&db=m Neutralizing tumor-promoting inflammation with polypeptide-dexamethasone conjugate for microenvironment modulation and colorectal cancer therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31905343&form=6&db=m Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-?B to the COX-2 promoter. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31908572&form=6&db=m Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31914614&form=6&db=m Plumericin prevents intestinal inflammation and oxidative stress in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31916291&form=6&db=m Ablation of PKM2 ameliorated ER stress-induced apoptosis and associated inflammation response in IL-1?-treated chondrocytes via blocking Rspo2-mediated Wnt/?-catenin signaling. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31918672&form=6&db=m Aspirin decreases hepatocellular carcinoma risk in hepatitis C virus carriers: a nationwide cohort study. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920649&form=6&db=m Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31926054&form=6&db=m Effect of citronellol on NF-kB inflammatory signaling molecules in chemical carcinogen-induced mammary cancer in the rat model. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31926437&form=6&db=m Association between serum concentrations of perfluoroalkyl substances (PFAS) and expression of serum microRNAs in a cohort highly exposed to PFAS from drinking water. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31927051&form=6&db=m Nifedipine inhibits oxidative stress and ameliorates osteoarthritis by activating the nuclear factor erythroid-2-related factor 2 pathway. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31929812&form=6&db=m Neuroprotective Effect of Optimized Yinxieling Formula in 6-OHDA-Induced Chronic Model of Parkinson's Disease through the Inflammation Pathway. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934287&form=6&db=m BPTF cooperates with p50 NF-?B to promote COX-2 expression and tumor cell growth in lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934887&form=6&db=m Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31935470&form=6&db=m In vivo preclinical evaluation of the new 68Ga-labeled beta-cyclodextrin in prostaglandin E2 (PGE2) positive tumor model using positron emission tomography. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31935983&form=6&db=m Inhibitory Effects of Myricetin on Lipopolysaccharide-Induced Neuroinflammation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31936383&form=6&db=m Benzimidazole Containing Acetamide Derivatives Attenuate Neuroinflammation and Oxidative Stress in Ethanol-Induced Neurodegeneration. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31942449&form=6&db=m Effects of remifentanil preconditioning on factors related to uterine contraction in WISH cells. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31957490&form=6&db=m Effect of heat-killed Enterococcus faecalis EF-2001 on ethanol-induced acute gastric injury in mice: Protective effect of EF-2001 on acute gastric ulcer. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31970641&form=6&db=m Ammonia inhalation-induced inflammation and structural impairment in the bursa of fabricius and thymus of broilers through NF-?B signaling pathway. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31970686&form=6&db=m Cyclooxygenase-2 expression as a prognostic factor in pediatric classical Hodgkin lymphoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31981721&form=6&db=m JWH133 inhibits MPP+-induced inflammatory response and iron influx in astrocytes. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31988007&form=6&db=m Does tumour necrosis factor alpha-induced cyclooxygenase-2 expression lead to spontaneous abortion in Chlamydia trachomatis-infected women. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31999977&form=6&db=m Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-?B and STAT3 pathways. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32002341&form=6&db=m Synergistic effect of ascorbic acid and taurine in the treatment of a spinal cord injury-induced model in rats. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32002856&form=6&db=m A novel isoquinoline derivative exhibits anti-inflammatory properties and improves the outcomes of endotoxemia. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32004752&form=6&db=m The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007723&form=6&db=m Anti-inflammatory effects of an optimized PPAR-? agonist via NF-?B pathway inhibition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32008775&form=6&db=m A synbiotic combination of Lactobacillus gasseri 505 and Cudrania tricuspidata leaf extract prevents hepatic toxicity induced by colorectal cancer in mice. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32009962&form=6&db=m Gaudichaudione H Inhibits Inflammatory Responses in Macrophages and Dextran Sodium Sulfate-Induced Colitis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32010304&form=6&db=m Antioxidant, anti-inflammatory and anti-fibrotic effects of Boswellia serrate gum resin in CCl4-induced hepatotoxicity. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32016638&form=6&db=m Simvastatin Improves Behavioral Disorders and Hippocampal Inflammatory Reaction by NMDA-Mediated Anti-inflammatory Function in MPTP-Treated Mice. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32020054&form=6&db=m Postpartum breast cancer progression is driven by semaphorin 7a-mediated invasion and survival. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32022330&form=6&db=m Protective effect of rutin on mercuric chloride-induced reproductive damage in male rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32027888&form=6&db=m Gabapentin attenuates intestinal inflammation: Role of PPAR-gamma receptor. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32030565&form=6&db=m The beneficial effect of cold atmospheric plasma on parameters of molecules and cell function involved in wound healing in human osteoblast-like cells in vitro. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32033338&form=6&db=m Physalis angulata Calyces Modulate Macrophage Polarization and Alleviate Chemically Induced Intestinal Inflammation in Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32058211&form=6&db=m The protective effect of Ellagic acid (EA) in osteoarthritis: An in vitro and in vivo study. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32058311&form=6&db=m Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32059355&form=6&db=m Protective Effect of Cicer arietinum L. (Chickpea) Ethanol Extract in the Dextran Sulfate Sodium-Induced Mouse Model of Ulcerative Colitis. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32059406&form=6&db=m Enhancement of the Anti-Inflammatory Effect of Mustard Kimchi on RAW 264.7 Macrophages by the Lactobacillus plantarum Fermentation-Mediated Generation of Phenolic Compound Derivatives. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32070920&form=6&db=m S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32073014&form=6&db=m Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-?B signaling pathway in vivo and in vitro. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32077170&form=6&db=m The G protein-coupled oestrogen receptor, GPER1, mediates direct anti-inflammatory effects of oestrogens in human cholinergic neurones from the nucleus basalis of Meynert. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32079242&form=6&db=m Fucoxanthinol from the Diatom Nitzschia Laevis Ameliorates Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV-2 Microglia. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32085388&form=6&db=m Coixol Suppresses NF-?B, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32085795&form=6&db=m Cytoplasmic PPAR? is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32090454&form=6&db=m Arctigenin prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-?B axis: In vitro and in vivo studies. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32104177&form=6&db=m Antitumor Activity of Ficus deltoidea Extract on Oral Cancer: An In Vivo Study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32106742&form=6&db=m Heat-treated human platelet pellet lysate modulates microglia activation, favors wound healing and promotes neuronal differentiation in vitro. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32138539&form=6&db=m Versican expression level in cumulus cells is associated with human oocyte developmental competence. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32138838&form=6&db=m Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32149087&form=6&db=m Polydeoxyribonucleotide Exerts Therapeutic Effect by Increasing VEGF and Inhibiting Inflammatory Cytokines in Ischemic Colitis Rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32151873&form=6&db=m Nitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activities. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32157241&form=6&db=m An integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32159191&form=6&db=m The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32161122&form=6&db=m Integrative analysis of multi-omics data identified EGFR and PTGS2 as key nodes in a gene regulatory network related to immune phenotypes in head and neck cancer. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32161544&form=6&db=m Scutellarin Attenuates the IL-1?-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32165203&form=6&db=m Effect of beta- and alpha-glucans on immune modulating factors expression in enterocyte-like Caco-2 and goblet-like LS 174T cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32166561&form=6&db=m The Effects of Selenium in Acrylamide-Induced Nephrotoxicity in Rats: Roles of Oxidative Stress, Inflammation, Apoptosis, and DNA Damage. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32168749&form=6&db=m Evaluation of Glycosylated PTGS2 in Colorectal Cancer for NSAIDS-Based Adjuvant Therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171274&form=6&db=m Cyclooxygenase enzyme and PGE2 expression in patients with functional and non-functional pituitary adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32173393&form=6&db=m Chemopreventive activity of Tualang honey against oral squamous cell carcinoma-in vivo. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32174282&form=6&db=m Prospects of NSAIDs administration as double-edged agents against endometrial cancer and pathological species of the uterine microbiome. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32183436&form=6&db=m Inhibitory Effects of Aucklandia lappa Decne. Extract on Inflammatory and Oxidative Responses in LPS-Treated Macrophages. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32185157&form=6&db=m Anti-inflammatory Limonoids From Cortex Dictamni. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32185948&form=6&db=m Modified Shenlingbaizhu decoction reduces intestinal adenoma formation in adenomatous polyposis coli multiple intestinal neoplasia mice by suppression of hypoxia-inducible factor 1?-induced CD4+CD25+forkhead box P3 regulatory T cells. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32186111&form=6&db=m Young Yum pill inhibits inflammatory mediators and nuclear factor-kappa B signaling in lipopolysaccharide-stimulated RAW 264.7 macrophages. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32186945&form=6&db=m Dietary Mixed Cereal Grains Ameliorate the Azoxymethane and Dextran Sodium Sulfate-Induced Colonic Carcinogenesis in C57BL/6J Mice. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32187984&form=6&db=m Anti-Inflammatory and Anti-Oxidative Effects of luteolin-7-O-glucuronide in LPS-Stimulated Murine Macrophages through TAK1 Inhibition and Nrf2 Activation. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32204312&form=6&db=m Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32209602&form=6&db=m Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32214798&form=6&db=m miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32216542&form=6&db=m Parecoxib exhibits anti-inflammatory and neuroprotective effects in a rat model of transient global cerebral ischemia. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32222576&form=6&db=m The flavonoid-enriched extract from the root of Smilax china L. inhibits inflammatory responses via the TLR-4-mediated signaling pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32223342&form=6&db=m Vitex doniana Leaves Extract Ameliorates Alterations Associated with 7, 12-Dimethyl Benz[a]Anthracene-Induced Mammary Damage in Female Wistar Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32224280&form=6&db=m ROS induced by spring viraemia of carp virus activate the inflammatory response via the MAPK/AP-1 and PI3K signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32227417&form=6&db=m Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32235618&form=6&db=m FlexPro MD®, a Combination of Krill Oil, Astaxanthin and Hyaluronic Acid, Reduces Pain Behavior and Inhibits Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32235869&form=6&db=m New insights into the functions of Cox-2 in skin and esophageal malignancies. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32236281&form=6&db=m Naproxen platinum(iv) hybrids inhibiting cycloxygenases and matrix metalloproteinases and causing DNA damage: synthesis and biological evaluation as antitumor agents in vitro and in vivo. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32238697&form=6&db=m Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor ?/? abrogation. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32248223&form=6&db=m Ultrasound Stimulation Suppresses LPS-Induced Proinflammatory Responses by Regulating NF-?B and CREB Activation in Microglial Cells. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32250024&form=6&db=m Lonicera caerulea L. Polyphenols Alleviate Oxidative Stress-Induced Intestinal Environment Imbalance and Lipopolysaccharide-Induced Liver Injury in HFD-Fed Rats by Regulating the Nrf2/HO-1/NQO1 and MAPK Pathways. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32250487&form=6&db=m The preventive effect of ellagic acid on brain damage in rats via regulating of Nrf-2, NF-kB and apoptotic pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32253841&form=6&db=m Cyclooxygenase-2 promotes ovarian cancer cell migration and cisplatin resistance via regulating epithelial mesenchymal transition. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32256985&form=6&db=m Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32258812&form=6&db=m Cyclooxygenase-2 as a Biomarker with Diagnostic, Therapeutic, Prognostic, and Predictive Relevance in Small Animal Oncology. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32259630&form=6&db=m circRNA_0084043 contributes to the progression of diabetic retinopathy via sponging miR-140-3p and inducing TGFA gene expression in retinal pigment epithelial cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32264335&form=6&db=m pH-Responsive nanoparticles based on ibuprofen prodrug as drug carriers for inhibition of primary tumor growth and metastasis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32265160&form=6&db=m Chronic unpredictable stress-induced reproductive deficits were prevented by probiotics. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32266177&form=6&db=m Effects of Genetic and Pharmacologic Inhibition of COX-2 on Colitis-associated Carcinogenesis in Mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32269737&form=6&db=m Selective EP2 and Cox-2 inhibition suppresses cell migration by reversing epithelial-to-mesenchymal transition and Cox-2 overexpression and E-cadherin downregulation are implicated in neck metastasis of hypopharyngeal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32273947&form=6&db=m Meloxicam, a Selective COX-2 Inhibitor, Mediates Hypoxia-Inducible Factor- (HIF-) 1? Signaling in Hepatocellular Carcinoma. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32277667&form=6&db=m Relationships of pain in pancreatic cancer patients with pathological stage and expressions of NF-?B and COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32278833&form=6&db=m MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32284763&form=6&db=m Cyclooxygenase-2 mediates gefitinib resistance in non-small cell lung cancer through the EGFR/PI3K/AKT axis. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32288789&form=6&db=m Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32290492&form=6&db=m Meroterpenoids from the Brown Alga Cystoseira usneoides as Potential Anti-Inflammatory and Lung Anticancer Agents. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32302031&form=6&db=m Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32311852&form=6&db=m Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32314719&form=6&db=m [Amentoflavone inhibits inflammation of mouse BV-2 microglia cells induced by lipopolysaccharide]. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32322056&form=6&db=m Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32323423&form=6&db=m Cyclooxygenase-2 expression is associated with infiltration of inflammatory cells in oral and skin canine melanomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32324309&form=6&db=m Astilbin ameliorates deoxynivalenol-induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC-J2). causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32325189&form=6&db=m Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - Effects that are susceptible to antidepressants. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32326385&form=6&db=m Anti-Inflammatory and Antioxidant Effects of Anthocyanins of Trifolium pratense (Red Clover) in Lipopolysaccharide-Stimulated RAW-267.4 Macrophages. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32326535&form=6&db=m Anti-Inflammatory Functions of Alverine via Targeting Src in the NF-?B Pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32330842&form=6&db=m Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-?B signaling. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32331475&form=6&db=m Glycomacropeptide Prevents Iron/Ascorbate-Induced Oxidative Stress, Inflammation and Insulin Sensitivity with an Impact on Lipoprotein Production in Intestinal Caco-2/15 Cells. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32335193&form=6&db=m USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-?B signaling pathway in mice. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32336005&form=6&db=m Prognostic significance of immunohistochemical markers and histological classification in malignant canine mammary tumours. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32338278&form=6&db=m Genetic polymorphisms as non-modifiable susceptibility factors to laryngeal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32346326&form=6&db=m Spiroindolone analogues bearing benzofuran moiety as a selective cyclooxygenase COX-1 with TNF-? and IL-6 inhibitors. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32347551&form=6&db=m Downregulation of XIST ameliorates acute kidney injury by sponging miR-142-5p and targeting PDCD4. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32356340&form=6&db=m Knockdown of NEAT1 exerts suppressive effects on diabetic retinopathy progression via inactivating TGF-?1 and VEGF signaling pathways. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32357521&form=6&db=m Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32363546&form=6&db=m COX-2-PGE2-EPs in gynecological cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32366045&form=6&db=m Limited Proteolysis of Cyclooxygenase-2 Enhances Cell Proliferation. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32368976&form=6&db=m Anticancer and Antimicrobial Activities of Naproxen and Naproxen Derivatives. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32370492&form=6&db=m Antagonism of GPR4 with NE 52-QQ57 and the Suppression of AGE-Induced Degradation of Type II Collagen in Human Chondrocytes. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32375072&form=6&db=m Chrysophyllum albidum fruit peel attenuates nociceptive pain and inflammatory response in rodents by inhibition of pro-inflammatory cytokines and COX-2 expression through suppression of NF-?B activation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32376713&form=6&db=m Detection of COX-2 in liquid biopsy in patients with breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32377166&form=6&db=m Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32380330&form=6&db=m NF-?B pathway took part in the development of apoptosis mediated by miR-15a and oxidative stress via mitochondrial pathway in ammonia-treated chicken splenic lymphocytes. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32381981&form=6&db=m [A Case of Pelvic Desmoid-Type Fibromatosis Treated by Radiation and Medication Therapies]. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32406443&form=6&db=m Akebia trifoliata pericarp extract ameliorates inflammation through NF-?B/MAPK signaling pathways and modifies gut microbiota. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32410997&form=6&db=m Cyclooxygenase 2-Regulated Genes an Alternative Avenue to the Development of New Therapeutic Drugs for Colorectal Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32411755&form=6&db=m Wogonoside inhibits inflammatory cytokine production in lipopolysaccharide-stimulated macrophage by suppressing the activation of the JNK/c-Jun signaling pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32414698&form=6&db=m Inflammatory myofibroblastic tumor in the head and neck-a neoplasm with both tumor features and inflammation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32426537&form=6&db=m Biochemical evaluation and molecular docking assessment of the anti-inflammatory potential of Phyllanthus nivosus leaf against ulcerative colitis. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32432251&form=6&db=m Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32433831&form=6&db=m Expression of cyclooxygenase-2 in imprint smears of endometrial carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32435431&form=6&db=m Evaluation of VEGF expression correlates with COX-2 expression in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32442574&form=6&db=m Structural characteristics and biological effects of exopolysaccharide produced by cyanobacterium Nostoc sp. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32448093&form=6&db=m Anti-inflammatory action of herbal medicine comprised of Scutellaria baicalensis and Chrysanthemum morifolium. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32453444&form=6&db=m Protective effect of Alpha-Linolenic acid on Lipopolysaccharide-Induced Orchitis in mice. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32453893&form=6&db=m S-allyl cysteine, an active ingredient of garlic, attenuates acute liver dysfunction induced by lipopolysaccharide/ d-galactosamine in mouse: Underlying mechanisms. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32454771&form=6&db=m Various In Vitro Bioactivities of Secondary Metabolites Isolated from the Sponge Hyrtios aff. Erectus from the Red Sea Coast of Egypt. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32460430&form=6&db=m Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32466476&form=6&db=m Post-Treatment of Synthetic Polyphenolic 1,3,4 Oxadiazole Compound A3, Attenuated Ischemic Stroke-Induced Neuroinflammation and Neurodegeneration. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32479014&form=6&db=m Nobiletin Inhibits Helicobacterium pylori Infection-Induced Gastric Carcinogenic Signaling by Blocking Inflammation, Apoptosis, and Mitogen-Activated Protein Kinase Events in Gastric Epithelial-1 Cells. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32479306&form=6&db=m Increased inflammatory biomarkers and changes in biological rhythms in bipolar disorder: A case-control study. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32482108&form=6&db=m Prophylactic effect of Biochanin A in lipopolysaccharide-stimulated BV2 microglial cells. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32484764&form=6&db=m Natural product inhibitors of cyclooxygenase (COX) enzyme: A Review on Current status and future perspectives. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485353&form=6&db=m Byakangelicin inhibits IL-1?-induced mouse chondrocyte inflammation in vitro and ameliorates murine osteoarthritis in vivo. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485532&form=6&db=m Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,3
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32493316&form=6&db=m Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32525764&form=6&db=m Elucidation of colon-protective efficacy of diosgenin in experimental TNBS-induced colitis: inhibition of NF-?B/IkB-? and Bax/Caspase-1 signaling pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540418&form=6&db=m Inhibition of NK1R attenuates LPS-induced microglial inflammation and consequent death of PC12 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540642&form=6&db=m Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32547404&form=6&db=m Eicosanoids in Cancer: Prostaglandin E2 Receptor 4 in Cancer Therapeutics and Immunotherapy. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32556929&form=6&db=m Polyphenols from Toona sinensiss Seeds Alleviate Neuroinflammation Induced by 6-Hydroxydopamine Through Suppressing p38 MAPK Signaling Pathway in a Rat Model of Parkinson's Disease. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32560430&form=6&db=m Effects of Gastrodin against Lead-Induced Brain Injury in Mice Associated with the Wnt/Nrf2 Pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32565941&form=6&db=m Pathological roles of c-Met in bladder cancer: Association with cyclooxygenase-2, heme oxygenase-1, vascular endothelial growth factor-A and programmed death ligand 1. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32569637&form=6&db=m Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32571310&form=6&db=m Gene expression of prostaglandin EP4 receptor in three canine carcinomas. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32577118&form=6&db=m Antiobesity and anti-inflammation effects of Hakka stir-fried tea of different storage years on high-fat diet-induced obese mice model via activating the AMPK/ACC/CPT1 pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32577932&form=6&db=m Examination of the effect of combined use of Er:YAG laser irradiation and mechanical force loading on bone metabolism using primary human gingival fibroblasts. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32581777&form=6&db=m Salvianolic Acid A Has Anti-Osteoarthritis Effect In Vitro and In Vivo. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32583504&form=6&db=m Effect of digital hypothermia on lamellar inflammatory signaling in the euglycemic hyperinsulinemic clamp laminitis model. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32599505&form=6&db=m Solid lipid nanoparticles-mediated enhanced antidepressant activity of duloxetine in lipopolysaccharide-induced depressive model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32599714&form=6&db=m Fucoidan Isolated from Saccharina japonica Inhibits LPS-Induced Inflammation in Macrophages via Blocking NF-?B, MAPK and JAK-STAT Pathways. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32613487&form=6&db=m Protective Effects of Chrysin Against Oxidative Stress and Inflammation Induced by Lead Acetate in Rat Kidneys: a Biochemical and Histopathological Approach. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32615181&form=6&db=m MicroRNAs in the anticancer effects of celecoxib: A systematic review. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32617108&form=6&db=m A Network Pharmacology Approach to Explore the Mechanisms of Shugan Jianpi Formula in Liver Fibrosis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32627543&form=6&db=m Picrorhizones A-H, Polyprenylated Benzoylphloroglucinols from the Stem Bark of Garcinia picrorhiza. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32630038&form=6&db=m Inhibition of UVB-Induced Inflammation by Laminaria japonica Extract via Regulation of nc886-PKR Pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32632914&form=6&db=m Radiosynthesis and evaluation of [18F]FMTP, a COX-2 PET ligand. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32642723&form=6&db=m Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32645833&form=6&db=m Loss of miR-101-3p Promotes Transmigration of Metastatic Breast Cancer Cells through the Brain Endothelium by Inducing COX-2/MMP1 Signaling. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32646396&form=6&db=m Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32650362&form=6&db=m Preventative Effect of Mebendazole against Malignancies in Neurofibromatosis 1. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32652081&form=6&db=m Toll-like receptor-9 (TLR-9) deficiency alleviates optic nerve injury (ONI) by inhibiting inflammatory response in vivo and in vitro. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655834&form=6&db=m miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32659677&form=6&db=m Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32662567&form=6&db=m ?-Elemene inhibits 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced skin tumorigenesis through suppression of NF-?B-associated signaling events in the mouse skin model. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32668967&form=6&db=m [Formula: see text], a Rare Protopanaxatriol-Type Ginsenoside Fraction from Black Ginseng, Suppresses Inflammatory Gene iNOS via the Iinhibition of p-STAT-1 and NF-[Formula: see text]B. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32670864&form=6&db=m Administration of Metabiotics Extracted From Probiotic Lactobacillus rhamnosus MD 14 Inhibit Experimental Colorectal Carcinogenesis by Targeting Wnt/?-Catenin Pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32673849&form=6&db=m Anti-inflammatory effect of selenium on lead-induced testicular inflammation by inhibiting NLRP3 inflammasome activation in chickens. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32685208&form=6&db=m The Effect of Rice Bran Extract on Arterial Blood Pressure, Hepatic Steatosis, and Inflammation in Mice Fed with a High-Fat Diet. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32688114&form=6&db=m Sulfur and nitrogen-containing compounds from the whole bodies of Blaps japanensis. ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32688115&form=6&db=m p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32696986&form=6&db=m Intervention with the crude polysaccharides of Physalis pubescens L. mitigates colitis by preventing oxidative damage, aberrant immune responses, and dysbacteriosis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32698885&form=6&db=m Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32707279&form=6&db=m Discovery of novel aminophosphonate derivatives containing pyrazole moiety as potential selective COX-2 inhibitors. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32730652&form=6&db=m Maslinic acid prevents IL-1?-induced inflammatory response in osteoarthritis via PI3K/AKT/NF-?B pathways. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32742252&form=6&db=m Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer's Disease. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32743741&form=6&db=m Can aprepitant used for nausea and vomiting be good gastrointestinal complaints? diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32745911&form=6&db=m Ursolic acid protects chondrocytes, exhibits anti-inflammatory properties via regulation of the NF-?B/NLRP3 inflammasome pathway and ameliorates osteoarthritis. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32746641&form=6&db=m Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus (Jasonia Montana) growing in Egypt. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32747020&form=6&db=m Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-?B signaling axis. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32758571&form=6&db=m Dihydroxystilbenes prevent azoxymethane/dextran sulfate sodium-induced colon cancer by inhibiting colon cytokines, a chemokine, and programmed cell death-1 in C57BL/6J mice. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32771947&form=6&db=m Clostridium butyricum modulates gut microbiota and reduces colitis associated colon cancer in mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32774425&form=6&db=m Anti-Inflammatory Effects of Fermented Bark of Acanthopanax sessiliflorus and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32795152&form=6&db=m Arylidene analogues as selective COX-2 inhibitors: synthesis, characterization, in silico and in vitro studies. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32801214&form=6&db=m Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32802585&form=6&db=m The Effects of G2013 (?-L-guluronic Acid) in a Pentylenetetrazole-induced Kindling Animal Model of Epilepsy. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32803042&form=6&db=m Antiarthritic Potential of Comprehensively Standardized Extract of Alternanthera bettzickiana: In Vitro and In Vivo Studies. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32811507&form=6&db=m Discovery of the possible mechanisms in kouyanqing granule for treatment of oral ulcers based on network pharmacology. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32818610&form=6&db=m Combination of magnetic targeting with synergistic inhibition of NF-?B and glutathione via micellar drug nanomedicine enhances its anti-tumor efficacy. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32825257&form=6&db=m New 12,23-Epoxydammarane Type Saponins Obtained from Panax notoginseng Leaves and Their Anti-Inflammatory Activity. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32828009&form=6&db=m Radioiodination and in vivo assessment of the potential of newly synthesized pyrrolizine-5-carboxamides derivative in tumor model. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32832965&form=6&db=m A chondroprotective effect of moracin on IL-1?-induced primary rat chondrocytes and an osteoarthritis rat model through Nrf2/HO-1 and NF-?B axes. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850312&form=6&db=m Lack of Androgen Receptor Expression Selects for Basal-Like Phenotype and Is a Predictor of Poor Clinical Outcome in Non-Metastatic Triple Negative Breast Cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32859182&form=6&db=m Anti-inflammatory effect of Ganluyin, a Chinese classic prescription, in chronic pharyngitis rat model. diagnostic usage,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32860356&form=6&db=m Pharmacokinetic characterization of fluorocoxib D, a cyclooxygenase-2-targeted optical imaging agent for detection of cancer. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865065&form=6&db=m Antioxidant effect of acetyl-l-carnitine against cisplatin-induced cardiotoxicity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32867244&form=6&db=m Aryl Hydrocarbon Receptor Role in Co-Ordinating SARS-CoV-2 Entry and Symptomatology: Linking Cytotoxicity Changes in COVID-19 and Cancers; Modulation by Racial Discrimination Stress. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32867639&form=6&db=m The emerging role of COX-2, 15-LOX, and PPAR? in metabolic diseases and cancer: An introduction to novel multi-target directed ligands (MTDLs). ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32870428&form=6&db=m Premna odorata extract as a protective agent on neurotoxic effect of aluminum: neurochemical, molecular, and histopathological alterations. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32874582&form=6&db=m Expression of cyclooxygenase-2 and mucin 1 in colorectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32876071&form=6&db=m The anti-inflammatory activity of oligomeric proanthocyanidins via inhibition of NF-?B and MAPK in LPS-stimulated MAC-T cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32876916&form=6&db=m Anti-inflammatory and anti-oxidative effect of Korean propolis on Helicobacter pylori-induced gastric damage in vitro. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32886845&form=6&db=m Metformin and silymarin afford protection in cyclosporine A induced hepatorenal toxicity in rat by modulating redox status and inflammation. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32887288&form=6&db=m Wheat Bran Extract Regulates Mast Cell-Mediated Allergic Responses In Vitro and In Vivo. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32889812&form=6&db=m Expression of Cyclooxygenase-2 in Human Epithelial Skin Lesions: A Systematic Review of Immunohistochemical Studies. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32898532&form=6&db=m Zingerone attenuates vancomycin-induced hepatotoxicity in rats through regulation of oxidative stress, inflammation and apoptosis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32899627&form=6&db=m Design and Synthesis of a Novel NIR Celecoxib-Based Fluorescent Probe for Cyclooxygenase-2 Targeted Bioimaging in Tumor Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903591&form=6&db=m Rofecoxib Attenuates the Pathogenesis of Amyotrophic Lateral Sclerosis by Alleviating Cyclooxygenase-2-Mediated Mechanisms. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32903705&form=6&db=m Prognostic and Clinical Significance of Cyclooxygenase-2 Overexpression in Endometrial Cancer: A Meta-Analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32904445&form=6&db=m Inhibition of PI3K-AKT Signaling Blocks PGE2-Induced COX-2 Expression in Lung Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32915537&form=6&db=m Perfluorocarbon@Porphyrin Nanoparticles for Tumor Hypoxia Relief to Enhance Photodynamic Therapy against Liver Metastasis of Colon Cancer. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32931773&form=6&db=m Isoprenylcysteine carboxyl methyltransferase inhibitors exerts anti-inflammatory activity. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32933665&form=6&db=m Polygalactan from bivalve Crassostrea madrasensis attenuates nuclear factor-?B activation and cytokine production in lipopolysaccharide-activated macrophage. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942640&form=6&db=m Berry Phenolic and Volatile Extracts Inhibit Pro-Inflammatory Cytokine Secretion in LPS-Stimulated RAW264.7 Cells through Suppression of NF-?B Signaling Pathway. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32942772&form=6&db=m Cytotoxicity and Pro-Apoptotic, Antioxidant and Anti-Inflammatory Activities of Geopropolis Produced by the Stingless Bee Melipona fasciculata Smith. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32945205&form=6&db=m ?-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-?B and HO-1/Nrf-2 pathway. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32948076&form=6&db=m The Effect of miR-146a on the Gene Expression of Immunoregulatory Cytokines in Human Mesenchymal Stromal Cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32978284&form=6&db=m Repurposing [11C]PS13 for PET imaging of cyclooxygenase-1 (COX-1) in ovarian cancer xenograft mouse models. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982722&form=6&db=m The Role of Eicosanoids in Gynecological Malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32986614&form=6&db=m Inhibition of chikusetsusaponin IVa on inflammatory responses in RAW264.7 cell line via MAPK pathway. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32990777&form=6&db=m Roflumilast prevents lymphotoxin ? (TNF-?)-induced inflammation activation and degradation of type 2 collagen in chondrocytes. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32991863&form=6&db=m Pulchinenoside B4 exerts the protective effects against cisplatin-induced nephrotoxicity through NF-?B and MAPK mediated apoptosis signaling pathways in mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32997790&form=6&db=m A potential role for aspirin in the prevention and treatment of cholangiocarcinoma. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33005242&form=6&db=m Brilliant blue G attenuates neuro-inflammation via regulating MAPKs and NF-?B signaling pathways in lipopolysaccharide-induced BV2 microglia cells. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33006714&form=6&db=m Ellagic acid prevents kidney injury and oxidative damage via regulation of Nrf-2/NF-?B signaling in carbon tetrachloride induced rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33007930&form=6&db=m Development of Postoperative Pain in Patients with End-Stage Knee Osteoarthritis Is Associated with Upregulation of Genes Related to Extracellular Matrix Degradation, Inflammation, and Apoptosis Measured in the Peripheral Blood before Knee Surgery. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33008094&form=6&db=m Astaxanthin Suppresses PM2.5-Induced Neuroinflammation by Regulating Akt Phosphorylation in BV-2 Microglial Cells. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33014157&form=6&db=m Celecoxib upregulates ULBP-1 expression in lung cancer cells via the JNK/PI3K signaling pathway and increases susceptibility to natural killer cell cytotoxicity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33015829&form=6&db=m Design and synthesis of pyrazole-pyrazoline hybrids as cancer-associated selective COX-2 inhibitors. therapeutic application,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33015841&form=6&db=m Inhibitory effect of Jangkanghwan (Korean traditional food) on experimental ulcerative colitis in mice. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33016509&form=6&db=m ?2-AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33029092&form=6&db=m Anti-inflammatory effects of dexmedetomidine on human amnion-derived WISH cells. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33033563&form=6&db=m Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33035507&form=6&db=m 3-Deazaadenosine, an S-adenosylhomocysteine hydrolase inhibitor, attenuates lipopolysaccharide-induced inflammatory responses via inhibition of AP-1 and NF-?B signaling. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33040178&form=6&db=m Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33041039&form=6&db=m Colostrum supplementation with n-3 fatty acids does not alter calf outcome on a healthy commercial farm. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33044022&form=6&db=m An updated review of protective effects of rosemary and its active constituents against natural and chemical toxicities. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33048357&form=6&db=m Tumor resistance mechanisms and their consequences on ?? T cell activation. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050416&form=6&db=m Role of the Cyclooxygenase Pathway in the Association of Obstructive Sleep Apnea and Cancer. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33053754&form=6&db=m Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in A?1-42-Induced Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33057440&form=6&db=m KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi's sarcoma. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33058206&form=6&db=m Combination of white tea and peppermint demonstrated synergistic antibacterial and anti-inflammatory activities. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063931&form=6&db=m Astilbin prevents osteoarthritis development through the TLR4/MD-2 pathway. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33064371&form=6&db=m Thrombin-PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33066025&form=6&db=m Potential Anti-Skin Aging Effect of (-)-Catechin Isolated from the Root Bark of Ulmus davidiana var. japonica in Tumor Necrosis Factor-?-Stimulated Normal Human Dermal Fibroblasts. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33068759&form=6&db=m Anti-inflammatory effects of methanol extracts from the Antarctic lichen, Amandinea sp. in LPS-stimulated raw 264.7 macrophages and zebrafish. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33072916&form=6&db=m Down-regulation of COX-2 activity by 1?,25(OH)2D3 is VDR dependent in endothelial cells transformed by Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33081378&form=6&db=m Prostaglandin E2 Pathway Is Dysregulated in Gastric Adenocarcinoma in a Caucasian Population. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33082858&form=6&db=m Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacology. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33084638&form=6&db=m Anti-inflammatory and analgesic activities of indigo through regulating the IKK?/I?B/NF-?B pathway in mice. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33087032&form=6&db=m A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-small Cell Lung and Colorectal Cancers: Design, Synthesis, In Silico and In Vitro Studies Providing Mechanistic Insight into Their Anticancer Potencies. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33092149&form=6&db=m Standardized Fraction of Turbinaria ornata Alleviates Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice via Upregulation of FOXP3+ Regulatory T Cells. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33096924&form=6&db=m Polysulfide and Hydrogen Sulfide Ameliorate Cisplatin-Induced Nephrotoxicity and Renal Inflammation through Persulfidating STAT3 and IKK?. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33099940&form=6&db=m Postoperative efficacy of low-temperature plasma radiofrequency ablation in elderly patients with laryngeal carcinoma and its influences on tumor markers and COX-2 and VEGF expressions in laryngeal carcinoma tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33100904&form=6&db=m Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-?B Pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33116404&form=6&db=m Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117682&form=6&db=m Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33119867&form=6&db=m COX-2 Signaling in the Tumor Microenvironment. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33124671&form=6&db=m Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33131275&form=6&db=m Polyunsaturated Fatty Acid Diet and Upregulation of Lipoxin A4 Reduce the Inflammatory Response of Preeclampsia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33137555&form=6&db=m Discovery of novel sulfonamide-containing aminophosphonate derivatives as selective COX-2 inhibitors and anti-tumor candidates. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33142460&form=6&db=m Selenium relieves oxidative stress, inflammation, and apoptosis within spleen of chicken exposed to mercuric chloride. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33144437&form=6&db=m Additive Effects of Zinc Chloride on the Suppression of Hepatitis A Virus Replication by Interferon in Human Hepatoma Huh7 Cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33149866&form=6&db=m Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33151167&form=6&db=m Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33151664&form=6&db=m Exposure to Perfluorooctanoic Acid Induces Cognitive Deficits via Altering Gut Microbiota Composition, Impairing Intestinal Barrier Integrity, and Causing Inflammation in Gut and Brain. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33161117&form=6&db=m Cyclooxygenase and nitric oxide synthase pathways mediate the respiratory effects of TNF-? in rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33167334&form=6&db=m Targeting Lipid Peroxidation for Cancer Treatment. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33171861&form=6&db=m In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33172102&form=6&db=m Synthesis, 3D-QSAR, and Molecular Modeling Studies of Triazole Bearing Compounds as a Promising Scaffold for Cyclooxygenase-2 Inhibition. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33197057&form=6&db=m The expression profile and bioinformatics analysis of microRNAs in human bronchial epithelial cells treated by beryllium sulfate. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33201160&form=6&db=m Effects of (-)-epicatechin on neuroinflammation and hyperphosphorylation of tau in the hippocampus of aged mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33206422&form=6&db=m Topical application with conjugated linoleic acid ameliorates 2, 4-dinitrofluorobenzene-induced atopic dermatitis-like lesions in BALB/c mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33209047&form=6&db=m Sinapic Acid Inhibits IL-1?-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33209079&form=6&db=m The Protective Roles of Butein on Indomethacin Induced Gastric Ulcer in Mice. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33212290&form=6&db=m Tagitinin F has anti-inflammatory, anti-nociceptive and anti-matrix metalloproteinase properties: An in silico, in vitro and in vivo study. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33222263&form=6&db=m Pathological changes of frozen shoulder in rat model and the therapeutic effect of PPAR-? agonist. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33223820&form=6&db=m Prognostic Significance of Prostaglandin-Endoperoxide Synthase-2 Expressions in Human Breast Carcinoma: A Multiomic Approach. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33224219&form=6&db=m Two Novel Compounds with Tri-aryl Structures as Effective Anti-Breast Cancer Candidates In-vivo. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33227333&form=6&db=m Inhibition of HIF-1?/EP4 axis by hyaluronate-trimethyl chitosan-SPION nanoparticles markedly suppresses the growth and development of cancer cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33238839&form=6&db=m The Anti-inflammatory Effects of Lignan Glycosides from Cistanche tubulosa stems on LPS/IFN-?-induced RAW264.7 Macrophage Cells via PI3K/ AKT Pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33240646&form=6&db=m Deregulation of lysophosphatidic acid metabolism in oral cancer promotes cell migration via the up-regulation of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33241658&form=6&db=m Anti-coronavirus disease 2019 (COVID-19) targets and mechanisms of puerarin. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33246122&form=6&db=m Dendropanax dentiger (Harms) Merr. root and its major constituents exert therapeutic effect on adjuvant-induced arthritis in rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33251629&form=6&db=m Efficacy of hyaluronic acid on intervertebral disc inflammation: An in vitro study using notochordal cell lines and human disc cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33253929&form=6&db=m Adrenomedullin 2 attenuates LPS-induced inflammation in microglia cells by receptor-mediated cAMP-PKA pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33255023&form=6&db=m Lactoferrin-dual drug nanoconjugate: Synergistic anti-tumor efficacy of docetaxel and the NF-?B inhibitor celastrol. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33255507&form=6&db=m Hawthorn Herbal Preparation from Crataegus oxyacantha Attenuates In Vivo Carbon Tetrachloride -Induced Hepatic Fibrosis via Modulating Oxidative Stress and Inflammation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33255947&form=6&db=m A Sulfated Polysaccharide from Saccharina japonica Suppresses LPS-Induced Inflammation Both in a Macrophage Cell Model via Blocking MAPK/NF-?B Signal Pathways In Vitro and a Zebrafish Model of Embryos and Larvae In Vivo. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33260755&form=6&db=m Celecoxib Loaded In-Situ Provesicular Powder and Its In-Vitro Cytotoxic Effect for Cancer Therapy: Fabrication, Characterization, Optimization and Pharmacokinetic Evaluation. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33261130&form=6&db=m Natural Phenolic Acid, Product of the Honey Bee, for the Control of Oxidative Stress, Peritoneal Angiogenesis, and Tumor Growth in Mice. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33268476&form=6&db=m Designing a clinical trial of non-steroidal anti-inflammatory drugs for cancer pain: a survey of UK palliative care physicians. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33271940&form=6&db=m Acylpolyamine Mygalin as a TLR4 Antagonist Based on Molecular Docking and In Vitro Analyses. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33277861&form=6&db=m Relationship between cyclooxygenase-2 (COX-2) content and prognosis in nasopharyngeal carcinoma before and after radiochemotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33287198&form=6&db=m Panax ginseng Fruit Has Anti-Inflammatory Effect and Induces Osteogenic Differentiation by Regulating Nrf2/HO-1 Signaling Pathway in In Vitro and In Vivo Models of Periodontitis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33287464&form=6&db=m Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33291425&form=6&db=m Exopolysaccharide Isolated from Lactobacillus plantarum L-14 Has Anti-Inflammatory Effects via the Toll-Like Receptor 4 Pathway in LPS-Induced RAW 264.7 Cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33300198&form=6&db=m TGF-? acts as a dual regulator of COX-2/PGE2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/?-catenin pathways in colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33308098&form=6&db=m Anti-Inflammatory and Photoaging-Protective Effects of Olea europaea through Inhibition of AP-1 and NF-[Formula: see text] B Pathways. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33312127&form=6&db=m Irisin Protects Against Motor Dysfunction of Rats with Spinal Cord Injury via Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase-Nuclear Factor Kappa-B Pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33317054&form=6&db=m Particulate Matter-Induced Inflammation/Oxidative Stress in Macrophages: Fucosterol from Padina boryana as a Potent Protector, Activated via NF-?B/MAPK Pathways and Nrf2/HO-1 Involvement. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33325358&form=6&db=m [Aldo-keto reductase 1 member B1 (AKR1B1) inhibits retinal ganglion cell activity via activating NF-?B pathway and inducing mouse BV-2 microglia activation]. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33327467&form=6&db=m Prognostic Significance of COX-2 Overexpression in BRAF-Mutated Middle Eastern Papillary Thyroid Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33340158&form=6&db=m A review on pain-relieving activity of berberine. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33342821&form=6&db=m Pro-apoptotic and anti-neoplastic impact of luteolin on solid Ehrlich carcinoma.bearing mice exposed to gamma radiation. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343339&form=6&db=m Moringa oleifera Alkaloids Inhibited PC3 Cells Growth and Migration Through the COX-2 Mediated Wnt/?-Catenin Signaling Pathway. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343354&form=6&db=m Piperlongumine Alleviates Mouse Colitis and Colitis-Associated Colorectal Cancer. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343991&form=6&db=m COX-2 Overexpression in Schneiderian Papillomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33347680&form=6&db=m [6]-Gingerol impedes 7,12-dimethylbenz(a)anthracene-induced inflammation and cell proliferation-associated hamster buccal pouch carcinogenesis through modulating Nrf2 signaling events. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33359184&form=6&db=m Cassia sieberiana DC. leaves modulate LPS-induced inflammatory response in THP-1 cells and inhibit eicosanoid-metabolizing enzymes. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33359246&form=6&db=m Long non-coding RNA small nucleolar RNA host gene 1 alleviates the progression of epilepsy by regulating the miR-181a/BCL-2 axis in vitro. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33362544&form=6&db=m Chemical Composition of Pterospermum heterophyllum Root and its Anti-Arthritis Effect on Adjuvant-Induced Arthritis in Rats via Modulation of Inflammatory Responses. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33364964&form=6&db=m Eicosanoids in Cancer: New Roles in Immunoregulation. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33377567&form=6&db=m Investigating the anti-inflammatory effects of high molecular weight secretions from Limosilactobacillus reuteri PTCC 1655 on LPS-stimulated PMA-differentiated THP-1 cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33381264&form=6&db=m Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33389746&form=6&db=m Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33390773&form=6&db=m Mulberry leaves extract ameliorates alcohol-induced liver damages through reduction of acetaldehyde toxicity and inhibition of apoptosis caused by oxidative stress signals. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33396372&form=6&db=m Vanillic Acid, a Bioactive Phenolic Compound, Counteracts LPS-Induced Neurotoxicity by Regulating c-Jun N-Terminal Kinase in Mouse Brain. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33402361&form=6&db=m Inflammation Mediates the Development of Aggressive Breast Cancer Following Radiotherapy. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33408499&form=6&db=m Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33419132&form=6&db=m Cudratricusxanthone A Inhibits Lipid Accumulation and Expression of Inducible Nitric Oxide Synthase in 3T3-L1 Preadipocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33429006&form=6&db=m COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33430565&form=6&db=m Inflammatory Process and Molecular Targets for Antiinflammatory Nutraceuticals. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33433362&form=6&db=m Carica papaya leaf extract inhibits prostatitis-associated prostatic hyperplasia via the TRAF6/TAK1/MEK/NF-?B pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33443518&form=6&db=m Maltol inhibits the progression of osteoarthritis via the nuclear factor-erythroid 2-related factor-2/heme oxygenase-1 signal pathway in vitro and in vivo. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33454892&form=6&db=m N-Acetylcysteine Reduces miR-146a and NF-?B p65 Inflammatory Signaling Following Cadmium Hepatotoxicity in Rats. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33455946&form=6&db=m Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33456518&form=6&db=m Inhibitory effect of isomorellin on cholangiocarcinoma cells via suppression of NF-?B translocation, the phosphorylated p38 MAPK pathway and MMP-2 and uPA expression. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33465671&form=6&db=m Synthesis, structural characterization, molecular docking study, biological activity of carbon monoxide release molecules as potent antitumor agents. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33467104&form=6&db=m A Phase 1/2 Study of Flavocoxid, an Oral NF-?B Inhibitor, in Duchenne Muscular Dystrophy. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33469504&form=6&db=m Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33473256&form=6&db=m miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33474794&form=6&db=m Dietary exposure to bisphenol A affects memory function and neuroimmune biomarkers in allergic asthmatic mice. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33483066&form=6&db=m Development and pharmacological evaluation of vancomycin loaded chitosan films. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485865&form=6&db=m AGEs exacerbates coronary microvascular dysfunction in NoCAD by activating endoplasmic reticulum stress-mediated PERK signaling pathway. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33489032&form=6&db=m Curcumin inhibits APOE4-induced injury by activating peroxisome proliferator-activated receptor-? (PPAR?) in SH-SY5Y cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33489777&form=6&db=m Hepatoprotective, antioxidant and, anti-inflammatory potentials of gallic acid in carbon tetrachloride-induced hepatic damage in Wistar rats. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33489875&form=6&db=m Emodin Inhibits Inflammation, Carcinogenesis, and Cancer Progression in the AOM/DSS Model of Colitis-Associated Intestinal Tumorigenesis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33490681&form=6&db=m Ellagic acid restored lead-induced nephrotoxicity by anti-inflammatory, anti-apoptotic and free radical scavenging activities. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33498967&form=6&db=m Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33511940&form=6&db=m Dual Human Carbonic Anhydrase/Cyclooxygenase-2 Inhibitors: A Promising Approach for Cancer Treatment. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33517187&form=6&db=m Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33519479&form=6&db=m Piceatannol Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Modulation of Nrf2/HO-1/NF?B Axis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33524178&form=6&db=m Use of quantitative real-time PCR to determine the local inflammatory response in the intestinal mucosa and muscularis of horses undergoing small intestinal resection. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33528898&form=6&db=m Phytochemical Profile and Anti-Inflammatory Activity of the Fraction from Artemisia lavandulaefolia. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33537696&form=6&db=m Nanoscale photosensitizer with tumor-selective turn-on fluorescence and activatable photodynamic therapy treatment for COX-2 overexpressed cancer cells. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33545218&form=6&db=m A carrier-free anti-inflammatory platinum (II) self-delivered nanoprodrug for enhanced breast cancer therapy. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33546238&form=6&db=m Non-Steroidal Anti-Inflammatory Drugs in Colorectal Cancer Chemoprevention. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33559824&form=6&db=m Potential therapeutic effects of Ulva lactuca water fraction on monosodium glutamate-induced testicular and prostatic tissue damage in rats. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33563883&form=6&db=m Anti-inflammatory Effects of Sanhuang-Siwu-Tang in Lipopolysaccharide-Stimulated RAW264.7 Macrophages and BV2 Microglial Cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33568729&form=6&db=m Pluripotency and immunomodulatory signatures of canine induced pluripotent stem cell-derived mesenchymal stromal cells are similar to harvested mesenchymal stromal cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570264&form=6&db=m Enhanced expression of cyclooxygenase-2 related multi-drug resistance gene in melanoma and osteosarcoma cell lines by TSG-6 secreted from canine adipose-derived mesenchymal stem/stromal cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33573189&form=6&db=m Hyperglycemic Condition Causes Pro-Inflammatory and Permeability Alterations Associated with Monocyte Recruitment and Deregulated NF?B/PPAR? Pathways on Cerebral Endothelial Cells: Evidence for Polyphenols Uptake and Protective Effect. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33573388&form=6&db=m LINC00461 Promoted Endometrial Carcinoma Growth and Migration by Targeting MicroRNA-219-5p/Cyclooxygenase-2 Signaling Axis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33573560&form=6&db=m Study on the Anti-Tumor Mechanism and Target of Triptolide based on Network Pharmacology and Molecular Docking. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33577919&form=6&db=m Cadmium induced inflammation and apoptosis of porcine epididymis via activating RAF1/MEK/ERK and NF-?B pathways. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33578254&form=6&db=m A novel immunochemotherapy based on targeting of cyclooxygenase and induction of immunogenic cell death. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33579032&form=6&db=m Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33582168&form=6&db=m Computational pharmacology and bioinformatics to explore the potential mechanism of Schisandra against atherosclerosis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33584298&form=6&db=m Extracellular ATP Mediates Cancer Cell Migration and Invasion Through Increased Expression of Cyclooxygenase 2. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33586347&form=6&db=m One-Pot Synthesis of Coumarin-Indomethacin Hybrids as COX-2 Targeting Probes for Cancer Imaging. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33588045&form=6&db=m Anti-inflammatory activity of ortho-trifluoromethoxy-substituted 4-piperidione-containing mono-carbonyl curcumin derivatives in vitro and in vivo. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33588911&form=6&db=m Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33595108&form=6&db=m Dieckol isolated from a brown alga, Eisenia nipponica, suppresses ear swelling from allergic inflammation in mouse. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33609541&form=6&db=m McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616153&form=6&db=m Adiponectin inhibits lipoplysaccharide-induced inflammation and promotes osteogenesis in hPDLCs. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33616827&form=6&db=m Neuroprotective Effect of Fisetin Against the Cerebral Ischemia-Reperfusion Damage via Suppression of Oxidative Stress and Inflammatory Parameters. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33619313&form=6&db=m Three-dimensional structure of human cyclooxygenase (hCOX)-1. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33626425&form=6&db=m Artemisiae Iwayomogii Herba inhibits lipopolysaccharide-induced neuroinflammation by regulating NF-?B and MAPK signaling pathways. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33628374&form=6&db=m Levels of Cyclooxygenase 2, Interleukin-6, and Tumour Necrosis Factor-? in Fibroblast Cell Culture Models after Photobiomodulation at 660?nm. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33628387&form=6&db=m Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33632047&form=6&db=m An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33641674&form=6&db=m COX2 expression is associated with preoperative tumor volume but not with volumetric tumor growth in vestibular schwannoma. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33645090&form=6&db=m [Mechanism of Danggui Sini Decoction in treatment of primary dysmenorrhea based on network pharmacology and molecular docking]. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33652541&form=6&db=m Enriched environment housing improved the laying hen's resistance to transport stress via modulating the heat shock protective response and inflammation. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33655604&form=6&db=m Exposure to chewing tobacco promotes primary oral squamous cell carcinoma and regional lymph node metastasis by alterations of SDF1?/CXCR4 axis. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660801&form=6&db=m Curcumin-Celecoxib: a synergistic and rationale combination chemotherapy for breast cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33666626&form=6&db=m Cardamonin protects nucleus pulposus cells against IL-1?-induced inflammation and catabolism via Nrf2/NF-?B axis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33667839&form=6&db=m Piperine and Celecoxib synergistically inhibit colon cancer cell proliferation via modulating Wnt/?-catenin signaling pathway. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33668160&form=6&db=m Prostaglandin E2 Receptor 4 (EP4) as a Therapeutic Target to Impede Breast Cancer-Associated Angiogenesis and Lymphangiogenesis. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33672553&form=6&db=m Health Potential of Aloe vera against Oxidative Stress Induced Corneal Damage: An "In Vitro" Study. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33685048&form=6&db=m [Angiopoietin-2 regulates vessels encapsulated by tumor clusters positive hepatocellular carcinoma nest-type metastasis via integrin ?5?1]. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33693730&form=6&db=m Trace amounts of antibiotic exacerbated diarrhea and systemic inflammation of weaned pigs infected with a pathogenic Escherichia coli. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33706122&form=6&db=m Automatic evaluation of cyclooxygenase 2 inhibition induced by metal-based anticancer compounds. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33711550&form=6&db=m Pharmacological evaluation of continentalic acid for antidiabetic potential. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33711984&form=6&db=m Validating potent anti-inflammatory and anti-rheumatoid properties of Drynaria quercifolia rhizome methanolic extract through in vitro, in vivo, in silico and GC-MS-based profiling. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33718229&form=6&db=m Cyclooxygenase-2 Inhibitor: A Potential Combination Strategy With Immunotherapy in Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33727430&form=6&db=m Japanese quince (Chaenomeles japonica) leaf phenol extract as modulator of the inflammatory response in lipopolysaccharide-triggered murine macrophage RAW 264.7 cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33732362&form=6&db=m Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33737826&form=6&db=m Efficacy of a Standardized Turmeric Extract Comprised of 70% Bisdemothoxy-Curcumin (REVERC3) Against LPS-Induced Inflammation in RAW264.7 Cells and Carrageenan-Induced Paw Edema. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33739884&form=6&db=m Intestinal Anti-Inflammatory Effects of Selenized Ulva pertusa Polysaccharides in a Dextran Sulfate Sodium-Induced Inflammatory Bowel Disease Model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33739886&form=6&db=m Pinocembrin Reduces Arthritic Symptoms in Mouse Model via Targeting Sox4 Signaling Molecules. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33749107&form=6&db=m Panax ginseng modulates oxidative stress, DNA damage, apoptosis, and inflammations induced by silicon dioxide nanoparticles in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33749522&form=6&db=m Rifampicin ameliorates lipopolysaccharide-induced cognitive and motor impairments via inhibition of the TLR4/MyD88/NF-?B signaling pathway in mice. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751829&form=6&db=m The role of COX expression in the prognostication of overall survival of canine and feline cancer: A systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33763481&form=6&db=m Human Interferon Inducible Transmembrane Protein 3 (IFITM3) Inhibits Influenza Virus A Replication and Inflammation by Interacting with ABHD16A. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33768340&form=6&db=m Circulating prostaglandin E2: a novel potential prognostic biomarker in patients with hepatocellular carcinoma. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33769089&form=6&db=m Involvement of Rho-kinase/I?B-?/NF-?B activation in IL-1?-induced inflammatory response and oxidative stress in human chondrocytes. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33774936&form=6&db=m Establishment of inflammatory model induced by Pseudorabies virus infection in mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33790105&form=6&db=m T-Cell Activation-Inhibitory Assay to Screen Caloric Restriction Mimetics Drugs for Drug Repositioning. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33794252&form=6&db=m Co-administration of 5FU and propolis on AOM/DSS induced colorectal cancer in BALB-c mice. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33797378&form=6&db=m Antioxidant, Anti-Inflammatory and Anticancer Activities of Methanolic Extract of Thottea siliquosa: An In Vitro and In Silico Study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33799974&form=6&db=m Malonic Acid Isolated from Pinus densiflora Inhibits UVB-Induced Oxidative Stress and Inflammation in HaCaT Keratinocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33800000&form=6&db=m Potential Role of Curcumin and Its Nanoformulations to Treat Various Types of Cancers. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33801351&form=6&db=m 15-Deoxy-?12,14-prostaglandin J2 Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33803551&form=6&db=m Protective Effects of Taurine Chloramine on Experimentally Induced Colitis: NF?B, STAT3, and Nrf2 as Potential Targets. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33805675&form=6&db=m Development and In Vitro Evaluation of 2-Methoxyestradiol Loaded Polymeric Micelles for Enhancing Anticancer Activities in Prostate Cancer. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33808594&form=6&db=m Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33809304&form=6&db=m Lutonarin from Barley Seedlings Inhibits the Lipopolysacchride-Stimulated Inflammatory Response of RAW 264.7 Macrophages by Suppressing Nuclear Factor-?B Signaling. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33812268&form=6&db=m Steroidal alkaloids from the bulbs of Fritillaria pallidiflora Schrenk and their anti-inflammatory activity. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33812575&form=6&db=m Surface modified multifaceted nanocarriers for oral non-conventional cancer therapy; synthesis and evaluation. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33815556&form=6&db=m Network Pharmacology Analysis of Traditional Chinese Medicine Formula Shuang Di Shou Zhen Tablets Treating Nonexudative Age-Related Macular Degeneration. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33821899&form=6&db=m Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) Randomized Clinical Trial. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33826808&form=6&db=m A review on chemistry, source and therapeutic potential of lambertianic acid. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33828386&form=6&db=m Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33836205&form=6&db=m Synthesis and anti-inflammatory activity of novel steroidal chalcones with 3?-pregnenolone ester derivatives in RAW 264.7 cells in vitro. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33840168&form=6&db=m Identification of potential candidate genes for lip and oral cavity cancer using network analysis. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33844304&form=6&db=m Farrerol ameliorate adjuvant-induced ankle injury via alteration of PPAR-? signal pathway. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33848773&form=6&db=m Antihypertensive potential of selected pyrimidine derivatives: Explanation of underlying mechanistic pathways. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854358&form=6&db=m Natural Dietary Supplement, Carvacrol, Alleviates LPS-Induced Oxidative Stress, Neurodegeneration, and Depressive-Like Behaviors via the Nrf2/HO-1 Pathway. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854702&form=6&db=m Synthesis, Inhibitory Activity, and In Silico Modeling of Selective COX-1 Inhibitors with a Quinazoline Core. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33875721&form=6&db=m The impact of damage-associated molecules released from canine tumor cells on gene expression in macrophages. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33878544&form=6&db=m Decursin alleviates the aggravation of osteoarthritis via inhibiting PI3K-Akt and NF-kB signal pathway. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33889764&form=6&db=m Pharmacophore model, docking, QSAR, and molecular dynamics simulation studies of substituted cyclic imides and herbal medicines as COX-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33893687&form=6&db=m Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33918063&form=6&db=m Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33924583&form=6&db=m Phaseolin Attenuates Lipopolysaccharide-Induced Inflammation in RAW 264.7 Cells and Zebrafish. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33925400&form=6&db=m The Anti-Cancer Effects of a Zotarolimus and 5-Fluorouracil Combination Treatment on A549 Cell-Derived Tumors in BALB/c Nude Mice. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33925793&form=6&db=m Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33927611&form=6&db=m Danhong Injection Attenuates Cerebral Ischemia-Reperfusion Injury in Rats Through the Suppression of the Neuroinflammation. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33927774&form=6&db=m The Underlying Molecular Mechanisms Involved in Traditional Chinese Medicine Smilax china L. for the Treatment of Pelvic Inflammatory Disease. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33939091&form=6&db=m Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33953587&form=6&db=m Forsythoside A Alleviates High Glucose-Induced Oxidative Stress and Inflammation in Podocytes by Inactivating MAPK Signaling via MMP12 Inhibition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33958857&form=6&db=m OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33967512&form=6&db=m Immunohistochemical analysis and correlation of cyclooxygenase-2 expression status with clinicopathological parameters in head and neck squamous cell carcinomas: An Indian perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33969138&form=6&db=m PTGS2 Over-Expression: A Colorectal Carcinoma Initiator not an Invasive Factor. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33977594&form=6&db=m Rotundic acid reduces LPS-induced acute lung injury in vitro and in vivo through regulating TLR4 dimer. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33978372&form=6&db=m Significance of Serum Markers and Urinary Microalbumin in the Diagnosis of Early Renal Damage in Patients with Gout. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33991638&form=6&db=m The anti-inflammatory effects of an ethanolic extract of the rhizome of Atractylodes lancea, involves Akt/NF-?B signaling pathway inhibition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34010516&form=6&db=m Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34012471&form=6&db=m Mogroside V Alleviates Lipopolysaccharide-Induced Neuroinflammation via Inhibition of TLR4-MyD88 and Activation of AKT/AMPK-Nrf2 Signaling Pathway. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34025136&form=6&db=m Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34033814&form=6&db=m Aspirin inhibits prostaglandins to prevents colon tumor formation via down-regulating Wnt production. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055089&form=6&db=m Anti-inflammatory role of curcumin in retinal disorders (Review). therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055228&form=6&db=m Development of Fluorescence Imaging Probes for Labeling COX-1 in Live Ovarian Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34063048&form=6&db=m Inhibition of Lipid Accumulation and Cyclooxygenase-2 Expression in Differentiating 3T3-L1 Preadipocytes by Pazopanib, a Multikinase Inhibitor. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071911&form=6&db=m The Anti-Oxidative and Anti-Neuroinflammatory Effects of Sargassum horneri by Heme Oxygenase-1 Induction in BV2 and HT22 Cells. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34072428&form=6&db=m Cinnamon Extract and Probiotic Supplementation Alleviate Copper-Induced Nephrotoxicity via Modulating Oxidative Stress, Inflammation, and Apoptosis in Broiler Chickens. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34081755&form=6&db=m Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration. diagnostic usage,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34084214&form=6&db=m Cyclooxygenase-2 expression is associated with chemoresistance through cancer stemness property in hypopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34088885&form=6&db=m Revealing the therapeutic targets and molecular mechanisms of emodin-treated coronavirus disease 2019 via a systematic study of network pharmacology. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34093801&form=6&db=m MicroRNA-30a-3p acts as a tumor suppressor in MHCC-97H hepatocellular carcinoma cells by targeting COX-2. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094895&form=6&db=m Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34095106&form=6&db=m The Calcium-Sensing Receptor Is Involved in Follicle-Stimulating Hormone-Induced Cumulus Expansion in in vitro Cultured Porcine Cumulus-Oocyte Complexes. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34102280&form=6&db=m Iminodibenzyl redirected cyclooxygenase-2 catalyzed dihomo-?-linolenic acid peroxidation pattern in lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34103896&form=6&db=m Novel Phenolic Compounds as Potential Dual EGFR and COX-2 Inhibitors: Design, Semisynthesis, in vitro Biological Evaluation and in silico Insights. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34115226&form=6&db=m Protective effect of (+)-catechin against lipopolysaccharide-induced inflammatory response in RAW 264.7 cells through downregulation of NF-?B and p38 MAPK. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34124763&form=6&db=m Bis(ethylmaltolato)oxidovanadium (IV) attenuates amyloid-beta-mediated neuroinflammation by inhibiting NF-?B signaling pathway via a PPAR?-dependent mechanism. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34144282&form=6&db=m Effects of an oral hydro-ethanolic purple coneflower extract on performance, clinical health and immune parameters in calves. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34145398&form=6&db=m E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149447&form=6&db=m Enhanced Immune Response Improves Resistance to Cadmium Stress in Triploid Crucian Carp. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34149863&form=6&db=m Molecular Targets and Mechanisms of Scutellariae radix-Coptidis rhizoma Drug Pair for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34162145&form=6&db=m Therapeutic perspective of thiosemicarbazones derivatives in inflammatory pathologies: A summary of in vitro/in vivo studies. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34166113&form=6&db=m Allogenic Pure Platelet-Rich Plasma Therapy for Adhesive Capsulitis: A Bed-to-Bench Study With Propensity Score Matching Using a Corticosteroid Control Group. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168274&form=6&db=m The preventive effects of aspirin on preeclampsia based on network pharmacology and bioinformatics. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34174268&form=6&db=m Concomitant use of analgesics and immune checkpoint inhibitors in non-small cell lung cancer: A pharmacodynamics perspective. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34177406&form=6&db=m Coriandrum sativum attenuates microglia mediated neuroinflammation and MPTP-induced behavioral and oxidative changes in Parkinson's disease mouse model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34178680&form=6&db=m The Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34180760&form=6&db=m MicroRNA-183-5p protects human derived cell line SH-SY5Y cells from mepivacaine-induced injury. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34193669&form=6&db=m Boeravinone B Protects Brain against Cerebral Ichemia Reperfusion Injury in Rats: Possible Role of Anti-inflammatory and Antioxidant. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34194533&form=6&db=m Investigating the Multitarget Pharmacological Mechanism of Ursolic Acid Acting on Colon Cancer: A Network Pharmacology Approach. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34199169&form=6&db=m The Role of Prostaglandins in Different Types of Cancer. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34201431&form=6&db=m Stress-Related Regulation Is Abnormal in the Psoriatic Uninvolved Skin. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34201732&form=6&db=m Ex Vivo Study on the Antioxidant Activity of a Winemaking By-Product Polyphenolic Extract (Taurisolo®) on Human Neutrophils. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34213019&form=6&db=m Autophagy upregulates inflammatory cytokines in gingival tissue of patients with periodontitis and lipopolysaccharide-stimulated human gingival fibroblasts. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34220524&form=6&db=m He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic Study. therapeutic application,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34229253&form=6&db=m Anti-inflammatory activities of amber extract in lipopolysaccharide-induced RAW 264.7 macrophages. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34234507&form=6&db=m Upregulation of COX-2 and PGE2 Induced by TNF-? Mediated Through TNFR1/MitoROS/PKC?/P38 MAPK, JNK1/2/FoxO1 Cascade in Human Cardiac Fibroblasts. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34234674&form=6&db=m Angelica Dahurica Regulated the Polarization of Macrophages and Accelerated Wound Healing in Diabetes: A Network Pharmacology Study and In Vivo Experimental Validation. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34237707&form=6&db=m ?-Cyperone (CYP) down-regulates NF-?B and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34238176&form=6&db=m The protective role of etoricoxib against diethylnitrosamine/2-acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: The impact of NF-?B/COX-2/PGE2 signaling. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34243072&form=6&db=m Enhancing the tumor cell selectivity of a rhodamine-decorated iridium(III) complex by conjugating with indomethacin for COX-2 targeted photodynamic therapy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34251811&form=6&db=m PEP27-2, a Potent Antimicrobial Cell-Penetrating Peptide, Reduces Skin Abscess Formation during Staphylococcus aureus Infections in Mouse When Used in Combination with Antibiotics. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34254099&form=6&db=m Synthesis, characterization, and cellular investigations of porphyrin- and chlorin-indomethacin conjugates for photodynamic therapy of cancer. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34262962&form=6&db=m Metformin Inhibits Lipoteichoic Acid-Induced Oxidative Stress and Inflammation Through AMPK/NRF2/NF-?B Signaling Pathway in Bovine Mammary Epithelial Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34264123&form=6&db=m Celecoxib repurposing in cancer therapy: molecular mechanisms and nanomedicine-based delivery technologies. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34265298&form=6&db=m Therapeutic effect of berberine on chronic atrophic gastritis based on plasma and urine metabolisms. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34268031&form=6&db=m The Modulating Effect of Ursodeoxycholic Acid on Liver Tissue Cyclooxygenase-2 Expression Following Extended Hepatectomy. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34275700&form=6&db=m Insights into cyclooxygenase-2 inhibition by isolated bioactive compounds 3-caffeoyl-4-dihydrocaffeoyl quinic acid and isorhamnetin 3-O-?-D-glucopyranoside from Salicornia herbacea. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34281416&form=6&db=m Isoginkgetin treatment attenuated lipopolysaccharide-induced monoamine neurotransmitter deficiency and depression-like behaviors through downregulating p38/NF-?B signaling pathway and suppressing microglia-induced apoptosis. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34288236&form=6&db=m Inflammatory repercussions in female steroid responsive glands after perinatal exposure to bisphenol A and 17-? estradiol. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34303896&form=6&db=m Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34314467&form=6&db=m Cyclooxygenase-2 expression in colorectal carcinoma, adenomatous polyps and non-tumour bearing margins of resection tissues in a cohort of black Africans. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34315042&form=6&db=m 1,10-Seco-Eudesmane sesquiterpenoids as a new type of anti-neuroinflammatory agents by suppressing TLR4/NF-?B/MAPK pathways. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34316376&form=6&db=m lncRNA-PACER upregulates COX-2 and PGE2 through the NF-?B pathway to promote the proliferation and invasion of colorectal-cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34326917&form=6&db=m Computational and Preclinical Evidence of Anti-ischemic Properties of L-Carnitine-Rich Supplement via Stimulation of Anti-inflammatory and Antioxidant Events in Testicular Torsed Rats. ongoing research,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34331683&form=6&db=m Targeting Nuclear Factor-Kappa B Signaling Pathway by Curcumin: Implications for the Treatment of Multiple Sclerosis. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34332066&form=6&db=m A comparative study on chemical compositions and biological activities of four essential oils: Cymbopogon citratus (DC.) Stapf, Cinnamomum cassia (L.) Presl, Salvia japonica Thunb. and Rosa rugosa Thunb. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34341904&form=6&db=m Preliminary evaluation of anticancer efficacy of pioglitazone combined with celecoxib for the treatment of non-small cell lung cancer. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34344946&form=6&db=m Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34345856&form=6&db=m Wheatgrass inhibits the lipopolysaccharide-stimulated inflammatory effect in RAW 264.7 macrophages. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34349636&form=6&db=m Acupuncture Can Regulate the Peripheral Immune Cell Spectrum and Inflammatory Environment of the Vascular Dementia Rat, and Improve the Cognitive Dysfunction of the Rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34356673&form=6&db=m Celecoxib Analogues for Cancer Treatment: An Update on OSU-03012 and 2,5-Dimethyl-Celecoxib. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34361836&form=6&db=m Anti-Cancer Effects of Zotarolimus Combined with 5-Fluorouracil Treatment in HCT-116 Colorectal Cancer-Bearing BALB/c Nude Mice. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34366627&form=6&db=m Genetic variant of cyclooxygenase-2 in gastric cancer: More inflammation and susceptibility. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34369548&form=6&db=m 18?-Glycyrrhetinic acid inhibits IL-1?-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34373695&form=6&db=m Chitosan and Curcumin Nanoformulations against Potential Cardiac Risks Associated with Hydroxyapatite Nanoparticles in Wistar Male Rats. diagnostic usage,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34386086&form=6&db=m Inhibition of photodynamic therapy induced-immunosuppression with aminolevulinic acid leads to enhanced outcomes of tumors and pre-cancerous lesions. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34387320&form=6&db=m Hepatoprotective effect of Spirulina platensis against carbon tetrachloride-induced liver injury in male rats. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34389281&form=6&db=m MicroRNA and cyclooxygenase-2 in breast cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34392440&form=6&db=m Ursodeoxycholic acid shows antineoplastic effects in bile duct cancer cells via apoptosis induction; p53 activation; and EGFR-ERK, COX-2, and PI3K-AKT pathway inhibition. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34394377&form=6&db=m Data Mining, Network Pharmacology, and Molecular Docking Explore the Effects of Core Traditional Chinese Medicine Prescriptions in Patients with Rectal Cancer and Qi and Blood Deficiency Syndrome. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395029&form=6&db=m Inhibitory effects of Humulus japonicus extract against hepatic injury in a diabetic rat model. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34403776&form=6&db=m Isolation and characterization of phellodendronoside A, a new isoquinoline alkaloid glycoside with anti-inflammatory activity from Phellodendron chinense Schneid. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34403978&form=6&db=m Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34419138&form=6&db=m Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34422216&form=6&db=m Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the Nrf2 Signaling Pathway. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34424685&form=6&db=m Development of Rofecoxib-Based Fluorescent Probes and Investigations on Their Solvatochromism, AIE Activity, Mechanochromism, and COX-2-Targeted Bioimaging. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34426770&form=6&db=m Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34429597&form=6&db=m Albumin-encapsulated Nanoparticles of Naproxen Platinum(IV) Complexes with Inflammation Inhibitory Competence Displaying Effective Antitumor Activities in vitro and in vivo. therapeutic application,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34430611&form=6&db=m Cannabinoid receptor agonist WIN55212-2 reduces unpredictable mild stress-induced depressive behavior of rats. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34436652&form=6&db=m Diclofenac down-regulates COX-2 induced expression of CD44 and ICAM-1 in human HT29 colorectal cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445132&form=6&db=m Anti-Inflammatory and Anti-Allergic Effects of Saponarin and Its Impact on Signaling Pathways of RAW 264.7, RBL-2H3, and HaCaT Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34445685&form=6&db=m A Combination of Celecoxib and Glucosamine Sulfate Has Anti-Inflammatory and Chondroprotective Effects: Results from an In Vitro Study on Human Osteoarthritic Chondrocytes. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34448457&form=6&db=m Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-?B inhibition in macrophages. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34451589&form=6&db=m Bioactivity-Guided Extract Optimization of Osmanthus fragrans var. aurantiacus Leaves and Anti-Inflammatory Activities of Phillyrin. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34456930&form=6&db=m Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34466408&form=6&db=m High Immunoexpression of COX-2 as a Metastatic Risk Factor in ccRCC without PD-L1 Involvement. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34466703&form=6&db=m Perspiration promotes the effect of sulphite on the shielding response of rodent skin. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34468508&form=6&db=m Toxicological effects of thimerosal on rat kidney: a histological and biochemical study. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34468509&form=6&db=m Mitigation of cisplatin induced nephrotoxicity by casticin in male albino rats. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34478828&form=6&db=m GPER and IGF-1R mediate the anti-inflammatory effect of genistein against lipopolysaccharide (LPS)-induced nigrostriatal injury in rats. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34495750&form=6&db=m Prefrontal Cortex and Hippocampus Inflammation in Mice Fed High-Carbohydrate or High-Fat Diets. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34497154&form=6&db=m Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34502415&form=6&db=m Isoleucilactucin Ameliorates Coal Fly Ash-Induced Inflammation through the NF-?B and MAPK Pathways in MH-S Cells. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34505250&form=6&db=m Neurotoxicity and neuroinflammatory effects of bisphenol A in male rats: the neuroprotective role of grape seed proanthocyanidins. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34509933&form=6&db=m FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway. ongoing research,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34515014&form=6&db=m Molecular and Metabolomic Investigation of Celecoxib Antiproliferative Activity in Mono-and Combination Therapy Against Breast Cancer Cell Models. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34517063&form=6&db=m Ethanolic extract of Pyrus pashia buch ham ex. D. Don (Kainth): A bioaccessible source of polyphenols with anti-inflammatory activity in vitro and in vivo. ongoing research,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34517157&form=6&db=m Gene expression analysis of invasive breast carcinoma yields differential patterns in luminal subtypes of breast cancer. causal interaction,unassigned 2,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34520827&form=6&db=m Anti-neuroinflammatory activity of 6,7-dihydroxy-2,4-dimethoxy phenanthrene isolated from Dioscorea batatas Decne partly through suppressing the p38 MAPK/NF-?B pathway in BV2 microglial cells. causal interaction,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34521024&form=6&db=m Baicalin protects against zearalenone-induced chicks liver and kidney injury by inhibiting expression of oxidative stress, inflammatory cytokines and caspase signaling pathway. unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34528556&form=6&db=m Diagnostic potential of differentially regulated microRNAs among endometriosis, endometrioid ovarian cancer, and endometrial cancer. diagnostic usage,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34531989&form=6&db=m Bracteanolide A abrogates oxidative stress-induced cellular damage and protects against hepatic ischemia and reperfusion injury in rats. causal interaction,unassigned 1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34543639&form=6&db=m Regulation of inflammation and COX-2 gene expression in benzo (a) pyrene induced lung carcinogenesis in mice by all trans retinoic acid (ATRA). causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100033875&form=6&db=m Antioxidant, anti-proliferative and cyclooxygenase-2 inhibitory activities of ethanolic extracts from lemon balm (Melissa officinalis L.) leaves unassigned -
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100059629&form=6&db=m Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100080262&form=6&db=m Anti-inflammatory activity of lansais from endophytic Streptomyces sp. SUC1 in LPS-induced RAW 264.7 cells ongoing research,unassigned 4,0
1.14.99.1 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=100533598&form=6&db=m Labdane diterpenes in Curcuma mangga rhizomes inhibit lipid peroxidation, cyclooxygenase enzymes and human tumour cell proliferation ongoing research,unassigned 2,0
1.14.99.1 Neoplasms, Basal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051365&form=6&db=m Beyond the scalpel: targeting hedgehog in skin cancer prevention. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neoplasms, Glandular and Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162632&form=6&db=m Ultraviolet B(UVB)-induced cox-2 expression in murine skin: an immunohistochemical study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplasms, Glandular and Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11889377&form=6&db=m Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplasms, Glandular and Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126310&form=6&db=m Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neoplasms, Glandular and Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17523957&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in canine ovarian carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplasms, Glandular and Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645803&form=6&db=m Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neoplasms, Neuroepithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1910078&form=6&db=m A study on the biological behavior of human brain tumors. Part I. Arachidonic acid metabolism and DNA content. causal interaction,unassigned 3,0
1.14.99.1 Neoplasms, Neuroepithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661344&form=6&db=m First experiences with low-dose anti-angiogenic treatment in gliomatosis cerebri with signs of angiogenic activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Neoplasms, Radiation-Induced http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28956695&form=6&db=m Tumor Cell Invasion Induced by Radiation in Balb/C Mouse is Prevented by the Cox-2 Inhibitor NS-398. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10226539&form=6&db=m Expression of cyclooxygenase-2 in human squamous cell carcinoma of the esophagus; an immunohistochemical survey. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11688844&form=6&db=m Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745262&form=6&db=m COX-2 expression in dysplasia of the head and neck: correlation with elF4E. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12698187&form=6&db=m Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313895&form=6&db=m Cyclooxygenase-1 deletion enhances apoptosis but does not protect against ultraviolet light-induced tumors. therapeutic application,unassigned 4,0
1.14.99.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18275990&form=6&db=m Cyclooxygenase-2 in cervical neoplasia: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460857&form=6&db=m Epithelial to mesenchymal transition in cutaneous squamous cell carcinoma is correlated with COX-2 expression but not with the presence of stromal macrophages or CD10-expressing cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23384501&form=6&db=m Cox-2 in non-small cell lung cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,3
1.14.99.1 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26959737&form=6&db=m MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16872953&form=6&db=m Perioperative cyclooxygenase 2 inhibition to reduce tumor cell adhesion and metastatic potential of circulating tumor cells in non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17429393&form=6&db=m Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30082142&form=6&db=m The prognostic value of COX-2 expression on circulating tumor cells in nasopharyngeal carcinoma: A prospective analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30260024&form=6&db=m Associations between the cyclooxygenase-2 expression in circulating tumor cells and the clinicopathological features of patients with colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Neoplastic Cells, Circulating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31486495&form=6&db=m Clinical significance of circulating tumor cells and their expression of cyclooxygenase-2 in patients with nasopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Neoplastic Processes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753376&form=6&db=m p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Neoplastic Processes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15858127&form=6&db=m Cyclooxygenase 2 expression in nasopharyngeal carcinoma: immunohistochemical findings and potential implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,3
1.14.99.1 Neoplastic Processes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18201240&form=6&db=m Cyclooxygenase-2 expression in dermatofibroma and dermatofibrosarcoma protuberans. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neoplastic Processes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925514&form=6&db=m Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Neoplastic Processes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25301050&form=6&db=m CXCR-4 and COX-2 Expression in Basal Cell Carcinomas and Well-Differentiated Squamous Cell Carcinomas of the Skin; Their Relationship with Tumor Invasiveness and Histological Subtype. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2116479&form=6&db=m Mechanisms underlying the anti-inflammatory effects of essential fatty acid deficiency in experimental glomerulonephritis. Inhibited release of a monocyte chemoattractant by glomeruli. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3222274&form=6&db=m Glomerular eicosanoid production in acute serum sickness nephritis. therapeutic application,unassigned 1,0
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9513902&form=6&db=m Expression and localization of cyclooxygenase isoforms and cytosolic phospholipase A2 in anti-Thy-1 glomerulonephritis. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10959556&form=6&db=m Upregulation of cyclooxygenase-1 and the PGE2 receptor EP2 in rat and human mesangioproliferative glomerulonephritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135071&form=6&db=m Hyaluronan-induced cyclooxygenase-2 expression promotes thromboxane A2 production by renal cells. ongoing research,unassigned 4,0
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14636300&form=6&db=m COX-2 inhibition and prostaglandin receptors in experimental nephritis. therapeutic application,unassigned 4,0
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15789535&form=6&db=m [Tubulointerstitial nephritis associated with treatment with selective Cox-2 inhibitors, celecoxib and rofecoxib] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16438990&form=6&db=m Anti-inflammatory action of dietary fish oil and calorie restriction. causal interaction,unassigned 2,0
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17202413&form=6&db=m Overexpression of cyclooxygenase-2 predisposes to podocyte injury. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Nephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17533010&form=6&db=m Roles of lipid mediators in kidney injury. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316248&form=6&db=m Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid. causal interaction,unassigned 3,0
1.14.99.1 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11425419&form=6&db=m Acute tubulointerstitial nephritis associated with the selective COX-2 enzyme inhibitor, rofecoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12046048&form=6&db=m Celecoxib-induced acute interstitial nephritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12608557&form=6&db=m Membranous glomerulopathy and acute interstitial nephritis following treatment with celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12886856&form=6&db=m Acute interstitial nephritis and COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4
1.14.99.1 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15789535&form=6&db=m [Tubulointerstitial nephritis associated with treatment with selective Cox-2 inhibitors, celecoxib and rofecoxib] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15909598&form=6&db=m Cyclooxygenase-2 inhibitor-associated minimal-change disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15909599&form=6&db=m COX-2 inhibitors and acute interstitial nephritis: case report and review of the literature. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Nephritis, Interstitial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28536229&form=6&db=m Cyclooxygenase-2 inhibitor-induced acute interstitial nephritis. causal interaction,unassigned 2,0
1.14.99.1 Nephrocalcinosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6418262&form=6&db=m Inhibition of experimental nephrocalcinosis with a prostaglandin synthetase inhibitor. therapeutic application,unassigned 4,0
1.14.99.1 Nephrocalcinosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21431899&form=6&db=m A novel compound heterozygous ROMK mutation presenting as late onset Bartter syndrome associated with nephrocalcinosis and elevated 1,25(OH)(2) vitamin D levels. therapeutic application,unassigned 4,0
1.14.99.1 Nephrolithiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23662491&form=6&db=m [The effectiveness of certain magnesium salts in nephrolithiasis caused by the use of sodium oxalate and celecoxib]. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Nephrolithiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24000715&form=6&db=m [Experimental evidence of magnesium salts for treatment of calcium oxalate nephrolithiasis in an animal model based on sodium oxalate and a cyclooxygenase 2 selective inhibitor]. therapeutic application,unassigned 4,0
1.14.99.1 Nephrosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19246637&form=6&db=m Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R. unassigned -
1.14.99.1 Nephrosis, Lipoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15909598&form=6&db=m Cyclooxygenase-2 inhibitor-associated minimal-change disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12407655&form=6&db=m Nephrotic syndrome and interstitial nephritis associated with celecoxib. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15909598&form=6&db=m Cyclooxygenase-2 inhibitor-associated minimal-change disease. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22129825&form=6&db=m Profound urinary protein loss and acute renal failure caused by cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29187369&form=6&db=m Pharmacological and Genetic Inhibition of Downstream Targets of p38 MAPK in Experimental Nephrotic Syndrome. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Nephrotic Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31416888&form=6&db=m Risk of Nephrotic Syndrome for Non-Steroidal Anti-Inflammatory Drug Users. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Nerve Compression Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15611304&form=6&db=m Clinical Vignette. Sciatic nerve entrapment secondary to heterotopic ossification: imaging findings and potential effect of selective cox-2 inhibitors. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10869693&form=6&db=m A novel gliotic P2 receptor mediating cyclooxygenase-2 induction in rat and human astrocytes. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15331118&form=6&db=m Mechanism of age-associated up-regulation in macrophage PGE2 synthesis. causal interaction,unassigned 4,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17073683&form=6&db=m Imaging of cyclooxygenase-2 (COX-2) expression: potential use in diagnosis and drug evaluation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17521299&form=6&db=m Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537667&form=6&db=m Cyclooxygenase-2 in synaptic signaling. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20847443&form=6&db=m Amyloid-? Induces Cyclooxygenase-2 and PGE2 Release in Human Astrocytes in NF-? B Dependent Manner. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21417030&form=6&db=m [COX-2 regulation of prostaglandins in synaptic signaling]. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807121&form=6&db=m Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396759&form=6&db=m In vivo evaluation of [11C]TMI, a COX-2 selective PET tracer, in baboons. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33828386&form=6&db=m Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor. causal interaction,unassigned 3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10842019&form=6&db=m Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516414&form=6&db=m A stable prostacyclin analog enhances ectopic activity in rat sensory neurons following neuropathic injury. therapeutic application,unassigned 2,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204486&form=6&db=m The impact of pain management on quality of life. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12708559&form=6&db=m Interventions in chronic pain management. 4. Medications in pain management. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14506908&form=6&db=m High-throughput proteomics and protein biomarker discovery in an experimental model of inflammatory hyperalgesia: effects of nimesulide. unassigned -
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576556&form=6&db=m Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14746896&form=6&db=m Peri-sciatic administration of indomethacin early after nerve injury can attenuate the development of tactile allodynia in a rat model of L5 single spinal nerve injury. ongoing research,unassigned 4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026129&form=6&db=m Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15126127&form=6&db=m Effect of etodolac, a COX-2 inhibitor, on neuropathic pain in a rat model. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15182944&form=6&db=m Cyclooxygenase-2 expression in Schwann cells and macrophages in the sciatic nerve after single spinal nerve injury in rats. causal interaction,unassigned 4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501312&form=6&db=m Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15572651&form=6&db=m The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16032587&form=6&db=m Systemic meloxicam reduces tactile allodynia development after L5 single spinal nerve injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16192777&form=6&db=m Role for cyclooxygenase 2 in the development and maintenance of neuropathic pain and spinal glial activation. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16920373&form=6&db=m Ameliorative effect of combined administration of inducible nitric oxide synthase inhibitor with cyclooxygenase-2 inhibitors in neuropathic pain in rats. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17055166&form=6&db=m GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17112505&form=6&db=m Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606213&form=6&db=m Electroacupuncture inhibits cyclooxygenase-2 up-regulation in rat spinal cord after spinal nerve ligation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19346674&form=6&db=m Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19498273&form=6&db=m Demonstration of antiallodynic effects of the cyclooxygenase-2 inhibitor meloxicam on established diabetic neuropathic pain in mice. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19594750&form=6&db=m NCX 2057, a novel NO-releasing derivative of ferulic acid, suppresses inflammatory and nociceptive responses in in vitro and in vivo models. ongoing research,unassigned 3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19663884&form=6&db=m Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats. ongoing research,unassigned 2,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19815945&form=6&db=m Bradykinin receptor antagonists and cyclooxygenase inhibitors in vincristine- and streptozotocin-induced hyperalgesia. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20654703&form=6&db=m Electroacupuncture versus celecoxib for neuropathic pain in rat SNL model. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21073910&form=6&db=m Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293 cells and rat brain tissue. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21371033&form=6&db=m Role of prostaglandin E2 in the synthesis of the pro-inflammatory cytokine interleukin-6 in primary sensory neurons: an in vivo and in vitro study. causal interaction,unassigned 3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21996269&form=6&db=m The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22053353&form=6&db=m (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. therapeutic application,unassigned 2,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22221687&form=6&db=m Biphasic effects of chronic intrathecal gabapentin administration on the expression of protein kinase C gamma in the spinal cord of neuropathic pain rats. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22739568&form=6&db=m Etodolac Blocks the Allyl Isothiocyanate-Induced Response in Mouse Sensory Neurons by Selective TRPA1 Activation. therapeutic application,unassigned 4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23899306&form=6&db=m Cellular sources of cyclooxygenase-1 and -2 up-regulation in the spinal dorsal horn after spinal nerve ligation. causal interaction,unassigned 4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23908078&form=6&db=m [Changes in expression of cyclooxygenase-2 in the spinal dorsal horn after intrathecal p38MAPK inhibitor SB203580 on neuropathic pain in rats]. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23929706&form=6&db=m Progesterone reduces the expression of spinal cyclooxygenase-2 and inducible nitric oxide synthase and prevents allodynia in a rat model of central neuropathic pain. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24603592&form=6&db=m Curcumin Alleviates Neuropathic Pain by Inhibiting p300/CBP Histone Acetyltransferase Activity-Regulated Expression of BDNF and Cox-2 in a Rat Model. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25031810&form=6&db=m The Attenuation of Pain Behavior and Serum COX-2 Concentration by Curcumin in a Rat Model of Neuropathic Pain. ongoing research,unassigned 4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25842094&form=6&db=m Changes in expression of cyclooxygenase-2 in the spinal dorsal horn after intrathecal p38MAPK inhibitor SB203580 on neuropathic pain in rats. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26546510&form=6&db=m Celecoxib reverts oxaliplatin-induced neuropathic pain through inhibiting PI3K/Akt2 pathway in the mouse dorsal root ganglion. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27778263&form=6&db=m Effects of electroacupuncture intervention on expression of cyclooxygenase 2 and microglia in spinal cord in rat model of neuropathic pain. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27821910&form=6&db=m Celecoxib alleviates oxaliplatin-induced hyperalgesia through inhibition of spinal ERK1/2 signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28685867&form=6&db=m MiR-150 alleviates neuropathic pain via inhibiting toll-like receptor 5. causal interaction,unassigned 1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28849589&form=6&db=m ?-Spinasterol: a cyclooxygenase inhibitor and a TRPV1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30058089&form=6&db=m MiR-28-5p relieves neuropathic pain by targeting Zeb1 in CCI rat models. unassigned -
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30066874&form=6&db=m MicroRNA?143?3p contributes to the regulation of pain responses in collagen?induced arthritis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31306980&form=6&db=m Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31602666&form=6&db=m Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31930555&form=6&db=m miR-194 relieve neuropathic pain and prevent neuroinflammation via targeting FOXA1. therapeutic application,unassigned 2,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32098588&form=6&db=m miR-384-5p ameliorates neuropathic pain by targeting SCN3A in a rat model of chronic constriction injury. therapeutic application,unassigned 2,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33239680&form=6&db=m Thymus algeriensis and Thymus fontanesii exert neuroprotective effect against chronic constriction injury-induced neuropathic pain in rats. ongoing research,unassigned 4,0
1.14.99.1 Neuralgia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34279369&form=6&db=m The Role of Organic Small Molecules in Pain Management. therapeutic application,unassigned 4,0
1.14.99.1 Neuralgia, Postherpetic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19409858&form=6&db=m A Randomized, Double-Blind, Placebo-Controlled Trial of a Selective COX-2 Inhibitor, GW406381, in Patients With Postherpetic Neuralgia. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18998056&form=6&db=m Expression of HIF-1, galectin-3, cox-2 and Wilms tumor-1 protein in multiple schwannomas of the conus medullaris. unassigned -
1.14.99.1 Neurilemmoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291992&form=6&db=m COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694223&form=6&db=m The effect of cyclooxygenase-2 inhibitor on experimental allergic neuritis. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10377818&form=6&db=m [Immunopathology of inflammatory neuropathies] diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567084&form=6&db=m The action mechanism of cyclooxygenase-2 inhibitor for treatment of experimental allergic neuritis. therapeutic application,unassigned 4,0
1.14.99.1 Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11870698&form=6&db=m New cyclooxygenase-2 inhibitors for treatment of experimental autoimmune neuritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12916703&form=6&db=m Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Neuritis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9694223&form=6&db=m The effect of cyclooxygenase-2 inhibitor on experimental allergic neuritis. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuritis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10377818&form=6&db=m [Immunopathology of inflammatory neuropathies] diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Neuritis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10567084&form=6&db=m The action mechanism of cyclooxygenase-2 inhibitor for treatment of experimental allergic neuritis. therapeutic application,unassigned 4,0
1.14.99.1 Neuritis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11870698&form=6&db=m New cyclooxygenase-2 inhibitors for treatment of experimental autoimmune neuritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuritis, Autoimmune, Experimental http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12916703&form=6&db=m Involvement of cyclooxygenase-1 and -2 in the sciatic nerve of rats with experimental autoimmune neuritis. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3917850&form=6&db=m Inhibition of human malignant neuroblastoma cell DNA synthesis by lipoxygenase metabolites of arachidonic acid. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6406922&form=6&db=m Conversion of arachidonic acid to cyclooxygenase and lipoxygenase products, and incorporation into phospholipids in the mouse neuroblastoma clone, Neuro-2A. ongoing research,unassigned 3,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8581564&form=6&db=m Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase. ongoing research,unassigned 3,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726429&form=6&db=m Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9740394&form=6&db=m Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032891&form=6&db=m Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181073&form=6&db=m Cyclooxygenase-2 stimulates production of amyloid beta-peptide in neuroblastoma x glioma hybrid NG108-15 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11250126&form=6&db=m Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11299304&form=6&db=m Up-regulation of cyclooxygenase-1 in neuroblastoma cell lines by retinoic acid and corticosteroids. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070143&form=6&db=m Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. therapeutic application,unassigned 1,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12395095&form=6&db=m Cyclo-oxygenase inhibitors protect against prion-induced neurotoxicity in vitro. therapeutic application,unassigned 3,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12466023&form=6&db=m Cyclooxygenase-2 is a neuronal target gene of NF-kappaB. unassigned -
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12628757&form=6&db=m Caspase-1 inhibitors abolish deleterious enhancement of COX-2 expression induced by HIV-1 gp120 in human neuroblastoma cells. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15241564&form=6&db=m The oral administration of retinoic acid enhances nociceptive withdrawal reflexes in rats with soft-tissue inflammation. ongoing research,unassigned 4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492235&form=6&db=m Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15690129&form=6&db=m Inhibition of human neuroblastoma cell growth by CAY10404, a highly selective Cox-2 inhibitor. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15950779&form=6&db=m Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: a comparative study of human neuroglioma and neuroblastoma cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15975708&form=6&db=m NSAIDs in neuroblastoma therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16001969&form=6&db=m Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552621&form=6&db=m Inhibition of human neuroblastoma in SCID mice by low-dose of selective Cox-2 inhibitor nimesulide. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16983334&form=6&db=m Cyclooxygenase inhibitors modulate the p53/HDM2 pathway and enhance chemotherapy-induced apoptosis in neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17204142&form=6&db=m All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17289900&form=6&db=m Celecoxib prevents neuroblastoma tumor development and potentiates the effect of chemotherapeutic drugs in vitro and in vivo. ongoing research,unassigned 4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18485347&form=6&db=m Upregulation of DSCR1 (RCAN1 or Adapt78) in the peri-infarct cortex after experimental stroke. unassigned -
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19118018&form=6&db=m Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. unassigned -
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19363520&form=6&db=m Cyclooxygenase inhibitors differentially modulate p73 isoforms in neuroblastoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19673886&form=6&db=m Prolonged low-dose administration of the cyclooxygenase-2 inhibitor celecoxib enhances the antitumor activity of irinotecan against neuroblastoma xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19751497&form=6&db=m Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. ongoing research,unassigned 2,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20851755&form=6&db=m Paraquat induces cyclooxygenase-2 (COX-2) implicated toxicity in human neuroblastoma SH-SY5Y cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21104853&form=6&db=m Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: Role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway. unassigned -
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268077&form=6&db=m Enterovirus 71 modulates a COX-2/PGE2/cAMP-dependent viral replication in human neuroblastoma cells: role of the c-Src/EGFR/p42/p44 MAPK/CREB signaling pathway. unassigned -
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22127347&form=6&db=m Enhanced antitumor effect of lower-dose and longer-term CPT-11 treatment in combination with low-dose celecoxib against neuroblastoma xenografts. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22276108&form=6&db=m Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22617635&form=6&db=m Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model. therapeutic application,unassigned 4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23416140&form=6&db=m JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis. ongoing research,unassigned 4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24621265&form=6&db=m Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1? and A? between glial and neuron cells. ongoing research,unassigned 4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25266063&form=6&db=m Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via ?-catenin stabilization. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26909300&form=6&db=m The SK-N-AS human neuroblastoma cell line develops osteolytic bone metastases with increased angiogenesis and COX-2 expression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27348899&form=6&db=m The Sarin-like Organophosphorus Agent bis (isopropyl methyl)phosphonate Induces Apoptotic Cell Death and COX-2 Expression in SK-N-SH Cells. ongoing research,unassigned 4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27598175&form=6&db=m A Coral-Derived Compound Improves Functional Recovery after Spinal Cord Injury through Its Antiapoptotic and Anti-Inflammatory Effects. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28671636&form=6&db=m Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-?B/TNF-? Signaling. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29498006&form=6&db=m Inhibition of Cyclooxygenase-2 (COX-2) Initiates Autophagy and Potentiates MPTP-Induced Autophagic Cell Death of Human Neuroblastoma Cells, SH-SY5Y: an Inside in the Pathology of Parkinson's Disease. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29944913&form=6&db=m Methamphetamine toxicity-induced calcineurin activation, nuclear translocation of nuclear factor of activated T-cells and elevation of cyclooxygenase 2 levels are averted by calpastatin overexpression in neuroblastoma SH-SY5Y cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30471009&form=6&db=m Mild Hypothermia Prevents NO-Induced Cytotoxicity in Human Neuroblastoma Cells Via Induction of COX-2. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30766660&form=6&db=m Zinc Oxide Nanoparticles Exhibit Both Cyclooxygenase- and Lipoxygenase-Mediated Apoptosis in Human Bone Marrow-Derived Mesenchymal Stem Cells. ongoing research,unassigned 4,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30883354&form=6&db=m Cyclooxygenase-2 is Essential for Mediating the Effects of Calcium Ions on Stimulating Phosphorylation of Tau at the Sites of Ser 396 and Ser 404. ongoing research,unassigned 2,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32181114&form=6&db=m Neuroblastoma SH-SY5Y cytotoxicity, anti-amyloidogenic activity and cyclooxygenase inhibition of Lasianthus trichophlebus (Rubiaceae). unassigned -
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32865065&form=6&db=m Antioxidant effect of acetyl-l-carnitine against cisplatin-induced cardiotoxicity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33134292&form=6&db=m Celecoxib Exerts Neuroprotective Effects in ?-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9726429&form=6&db=m Strong nuclear factor-kappaB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10652449&form=6&db=m Cyclooxygenase-2 is highly expressed in microglial-like cells in a murine model of prion disease. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10869693&form=6&db=m A novel gliotic P2 receptor mediating cyclooxygenase-2 induction in rat and human astrocytes. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11203433&form=6&db=m Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders. therapeutic application,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11250126&form=6&db=m Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11462804&form=6&db=m Modulation of cyclooxygenase-2 and brain reactive astrogliosis by purinergic P2 receptors. causal interaction,unassigned 3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11792368&form=6&db=m Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12472883&form=6&db=m Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12672447&form=6&db=m Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation. unassigned -
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561325&form=6&db=m Inflammation in central nervous system injury. causal interaction,unassigned 3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15122707&form=6&db=m Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. causal interaction,unassigned 2,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15331118&form=6&db=m Mechanism of age-associated up-regulation in macrophage PGE2 synthesis. causal interaction,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15588680&form=6&db=m Zingansikpoongtang modulates beta-amyloid and IL-1beta-induced cytokine production and cyclooxygenase-2 expression in human astrocytoma cells U373MG. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15681959&form=6&db=m Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944180&form=6&db=m Levels of CSF prostaglandin E2, cognitive decline, and survival in Alzheimer's disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15975667&form=6&db=m Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16277613&form=6&db=m Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522321&form=6&db=m Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice. causal interaction,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16604526&form=6&db=m Transgenic mouse for conditional, tissue-specific Cox-2 overexpression. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16671960&form=6&db=m Effect of rofecoxib, a cyclo-oxygenase-2 inhibitor, on various biochemical parameters of brain associated with pentylenetetrazol-induced chemical kindling in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16892400&form=6&db=m Detection of Overexpressed COX-2 in Precancerous Lesions of Hamster Pancreas and Lungs by Molecular Imaging: Implications for Early Diagnosis and Prevention. causal interaction,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16989810&form=6&db=m Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression. causal interaction,unassigned 3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17027965&form=6&db=m Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17574754&form=6&db=m Divergent effects of prostaglandin receptor signaling on neuronal survival. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612048&form=6&db=m Role of COX-2 in inflammatory and degenerative brain diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18255268&form=6&db=m Cyclooxygenase-2/PGE(2) pathway facilitates pentylenetetrazol-induced seizures. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18389097&form=6&db=m Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537667&form=6&db=m Cyclooxygenase-2 in synaptic signaling. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18976930&form=6&db=m Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. causal interaction,unassigned 3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19090241&form=6&db=m Effects of aspirin and celecoxib on rigidity in a rat model of Parkinson's disease. therapeutic application,unassigned 1,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19269697&form=6&db=m The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19698752&form=6&db=m Cyclooxygenase-2 plays a critical role in retinal ganglion cell death after transient ischemia: Real-time monitoring of RGC survival using Thy-1-EGFP transgenic mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20043943&form=6&db=m Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192567&form=6&db=m Curcumin: from food spice to cancer prevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21417030&form=6&db=m [COX-2 regulation of prostaglandins in synaptic signaling]. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21439356&form=6&db=m Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat. causal interaction,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21680698&form=6&db=m In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester. causal interaction,unassigned 3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21694498&form=6&db=m Cyclooxygenase-1 is involved in the inhibition of hippocampal neurogenesis after lipopolysaccharide-induced neuroinflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001217&form=6&db=m Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22796600&form=6&db=m Celecoxib delays cognitive decline in an animal model of neurodegeneration. causal interaction,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22803672&form=6&db=m (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-?B? degradation in LPS-stimulated BV-2 microglial cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23142242&form=6&db=m Therapeutic potential of monoacylglycerol lipase inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059237&form=6&db=m Radiotracers for Molecular Imaging of Cyclooxygenase-2 (COX-2) Enzyme. causal interaction,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24279689&form=6&db=m Prostanoid Receptor EP2 as a Therapeutic Target. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24446952&form=6&db=m Cyclooxygenase-2 in epilepsy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25818189&form=6&db=m Monoacylglycerol lipase inhibitor protects primary cultured neurons against homocysteine-induced impairments in rat caudate nucleus through COX-2 signaling. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585055&form=6&db=m Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer's Disease Model Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27033056&form=6&db=m Misoprostol reverse hippocampal neuron cyclooxygenase-2 downstream signaling imbalance in aluminum-overload rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28232747&form=6&db=m In situ click chemistry generation of cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29234401&form=6&db=m causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663741&form=6&db=m Interactive involvement of hippocampal cAMP/PKA and cyclooxygenase-2 signaling pathways in spatial learning in the Morris water maze. causal interaction,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29756563&form=6&db=m Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968808&form=6&db=m Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor. unassigned -
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30203712&form=6&db=m Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO. unassigned -
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31598112&form=6&db=m Radiosynthesis and Preclinical Evaluation of 11C-VA426, a Cyclooxygenase-2 Selective Ligand. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31854058&form=6&db=m An Activity-Based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells. causal interaction,unassigned 4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33063743&form=6&db=m Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33172102&form=6&db=m Synthesis, 3D-QSAR, and Molecular Modeling Studies of Triazole Bearing Compounds as a Promising Scaffold for Cyclooxygenase-2 Inhibition. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33438260&form=6&db=m Exogenous ATP modulates PGE2 release in macrophages through sustained phosphorylation of CDK9 and p38 MAPK. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33619313&form=6&db=m Three-dimensional structure of human cyclooxygenase (hCOX)-1. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34089729&form=6&db=m Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neuroectodermal Tumors, Primitive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11911965&form=6&db=m Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxib. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Neuroectodermal Tumors, Primitive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34497154&form=6&db=m Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17540723&form=6&db=m Cox-2 promotes chromogranin A expression and bioactivity: evidence for a prostaglandin E2-dependent mechanism and the involvement of a proximal cyclic adenosine 5'-monophosphate-responsive element. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17629053&form=6&db=m Cyclooxygenase-2 expression in gastroenteropancreatic neuroendocrine tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4
1.14.99.1 Neuroendocrine Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22022296&form=6&db=m Clinical significance of protein expression of cyclooxygenase-2 and somatostatin receptors in gastroenteropancreatic neuroendocrine tumors. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Neurofibromatoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21221032&form=6&db=m Cyclooxygenase-2 supports tumor proliferation in vestibular schwannomas. causal interaction,unassigned 4,0
1.14.99.1 Neurofibromatoses http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291992&form=6&db=m COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neurofibromatosis 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21221032&form=6&db=m Cyclooxygenase-2 supports tumor proliferation in vestibular schwannomas. causal interaction,unassigned 4,0
1.14.99.1 Neurofibromatosis 2 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291992&form=6&db=m COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neurofibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19921253&form=6&db=m Establishment and characterization of a novel human malignant peripheral nerve sheath tumor cell line, FMS-1, that overexpresses epidermal growth factor receptor and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Neurofibrosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24516579&form=6&db=m Overexpression of cyclooxygenase-2 in malignant peripheral nerve sheath tumor and selective cyclooxygenase-2 inhibitor-induced apoptosis by activating caspases in human malignant peripheral nerve sheath tumor cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neurogenic Inflammation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8317315&form=6&db=m Cyclooxygenase inhibitors acetylsalicylic acid and indomethacin do not affect capsaicin-induced neurogenic inflammation in human skin. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neurogenic Inflammation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16492237&form=6&db=m Effects of Parecoxib on Plasma Protein Extravasation and c-Fos Expression in the Rat. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neurogenic Inflammation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25892078&form=6&db=m Role of phosphorylated extracellular signal-regulated kinase, calcitonin gene-related peptide and cyclooxygenase-2 in experimental rat models of migraine. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Neurogenic Inflammation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30528878&form=6&db=m Bradykinin and interleukin-1? synergistically increase the expression of cyclooxygenase-2 through the RNA-binding protein HuR in rat dorsal root ganglion cells. causal interaction,unassigned 4,0
1.14.99.1 Neurogenic Inflammation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33000580&form=6&db=m Efficacy of active compounds of Chanqin granules on airway neurogenic inflammation induced by PM2.5 in vivo. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11026726&form=6&db=m The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14731075&form=6&db=m Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain. therapeutic application,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15081582&form=6&db=m Neuroinflammation, COX-2, and ALS--a dual role? therapeutic application,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15850932&form=6&db=m Regulation of prostaglandin E2 synthesis after brain irradiation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15854773&form=6&db=m Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15920730&form=6&db=m Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16464474&form=6&db=m Lipoteichoic acid induces prostaglandin E(2) release and cyclooxygenase-2 synthesis in rat cortical neuronal cells: involvement of PKCepsilon and ERK activation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16600409&form=6&db=m Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17202128&form=6&db=m Altered brain lipid composition in cyclooxygenase-2 knockout mouse. causal interaction,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17539917&form=6&db=m COX-2 oxidative metabolite of endocannabinoid 2-AG enhances excitatory glutamatergic synaptic transmission and induces neurotoxicity. causal interaction,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17629358&form=6&db=m Roles of prostaglandin synthesis in excitotoxic brain diseases. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18383341&form=6&db=m Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537667&form=6&db=m Cyclooxygenase-2 in synaptic signaling. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18666748&form=6&db=m Nuclear imaging of inflammation in neurologic and psychiatric disorders. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19269697&form=6&db=m The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19487152&form=6&db=m [(11)C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease? ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025057&form=6&db=m Expression of cyclooxygenase-2 and microsomal prostaglandin-E synthase in amoeboid microglial cells in the developing brain and effects of cyclooxygenase-2 neutralization on BV-2 microglial cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20038958&form=6&db=m Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20157512&form=6&db=m Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20157521&form=6&db=m A role for cyclooxygenase-1 in beta-amyloid-induced neuroinflammation. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20549385&form=6&db=m Cyclooxygenase (COX)-1 Activity Precedes the COX-2 Induction in Abeta-Induced Neuroinflammation. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20693654&form=6&db=m Neuroinflammation in Alzheimer's Disease: Are NSAIDs and Selective COX-2 Inhibitors the Next Line of Therapy? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20714215&form=6&db=m Rethinking the role of cyclooxygenase-1 in neuroinflammation: more than homeostasis. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20808546&form=6&db=m Cyclooxygenase and neuroinflammation in Parkinson's disease neurodegeneration. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20868723&form=6&db=m Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21075851&form=6&db=m Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21106803&form=6&db=m Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21299906&form=6&db=m Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21417030&form=6&db=m [COX-2 regulation of prostaglandins in synaptic signaling]. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21504126&form=6&db=m Neuroinflammation in Alzheimer's disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21680698&form=6&db=m In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester. causal interaction,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21694498&form=6&db=m Cyclooxygenase-1 is involved in the inhibition of hippocampal neurogenesis after lipopolysaccharide-induced neuroinflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957234&form=6&db=m Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal cyclooxygenase-2 function, lipid peroxidation, and neuroprotection. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001217&form=6&db=m Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22142863&form=6&db=m Acute neuroinflammation and neurogenesis: a role for microglial COX-1. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22263894&form=6&db=m Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2'-Des-methyl-sulindac Sulfide Scaffold. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22523472&form=6&db=m Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22771072&form=6&db=m Cognitive effects of NSAIDs in cerebral ischemia: A hypothesis exploring mechanical action mediated pharmacotherapy. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22773310&form=6&db=m Targeting cyclooxygenase-2 in depression is not a viable therapeutic approach and may even aggravate the pathophysiology underpinning depression. causal interaction,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22780884&form=6&db=m Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22892161&form=6&db=m Potential of D-cycloserine in the treatment of behavioral and neuroinflammatory disorders in Parkinson's disease and studies that need to be performed before clinical trials. therapeutic application,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22959208&form=6&db=m The cyclooxygenase-2 inhibitor parecoxib inhibits surgery-induced proinflammatory cytokine expression in the hippocampus in aged rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23083210&form=6&db=m Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23132402&form=6&db=m Simultaneous inhibition of COX-2 and activation of PPAR-? resulted in the same level and pattern of neuroprotection as they were targeted separately. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23507189&form=6&db=m Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: Possible involvement of NF-?B and p38 MAPK inhibition. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23626659&form=6&db=m Splenic Immune Cells In Experimental Neonatal Hypoxia-Ischemia. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23685326&form=6&db=m Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23688860&form=6&db=m Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities. therapeutic application,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23709104&form=6&db=m Acetate reduces PGE2 release and modulates phospholipase and cyclooxygenase levels in neuroglia stimulated with lipopolysaccharide. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23893854&form=6&db=m CCAAT/Enhancer binding protein ? regulates prostaglandin E synthase expression and prostaglandin E2 production in activated microglial cells. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23916895&form=6&db=m Dysregulation in myelination mediated by persistent neuroinflammation: Possible mechanisms in chemotherapy-related cognitive impairment. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24349442&form=6&db=m A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation. ongoing research,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24355215&form=6&db=m Rapid and simultaneous quantitation of prostanoids by UPLC-MS/MS in rat brain. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24420785&form=6&db=m Amelioration of Diabetes-induced Cognitive Deficits by GSK-3? Inhibition is Attributed to Modulation of Neurotransmitters and Neuroinflammation. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24814703&form=6&db=m Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction. causal interaction,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25374508&form=6&db=m Valproic acid potentiates curcumin-mediated neuroprotection in lipopolysaccharide induced rats. diagnostic usage,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25489058&form=6&db=m Brain-targeted Angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25621771&form=6&db=m FLZ attenuates learning and memory deficits via suppressing neuroinflammation induced by LPS in mice. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701797&form=6&db=m Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25869103&form=6&db=m Hypertension exacerbates predisposition to neurodegeneration and memory impairment in the presence of a neuroinflammatory stimulus: Protection by angiotensin converting enzyme inhibition. ongoing research,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26209154&form=6&db=m Caffeine prevents d-galactose-induced cognitive deficits, oxidative stress, neuroinflammation and neurodegeneration in the adult rat brain. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26209559&form=6&db=m Endogenous 2-Arachidonoylglycerol Alleviates Cyclooxygenases-2 Elevation-Mediated Neuronal Injury From SO2 Inhalation via PPAR? Pathway. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26511468&form=6&db=m Update on SAR Studies Toward New COX-1 Selective Inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26585055&form=6&db=m Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer's Disease Model Mice. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26608623&form=6&db=m Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26781425&form=6&db=m COX-1 and COX-2 polymorphisms in susceptibility to cerebral palsy in very preterm infants. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26808646&form=6&db=m Hazelnut and neuroprotection: Improved memory and hindered anxiety in response to intra-hippocampal A? injection. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26857505&form=6&db=m Role of cox-2 mediated neuroinflammation on the neurodegeneration and cognitive impairments in colchicine induced rat model of Alzheimer's Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26880859&form=6&db=m Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26963472&form=6&db=m Centrally Synthesized Estradiol is a Potent Anti-Inflammatory in the Injured Zebra Finch Brain. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27058626&form=6&db=m Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27062228&form=6&db=m Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside. causal interaction,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27087648&form=6&db=m Trans-Cinnamaldehyde, An Essential Oil in Cinnamon Powder, Ameliorates Cerebral Ischemia-Induced Brain Injury via Inhibition of Neuroinflammation Through Attenuation of iNOS, COX-2 Expression and NF?-B Signaling Pathway. therapeutic application,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27106205&form=6&db=m Modulation of LOX and COX pathways via inhibition of amyloidogenesis contributes to mitoprotection against ?-amyloid oligomer-induced toxicity in an animal model of Alzheimer's disease in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27111555&form=6&db=m COX-1 Inhibitors: Beyond Structure Toward Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27117003&form=6&db=m The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. therapeutic application,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27258396&form=6&db=m Attenuated SIV causes persisting neuroinflammation in the absence of a chronic viral load and neurotoxic ART. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27616549&form=6&db=m Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: In vivo and in vitro evidence. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27665568&form=6&db=m Dual Role of Vitamin C on the Neuroinflammation Mediated Neurodegeneration and Memory Impairments in Colchicine Induced Rat Model of Alzheimer Disease. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27667770&form=6&db=m Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27790086&form=6&db=m Traumatic Brain Injury Leads to Development of Parkinson's Disease Related Pathology in Mice. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28063173&form=6&db=m Identification of highly connected hub genes in the protective response program of human macrophages and microglia activated by alpha B-crystallin. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28189744&form=6&db=m Krüppel-like factor 4 regulates amyloid-? (A?)-induced neuroinflammation in Alzheimer's disease. therapeutic application,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28215000&form=6&db=m Angiotensin II Receptor Blockers Attenuate Lipopolysaccharide-Induced Memory Impairment by Modulation of NF-?B-Mediated BDNF/CREB Expression and Apoptosis in Spontaneously Hypertensive Rats. causal interaction,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28222524&form=6&db=m A Combination of Resveratrol and Curcumin is Effective Against Aluminum Chloride-Induced Neuroinflammation in Rats. diagnostic usage,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28393111&form=6&db=m The Cox-2 Inhibitor Meloxicam Ameliorates Neuroinflammation and Depressive Behavior in Adult Mice after Splenectomy. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28405903&form=6&db=m Stress-Induced Alterations of Immune Profile in Animals Suffering by Tau Protein-Driven Neurodegeneration. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28474563&form=6&db=m Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28485773&form=6&db=m Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28526927&form=6&db=m Sodium thiosulphate attenuates brain inflammation induced by systemic lipopolysaccharide administration in C57BL/6J mice. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28649222&form=6&db=m Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28651968&form=6&db=m Sodium P-aminosalicylic acid inhibits sub-chronic manganese-induced neuroinflammation in rats by modulating MAPK and COX-2. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28677372&form=6&db=m Early increased density of cyclooxygenase-2 (COX-2) immunoreactive neurons in Down syndrome. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28914791&form=6&db=m Quercetin Attenuates Manganese-Induced Neuroinflammation by Alleviating Oxidative Stress through Regulation of Apoptosis, iNOS/NF-?B and HO-1/Nrf2 Pathways. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28933223&form=6&db=m Genetic and Histological Alterations Reveal Key Role of Prostaglandin Synthase and Cyclooxygenase 1 and 2 in Traumatic Brain Injury-Induced Neuroinflammation in the Cerebral Cortex of Rats Exposed to Moderate Fluid Percussion Injury. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29032033&form=6&db=m Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier. therapeutic application,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29049070&form=6&db=m Noninfectious Fever in the Near-Term Pregnant Rat Induces Fetal Brain Inflammation: A Model for the Consequences of Epidural-Associated Maternal Fever. diagnostic usage,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29136779&form=6&db=m Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson's disease and cell culture via inactivating TLR4/NF-?B pathway. ongoing research,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29234401&form=6&db=m causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29306052&form=6&db=m Celecoxib Prevents Cognitive Impairment and Neuroinflammation in Soluble Amyloid ?-treated Rats. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29323698&form=6&db=m XIST accelerates neuropathic pain progression through regulation of miR-150 and ZEB1 in CCI rat models. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29348729&form=6&db=m causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29385149&form=6&db=m Erythropoietin attenuates motor neuron programmed cell death in a burn animal model. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29427085&form=6&db=m Regulatory Effects of Neuroinflammatory Responses Through Brain-Derived Neurotrophic Factor Signaling in Microglial Cells. causal interaction,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29495967&form=6&db=m Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy. therapeutic application,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29569150&form=6&db=m Impaired lipid metabolism markers to assess the risk of neuroinflammation in autism spectrum disorder. diagnostic usage,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663741&form=6&db=m Interactive involvement of hippocampal cAMP/PKA and cyclooxygenase-2 signaling pathways in spatial learning in the Morris water maze. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29678105&form=6&db=m 3-Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 1: Synthesis and Pharmacology. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29790749&form=6&db=m Anti-inflammatory Activity of 8-Hydroxydaidzein in LPS-Stimulated BV2 Microglial Cells via Activation of Nrf2-Antioxidant and Attenuation of Akt/NF-?B-Inflammatory Signaling Pathways, as Well As Inhibition of COX-2 Activity. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29792035&form=6&db=m 3-Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [11C]PS13 for Quantitative Imaging. diagnostic usage,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29792878&form=6&db=m Deoxyelephantopin ameliorates lipopolysaccharides (LPS)-induced memory impairments in rats: Evidence for its anti-neuroinflammatory properties. therapeutic application,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29800798&form=6&db=m Impact of structural alterations on the radiopharmacological profile of 18F-labeled pyrimidines as cyclooxygenase-2 (COX-2) imaging agents. causal interaction,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29879605&form=6&db=m Sub-chronic celecoxib prevents soluble beta amyloid-induced depressive-like behaviour in rats. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30020833&form=6&db=m Integrated communications between cyclooxygenase-2 and Alzheimer's disease. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30049816&form=6&db=m RGS10 Regulates the Expression of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha through a G Protein-Independent Mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30195730&form=6&db=m Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30203712&form=6&db=m Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30236122&form=6&db=m Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30445417&form=6&db=m (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30484341&form=6&db=m The COX-2/prostanoid signaling cascades in seizure disorders. causal interaction,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30488803&form=6&db=m Molecular Mechanisms of Curcumin in Neuroinflammatory Disorders: A Mini Review of Current Evidences. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502652&form=6&db=m Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPAR?/Nrf2/NF-?B signaling pathway. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30506300&form=6&db=m Expression of mGlu Receptor Genes in the Hippocampus After Intoxication with Trimethyltin. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30521407&form=6&db=m An update of cyclooxygenase (COX)-inhibitors in epilepsy disorders. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30529726&form=6&db=m inPentasomes: An innovative nose-to-brain pentamidine delivery blunts MPTP parkinsonism in mice. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30625493&form=6&db=m Anti-Inflammatory Effect of Lycopene on Experimental Spinal Cord Ischemia Injury via Cyclooxygenase-2 Suppression. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30740678&form=6&db=m Suppression of MALAT1 ameliorates chronic constriction injury-induced neuropathic pain in rats via modulating miR-206 and ZEB2. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30771604&form=6&db=m Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase. therapeutic application,unassigned 3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31112950&form=6&db=m Neonatal Inhibition of Connexin 36 Ameliorates Fetal Brain Injury Induced by Maternal Noninfectious Fever in Mice. diagnostic usage,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31202863&form=6&db=m Haplotypes of coping behavior associated QTL regions reveal distinct transcript profiles in amygdala and hippocampus. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31213669&form=6&db=m 6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31251974&form=6&db=m Monoacylglycerol lipase blockade impairs fine motor coordination and triggers cerebellar neuroinflammation through cyclooxygenase-2. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31345147&form=6&db=m Long non-coding RNA MALAT1 Inhibits Neuron Apoptosis and Neuroinflammation while Stimulates Neurite Outgrowth and its Correlation with MiR-125b Mediated PTGS2, CDK5 and FOXQ1 in Alzheimer's Disease. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666079&form=6&db=m Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734263&form=6&db=m Neuroinflammation induced by lipopolysaccharide leads to memory impairment and alterations in hippocampal leptin signaling. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31930555&form=6&db=m miR-194 relieve neuropathic pain and prevent neuroinflammation via targeting FOXA1. therapeutic application,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31936383&form=6&db=m Benzimidazole Containing Acetamide Derivatives Attenuate Neuroinflammation and Oxidative Stress in Ethanol-Induced Neurodegeneration. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32087283&form=6&db=m Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32359360&form=6&db=m PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32399622&form=6&db=m First-in-human evaluation of [11C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain. therapeutic application,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32485218&form=6&db=m Metabolic syndrome exacerbates amyloid pathology in a comorbid Alzheimer's mouse model. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32540418&form=6&db=m Inhibition of NK1R attenuates LPS-induced microglial inflammation and consequent death of PC12 cells. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32545964&form=6&db=m Gadolinium-Based Neuroprognostic Magnetic Resonance Imaging Agents Suppress COX-2 for Prevention of Reperfusion Injury after Stroke. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32632914&form=6&db=m Radiosynthesis and evaluation of [18F]FMTP, a COX-2 PET ligand. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32679284&form=6&db=m Protective effects of protocatechuic acid against cognitive impairment in an amyloid beta-induced Alzheimer's disease mouse model. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32702600&form=6&db=m COX-2-PGE2 signaling pathway contributes to hippocampal neuronal injury and cognitive impairment in PTZ-kindled epilepsy mice. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32803646&form=6&db=m Different Activation of IL-10 in the Hippocampus and Prefrontal Cortex During Neurodegeneration Caused by Trimethyltin Chloride. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32860157&form=6&db=m The Role of Brain Cyclooxygenase-2 (Cox-2) Beyond Neuroinflammation: Neuronal Homeostasis in Memory and Anxiety. causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32860901&form=6&db=m Circ_0005075 targeting miR-151a-3p promotes neuropathic pain in CCI rats via inducing NOTCH2 expression. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32978284&form=6&db=m Repurposing [11C]PS13 for PET imaging of cyclooxygenase-1 (COX-1) in ovarian cancer xenograft mouse models. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050589&form=6&db=m Synergic Therapeutic Potential of PEA-Um Treatment and NAAA Enzyme Silencing In the Management of Neuroinflammation. causal interaction,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33053754&form=6&db=m Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in A?1-42-Induced Mice. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059704&form=6&db=m Cyclooxygenase-1 mediates neuroinflammation and neurotoxicity in a mouse model of retinitis pigmentosa. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33312340&form=6&db=m Matcha Improves Metabolic Imbalance-Induced Cognitive Dysfunction. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33534108&form=6&db=m Repurposing of Tetracyclines for COVID-19 Neurological and Neuropsychiatric Manifestations: A Valid Option to Control SARS-CoV-2-Associated Neuroinflammation? unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33962540&form=6&db=m Virgin Coconut Oil-Induced Neuroprotection in Lipopolysaccharide-Challenged Rats is Mediated, in Part, Through Cholinergic, Anti-Oxidative and Anti-Inflammatory Pathways. causal interaction,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33982485&form=6&db=m [Screening of key genes and pathways of ischemic stroke and prediction of traditional Chinese medicines based on bioinformatics]. therapeutic application,unassigned 1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34118718&form=6&db=m Design, synthesis, and biological evaluation of furosemide analogs as therapeutics for the proteopathy and immunopathy of Alzheimer's disease. ongoing research,unassigned 2,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34267346&form=6&db=m Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34302237&form=6&db=m Amyloidogenic, neuroinflammatory and memory dysfunction effects of HIV-1 gp120. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34319540&form=6&db=m NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34346520&form=6&db=m Is cyclooxygenase-1 involved in neuroinflammation? causal interaction,unassigned 4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34364303&form=6&db=m Nilotinib inhibits microglia-mediated neuroinflammation to protect against dopaminergic neuronal death in Parkinson's disease models. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34381308&form=6&db=m Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products. unassigned -
1.14.99.1 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34494312&form=6&db=m Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-?B pathway in presenilin 1/2 conditional double knockout mice. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Neurologic Manifestations http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12505683&form=6&db=m Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Neuroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16393343&form=6&db=m Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Neuroma, Acoustic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21221032&form=6&db=m Cyclooxygenase-2 supports tumor proliferation in vestibular schwannomas. causal interaction,unassigned 4,0
1.14.99.1 Neuroma, Acoustic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31291992&form=6&db=m COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115069&form=6&db=m Endotoxin pretreatment enhances neutrophil FMLP-receptor binding and activity in guinea pigs. causal interaction,unassigned 3,0
1.14.99.1 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3115110&form=6&db=m C5a-induced hemodynamic and hematologic changes in the rabbit. Role of cyclooxygenase products and polymorphonuclear leukocytes. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Neutropenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12967936&form=6&db=m Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Nevi and Melanomas http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26608958&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 (COX-2) in oral nevi and melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11196178&form=6&db=m Expression of cyclooxygenase 2 in human malignant melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688483&form=6&db=m Analysis of cyclooxygenase 2 (COX-2) expression during malignant melanoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18537861&form=6&db=m Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma during malignant melanoma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038018&form=6&db=m Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24052986&form=6&db=m [Evaluation of COX-2 protein expression in melanocytic nevi in children]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26608958&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 (COX-2) in oral nevi and melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31528165&form=6&db=m Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31675116&form=6&db=m Immunohistochemical detectability of cyclooxygenase-2 expression in cells of human melanocytic skin lesions: A methodological review. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Nevus, Pigmented http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17499752&form=6&db=m Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Nevus, Pigmented http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24052986&form=6&db=m [Evaluation of COX-2 protein expression in melanocytic nevi in children]. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Newcastle Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508794&form=6&db=m Cyclooxygenase-2 Facilitates Newcastle Disease Virus Proliferation and Is as a Target for Canthin-6-One Antiviral Activity. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Nocturnal Enuresis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9503541&form=6&db=m [Nocturnal enuresis as a manifestation of autocoidosis] causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18423164&form=6&db=m [An experimental study on the expression and pathogenic effects of cyclooxygenase-2 in nonalcoholic fatty liver disease] ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19250220&form=6&db=m Cyclooxygenase-2 expression in chronic liver diseases and hepatocellular carcinoma: an immunohistochemical study . causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19609863&form=6&db=m Voluntary oral feeding of rats not requiring a very high fat diet is a clinically relevant animal model of non-alcoholic fatty liver disease (NAFLD). diagnostic usage,unassigned 4,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226139&form=6&db=m [Pathogenesis and treatment of non-alcoholic fatty liver disease.] unassigned -
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20929443&form=6&db=m Enhanced expression of pro-inflammatory mediators and liver X receptor-regulated lipogenic genes in nonalcoholic fatty liver disease and hepatitits C. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21059296&form=6&db=m [Relationship between single nucleotide polymorphisms in the promoter of COX-2 gene and hereditariness to NAFLD]. ongoing research,unassigned 4,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23975340&form=6&db=m Cyclooxygenase-2 Promotes Hepatocellular Apoptosis by Interacting with TNF-? and IL-6 in the Pathogenesis of Nonalcoholic Steatohepatitis in Rats. causal interaction,unassigned 1,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25453513&form=6&db=m Green Tea Lowers Hepatic COX-2 and Prostaglandin E2 in Rats with Dietary Fat-Induced Nonalcoholic Steatohepatitis. ongoing research,unassigned 1,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875942&form=6&db=m LPSF/GQ-02 inhibits the development of hepatic steatosis and inflammation in a mouse model of non-alcoholic fatty liver disease (NAFLD). therapeutic application,unassigned 1,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26723251&form=6&db=m Suppressing Cyclooxygenase-2 Prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27227672&form=6&db=m Contribution of Cyclooxygenase End Products and Oxidative Stress to Intrahepatic Endothelial Dysfunction in Early Non-Alcoholic Fatty Liver Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27431935&form=6&db=m Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor ?. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28187366&form=6&db=m A combination of dietary N-3 fatty acids and a cyclooxygenase-1 inhibitor attenuates nonalcoholic fatty liver disease in mice. therapeutic application,unassigned 4,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28871698&form=6&db=m [Effect of total flavones of hawthorn leafonon expression of COX-2/Nrf2 in liver of rats with nonalcoholic steatohepatitis]. diagnostic usage,unassigned 1,0
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29771124&form=6&db=m Genistein Ameliorates Non-alcoholic Fatty Liver Disease by Targeting the Thromboxane A2 Pathway. unassigned -
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30809151&form=6&db=m LSEC Fenestrae Are Preserved Despite Pro-inflammatory Phenotype of Liver Sinusoidal Endothelial Cells in Mice on High Fat Diet. unassigned -
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31930271&form=6&db=m The preventive effect of phenolic-rich extracts from Chinese sumac fruits against nonalcoholic fatty liver disease in rats induced by a high-fat diet. unassigned -
1.14.99.1 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32184095&form=6&db=m COX-2 in liver fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Nose Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11994707&form=6&db=m Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps. causal interaction,unassigned 4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11444591&form=6&db=m Obesity is induced in mice heterozygous for cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12837847&form=6&db=m Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18690356&form=6&db=m Rofecoxib impairs adipose tissue development in a murine model of nutritionally induced obesity. ongoing research,unassigned 4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19106330&form=6&db=m Dietary trans-10, cis-12 conjugated linoleic acid reduces early glomerular enlargement and elevated renal cyclooxygenase-2 levels in young obese fa/fa zucker rats. ongoing research,unassigned 2,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19154413&form=6&db=m Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20021073&form=6&db=m CYP450, COX-2 and Obesity Related Renal Damage. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20107721&form=6&db=m Psoriasis and hypertension: a case-control study. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20122948&form=6&db=m Leptin deficiency-induced obesity exacerbates ultraviolet B radiation-induced cyclooxygenase-2 expression and cell survival signals in ultraviolet B-irradiated mouse skin. ongoing research,unassigned 2,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20448152&form=6&db=m Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes. unassigned -
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20688085&form=6&db=m Cox-2 inhibition attenuates cardiovascular and inflammatory aspects in monosodium glutamate-induced obese rats. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20956003&form=6&db=m Enhanced cyclooxygenase 2-mediated vasorelaxation in coronary arteries from insulin-resistant obese Zucker rats. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21824825&form=6&db=m COX-2 inhibition does not reverse the increased sympathetic modulation in MSG obese rats. therapeutic application,unassigned 1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22523380&form=6&db=m Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23378608&form=6&db=m Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity. therapeutic application,unassigned 4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23620262&form=6&db=m Biological stereoselectivity of atropisomeric natural products and drugs. unassigned -
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23640904&form=6&db=m Cyclooxygenase inhibition improves endothelial vasomotor dysfunction of visceral adipose arterioles in human obesity. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23987235&form=6&db=m Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice. causal interaction,unassigned 4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323963&form=6&db=m [?ptimization of stable angina standard therapy in patients with concomitant osteoarthritis and obesity]. therapeutic application,unassigned 4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24742673&form=6&db=m Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816895&form=6&db=m Effect of a selective cyclooxygenase type 2 inhibitor celecoxib on depression associated with obesity in mice: an approach using behavioral tests. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25123537&form=6&db=m Leptin-mediated inflammatory signaling crucially links visceral fat inflammation to obesity-associated ?-cell dysfunction. causal interaction,unassigned 3,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25125682&form=6&db=m NSAID use reduces breast cancer recurrence in overweight and obese women: role of prostaglandin-aromatase interactions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25185658&form=6&db=m Esophageal COX-2 expression is increased in Barrett's esophagus, obesity, and smoking. causal interaction,unassigned 4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25302170&form=6&db=m Cyclooxygenase-2 and the inflammogenesis of breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25422106&form=6&db=m Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity and insulin resistance. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25584932&form=6&db=m The impact of ethnicity and cardiovascular risk on the pharmacologic management of osteoarthritis: a US perspective. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26020725&form=6&db=m The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26316178&form=6&db=m Hematopoietic cyclooxygenase-2 deficiency increases adipose tissue inflammation and adiposity in obesity. causal interaction,unassigned 4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26482123&form=6&db=m Understanding the molecular aspects of oriental obesity pattern differentiation using DNA microarray. diagnostic usage,unassigned 3,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26516917&form=6&db=m The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26604178&form=6&db=m Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522-1531. ongoing research,unassigned 2,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26604179&form=6&db=m Response to Comment on Francés et al. Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance. Diabetes 2015;64:1522-1531. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26920155&form=6&db=m Cyclooxygenase 2 (rs2745557) Polymorphism and the Susceptibility to Benign Prostate Hyperplasia and Prostate Cancer in Egyptians. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27431935&form=6&db=m Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor ?. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27515272&form=6&db=m Neuronal maturation in the hippocampal dentate gyrus via chronic oral administration of Artemisa annua extract is independent of COX-2 signaling pathway in the diet-induced obesity (DIO) mice model. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27535007&form=6&db=m Augmented oxidative stress and preserved vasoconstriction induced by hydrogen peroxide in coronary arteries in obesity: role of COX-2. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27891824&form=6&db=m Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides. ongoing research,unassigned 2,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27913146&form=6&db=m Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice. ongoing research,unassigned 4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28390422&form=6&db=m High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28783954&form=6&db=m Evidence of changes in alpha-1/AT1 receptor function generated by diet-induced obesity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29132311&form=6&db=m Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. causal interaction,unassigned 2,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29321183&form=6&db=m causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29756563&form=6&db=m Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29764739&form=6&db=m Maternal obesity alters the expression of embryonic regulatory transcripts in the preimplantation ovine conceptus. diagnostic usage,unassigned 2,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30232001&form=6&db=m Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway. ongoing research,unassigned 2,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30661603&form=6&db=m Interleukin-1? and prostaglandin-synthesizing enzymes as modulators of human omental and subcutaneous adipose tissue function. causal interaction,unassigned 3,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31247902&form=6&db=m The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31287731&form=6&db=m Silibinin Differentially Decreases the Aggressive Cancer Phenotype in an In Vitro Model of Obesity and Prostate Cancer. causal interaction,unassigned 1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31704447&form=6&db=m Altered cyclooxygenase-1 and enhanced thromboxane receptor activities underlie attenuated endothelial dilatory capacity of omental arteries in obesity. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32358780&form=6&db=m Ketoprofen alleviates diet-induced obesity and promotes white fat browning in mice via the activation of COX-2 through mTORC1-p38 signaling pathway. unassigned -
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32641048&form=6&db=m Tea polyphenols attenuate liver inflammation by modulating obesity-related genes and down-regulating COX-2 and iNOS expression in high fat-fed dogs. therapeutic application,unassigned 4,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33383181&form=6&db=m Involvement of prostacyclin synthase in high-fat-diet-induced obesity. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Obesity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33929697&form=6&db=m Prostaglandin Endoperoxide H Synthase-2 (PGHS-2) Variants and Risk of Obesity and Microvascular Dysfunction Among Tunisians: Relevance of rs5277 (306G/C) and rs5275 (8473T/C) Genetic Markers. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Obesity, Abdominal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34545251&form=6&db=m Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity. ongoing research,unassigned 2,0
1.14.99.1 Obesity, Maternal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29764739&form=6&db=m Maternal obesity alters the expression of embryonic regulatory transcripts in the preimplantation ovine conceptus. diagnostic usage,unassigned 2,0
1.14.99.1 Obesity, Morbid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31247902&form=6&db=m The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin Resistance. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=105528&form=6&db=m Treatment of premature labor by prostaglandin synthetase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1398208&form=6&db=m [Nifedipine in gynecology and obstetrics] therapeutic application,unassigned 3,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7655136&form=6&db=m Update on tocolytic therapy. therapeutic application,unassigned 4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8506249&form=6&db=m Prostaglandin endoperoxide synthase kinetics in human amnion before and after labor at term and following preterm labor. ongoing research,unassigned 2,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8735752&form=6&db=m Treatment of symptomatic polyhydramnios with indomethacin. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8756578&form=6&db=m The expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase in ovine maternal uterine and fetal tissues during late gestation and labor. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,3,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8785563&form=6&db=m [Adverse effects of ketoprofen after intrauterine exposure. Value of plasma determination] causal interaction,unassigned 3,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8848551&form=6&db=m The induction of cyclooxygenase-2 (COX-2) in intact human amnion tissue by interleukin-4. causal interaction,unassigned 3,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8873235&form=6&db=m 5-Hydroxyeicosatetraenoic acid and human parturition. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9219313&form=6&db=m Mechanism of action of aspirin-like drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9543167&form=6&db=m Prostaglandin endoperoxide H synthase (PGHS) activity and PGHS-1 and -2 messenger ribonucleic acid abundance in human chorion throughout gestation and with preterm labor. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9561441&form=6&db=m Mechanism of action of antiinflammatory drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9831328&form=6&db=m Anti-inflammatory drugs and their mechanism of action. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9877447&form=6&db=m Tumor necrosis factor-alpha upregulates the prostaglandin E2 EP1 receptor subtype and the cyclooxygenase-2 isoform in cultured amnion WISH cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10591596&form=6&db=m Progesterone and prostaglandin H synthase-2 involvement in alcohol-induced preterm birth in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10848506&form=6&db=m Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse. therapeutic application,unassigned 2,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10848516&form=6&db=m Cyclooxygenase-2 inhibitors constrict the fetal lamb ductus arteriosus both in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093043&form=6&db=m Effect of acupuncture treatment on uterine motility and cyclooxygenase-2 expression in pregnant rats. causal interaction,unassigned 1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11174485&form=6&db=m Effect of lipopolysaccharide on uterine contractions and prostaglandin production in pregnant rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336876&form=6&db=m Increase in prostaglandin H synthase 2, but not prostaglandin F2alpha synthase mRNA in intrauterine tissues during betamethasone-induced premature labor and spontaneous term labor in sheep. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12189249&form=6&db=m Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12904319&form=6&db=m Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12973428&form=6&db=m Nonsteroidal antiinflammatory agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14671209&form=6&db=m Differential expression and regulation of microsomal prostaglandin E(2) synthase in human fetal membranes and placenta with infection and in cultured trophoblast cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15181076&form=6&db=m 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase 2 messenger ribonucleic acid expression and immunohistochemical localization in human cervical tissue during term and preterm labor. ongoing research,unassigned 4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15212685&form=6&db=m IFN-gamma-mediated inhibition of COX-2 expression in the placenta from term and preterm labor pregnancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15668523&form=6&db=m Effect of maternal administration of selective cyclooxygenase (COX)-2 inhibitors on renal size, growth factors, proteinases, and COX-2 secretion in the fetal rabbit. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15784717&form=6&db=m The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1{beta}. causal interaction,unassigned 1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15843495&form=6&db=m Modulation of cytokine-induced cyclooxygenase 2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15898432&form=6&db=m [Expression of cyclooxygenase-2 in fetal membranes of premature delivery] causal interaction,unassigned 4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16125046&form=6&db=m Antiprostaglandin drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202923&form=6&db=m The promise of prostaglandins: have they fulfilled their potential as therapeutic targets for the delay of preterm birth? causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16354766&form=6&db=m Novel Targeting of Cyclooxygenase-2 (COX-2) Pre-mRNA Using Antisense Morpholino Oligonucleotides Directed to the 3' Acceptor and 5' Donor Splice Sites of Exon 4: Suppression of COX-2 Activity in Human Amnion-Derived WISH and Myometrial Cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16364008&form=6&db=m Evidence for interleukin-10-mediated inhibition of cyclo- oxygenase-2 expression and prostaglandin production in preterm human placenta. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16399999&form=6&db=m Effects of progesterone on iNOS, COX-2, and collagen expression in the cervix. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17327104&form=6&db=m [Expression of cyclooxygenase-2 and 15-prostaglandin dehydrogenase of placenta and fetal membranes in patients of preterm labor] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18089593&form=6&db=m Dose-dependent effects of meloxicam administration on cyclooxygenase-1 and cyclooxygenase-2 protein expression in intrauterine tissues and fetal tissues of a sheep model of preterm labor. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18639206&form=6&db=m Effect of calcium ionophore A23187 on prostaglandin synthase type 2 and 15-hydroxy-prostaglandin dehydrogenase expression in human chorion trophoblast cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519349&form=6&db=m Evidence for a spatial and temporal regulation of prostaglandin-endoperoxide synthase 2 expression in human amnion in term and preterm parturition. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21821146&form=6&db=m Inhibition of epoxy-eicosanoid degradation improves the tocolytic effects of indomethacin in the uterus from pregnant women. therapeutic application,unassigned 4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22001990&form=6&db=m Effect of indometacin pretreatment on protamine sulfate-mediated relaxation of the isolated rat uterus: the role of the antioxidative defense system. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22973051&form=6&db=m The microRNA (miR)-199a/214 Cluster Mediates Opposing Effects of Progesterone and Estrogen on Uterine Contractility during Pregnancy and Labor. causal interaction,unassigned 2,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23121458&form=6&db=m Are Periodontal Bacterial Profiles and Placental Inflammatory Infiltrate in Pregnancy Related to Birth Outcomes? causal interaction,unassigned 4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24770033&form=6&db=m Safety of Ibuprofen tocolysis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28810692&form=6&db=m Resveratrol protects from lipopolysaccharide-induced inflammation in the uterus and prevents experimental preterm birth. unassigned -
1.14.99.1 Obstetric Labor, Premature http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33786046&form=6&db=m Activities of Andrographis paniculata (AS201-01) Tablet on Cox-2 and Prostaglandin Expression of Placental of Plasmodium berghei Infected Mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Ocular Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16023100&form=6&db=m 2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits. therapeutic application,unassigned 2,0
1.14.99.1 Ocular Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26990912&form=6&db=m Comparison of topically applied flurbiprofen or bromfenac ophthalmic solution on post-operative ocular hypertension in canine patients following cataract surgery. therapeutic application,unassigned 4,0
1.14.99.1 Odontogenic Cyst, Calcifying http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29930772&form=6&db=m Calcifying odontogenic cyst: A 26-year retrospective clinicopathological analysis and immunohistochemical study. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Odontogenic Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17251521&form=6&db=m Signaling pathways regulating IL-1alpha-induced COX-2 expression. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Odontogenic Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123497&form=6&db=m Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Odontogenic Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29508125&form=6&db=m Investigation of clinicopathological parameters and expression of COX-2, bcl-2, PCNA, and p53 in primary and recurrent sporadic odontogenic keratocysts. diagnostic usage,unassigned 3,0
1.14.99.1 Odontogenic Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34398475&form=6&db=m Cyclooxygenase-2 protein expression modulates cell proliferation and apoptosis in solid ameloblastoma and odontogenic keratocyst. An immunohistochemical study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Odontogenic Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19457709&form=6&db=m An overview on the expression of cyclooxygenase-2 in tumors of the head and neck. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Odontogenic Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21215666&form=6&db=m A comparative immunohistochemical analysis of COX-2, p53, and Ki-67 expression in keratocystic odontogenic tumors. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Odontogenic Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21496105&form=6&db=m Potential relevance of cyclooxygenase-2 expression in keratocystic odontogenic tumours - an immunohistochemical study. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Odontogenic Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649281&form=6&db=m Cyclooxygenase-2 expression in keratocystic odontogenic tumour decreased following decompression. unassigned -
1.14.99.1 Odontogenic Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24831259&form=6&db=m Expression of Human Papillomavirus is Correlated with Ki-67 and COX-2 Expressions in Keratocystic Odontogenic Tumor. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Odontogenic Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26005470&form=6&db=m Immunohistochemical analysis of COX-2 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma: A comparative study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Odontogenic Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27279422&form=6&db=m TGF-? in jaw tumor fluids induces RANKL expression in stromal fibroblasts. therapeutic application,unassigned 1,0
1.14.99.1 Odontogenic Tumors http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30820416&form=6&db=m Protein 53, B-Cell Lymphoma-2, Cyclooxygenase-2, and CD105 Reactivity in Keratocystic Odontogenic Tumors: An Immunohistochemical Analysis. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11121536&form=6&db=m Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,1
1.14.99.1 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11563634&form=6&db=m Expression of prostaglandin H synthase-2 in human brain tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14508834&form=6&db=m Cyclooxygenase-2 in oligodendroglial neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15484698&form=6&db=m Cyclooxygenase-2 in oligodendroglioma: possible prognostic significance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16621014&form=6&db=m Microwave-assisted antigen retrieval and incubation with cox-2 antibody of archival paraffin-embedded human oligodendroglioma and astrocytomas. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20052522&form=6&db=m Cyclooxygenase-2 expression in astrocytes and microglia in human oligodendroglioma and astrocytoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20382140&form=6&db=m mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,1,0
1.14.99.1 Oligodendroglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21360625&form=6&db=m Combination of a ptgs2 inhibitor and an epidermal growth factor receptor-signaling inhibitor prevents tumorigenesis of oligodendrocyte lineage-derived glioma-initiating cells. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Oligohydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2340255&form=6&db=m Oligohydramnios associated with prostaglandin synthetase inhibitors in preterm labour. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Oligohydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6772782&form=6&db=m Oligohydramnios and transient neonatal anuria: a possible association with the maternal use of prostaglandin synthetase inhibitors. causal interaction,unassigned 4,0
1.14.99.1 Oligohydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8238144&form=6&db=m The effect of low-dose aspirin on fetal urine output and amniotic fluid volume. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Oligohydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11094215&form=6&db=m Severe oligohydramnios induced by cyclooxygenase-2 inhibitor nimesulide. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Oligohydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067231&form=6&db=m Oligohydramnios and fetal renal sonographic appearances related to prostaglandin synthetase inhibitors. A case report. causal interaction,unassigned 3,0
1.14.99.1 Oligohydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202923&form=6&db=m The promise of prostaglandins: have they fulfilled their potential as therapeutic targets for the delay of preterm birth? causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Oligospermia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20188355&form=6&db=m Cyclooxygenase-2 in testes of infertile men: evidence for the induction of prostaglandin synthesis by interleukin-1beta. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Oliguria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20639308&form=6&db=m Does the use of non-steroidal anti-inflammatory drugs after cardiac surgery increase the risk of renal failure? causal interaction,unassigned 3,0
1.14.99.1 Opioid-Induced Constipation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33908261&form=6&db=m An opioid receptor-independent mechanism underlies motility dysfunction and visceral hyperalgesia in opioid-induced bowel dysfunction. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Opisthorchiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160279&form=6&db=m Increased expression of TLR-2, COX-2, and SOD-2 genes in the peripheral blood leukocytes of opisthorchiasis patients induced by Opisthorchis viverrini antigen. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Opportunistic Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8453676&form=6&db=m Accelerated hematopoietic recovery and protective effect of the cyclooxygenase inhibitor indomethacin in bacterial infection of neutropenic mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Optic Nerve Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9441697&form=6&db=m Cyclooxygenase-1 and cyclooxygenase-2 in the human optic nerve head. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15914620&form=6&db=m Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Optic Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17604021&form=6&db=m Signal transduction pathways for epidermal growth factor stimulated cyclooxygenase-2 induction in astrocytes. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Oral Submucous Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874015&form=6&db=m Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes. causal interaction,unassigned 4,0
1.14.99.1 Oral Submucous Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12581384&form=6&db=m The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Oral Submucous Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26369479&form=6&db=m Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1
1.14.99.1 Oral Submucous Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31516243&form=6&db=m Expression of cyclooxygenase 2 in oral submucous fibrosis: An immunohistochemical pilot study. ongoing research,unassigned 4,0
1.14.99.1 Oral Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32811507&form=6&db=m Discovery of the possible mechanisms in kouyanqing granule for treatment of oral ulcers based on network pharmacology. therapeutic application,unassigned 1,0
1.14.99.1 Orbital Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17062883&form=6&db=m Expression of cyclooxygenase-2 in orbital fibroadipose connective tissues of Graves' ophthalmopathy patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1729286&form=6&db=m In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1765987&form=6&db=m The therapeutic approaches of community based primary care practitioners to osteoarthritis of the hip in an elderly patient. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2027111&form=6&db=m NSAID induction of interleukin 1/catabolin inhibitor production by osteoarthritic synovial tissue. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8628978&form=6&db=m Clinical implications of selective cyclooxygenase-2 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630630&form=6&db=m A review of the clinical pharmacokinetics of meloxicam. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630635&form=6&db=m Meloxicam in osteoarthritis: a 6-month, double-blind comparison with diclofenac sodium. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9051872&form=6&db=m A randomized, double-blind, crossover comparative endoscopy study on the gastroduodenal tolerability of a highly specific cyclooxygenase-2 inhibitor, flosulide, and naproxen. therapeutic application,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9219313&form=6&db=m Mechanism of action of aspirin-like drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9249647&form=6&db=m Pain management in osteoarthritis: the role of COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9433877&form=6&db=m Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9509287&form=6&db=m When are NSAIDs appropriate in osteoarthritis? therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9751091&form=6&db=m Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9783758&form=6&db=m Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of COX-inhibiting Therapies (SELECT) trial in osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9858439&form=6&db=m Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,4
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10093892&form=6&db=m [Specific COX-2 inhibitors: prospects of therapy with new analgesic and anti-inflammatory substances] diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10193997&form=6&db=m Role of cyclooxygenase-1 and -2 in health and disease. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390126&form=6&db=m Role and regulation of cyclooxygenase-2 during inflammation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411562&form=6&db=m Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419769&form=6&db=m Interactions between the inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) pathways: implications for therapeutic intervention in osteoarthritis. therapeutic application,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10419773&form=6&db=m The role of COX-2 produced by cartilage in arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10463513&form=6&db=m Selective cyclooxygenase-2 inhibitors for the treatment of arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10493683&form=6&db=m Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10500058&form=6&db=m A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis.Rofecoxib Osteoarthritis Endoscopy Study Group. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10509845&form=6&db=m Celecoxib, a selective cyclooxygenase-2 inhibitor for the treatment of rheumatoid arthritis and osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10555907&form=6&db=m Effect of specific COX-2 inhibition in osteoarthritis of the knee: a 6 week double blind, placebo controlled pilot study of rofecoxib. Rofecoxib Osteoarthritis Pilot Study Group. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10560596&form=6&db=m Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhibitor: a randomized controlled trial. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10638109&form=6&db=m Comparative efficacy and tolerability of nimesulide and piroxicam in osteoarthritis with specific reference to chondroprotection: a double blind randomised study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10643176&form=6&db=m Celecoxib for the treatment of pain and inflammation: the preclinical and clinical results. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10649604&form=6&db=m Cyclooxygenase activity in chondrocytes from osteoarthritic and healthy cartilage. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10693877&form=6&db=m Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial. The Rofecoxib Osteoarthritis Endoscopy Multinational Study Group. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10710483&form=6&db=m COX-2 and colon cancer: Potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10719816&form=6&db=m Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10762021&form=6&db=m COX-2 and colon cancer: potential targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10804043&form=6&db=m Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10817549&form=6&db=m Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip. Rofecoxib Phase III Protocol 035 Study Group. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10871971&form=6&db=m A randomized trial of the efficacy and tolerability of the COX-2 inhibitor rofecoxib vs ibuprofen in patients with osteoarthritis. Rofecoxib/Ibuprofen Comparator Study Group. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10877012&form=6&db=m Pharmacokinetics, COX-2 specificity, and tolerability of supratherapeutic doses of rofecoxib in humans. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10900877&form=6&db=m [New treatment of pain and fever in rheumatoid arthritis and arthrosis. The first cyclooxygenase-2 inhibitors show promising results] therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10943882&form=6&db=m Thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors. A report of four cases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10975859&form=6&db=m The induction of cell death in human osteoarthritis chondrocytes by nitric oxide is related to the production of prostaglandin E2 via the induction of cyclooxygenase-2. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11005360&form=6&db=m Cyclooxygenase-2 inhibitor celecoxib: a possible cause of gastropathy and hypoprothrombinemia. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11032097&form=6&db=m Defining COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11041909&form=6&db=m Gastrointestinal tolerability of the selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib compared with nonselective COX-1 and COX-2 inhibitors in osteoarthritis. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090038&form=6&db=m COX-2 inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11115219&form=6&db=m Rofecoxib, a new cyclooxygenase 2 inhibitor, shows sustained efficacy, comparable with other nonsteroidal anti-inflammatory drugs: a 6-week and a 1-year trial in patients with osteoarthritis. Osteoarthritis Studies Group. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11143737&form=6&db=m The optimal analgesic dose of rofecoxib: Overview of six randomized controlled trials. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158633&form=6&db=m Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11311743&form=6&db=m Cyclooxygenase inhibitors--current status and future prospects. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11317164&form=6&db=m The hepatic safety and tolerability of the novel cyclooxygenase-2 inhibitor celecoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11318071&form=6&db=m Osteoarthritis management: the role of cyclooxygenase-2-selective inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11334356&form=6&db=m Liquid chromatographic-mass spectrometric determination of celecoxib in plasma using single-ion monitoring and its use in clinical pharmacokinetics. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11405384&form=6&db=m A multicenter, randomized, controlled trial to evaluate the safety profile, tolerability, and efficacy of rofecoxib in advanced elderly patients with osteoarthritis. ongoing research,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11519771&form=6&db=m Economic evaluation of rofecoxib versus nonselective nonsteroidal anti-inflammatory drugs for the treatment of osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11523183&form=6&db=m When to consider a COX-2 inhibitor for osteoarthritis of the knee. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11665972&form=6&db=m In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695069&form=6&db=m Double-blind study comparing the long-term efficacy of the COX-2 inhibitor nimesulide and naproxen in patients with osteoarthritis. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695246&form=6&db=m What have we learned from the large outcomes trials of COX-2 selective inhibitors? The rheumatologist's perspective. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11697296&form=6&db=m [COX-2 inhibitor in arthrosis. Discontinuation before operations not necessary] therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11708426&form=6&db=m Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11717181&form=6&db=m Mechanistic studies on the reversible metabolism of rofecoxib to 5-hydroxyrofecoxib in the rat: evidence for transient ring opening of a substituted 2-furanone derivative using stable isotope-labeling techniques. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11718158&form=6&db=m Celecoxib in osteoarthritis and rheumatoid arthritis: new preparation. As disappointing as rofecoxib. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11754710&form=6&db=m Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819916&form=6&db=m [Pharmacology of non-steroidal anti-inflammatory drugs and ENT pathology] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11833521&form=6&db=m Meeting the therapeutic challenge of the patient with osteoarthritis. therapeutic application,unassigned 2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11840453&form=6&db=m Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11866383&form=6&db=m A rapid and sensitive high-performance liquid chromatography assay for rofecoxib in human serum. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11892706&form=6&db=m Upper gastrointestinal tolerability of celecoxib compared with diclofenac in the treatment of osteoarthritis and rheumatoid arthritis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11906292&form=6&db=m 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1). therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11918520&form=6&db=m Pathophysiology and first-line treatment of osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11945151&form=6&db=m Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11950252&form=6&db=m Efficacy and safety of the COX-2 specific inhibitor valdecoxib in the management of osteoarthritis of the hip: a randomized, double-blind, placebo-controlled comparison with naproxen. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961974&form=6&db=m [A critical evaluation of side effect data on COX-2 inhibitors] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12017209&form=6&db=m Efficacy and tolerability profile of etoricoxib in patients with osteoarthritis: A randomized, double-blind, placebo and active-comparator controlled 12-week efficacy trial. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12017215&form=6&db=m A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12022317&form=6&db=m Increase in lifetime adverse drug reactions, service utilization, and disease severity among patients who will start COX-2 specific inhibitors: quantitative assessment of channeling bias and confounding by indication in 6689 patients with rheumatoid arthritis and osteoarthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124863&form=6&db=m Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants. therapeutic application,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124864&form=6&db=m Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12136904&form=6&db=m Licofelone (ML-3000), a dual inhibitor of 5-lipoxygenase and cyclooxygenase, reduces the level of cartilage chondrocyte death in vivo in experimental dog osteoarthritis: inhibition of pro-apoptotic factors. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12167567&form=6&db=m Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204485&form=6&db=m Pharmacoeconomics of coxib therapy. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12204486&form=6&db=m The impact of pain management on quality of life. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12216162&form=6&db=m [Osteoarthritis and COX-2 inhibitors] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12216163&form=6&db=m [Treatment of osteoarthritis with COX-2 inhibitors: good for the stomach, but bad for the patient?] therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12219613&form=6&db=m [Mobility and quality of life for arthrosis and rheumatism patients. Modern pain management with selective cox-2 inhibition] therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12374621&form=6&db=m Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. ongoing research,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12518073&form=6&db=m [Comparison of the pharmacologic effect of diacerein and a selective COX-2 inhibitor in the mouse induced-granuloma model] causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12571763&form=6&db=m Rofecoxib improves quality of life in patients with hip or knee osteoarthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12583353&form=6&db=m Cardiovascular thrombotic events and COX-2 inhibitors: results in patients with osteoarthritis receiving rofecoxib. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12604692&form=6&db=m Opposite effects of rofecoxib on nuclear factor-kappaB and activating protein-1 activation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12605743&form=6&db=m [Cost-effectiveness analysis of the use of celecoxib for the treatment of osteoarthritis] therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12629931&form=6&db=m Cyclooxygenase-2: from arthritis treatment to new indications for the prevention and treatment of cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12637116&form=6&db=m The prevalence of cardiorenal risk factors in patients prescribed nonsteroidal anti-inflammatory drugs: data from managed care. diagnostic usage,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664583&form=6&db=m Cyclooxygenase-2 in human pathological disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12688204&form=6&db=m [Selective Cox-2 inhibitor in osteoarthritis and rheumatoid arthritis. No increased risk for the heart] causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12703120&form=6&db=m [Selective cyclooxygenase-2 inhibitors and the digestive tract] causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12708604&form=6&db=m Comparison of the efficacy and tolerability of dexibuprofen and celecoxib in the treatment of osteoarthritis of the hip. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12716445&form=6&db=m COX-2: Where are we in 2003? - Be strong and resolute: continue to use COX-2 selective inhibitors at recommended dosages in appropriate patients. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12730549&form=6&db=m Pharmacoutilization and costs of osteoarthritis: changes induced by the introduction of a cyclooxygenase-2 inhibitor into clinical practice. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12740337&form=6&db=m Incidence of gastroduodenal ulcers in patients with rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or placebo: a multicentre, randomised, double blind study. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12745131&form=6&db=m Blood pressure control and rates of edema following the administration of the cyclooxygenase-2 specific inhibitors celecoxib versus rofecoxib in patients with systemic hypertension and osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12752891&form=6&db=m Evaluation of cyclooxygenase 2 inhibitor use in patients admitted to a large teaching hospital. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12800058&form=6&db=m Lumiracoxib (Novartis). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12804506&form=6&db=m Single dose oral celecoxib for postoperative pain. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12868200&form=6&db=m [Coxibs: highly selective cyclooxygenase-2 inhibitors. Part I. Clinical efficacy] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902855&form=6&db=m COX-2 inhibitors and cancer therapeutics: potential roles for inhibitors of COX-2 in combination with cytotoxic therapy: reports from a symposium held in conjunction with the Radiation Therapy Oncology Group June 2001 Meeting. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12904159&form=6&db=m Cardiovascular hazard of selective COX-2 inhibitors: myth or reality? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12907325&form=6&db=m The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12917777&form=6&db=m Licofelone (Merckle). causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960491&form=6&db=m Role of eicosanoids in structural degradation in osteoarthritis. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552698&form=6&db=m The prospective use of COX-2 inhibitors for the treatment of temporomandibular joint inflammatory disorders. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14552704&form=6&db=m Clinical pharmacology of selective COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14585912&form=6&db=m Channelling of patients taking NSAIDs or cyclooxygenase-2-specific inhibitors and its effect on interpretation of outcomes. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14592543&form=6&db=m The mechanism of action of aspirin. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14613272&form=6&db=m Comparing the efficacy of cyclooxygenase 2-specific inhibitors in treating osteoarthritis: appropriate trial design considerations and results of a randomized, placebo-controlled trial. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14626471&form=6&db=m Prescribing COX-2s for patients new to cyclo-oxygenase inhibition therapy. therapeutic application,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14677191&form=6&db=m Celecoxib has a positive effect on the overall metabolism of hyaluronan and proteoglycans in human osteoarthritic cartilage. ongoing research,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14687407&form=6&db=m Osteoarthritis and rheumatoid arthritis: will new data clarify the risk:benefit ratio of cyclooxygenase-2 inhibitors? unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14705234&form=6&db=m Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14712755&form=6&db=m Verification of a decision analytic model assumption using real-world practice data: implications for the cost effectiveness of cyclo-oxygenase 2 inhibitors (COX-2s). diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14713399&form=6&db=m Outcome measures in osteoarthritis: randomized controlled trials. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14729583&form=6&db=m Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14752170&form=6&db=m Osteoarthritis therapy--are there still unmet needs? causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14752171&form=6&db=m Safety of anti-inflammatory treatment--new ways of thinking. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14752172&form=6&db=m Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14989043&form=6&db=m Cyclooxygenase-2 inhibitor treatment of older osteoarthritis patients. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15068837&form=6&db=m Celecoxib: a potent cyclooxygenase-2 inhibitor in cancer prevention. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15100180&form=6&db=m Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15100590&form=6&db=m A randomized, double-blind, parallel-group study comparing the analgesic effect of etoricoxib to placebo, naproxen sodium, and acetaminophen with codeine using the dental impaction pain model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102339&form=6&db=m S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15133778&form=6&db=m Drug switching patterns among patients with rheumatoid arthritis and osteoarthritis using COX-2 specific inhibitors and non-specific NSAIDs. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15153172&form=6&db=m Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254755&form=6&db=m Cross talk between COX-2 inhibitor and hyaluronic acid in osteoarthritic chondrocytes. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15262246&form=6&db=m Participation of cyclooxygenase-1 in prostaglandin E2 release from synovitis tissue in primary osteoarthritis in vitro. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15313405&form=6&db=m Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15334426&form=6&db=m Efficacy and safety of four doses of lumiracoxib versus diclofenac in patients with knee or hip primary osteoarthritis: a phase II, four-week, multicenter, randomized, double-blind, placebo-controlled trial. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15337183&form=6&db=m Immunohistochemical localization of cyclooxygenase-1 and -2 in synovial tissues from patients with internal derangement or osteoarthritis of the temporomandibular joint. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15338504&form=6&db=m Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15451967&form=6&db=m The impact of drug coverage on COX-2 inhibitor use in Medicare. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15457451&form=6&db=m Up-regulation of microsomal prostaglandin E synthase 1 in osteoarthritic human cartilage: critical roles of the ERK-1/2 and p38 signaling pathways. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15476906&form=6&db=m Effects of valdecoxib in the treatment of chronic low back pain: results of a randomized, placebo-controlled trial. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15485012&form=6&db=m Efficacy and tolerability of lumiracoxib versus placebo in patients with osteoarthritis of the hand. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15485309&form=6&db=m Celecoxib: a novel treatment for lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15487881&form=6&db=m Risk assessment of NSAID-induced gastrointestinal toxicity in ambulatory care patients. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498796&form=6&db=m The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15545508&form=6&db=m Treating osteoarthritis with cyclooxygenase-2-specific inhibitors: what are the benefits of avoiding blood pressure destabilization? therapeutic application,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15579005&form=6&db=m Novel insights and therapeutical applications in the field of inhibitors of COX-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15607056&form=6&db=m [Analysis of cost-minimization treatment with paracetamol or COX-2 inhibitors (rofecoxib) for pain from arthrosis of the knee or hip] diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630735&form=6&db=m Cyclooxygenase-2 specific inhibitors and upper gastrointestinal tolerability in patients with osteoarthritis receiving concomitant low dose aspirin: pooled analysis of 2 trials. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15638077&form=6&db=m Isolation and structural characterization of the photolysis products of etoricoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645573&form=6&db=m COX-2 drug may help treat osteoarthritis. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15651713&form=6&db=m Efficacy of lumiracoxib in osteoarthritis: a review of nine studies. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655868&form=6&db=m I have coronary artery disease and osteoarthritis. What can you tell me about COX-2 inhibitors and their possible effects on my heart? ongoing research,unassigned 2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15668361&form=6&db=m The Effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension, osteoarthritis, and type 2 diabetes mellitus. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15669946&form=6&db=m Prescriptions for cyclooxygenase-2 inhibitors and other nonsteroidal anti-inflammatory agents in a medicaid managed care population: African Americans versus Caucasians. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15719708&form=6&db=m Rationale for testing the cardiovascular risk for patients with COX-2 inhibitors on the basis of biomarker NT-proBNP. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15742426&form=6&db=m Trial of tramadol/acetaminophen tablets for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15827035&form=6&db=m A regional audit of the use of COX-2 selective non-steroidal anti-inflammatory drugs (NSAIDs) in rheumatology clinics in the West Midlands, in relation to NICE guidelines. diagnostic usage,therapeutic application,unassigned 1,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15843089&form=6&db=m Ischemic colitis associated with rofecoxib. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15853470&form=6&db=m Valdecoxib for the management of chronic and acute pain. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15881487&form=6&db=m Lumiracoxib in the treatment of osteoarthritis, rheumatoid arthritis and acute postoperative dental pain: results of three dose-response studies. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974939&form=6&db=m COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974941&form=6&db=m Global safety of coxibs and NSAIDs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16008217&form=6&db=m In vivo effects of tepoxalin, an inhibitor of cyclooxygenase and lipoxygenase, on prostanoid and leukotriene production in dogs with chronic osteoarthritis. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16082648&form=6&db=m Need for common internal controls when assessing the relative efficacy of pharmacologic agents using a meta-analytic approach: case study of cyclooxygenase 2-selective inhibitors for the treatment of osteoarthritis. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16093206&form=6&db=m Enhanced in vitro percutaneous absorption and in vivo anti-inflammatory effect of a selective cyclooxygenase inhibitor using microemulsion. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16178945&form=6&db=m Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16259055&form=6&db=m Molecular targets of dietary polyphenols with anti-inflammatory properties. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16271911&form=6&db=m Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16276709&form=6&db=m The efficacy and toleration of celecoxib (Celebrex) in the treatment of osteoarthritis in Nigeria: a multicentre study. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16287921&form=6&db=m Inhibition of COX-2 by celecoxib in the canine groove model of osteoarthritis. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16321158&form=6&db=m Etoricoxib in the treatment of osteoarthritis over 52-weeks: a double-blind, active-comparator controlled trial [NCT00242489]. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16372823&form=6&db=m Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376111&form=6&db=m NF-kappaBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-alpha-induced chondrocytes. ongoing research,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16476713&form=6&db=m Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between celecoxib and aceclofenac. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510063&form=6&db=m When should COX-2 selective NSAIDs be used for osteoarthritis and rheumatoid arthritis? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16529763&form=6&db=m Improved solubilization of Celecoxib in U-type nonionic microemulsions and their structural transitions with progressive aqueous dilution. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16652435&form=6&db=m Licofelone reduces progression of structural changes in a canine model of osteoarthritis under curative conditions: effect on protease expression and activity. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16875903&form=6&db=m Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program: cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16922642&form=6&db=m Clinical pharmacology of etoricoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16926961&form=6&db=m What influences seniors' choice of medications for osteoarthritis? Qualitative inquiry. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16952493&form=6&db=m Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16998298&form=6&db=m [A Case of Complete Regression of Hepatocellular Carcinoma during Administration of COX-2 Inhibitor.] causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17039120&form=6&db=m COX-2 specific inhibitors in the management of osteoarthritis of the knee: a placebo-controlled, randomized, double-blind study. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17198754&form=6&db=m Intra-articular injection of the cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in anterior cruciate ligament-transected knee in rats: role of excitatory amino acids. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17359944&form=6&db=m Celecoxib inhibits Na+ currents in rat dorsal root ganglion neurons. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17380211&form=6&db=m Lumiracoxib. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17401567&form=6&db=m Prostaglandin E2 receptors EP1 and EP4 are up-regulated in rabbit chondrocytes by IL-1beta, but not by TNFalpha. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17459794&form=6&db=m COXIBs and non-selective NSAIDs in the gastroenterological setting: what should patients and physicians do? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17516707&form=6&db=m Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17611980&form=6&db=m The effect of low-dose aspirin on the decreased risk of development of dyspepsia and gastrointestinal ulcers associated to cyclooxygenase-2 selective inhibitors. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638097&form=6&db=m The role of COX-2 inhibitors in rheumatoid and osteoarthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17638098&form=6&db=m Etodolac: An overview of a selective COX-2 inhibitor. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17639563&form=6&db=m COX-1 and -2 activity of rose hip. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17763056&form=6&db=m Influence of polymers on the bioavailability of microencapsulated celecoxib. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17940520&form=6&db=m Are COX-2 selective inhibitors safer than NSAIDs for patients with osteoarthritis and rheumatoid arthritis? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17986996&form=6&db=m The possibilities of pharmacological treatment of cartilage damage in degenerative joint disease. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17999057&form=6&db=m Clinical use and pharmacological properties of selective COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18085997&form=6&db=m Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18096078&form=6&db=m Cyclooxygenase inhibition lowers prostaglandin E2 release from articular cartilage and reduces apoptosis but not proteoglycan degradation following an impact load in vitro. causal interaction,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18177922&form=6&db=m COX-2 selective inhibitors in the treatment of osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18180584&form=6&db=m [The role of nonsteroidal anti-inflammatory drugs, oral preparations, and viscosupplementation in conservative treatment of cartilage lesions]. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18268076&form=6&db=m In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18297851&form=6&db=m [Side effects of COX-2 selective inhibitors. Critic related with its administration in patients with rheumatoid arthritis and osteoarthritis] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18328090&form=6&db=m Long-term retention on treatment with lumiracoxib 100 mg once or twice daily compared with celecoxib 200 mg once daily: a randomised controlled trial in patients with osteoarthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18383442&form=6&db=m Risk of ischaemic cardiovascular events from selective cyclooxygenase-2 inhibitors in osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18389471&form=6&db=m Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18405470&form=6&db=m Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18430793&form=6&db=m Effect of an academic detailing intervention on the utilization rate of cyclooxygenase-2 inhibitors in the elderly. therapeutic application,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18472996&form=6&db=m The role of tramadol in current treatment strategies for musculoskeletal pain. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18547825&form=6&db=m Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18576346&form=6&db=m Application of inflammation-responsive promoter for an in vitro arthritis model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18637715&form=6&db=m Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18778469&form=6&db=m A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18926729&form=6&db=m The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19010065&form=6&db=m Microsomal prostaglandin E2 synthase 1 expression in basic calcium phosphate crystal-stimulated fibroblasts: role of prostaglandin E2 and the EP4 receptor. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19014495&form=6&db=m Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19063590&form=6&db=m Bioactivation of lumiracoxib by peroxidases and human liver microsomes: identification of multiple quinone imine intermediates and GSH adducts. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19132456&form=6&db=m Perceived barriers to paracetamol (acetaminophen) prescribing, especially following rofecoxib withdrawal from the market. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19167595&form=6&db=m Comparison of the effectiveness and tolerability of lidocaine patch 5% versus celecoxib for osteoarthritis-related knee pain: post hoc analysis of a 12 week, prospective, randomized, active-controlled, open-label, parallel-group trial in adults. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203472&form=6&db=m Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19274754&form=6&db=m Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19327236&form=6&db=m Effects of celecoxib on the expression of osteoprotegerin, energy metabolism and cell viability in cultured human osteoblastic cells. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19589894&form=6&db=m Early response to COX-2 inhibitors as a predictor of overall response in osteoarthritis: pooled results from two identical trials comparing etoricoxib, celecoxib and placebo. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19614837&form=6&db=m Safety and tolerability of 3-week and 6-month dosing of Deramaxx (deracoxib) chewable tablets in dogs. therapeutic application,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19624842&form=6&db=m An exploration of the ability of tepoxalin to ameliorate the degradation of articular cartilage in a canine in vitro model. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19669924&form=6&db=m Pharmacophore generation and atom-based 3D-QSAR of novel 2-(4-methylsulfonylphenyl)pyrimidines as COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19733721&form=6&db=m Effects of the cyclooxygenase inhibiting nitric oxide donator naproxcinod versus naproxen on systemic blood pressure in patients with osteoarthritis. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19807303&form=6&db=m Value of cyclooxygenase-2 specific inhibitors in the management of osteoarthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20067770&form=6&db=m Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110006&form=6&db=m Changes in physicians' practice of prescribing cyclooxygenase-2 inhibitor after market withdrawal of rofecoxib: a retrospective study of physician-patient pairs in Taiwan. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20224826&form=6&db=m [Selective inhibitors of cyclooxygenase-2 (COX-2), celecoxib and parecoxib: a systematic review.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20225218&form=6&db=m Novel insights into the mechanism of decreased expression of type X collagen in human mesenchymal stem cells from patients with osteoarthritis cultured on nitrogen-rich plasma polymers: Implication of cyclooxygenase-1. ongoing research,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20378913&form=6&db=m The (-765 G->C) promoter variant of the COX-2/PTGS2 gene is associated with a lower risk for end-stage hip and knee osteoarthritis. ongoing research,unassigned 2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20457212&form=6&db=m Nimesulide aggravates redox imbalance and calcium dependent mitochondrial permeability transition leading to dysfunction in vitro. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20476993&form=6&db=m COX-2 inhibition and pain management: a review summary. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20639878&form=6&db=m A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20862685&form=6&db=m H3K4 methylation by Set1A contributes to IL-1-induced COX-2 and iNOS expression in human OA chondrocytes. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20870807&form=6&db=m Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20972845&form=6&db=m Efficacy and safety of flavocoxid compared with naproxen in subjects with osteoarthritis of the knee- a subset analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21042022&form=6&db=m Efficacy and Safety of the Selective Cyclooxygenase-2 Inhibitor Celecoxib in the Treatment of Rheumatoid Arthritis and Osteoarthritis in Japan. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21062104&form=6&db=m Value of information in the osteoarthritis setting: cost effectiveness of COX-2 selective inhibitors, traditional NSAIDs and proton pump inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21142617&form=6&db=m Persistence with non-selective NSAIDs and celecoxib among patients with gastroesophageal reflux disease and osteoarthritis or rheumatoid arthritis. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219337&form=6&db=m Population pharmacokinetics of mavacoxib in osteoarthritic dogs. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21371681&form=6&db=m Effects of Naproxcinod on Blood Pressure in Patients with Osteoarthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21417982&form=6&db=m The association between cyclooxygenase-2 (COX-2/PTGS2) gene polymorphism and osteoarthritis. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21443958&form=6&db=m Therapeutic Trajectory Following Intra-Articular Hyaluronic acid Injection in Knee Osteoarthritis - Meta-Analysis. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21485709&form=6&db=m Bioequivalence study of two brands of meloxicam tablets in healthy human Pakistani male subjects. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21900785&form=6&db=m Meta-analysis: cyclooxygenase-2 inhibitors are no better than nonselective nonsteroidal anti-inflammatory drugs with proton pump inhibitors in regard to gastrointestinal adverse events in osteoarthritis and rheumatoid arthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21905007&form=6&db=m Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21905013&form=6&db=m Changing the outcome of osteoarthritis: still a challenge for cyclooxygenase 2 inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22114888&form=6&db=m Managing the adverse effects of nonsteroidal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22160883&form=6&db=m In vitro characterization of chitosan gels for buccal delivery of celecoxib: influence of a penetration enhancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22294637&form=6&db=m MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes. causal interaction,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340319&form=6&db=m Adiponectin receptor 1 mediates the difference in adiponectin- induced prostaglandin E2 production in rheumatoid arthritis and osteoarthritis synovial fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22351432&form=6&db=m 5-Lipoxygenase Metabolic Contributions to NSAID-Induced Organ Toxicity. causal interaction,unassigned 2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22373734&form=6&db=m Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure-activity relationship for anti-inflammatory drug. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22433003&form=6&db=m Licofelone inhibits interleukin-18-induced pro-inflammatory cytokine release and cellular proliferation in human mesangial cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22648246&form=6&db=m Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22708229&form=6&db=m Cox-2 inhibitors and the risk of cardiovascular thrombotic events. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22898213&form=6&db=m Current considerations for the management of musculoskeletal pain in Asian countries: a special focus on cyclooxygenase-2 inhibitors and non-steroid anti-inflammation drugs. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23357220&form=6&db=m Cox-2 gene variants in migraine. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23396231&form=6&db=m Celastrol, an inhibitor of heat shock protein 90? potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23452054&form=6&db=m Greater number of narcotic analgesic prescriptions for osteoarthritis is associated with falls and fractures in elderly adults. diagnostic usage,therapeutic application,unassigned 2,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23611898&form=6&db=m MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1?-induced catabolic effects in human articular chondrocytes. causal interaction,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23964078&form=6&db=m Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24084190&form=6&db=m Intra-articular injection of the selective cyclooxygenase-2 inhibitor meloxicam (Mobic) reduces experimental osteoarthritis and nociception in rats. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24169227&form=6&db=m [SECOT consensus on medial femorotibial osteoarthritis]. diagnostic usage,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24323963&form=6&db=m [?ptimization of stable angina standard therapy in patients with concomitant osteoarthritis and obesity]. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24692832&form=6&db=m Comparative assessment of the effectiveness and tolerability of lornoxicam 8 mg BID and diclofenac 50 mg TID in adult indian patients with osteoarthritis of the hip or knee: A 4-week, double-blind, randomized, comparative, multicenter study. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24825461&form=6&db=m Genetic influences on hand osteoarthritis in finnish women--a replication study of candidate genes. diagnostic usage,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25133963&form=6&db=m Etoricoxib in the treatment of Korean patients with osteoarthritis in a double-blind, randomized controlled trial. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25382123&form=6&db=m Optimization of a nonviral transfection system to evaluate Cox-2 controlled interleukin-4 expression for osteoarthritis gene therapy in vitro. ongoing research,unassigned 2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25433956&form=6&db=m How to mechanistically explain the CONDOR study data. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25584932&form=6&db=m The impact of ethnicity and cardiovascular risk on the pharmacologic management of osteoarthritis: a US perspective. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25879879&form=6&db=m Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26000299&form=6&db=m Study of osteoarthritis treatment with anti-inflammatory drugs: cyclooxygenase-2 inhibitor and steroids. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26061682&form=6&db=m The cost-effectiveness of celecoxib versus non-steroidal anti-inflammatory drugs plus proton-pump inhibitors in the treatment of osteoarthritis in Saudi Arabia. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26244515&form=6&db=m DNA Sequence Variants in the Five Prime Untranslated Region of the Cyclooxygenase-2 Gene Are Commonly Found in Healthy Dogs and Gray Wolves. causal interaction,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26360837&form=6&db=m Influence of genetic polymorphisms on the pharmacokinetics of celecoxib and its two main metabolites in healthy Chinese subjects. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26499345&form=6&db=m Echinocystic Acid Inhibits IL-1?-Induced COX-2 and iNOS Expression in Human Osteoarthritis Chondrocytes. ongoing research,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26505439&form=6&db=m Differential expression of COX-2 in osteoarthritis and rheumatoid arthritis. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26648294&form=6&db=m [Changes of six serum biomarkers of rabbits with experimental osteoarthritis]. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26882928&form=6&db=m Does flare trial design affect the effect size of non-steroidal anti-inflammatory drugs in symptomatic osteoarthritis? A systematic review and meta-analysis. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26981698&form=6&db=m Celecoxib for the treatment of pain and inflammation: the preclinical and clinical results. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27034605&form=6&db=m Lactoferrin from Camelus dromedarius Inhibits Nuclear Transcription Factor-kappa B Activation, Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Stimulated Human Chondrocytes. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27196460&form=6&db=m Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27515563&form=6&db=m Epigallocatechin-3-O-gallate up-regulates microRNA-199a-3p expression by down-regulating the expression of cyclooxygenase-2 in stimulated human osteoarthritis chondrocytes. ongoing research,unassigned 2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27703516&form=6&db=m Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27790020&form=6&db=m Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27864660&form=6&db=m Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metabolite. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28078252&form=6&db=m The Evaluation of the Effect of Herbal Extract on Osteoarthritis: In Vitro and In Vivo Study. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28101475&form=6&db=m Anticonvulsive Effects of Licofelone on Status Epilepticus Induced by Lithium-pilocarpine in Wistar Rats: a Role for Inducible Nitric Oxide Synthase. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28413731&form=6&db=m Meloxicam ameliorates the cartilage and subchondral bone deterioration in monoiodoacetate-induced rat osteoarthritis. therapeutic application,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29112682&form=6&db=m Cross-Coupling Effects of Silencing of Cyclooxygenase-2 (COX-2)/Aggrecanase-1 and Over-Expressed Insulin-Like Growth Factor 1 (IGF-1) in an Osteoarthritis Animal Model. ongoing research,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29385156&form=6&db=m Combination COX-2 inhibitor and metformin attenuate rate of joint replacement in osteoarthritis with diabetes: A nationwide, retrospective, matched-cohort study in Taiwan. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29453810&form=6&db=m A case-control study and meta-analysis reveal the association between COX-2 G-765C polymorphism and primary end-stage hip and knee osteoarthritis. causal interaction,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29601910&form=6&db=m Safety assessment of vitacoxib: 180-day chronic oral toxicity studies. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29663159&form=6&db=m Evaluation of the effect of polyphenol of escin compared with ibuprofen and dexamethasone in synoviocyte model for osteoarthritis: an in vitro study. ongoing research,unassigned 2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786356&form=6&db=m [EFFICACY OF SEQUENTIAL TREATMENT WITH ADDUCTOR CANAL NERVE BLOCK AND CYCLOOXYGENASE 2 SELECTIVE INHIBITOR AFTER TOTAL KNEE ARTHROPLASTY]. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29890262&form=6&db=m Disease-modifying effects of COX-2 selective inhibitors and non-selective NSAIDs in osteoarthritis: a systematic review. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29930022&form=6&db=m Cyclooxygenase-2, Asymmetric Dimethylarginine and the Cardiovascular Hazard from NSAIDs. ongoing research,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30347274&form=6&db=m Preparation, characterization, and evaluation of celecoxib eutectic mixtures with adipic acid/saccharin for improvement of wettability and dissolution rate. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30498758&form=6&db=m A Randomized, Double Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Safety and Efficacy of Curene® versus Placebo in Reducing Symptoms of Knee OA. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30510777&form=6&db=m The roles of prostaglandin F2 in regulating the expression of matrix metalloproteinase-12 via an insulin growth factor-2-dependent mechanism in sheared chondrocytes. causal interaction,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30568809&form=6&db=m Blood Glutathione Peroxidase Activity in Patients with Osteoarthritis Treated with Oxicams. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30585984&form=6&db=m Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30719603&form=6&db=m Stichopus chloronotus aqueous extract as a chondroprotective agent for human chondrocytes isolated from osteoarthitis articular cartilage in vitro. causal interaction,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30774225&form=6&db=m Meloxicam in the management of post-operative pain: Narrative review. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30938133&form=6&db=m The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis. ongoing research,unassigned 2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31073922&form=6&db=m Safety of Cyclooxygenase-2 Inhibitors in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31137797&form=6&db=m Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation. therapeutic application,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31148341&form=6&db=m Cirsium japonicum var. maackii and apigenin block Hif-2?-induced osteoarthritic cartilage destruction. ongoing research,unassigned 2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31186043&form=6&db=m Pedobarography: a novel approach to test the efficacy of treatments for lameness; an experience with mavacoxib in dogs with elbow osteoarthritis. therapeutic application,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31313358&form=6&db=m Population-based case-control study: chemoprotection of colorectal cancer with non-aspirin nonsteroidal anti-inflammatory drugs and other drugs for pain control. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31339385&form=6&db=m Celecoxib for the treatment of musculoskeletal arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31495059&form=6&db=m The COX-2 inhibitor etoricoxib reduces experimental osteoarthritis and nociception in rats: The roles of TGF-?1 and NGF expressions in chondrocytes. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31564512&form=6&db=m Effects of Celecoxib on the QTc Interval: A Thorough QT/QTc Study. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666999&form=6&db=m Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31765607&form=6&db=m Osthole ameliorates cartilage degradation by downregulation of NF-?B and HIF-2? pathways in an osteoarthritis murine model. unassigned -
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31784400&form=6&db=m Human bone mesenchymal stem cells-derived exosomes overexpressing microRNA-26a-5p alleviate osteoarthritis via down-regulation of PTGS2. ongoing research,unassigned 1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31937359&form=6&db=m Combatting joint pain and inflammation by dual inhibition of monoacylglycerol lipase and cyclooxygenase-2 in a rat model of osteoarthritis. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32212546&form=6&db=m PHARMACOKINETICS OF ORAL MAVACOXIB IN CARIBBEAN FLAMINGOS (PHOENICOPTERUS RUBER RUBER). therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32307719&form=6&db=m Synthesis of stable isotope-labelled firocoxib. therapeutic application,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32330796&form=6&db=m Etoricoxib decreases subchondral bone mass and attenuates biomechanical properties at the early stage of osteoarthritis in a mouse model. therapeutic application,unassigned 3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32669521&form=6&db=m Comparative efficacy and safety of Verbascox® - a proprietary herbal extract capable of inhibiting human cyclooxygenase-2 - and celecoxib for knee osteoarthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32693125&form=6&db=m Colchicine mesoporous silica nanoparticles/hydrogel composite loaded cotton patches as a new encapsulator system for transdermal osteoarthritis management. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32723437&form=6&db=m Cyclooxygenase-2 inhibitor rofecoxib prevents chondrocytes against hypertrophy via Wnt/?-catenin pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32794641&form=6&db=m Antiosteoarthritic effect of Punica granatum L. peel extract on collagenase induced osteoarthritis rat by modulation of COL-2, MMP-3, and COX-2 expression. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32971951&form=6&db=m Chondroprotective Actions of Selective COX-2 Inhibitors In Vivo: A Systematic Review. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982340&form=6&db=m Analysis of the Health and Budgetary Impact of Chondroitin Sulfate Prescription in the Treatment of Knee Osteoarthritis Compared to NSAIDs and COXIBs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33062167&form=6&db=m Molecular Imaging of Inflammation in Osteoarthritis Using a Water-Soluble Fluorocoxib. ongoing research,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33485983&form=6&db=m A hybrid platform featuring nanomagnetic ligand fishing for discovering COX-2 selective inhibitors from aerial part of Saussurea laniceps Hand.-Mazz. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33672354&form=6&db=m Modulation of Inflammatory Mediators by Polymeric Nanoparticles Loaded with Anti-Inflammatory Drugs. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34082759&form=6&db=m Long-term safety evaluation of Daxocox® tablets (enflicoxib) in dogs after weekly oral administrations for seven months. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34127028&form=6&db=m Expression of VEGF-A Signaling Pathway in Cartilage of ACLT-induced Osteoarthritis Mouse Model. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34304363&form=6&db=m Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34466385&form=6&db=m Cyclooxygenase-2 regulates PTHrP transcription in human articular chondrocytes and is involved in the pathophysiology of osteoarthritis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Osteoarthritis, Hip http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090038&form=6&db=m COX-2 inhibitors. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis, Hip http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11950252&form=6&db=m Efficacy and safety of the COX-2 specific inhibitor valdecoxib in the management of osteoarthritis of the hip: a randomized, double-blind, placebo-controlled comparison with naproxen. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis, Hip http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12571763&form=6&db=m Rofecoxib improves quality of life in patients with hip or knee osteoarthritis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis, Hip http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15771318&form=6&db=m [From PICO to search terms on the Internet: how to find relevant information? New coxibs: do they have a better gastrointestinal safety?] diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis, Hip http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16128596&form=6&db=m Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. ongoing research,unassigned 1,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10555907&form=6&db=m Effect of specific COX-2 inhibition in osteoarthritis of the knee: a 6 week double blind, placebo controlled pilot study of rofecoxib. Rofecoxib Osteoarthritis Pilot Study Group. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10560596&form=6&db=m Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhibitor: a randomized controlled trial. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10638109&form=6&db=m Comparative efficacy and tolerability of nimesulide and piroxicam in osteoarthritis with specific reference to chondroprotection: a double blind randomised study. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10817549&form=6&db=m Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip. Rofecoxib Phase III Protocol 035 Study Group. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11523183&form=6&db=m When to consider a COX-2 inhibitor for osteoarthritis of the knee. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12641865&form=6&db=m The cost-effectiveness of acetaminophen, NSAIDs, and selective COX-2 inhibitors in the treatment of symptomatic knee osteoarthritis. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15102339&form=6&db=m S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15478167&form=6&db=m A comparison of the efficacy and safety of nonsteroidal antiinflammatory agents versus acetaminophen in the treatment of osteoarthritis: a meta-analysis. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17039120&form=6&db=m COX-2 specific inhibitors in the management of osteoarthritis of the knee: a placebo-controlled, randomized, double-blind study. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18471798&form=6&db=m Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18547825&form=6&db=m Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18653484&form=6&db=m Protective effects of licofelone, a 5-lipoxygenase and cyclooxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first Multi-Centre Clinical Trial using quantitative MRI. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20128070&form=6&db=m Gastrointestinal and cardiovascular risk of non-selective NSAIDs and COX-2 inhibitors in elderly patients with knee osteoarthritis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23964444&form=6&db=m The efficacy of Curcuma Longa L. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. therapeutic application,unassigned 4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786374&form=6&db=m [EXPERIMENTAL STUDY ON LENTIVIRUS-MEDIATED MULTI-GENES CO-TRANSFECTION IN BONE MARROW MESENCHYMAL STEM CELLS FOR TREATMENT OF KNEE OSTEOARTHRITIS IN CYNOMOLGUS MONKEY]. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30568809&form=6&db=m Blood Glutathione Peroxidase Activity in Patients with Osteoarthritis Treated with Oxicams. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30585984&form=6&db=m Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32037857&form=6&db=m Effect of Systematic Exercise Rehabilitation on Patients With Knee Osteoarthritis: A Randomized Controlled Trial. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32669521&form=6&db=m Comparative efficacy and safety of Verbascox® - a proprietary herbal extract capable of inhibiting human cyclooxygenase-2 - and celecoxib for knee osteoarthritis. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Osteoarthritis, Knee http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34345283&form=6&db=m Increased expression of cyclooxygenase-2 in synovium tissues and synovial fluid from patients with knee osteoarthritis is associated with downregulated microRNA-758-3p expression. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Osteoarthropathy, Primary Hypertrophic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31508314&form=6&db=m Safety and efficacy of cyclooxygenase-2 inhibition for treatment of primary hypertrophic osteoarthropathy: A single-arm intervention trial. therapeutic application,unassigned 4,0
1.14.99.1 Osteoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11048802&form=6&db=m Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Osteochondrodysplasias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30972680&form=6&db=m Protective effect of Astragaloside IV to inhibit thiram-induced tibial dyschondroplasia. causal interaction,unassigned 1,0
1.14.99.1 Osteochondroma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30761249&form=6&db=m Cyclooxygenase-2 expression correlates with development, progression, metastasis, and prognosis of osteosarcoma: a meta-analysis and trial sequential analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=870901&form=6&db=m Calcium metabolism in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1005735&form=6&db=m Failure of indomethacin to reduce hypercalcemia in patients with breast cancer. causal interaction,unassigned 3,0
1.14.99.1 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11315993&form=6&db=m Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009007&form=6&db=m Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14585714&form=6&db=m The effect of COX-2 inhibitors on periprosthetic osteolysis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15683659&form=6&db=m Investigations using clinically relevant particles. Reference: Im et al., The effect of COX-2 inhibitors on periprosthetic osteolysis, Biomaterials 25, 269-275 (2004). unassigned -
1.14.99.1 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21601661&form=6&db=m Protective effects of COX-2 inhibitor on titanium-particle-induced inflammatory osteolysis via the down-regulation of RANK/RANKL. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Osteolysis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23651067&form=6&db=m Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Osteoma, Osteoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11048802&form=6&db=m Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Osteoma, Osteoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11764357&form=6&db=m Cyclooxygenase-2 inhibitor for pain management in osteoid osteoma. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteoma, Osteoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11844065&form=6&db=m Mechanism of intramedullary high intensity area on T2-weighted magnetic resonance imaging in osteoid osteoma: a possible role of COX-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Osteoma, Osteoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11853083&form=6&db=m COX-1 and COX-2 expression in osteoid osteomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Osteoma, Osteoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15566132&form=6&db=m Effect of rofecoxib on pain caused by osteoid osteoma. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22266364&form=6&db=m Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Osteomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28682162&form=6&db=m Cyclooxygenase-2 (COX-2) polymorphism rs689466 may contribute to the increased susceptibility to post-traumatic osteomyelitis in Chinese population. unassigned -
1.14.99.1 Osteomyelitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34220937&form=6&db=m Genetic Determinants for Bacterial Osteomyelitis: A Focused Systematic Review of Published Literature. therapeutic application,unassigned 1,0
1.14.99.1 Osteophyte http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664583&form=6&db=m Cyclooxygenase-2 in human pathological disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Osteophyte http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25620693&form=6&db=m Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645019&form=6&db=m New drugs and new targets. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16791706&form=6&db=m The effect of cyclooxygenase-2 inhibitors on bone mineral density: results from the Canadian Multicentre Osteoporosis Study. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18231633&form=6&db=m Feedback Control of the Arachidonate Cascade in Osteoblastic Cells by 15-deoxy-Delta-Prostaglandin J(2). therapeutic application,unassigned 1,0
1.14.99.1 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25075626&form=6&db=m Chitooligosaccharides prevent osteopenia by promoting bone formation and suppressing bone resorption in ovariectomised rats: possible involvement of COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33800915&form=6&db=m MYLK and PTGS1 Genetic Variations Associated with Osteoporosis and Benign Breast Tumors in Korean Women. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Osteoporosis, Postmenopausal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22932114&form=6&db=m [Effect of cyclooxygenase-2 on bone loss in ovariectomized rats]. unassigned -
1.14.99.1 Osteoporosis, Postmenopausal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31411919&form=6&db=m Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency. unassigned -
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9085144&form=6&db=m Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9258749&form=6&db=m Differential effects of nonsteroidal anti-inflammatory drugs on constitutive and inducible prostaglandin G/H synthase in cultured bone cells. unassigned -
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9661070&form=6&db=m Regulation of prostaglandin G/H synthase-2 expression by interleukin-1 in human osteoblast-like cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9987964&form=6&db=m [Hormones and auto-paracrine tumor growth regulators in osteogenic sarcoma] causal interaction,unassigned 4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10411562&form=6&db=m Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11179483&form=6&db=m Dose-dependent modulation of apoptosis and cyclooxygenase-2 expression in human 1547 osteosarcoma cells by NS-398, a selective cyclooxygenase-2 inhibitor. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11882979&form=6&db=m [Osteosarcoma: biochemical and endocrinological studies as a basis for its pathogenetic treatments] causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12012007&form=6&db=m The anti-apoptotic property of NS-398 at high dose can be mediated in part through NF-kappaB activation, hsp70 induction and a decrease in caspase-3 activity in human osteosarcoma cells. ongoing research,unassigned 2,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12024286&form=6&db=m Cyclooxygenase-2 expression in pediatric sarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576442&form=6&db=m Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679640&form=6&db=m Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067366&form=6&db=m The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15289892&form=6&db=m A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15638270&form=6&db=m Cyclooxygenase-2 expression in canine appendicular osteosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15700850&form=6&db=m Cyclooxygenase-2 expression in uterine leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16182328&form=6&db=m Antineoplastic effect of the cyclooxygenase inhibitor meloxicam on canine osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16219634&form=6&db=m Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16289620&form=6&db=m Lipopolysaccharide stimulates the production of prostaglandin E2 and the receptor Ep4 in osteoblasts. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16420297&form=6&db=m In vitro effects of meloxicam with or without doxorubicin on canine osteosarcoma cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16818639&form=6&db=m Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16956425&form=6&db=m Effects of dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG-63 human osteosarcoma cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17536311&form=6&db=m Expression of cyclooxygenase-2 in osteosarcoma of bone. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17887937&form=6&db=m A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. ongoing research,unassigned 4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17934334&form=6&db=m Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18078766&form=6&db=m Celecoxib, a cyclooxygenase-2 inhibitor, induces apoptosis in human osteosarcoma cell line MG-63 via down-regulation of PI3K/Akt. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18333755&form=6&db=m Integrin-mediated expression of bone formation-related genes in osteoblast-like cells in response to fluid shear stress: roles of extracellular matrix, Shc, and mitogen-activated protein kinase. ongoing research,unassigned 4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18797196&form=6&db=m COX-2 expression correlates with survival in patients with osteosarcoma lung metastases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19326179&form=6&db=m Cyclooxygenase-2 Overexpression Predicts Poor Survival in Patients with High-grade Extremity Osteosarcoma: A Pilot Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19330880&form=6&db=m Differentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: implication for chronic articular disease. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20876365&form=6&db=m Cyclooxygenase-2 Expression in Animal Cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20926002&form=6&db=m Celecoxib Inhibits ?-Catenin-dependent Survival of the Human Osteosarcoma MG-63 Cell Line. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21145881&form=6&db=m Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves ?v?5 integrin, ILK and AP-1-dependent pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21236332&form=6&db=m 15-Deoxy-?12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21240382&form=6&db=m Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,2
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21874258&form=6&db=m Cyclooxygenase-2 expression is not associated with clinical outcome in synovial sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22546756&form=6&db=m Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22633646&form=6&db=m Immunohistochemical Expression of COX-2, mPGES and EP2 Receptor in Normal and Reactive Canine Bone and in Canine Osteosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22783382&form=6&db=m Predicting chemosensitivity in osteosarcoma prior to chemotherapy: An investigational study of biomarkers with immunohistochemistry. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22922217&form=6&db=m Exposure of Wistar rats to 24-h psycho-social stress alters gene expression in the inferior colliculus. causal interaction,unassigned 2,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22922684&form=6&db=m The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22925934&form=6&db=m Expression of the aryl hydrocarbon receptor pathway and cyclooxygenase-2 in dog tumors. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23336375&form=6&db=m [Expression of hypoxia-inducible factor 1? in osteosarcoma and its value in predicting chemosensitivity]. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23857285&form=6&db=m Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24059095&form=6&db=m Limited inhibitory effects of non-steroidal antiinflammatory drugs on in vitro osteogenic differentiation in canine cells. therapeutic application,unassigned 2,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24358237&form=6&db=m Quantitative assessment of the association of COX-2 (Cyclooxygenase-2) immunoexpression with prognosis in human osteosarcoma: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24416158&form=6&db=m Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24666548&form=6&db=m The impact of COX-2 on invasion of osteosarcoma cell and its mechanism of regulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816920&form=6&db=m Letter regarding the article of Jiao G. J. et al. entitled "Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis". therapeutic application,unassigned 1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25705166&form=6&db=m Analysis of gene expression in cyclooxygenase-2-overexpressed human osteosarcoma cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25803042&form=6&db=m T-cell activation and early gene response in dogs. causal interaction,unassigned 1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26050198&form=6&db=m ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,3
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26136990&form=6&db=m Expression and clinical significance of cyclooxygenase-2 and microRNA-143 in osteosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26180515&form=6&db=m Cyclooxygeanse-2 promotes metastasis in osteosarcoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26476537&form=6&db=m P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26592832&form=6&db=m Celecoxib inhibits cell growth and modulates the expression of matrix metalloproteinases in human osteosarcoma MG-63 cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28053596&form=6&db=m Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28454270&form=6&db=m FosB transcription factor regulates COX-2 expression in colorectal cancer cells without affecting PGE2 expression. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30334373&form=6&db=m Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30761249&form=6&db=m Cyclooxygenase-2 expression correlates with development, progression, metastasis, and prognosis of osteosarcoma: a meta-analysis and trial sequential analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31263675&form=6&db=m Catechins-Modified Selenium-Doped Hydroxyapatite Nanomaterials for Improved Osteosarcoma Therapy Through Generation of Reactive Oxygen Species. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934887&form=6&db=m Elucidating the mechanisms of action of parecoxib in the MG-63 osteosarcoma cell line. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32474521&form=6&db=m Correlation between the changes of serum COX 2, APE1, VEGF, TGF-? and TSGF levels and prognosis in patients with osteosarcoma before and after treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32667910&form=6&db=m The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33570264&form=6&db=m Enhanced expression of cyclooxygenase-2 related multi-drug resistance gene in melanoma and osteosarcoma cell lines by TSG-6 secreted from canine adipose-derived mesenchymal stem/stromal cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751829&form=6&db=m The role of COX expression in the prognostication of overall survival of canine and feline cancer: A systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34136395&form=6&db=m Aberrant Expression of PAFAH1B3 Affects Proliferation and Apoptosis in Osteosarcoma. causal interaction,unassigned 1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34269487&form=6&db=m Osteosarcoma Stem Cell Potent Gallium(III)-Polypyridyl Complexes Bearing Diflunisal. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34316376&form=6&db=m lncRNA-PACER upregulates COX-2 and PGE2 through the NF-?B pathway to promote the proliferation and invasion of colorectal-cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Otitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32517205&form=6&db=m A Glycosaminoglycan-Rich Fraction from Sea Cucumber Isostichopus badionotus Has Potent Anti-Inflammatory Properties In Vitro and In Vivo. ongoing research,unassigned 2,0
1.14.99.1 Otitis Media http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16500468&form=6&db=m Cyclooxygenase 2 expression in otitis media with effusion. ongoing research,unassigned 3,0
1.14.99.1 Otitis Media http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084463&form=6&db=m Expressions of cyclooxygenase 1 and 2 in endotoxin-induced otitis media with effusion in the rat. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Otitis Media with Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8352483&form=6&db=m Experimental otitis media with effusion induced by platelet activating factor. unassigned -
1.14.99.1 Otitis Media with Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16500468&form=6&db=m Cyclooxygenase 2 expression in otitis media with effusion. ongoing research,unassigned 3,0
1.14.99.1 Otitis Media with Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17084463&form=6&db=m Expressions of cyclooxygenase 1 and 2 in endotoxin-induced otitis media with effusion in the rat. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Otorhinolaryngologic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819916&form=6&db=m [Pharmacology of non-steroidal anti-inflammatory drugs and ENT pathology] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Otorhinolaryngologic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12378813&form=6&db=m [Nimesulide (Aulin)--the selective COX-2 inhibitor in the treatment of ENT diseases] therapeutic application,unassigned 4,0
1.14.99.1 Otosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3501679&form=6&db=m Bone resorption in experimental otosclerosis in rats. causal interaction,unassigned 4,0
1.14.99.1 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8233489&form=6&db=m Ototoxicity of salicylate, nonsteroidal antiinflammatory drugs, and quinine. causal interaction,unassigned 2,0
1.14.99.1 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8892578&form=6&db=m Effect of leukotriene inhibitor on otoacoustic emissions in salicylate ototoxicity. causal interaction,unassigned 3,0
1.14.99.1 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20080359&form=6&db=m Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Ototoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25779473&form=6&db=m Assessment of the potential ototoxicity of high-dose celecoxib, a selective cyclooxygenase-2 inhibitor, in rats. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Ovarian Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2569331&form=6&db=m Formation of ovarian follicular cysts and corpora lutea after treatment with antihistamine or indomethacin in prepubertal gilts. causal interaction,unassigned 1,0
1.14.99.1 Ovarian Cysts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14747187&form=6&db=m Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,1
1.14.99.1 Ovarian Hyperstimulation Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18166186&form=6&db=m Inhibition of cyclooxygenase-2 (COX-2) by meloxicam decreases the incidence of ovarian hyperstimulation syndrome in a rat model. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Ovarian Hyperstimulation Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819316&form=6&db=m Ovarian hyperstimulation syndrome inhibition by targeting VEGF, COX-2 and calcium pathways: a preclinical randomized study. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Ovarian Hyperstimulation Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31040646&form=6&db=m Can a cyclooxygenase inhibitor be an option for treatment of ovarian hyperstimulation syndrome? ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1611619&form=6&db=m Studies of a tumor-associated antigen, COX-1, recognized by a monoclonal antibody. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7589737&form=6&db=m Clinical evaluations of a new ovarian cancer marker, COX-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8391924&form=6&db=m Sensitivity of tumoricidal function in macrophages from different anatomical sites of cancer patients to modulation of arachidonic acid metabolism. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11408945&form=6&db=m Cyclooxygenase-2 expression in normal ovaries and epithelial ovarian neoplasms. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489832&form=6&db=m Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605016&form=6&db=m Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11801560&form=6&db=m Effects of nonsteroidal anti-inflammatory agents (NSAIDs) on ovarian carcinoma cell lines: preclinical evaluation of NSAIDs as chemopreventive agents. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11972392&form=6&db=m Cyclooxygenase-2 (COX-2), epidermal growth factor receptor (EGFR), and Her-2/neu expression in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12181243&form=6&db=m Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12469191&form=6&db=m Expression of cyclooxygenase-2 and its relationship to p53 accumulation in ovarian adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12615701&form=6&db=m Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12750273&form=6&db=m Identification of the human IAI.3B promoter element and its use in the construction of a replication-selective adenovirus for ovarian cancer therapy. diagnostic usage,unassigned 2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12921553&form=6&db=m [Inhibitory effect of NS398 on the proliferation of human ovarian cancer cell lines CAOV3 and OVCAR3 in vitro] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14633672&form=6&db=m Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766256&form=6&db=m Cyclooxygenase-1 and 2 in normal and malignant human ovarian epithelium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14984945&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14984962&form=6&db=m Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14999227&form=6&db=m A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15205395&form=6&db=m Cyclooxygenase-2 and its role in ovulation: a 2004 account. causal interaction,unassigned 2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15781636&form=6&db=m Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15838264&form=6&db=m Endothelin-1 Stimulates Cyclooxygenase-2 Expression in Ovarian Cancer Cells Through Multiple Signaling Pathways: Evidence for Involvement of Transactivation of the Epidermal Growth Factor Receptor. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963707&form=6&db=m Prostaglandin E2 production in ovarian cancer cell lines is regulated by cyclooxygenase-1, not cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15970376&form=6&db=m Significance of cyclooxygenase 2 and MDR1/P-glycoprotein coexpression in ovarian cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15993933&form=6&db=m Feasibility of performing chemoprevention trials in women at elevated risk of ovarian carcinoma: initial examination of celecoxib as a chemopreventive agent. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16028376&form=6&db=m [COX-2 expression and ovarian cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16044148&form=6&db=m Loss of TNF-alpha-regulated COX-2 expression in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16328030&form=6&db=m Clinical implications of expression of cyclooxygenase-2 related to angiogenesis in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376882&form=6&db=m Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16456945&form=6&db=m Cyclooxygenase-2 expression is higher in ovarian cancer tissue adjacent to endometriosis than in ovarian cancer without comorbid endometriosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16463667&form=6&db=m Expression of cyclooxygenase-2 in ovarian cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16521433&form=6&db=m [Classical and novel molecular prognostic factors in ovarian cancers] causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16612714&form=6&db=m COX-2 and preoperative CA-125 level are strongly correlated with survival and clinical responsiveness to chemotherapy in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16797680&form=6&db=m Cyclooxygenase 1 and 2 mRNA and protein expression in the Gallus domesticus model of ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16831230&form=6&db=m Cyclo-oxygenase-2 (Cox-2) expression and resistance to platinum versus platinum/paclitaxel containing chemotherapy in advanced ovarian cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16996114&form=6&db=m Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17341442&form=6&db=m Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17582802&form=6&db=m Inhibitory effect of meloxicam, a selective cyclooxygenase-2 inhibitor, and ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, on the growth of human ovarian cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17667594&form=6&db=m The effects of combining docetaxel and cyclooxygenase-2 inhibitors on proliferation and apoptosis in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17936723&form=6&db=m Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian cancer and colon cancer is independent of COX-2 expression levels. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18158574&form=6&db=m Anti-tumor effect of non-steroidal anti-inflammatory drugs on human ovarian cancers. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18171606&form=6&db=m The prognostic significance of COX-2 and survivin expression in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173552&form=6&db=m Strong evidence for up-regulation of cyclooxygenase-1 in head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18306389&form=6&db=m Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18314621&form=6&db=m [NF-kappaB subunit p65/RelA expression in ovarian carcinoma: prognostic impact and link to COX-2 overexpression] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18362203&form=6&db=m Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,3,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18488158&form=6&db=m Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18498063&form=6&db=m Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus). causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606441&form=6&db=m VEGF expression and the effect of NSAIDs on ascites cell proliferation in the hen model of ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18798061&form=6&db=m Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18988002&form=6&db=m Effects of a cyclooxygenase-1-selective inhibitor in a mouse model of ovarian cancer, administered alone or in combination with ibuprofen, a nonselective cyclooxygenase inhibitor. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18997734&form=6&db=m Classification using hierarchical clustering of tumor-infiltrating immune cells identifies poor prognostic ovarian cancers with high levels of COX expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19116446&form=6&db=m Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19235530&form=6&db=m Effects of a selective cyclooxygenase-1 inhibitor in SKOV-3 ovarian carcinoma xenograft-bearing mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19471247&form=6&db=m Treatment with cyclooxygenase-2 inhibitors enables repeated administration of vaccinia virus for control of ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861248&form=6&db=m [Small interfering RNA-mediated COX-2 gene silencing inhibits the proliferation and migration of human ovarian cancer cell line CAOV-3.] causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20304053&form=6&db=m Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH(2))D(3)) and prostaglandin E(2) (PGE(2)) serum level in ovarian cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20392831&form=6&db=m Gonadotropins Induce Tumor Cell Migration and Invasion by Increasing Cyclooxygenases Expression and Prostaglandin E2 Production in Human Ovarian Cancer Cells. causal interaction,unassigned 4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20404564&form=6&db=m The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20559705&form=6&db=m Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20622109&form=6&db=m Ovarian cancer G protein-coupled receptor 1-dependent and -independent vascular actions to acidic pH in human aortic smooth muscle cells. ongoing research,unassigned 4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21187340&form=6&db=m Inducible COX-2-dependent apoptosis in human ovarian cancer cells. therapeutic application,unassigned 1,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21627839&form=6&db=m Phase II study of the combination carboplatin plus celecoxib in heavily pre-treated recurrent ovarian cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21955569&form=6&db=m The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689176&form=6&db=m A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,3,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22807982&form=6&db=m Effect of the combination of a cyclooxygenase-1 selective inhibitor and taxol on proliferation, apoptosis and angiogenesis of ovarian cancer in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23193911&form=6&db=m Antitumor properties of taxol in combination with cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian tumor growth in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23205124&form=6&db=m Effects of cyclooxygenase inhibitors on survival time in ovarian cancer xenograft-bearing mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23317244&form=6&db=m Roles of E-cadherin and cyclooxygenase enzymes in predicting different survival patterns of optimally cytoreduced serous ovarian cancer patients. causal interaction,diagnostic usage,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23422504&form=6&db=m Prognostic role of cyclooxygenase-2 in epithelial ovarian cancer: A meta-analysis of observational studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23426648&form=6&db=m Effects of combining Taxol and cyclooxygenase inhibitors on the angiogenesis and apoptosis in human ovarian cancer xenografts. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23495037&form=6&db=m Ceramide induces COX-2-dependent induction of apoptosis in human ovarian cancer OVCAR-3 cells by mechanisms that partially overlap with actions of resveratrol. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23524891&form=6&db=m Promotion of osteoclast differentiation and activation in spite of impeded osteoblast-lineage differentiation under acidosis: Effects of acidosis on bone metabolism. unassigned -
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23875078&form=6&db=m Selective cyclooxygenase inhibitors increase paclitaxel sensitivity in taxane-resistant ovarian cancer by suppressing P-glycoprotein expression. causal interaction,ongoing research,therapeutic application,unassigned 2,1,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23962610&form=6&db=m Ovarian cancers arising from endometriosis: A microenvironmental biomarker study including ER, HNF1ß, p53, PTEN, BAF250a, and COX-2. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23978451&form=6&db=m Flaxseed enriched diet-mediated reduction in ovarian cancer severity is correlated to the reduction of prostaglandin E2 in laying hen ovaries. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24155779&form=6&db=m Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24324582&form=6&db=m High MUC2 expression in ovarian cancer is inversely associated with the M1/M2 ratio of tumor-associated macrophages and patient survival time. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24517373&form=6&db=m Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24520227&form=6&db=m Synergistic Effect of COX-2 Inhibitor on Paclitaxel-Induced Apoptosis in the Human Ovarian Cancer Cell Line OVCAR-3. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24531199&form=6&db=m Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24832612&form=6&db=m PET radiotracer [¹?F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24969217&form=6&db=m COX2 and PGE2 mediate EGF-induced E-cadherin-independent human ovarian cancer cell invasion. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25007180&form=6&db=m Immunohistochemical visualization of pro-inflammatory cytokines and enzymes in ovarian tumors. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25011213&form=6&db=m COX-2 expression pattern is related to ovarian cancer differentiation and prognosis, but is not consistent with new model of pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25335121&form=6&db=m Effects of cyclooxygenase-2 gene silencing on the biological behavior of SKOV3 ovarian cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25342321&form=6&db=m Effects of SC-560 in combination with cisplatin or taxol on angiogenesis in human ovarian cancer xenografts. ongoing research,unassigned 4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25408841&form=6&db=m Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25667511&form=6&db=m Vitamin d inhibits ovarian cancer cell line proliferation in combination with celecoxib and suppresses cyclooxygenase-2 expression. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25734181&form=6&db=m Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25972361&form=6&db=m Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26257064&form=6&db=m Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26817996&form=6&db=m Synergistic COX2 Induction by IFN? and TNF? Self-Limits Type-1 Immunity in the Human Tumor Microenvironment. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27074576&form=6&db=m The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27111555&form=6&db=m COX-1 Inhibitors: Beyond Structure Toward Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27172738&form=6&db=m Vascular endothelial growth factor (VEGF) and cyclooxygenase 2 (COX 2) immunostaining in ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27490802&form=6&db=m CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28599493&form=6&db=m Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28677781&form=6&db=m Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway. unassigned -
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152148&form=6&db=m COX-2 expression in ovarian cancer: an updated meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29324448&form=6&db=m The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29932878&form=6&db=m COX-2 inhibition by celecoxib in epithelial ovarian cancer attenuates E-cadherin suppression through reduced Snail nuclear translocation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30049816&form=6&db=m RGS10 Regulates the Expression of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha through a G Protein-Independent Mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30242499&form=6&db=m Preventative effect of celecoxib in dimethylbenz[a]anthracene-induced ovarian cancer in rats. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31172046&form=6&db=m Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31229884&form=6&db=m Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31387969&form=6&db=m Urinary PGE-M levels and risk of ovarian cancer. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31822119&form=6&db=m Cyclooxygenase 2 Promotes Proliferation and Invasion in Ovarian Cancer Cells via the PGE2/NF-?B Pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32253841&form=6&db=m Cyclooxygenase-2 promotes ovarian cancer cell migration and cisplatin resistance via regulating epithelial mesenchymal transition. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32363546&form=6&db=m COX-2-PGE2-EPs in gynecological cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32978284&form=6&db=m Repurposing [11C]PS13 for PET imaging of cyclooxygenase-1 (COX-1) in ovarian cancer xenograft mouse models. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33062161&form=6&db=m Targeted Detection of Cyclooxygenase-1 in Ovarian Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33209875&form=6&db=m Tanshinone IIA suppresses ovarian cancer growth through inhibiting malignant properties and angiogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34055228&form=6&db=m Development of Fluorescence Imaging Probes for Labeling COX-1 in Live Ovarian Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17767717&form=6&db=m The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18370716&form=6&db=m Effect of celecoxib, a cyclooxygenase-2-specific inhibitor, on insulin sensitivity, C-reactive protein, homocysteine, and metabolic profile in overweight or obese subjects. unassigned -
1.14.99.1 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19820230&form=6&db=m Neutrophil Infiltration and Systemic Vascular Inflammation in Obese Women. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22576212&form=6&db=m Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25125682&form=6&db=m NSAID use reduces breast cancer recurrence in overweight and obese women: role of prostaglandin-aromatase interactions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Overweight http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31800399&form=6&db=m Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities. unassigned -
1.14.99.1 Paget Disease, Extramammary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15327557&form=6&db=m Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Paget's Disease, Mammary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25735328&form=6&db=m Expression of Cox-2 and Bcl-2 in Paget's Disease of the Breast. causal interaction,unassigned 1,0
1.14.99.1 Pancreatic Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31009406&form=6&db=m Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Pancreatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15059431&form=6&db=m [Cyclooxygenase-2 gene expression in pancreatic disease] causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10070951&form=6&db=m Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10485483&form=6&db=m Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10597402&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10657949&form=6&db=m Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953335&form=6&db=m Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11180079&form=6&db=m Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11504793&form=6&db=m Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11586094&form=6&db=m Expression of inflammatory modulator COX-2 in pancreatic ductal adenocarcinoma and its relationship to pathologic and clinical parameters. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11781662&form=6&db=m Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920555&form=6&db=m Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020670&form=6&db=m Inflammation and the development of pancreatic cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12120207&form=6&db=m Cyclooxygenases and lipoxygenases as potential targets for treatment of pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12131767&form=6&db=m Cyclooxygenase-2 is overexpressed in chronic pancreatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164968&form=6&db=m Role of cyclooxygenase-2 and inducible nitric oxide synthase in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12384795&form=6&db=m The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499282&form=6&db=m Insulin-like growth factor-I antagonizes the antiproliferative effects of cyclooxygenase-2 inhibitors on BxPC-3 pancreatic cancer cells. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499915&form=6&db=m The selective cyclooxygenase-2 inhibitor nimesulide induces apoptosis in pancreatic cancer cells independent of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504222&form=6&db=m Selective cyclooxygenase-2 inhibitor rofecoxib (Vioxx) induces expression of cell cycle arrest genes and slows tumor growth in human pancreatic cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12533667&form=6&db=m Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12575899&form=6&db=m Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12774242&form=6&db=m Cyclo-oxygenase 2 inhibitors: emerging roles in the gut. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821125&form=6&db=m PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902862&form=6&db=m Initial experience combining cyclooxygenase-2 inhibition with chemoradiation for locally advanced pancreatic cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14517802&form=6&db=m Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14656949&form=6&db=m Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15087022&form=6&db=m [Effects of rofecoxib on angiogenesis of pancreatic cancer xenograft in nude mice] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15155137&form=6&db=m Emerging drugs in pancreatic cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15165031&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15316751&form=6&db=m Molecular targeting therapy for pancreatic cancer. causal interaction,unassigned 3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466186&form=6&db=m Gene expression profiling of tumor-stromal interactions between pancreatic cancer cells and stromal fibroblasts. therapeutic application,unassigned 3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15477758&form=6&db=m Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492268&form=6&db=m Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15542781&form=6&db=m Cyclooxygenase-2-dependent and -independent effects of celecoxib in pancreatic cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15660373&form=6&db=m Protease-activated receptor-2 regulates cell proliferation and enhances cyclooxygenase-2 mRNA expression in human pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685834&form=6&db=m Gemcitabine/Irinotecan/celecoxib in pancreatic cancer. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15705899&form=6&db=m Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15964750&form=6&db=m Effects of selective COX-2 and 5-LOX inhibition on prostaglandin and leukotriene synthesis in ductal pancreatic cancer in Syrian hamster. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15980665&form=6&db=m Cyclooxygenase-2 expression associated with severity of PanIN lesions: a possible link between chronic pancreatitis and pancreatic cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16060994&form=6&db=m [Enhancing effects of celecoxib on the growth inhibition of pancreatic carcinoma by gemcitabine treatment] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083499&form=6&db=m Pancreatic stellate cells (PSCs) express cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16110250&form=6&db=m Role of inflammation in pancreatic carcinogenesis and the implications for future therapy. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16319525&form=6&db=m Prostaglandin E(2) Drives Cyclooxygenase-2 Expression via Cyclic AMP Response Element Activation in Human Pancreatic Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16373709&form=6&db=m Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16467169&form=6&db=m Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16481301&form=6&db=m Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507392&form=6&db=m Curcumin synergistically potentiates the growth inhibitory and pro-apoptotic effects of celecoxib in pancreatic adenocarcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16759529&form=6&db=m [Detection of expression of p53, p16, and cyclooxygenase 2 in pancreatic cancer by tissue microarray and correlation among these three genes] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820089&form=6&db=m Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17172427&form=6&db=m Assessment of celecoxib pharmacodynamics in pancreatic cancer. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17343986&form=6&db=m Novel therapeutic approaches in the treatment of advanced pancreatic carcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369849&form=6&db=m Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17440100&form=6&db=m Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17541034&form=6&db=m Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584158&form=6&db=m Back to the future: COX-2 inhibitors for chemoprevention and cancer therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17592230&form=6&db=m Tumor size significantly correlates with postoperative liver metastases and COX-2 expression in patients with resectable pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17652141&form=6&db=m Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17882652&form=6&db=m Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17921715&form=6&db=m COX-2 and NF-KB overexpression is common in pancreatic cancer but does not predict for COX-2 inhibitors activity in combination with gemcitabine and oxaliplatin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,2
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17950526&form=6&db=m Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor (IGF-IR) system. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18000398&form=6&db=m Tumor COX-2 expression and prognosis of patients with resectable pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18361926&form=6&db=m Optimization of conditionally replicative adenovirus for pancreatic cancer and its evaluation in an orthotopic murine xenograft model. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18391600&form=6&db=m Gemcitabine plus celecoxib in patients with advanced or metastatic pancreatic adenocarcinoma: results of a phase II trial. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18437081&form=6&db=m Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth. ongoing research,unassigned 3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571585&form=6&db=m Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18577844&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses the growth of pancreatic cancer cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18615182&form=6&db=m The Role of PPAR-gamma and Its Interaction with COX-2 in Pancreatic Cancer. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617777&form=6&db=m Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18665070&form=6&db=m Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18815538&form=6&db=m Effect of celecoxib and the novel anti-cancer agent, dimethylamino-parthenolide, in a developmental model of pancreatic cancer. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19056168&form=6&db=m Inhibition of COX-2 and activation of peroxisome proliferator-activated receptor gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19062735&form=6&db=m [Association between single nucleotide polymorphisms in the promoter of cyclooxygenase COX-2 gene and hereditary susceptibility to pancreatic cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19346994&form=6&db=m Clinicopathological Correlations of Cyclooxygenase-2, MDM2, and p53 Expressions in Surgically Resectable Pancreatic Invasive Ductal Adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19422084&form=6&db=m Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20118820&form=6&db=m Vascular Endothelial Growth Factor and not Cyclooxygenase 2 Promotes Endothelial Cell Viability in the Pancreatic Tumor Microenvironment. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20213764&form=6&db=m Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20216081&form=6&db=m Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20397266&form=6&db=m Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20459551&form=6&db=m Expression of L1CAM, COX-2, EGFR, c-KIT and Her2/neu in anaplastic pancreatic cancer: putative therapeutic targets? causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530583&form=6&db=m Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20579221&form=6&db=m Knockdown of hTERT by SiRNA suppresses growth of Capan-2 human pancreatic cancer cell via the inhibition of expressions of Bcl-2 and COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20626589&form=6&db=m Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,3
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20739850&form=6&db=m HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21343834&form=6&db=m Cyclooxygenase-2 confers growth advantage to syngeneic pancreatic cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21408027&form=6&db=m Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer. causal interaction,unassigned 1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21705955&form=6&db=m Cyclooxygenase-2 Polymorphisms and Pancreatic Cancer Susceptibility. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21760774&form=6&db=m Involvement of COX-2/PGE(2) Pathway in the Upregulation of MMP-9 Expression in Pancreatic Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21935918&form=6&db=m Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. causal interaction,unassigned 3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21993002&form=6&db=m Enhancing antitumor effects in pancreatic cancer cells by combined use of COX-2 and 5-LOX inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22039326&form=6&db=m Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22200969&form=6&db=m The effects of cyclooxygenase-2 gene silencing by siRNA on cell proliferation, cell apoptosis, cell cycle and tumorigenicity of Capan-2 human pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22272632&form=6&db=m Prostaglandin E2 (PGE2) in portal blood in patients with pancreatic tumor--a single institution series. causal interaction,unassigned 4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22389271&form=6&db=m Correlation between Spiral CT Preoperative Staging of Pancreatic Cancer and PTEN and COX-2 Expression. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22784710&form=6&db=m Cell Intrinsic Role of Cox-2 in Pancreatic Cancer Development. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22829202&form=6&db=m Apricoxib, a Novel Inhibitor of COX-2, Markedly Improves Standard Therapy Response in Molecularly Defined Models of Pancreatic Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22955327&form=6&db=m Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agents. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23007878&form=6&db=m Biglycan expression and clinical outcome in patients with pancreatic adenocarcinoma. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23617255&form=6&db=m Combined treatment with PPAR-? agonists in pancreatic cancer: a glimmer of hope for cancer therapy? causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23658609&form=6&db=m Changes in cancer cell metabolism revealed by direct sample analysis with MALDI mass spectrometry. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23924856&form=6&db=m Triptolide induces apoptosis and inhibits the growth and angiogenesis of human pancreatic cancer cells by downregulating COX-2 and VEGF. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973710&form=6&db=m miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24040391&form=6&db=m The Anti-Tumor Effect of HDAC Inhibition in a Human Pancreas Cancer Model Is Significantly Improved by the Simultaneous Inhibition of Cyclooxygenase 2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24146280&form=6&db=m Cyclooxygenase 2 promoted the tumorigenecity of pancreatic cancer cells. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24212630&form=6&db=m Experimental animal models of pancreatic carcinogenesis for prevention studies and their relevance to human disease. causal interaction,unassigned 4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24424498&form=6&db=m Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-?B signaling by 6-shogaol. therapeutic application,unassigned 2,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24647860&form=6&db=m A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24912820&form=6&db=m Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25034525&form=6&db=m Prognostic significance of cyclooxygenase-2 protein in pancreatic cancer: a meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25152576&form=6&db=m Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25152585&form=6&db=m Novel therapeutic targets for pancreatic cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25628848&form=6&db=m Direct Sequencing of Cyclooxygenase-2 (COX-2) Revealed an Intronic Variant rs201231411 in Iranian Patients with Pancreatic Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25642980&form=6&db=m 5-Lipoxygenase and Cyclooxygenase inhibitory Dammarane triterpenoid 1 from Borassus flabellifer seed coat, inhibits Tumor Necrosis Factor-? secretion in LPS induced THP-1 human monocytes and induces apoptosis in MIA PaCa-2 Pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25949900&form=6&db=m Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against ?? T cell cytotoxicity. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973062&form=6&db=m Anti-tumor effect and mechanism of cyclooxygenase-2 inhibitor through matrix metalloproteinase 14 pathway in PANC-1 cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26035123&form=6&db=m Mucin 1 Regulates Cox-2 Gene in Pancreatic Cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26550156&form=6&db=m Cyclooxygenase-2 -1195G>A (rs689466) polymorphism and cancer susceptibility: an updated meta-analysis involving 50,672 subjects. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26605280&form=6&db=m Pancreatic cancer and thromboembolic disease, 150 years after Trousseau. causal interaction,unassigned 3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26675757&form=6&db=m HuR mediated post-transcriptional regulation as a new potential adjuvant therapeutic target in chemotherapy for pancreatic cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,2
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691217&form=6&db=m Upregulation of cugbp2 increases response of pancreatic cancer cells to chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,2
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27301888&form=6&db=m Retraction: "Concurrent inhibition of NF-?B, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer" by Ali et al. diagnostic usage,unassigned 1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27368132&form=6&db=m Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ?-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27430377&form=6&db=m Celecoxib suppresses fibroblast growth factor-2 expression in pancreatic ductal adenocarcinoma PANC-1 cells. causal interaction,unassigned 1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28260499&form=6&db=m Regulatory role of G protein-coupled receptors in pancreatic cancer development and progression. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28352075&form=6&db=m Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic Cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28815606&form=6&db=m Prospective study of urinary prostaglandin E2 metabolite and pancreatic cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29587668&form=6&db=m Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29896263&form=6&db=m Nimesulide inhibits proliferation and induces apoptosis of pancreatic cancer cells by enhancing expression of PTEN. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29942156&form=6&db=m Comparison of NSAIDs activity in COX-2 expressing and non-expressing 2D and 3D pancreatic cancer cell cultures. unassigned -
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29963167&form=6&db=m Cyclooxygenase-2 induces angiogenesis in pancreatic cancer mediated by prostaglandin E2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30254182&form=6&db=m Cyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30333153&form=6&db=m Cyclooxygenase-2 Inhibition Potentiates the Efficacy of Vascular Endothelial Growth Factor Blockade and Promotes an Immune Stimulatory Microenvironment in Preclinical Models of Pancreatic Cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32277667&form=6&db=m Relationships of pain in pancreatic cancer patients with pathological stage and expressions of NF-?B and COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,2
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33230429&form=6&db=m EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33632872&form=6&db=m PGE2 Released by Pancreatic Cancer Cells Undergoing ER Stress Transfers the Stress to DCs Impairing Their Immune Function. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34175402&form=6&db=m Bioinformatic mining and validation of the effects of ferroptosis regulators on the prognosis and progression of pancreatic adenocarcinoma. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Pancreaticobiliary Maljunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12579269&form=6&db=m Immunohistochemical analysis of cyclooxygenase-2 and vascular endothelial growth factor in pancreaticobiliary maljunction. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Pancreaticobiliary Maljunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12717864&form=6&db=m Bile from a patient with anomalous pancreaticobiliary ductal union promotes the proliferation of human cholangiocarcinoma cells via COX-2 pathway. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Pancreaticobiliary Maljunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15161010&form=6&db=m Different expression of cyclooxygenase-2 in biliary epithelia of bile duct cancer with or without pancreaticobiliary maljunction. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Pancreaticobiliary Maljunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20651971&form=6&db=m Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery. unassigned -
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6628928&form=6&db=m Effects of prostaglandin and indomethacin on diet-induced acute pancreatitis in mice. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10558906&form=6&db=m Cyclooxygenase-2 transcription is stimulated and amylase secretion is inhibited in pancreatic acinar cells after induction of acute pancreatitis. causal interaction,unassigned 3,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12131767&form=6&db=m Cyclooxygenase-2 is overexpressed in chronic pancreatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12360491&form=6&db=m Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12381531&form=6&db=m Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12774242&form=6&db=m Cyclo-oxygenase 2 inhibitors: emerging roles in the gut. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12846004&form=6&db=m Selective inhibition of cyclooxygenase-2 (COX-2) reduces prostaglandin E2 production and attenuates systemic disease sequelae in experimental pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14751415&form=6&db=m Inhibition of cyclooxygenase-2 reduces the protective effect of hepatocyte growth factor in experimental pancreatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15120378&form=6&db=m COX-2 inhibition results in alterations in nuclear factor (NF)-kappaB activation but not cytokine production in acute pancreatitis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15140659&form=6&db=m Effect of inducible cyclooxygenase expression on local microvessel blood flow in acute interstitial pancreatitis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15237442&form=6&db=m Role of COX-2 in microcirculatory disturbance in experimental pancreatitis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15730936&form=6&db=m Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16273606&form=6&db=m Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,2
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16924320&form=6&db=m Inhibition of cyclooxygenase-2 in experimental severe acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16995470&form=6&db=m Effects of dual inhibitor of cyclooxygenase and 5-lipoxygenase on acute necrotizing pancreatitis in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441341&form=6&db=m [Role of cyclooxygenase-2 in pulmonary microcirculation disorder in rats with acute pancreatitis] causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17511027&form=6&db=m Selective cyclooxygenase-2 inhibitor ameliorates cholecystokinin-octapeptide-induced acute pancreatitis in rats. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17513789&form=6&db=m IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappa B activation. therapeutic application,unassigned 2,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17925765&form=6&db=m [Acute pancreatitis after treatment by celecoxib.] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19027919&form=6&db=m Ethyl pyruvate ameliorates liver injury secondary to severe acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19820421&form=6&db=m The Effect of Genetic Polymorphisms of Cyclooxygenase 2 on Acute Pancreatitis in Turkey. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20531057&form=6&db=m A possible case of saw palmetto-induced pancreatitis. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20977452&form=6&db=m Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21372163&form=6&db=m COX-2 is not required for the development of murine chronic pancreatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22955327&form=6&db=m Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agents. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25803032&form=6&db=m Smad4 loss synergizes with TGF? overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis. diagnostic usage,unassigned 1,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26610611&form=6&db=m Intestinal barrier dysfunction and increased COX-2 gene expression in the gut of elderly rats with acute pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28171691&form=6&db=m Toward routine use of nonsteroidal anti-inflammatory drugs for patients undergoing endoscopic retrograde cholangiopancreatography. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28697127&form=6&db=m Celecoxib Oral Administration for Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Randomized Prospective Trial. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32064683&form=6&db=m Nonsteroidal anti-inflammatory drugs alleviate severity of post-endoscopic retrograde cholangiopancreatography pancreatitis by inhibiting inflammation and reducing apoptosis. therapeutic application,unassigned 4,0
1.14.99.1 Pancreatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32142484&form=6&db=m Prevention of Severe Acute Pancreatitis With Cyclooxygenase-2 Inhibitors: A Randomized Controlled Clinical Trial. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pancreatitis, Acute Hemorrhagic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8388115&form=6&db=m Cyclooxygenase and lipoxygenase metabolism in sodium taurocholate induced acute hemorrhagic pancreatitis in rats. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Pancreatitis, Acute Necrotizing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16995470&form=6&db=m Effects of dual inhibitor of cyclooxygenase and 5-lipoxygenase on acute necrotizing pancreatitis in rats. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11842281&form=6&db=m Cyclooxygenase 2 expression in chronic pancreatitis: correlation with stage of the disease and diabetes mellitus. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11920515&form=6&db=m Immunohistochemical analysis and in situ hybridization of cyclooxygenase-2 expression in intraductal papillary-mucinous tumors of the pancreas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12131767&form=6&db=m Cyclooxygenase-2 is overexpressed in chronic pancreatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15980665&form=6&db=m Cyclooxygenase-2 expression associated with severity of PanIN lesions: a possible link between chronic pancreatitis and pancreatic cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322109&form=6&db=m A selective COX-2 inhibitor suppresses chronic pancreatitis in an animal model (WBN/Kob rats): significant reduction of macrophage infiltration and fibrosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16837651&form=6&db=m Cyclooxygenase-2 is required for activated pancreatic stellate cells to respond to proinflammatory cytokines. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17916652&form=6&db=m Prostaglandin E2 modulates TNF-alpha-induced MCP-1 synthesis in pancreatic acinar cells in a PKA-dependent manner. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21372163&form=6&db=m COX-2 is not required for the development of murine chronic pancreatitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Pancreatitis, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30431318&form=6&db=m Transgenic expression of cyclooxygenase-2 in pancreatic acinar cells induces chronic pancreatitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7818763&form=6&db=m Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766436&form=6&db=m Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10401857&form=6&db=m Characterization of cyclooxygenase in laryngeal papilloma by molecular techniques. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10590224&form=6&db=m Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162632&form=6&db=m Ultraviolet B(UVB)-induced cox-2 expression in murine skin: an immunohistochemical study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11245450&form=6&db=m Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086405&form=6&db=m Is cyclooxygenase-2 important in skin carcinogenesis? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12115530&form=6&db=m Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor kappa B activation in mouse skin. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126310&form=6&db=m Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12151359&form=6&db=m Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16144915&form=6&db=m Epidermal growth factor-induced cyclooxygenase-2 expression is mediated through phosphatidylinositol-3 kinase, not mitogen-activated protein/extracellular signal-regulated kinase kinase, in recurrent respiratory papillomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16621493&form=6&db=m Elevated prostaglandin E2 level via cPLA2--COX-2--mPGES-1 pathway involved in bladder carcinogenesis induced by terephthalic acid-calculi in Wistar rats. diagnostic usage,unassigned 4,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17177839&form=6&db=m The expression of epidermal growth factor receptor, vascular endothelial growth factor, matrix metalloproteinase-2, and cyclooxygenase-2 in relation to human papilloma viral load and persistence of human papillomavirus after conization with negative margins. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17234720&form=6&db=m Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437488&form=6&db=m The expression pattern of prostaglandin E synthase and EP receptor isoforms in normal mouse skin and preinvasive skin neoplasms. ongoing research,unassigned 4,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17592548&form=6&db=m Up-regulation of Rac1 by epidermal growth factor mediates COX-2 expression in recurrent respiratory papillomas. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18266822&form=6&db=m Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18848748&form=6&db=m Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-kappaB and C/EBP as potential targets. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,3
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19005325&form=6&db=m Recurrent respiratory papillomatosis: update 2008. therapeutic application,unassigned 4,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19627000&form=6&db=m [The expressions of PPAR-gamma, COX-2 in the lesions of patients with condyloma acuminatum and bowenoid papulosis] unassigned -
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19736197&form=6&db=m Regression of recurrent respiratory papillomatosis with celecoxib and erlotinib combination therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19771276&form=6&db=m Inhibition of Phorbol Ester-induced Mouse Skin Tumor Promotion and COX-2 Expression by Celecoxib: C/EBP as a Potential Molecular Target. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20131316&form=6&db=m Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20564344&form=6&db=m 3,3'-diindolylmethane suppresses 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and tumor promotion in mouse skin via the downregulation of inflammatory mediators. therapeutic application,unassigned 2,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20599447&form=6&db=m Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fate. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22113496&form=6&db=m Constitutive Overexpression of the Oncogene Rac1 in the Airway of Recurrent Respiratory Papillomatosis Patients is a Targetable Host-Susceptibility Factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22135046&form=6&db=m The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203921&form=6&db=m Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesions. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22902545&form=6&db=m Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23031678&form=6&db=m Tissue biomarkers as prognostic variables of cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23457529&form=6&db=m Altered prostanoid signaling contributes to increased skin tumorigenesis in tpl2 knockout mice. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23879794&form=6&db=m Expression of COX-1, COX-2 and mPGES-1 in penile and preputial papillomas and squamous cell carcinomas in the horse. diagnostic usage,unassigned 3,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469308&form=6&db=m Cell-type-specific roles for COX-2 in UVB-induced skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27882174&form=6&db=m Reduction of p38 mitogen-activated protein kinase and cyclooxygenase-2 signaling by isoflurane inhibits proliferation and apoptosis evasion in human papillomavirus-infected laryngeal papillomas. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30270026&form=6&db=m Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer. ongoing research,unassigned 3,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32138838&form=6&db=m Avian Papilloma and Squamous Cell Carcinoma: a Histopathological, Immunohistochemical and Virological study. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32658799&form=6&db=m Juvenile recurrent respiratory papillomatosis treated with combined erlotinib and celecoxib: Initial report. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32664608&form=6&db=m Are FDA-Approved Sunscreen Components Effective in Preventing Solar UV-Induced Skin Cancer? causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33343991&form=6&db=m COX-2 Overexpression in Schneiderian Papillomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Papilloma, Intraductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12926055&form=6&db=m Expression of cyclooxygenase-2 in malignant and benign breast tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Papilloma, Inverted http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534023&form=6&db=m Pattern of expression of cyclooxygenase-2 in malignant transformation of sinonasal inverted papilloma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Papilloma, Inverted http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22951321&form=6&db=m Inflammation and apoptosis in malignant transformation of sinonasal inverted papilloma: the role of the bridge molecules, cyclooxygenase-2, and nuclear factor ?B. causal interaction,unassigned 3,0
1.14.99.1 Papilloma, Inverted http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24106179&form=6&db=m COX-2 overexpression in sinonasal inverted papilloma. unassigned -
1.14.99.1 Papilloma, Inverted http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25980147&form=6&db=m [Significances of COX-2, p21, Ki-67 expression and HPV infection in nasal inverted papilloma]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12516959&form=6&db=m Deregulated cyclooxygenase-2 expression in oral premalignant tissues. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18773440&form=6&db=m Increased detection of clue cells in smears from cervical intraepithelial lesions with reduced expression of COX-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424030&form=6&db=m Immunohistochemical evaluation of COX-2 expression in HPV-positive cervical squamous intraepithelial lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22113496&form=6&db=m Constitutive Overexpression of the Oncogene Rac1 in the Airway of Recurrent Respiratory Papillomatosis Patients is a Targetable Host-Susceptibility Factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22203921&form=6&db=m Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesions. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24374907&form=6&db=m Comprehensive analysis of HPV expression in laryngeal squamous cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24831259&form=6&db=m Expression of Human Papillomavirus is Correlated with Ki-67 and COX-2 Expressions in Keratocystic Odontogenic Tumor. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Papillomavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25980147&form=6&db=m [Significances of COX-2, p21, Ki-67 expression and HPV infection in nasal inverted papilloma]. diagnostic usage,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Paraganglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27357268&form=6&db=m HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Paraganglioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31142060&form=6&db=m Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20121401&form=6&db=m Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Paramyxoviridae Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31022559&form=6&db=m Original research article Parainfluenza virus infection enhances NSAIDs-induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Paraplegia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609232&form=6&db=m A potential protective effect of alpha-tocopherol on vascular complication in spinal cord reperfusion injury in rats. causal interaction,unassigned 4,0
1.14.99.1 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8906742&form=6&db=m Lymphocyte muscarinic cholinergic activity and PGE2 involvement in experimental Trypanosoma cruzi infection. therapeutic application,unassigned 4,0
1.14.99.1 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15019517&form=6&db=m Effects of eicosanoid biosynthesis inhibitors on the prophenoloxidase-activating system and microaggregation reactions in the hemolymph of Rhodnius prolixus infected with Trypanosoma rangeli. therapeutic application,unassigned 4,0
1.14.99.1 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619186&form=6&db=m Suppression of Prostaglandin E2 by Malaria Parasite Products and Antipyretics Promotes Overproduction of Tumor Necrosis Factor- alpha : Association with the Pathogenesis of Childhood Malarial Anemia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19910682&form=6&db=m Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Parasitemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21347238&form=6&db=m Aspirin treatment of mice infected with Trypanosoma cruzi and implications for the pathogenesis of Chagas disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15172219&form=6&db=m Entamoeba histolytica: induction of cyclooxygenase-2 expression during amoebic liver abscess formation in hamsters (Mesocricetus auratus). causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15893125&form=6&db=m Will corticosteroids and other anti-inflammatory agents be effective for diarrhea-predominant irritable bowel syndrome? therapeutic application,unassigned 3,0
1.14.99.1 Parasitic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28684424&form=6&db=m IL-4 up-regulates cyclooxygenase-1 expression in macrophages. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Paratuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366713&form=6&db=m Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7830086&form=6&db=m Enzymatic oxidation of dopamine: the role of prostaglandin H synthase. causal interaction,unassigned 4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11180504&form=6&db=m Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12702778&form=6&db=m Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration. causal interaction,unassigned 3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12846993&form=6&db=m COX-2 and neurodegeneration in Parkinson's disease. unassigned -
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561922&form=6&db=m COX-2-deficient mice are less prone to MPTP-neurotoxicity than wild-type mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14645986&form=6&db=m Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14704277&form=6&db=m JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. unassigned -
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15285796&form=6&db=m Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15331118&form=6&db=m Mechanism of age-associated up-regulation in macrophage PGE2 synthesis. causal interaction,unassigned 4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845609&form=6&db=m MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15931668&form=6&db=m Dopaminergic neurotoxicity by 6-OHDA and MPP+: differential requirement for neuronal cyclooxygenase activity. causal interaction,unassigned 4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16041799&form=6&db=m Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease. unassigned -
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16566823&form=6&db=m Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16712820&form=6&db=m Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells. causal interaction,unassigned 3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17073683&form=6&db=m Imaging of cyclooxygenase-2 (COX-2) expression: potential use in diagnosis and drug evaluation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17171651&form=6&db=m Cyclooxygenase-2 polymorphisms in Parkinson's disease. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17320073&form=6&db=m The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560944&form=6&db=m Role of cyclooxygenase-2 in tetrahydrobiopterin-induced dopamine oxidation. causal interaction,unassigned 3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17715026&form=6&db=m [Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson disease] ongoing research,unassigned 3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868147&form=6&db=m PGE(2) receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE(2) neurotoxicity. causal interaction,unassigned 2,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17901552&form=6&db=m Function of COX-2 and prostaglandins in neurological disease. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18403118&form=6&db=m Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. causal interaction,unassigned 1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18612814&form=6&db=m The effects of piroxicam in the attenuation of MPP+/MPTP toxicity in vitro and in vivo. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18819875&form=6&db=m [Ginsenoside Rg1 modulates COX-2 expression in the substantia nigra of mice with MPTP-induced Parkinson disease through the P38 signaling pathway.] causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19604516&form=6&db=m JNK inhibitor protects dopaminergic neurons by reducing COX-2 expression in the MPTP mouse model of subacute Parkinson's disease. unassigned -
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19616617&form=6&db=m Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease. causal interaction,unassigned 4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19666045&form=6&db=m Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats. ongoing research,unassigned 2,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19861252&form=6&db=m [P38MAPK pathway regulates COX-2 and caspase-3 expression in a mouse model of Parkinson disease.] diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19997776&form=6&db=m Brain arachidonic acid cascade enzymes are upregulated in a rat model of unilateral Parkinson disease. causal interaction,unassigned 3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20087233&form=6&db=m The effect of repetitive transcranial magnetic stimulation on a model rat of Parkinson's disease. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20166930&form=6&db=m Progress in COX-2 inhibitors: a journey so far. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20808546&form=6&db=m Cyclooxygenase and neuroinflammation in Parkinson's disease neurodegeneration. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20851755&form=6&db=m Paraquat induces cyclooxygenase-2 (COX-2) implicated toxicity in human neuroblastoma SH-SY5Y cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20882760&form=6&db=m Effect of preferential cyclooxygenase-2 (COX-2) inhibitor against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal lesions in rats: behavioral, biochemical and histological evidences. causal interaction,unassigned 4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21174803&form=6&db=m [The effect of cyclooxygenase-2 on dopaminergic neurons in substantia nigra of Parkinson's disease mice induced by MPTP]. ongoing research,unassigned 4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21234736&form=6&db=m The Effect of Docosahexaenoic Acid on Visual Evoked Potentials in a Mouse Model of Parkinson's Disease: The Role of Cyclooxygenase-2 and Nuclear Factor Kappa-B. ongoing research,unassigned 2,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22826171&form=6&db=m COX-2 in the neurodegenerative process of Parkinson's disease. causal interaction,unassigned 3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22940226&form=6&db=m The effect of guggulipid and nimesulide on MPTP-induced mediators of neuroinflammation in rat astrocytoma cells, C6. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23695225&form=6&db=m The role of ?-adrenergic blockers in Parkinson's disease: possible genetic and cell-signaling mechanisms. unassigned -
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24360742&form=6&db=m Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease. therapeutic application,unassigned 1,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24381603&form=6&db=m The selective cyclooxygenase-2 inhibitor, the compound 11b improves haloperidol induced catatonia by enhancing the striatum dopaminergic neurotransmission. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25263280&form=6&db=m Mechanism of the beneficial effect of melatonin in experimental Parkinson's disease. ongoing research,unassigned 3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26009769&form=6&db=m Are cyclooxygenase-2 and nitric oxide involved in the dyskinesia of Parkinson's disease induced by L-DOPA? causal interaction,unassigned 3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328537&form=6&db=m Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722563&form=6&db=m Genetic association of cyclooxygenase-2 gene polymorphisms with Parkinson's disease susceptibility in Chinese Han population. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26748744&form=6&db=m Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29150878&form=6&db=m Cyclooxygenase 2 is upregulated in the gastrointestinal tract in Parkinson's disease. causal interaction,unassigned 4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29169114&form=6&db=m Evaluation of antiparkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS/MS method development. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29498006&form=6&db=m Inhibition of Cyclooxygenase-2 (COX-2) Initiates Autophagy and Potentiates MPTP-Induced Autophagic Cell Death of Human Neuroblastoma Cells, SH-SY5Y: an Inside in the Pathology of Parkinson's Disease. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30236122&form=6&db=m Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. causal interaction,unassigned 4,0
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30475154&form=6&db=m Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells. unassigned -
1.14.99.1 Parkinson Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16781689&form=6&db=m Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats. ongoing research,unassigned 2,0
1.14.99.1 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18403118&form=6&db=m Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. causal interaction,unassigned 1,0
1.14.99.1 Parkinsonian Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28290146&form=6&db=m Cyclooxygenase-2 Directs Microglial Activation-Mediated Inflammation and Oxidative Stress Leading to Intrinsic Apoptosis in Zn-Induced Parkinsonism. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Paroxysmal Hemicrania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15096232&form=6&db=m Seasonal episodic paroxysmal hemicrania responding to cyclooxygenase-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Paroxysmal Hemicrania http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21284612&form=6&db=m Hemicrania continua changed to chronic paroxysmal hemicrania after treatment with cyclooxygenase-2 inhibitor. therapeutic application,unassigned 3,0
1.14.99.1 Pelvic Inflammatory Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33927776&form=6&db=m Study on the Bioassay of Anti-Inflammatory Effects of Fuke Qianjin Capsule Based on COX-2 Inhibiting Activity. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Penile Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18587553&form=6&db=m [Value of targeted therapy for penile cancer.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1765987&form=6&db=m The therapeutic approaches of community based primary care practitioners to osteoarthritis of the hip in an elderly patient. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7557077&form=6&db=m Risk factors associated with refractory peptic ulcers. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9349689&form=6&db=m Inhibition of cyclooxygenase: a novel approach to cancer prevention. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10533511&form=6&db=m When to try COX-2-specific inhibitors. Safer than standard NSAIDs in some situations. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10580458&form=6&db=m Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. therapeutic application,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10581086&form=6&db=m Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. unassigned -
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10628590&form=6&db=m Pharmacology and efficacy of cyclooxygenase (COX) inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10693877&form=6&db=m Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial. The Rofecoxib Osteoarthritis Endoscopy Multinational Study Group. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10901773&form=6&db=m Clinical manifestations of gout and their management. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11053009&form=6&db=m Time course inhibition of gastric and platelet COX activity by acetylsalicylic acid in humans. unassigned -
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11177775&form=6&db=m COX-2 inhibitors in rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11316141&form=6&db=m Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12187755&form=6&db=m [Treatment of peptic ulcer related to rheumatic diseases] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12395741&form=6&db=m [Anti-inflammatory non-steroidal selective cyclooxygenase 2 inhibitors and gastroduodenal lesions] causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12831509&form=6&db=m Gastrointestinal mucosal injury following repeated daily oral administration of conventional formulations of indometacin and other non-steroidal anti-inflammatory drugs to pigs: a model for human gastrointestinal disease. unassigned -
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12942226&form=6&db=m "Selective" switching from non-selective to selective non-steroidal anti-inflammatory drugs. causal interaction,unassigned 2,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529400&form=6&db=m Gastroduodenal safety of cyclooxygenase-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529403&form=6&db=m COX-2 inhibition versus gastroprotection with dual COX inhibitors: an evidence-based approach. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14531897&form=6&db=m Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. causal interaction,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693324&form=6&db=m Determinants of selective cyclooxygenase-2 inhibitor prescribing: are patient or physician characteristics more important? causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15038104&form=6&db=m [Are COX-2 inhibitors truly able to prevent NSAIDs-associated ulcer?] causal interaction,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15050982&form=6&db=m Cyclooxygenase-2 specific inhibitors in the treatment of dysmenorrhea. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15338504&form=6&db=m Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis. therapeutic application,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15771318&form=6&db=m [From PICO to search terms on the Internet: how to find relevant information? New coxibs: do they have a better gastrointestinal safety?] diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15892675&form=6&db=m Gastrointestinal effects of selective and non-selective non-steroidal anti-inflammatory drugs. therapeutic application,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16271912&form=6&db=m Celecoxib compared with lansoprazole and naproxen to prevent gastrointestinal ulcer complications. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16750449&form=6&db=m A multicenter, randomized, double-blind, active-comparator, placebo-controlled, parallel-group comparison of the incidence of endoscopic gastric and duodenal ulcer rates with valdecoxib or naproxen in healthy subjects aged 65 to 75 years. causal interaction,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16817839&form=6&db=m Prevention of NSAID-associated gastrointestinal lesions: a comparison study pantoprazole versus omeprazole. unassigned -
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17078001&form=6&db=m Effect of a specific cyclooxygenase-gene polymorphism (A-842G/C50T) on the occurrence of peptic ulcer hemorrhage. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671743&form=6&db=m Association between genetic polymorphisms in the cyclooxygenase-1 gene promoter and peptic ulcers in Japan. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17916545&form=6&db=m Celecoxib plus aspirin versus naproxen and lansoprazole plus aspirin: a randomized, double-blind, endoscopic trial. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18330937&form=6&db=m Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: A study from northern India. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18346679&form=6&db=m Epidemiology of acute upper gastrointestinal bleeding. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18346690&form=6&db=m Future expectations in the prophylaxis of intestinal bleeding. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18381949&form=6&db=m The potential predictive value of cyclooxygenase-2 expression and increased risk of gastrointestinal hemorrhage in advanced non-small cell lung cancer patients treated with erlotinib and celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,2
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18628177&form=6&db=m Supportive care of elderly patients with cancer. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18711705&form=6&db=m Hospitalization for peptic ulcer and bleeding in users of selective COX-2 inhibitors and nonselective NSAIDs with special reference to celecoxib. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18783518&form=6&db=m Helicobacter pylori and non-malignant diseases. therapeutic application,unassigned 1,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18823646&form=6&db=m Nonsteroidal Anti-Inflammatory Drugs: Adverse Effects and Their Prevention. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19148794&form=6&db=m Cyclooxygenase-2 inhibitors in patients with high gastrointestinal risk: are we there yet? causal interaction,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680014&form=6&db=m Nonsteroidal antiinflammatory drugs and cyclooxygenase inhibition in the gastrointestinal tract: a trip from peptic ulcer to colon cancer. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19934612&form=6&db=m [Guidelines of prevention and treatment for NSAID-related peptic ulcers] therapeutic application,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20586862&form=6&db=m Aspirin-induced peptic ulcer and genetic polymorphisms. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20678677&form=6&db=m Incidence and possible risk factors for clinical upper gastrointestinal events in patients taking selective cyclooxygenase-2 inhibitors: A prospective, observational, cohort study in Taiwan. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20695843&form=6&db=m Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats. therapeutic application,unassigned 3,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20948372&form=6&db=m NSAID-induced gastrointestinal and cardiovascular injury. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21061542&form=6&db=m [A genetic background of ulcer diseases induced by NSAID/aspirin]. causal interaction,unassigned 2,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21688615&form=6&db=m [Low-dose aspirin (LDA)/nonsteroidal anti-inflammatory drugs(NSAIDs)-induced gastrointestinal injury in Japan]. therapeutic application,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23460386&form=6&db=m Adherence to the preventive strategies for nonsteroidal anti-inflammatory drug- or low-dose aspirin-induced gastrointestinal injuries. therapeutic application,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24833939&form=6&db=m COX-2 Gene Promoter Methylation in Patients Infected with Helicobacter Pylori. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25243161&form=6&db=m Impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25284702&form=6&db=m Gastroprotective agent underuse in high-risk older daily nonsteroidal anti-inflammatory drug users over time. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26369686&form=6&db=m Low-Dose Aspirin-Associated Upper and Mid Gastrointestinal Tract Damage and Gene Polymorphism. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26601827&form=6&db=m The IL-1B Genetic Polymorphism Is Associated with Aspirin-Induced Peptic Ulcers in a Korean Ethnic Group. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449186&form=6&db=m The risk of lower gastrointestinal bleeding in low-dose aspirin users. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29948304&form=6&db=m A case-control study of the risk of upper gastrointestinal mucosal injuries in patients prescribed concurrent NSAIDs and antithrombotic drugs based on data from the Japanese national claims database of 13 million accumulated patients. therapeutic application,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30366771&form=6&db=m Risk factors for upper gastrointestinal bleeding among aspirin users: An old issue with new findings from a population-based cohort study. causal interaction,unassigned 4,0
1.14.99.1 Peptic Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31937550&form=6&db=m Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Peptic Ulcer Perforation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807404&form=6&db=m Induction of cyclooxygenase-2 in mesothelial cells in peritonitis caused by perforated ulcers--an immunohistochemical study in humans. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Peptic Ulcer Perforation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17026569&form=6&db=m 30-day mortality after peptic ulcer perforation among users of newer selective COX-2 inhibitors and traditional NSAIDs: a population-based study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Peri-Implantitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31746655&form=6&db=m Histological evaluation of peri-implant mucosal and gingival tissues in peri-implantitis, peri-implant mucositis and periodontitis patients: a cross-sectional clinical study. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Peri-Implantitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31853997&form=6&db=m Long non-coding RNA and mRNA expression profiles in peri-implantitis vs periodontitis. diagnostic usage,unassigned 3,0
1.14.99.1 Peri-Implantitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31929206&form=6&db=m PPAR-?, RXR, VDR, and COX-2 Expressions in gingival tissue samples of healthy individuals, periodontitis and peri-implantitis patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Periapical Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17940572&form=6&db=m [Expression of cyclooxygenase 2 mRNA in apical periodontitis.] causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Periapical Granuloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30477664&form=6&db=m Immunohistochemical Analysis of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha in Periapical Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Periapical Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17940572&form=6&db=m [Expression of cyclooxygenase 2 mRNA in apical periodontitis.] causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Periapical Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31166414&form=6&db=m Periapical bone response to bacterial lipopolysaccharide is shifted upon cyclooxygenase blockage. unassigned -
1.14.99.1 Periapical Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33403674&form=6&db=m Celecoxib treatment dampens LPS-induced periapical bone resorption in a mouse model. therapeutic application,unassigned 4,0
1.14.99.1 Periarthritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15324530&form=6&db=m Oxaprozin: kinetic and dynamic profile in the treatment of pain. therapeutic application,unassigned 3,0
1.14.99.1 Perinatal Death http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9751758&form=6&db=m Opposing actions of prostaglandins and oxytocin determine the onset of murine labor. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3455946&form=6&db=m The effects of a topically-active non-steroidal anti-inflammatory drug on ligature-induced periodontal disease in the squirrel monkey. ongoing research,unassigned 3,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3969553&form=6&db=m Flurbiprofen: a potent inhibitor of alveolar bone resorption in beagles. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8894718&form=6&db=m Prostaglandin production via induction of cyclooxygenase-2 by human gingival fibroblasts stimulated with lipopolysaccharides. unassigned -
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9660336&form=6&db=m Induction of COX-2 expression by mechanical tension force in human periodontal ligament cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10476899&form=6&db=m Involvement of cyclooxygenase-2 in interleukin-1alpha-induced prostaglandin production by human periodontal ligament cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10769133&form=6&db=m Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. causal interaction,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10914805&form=6&db=m Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11327079&form=6&db=m Involvement of cyclooxygenase-2 in serum-induced prostaglandin production by human oral gingival epithelial cells. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11850029&form=6&db=m Enhancement of lipopolysaccharide-stimulated cyclooxygenase-2 mRNA expression and prostaglandin E2 production in gingival fibroblasts from individuals with Down syndrome. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12593599&form=6&db=m Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis. unassigned -
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12941074&form=6&db=m Induction of cyclooxygenase-2 mRNA and protein expression in human gingival fibroblasts stimulated with nicotine. causal interaction,unassigned 3,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16539839&form=6&db=m Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. causal interaction,unassigned 2,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16896836&form=6&db=m Effect of meloxicam on gingival crevicular fluid IL-1beta and IL1 receptor antagonist levels in subjects with chronic periodontitis, and its effects on clinical parameters. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17051959&form=6&db=m [The role of COX-2 in dentistry. Past or future?] therapeutic application,unassigned 4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17214837&form=6&db=m The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal disease. unassigned -
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18520044&form=6&db=m Preventive effects of a Kampo medicine, Shosaikoto, on inflammatory responses in LPS-treated human gingival fibroblasts. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18533784&form=6&db=m COX-2 inhibition decreases VEGF expression and alveolar bone loss during the progression of experimental periodontitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18948273&form=6&db=m Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19180322&form=6&db=m Short-term effect of COX-2 selective inhibitor as an adjunct for the treatment of periodontal disease: a clinical double-blind study in humans. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19210344&form=6&db=m Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960064&form=6&db=m Treatment of experimental periodontal disease by a selective inhibitor of cyclooxygenase-2 with scaling and root planing (SRP). causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22324469&form=6&db=m Cox-2 Expression in Gingival Biopsies From Periodontal Patients is Correlated With Connective Tissue Loss. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22545218&form=6&db=m Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23095809&form=6&db=m Involvement of the P2X7 purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E2 induction by LL-37. causal interaction,unassigned 3,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23392729&form=6&db=m Endotoxins potentiate COX-2 and RANKL expression in compressed PDL cells. ongoing research,unassigned 3,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24744546&form=6&db=m Comparative evaluation of the efficacy of the cyclooxygenase pathway inhibitor and nitric oxide synthase inhibitor in the reduction of alveolar bone loss in ligature induced periodontitis in rats: An experimental study. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25352713&form=6&db=m Assessment of Alloxan-Induced Diabetic Rats as a Periodontal Disease Model Using a Selective Cyclooxygenase (COX)-2 Inhibitor. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26291983&form=6&db=m ?-Glucans (Saccharomyces cereviseae) Reduce Glucose Levels and Attenuate Alveolar Bone Loss in Diabetic Rats with Periodontal Disease. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743292&form=6&db=m Cyclooxygenase-2 and matrix metalloproteinase-9 expressions correlate with tissue inflammation degree in periodontal disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28736819&form=6&db=m Evaluation of DNA methylation of inflammatory genes following treatment of chronic periodontitis: A pilot case-control study. therapeutic application,unassigned 3,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29147213&form=6&db=m Topical Application of Hangeshashinto (TJ-14) in the Treatment of Chemotherapy-Induced Oral Mucositis. therapeutic application,unassigned 1,0
1.14.99.1 Periodontal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30970055&form=6&db=m Effects of Selective Versus Non-Selective COX-2 Inhibition on Experimental Periodontitis. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1608034&form=6&db=m Effects of NSAIDs on beagle crevicular cyclooxygenase metabolites and periodontal bone loss. ongoing research,unassigned 3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2524572&form=6&db=m Changes in cyclooxygenase metabolites in experimental periodontitis in Macaca mulatta. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10914805&form=6&db=m Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12005261&form=6&db=m Evidence for the expression of cyclooxygenase-2 enzyme in periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12296588&form=6&db=m Effect of selective cyclooxygenase-2 inhibition on the development of ligature-induced periodontitis in rats. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12892443&form=6&db=m The overexpression of cyclo-oxygenase-2 in chronic periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14974816&form=6&db=m Cyclooxygenase-2 inhibitors decrease interleukin-1beta-stimulated prostaglandin E2 and IL-6 production by human gingival fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15668333&form=6&db=m Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15732862&form=6&db=m Impact of an anti-inflammatory therapy and its withdrawal on the progression of experimental periodontitis in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15830643&form=6&db=m Individual and combined effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on endotoxin-induced periodontitis in rats. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15853965&form=6&db=m Protective effects of etoricoxib, a selective inhibitor of cyclooxygenase-2, in experimental periodontitis in rats. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16018763&form=6&db=m Interleukin-1beta-induced prostaglandin E2 production by human gingival fibroblasts is upregulated by glycine. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16229354&form=6&db=m Selective cyclooxygenase-2 inhibition prevents bone resorption. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16584347&form=6&db=m Effects of Selective Cyclooxygenase-2 Inhibitor and Omega-3 Fatty Acid on Serum Interleukin-1beta, Osteocalcin, and C-Reactive Protein Levels in Rats. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17225004&form=6&db=m Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17694359&form=6&db=m Prostaglandin H synthase isoenzyme distribution in the gingival tissue of patients with periodontitis: Pronounced expression adjacent to gram-positive bacteria. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173398&form=6&db=m Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18230102&form=6&db=m Protective effects of baicalin on ligature-induced periodontitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,2,1
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18431039&form=6&db=m Pharmacological topics of bone metabolism: a novel bisphosphonate for the treatment of periodontitis. therapeutic application,unassigned 1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18533784&form=6&db=m COX-2 inhibition decreases VEGF expression and alveolar bone loss during the progression of experimental periodontitis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18834249&form=6&db=m The Effects of Selective COX-2 Inhibitor/Celecoxib and Omega-3 Fatty Acid on Matrix Metalloproteinases, TIMP-1, and Laminin-5gamma2-Chain Immunolocalization in Experimental Periodontitis. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19180322&form=6&db=m Short-term effect of COX-2 selective inhibitor as an adjunct for the treatment of periodontal disease: a clinical double-blind study in humans. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19583750&form=6&db=m Reduction of orthodontic tooth movement by experimentally induced periodontal inflammation in mice. causal interaction,unassigned 1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20177132&form=6&db=m COX-2 is associated with periodontitis in Europeans. causal interaction,unassigned 3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960064&form=6&db=m Treatment of experimental periodontal disease by a selective inhibitor of cyclooxygenase-2 with scaling and root planing (SRP). causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21047437&form=6&db=m Epigenetic change in E-Cardherin and COX-2 to predict chronic periodontitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21481333&form=6&db=m Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21741619&form=6&db=m Enhancement of carbachol-induced amylase secretion in parotid glands from rats with experimental periodontitis. unassigned -
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21939752&form=6&db=m Porphyromonas gingivalis induces RANKL in bone marrow stromal cells: involvement of the p38 MAPK. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22513211&form=6&db=m Influence of experimental periodontitis on cholinergic stimulation of K+ release in rat parotid glands. therapeutic application,unassigned 4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22819245&form=6&db=m Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23185695&form=6&db=m Cyclooxygenase 2 gene polymorphisms and chronic periodontitis in a North Indian population: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23494805&form=6&db=m Curcumin attenuates cyclooxygenase-2 expression via inhibition of the NF-?B pathway in lipopolysaccharide-stimulated human gingival fibroblasts. unassigned -
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23586845&form=6&db=m Periodontitis increases vascular cyclooxygenase-2: potential effect on vascular tone. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23775504&form=6&db=m Olmesartan decreases IL-1? and TNF-? levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23843954&form=6&db=m Carvedilol decrease IL-1? and TNF-?, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis. ongoing research,unassigned 2,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24118063&form=6&db=m Effect of telmisartan on levels of IL-1, TNF-?, down-regulated COX-2, MMP-2, MMP-9 and RANKL/RANK in an experimental periodontitis model. ongoing research,unassigned 3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24267395&form=6&db=m COX-2 gene polymorphisms and risk of chronic periodontitis: a case-control study and meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24528298&form=6&db=m Moving into a new era of periodontal genetic studies: relevance of large case-control samples using severe phenotypes for genome-wide association studies. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24695999&form=6&db=m Association between cyclooxygenase-2 gene polymorphisms and risk of periodontitis: a meta-analysis involving 5653 individuals. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24744546&form=6&db=m Comparative evaluation of the efficacy of the cyclooxygenase pathway inhibitor and nitric oxide synthase inhibitor in the reduction of alveolar bone loss in ligature induced periodontitis in rats: An experimental study. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819928&form=6&db=m Azilsartan increases levels of IL-10, down-regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and up-regulates OPG in an experimental periodontitis model. ongoing research,unassigned 4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26334995&form=6&db=m Genes related to inflammation and bone loss process in periodontitis suggested by bioinformatics methods. causal interaction,unassigned 2,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26430761&form=6&db=m Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26691575&form=6&db=m Endothelial dysfunction in rats with ligature-induced periodontitis: Participation of nitric oxide and cycloxygenase-2-derived products. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26743292&form=6&db=m Cyclooxygenase-2 and matrix metalloproteinase-9 expressions correlate with tissue inflammation degree in periodontal disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28529526&form=6&db=m Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29193331&form=6&db=m Host modulation therapy with anti-inflammatory agents. therapeutic application,unassigned 4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29287688&form=6&db=m Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats. causal interaction,unassigned 3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29335154&form=6&db=m Local administration of Tiludronic Acid downregulates important mediators involved in periodontal tissue destruction in experimental periodontitis in rats. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29539078&form=6&db=m Cyclooxygenase-2 Inhibitors Decrease Interleukin-1?-Stimulated Prostaglandin E causal interaction,unassigned 4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29539151&form=6&db=m Effects of Selective Cyclooxygenase-2 Inhibitor and Omega-3 Fatty Acid on Serum Interleukin-1?, Osteocalcin, and C-Reactive Protein Levels in Rats. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29571257&form=6&db=m Tocoyena sellowiana extract decreases bone loss in an experimental model of periodontitis in rats: Putative role for cyclooxygenase-2 and IL-1? inhibition. ongoing research,unassigned 3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450635&form=6&db=m Assessment of microRNA-144-5p and its putative targets in inflamed gingiva from chronic periodontitis patients. causal interaction,unassigned 1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30970055&form=6&db=m Effects of Selective Versus Non-Selective COX-2 Inhibition on Experimental Periodontitis. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31746655&form=6&db=m Histological evaluation of peri-implant mucosal and gingival tissues in peri-implantitis, peri-implant mucositis and periodontitis patients: a cross-sectional clinical study. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31788052&form=6&db=m Celecoxib suppresses lipopolysaccharide-stimulated oral squamous cell carcinoma proliferation in vitro and in vivo. causal interaction,unassigned 3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31853997&form=6&db=m Long non-coding RNA and mRNA expression profiles in peri-implantitis vs periodontitis. diagnostic usage,unassigned 3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31929206&form=6&db=m PPAR-?, RXR, VDR, and COX-2 Expressions in gingival tissue samples of healthy individuals, periodontitis and peri-implantitis patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32335913&form=6&db=m Cinnamic acid decreases periodontal inflammation and alveolar bone loss in experimental periodontitis. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32426538&form=6&db=m Sex-specific up-regulation of p50-associated COX-2 extragenic RNA (PACER) lncRNA in periodontitis. ongoing research,unassigned 3,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32640491&form=6&db=m Effect of environmental tobacco smoke on COX-2 and SHP-2 expression in a periodontitis rat model. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32867386&form=6&db=m The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33256844&form=6&db=m Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33459718&form=6&db=m Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer's Disease. ongoing research,unassigned 1,0
1.14.99.1 Periodontitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34213019&form=6&db=m Autophagy upregulates inflammatory cytokines in gingival tissue of patients with periodontitis and lipopolysaccharide-stimulated human gingival fibroblasts. diagnostic usage,unassigned 1,0
1.14.99.1 Peripheral Arterial Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19706240&form=6&db=m Selective cyclooxygenase-2 inhibition reduces endothelial dysfunction and improves inflammatory status in patients with intermittent claudication. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Peripheral Arterial Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24775226&form=6&db=m Selective cyclooxygenase-2 inhibition reduces endothelial dysfunction and improves inflammatory status in patients with intermittent claudication. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Peripheral Arterial Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26055794&form=6&db=m Inhibition of cyclooxygenase attenuates the blood pressure response to plantar flexion exercise in peripheral arterial disease. therapeutic application,unassigned 3,0
1.14.99.1 Peripheral Arterial Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912780&form=6&db=m Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Peripheral Arterial Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30039419&form=6&db=m Designing Natural Product Hybrids Bearing Triple Antiplatelet Profile and Evaluating Their Human Plasma Stability. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9376536&form=6&db=m Increased levels of cyclooxygenase-2 mRNA in the rat spinal cord after peripheral inflammation: an in situ hybridization study. diagnostic usage,unassigned 3,0
1.14.99.1 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020867&form=6&db=m Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14568029&form=6&db=m Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14576556&form=6&db=m Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15363658&form=6&db=m Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501312&form=6&db=m Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17055166&form=6&db=m GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19346674&form=6&db=m Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Peripheral Nerve Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23505121&form=6&db=m COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17720896&form=6&db=m Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes. ongoing research,unassigned 4,0
1.14.99.1 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220714&form=6&db=m Cyclooxygenase-2 pathway as a potential therapeutic target in diabetic peripheral neuropathy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Peripheral Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460833&form=6&db=m Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Peripheral Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3149431&form=6&db=m [Defects in the prostaglandin system. VII. (Generalized, inherited [?]) cyclooxygenase defect] causal interaction,unassigned 4,0
1.14.99.1 Peripheral Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6436832&form=6&db=m Plasma factor and platelet sensitivity to prostacyclin in patients with peripheral vascular disease before and after treatment with a combination of a cyclooxygenase and a phosphodiesterase inhibitor. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Peripheral Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18221099&form=6&db=m The role of angiotensin type 1 receptor in inflammation and endothelial dysfunction. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Peritoneal Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17196403&form=6&db=m A selective cyclooxygenase-2 inhibitor decreases transforming growth factor-beta1 synthesis and matrix production in human peritoneal mesothelial cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Peritoneal Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25531215&form=6&db=m Stimulation of Cyclooxygenase 2 Expression in Rat Peritoneal Mesothelial Cells. ongoing research,unassigned 3,0
1.14.99.1 Peritoneal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15868166&form=6&db=m Combination therapy using the cyclooxygenase-2 inhibitor Parecoxib and radioimmunotherapy in nude mice with small peritoneal metastases of colonic origin. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3016060&form=6&db=m Role of thromboxane, prostaglandins and leukotrienes in endotoxic and septic shock. causal interaction,unassigned 4,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6339712&form=6&db=m Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7636393&form=6&db=m Effects of intraperitoneal cyclooxygenase inhibition on inflammatory mediators in dialysate and peritoneal membrane characteristics during peritonitis in continuous ambulatory peritoneal dialysis. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8534265&form=6&db=m Meloxicam: influence on arachidonic acid metabolism. Part II. In vivo findings. ongoing research,unassigned 3,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9808710&form=6&db=m Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA. causal interaction,unassigned 4,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9879550&form=6&db=m Free-radical and cyclooxygenase-catalyzed lipid peroxidation in membranes of blood cells under UV irradiation. therapeutic application,unassigned 1,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807404&form=6&db=m Induction of cyclooxygenase-2 in mesothelial cells in peritonitis caused by perforated ulcers--an immunohistochemical study in humans. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11135056&form=6&db=m Effect of indomethacin on peritoneal protein loss in a rabbit model of peritonitis. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11504678&form=6&db=m Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11989789&form=6&db=m Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. unassigned -
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17110378&form=6&db=m Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. unassigned -
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17618883&form=6&db=m Alterations in spontaneous contractions of rat proximal and distal colon after peritonitis. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17974958&form=6&db=m Inhibition of Cyclooxygenase-2 Suppresses Lymph Node Metastasis via Reduction of Lymphangiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18029280&form=6&db=m Alterations in spontaneous contractions of rat ileum and jejunum after peritonitis. unassigned -
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19222906&form=6&db=m Preclinical pharmacokinetic and pharmacodynamic evaluation of thiazolidinone PG15: an anti-inflammatory candidate. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24126890&form=6&db=m Low doses of celecoxib attenuate gut barrier failure during experimental peritonitis. ongoing research,unassigned 4,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26297443&form=6&db=m Anti-inflammatory and antinociceptive effects of racemic goniothalamin, a styryl lactone. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28017830&form=6&db=m Dermal Fibroblasts Promote Alternative Macrophage Activation Improving Impaired Wound Healing. ongoing research,unassigned 3,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28847433&form=6&db=m Lycopene rich extract from red guava (Psidium guajava L.) displays anti-inflammatory and antioxidant profile by reducing suggestive hallmarks of acute inflammatory response in mice. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Peritonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32296091&form=6&db=m Longitudinal Changes of NF-?B Downstream Mediators and Peritoneal Transport Characteristics in Incident Peritoneal Dialysis Patients. diagnostic usage,unassigned 2,0
1.14.99.1 Peroxisomal Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8261630&form=6&db=m Cyclooxygenase pathway in dermal fibroblasts from patients with metabolic disorders of peroxisomal origin. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Persistent Fetal Circulation Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6854091&form=6&db=m [The effect of indomethacin on placental permeability and the fetal lung circulation] causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20144201&form=6&db=m Chronic infection during placental malaria is associated with up-regulation of cycloxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20880066&form=6&db=m Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2
1.14.99.1 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26632509&form=6&db=m Role of cytosolic and calcium independent phospholipases A2 in insulin secretion impairment of INS-1E cells infected by S. aureus. causal interaction,unassigned 4,0
1.14.99.1 Peutz-Jeghers Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12218179&form=6&db=m Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. ongoing research,unassigned 4,0
1.14.99.1 Peutz-Jeghers Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12650805&form=6&db=m Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome. diagnostic usage,unassigned 3,0
1.14.99.1 Peutz-Jeghers Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623934&form=6&db=m Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Peutz-Jeghers Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15480979&form=6&db=m Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Peutz-Jeghers Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23722652&form=6&db=m N-methylnitrosourea aggravates gastrointestinal polyposis in Lkb1+/- mice. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Pharyngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12025527&form=6&db=m Efficacy of celecoxib in treating symptoms of viral pharyngitis: a double-blind, randomized study of celecoxib versus diclofenac. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Pharyngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15667596&form=6&db=m Effect of sodium azulene sulfonate on capsaicin-induced pharyngitis in rats. unassigned -
1.14.99.1 Pharyngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17525166&form=6&db=m Utility and sensitivity of the sore throat pain model: results of a randomized controlled trial on the COX-2 selective inhibitor valdecoxib. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Pharyngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22814005&form=6&db=m Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Pharyngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32928206&form=6&db=m Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-?B and COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,2,0
1.14.99.1 Pharyngitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777165&form=6&db=m The Acidic Fraction of Isatidis Radix Regulates Inflammatory Response in LPS-Stimulated RAW264.7 Macrophages through MAPKs and NF-?B Pathway. therapeutic application,unassigned 1,0
1.14.99.1 Phenylketonurias http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31690011&form=6&db=m Coupled Genome-Wide DNA Methylation and Transcription Analysis Identified Rich Biomarkers and Drug Targets in Triple-Negative Breast Cancer. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766843&form=6&db=m Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor-differentiated PC12 cells. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11701743&form=6&db=m Increased expression of cyclooxygenase-2 in malignant pheochromocytomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15183459&form=6&db=m Benzo[a]pyrene diol epoxide up-regulates COX-2 expression through NF-kappaB in rat astrocytes. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15917189&form=6&db=m Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway. unassigned -
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16140209&form=6&db=m Nitric oxide induces apoptosis via AP-1-driven upregulation of COX-2 in rat pheochromocytoma cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19227276&form=6&db=m [Role of immunohistochemical study of extracellular matrix components in the estimation of the malignant potential of adrenal pheochromocytomas] causal interaction,unassigned 4,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19497718&form=6&db=m Gi-coupled prostanoid receptors are the likely targets for COX-1-generated prostanoids in rat pheochromocytoma (PC12) cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960108&form=6&db=m Heparanase-1 and Cyclooxygenase-2: prognostic indicators of malignancy in pheochromocytomas. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21350102&form=6&db=m Expression of galectin-3, nm-23, and cyclooxygenase-2 could potentially discriminate between benign and malignant pheochromocytoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21419457&form=6&db=m Predictive Factors for Malignant Pheochromocytoma: Analysis of 136 Patients. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22138303&form=6&db=m Apo J/clusterin expression and secretion: Evidence for 15-deoxy-?(12,14)-PGJ(2)-dependent mechanism. ongoing research,unassigned 4,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23132402&form=6&db=m Simultaneous inhibition of COX-2 and activation of PPAR-? resulted in the same level and pattern of neuroprotection as they were targeted separately. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27357268&form=6&db=m HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31142060&form=6&db=m Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16230411&form=6&db=m Celecoxib and NS-398 enhance photodynamic therapy by increasing in vitro apoptosis and decreasing in vivo inflammatory and angiogenic factors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Photosensitivity Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30741582&form=6&db=m Protective effect of a topical sunscreen formulation fortified with melatonin against UV-induced photodermatitis: an immunomodulatory effect via NF-?B suppression. unassigned -
1.14.99.1 Pigmentation Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32962162&form=6&db=m Antioxidant, Antimicrobial, and Bioactive Potential of Two New Haloarchaeal Strains Isolated from Odiel Salterns (Southwest Spain). causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Pituitary ACTH Hypersecretion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171274&form=6&db=m Cyclooxygenase enzyme and PGE2 expression in patients with functional and non-functional pituitary adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767095&form=6&db=m Cyclooxygenase-2 expression in human pituitary tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902861&form=6&db=m Cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) expression in human pituitary macroadenomas. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15067173&form=6&db=m Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21107210&form=6&db=m Biomarkers of pituitary neoplasms: a review (Part II). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,1
1.14.99.1 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22460097&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in pituitary tumours. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22580984&form=6&db=m Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171274&form=6&db=m Cyclooxygenase enzyme and PGE2 expression in patients with functional and non-functional pituitary adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Pituitary Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32920160&form=6&db=m Analysis of COX-2, PD-L1 and ARG1 expression in human pituitary adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Placenta, Retained http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050071&form=6&db=m Outcomes from Experimental Testing of Nonsteroidal Anti-Inflammatory Drug (NSAID) Administration during the Transition Period of Dairy Cows. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Plasmacytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30820968&form=6&db=m PVT1 (rs13281615) and miR-146a (rs2910164) polymorphisms affect the prognosis of colon cancer by regulating COX2 expression and cell apoptosis. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Platelet Storage Pool Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14602548&form=6&db=m Platelet function tests using platelet aggregometry: need for repetition of the test for diagnosis of defective platelet function. diagnostic usage,unassigned 3,0
1.14.99.1 Pleural Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6416667&form=6&db=m Quantitation of arachidonic acid lipoxygenase products in malignant and nonmalignant effusions. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Pleural Effusion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489511&form=6&db=m Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance). causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,3
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1909963&form=6&db=m Effects of TZI-41127, a novel selective 5-lipoxygenase inhibitor, on A23187-induced pleurisy in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2128168&form=6&db=m Anti-inflammatory pharmacology and mechanism of the orally active capsaicin analogs, NE-19550 and NE-28345. diagnostic usage,unassigned 3,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2771857&form=6&db=m Pharmacological studies on zymosan inflammation in rats and mice. 2: Zymosan-induced pleurisy in rats. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2825482&form=6&db=m Leukotriene B4 production and pharmacologic regulation of reverse passive Arthus pleurisy: importance of antigen dose. unassigned -
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3407548&form=6&db=m Local anti-inflammatory activities of tixocortol 21-pivalate, inhibition of prostaglandins and leukotrienes synthesis, in carrageenin-induced pleurisy. Reversion of effects by RU 486. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7532080&form=6&db=m Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7732867&form=6&db=m Induction of prostaglandin H synthase-2 in rat carrageenin-induced pleurisy and effect of a selective COX-2 inhibitor. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8841835&form=6&db=m Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: roles of complement, bradykinin, and inducible cyclooxygenase-2. unassigned -
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8845830&form=6&db=m Involvement of leukotriene B4 in zymosan-induced rat pleurisy: inhibition of leukocyte infiltration by the 5-lipoxygenase inhibitor T-0757. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8900441&form=6&db=m Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9014217&form=6&db=m Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats. ongoing research,unassigned 3,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9253772&form=6&db=m [Multiple roles of inducible cyclooxygenase-2 and its selective inhibitors] therapeutic application,unassigned 1,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9309800&form=6&db=m Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9760036&form=6&db=m Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10503963&form=6&db=m Expression and function of cyclooxygenase-2 in mesothelial cells during late phase of rat carrageenin-induced pleurisy. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10913594&form=6&db=m Are the anti-inflammatory effects of dexamethasone responsible for inhibition of the induction of enzymes involved in prostanoid formation in rat carrageenin-induced pleurisy? diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093076&form=6&db=m Meloxicam inhibits prostaglandin E(2) generation via cyclooxygenase 2 in the inflammatory site but not that via cyclooxygenase 1 in the stomach. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192935&form=6&db=m Paracetamol-inhibitable COX-2. causal interaction,unassigned 1,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12558194&form=6&db=m Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14673141&form=6&db=m Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14744621&form=6&db=m Effect of methylguanidine in carrageenan-induced acute inflammation in the rats. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15740981&form=6&db=m Local and systemic expression of inducible nitric oxide synthase in comparison with that of cyclooxygenase-2 in rat carrageenin-induced pleurisy. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16259714&form=6&db=m Prostaglandin F(2alpha) produced by inducible cyclooxygenase may contribute to the resolution of inflammation. causal interaction,unassigned 1,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16481007&form=6&db=m Effect of combination of nitric oxide synthase and cyclooxygenase inhibitors on carrageenan-induced pleurisy in rats. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17258197&form=6&db=m Interaction between cyclooxygenase (COX)-1- and COX-2-products modulates COX-2 expression in the late phase of acute inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,2,2
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19791801&form=6&db=m Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors. unassigned -
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20645176&form=6&db=m Cyclooxygenase enzymes and their products in the carrageenan-induced pleurisy in rats. causal interaction,ongoing research,therapeutic application,unassigned 1,2,3,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23587942&form=6&db=m COX-2 expression in stromal fibroblasts self-limits their numbers in lymph node inflammatory responses. ongoing research,unassigned 2,0
1.14.99.1 Pleurisy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24306215&form=6&db=m Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Pleuropneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12443735&form=6&db=m Immunohistochemical detection of cyclooxygenase-2 in lungs of pigs naturally infected with Actinobacillus pleuropneumoniae. therapeutic application,unassigned 1,0
1.14.99.1 Pleuropneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12627710&form=6&db=m Expression of cyclooxygenase-2 in swine naturally infected with Actinobacillus pleuropneumoniae. ongoing research,unassigned 1,0
1.14.99.1 Pleuropneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14672430&form=6&db=m In vitro effects of Actinobacillus pleuropneumoniae on inducible nitric oxide synthase and cyclooxygenase-2 in porcine alveolar macrophages. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Pleuropneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22341869&form=6&db=m 5-Lipoxygenase and cyclooxygenase-2 in the lungs of pigs naturally affected by enzootic pneumonia and porcine pleuropneumonia. causal interaction,unassigned 4,0
1.14.99.1 Pneumococcal Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22441740&form=6&db=m Streptococcus pneumoniae induced regulation of cyclooxygenase-2 in human lung tissue. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pneumoconiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22029678&form=6&db=m Rare pneumoconiosis induced by long-term amorphous silica exposure: the histological characteristics and expression of cyclooxygenase-2 as an antifibrogenic mediator in macrophages. causal interaction,unassigned 1,0
1.14.99.1 Pneumoconiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24899082&form=6&db=m Polymorphisms in cyclooxygenase-2 gene and risk of developing coal workers' pneumoconiosis: a case-control study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2292356&form=6&db=m Protection by indomethacin against acute radiation esophagitis. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2492933&form=6&db=m Lectin-detectable effects of localized pneumonia on airway mucous cell populations: role of cyclooxygenase metabolites. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2714157&form=6&db=m Pulmonary oxygen toxicity in the guinea pig. Effect of indomethacin. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3320011&form=6&db=m Effect of cyclooxygenase blockade on gas exchange and hemodynamics in Pseudomonas pneumonia. therapeutic application,unassigned 1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4053294&form=6&db=m Effect of methylprednisolone and of ibuprofen, a nonsteroidal antiinflammatory agent, on bronchoalveolar inflammation following endotoxemia. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9533935&form=6&db=m Cyclooxygenase isoenzyme localization and mRNA expression in rat lungs. causal interaction,unassigned 3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10471009&form=6&db=m Pulmonary artery contractility in pneumonia: role of cyclooxygenase products and nitric oxide. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10491407&form=6&db=m Allergic lung responses are increased in prostaglandin H synthase-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11055886&form=6&db=m Cyclooxygenase-2 expression in inflammatory lung lesions of nonhuman primates. ongoing research,unassigned 3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11303033&form=6&db=m Cytochrome P450 metabolites of arachidonic acid but not cyclooxygenase-2 metabolites contribute to the pulmonary vascular hyporeactivity in rats with acute Pseudomonas pneumonia. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,1
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11504678&form=6&db=m Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421986&form=6&db=m A key role for prostaglandin I2 in limiting lung mucosal Th2, but not Th1, responses to inhaled allergen. therapeutic application,unassigned 3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12621123&form=6&db=m Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15234907&form=6&db=m Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16492981&form=6&db=m Inhibition of COX-2 Aggravates Neutrophil Migration and Pneumocyte Apoptosis in Surfactant-Depleted Rat Lungs. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16982919&form=6&db=m Cyclooxygenase-1 overexpression decreases Basal airway responsiveness but not allergic inflammation. ongoing research,unassigned 4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17085321&form=6&db=m Concomitant activation of extracellular signal-regulated kinase and induction of COX-2 stimulates maximum prostaglandin E2 synthesis in human airway epithelial cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17330822&form=6&db=m Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17672868&form=6&db=m Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18187276&form=6&db=m COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18237405&form=6&db=m Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18345025&form=6&db=m Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18791491&form=6&db=m HIGH-TIDAL VOLUME VENTILATION AGGRAVATES SEPSIS-INDUCED MULTIORGAN DYSFUNCTION IN A DEXAMETHASONE-INHIBITABLE MANNER. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19051345&form=6&db=m Eriobotrya japonica leaf and its triterpenes inhibited lipopolysaccharide-induced cytokines and inducible enzyme production via the nuclear factor-kappaB signaling pathway in lung epithelial cells. causal interaction,unassigned 3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19084589&form=6&db=m Induction of COX-2 in human airway cells by manganese: role of PI3K/PKB, p38 MAPK, PKCs, Src, and glutathione depletion. causal interaction,unassigned 4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19097981&form=6&db=m Persistent Inactivation of Macrophage Cyclooxygenase-2 in Mycobacterial Pulmonary Inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19373130&form=6&db=m SIGNALING PATHWAYS AND MEDIATORS IN LPS-INDUCED LUNG INFLAMMATION IN DIABETIC RATS: ROLE OF INSULIN. unassigned -
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19717552&form=6&db=m Cigarette smoke extract-induced COX-2 expression via a PKC{alpha}/c-Src/EGFR, PDGFR/PI3K/Akt/NF-{kappa}B pathway and p300 in tracheal smooth muscle cells. causal interaction,unassigned 4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20422273&form=6&db=m Cycloxygenase Inhibition Enhances the Effects of Surfactant Therapy in Endotoxin-Induced Rat Model of ARDS. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21474648&form=6&db=m Cyclooxygenase-2 (COX-2) Regulates Th17 Cell Differentiation During Allergic Lung Inflammation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21669192&form=6&db=m Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21983654&form=6&db=m Formaldehyde induces lung inflammation by an oxidant and antioxidant enzymes mediated mechanism in the lung tissue. ongoing research,unassigned 3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22287609&form=6&db=m Prostaglandins mediate the fetal pulmonary response to intrauterine inflammation. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22341869&form=6&db=m 5-Lipoxygenase and cyclooxygenase-2 in the lungs of pigs naturally affected by enzootic pneumonia and porcine pleuropneumonia. causal interaction,unassigned 4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22441740&form=6&db=m Streptococcus pneumoniae induced regulation of cyclooxygenase-2 in human lung tissue. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22556158&form=6&db=m The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22672748&form=6&db=m Mitigation and Treatment of Radiation-Induced Thoracic Injury With a Cyclooxygenase-2 Inhibitor, Celecoxib. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22696146&form=6&db=m Role of PPAR? in COX-2 Activation in Mycobacterial Pulmonary Inflammation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23326583&form=6&db=m ATP mediates NADPH oxidase/ROS generation and COX-2/PGE2 expression in A549 cells: role of P2 receptor-dependent STAT3 activation. causal interaction,unassigned 4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23449692&form=6&db=m COX-2 Inhibits Th9 Differentiation During Allergic Lung Inflammation Via Downregulation of IL-17RB. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23680674&form=6&db=m Lung inflammation caused by adenosine-5'-triphosphate is mediated via Ca2+/PKCs-dependent COX-2/PGE2 induction. causal interaction,unassigned 4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23690670&form=6&db=m Inflammatory signalings involved in airway and pulmonary diseases. causal interaction,unassigned 1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24925603&form=6&db=m Cyclooxygenase-2 expression in pigs infected experimentally with Mycoplasma hyopneumoniae. ongoing research,unassigned 4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25232731&form=6&db=m Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25670667&form=6&db=m Immunohistochemical Labelling of Cyclooxygenase-2 in Lung Lesions of Calves Infected with Mycoplasma bovis. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25879802&form=6&db=m Inhalation therapy with the synthetic TIP-like peptide AP318 attenuates pulmonary inflammation in a porcine sepsis model. unassigned -
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26396235&form=6&db=m Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27288489&form=6&db=m AdipoR-increased intracellular ROS promotes cPLA2 and COX-2 expressions via activation of PKC and p300 in adiponectin-stimulated human alveolar type II cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28028757&form=6&db=m Dimethyl Sulfoxide Attenuates Acute Lung Injury Induced by Hemorrhagic Shock/Resuscitation in Rats. causal interaction,unassigned 4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28794232&form=6&db=m Resolvin D1 Improves the Resolution of Inflammation via Activating NF-?B p50/p50-Mediated Cyclooxygenase-2 Expression in Acute Respiratory Distress Syndrome. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29967100&form=6&db=m miR-155 Modulates Cockroach Allergen- and Oxidative Stress-Induced Cyclooxygenase-2 in Asthma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30529453&form=6&db=m Temporal profile of serum mitochondrial DNA (mtDNA) in patients with aneurysmal subarachnoid hemorrhage (aSAH). therapeutic application,unassigned 1,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30832310&form=6&db=m Participation of NADPH Oxidase-Related Reactive Oxygen Species in Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2? and COX-2 Expression. unassigned -
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30905077&form=6&db=m Modulative effect of a new hydrazide derivative on wheat-induced pulmonary inflammation in rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31985381&form=6&db=m Fractions of Boswellia serrata suppress LTA4, LTC4, Cyclooxygenase-2 activities and mRNA in HL-60 Cells and reduce lung inflammation in BALB/c mice. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32596244&form=6&db=m The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia. ongoing research,unassigned 4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32995789&form=6&db=m Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907758&form=6&db=m Cyclooxygenase inhibitor use is associated with increased COVID-19 severity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34322123&form=6&db=m Myeloid-Derived Suppressor Cells Dampen Airway Inflammation Through Prostaglandin E2 Receptor 4. unassigned -
1.14.99.1 Pneumonia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34537372&form=6&db=m Airway hyperresponsiveness induced by intermittent hypoxia in rats. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Pneumonia, Pneumococcal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16414978&form=6&db=m Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Pneumoperitoneum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27846663&form=6&db=m Spontaneous Intestinal Perforation: The Long-Term Outcome. diagnostic usage,unassigned 1,0
1.14.99.1 Pneumothorax http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15127973&form=6&db=m Cyclooxygenase-2 is up-regulated in lung parenchyma of chronic obstructive pulmonary disease and down-regulated in idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17537981&form=6&db=m Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24170691&form=6&db=m Renal cyclooxygenase and lipoxygenase products are altered in polycystic kidneys and by dietary soy protein and fish oil treatment in the Han:SPRD-Cy rat. unassigned -
1.14.99.1 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25447343&form=6&db=m Cyclooxygenase product inhibition with acetylsalicylic acid slows disease progression in the Han:SPRD-Cy rat model of polycystic kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1
1.14.99.1 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912780&form=6&db=m Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662341&form=6&db=m Nonselective Cyclooxygenase Inhibition Retards Cyst Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Polycystic Kidney Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671914&form=6&db=m Cyclooxygenase 2 inhibition slows disease progression and improves the altered renal lipid mediator profile in the Pkd2WS25/- mouse model of autosomal dominant polycystic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22415852&form=6&db=m Celecoxib inhibits growth of human autosomal dominant polycystic kidney cyst-lining epithelial cells through the VEGF/Raf/MAPK/ERK signaling pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30662341&form=6&db=m Nonselective Cyclooxygenase Inhibition Retards Cyst Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Polycystic Kidney, Autosomal Dominant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30671914&form=6&db=m Cyclooxygenase 2 inhibition slows disease progression and improves the altered renal lipid mediator profile in the Pkd2WS25/- mouse model of autosomal dominant polycystic kidney disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24330637&form=6&db=m Effect of bee venom on IL-6, COX-2 and VEGF levels in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate. ongoing research,unassigned 2,0
1.14.99.1 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28093231&form=6&db=m The effects of 6-Gingerol on reproductive improvement, liver functioning and Cyclooxygenase-2 gene expression in estradiol valerate - Induced polycystic ovary syndrome in Wistar rats. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Polycystic Ovary Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29026721&form=6&db=m Expression of the genes for peroxisome proliferator-activated receptor-?, cyclooxygenase-2, and proinflammatory cytokines in granulosa cells from women with polycystic ovary syndrome. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Polyhydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3113251&form=6&db=m Treatment of polyhydramnios with prostaglandin synthetase inhibitor (indomethacin). causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Polyhydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8735752&form=6&db=m Treatment of symptomatic polyhydramnios with indomethacin. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Polyhydramnios http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11174490&form=6&db=m Enhancement of amniotic cyclooxygenase type 2 activity in women with preterm delivery associated with twins or polyhydramnios. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Polymyositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15301234&form=6&db=m The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Polymyositis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094001&form=6&db=m Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Polyneuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11271370&form=6&db=m Up-regulation of cyclooxygenase-2 in inflammatory demyelinating neuropathy. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Polyneuropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11870698&form=6&db=m New cyclooxygenase-2 inhibitors for treatment of experimental autoimmune neuritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14694045&form=6&db=m Cyclo-oxygenases and prostaglandins in acute inflammatory demyelination of the peripheral nerve. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Polyuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2949606&form=6&db=m Indomethacin in streptozocin-induced nephrogenic diabetes insipidus. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Polyuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15538275&form=6&db=m Cyclooxygenase-2 inhibitor preserves medullary aquaporin-2 expression and prevents polyuria after ureteral obstruction. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Polyuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585669&form=6&db=m Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Polyuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17229676&form=6&db=m COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Polyuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18216147&form=6&db=m Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Polyuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19692487&form=6&db=m Mice Lacking mPGES-1 Are Resistant to Lithium-Induced Polyuria. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Polyuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20147610&form=6&db=m Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Polyuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24744881&form=6&db=m Lithium induces microcysts and polyuria in adolescent rat kidney independent of cyclooxygenase-2. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Porcine Reproductive and Respiratory Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24352469&form=6&db=m Highly pathogenic porcine reproductive and respiratory syndrome virus induces prostaglandin E2 production through cyclooxygenase 1, which is dependent on the ERK1/2-p-C/EBP-? pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,1
1.14.99.1 Porokeratosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16700663&form=6&db=m Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Post-Exercise Hypotension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465887&form=6&db=m Postexercise hypotension is not explained by a prostaglandin-dependent peripheral vasodilation. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Pouchitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11467644&form=6&db=m Increase in cyclooxygenase-2 and nitric oxide-synthase-2 mRNAs in pouchitis without modification of inducible isoenzyme heme-oxygenase-1. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pouchitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17195901&form=6&db=m Vascular endothelial growth factor and cyclooxygenase-2 are overexpressed in ileal pouch-anal anastomosis. causal interaction,unassigned 4,0
1.14.99.1 Pouchitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19832871&form=6&db=m RISK OF CANCER IN PATIENTS WITH CHRONIC POUCHITIS AFTER RESTORATIVE PROCTOCOLECTOMY FOR ULCERATIVE COLITIS. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,1,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3031819&form=6&db=m The role of arachidonic acid metabolites in preeclampsia. unassigned -
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3923569&form=6&db=m Control of prostacyclin synthesis in pregnancy-induced hypertension. unassigned -
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7708816&form=6&db=m Differentiation and growth on a fibrin matrix modulate the cyclooxygenase expression and thromboxane production by cultured human placental trophoblasts. causal interaction,unassigned 4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7832676&form=6&db=m Activities of phospholipase A2, cyclooxygenase, and PGI2 synthase of umbilical venous endothelial cells in preeclamptic women. ongoing research,unassigned 4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7892893&form=6&db=m Plasma from preeclamptic women increases human endothelial cell prostacyclin production without changes in cellular enzyme activity or mass. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8066098&form=6&db=m Cyclooxygenase gene expression in human endometrium and decidua. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8267046&form=6&db=m Deficient glutathione peroxidase activity in preeclampsia is associated with increased placental production of thromboxane and lipid peroxides. causal interaction,unassigned 3,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9240586&form=6&db=m Aspirin induces increased expression of both prostaglandin H synthase-1 and prostaglandin H synthase-2 in cultured human placental trophoblast. therapeutic application,unassigned 2,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9284743&form=6&db=m The expression and activity of prostaglandin H synthase-2 is enhanced in trophoblast from women with preeclampsia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9402302&form=6&db=m Cyclooxygenase-1 and -2 in human placenta and placental bed after normal and pre-eclamptic pregnancies. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10087724&form=6&db=m The expression of cyclooxygenase-2 in human umbilical vein endothelial cell culture from preeclampsia. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10329876&form=6&db=m The effect of indomethacin and prostacyclin agonists on blood pressure in a rat model of preeclampsia. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10561943&form=6&db=m The induction of cyclooxygenase-2 (COX-2) in cultured endothelial cells treated with serum from preeclampsia is mediated by interleukin-6. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11477204&form=6&db=m Thromboxane A(2) limits differentiation and enhances apoptosis of cultured human trophoblasts. causal interaction,unassigned 4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14683695&form=6&db=m Eicosanoids in preeclampsia. unassigned -
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16930602&form=6&db=m Placental tissue cyclo-oxygenase 1 and 2 in pre-eclamptic and normal pregnancy. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17240230&form=6&db=m Activation of NF-kappaB and expression of COX-2 in association with neutrophil infiltration in systemic vascular tissue of women with preeclampsia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369461&form=6&db=m Microparticles from preeclamptic women induce vascular hyporeactivity in vessels from pregnant mice through an overproduction of NO. causal interaction,unassigned 1,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20144201&form=6&db=m Chronic infection during placental malaria is associated with up-regulation of cycloxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20220108&form=6&db=m Neutrophil expression of cyclooxygenase 2 in preeclampsia. unassigned -
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22224631&form=6&db=m -765 G?C and -1195 A?G Promoter Variants of the Cyclooxygenase-2 Gene Decrease the Risk for Preeclampsia. therapeutic application,unassigned 1,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25863097&form=6&db=m [Association study between -765G > C and -1195G > A functional polymorphisms in the cyclooxygenase 2 gene and risk of preeclampsia]. therapeutic application,unassigned 1,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25877604&form=6&db=m [The changes of LCHAD in preeclampsia with different clinical features and the correlation with NADPH P47-phox, p38MAPK-?, COX-2 and serum FFA and TG]. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27465134&form=6&db=m The Study of Cyclooxygenase 2 in Human Decidua of Preeclampsia. ongoing research,unassigned 4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912780&form=6&db=m Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29999276&form=6&db=m Increased Expression of Thioredoxin-1 Binding Protein-2 in Placentas in Preeclampsia. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30055669&form=6&db=m TGF-?1 inhibits human trophoblast cell invasion by upregulating cyclooxygenase-2. causal interaction,unassigned 3,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31420920&form=6&db=m Aspirin for the prevention and treatment of pre-eclampsia: A matter of COX-1 and/or COX-2 inhibition? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32002054&form=6&db=m Curcumin's Effect on COX-2 and IL-10 Serum in Preeclampsia's Patient Undergo Sectio Caesarea with Spinal Anesthesia. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33144212&form=6&db=m Mechanisms of vascular dysfunction in the interleukin-10-deficient murine model of preeclampsia indicate nitric oxide dysregulation. causal interaction,unassigned 3,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33482597&form=6&db=m Maternal vitamin D deficiency influences long-chain polyunsaturated fatty acids and pregnancy outcome in association with alterations in one-carbon metabolism. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34045549&form=6&db=m Vitamin D stimulates miR-26b-5p to inhibit placental COX-2 expression in preeclampsia. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34168274&form=6&db=m The preventive effects of aspirin on preeclampsia based on network pharmacology and bioinformatics. therapeutic application,unassigned 1,0
1.14.99.1 Precancerous Conditions http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943943&form=6&db=m Cyclooxygenase-2 expression in early gastric cancer, intestinal metaplasia and Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20944149&form=6&db=m Association study of cyclooxygenase 2 single nucleotide polymorphisms and childhood acute lymphoblastic leukemia in Taiwan. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28270082&form=6&db=m ?-lactam structured,4-(4-(Methylsulfonyl)phenyl)-1-pentyl-3-phenoxyazetidin-2-one: Selectively targets cancerous B lymphocyte Mitochondria. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502647&form=6&db=m Inhibitory effect of berberine on interleukin-2 secretion from PHA-treated lymphocytic Jurkat cells. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31698450&form=6&db=m Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32772580&form=6&db=m Evaluation of Cytotoxic Potentials of Novel Cyclooxygenase-2 Inhibitor against ALL Lymphocytes and Normal Lymphocytes and Its Anticancer Effect through Mitochondrial Pathway. ongoing research,unassigned 4,0
1.14.99.1 Pregnancy, Prolonged http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16399999&form=6&db=m Effects of progesterone on iNOS, COX-2, and collagen expression in the cervix. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Pregnancy, Prolonged http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18833324&form=6&db=m Loss of cannabinoid receptor CB1 induces preterm birth. unassigned -
1.14.99.1 Pregnancy, Prolonged http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22814005&form=6&db=m Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Pregnancy, Prolonged http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22891569&form=6&db=m [Developmental toxicity of the over-the-counter analgetics and antypiretics]. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10591596&form=6&db=m Progesterone and prostaglandin H synthase-2 involvement in alcohol-induced preterm birth in mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,3
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11395920&form=6&db=m The role of n-3 fatty acids in gestation and parturition. causal interaction,unassigned 3,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12144874&form=6&db=m Efficacy and specificity of non-steroidal anti-inflammatory drugs for the inhibition of cytokine-stimulated prostaglandin E(2) secretion by amnion-derived WISH cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16202923&form=6&db=m The promise of prostaglandins: have they fulfilled their potential as therapeutic targets for the delay of preterm birth? causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16857891&form=6&db=m Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice. therapeutic application,unassigned 1,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17017909&form=6&db=m In utero exposure to phthalates and fetal development. causal interaction,unassigned 3,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22378764&form=6&db=m NODAL in the Uterus Is Necessary for Proper Placental Development and Maintenance of Pregnancy. ongoing research,unassigned 2,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22676250&form=6&db=m N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23184961&form=6&db=m Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24933116&form=6&db=m The effect of progesterone on genes involved in preterm labor. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26036283&form=6&db=m Mono-ethylhexyl phthalate stimulates prostaglandin secretion in human placental macrophages and THP-1 cells. causal interaction,ongoing research,unassigned 2,2,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26037299&form=6&db=m Resveratrol Protects Against Pathological Preterm Birth by Suppression of Macrophage-Mediated Inflammation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26430761&form=6&db=m Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29351170&form=6&db=m Risk of preterm birth following late pregnancy exposure to NSAIDs or COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30006439&form=6&db=m IRF5 is increased in labouring myometrium and regulates pro-labour mediators. unassigned -
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30661374&form=6&db=m Cyclo-oxygenase inhibitors for treating preterm labour: what is the molecular evidence? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32582166&form=6&db=m De novo Synthesis of SAA1 in the Placenta Participates in Parturition. unassigned -
1.14.99.1 Premature Birth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34231170&form=6&db=m The Preventive Effects of Quercetin on Preterm Birth Based on Network Pharmacology and Bioinformatics. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Pressure Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27091651&form=6&db=m Selective inhibition of COX-2 improves cutaneous wound healing of pressure ulcers in mice through reduction of iNOS expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Primary Ovarian Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33632047&form=6&db=m An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects. ongoing research,unassigned 2,0
1.14.99.1 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10652449&form=6&db=m Cyclooxygenase-2 is highly expressed in microglial-like cells in a murine model of prion disease. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11739606&form=6&db=m Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11792368&form=6&db=m Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Prion Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17678966&form=6&db=m Cyclooxygenase-2, prostaglandin E2, and microglial activation in prion diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Prognathism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28570402&form=6&db=m Genetic Factors Involved in Mandibular Prognathism. unassigned -
1.14.99.1 Prolactinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22580984&form=6&db=m Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Prolactinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32171274&form=6&db=m Cyclooxygenase enzyme and PGE2 expression in patients with functional and non-functional pituitary adenomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 prostaglandin-e synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15016822&form=6&db=m Deletion of microsomal prostaglandin E2 (PGE2) synthase-1 reduces inducible and basal PGE2 production and alters the gastric prostanoid profile. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=427045&form=6&db=m Further studies on a specific platelet antibody found in Bernard-Soulier syndrome and its effects on normal platelet function. therapeutic application,unassigned 1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3149431&form=6&db=m [Defects in the prostaglandin system. VII. (Generalized, inherited [?]) cyclooxygenase defect] causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3563982&form=6&db=m DDAVP-induced correction of prolonged bleeding time in patients with congenital platelet function defects. unassigned -
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6429881&form=6&db=m A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7331991&form=6&db=m Epinephrine potentiation of arachidonate-induced aggregation of cyclooxygenase-deficient platelets. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7477380&form=6&db=m Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8562397&form=6&db=m Bleeding disorder due to platelet prostaglandin H synthase-1 (PGHS-1) deficiency. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9346237&form=6&db=m Multiple female reproductive failures in cyclooxygenase 2-deficient mice. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9751758&form=6&db=m Opposing actions of prostaglandins and oxytocin determine the onset of murine labor. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9833516&form=6&db=m [Platelet cyclooxygenase deficiency] causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10969080&form=6&db=m Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11290559&form=6&db=m Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11442478&form=6&db=m Characterization of a partial prostaglandin endoperoxide H synthase-1 deficiency in a patient with a bleeding disorder. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11743745&form=6&db=m A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745453&form=6&db=m Is COX-2 inhibition a panacea for cancer prevention? causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12045254&form=6&db=m Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. unassigned -
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12055598&form=6&db=m COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14518562&form=6&db=m Inducible brain COX-2 facilitates the recurrence of hippocampal seizures in mouse rapid kindling. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14602548&form=6&db=m Platelet function tests using platelet aggregometry: need for repetition of the test for diagnosis of defective platelet function. diagnostic usage,unassigned 3,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14688622&form=6&db=m Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice. ongoing research,unassigned 2,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15451306&form=6&db=m Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice. causal interaction,unassigned 3,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15778012&form=6&db=m Role of cyclooxygenase-2 in deoxynivalenol-induced immunoglobulin a nephropathy. causal interaction,unassigned 2,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15823178&form=6&db=m Augmentation of allergic inflammation in the airways of cyclooxygenase-2-deficient mice. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16184423&form=6&db=m Rebamipide reduces delay in gastric ulcer healing in cyclooxygenase-2-deficient mice. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16272346&form=6&db=m Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16297651&form=6&db=m COX-2 inhibition affects growth rate of Chlamydia muridarum within epithelial cells. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16373427&form=6&db=m Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16380543&form=6&db=m Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16518767&form=6&db=m Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Gastric Inflammation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16566823&form=6&db=m Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16707480&form=6&db=m HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16787416&form=6&db=m Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis. causal interaction,unassigned 2,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16977189&form=6&db=m Cyclooxygenase-2 deficiency protects livers from ischemia/reperfusion injury. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17238138&form=6&db=m Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17496151&form=6&db=m Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17510193&form=6&db=m Inactivation of inducible nitric oxide synthase protects intestinal pacemaker cells from postoperative damage. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17643885&form=6&db=m A novel anti-atherogenic role for COX-2--potential mechanism for the cardiovascular side effects of COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18209082&form=6&db=m Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia/reperfusion injury. causal interaction,unassigned 3,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18438879&form=6&db=m Arthritis develops but fails to resolve during inhibition of cyclooxygenase 2 in a murine model of Lyme disease. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18657183&form=6&db=m Cyclooxygenase-2 deficiency modifies the neurochemical effects, motor impairment and co-morbid anxiety provoked by paraquat administration in mice. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20038958&form=6&db=m Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20471507&form=6&db=m Basal bone phenotype and increased anabolic responses to intermittent parathyroid hormone in healthy male COX-2 knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20657653&form=6&db=m Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20961858&form=6&db=m Cyclooxygenase-2 deficiency attenuates adipose tissue differentiation and inflammation in mice. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21967897&form=6&db=m Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22012553&form=6&db=m The role of the EP receptors for prostaglandin E2 in skin and skin cancer. causal interaction,unassigned 1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22219191&form=6&db=m Induction of COX-2 Enzyme and Down-regulation of COX-1 Expression by Lipopolysaccharide (LPS) Control Prostaglandin E2 Production in Astrocytes. therapeutic application,unassigned 1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22447972&form=6&db=m Concomitant activation of functionally opposing prostacyclin and thromboxane prostanoid receptors by cyclo-oxygenase-1-mediated prostacyclin synthesis in mouse arteries. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22522619&form=6&db=m PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22902545&form=6&db=m Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23127498&form=6&db=m Effect of celecoxib on cyclooxygenase-1-mediated prostacyclin synthesis and endothelium-dependent contraction in mouse arteries. causal interaction,unassigned 1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23733875&form=6&db=m Cyclooxygenase-2 deficiency in macrophages leads to defective p110? PI3K signaling and impairs cell adhesion and migration. unassigned -
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23986518&form=6&db=m A vasoconstrictor role for cyclooxygenase-1-mediated prostacyclin synthesis in mouse renal arteries. ongoing research,unassigned 3,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23987235&form=6&db=m Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24480756&form=6&db=m Late Postoperative Hemorrhage in a Patient With Undiagnosed COX-1 Deficiency After Third Molar Extractions. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24878773&form=6&db=m Vasoconstrictor role of cyclooxygenase-1-mediated prostacyclin synthesis in non-insulin-dependent diabetic mice induced by high-fat diet and streptozotocin. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26272103&form=6&db=m Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice. ongoing research,unassigned 3,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26308616&form=6&db=m Vasomotor Reaction to Cyclooxygenase-1-Mediated Prostacyclin Synthesis in Carotid Arteries from Two-Kidney-One-Clip Hypertensive Mice. unassigned -
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26316178&form=6&db=m Hematopoietic cyclooxygenase-2 deficiency increases adipose tissue inflammation and adiposity in obesity. causal interaction,unassigned 4,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26856544&form=6&db=m Role of COX-2-derived PGE2 on vascular stiffness and function in hypertension. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27354351&form=6&db=m Cyclooxygenase-2 deficiency impairs muscle-derived stem cell-mediated bone regeneration via cellular autonomous and non-autonomous mechanisms. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27425247&form=6&db=m Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29636862&form=6&db=m Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30044110&form=6&db=m Impaired post-irradiation survival of cyclooxygenase-2-deficient mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 prostaglandin-endoperoxide synthase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32659532&form=6&db=m Inflammation with the participation of arachidonic (AA) and linoleic acid (LA) derivatives (HETEs and HODEs) is necessary in the course of a normal reproductive cycle and pregnancy. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11018637&form=6&db=m Expression of cyclooxygenase-1 and cyclooxygenase-2 in the human prostate. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11396201&form=6&db=m Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11769607&form=6&db=m [Expression of COX-2 in prostatic cancer and benign prostatic hyperplasia] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963122&form=6&db=m The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16122891&form=6&db=m Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16597032&form=6&db=m [Expression of cyclooxygenase-2 and vascular endothelial growth factor in human prostate cancer and its significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18242387&form=6&db=m CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556211&form=6&db=m Cyclooxygenase-2 overexpression in chronic inflammation associated with benign prostatic hyperplasia: is it related to apoptosis and angiogenesis of prostate cancer? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23862231&form=6&db=m [Correlation of IPSS with IL-8 and COX-2 levels in patients with benign prostatic hyperplasia and prostatitis]. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24246211&form=6&db=m Adding Cyclooxygenase-2 inhibitor to alpha blocker for patients with benign prostate hyperplasia and elevated serum prostate specific antigen could not improve prostate biopsy detection rate but improve lower urinary tract symptoms. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26125280&form=6&db=m Predictive value of Cyclooxygenase-2 over expression for identifying prostate cancer from benign prostatic hyperplasia in prostate biopsy specimens. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402808&form=6&db=m Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32129166&form=6&db=m Insilico and In Vitro Study: COX-2 Inhibition by Ethanol Extract of Dayak Onion Bulb (Eleutherine americana Merr) as Treatment Innovation of Benign Prostatic Hyperplasia (BPH). therapeutic application,unassigned 3,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32753632&form=6&db=m The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Hyperplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33148606&form=6&db=m The role of macrophage migration inhibitory factor in promoting benign prostatic hyperplasia epithelial cell growth by modulating COX-2 and P53 signaling. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310211&form=6&db=m Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11502467&form=6&db=m The role of cyclooxygenase-2 in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751373&form=6&db=m Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779161&form=6&db=m Prostaglandin E(2) stimulates prostatic intraepithelial neoplasia cell growth through activation of the interleukin-6/GP130/STAT-3 signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17265445&form=6&db=m Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055324&form=6&db=m Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Prostatic Intraepithelial Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468781&form=6&db=m Overexpression of ELAV-like Protein HuR is Associated with Increased COX-2 Expression in Atrophy, High-grade Prostatic Intraepithelial Neoplasia, and Incidental Prostate Cancer in Cystoprostatectomies. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9321948&form=6&db=m Up-regulation of cyclooxygenase-2 by product-prostaglandin E2. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9766645&form=6&db=m NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9933075&form=6&db=m Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis. therapeutic application,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10451445&form=6&db=m Induction of prostaglandin G/H synthase-2 in a canine model of spontaneous prostatic adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10484067&form=6&db=m Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines. causal interaction,unassigned 1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10579801&form=6&db=m Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10753955&form=6&db=m The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10919714&form=6&db=m Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953162&form=6&db=m Inhibition of cyclooxygenase-2 suppresses angiogenesis and the growth of prostate cancer in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10953290&form=6&db=m Immunohistochemical study of cyclooxygenases in prostatic adenocarcinoma; relationship to apoptosis and Bcl-2 protein expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10969817&form=6&db=m Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11069387&form=6&db=m Cytoplasmic induction and over-expression of cyclooxygenase-2 in human prostate cancer: implications for prevention and treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078056&form=6&db=m Biochemistry of cyclooxygenase (COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11289153&form=6&db=m Differential expression of cyclooxygenase-2 and its regulation by tumor necrosis factor-alpha in normal and malignant prostate cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11295599&form=6&db=m Proapoptotic anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11304122&form=6&db=m DNA oxidation induced by cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310211&form=6&db=m Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11384747&form=6&db=m Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11396201&form=6&db=m Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11442675&form=6&db=m Induction of apoptosis by cyclooxygenase-2 inhibitors in prostate cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11489728&form=6&db=m Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11502467&form=6&db=m The role of cyclooxygenase-2 in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11688844&form=6&db=m Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11751373&form=6&db=m Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11769607&form=6&db=m [Expression of COX-2 in prostatic cancer and benign prostatic hyperplasia] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11779161&form=6&db=m Prostaglandin E(2) stimulates prostatic intraepithelial neoplasia cell growth through activation of the interleukin-6/GP130/STAT-3 signaling pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11785654&form=6&db=m Novel antineoplastic isochalcones inhibit the expression of cyclooxygenase 1,2 and EGF in human prostate cancer cell line LNCaP. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11861541&form=6&db=m Molecular characterization of canine prostaglandin G/H synthase-2 and regulation in prostatic adenocarcinoma cells in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11876163&form=6&db=m COX-2 specific inhibitor, NS-398, increases macrophage migration inhibitory factor expression and induces neuroendocrine differentiation in C4-2b prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11913955&form=6&db=m Saw palmetto berry extract inhibits cell growth and Cox-2 expression in prostatic cancer cells. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11935209&form=6&db=m Dihydrotestosterone (DHT) modulates the ability of NSAIDs to induce apoptosis of prostate cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11959891&form=6&db=m Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12085962&form=6&db=m Role of eicosanoids in prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12357301&form=6&db=m Superior effectiveness of ibuprofen compared with other NSAIDs for reducing the survival of human prostate cancer cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12386924&form=6&db=m Cyclooxygenase-2 promotes prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12401798&form=6&db=m Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12431818&form=6&db=m Angiogenesis in prostate cancer: its role in disease progression and possible therapeutic approaches. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12464646&form=6&db=m Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12498388&form=6&db=m Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12618325&form=6&db=m Cyclooxygenase-2 and prostate carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664596&form=6&db=m Determination of cyclooxygenase and arachidonic acid metabolites in invasive human prostate cancer cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12735500&form=6&db=m Chemoprevention of prostate cancer. Focus on key opportunities and clinical trials. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795054&form=6&db=m COX-2 inhibitors and other NSAIDs in bladder and prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12917209&form=6&db=m The cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs celecoxib and nimesulide inhibit androgen receptor activity via induction of c-Jun in prostate cancer cells. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960143&form=6&db=m Suppression of N-methyl-N-nitrosourea/testosterone-induced rat prostate cancer growth by celecoxib: effects on cyclooxygenase-2, cell cycle regulation, and apoptosis mechanism(s). causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14581372&form=6&db=m Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14640786&form=6&db=m Radiation-induced cyclooxygenase 2 up-regulation is dependent on redox status in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14666698&form=6&db=m Effect of cyclooxygenase-2 (COX-2) inhibitors on prostate cancer cell proliferation. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14713745&form=6&db=m Prostate cancer chemoprevention: an overview of United States trials. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14713756&form=6&db=m Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14754878&form=6&db=m COX-2 gene promoter haplotypes and prostate cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14764122&form=6&db=m A pilot study of use of the cyclooxygenase-2 inhibitor celecoxib in recurrent prostate cancer after definitive radiation therapy or radical prostatectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15026333&form=6&db=m Hypermethylation of CpG islands in primary and metastatic human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15066236&form=6&db=m What's New in the Field of Prostate Cancer Chemoprevention? causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15126378&form=6&db=m Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138613&form=6&db=m The effects of cyclooxygenase-2 inhibitors on urological cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179622&form=6&db=m COX-2 inhibitors and other nonsteroidal anti-inflammatory drugs in genitourinary cancer. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240520&form=6&db=m A cox-2 promoter-based replication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15287094&form=6&db=m Chronic inflammation in benign prostate hyperplasia is associated with focal upregulation of cyclooxygenase-2, Bcl-2, and cell proliferation in the glandular epithelium. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15374967&form=6&db=m Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small-cell lung cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15384741&form=6&db=m COX-2 inhibition and cancer: experimental findings and clinical correlates. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15454489&form=6&db=m A novel celecoxib derivative, OSU03012, induces cytotoxicity in primary CLL cells and transformed B-cell lymphoma cell line via a caspase- and Bcl-2-independent mechanism. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15466184&form=6&db=m Oncogenic action of secreted phospholipase A2 in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15533896&form=6&db=m Peroxisome proliferator-activated receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546559&form=6&db=m Synergistic effects of Cox-1 and -2 inhibition on bladder and prostate cancer in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15550400&form=6&db=m Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15566290&form=6&db=m New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy. causal interaction,unassigned 3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15570007&form=6&db=m Regression of mouse prostatic intraepithelial neoplasia by nonsteroidal anti-inflammatory drugs in the transgenic adenocarcinoma mouse prostate model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15579005&form=6&db=m Novel insights and therapeutical applications in the field of inhibitors of COX-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585639&form=6&db=m Inhibition of cyclooxygenase (COX)-2 expression by Tet-inducible COX-2 antisense cDNA in hormone-refractory prostate cancer significantly slows tumor growth and improves efficacy of chemotherapeutic drugs. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15655565&form=6&db=m Expression of biomarkers modulating prostate cancer progression: implications in the treatment of the disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15657282&form=6&db=m Estrogen-dependent induction of cyclooxygenase-2 in the canine prostate in vivo. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15688368&form=6&db=m Cyclooxygenase-2 inhibitor celecoxib augments chemotherapeutic drug-induced apoptosis by enhancing activation of caspase-3 and -9 in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15703837&form=6&db=m A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-kappaB, and steroid hormone receptors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15756026&form=6&db=m Celecoxib inhibits prostate cancer growth: evidence of a cyclooxygenase-2-independent mechanism. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15816526&form=6&db=m The effect of cyclooxygenase-2 (COX-2) inhibition on human prostate cancer induced osteoblastic and osteolytic lesions in bone. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15867220&form=6&db=m Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15869721&form=6&db=m What's new in the field of prostate cancer chemoprevention? causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15878913&form=6&db=m Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15907789&form=6&db=m Resistance of prostate cancer cell lines to COX-2 inhibitor treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15963122&form=6&db=m The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16044418&form=6&db=m Inhibition of the Akt, cyclooxygenase-2, and matrix metalloproteinase-9 pathways in combination with androgen deprivation therapy: potential therapeutic approaches for prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16123581&form=6&db=m Cyclooxygenase-2 and Angiogenesis in Prostate Cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127634&form=6&db=m American Urological Association--94th annual meeting. 1-6 May 1999, Dallas, USA. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139948&form=6&db=m Immunohistochemical expression of Ki-67 antigen, cox-2 and Bax/Bcl-2 in prostate cancer; prognostic value in biopsies and radical prostatectomy specimens. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16182442&form=6&db=m Oncogenic action of phospholipase A2 in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16201851&form=6&db=m Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16218400&form=6&db=m [Relationship between cyclooxygenase (COX)-2 and malignant tumors] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16322342&form=6&db=m Zoledronic acid cooperates with a cyclooxygenase-2 inhibitor and gefitinib in inhibiting breast and prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16360450&form=6&db=m Antitumor effects of etodolac, a selective cyclooxygenase-II inhibitor, against human prostate cancer cell lines in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16425990&form=6&db=m Cyclooxygenase-2: a therapeutic target for prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16443360&form=6&db=m Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16450727&form=6&db=m [Nutrition and pharmacological treatment for prevention of prostate cancer] causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16503858&form=6&db=m Management of prostate cancer. Part 1: chemoprevention. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16506214&form=6&db=m Genetic variation in the COX-2 gene and the association with prostate cancer risk. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16519157&form=6&db=m [Expression and implication of cyclooxygenase-2 mRNA in prostate cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16557596&form=6&db=m Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrence. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16585199&form=6&db=m Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16597032&form=6&db=m [Expression of cyclooxygenase-2 and vascular endothelial growth factor in human prostate cancer and its significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16609031&form=6&db=m Phase II Trial of Celecoxib in Prostate-Specific Antigen Recurrent Prostate Cancer after Definitive Radiation Therapy or Radical Prostatectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16646082&form=6&db=m Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16722607&form=6&db=m Combination of celecoxib with percutaneous radiotherapy in patients with localised prostate cancer - a phase I study. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731743&form=6&db=m RNA interference-mediated cyclooxygenase-2 inhibition prevents prostate cancer cell growth and induces differentiation: modulation of neuronal protein synaptophysin, cyclin D1, and androgen receptor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16782907&form=6&db=m Cyclooxygenase-2 selective inhibitors and prostate cancer: what is the clinical benefit? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16782912&form=6&db=m Celecoxib versus placebo for men with prostate cancer and a rising serum prostate-specific antigen after radical prostatectomy and/or radiation therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16848363&form=6&db=m [Molecular-targeted therapy for hormone-refractory prostate cancer] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16861115&form=6&db=m The epidemiology of prostate cancer--with a focus on nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899616&form=6&db=m Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16985700&form=6&db=m Cyclooxygenase-2 as a marker for prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17066444&form=6&db=m Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17107625&form=6&db=m Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17122632&form=6&db=m An inverse relation between COX-2 and E-cadherin expression correlates with aggressive histologic features in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17207548&form=6&db=m Inhibition of cyclooxygenase-2 activity by celecoxib does not lead to radiosensitization of human prostate cancer cells in vitro. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17265445&form=6&db=m Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17309847&form=6&db=m COX-2 inhibition: a possible role in the management of prostate cancer? causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17332308&form=6&db=m Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17409433&form=6&db=m The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17434257&form=6&db=m Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17462298&form=6&db=m The risks and benefits of cyclo-oxygenase-2 inhibitors in prostate cancer: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17609663&form=6&db=m COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612052&form=6&db=m Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17661725&form=6&db=m A retrospective analysis of cardiovascular morbidity in metastatic hormone-refractory prostate cancer patients on high doses of the selective COX-2 inhibitor celecoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17695530&form=6&db=m Anticancer effects of licofelone (ML-3000) in prostate cancer cells. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17764114&form=6&db=m Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17881290&form=6&db=m COX-2 expression predicts prostate-cancer outcome: analysis of data from the RTOG 92-02 trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17908994&form=6&db=m Exisulind in Combination with Celecoxib Modulates Epidermal Growth Factor Receptor, Cyclooxygenase-2, and Cyclin D1 against Prostate Carcinogenesis: In vivo Evidence. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17911400&form=6&db=m Benign prostatic hyperplasia (BPH) epithelial cell line BPH-1 induces aromatase expression in prostatic stromal cells via prostaglandin E2. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17913653&form=6&db=m Cyclooxygenase-2 inhibitors and prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17942462&form=6&db=m The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17970642&form=6&db=m Non-steroidal anti-inflammatory drugs in the treatment of genitourinary malignancies: focus on clinical data. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17998819&form=6&db=m CD44 and PTGS2 methylation are independent prognostic markers for biochemical recurrence among prostate cancer patients with clinically localized disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17999989&form=6&db=m Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18030357&form=6&db=m Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18055324&form=6&db=m Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18061030&form=6&db=m Inflammation and prostate cancer: a future target for prevention and therapy? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18064740&form=6&db=m CD44 and PTGS2 methylation are independent prognostic markers for biochemical recurrence among prostate cancer patients with clinically localized disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18089846&form=6&db=m The effects of cyclooxygenase-2 expression in prostate cancer cells: modulation of response to cytotoxic agents. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18199714&form=6&db=m Statin induces apoptosis and cell growth arrest in prostate cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202756&form=6&db=m Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18242387&form=6&db=m CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18343442&form=6&db=m The arachidonic Acid pathway and its role in prostate cancer development and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18386814&form=6&db=m A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18468781&form=6&db=m Overexpression of ELAV-like Protein HuR is Associated with Increased COX-2 Expression in Atrophy, High-grade Prostatic Intraepithelial Neoplasia, and Incidental Prostate Cancer in Cystoprostatectomies. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645679&form=6&db=m Cyclooxygenase-2 expression is dependent upon epidermal growth factor receptor expression or activation in androgen independent prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18649743&form=6&db=m [Effects of a selective cyclooxygenase 2 inhibitor celecoxib on the proliferation and apoptosis of human prostate cancer cell line PC-3] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18825552&form=6&db=m Modeling of cyclooxygenase-2 and 5-lipooxygenase inhibitory activity of apoptosis-inducing agents potentially useful in prostate cancer chemotherapy: Derivatives of diarylpyrazole. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18829529&form=6&db=m Prostaglandin E2 regulates tumor angiogenesis in prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18973191&form=6&db=m SmgGDS is up-regulated in prostate carcinoma and promotes tumour phenotypes in prostate cancer cells. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18974063&form=6&db=m COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19102508&form=6&db=m [Cyclooxygenase-2 and cyclooxygenase-2 inhibitors in prostate cancer] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19139136&form=6&db=m NS-398, ibuprofen, and cyclooxygenase-2 RNA interference produce significantly different gene expression profiles in prostate cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19200641&form=6&db=m Pharmacological Approaches to Reducing the Risk of Prostate Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19318492&form=6&db=m Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19402383&form=6&db=m Expression of immunomodulating genes in prostate cancer and benign prostatic tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19443354&form=6&db=m A randomized controlled trial investigating the effects of celecoxib in patients with localized prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19451093&form=6&db=m A gene expression profiling approach assessing celecoxib in a randomized controlled trial in prostate cancer. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568414&form=6&db=m Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19608016&form=6&db=m Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19618291&form=6&db=m Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-kappaB in prostate cancer cells. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19621664&form=6&db=m Expression of c-erbB-2 and cyclooxygenase-2 in intrahepatic cholangiocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19680997&form=6&db=m Pitfalls in the use of arachidonic acid oxidation products to assign lipoxygenase activity in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19707453&form=6&db=m The target of arachidonic acid pathway is a new anticancer strategy for human prostate cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19720908&form=6&db=m Phase II, Randomized, Placebo-Controlled Trial of Neoadjuvant Celecoxib in Men With Clinically Localized Prostate Cancer: Evaluation of Drug-Specific Biomarkers. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19772879&form=6&db=m Multifunctional role of VIP in prostate cancer progression in a xenograft model: Suppression by curcumin and COX-2 inhibitor NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19776642&form=6&db=m omega-3 Fatty Acids, Genetic Variants in COX-2 and Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19836060&form=6&db=m Prognostic relevance of cyclooxygenase-2 (COX-2) expression in Chinese patients with prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19895521&form=6&db=m Prolonging androgen sensitivity in prostate cancer - a role for COX inhibitors? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19918950&form=6&db=m Synthesis and antitumor properties of selenocoxib-1 against rat prostate adenocarcinoma cells. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19965896&form=6&db=m PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3). causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20067451&form=6&db=m Methylated genes as potential biomarkers in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227393&form=6&db=m Prostaglandin E2 modulates components of the Wnt signaling system in bone and prostate cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20227521&form=6&db=m Decrease in expression or activity of cytosolic phospholipase A(2)alpha increases cyclooxygenase-1 action: A cross-talk between key enzymes in arachidonic acid pathway in prostate cancer cells. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20339581&form=6&db=m The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20375691&form=6&db=m TGF-beta1 Reverses Inhibition of COX-2 With NS398 and Increases Invasion in Prostate Cancer Cells. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20409773&form=6&db=m COX-2 is overexpressed in primary prostate cancer with metastatic potential and may predict survival. A comparison study between COX-2, TGF-beta, IL-10 and Ki67. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20431935&form=6&db=m Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20532752&form=6&db=m Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: the roles of NF-kappaB and crosstalk between the extrinsic and intrinsic apoptotic pathways. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20935064&form=6&db=m Non-Steroidal Anti-Inflammatory Drugs and Prostate Cancer Risk in the VITamins And Lifestyle (VITAL) Cohort. diagnostic usage,therapeutic application,unassigned 4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21053205&form=6&db=m Regression of prostate tumors upon combination of hormone ablation therapy and celecoxib in vivo. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21090342&form=6&db=m [Expression of COX-2 in different human prostate cancer cell lines and its significance]. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21103921&form=6&db=m Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21273602&form=6&db=m Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21308720&form=6&db=m Associations between arachidonic acid metabolism gene polymorphisms and prostate cancer risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,2,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21430074&form=6&db=m Enforced Expression of miR-101 inhibits prostate cancer cell growth by modulating cyclooxygenase-2 pathway in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21430300&form=6&db=m Genetic Polymorphisms in Inflammation Pathway Genes and Prostate Cancer Risk. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21456064&form=6&db=m Regression of prostate tumors upon combination of hormone ablation therapy and celecoxib in vivo. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21556211&form=6&db=m Cyclooxygenase-2 overexpression in chronic inflammation associated with benign prostatic hyperplasia: is it related to apoptosis and angiogenesis of prostate cancer? causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21745389&form=6&db=m Regulation of bombesin-stimulated cyclooxygenase-2 expression in prostate cancer cells. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21764858&form=6&db=m Effect of low-fat diet on plasma levels of NF-{kappa}B-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. unassigned -
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21786090&form=6&db=m p53 and Cyclooxygenase-2 Expression are Directly Associated with Cyclin D1 Expression in Radical Prostatectomy Specimens of Patients with Hormone-Naïve Prostate Cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22023987&form=6&db=m Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22049790&form=6&db=m [Expressions of CD4+ CD25(high) regulatory T cells, TGF-beta 1 and COX-2 in the peripheral blood of prostate cancer patients]. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22060733&form=6&db=m Influence of concurrent medications on outcomes of men with prostate cancer included in the TAX 327 study. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22435969&form=6&db=m Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysis. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22593181&form=6&db=m A local paracrine and endocrine network involving TGF?, Cox-2, ROS, and estrogen receptor ? influences reactive stromal cell regulation of prostate cancer cell motility. therapeutic application,unassigned 1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22635163&form=6&db=m COX-2 inhibitors in prostate cancer treatment--hold your horses? causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735362&form=6&db=m Renal effects of high-dose celecoxib in elderly men with Stage D2 prostate carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22763881&form=6&db=m Overexpression of vasoactive intestinal peptide receptors and cyclooxygenase-2 in human prostate cancer. Analysis of potential prognostic relevance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22782583&form=6&db=m Meta-analysis of epidemiological studies demonstrates significant association of PTGS2 polymorphism rs689470 and no significant association of rs20417 with prostate cancer. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22966331&form=6&db=m Effect of endothelin-1 on cyclooxygenase-2 expression in human hormone refractory prostate cancer cells. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23053989&form=6&db=m Systematic review and meta-analysis of COX-2 expression and polymorphisms in prostate cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23079475&form=6&db=m Use of aspirin, but not other non-steroidal anti-inflammatory drugs is associated with decreased prostate cancer risk at the population level. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23167625&form=6&db=m Selective COX-2 inhibitor (celecoxib) decreases cellular growth in prostate cancer cell lines independent of p53. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23342084&form=6&db=m Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23515290&form=6&db=m TGF-? Effects on Prostate Cancer Cell Migration and Invasion Are Mediated by PGE2 through Activation of PI3K/AKT/mTOR Pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23535188&form=6&db=m Mechanisms of the anti-proliferative and anti-inflammatory effects of the herbal fixed combination STW 5 (Iberogast(®)) on colon adenocarcinoma (HT29) cells in vitro. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23536554&form=6&db=m Interleukin-1? promotes skeletal colonization and progression of metastatic prostate cancer cells with neuroendocrine features. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23548966&form=6&db=m Association between the 8473T>C polymorphism of PTGS2 and prostate cancer risk: a metaanalysis including 24,716 subjects. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23646189&form=6&db=m Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23922175&form=6&db=m Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24073305&form=6&db=m Lack of Association between COX-2 Staining Level and Biochemical Recurrence Following Salvage Radiation Therapy for Recurrent Prostate Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127882&form=6&db=m Cyclooxygenase-2 inhibitor suppresses tumour progression of prostate cancer bone metastases in nude mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24155892&form=6&db=m Combined inhibition of epidermal growth factor receptor and cyclooxygenase-2 leads to greater anti-tumor activity of docetaxel in advanced prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24203817&form=6&db=m Cyclooxygenase 2 genotypes influence prostate cancer susceptibility in Japanese Men. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24246211&form=6&db=m Adding Cyclooxygenase-2 inhibitor to alpha blocker for patients with benign prostate hyperplasia and elevated serum prostate specific antigen could not improve prostate biopsy detection rate but improve lower urinary tract symptoms. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24291175&form=6&db=m Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24518515&form=6&db=m EP2 signaling mediates suppressive effects of celecoxib on androgen receptor expression and cell proliferation in prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24636974&form=6&db=m Tissue Biomarkers for Prognosis of prostate cancer: A Systematic Review and Meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24802614&form=6&db=m COX-2 inhibitors arrest prostate cancer cell cycle progression by down-regulation of kinetochore/centromere proteins. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25118473&form=6&db=m Breast cancer--new aspects of tumor biology: are calcitriol and cyclooxygenase-2 possible targets for breast cancer? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25202054&form=6&db=m LLW-3-6 and celecoxib impacts growth in prostate cancer cells and subcellular localization of COX-2. ongoing research,unassigned 3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25305352&form=6&db=m Differential expression and regulation of vitamin D hydroxylases and inflammatory genes in prostate stroma and epithelium by 1,25-dihydroxyvitamin D in men with prostate cancer and an in vitro model. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25446255&form=6&db=m VIP induces NF-?B1-nuclear localisation through different signalling pathways in human tumour and non-tumour prostate cells. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26125280&form=6&db=m Predictive value of Cyclooxygenase-2 over expression for identifying prostate cancer from benign prostatic hyperplasia in prostate biopsy specimens. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26535654&form=6&db=m Lack of association between the cyclooxygenase 2 -765G>C polymorphism and prostate cancer risk: a meta-analysis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26728412&form=6&db=m Retraction: Suppression of N-Methyl-N-nitrosourea/Testosterone-Induced Rat Prostate Cancer Growth by Celecoxib: Effects on Cyclooxygenase-2, Cell Cycle Regulation, and Apoptosis Mechanism(s). ongoing research,unassigned 3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26788504&form=6&db=m Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26876900&form=6&db=m New evidence from the Prostate Cancer Prevention Trial may exculpate cyclooxygenase (COX) blockers in erectile dysfunction. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26884961&form=6&db=m Prostaglandin-endoperoxide synthase 2 (PTGS2) rs20417 polymorphism and prostate cancer risk: a meta analysis. diagnostic usage,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26920155&form=6&db=m Cyclooxygenase 2 (rs2745557) Polymorphism and the Susceptibility to Benign Prostate Hyperplasia and Prostate Cancer in Egyptians. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27140699&form=6&db=m Human antigen R is positively associated with malignant aggressiveness via upregulation of cell proliferation, migration, and vascular endothelial growth factors and cyclooxygenase-2 in prostate cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232854&form=6&db=m PSCA, Cox-2, and Ki-67 are independent, predictive markers of biochemical recurrence in clinically localized prostate cancer: a retrospective study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27480340&form=6&db=m Cyclooxygenase-2 (COX-2) inhibition for prostate cancer chemoprevention: double-blind randomised study of pre-prostatectomy celecoxib or placebo. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27486833&form=6&db=m Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27530263&form=6&db=m Prostate cancer: A COX-2 far? unassigned -
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27647999&form=6&db=m Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27900011&form=6&db=m Downregulated microRNA-26a modulates prostate cancer cell proliferation and apoptosis by targeting COX-2. therapeutic application,unassigned 1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28593171&form=6&db=m Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28941222&form=6&db=m Nonsteroidal anti-inflammatory drugs (NSAIDs) and prostate cancer risk: results from the EPICAP study. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28945110&form=6&db=m Effects of Obesity on the Regulation of Macrophage Population in the Prostate Tumor Microenvironment. diagnostic usage,unassigned 1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29087091&form=6&db=m [ETIOLOGY OF PROSTATE CANCER]. causal interaction,unassigned 1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29088783&form=6&db=m Annexin A5 suppresses cyclooxygenase-2 expression by downregulating the protein kinase C-?-nuclear factor-?B signaling pathway in prostate cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29242151&form=6&db=m Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29531971&form=6&db=m BCL-2 and BCL-XL expression are down-regulated in benign prostate hyperplasia nodules and not affected by finasteride and/or celecoxib. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29599304&form=6&db=m Aspirin in the Management of Patients with Prostate Cancer Undergoing Radiotherapy: Friend or Foe? therapeutic application,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29697282&form=6&db=m The Role of Genetic Variants in the Association between Dietary Acrylamide and Advanced Prostate Cancer in the Netherlands Cohort Study on Diet and Cancer. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29765153&form=6&db=m COX-2 mediates pro-tumorigenic effects of PKC? in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30038944&form=6&db=m The impact of celecoxib on outcomes in advanced prostate cancer patients undergoing androgen deprivation therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30312731&form=6&db=m Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367494&form=6&db=m PROSTAGLANDIN E2 stimulates cancer-related phenotypes in prostate cancer PC3 cells through cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30552915&form=6&db=m Resveratrol promotes apoptosis through the induction of dual specificity phosphatase 1 and sensitizes prostate cancer cells to cisplatin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30673592&form=6&db=m Nanoliposomal formulation encapsulating celecoxib and genistein inhibiting COX-2 pathway and Glut-1 receptors to prevent prostate cancer cell proliferation. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31115550&form=6&db=m Differential gene methylation patterns in cancerous and non?cancerous cells. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31157709&form=6&db=m Aerobic Training and Green Tea Extract Protect against NMU-induced Prostate Cancer. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31626054&form=6&db=m Aerobic Training and Green Tea Extract Protect against N-methyl-N-nitrosourea-induced Prostate Cancer. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31715374&form=6&db=m Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31749848&form=6&db=m Analysis of quality of life after randomized controlled trial of alpha-1 adrenoceptor antagonist alone and in combination with cyclooxygenase-2 inhibitor in patients who underwent low-dose-rate brachytherapy for prostate cancer. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32257976&form=6&db=m Cyclooxygenase-2 inhibitors delay relapse and reduce Prostate Specific Antigen (PSA) velocity in patients treated with radiotherapy for nonmetastatic prostate cancer: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32378433&form=6&db=m Growth Inhibitory and Pro-Apoptotic Effects of Ornamental Pomegranate Extracts in Du145 Human Prostate Cancer Cells. causal interaction,unassigned 1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32588515&form=6&db=m Biochemical control of the combination of cyclooxygenase-2 inhibitor and 125 I-brachytherapy for prostate cancer: Post hoc analysis of an open-label controlled randomized trial. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33076397&form=6&db=m Inflammation as a Driver of Prostate Cancer Metastasis and Therapeutic Resistance. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117682&form=6&db=m Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33360326&form=6&db=m The multiple effects of aspirin in prostate cancer patients. causal interaction,unassigned 4,0
1.14.99.1 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34110482&form=6&db=m Production, structural and biochemical characterization relevant to antitumor property of acidic exopolysaccharide produced from Bacillus sp. NRC5. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16122891&form=6&db=m Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16622306&form=6&db=m COX-1 and -2 expressions in sex-related organs of neonatally estrogen-treated rats and in activated and nonactivated macrophage RAW264.7 cells with phytoestrogen. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18554636&form=6&db=m Intraprostatic botulinum toxin a injection inhibits cyclooxygenase-2 expression and suppresses prostatic pain on capsaicin induced prostatitis model in rat. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18817354&form=6&db=m [Xiaojin Wan inhibits the expression of COX-2 in prostate tissues of prostatitis pain rats] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22207703&form=6&db=m Chronic Pelvic Pain Syndrome (CPPS) and Semen Quality of Korean Men in Their 4th Decade. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23862231&form=6&db=m [Correlation of IPSS with IL-8 and COX-2 levels in patients with benign prostatic hyperplasia and prostatitis]. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24256126&form=6&db=m Prostatic protective nature of the flavonoid-rich fraction from Cyclosorus acuminatus on carrageenan-induced non-bacterial prostatitis in rat. ongoing research,unassigned 2,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24908280&form=6&db=m Correlation study of chronic nonbacterial prostatitis with the levels of COX-2 and PGE2 in prostatic secretion. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25248630&form=6&db=m The alteration of inflammatory markers and apoptosis on chronic prostatitis induced by estrogen and androgen. causal interaction,unassigned 4,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30402808&form=6&db=m Prognostic and Clinic-Pathological Significances of SCF and COX-2 Expression in Inflammatory and Malignant Prostatic Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30892130&form=6&db=m Overexpression of lncRNA GAS5 suppresses prostatic epithelial cell proliferation by regulating COX-2 in chronic non-bacterial prostatitis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Prostatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31376214&form=6&db=m Extracorporeal shock wave therapy decreases COX-2 by inhibiting TLR4-NF?B pathway in a prostatitis rat model. ongoing research,unassigned 2,0
1.14.99.1 Protein-Energy Malnutrition http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15897385&form=6&db=m Aquagenic wrinkling of the palms in patients with cystic fibrosis homozygous for the delta F508 CFTR mutation. causal interaction,unassigned 4,0
1.14.99.1 protein-tyrosine-phosphatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19890037&form=6&db=m Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2347921&form=6&db=m Predominant functional roles for thromboxane A2 and prostaglandin E2 during late nephrotoxic serum glomerulonephritis in the rat. therapeutic application,unassigned 1,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3081672&form=6&db=m Effect of aspirin and sulindac in rabbit nephrotoxic nephritis. unassigned -
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3111267&form=6&db=m A role for thromboxane in complement-mediated glomerular injury. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10844603&form=6&db=m A selective cyclooxygenase-2 inhibitor decreases proteinuria and retards progressive renal injury in rats. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11849393&form=6&db=m Indomethacin protects permeability barrier from focal segmental glomerulosclerosis serum. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11961014&form=6&db=m Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164875&form=6&db=m Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of diabetes and hypertension. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12640255&form=6&db=m Inhibition of COX-2 prevents hypertension and proteinuria associated with a decrease of 8-iso-PGF2alpha formation in L-NAME-treated rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12649375&form=6&db=m Inhibition of cyclooxygenases reduces complement-induced glomerular epithelial cell injury and proteinuria in passive Heymann nephritis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12816702&form=6&db=m [Renal protective effects of specific cyclooxygenase-2 inhibitor in rats with subtotal renal ablation] causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15717837&form=6&db=m Effects of sodium restriction and cyclooxygenase-2 inhibition on the course of hypertension, proteinuria and cardiac hypertrophy in Ren-2 transgenic rats. ongoing research,unassigned 4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15882262&form=6&db=m Small bowel cyclooxygenase 2 (COX-2) expression in patients with IgA nephropathy. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16756637&form=6&db=m Effect of indomethacin and selective cyclooxygenase-2 inhibitors on proteinuria and renal function in patients with AA type renal amyloidosis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16935907&form=6&db=m Chronic inhibition of NOS-2 ameliorates renal injury, as well as COX-2 and TGF-beta 1 overexpression in 5/6 nephrectomized rats. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17196403&form=6&db=m A selective cyclooxygenase-2 inhibitor decreases transforming growth factor-beta1 synthesis and matrix production in human peritoneal mesothelial cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17890881&form=6&db=m Puromycin Induces Reversible Proteinuric Injury in Transgenic Mice Expressing Cyclooxygenase-2 in Podocytes. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17951998&form=6&db=m Effects of Dietary Salt on Intrarenal Angiotensin System, NAD(P)H Oxidase, COX-2, MCP-1 and PAI-1 Expressions and NF-kappaB Activity in Salt-Sensitive and -Resistant Rat Kidneys. unassigned -
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18037095&form=6&db=m A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18762248&form=6&db=m PGE(2) induces COX-2 expression in podocytes via the EP(4) receptor through a PKA-independent mechanism. therapeutic application,unassigned 2,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19037084&form=6&db=m Selective cyclooxygenase-2 (COX-2) inhibition reduces proteinuria in renal patients. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19194550&form=6&db=m Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19420110&form=6&db=m NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE. causal interaction,unassigned 2,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19656915&form=6&db=m Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney. causal interaction,unassigned 1,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20924284&form=6&db=m Selective Cyclooxygenase-2 Inhibitor Suppresses Renal Thromboxane Production but Not Proliferative Lesions in the MRL/lpr Murine Model of Lupus Nephritis. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21737546&form=6&db=m Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24918154&form=6&db=m Albumin-induced podocyte injury and protection are associated with regulation of COX-2. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24984018&form=6&db=m COX-2 but not mPGES-1 contributes to renal PGE2 induction and diabetic proteinuria in mice with type-1 diabetes. ongoing research,unassigned 2,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31334040&form=6&db=m Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction. causal interaction,unassigned 4,0
1.14.99.1 Proteinuria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31841390&form=6&db=m COX-2-derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease. therapeutic application,unassigned 3,0
1.14.99.1 protoporphyrin ferrochelatase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25104852&form=6&db=m Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. causal interaction,unassigned 4,0
1.14.99.1 Pruritus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1490622&form=6&db=m Mast cell disease. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Pruritus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8858986&form=6&db=m Characterization of receptor subtypes involved in prostanoid-induced conjunctival pruritus and their role in mediating allergic conjunctival itching. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Pruritus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15715611&form=6&db=m Reduction of opioid-related adverse events using opioid-sparing analgesia with COX-2 inhibitors lacks documentation: a systematic review. therapeutic application,unassigned 3,0
1.14.99.1 Pruritus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26647567&form=6&db=m [Effect of preoperative cyclooxygenase-2 inhibitor for postoperative pain in patients after total knee arthroplasty: a meta-analysis]. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Pseudomyxoma Peritonei http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16427185&form=6&db=m COX-2 expression in pseudomyxoma peritonei. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Pseudorabies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15542648&form=6&db=m Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7946375&form=6&db=m Testing of lipoxygenase inhibitors, cyclooxygenase inhibitors, drugs with immunomodulating properties and some reference antipsoriatic drugs in the modified mouse tail test, an animal model of psoriasis. therapeutic application,unassigned 4,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238591&form=6&db=m Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. causal interaction,unassigned 3,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11860351&form=6&db=m Non steroidal anti-inflammatory and anti-allergy agents. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15914323&form=6&db=m Effect of ginsenoside Rb1 and compound K in chronic oxazolone-induced mouse dermatitis. ongoing research,unassigned 2,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930749&form=6&db=m Effect of chunghyuldan in chronic oxazolone-induced mouse dermatitis. ongoing research,unassigned 2,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16516815&form=6&db=m Co-localization of COX-2, CYP4F8, and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions. ongoing research,unassigned 4,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18225391&form=6&db=m Vascular endothelial growth factor, vascular endothelial growth factor receptor-3 and cyclooxygenase-2 expression in psoriasis. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18248470&form=6&db=m Perioperative management of medications for psoriasis and psoriatic arthritis: a review for the dermasurgeon. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18690928&form=6&db=m The role of the New Zealand Intensive Medicines Monitoring Programme in identification of previously unrecognised signals of adverse drug reactions. therapeutic application,unassigned 1,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19405952&form=6&db=m Apigenin, a nonmutagenic dietary flavonoid suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20107721&form=6&db=m Psoriasis and hypertension: a case-control study. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20538798&form=6&db=m Human fibroblasts support the expansion of IL-17-producing T cells via up-regulation of IL-23 production by dendritic cells. causal interaction,unassigned 3,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23454135&form=6&db=m Antiproliferative effect of two novel COX-2 inhibitors on human keratinocytes. therapeutic application,unassigned 4,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25278440&form=6&db=m Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. unassigned -
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26748901&form=6&db=m Expression of pro-angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30760013&form=6&db=m Inflammasome Signaling and Impaired Vascular Health in Psoriasis. ongoing research,unassigned 3,0
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32131611&form=6&db=m Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis Via COX-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,1
1.14.99.1 Psoriasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34314841&form=6&db=m Preclinical study of methotrexate-based hydrogels versus surfactant based liquid crystal systems on psoriasis treatment. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17444036&form=6&db=m [Blood vessel multiply and significance of expression of Cox-2, VEGF in pterygium] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17515883&form=6&db=m Cyclooxygenase 2 expression in pterygium. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18050111&form=6&db=m Cyclooxygenase-2 expression in primary and recurrent pterygium. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18201523&form=6&db=m [Expression of cyclooxygenase-2 in pterygium and effects of selective cyclooxygenase-2 inhibitor on human pterygium fibroblasts] causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18579985&form=6&db=m Cyclooxygenase-2 expression in primary and recurrent pterygium. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18609497&form=6&db=m Comment on papper: Cyclooxygenase-2 expression in primary and recurrent pterygium. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19247455&form=6&db=m Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22219642&form=6&db=m Cyclooxygenase-2-expressing macrophages in human pterygium co-express vascular endothelial growth factor. ongoing research,unassigned 4,0
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26903201&form=6&db=m The Influence of Chemokine CXCR4 and Cyclooxygenase-2 in the Recurrence of Pterygium. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28221652&form=6&db=m Comment on Cyclooxygenase-2 expression in primary and recurrent pterygium and Authors' response. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152967&form=6&db=m Chemokine CXCR-4 and cyclooxygenase-2 in the pathogenesis of pterygium causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29285278&form=6&db=m Relationship between expression of cyclooxygenase 2 and neovascularization in human pterygia. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34305615&form=6&db=m Effect of a Topical Nonsteroidal Anti-Inflammatory Drug (0.1% Pranoprofen) on VEGF and COX-2 Expression in Primary Pterygium. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,4,3
1.14.99.1 Pterygium http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34483947&form=6&db=m Corrigendum: Effect of a Topical Nonsteroidal Anti-Inflammatory Drug (0.1% Pranoprofen) on VEGF and COX-2 Expression in Primary Pterygium. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1627331&form=6&db=m Post-ischemic rupture of the anterior papillary muscle of the right ventricle associated with persistent pulmonary hypertension of the newborn: a case report. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2496411&form=6&db=m Indomethacin and LY171883 modify porcine cardiopulmonary responses to leukotrienes. unassigned -
1.14.99.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20844610&form=6&db=m Prostacyclin therapy for pulmonary arterial hypertension. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23681850&form=6&db=m Cyclooxygenase-2 expression in lung in patients with congenital heart malformations and pulmonary arterial hypertension. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24337227&form=6&db=m H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Pulmonary Arterial Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29449428&form=6&db=m A novel piperidine identified by stem cell-based screening attenuates pulmonary arterial hypertension by regulating BMP2 and PTGS2 levels. causal interaction,unassigned 4,0
1.14.99.1 Pulmonary Atelectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3104282&form=6&db=m Lipoxygenase and cyclooxygenase blockade by BW 755C enhances pulmonary hypoxic vasoconstriction. ongoing research,unassigned 3,0
1.14.99.1 Pulmonary Atelectasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9516203&form=6&db=m Improved oxygenation with prostaglandin F2alpha with and without inhaled nitric oxide in dogs. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8087135&form=6&db=m Chronic bronchitis: reflex on the pulmonary circulation. causal interaction,unassigned 4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10673210&form=6&db=m Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12169581&form=6&db=m Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15127973&form=6&db=m Cyclooxygenase-2 is up-regulated in lung parenchyma of chronic obstructive pulmonary disease and down-regulated in idiopathic pulmonary fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15949313&form=6&db=m [Expressions of cyclooxygenase-2 and matrix metalloproteinase-2 and airflow obstruction in patients with chronic obstructive pulmonary disease] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,2
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16192367&form=6&db=m Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17255567&form=6&db=m Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke. unassigned -
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18191873&form=6&db=m Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18699805&form=6&db=m Enhanced levels of prostaglandin E2 and matrix metalloproteinase-2 correlate with the severity of airflow limitation in stable COPD. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19897740&form=6&db=m Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20522791&form=6&db=m Reduced miR-146a increases prostaglandin E? in chronic obstructive pulmonary disease fibroblasts. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20724130&form=6&db=m The cyclooxygenase-2-765C promoter polymorphism protects against the development of chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21655952&form=6&db=m Functional polymorphism of cyclooxygenase-2 gene (G-765C) in chronic obstructive pulmonary disease patients. ongoing research,unassigned 3,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21798652&form=6&db=m Cyclooxigenase-2 Levels are Increased in the Lung Tissue and Bronchial Tumors of Patients with Chronic Obstructive Pulmonary Disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22100366&form=6&db=m Cyclooxygenase-2 -765G>C polymorphism is associated with C-reactive protein levels in resistant smokers but not in chronic obstructive pulmonary disease patients. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23328527&form=6&db=m The cyclooxygenase-2-prostaglandin e2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts. ongoing research,unassigned 1,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23786928&form=6&db=m Cyclooxygenase 2 1195G > A polymorphism is associated with chronic obstructive pulmonary disease in Japanese and Chinese patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24472607&form=6&db=m The NF-?B family member RelB regulates microRNA miR-146a to suppress cigarette smoke-induced COX-2 protein expression in lung fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25736434&form=6&db=m Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways. unassigned -
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25767384&form=6&db=m Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25943190&form=6&db=m Decreased expression of the NF-?B family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26926362&form=6&db=m Prostaglandin E2 possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26965288&form=6&db=m Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD. unassigned -
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28066584&form=6&db=m Overexpression of farnesoid X receptor in small airways contributes to epithelial to mesenchymal transition and COX-2 expression in chronic obstructive pulmonary disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28203404&form=6&db=m The role of cyclooxygenase-2 in the protection against apoptosis in vascular endothelial cells induced by cigarette smoking. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449186&form=6&db=m The risk of lower gastrointestinal bleeding in low-dose aspirin users. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28749959&form=6&db=m Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28834088&form=6&db=m VEGF synthesis is induced by prostacyclin and TGF-? in distal lung fibroblasts from COPD patients and control subjects: Implications for pulmonary vascular remodelling. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29756563&form=6&db=m Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29961171&form=6&db=m Curcumin Attenuates Airway Inflammation and Airway Remolding by Inhibiting NF-?B Signaling and COX-2 in Cigarette Smoke-Induced COPD Mice. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30390648&form=6&db=m Dietary ?-6 polyunsaturated fatty acid arachidonic acid increases inflammation, but inhibits ECM protein expression in COPD. unassigned -
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30641209&form=6&db=m Associations of the NRF2/KEAP1 pathway and antioxidant defense gene polymorphisms with chronic obstructive pulmonary disease. diagnostic usage,ongoing research,unassigned 1,1,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31419078&form=6&db=m Identification of differentially expressed genes and signaling pathways in chronic obstructive pulmonary disease via bioinformatic analysis. causal interaction,unassigned 2,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32448093&form=6&db=m Anti-inflammatory action of herbal medicine comprised of Scutellaria baicalensis and Chrysanthemum morifolium. unassigned -
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32920133&form=6&db=m Active ingredients targeting Nrf2 in the Mongolian medicine Qiwei Putao powder: Systematic pharmacological prediction and validation for chronic obstructive pulmonary disease treatment. causal interaction,unassigned 1,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33488748&form=6&db=m Determining Pharmacological Mechanisms of Chinese Incompatible Herbs Fuzi and Banxia in Chronic Obstructive Pulmonary Disease: A Systems Pharmacology-Based Study. therapeutic application,unassigned 2,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33545665&form=6&db=m Polymorphisms rs2745557 in PTGS2 and rs2075797 in PTGER2 are associated with the risk of chronic obstructive pulmonary disease development in a Tunisian cohort. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33729612&form=6&db=m Pulmonary surfactant-associated protein B regulates prostaglandin-endoperoxide synthase-2 and inflammation in chronic obstructive pulmonary disease. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,2,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34211564&form=6&db=m Molecular Mechanism of Xixin-Ganjiang Herb Pair Treating Chronic Obstructive Pulmonary Disease-Integrated Network Pharmacology and Molecular Docking. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Pulmonary Disease, Chronic Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34221077&form=6&db=m The Clinical Efficiency and the Mechanism of Sanzi Yangqin Decoction for Chronic Obstructive Pulmonary Disease. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2127085&form=6&db=m [Late effects of acute inhibition of cyclooxygenase on tissue gas exchange in experimental pulmonary edema lesions] causal interaction,ongoing research,therapeutic application,unassigned 1,4,2,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2507502&form=6&db=m Edema from cyclooxygenase products of endogenous arachidonic acid in isolated lung. diagnostic usage,unassigned 3,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3693233&form=6&db=m Alpha-thrombin-induced pulmonary vasoconstriction. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6433362&form=6&db=m Inhibition of cyclooxygenase production does not prevent arachidonate from increasing extravascular lung water and albumin in an isolated dog lung. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6511865&form=6&db=m Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. unassigned -
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6771084&form=6&db=m Histamine receptor and prostaglandin synthetase blockers in ethchlorvynol-induced pulmonary edema in canines. ongoing research,unassigned 2,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7129977&form=6&db=m Indomethacin blunts ethchlorvynol-induced pulmonary hypertension but not pulmonary edema. therapeutic application,unassigned 1,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7713845&form=6&db=m BW-755C diminishes smoke-induced pulmonary edema. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8002544&form=6&db=m Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,1,2,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14704790&form=6&db=m PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18097066&form=6&db=m Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Pulmonary Edema http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21818760&form=6&db=m Ethyl pyruvate protects rats from phosgene-induced pulmonary edema by inhibiting cyclooxygenase2 and inducible nitric oxide synthase expression. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1554206&form=6&db=m Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3619983&form=6&db=m [Antithrombotic action of benzydamine] therapeutic application,unassigned 1,0
1.14.99.1 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11395221&form=6&db=m Contribution of pulmonary vasoconstriction to haemodynamic instability after acute pulmonary embolism. Implications for treatment? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12639842&form=6&db=m Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Pulmonary Embolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17219957&form=6&db=m Influence of L-arginine on the expression of eNOS and COX2 in experimental pulmonary thromboembolism. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823297&form=6&db=m Expression of cyclooxygenase-2 in human lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11290559&form=6&db=m Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. causal interaction,unassigned 4,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12163371&form=6&db=m Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis. causal interaction,unassigned 4,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15286697&form=6&db=m Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,3,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15509536&form=6&db=m Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17496151&form=6&db=m Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21979415&form=6&db=m Serum concentrations of cyclooxygenase-2 in patients with systemic sclerosis: association with lower frequency of pulmonary fibrosis. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26122220&form=6&db=m MELATONIN ALLEVIATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS IN MICE. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26744410&form=6&db=m Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29786110&form=6&db=m Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review). causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30784938&form=6&db=m Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. unassigned -
1.14.99.1 Pulmonary Fibrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34320042&form=6&db=m Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Pulpitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11487130&form=6&db=m An immunohistological study on cyclooxygenase-2 in human dental pulp. causal interaction,unassigned 4,0
1.14.99.1 Pulpitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12017180&form=6&db=m Differential regulation of interleukin-6 and inducible cyclooxygenase gene expression by cytokines through prostaglandin-dependent and -independent mechanisms in human dental pulp fibroblasts. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Pulpitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33791868&form=6&db=m Effect of non-steroidal anti-inflammatory drugs on pulpal and periapical inflammation induced by lipopolysaccharide. therapeutic application,unassigned 4,0
1.14.99.1 Purpura, Thrombocytopenic, Idiopathic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27715371&form=6&db=m Flow cytometric analysis of platelet cyclooxygenase-1 and -2 and surface glycoproteins in patients with immune thrombocytopenia and healthy individuals. causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Pyelonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6447737&form=6&db=m Role of suppressor cells in experimental pyelonephritis. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Pyelonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15786824&form=6&db=m COX-2 inhibitor induced anuric renal failure in a previously healthy young woman. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Pyelonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16912484&form=6&db=m Effect of a Selective Cyclooxygenase-2 Inhibitor on Renal Scarring. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Pyelonephritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20510442&form=6&db=m Renal tissue damage after experimental pyelonephritis: role of antioxidants and selective cyclooxygenase-2 inhibitors. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Pyometra http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19754568&form=6&db=m Prostaglandin synthesis genes are differentially transcripted in normal and pyometra endometria of bitches. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Pyometra http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26596635&form=6&db=m Positive correlation between patency and mRNA levels for cyclooxygenase-2 and prostaglandin E synthase in the uterine cervix of bitches with pyometra. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0
1.14.99.1 Pyometra http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27288342&form=6&db=m Identifying diagnostic endocrine markers and changes in endometrial gene expressions during pyometra in cats. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0
1.14.99.1 Pyometra http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28395328&form=6&db=m Cystic endometrial hyperplasia-pyometra syndrome in bitches: identification of hemodynamic, inflammatory, and cell proliferation changes. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Radiation Fibrosis Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15685827&form=6&db=m Celecoxib and radiation therapy in non-small-cell lung cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Radiation Pneumonitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1886988&form=6&db=m Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis. therapeutic application,unassigned 4,0
1.14.99.1 Radicular Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12406380&form=6&db=m Immunohistochemical localization of cyclooxygenase-2 in radicular cysts. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Radicular Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17940572&form=6&db=m [Expression of cyclooxygenase 2 mRNA in apical periodontitis.] causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Radicular Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30477664&form=6&db=m Immunohistochemical Analysis of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha in Periapical Lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Radicular Cyst http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30770599&form=6&db=m The fibroblast of radicular cyst facilitate osteoclastogenesis via the autocrine of Fibronectin containing extra domain A. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Radiculopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192259&form=6&db=m Cyclooxygenase-2 inhibitor SC-236 attenuates mechanical allodynia following nerve root injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Radiculopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11193500&form=6&db=m The role of cyclooxygenase-2 and inflammatory cytokines in pain induction of herniated lumbar intervertebral disc. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Radiculopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11918320&form=6&db=m Epidural injection of cyclooxygenase-2 inhibitor attenuates pain-related behavior following application of nucleus pulposus to the nerve root in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Radiculopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16094269&form=6&db=m Effect of mechanical compression on the lumbar nerve root: localization and changes of intraradicular inflammatory cytokines, nitric oxide, and cyclooxygenase. causal interaction,unassigned 3,0
1.14.99.1 Radiculopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30086368&form=6&db=m Pre-treatment with Meloxicam Prevents the Spinal Inflammation and Oxidative Stress in DRG Neurons that Accompany Painful Cervical Radiculopathy. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9820411&form=6&db=m Rectal cancer after sulindac therapy for a sporadic adenomatous colonic polyp. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10517910&form=6&db=m Differential expression of cyclooxygenase 2 in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11514566&form=6&db=m A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12003384&form=6&db=m Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16199309&form=6&db=m Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213106&form=6&db=m COX-2 verexpression in pretreatment biopsies predicts response of rectal cancers to neoadjuvant radiochemotherapy. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16317264&form=6&db=m Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16573762&form=6&db=m Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17308999&form=6&db=m Absence of cyclooxygenase-2 protein expression is a predictor of tumor regression in rectal cancer treated with preoperative short-term chemoradiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17504996&form=6&db=m Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17687192&form=6&db=m Prognostic significance of vascular endothelial growth factor and cyclooxygenase-2 in patients with rectal cancer treated with preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,1,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18064474&form=6&db=m A COX-2 inhibitor combined with chemoradiation of locally advanced rectal cancer: a phase II trial. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,4
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18392637&form=6&db=m The role of COX-2 in rectal cancer treated with preoperative radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015468&form=6&db=m Cyclooxygenase-2 expression in pretreatment biopsy as a predictor of tumor responses after preoperative chemoradiation in rectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19296118&form=6&db=m A COX-2 inhibitor combined with chemoradiation of locally advanced rectal cancer. therapeutic application,unassigned 4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19747744&form=6&db=m Double blind randomized phase II study with radiation+5-fluorouracil+/-celecoxib for resectable rectal cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424389&form=6&db=m High survivin expression as a predictor of poor response to preoperative chemoradiotherapy in locally advanced rectal cancer. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21689364&form=6&db=m The use of molecular markers as a method to predict the response to neoadjuvant therapy for advanced stage rectal adenocarcinoma. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21825889&form=6&db=m Pretreatment CD133 and Cyclooxygenase-2 Expression as the Predictive Markers of the Pathological Effect of Chemoradiotherapy in Rectal Cancer Patients. diagnostic usage,unassigned 3,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22024062&form=6&db=m Tissue microarrays in chinese human rectal cancer: study of expressions of the tumor-associated genes. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22678777&form=6&db=m PTGS1, PTGS2, ALOX5, ALOX12, ALOX15, and FLAP SNPs: interaction with fatty acids in colon cancer and rectal cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23787217&form=6&db=m Pretreatment Expression of 13 Molecular Markers as a Predictor of Tumor Responses After Neoadjuvant Chemoradiation in Rectal Cancer. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23801169&form=6&db=m Clinical significance of VEGFR-2 and (18)F-FDG PET/CT SUVmax pretreatment score in predicting the long-term outcome of patients with locally advanced rectal cancer treated with neoadjuvant therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24022467&form=6&db=m COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25907945&form=6&db=m [Perioperative immunomodulatory therapy does not decrease postoperative recurrence rate of rectal cancer]. unassigned -
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26680965&form=6&db=m Expression of Cyclooxygenase-2 and Tumor Microvessel Density in Colorectal Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26883667&form=6&db=m Metabolic and molecular relative percentage coreduction in patients with locally advanced rectal cancer treated with neoadjuvant therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,1,2
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27590647&form=6&db=m [Neoadiuvant teleradiotherapy decreases cancer tissue and serum concentration of prostaglandin E2 and cyclooxygenase-2 expression in patients with rectal cancer]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27591442&form=6&db=m [Neoadiuvant teleradiotherapy decreases cancer tissue and serum concentration of prostaglandin E2 and cyclooxygenase-2 expression in patients with rectal cancer]. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28485348&form=6&db=m The role of COX-2 and Ki-67 over-expression in the prediction of pathologic response of rectal cancer to neoadjuvant chemoradiation therapy. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28601236&form=6&db=m Role of cyclooxygenase-2 inhibitors in the survival outcome of colorectal cancer patients: A population-based cohort study. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29257846&form=6&db=m POLYMORPHISM OF THE COX-2 GENE AND SUSCEPTIBILITY TO COLON AND RECTAL CANCER. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32026629&form=6&db=m Predictive immunohistochemical features for tumour response to chemoradiotherapy in rectal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Rectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33123477&form=6&db=m Expressions of miR-302a, miR-105, and miR-888 Play Critical Roles in Pathogenesis, Radiotherapy, and Prognosis on Rectal Cancer Patients: A Study From Rectal Cancer Patients in a Swedish Rectal Cancer Trial of Preoperative Radiotherapy to Big Database Analyses. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Renal Artery Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11133522&form=6&db=m Acute upregulation of COX-2 by renal artery stenosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Renal Artery Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11967238&form=6&db=m Epithelial COX-2 expression is not regulated by nitric oxide in rodent renal cortex. ongoing research,unassigned 3,0
1.14.99.1 Renal Artery Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12441308&form=6&db=m General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system. unassigned -
1.14.99.1 Renal Artery Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15372104&form=6&db=m Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3091372&form=6&db=m Acute effects of clometacin on renal prostaglandin biosynthesis in healthy subjects. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6952058&form=6&db=m Acute intrinsic renal failure induced by indomethacin: role of prostaglandin synthetase inhibition. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10516203&form=6&db=m Potassium channel-mediated vasorelaxation is impaired in experimental renal failure. therapeutic application,unassigned 3,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11130355&form=6&db=m COX-2 inhibitors and renal failure: the triple whammy revisited. therapeutic application,unassigned 3,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11549912&form=6&db=m Acute, anuric renal failure associated with two doses of a cyclooxygenase-2 inhibitor. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11550988&form=6&db=m Nephrotoxicity of selective COX-2 inhibitors. diagnostic usage,therapeutic application,unassigned 3,3,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11728945&form=6&db=m Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors. causal interaction,unassigned 4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11880319&form=6&db=m Angiotensin II stimulates cyclooxygenase-2 mRNA expression in renal tissue from rats with kidney failure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12021530&form=6&db=m Subtotal nephrectomy stimulates cyclooxygenase 2 expression and prostacyclin synthesis in the rat remnant kidney. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12224048&form=6&db=m Contribution of prostaglandin D2 synthase to progression of renal failure and dialysis dementia. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,1
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12428686&form=6&db=m Renal pathology resulting from PGHS-2 gene ablation in DBA/B6 mice. ongoing research,unassigned 4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14681341&form=6&db=m Pharmacokinetics of etoricoxib in patients with renal impairment. ongoing research,unassigned 1,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14993496&form=6&db=m Acute renal failure and hyperkalaemia associated with cyclooxygenase-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15105772&form=6&db=m [Renal and cardiovascular effects of non-steroidal anti-inflammatories and selective cox 2 inhibitors] therapeutic application,unassigned 4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15283770&form=6&db=m The renin-angiotensin system in kidney development: role of COX-2 and adrenal steroids. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15613621&form=6&db=m Influence of genetic background and gender on hypertension and renal failure in COX-2-deficient mice. ongoing research,unassigned 4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15625247&form=6&db=m Do cyclooxygenase-2 knockout mice have primary hyperparathyroidism? causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15723448&form=6&db=m Effects of celecoxib and naproxen on renal function in nonazotemic patients with cirrhosis and ascites. therapeutic application,unassigned 4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15741608&form=6&db=m Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infections. ongoing research,unassigned 2,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15786824&form=6&db=m COX-2 inhibitor induced anuric renal failure in a previously healthy young woman. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15813652&form=6&db=m Cyclo-oxygenase-2 inhibitors: when should they be used in the elderly? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16306743&form=6&db=m Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16335308&form=6&db=m [Do selective COX-2 inhibitors have adverse renal and cardiovascular effects?] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17469317&form=6&db=m [Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17584101&form=6&db=m COX-2: friend or foe? causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19471752&form=6&db=m [Specific cyclooxygenase-2 inhibitor analgesics: therapeutic advances.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19789943&form=6&db=m Effects of selective Cox-2 inhibitor, rofecoxib, alone or combination with furosemide on renal functions and renal Cox-2 expression in rats. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19912740&form=6&db=m Effects of No.2 Renal Failure Recipe on expressions of cyclooxygenase-2 and -1 mRNAs in rats with chronic renal failure. ongoing research,unassigned 4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20498929&form=6&db=m [Nonsteroidal anti-inflammatory drugs: cardiovascular, cerebrovascular and renal effects] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20552550&form=6&db=m Involvement of endogenous prostaglandin E2 in tubular epithelial regeneration through inhibition of apoptosis and epithelial-mesenchymal transition in cisplatin-induced rat renal lesions. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21373319&form=6&db=m Etoricoxib-induced life-threatening hyperkalemia and acute kidney dysfunction against the background of telmisartan and a low sodium diet. unassigned -
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22031851&form=6&db=m Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. ongoing research,unassigned 2,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22119250&form=6&db=m Cyclooxygenase-2 and kidney failure. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23243456&form=6&db=m Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney. causal interaction,unassigned 1,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24489896&form=6&db=m Design and optimization of PLGA-based diclofenac loaded nanoparticles. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28274925&form=6&db=m Salt supplementation ameliorates developmental kidney defects in COX-2-/- mice. causal interaction,unassigned 4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31531703&form=6&db=m [Treatment of rheumatic disease with renal insufficiency]. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33159018&form=6&db=m Cyclooxygenase-2/sclerostin mediates TGF-?1-induced calcification in vascular smooth muscle cells and rats undergoing renal failure. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1582443&form=6&db=m Thromboxane mediates glomerular haemodynamics in a model of chronic glomerular disease. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6270738&form=6&db=m The effect of prostaglandin synthetase inhibitors on renal function: studies in normal rats during sodium or water diuresis and in rats with chronic renal insufficiency. ongoing research,unassigned 4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11695250&form=6&db=m COX-2 inhibitors and the kidney. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16343480&form=6&db=m The protective effect of prostacyclin on adriamycin-induced apoptosis in rat renal tubular cells. therapeutic application,unassigned 4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17349452&form=6&db=m NSAID use and progression of chronic kidney disease. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17537981&form=6&db=m Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cy rats with inherited kidney disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20671216&form=6&db=m A maladaptive role for EP4 receptors in podocytes. causal interaction,unassigned 4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22244709&form=6&db=m A comparative study of chronic kidney disease in dogs and cats: Induction of cyclooxygenases. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22699456&form=6&db=m Influence of creatinine versus glomerular filtration rate on non-steroidal anti-inflammatory drug prescriptions in chronic kidney disease. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23305077&form=6&db=m Celecoxib modifies glomerular basement membrane, mesangium and podocytes in OVE26 mice, but ibuprofen is more detrimental. therapeutic application,unassigned 4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25733239&form=6&db=m Thromboxane Prostanoid Receptors Enhance Contractions, Endothelin-1 and Oxidative Stress in Microvessels From Mice With Chronic Kidney Disease. unassigned -
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25955147&form=6&db=m The renal effects of NSAIDs in dogs. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27853386&form=6&db=m Selective cyclooxygenase-2 inhibitor use and progression of renal function in patients with chronic kidney disease: a single-center retrospective cohort study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27892876&form=6&db=m Low expression of cyclooxygenase-2 in chronic kidney disease in young dogs. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28449186&form=6&db=m The risk of lower gastrointestinal bleeding in low-dose aspirin users. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30366771&form=6&db=m Risk factors for upper gastrointestinal bleeding among aspirin users: An old issue with new findings from a population-based cohort study. causal interaction,unassigned 4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900402&form=6&db=m Inhibition of cyclooxygenase metabolite production attenuates ischemia-reperfusion lung injury. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9626852&form=6&db=m Cyclooxygenase inhibition aggravates ischemia-reperfusion injury in the perfused guinea pig heart: involvement of isoprostanes. therapeutic application,unassigned 1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9749846&form=6&db=m Thromboxane A2 in postischemic acute compartmental syndrome. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10884021&form=6&db=m Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury? therapeutic application,unassigned 1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11120183&form=6&db=m The effect of cyclooxygenase 2 inhibitor (FK3311) on ischemia-reperfusion injury with hepatectomy in dogs. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192923&form=6&db=m The effect of cyclooxygenase-2 inhibitor FK3311 on ischemia-reperfusion injury in a canine total hepatic vascular exclusion model. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11267104&form=6&db=m Selective cyclooxygenase-2 inhibitor ameliorates warm ischemia-reperfusion injury of the canine liver. therapeutic application,unassigned 4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11516201&form=6&db=m The effect of a selective cyclooxygenase-2 inhibitor in extended liver resection with ischemia in dogs. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12967936&form=6&db=m Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14696445&form=6&db=m The effects of a selective cyclooxygenase-2 inhibitor on small bowel ischemia-reperfusion injury. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15057408&form=6&db=m Ischemia reperfusion injury in the isolated hemoperfused bovine uterus--a model for the investigation of anti-inflammatory substances? ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15108964&form=6&db=m Isoflurane produces delayed preconditioning against myocardial ischemia and reperfusion injury: role of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15589463&form=6&db=m Cyclooxygenase 1 and/or 2 blockade ameliorates the renal tissue damage triggered by ischemia and reperfusion injury. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15808647&form=6&db=m Study of cyclooxygenase-2 in renal ischemia-reperfusion injury. ongoing research,unassigned 4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15919429&form=6&db=m Blockade of fibronectin-alpha4beta1 adhesive interactions down-regulates cyclooxygenase-2 inducible nitric oxide synthase and prolongs recipient survival in a 24-hour model of cold hepatic ischemia-reperfusion injury. unassigned -
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16713604&form=6&db=m Inhibition of cyclooxygenase-2 improves cardiac function following long-term preservation. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16756774&form=6&db=m Role of cyclooxygenase-2 in myocardial infarction and ischaemia. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17523312&form=6&db=m The effects of a cyclooxygenase-2 inhibitor, FK3311, on total hepatic ischemia-reperfusion injury of the rat. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17562036&form=6&db=m Pyrrolidine dithiocarbamate attenuate shock wave induced MDCK cells injury via inhibiting nuclear factor-kappa B activation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17613692&form=6&db=m Effects of the COX-2 inhibitor FK3311 on ischemia - reperfusion injury in the rat lung. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18339320&form=6&db=m Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes. therapeutic application,unassigned 1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19084534&form=6&db=m Constitutive COX-2 activity in cardiomyocytes confers permanent cardioprotection Constitutive COX-2 expression and cardioprotection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,1
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19671417&form=6&db=m [Effects of scalp acupuncture on acute cerebral ischemia-reperfusion injury in rats.] unassigned -
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19698752&form=6&db=m Cyclooxygenase-2 plays a critical role in retinal ganglion cell death after transient ischemia: Real-time monitoring of RGC survival using Thy-1-EGFP transgenic mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19842898&form=6&db=m The effects of cyclooxygenase (COX)-2 inhibition on ischemia-reperfusion injury in liver transplantation. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917349&form=6&db=m Down-regulation of cyclooxygenase-2 is involved in ischemic postconditioning protection against renal ischemia reperfusion injury in rats. causal interaction,unassigned 2,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20128288&form=6&db=m [Effect of scalp acupuncture on the expression of NF-kappaB mRNA, COX-2 mRNA and their proteins in rats with acute cerebral ischemia-reperfusion injury] causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609232&form=6&db=m A potential protective effect of alpha-tocopherol on vascular complication in spinal cord reperfusion injury in rats. causal interaction,unassigned 4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21995864&form=6&db=m Effect of nonselective and selective COX-2 inhibitors on memory dysfunction, glutathione system, and tumor necrosis factor alpha level against cerebral ischemia reperfusion injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22689528&form=6&db=m Cardiovascular Properties of a Nitric Oxide Releasing Rofecoxib Analogue: Beneficial Anti-hypertensive Activity and Enhanced Recovery in an Ischemic Reperfusion Injury Model. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23229926&form=6&db=m Pretreatment with paricalcitol attenuates inflammation in ischemia-reperfusion injury via the up-regulation of cyclooxygenase-2 and prostaglandin E2. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23337792&form=6&db=m Pioglitazone attenuates myocardial ischemia-reperfusion injury via up-regulation of ERK and COX-2. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24354410&form=6&db=m Temporal determination of lung NO system and COX-2 upregulation following ischemia-reperfusion injury. ongoing research,unassigned 2,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819536&form=6&db=m Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25091992&form=6&db=m Protective effect of indomethacin in renal ischemia-reperfusion injury in mice. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25240714&form=6&db=m Perillyl alcohol improves functional and histological outcomes against ischemia-reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2 and NF-?B in middle cerebral artery occlusion rats. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27135919&form=6&db=m Modulation of the neurological and vascular complications by grape seed extract in a rat model of spinal cord ischemia-reperfusion injury by downregulation of both osteopontin and cyclooxygenase-2. ongoing research,unassigned 4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27254931&form=6&db=m [Mechanism of Musk and Borneol on Inflammatory of Cerebral Ischemia and Reperfusion Injury at Different Time Points of Acute Phase in Rats]. causal interaction,unassigned 4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30155948&form=6&db=m Protective role of hepatocyte cyclooxygenase-2 expression against liver ischemia-reperfusion injury in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930978&form=6&db=m Positive acceleration adaptive training attenuates gastric ischemia-reperfusion injury through COX-2 and PGE2 expression. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31101226&form=6&db=m LncRNA MALAT1 aggravates inflammation response through regulating PTGS2 by targeting miR-26b in myocardial ischemia-reperfusion injury. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734378&form=6&db=m Cyclooxygenase inhibition prior to ventricular fibrillation induced ischemia reperfusion injury impairs survival and outcomes. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32545964&form=6&db=m Gadolinium-Based Neuroprognostic Magnetic Resonance Imaging Agents Suppress COX-2 for Prevention of Reperfusion Injury after Stroke. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32998462&form=6&db=m Novel Combination of COX-2 Inhibitor and Antioxidant Therapy for Modulating Oxidative Stress Associated with Intestinal Ischemic Reperfusion Injury and Endotoxemia. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34324865&form=6&db=m LncRNA-Malat1 down-regulates miR-211-5p expression to promote neuronal damage from cerebral ischemia reperfusion injury. causal interaction,unassigned 4,0
1.14.99.1 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1934328&form=6&db=m Therapeutic intervention in a rat model of adult respiratory distress syndrome: III. Cyclooxygenase pathway inhibition. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2124522&form=6&db=m Therapeutic intervention in a rat model of ARDS: I. Dual inhibition of arachidonic acid metabolism. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6511865&form=6&db=m Elevated concentrations of leukotriene D4 in pulmonary edema fluid of patients with the adult respiratory distress syndrome. unassigned -
1.14.99.1 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9380921&form=6&db=m [Pharmacologic treatment of hypoxemia in adult respiratory distress syndrome] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16443000&form=6&db=m Meta-analysis: Methods, strengths, weaknesses, and political uses. therapeutic application,unassigned 4,0
1.14.99.1 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28356130&form=6&db=m Parecoxib reduced ventilation induced lung injury in acute respiratory distress syndrome. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28794232&form=6&db=m Resolvin D1 Improves the Resolution of Inflammation via Activating NF-?B p50/p50-Mediated Cyclooxygenase-2 Expression in Acute Respiratory Distress Syndrome. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Respiratory Distress Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33013911&form=6&db=m Scientific Rationale for a Bottom-Up Approach to Target the Host Response in Order to Try and Reduce the Numbers Presenting With Adult Respiratory Distress Syndrome Associated With COVID-19. Is There a Role for Statins and COX-2 Inhibitors in the Prevention and Early Treatment of the Disease? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Respiratory Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18411276&form=6&db=m Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. therapeutic application,unassigned 1,0
1.14.99.1 Respiratory Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34364538&form=6&db=m Clinical evaluation and diagnosis of aspirin-exacerbated respiratory disease. causal interaction,unassigned 1,0
1.14.99.1 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494356&form=6&db=m Ibuprofen plus prostaglandin E1 in a septic porcine model of adult respiratory distress syndrome. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3881383&form=6&db=m Dexamethasone and indomethacin modify endotoxin-induced respiratory failure in pigs. causal interaction,unassigned 3,0
1.14.99.1 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8137655&form=6&db=m [The effect of cyclooxygenase and thromboxane synthetase inhibition on oxygen metabolism in canine acute respiratory failure] causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0
1.14.99.1 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10751353&form=6&db=m Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge: differential regulation in the various types of cells in the lung. causal interaction,unassigned 3,0
1.14.99.1 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11082503&form=6&db=m Effects of neuroactive substances on the morphine-induced respiratory depression; an in vitro study. ongoing research,unassigned 1,0
1.14.99.1 Respiratory Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33907758&form=6&db=m Cyclooxygenase inhibitor use is associated with increased COVID-19 severity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8998949&form=6&db=m Effect of antioxidants, anti-inflammatory drugs, and histamine antagonists on sparfloxacin-induced phototoxicity in mice. causal interaction,unassigned 3,0
1.14.99.1 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16584753&form=6&db=m Inhibition of cyclooxygenase-2 expression by zinc-chelator in retinal ischemia. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23791636&form=6&db=m Specific roles for Group V secretory PLA? in retinal iron-induced oxidative stress. Implications for age-related macular degeneration. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Retinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33806238&form=6&db=m Dynamics of Cyclooxygenase-1 Positive Microglia/Macrophage in the Retina of Pathological Model Mice as a Biomarker of the Retinal Inflammatory Diseases. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Retinal Dystrophies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1503245&form=6&db=m [The effect of cyclooxygenase inhibitors on the course of hereditary retinal dystrophy in RCS rats] therapeutic application,unassigned 2,0
1.14.99.1 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17923259&form=6&db=m Interaction between iNOS and COX-2 in hypoxia-induced retinal neovascularization in mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24458713&form=6&db=m Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. therapeutic application,unassigned 1,0
1.14.99.1 Retinal Neovascularization http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25472856&form=6&db=m Rofecoxib inhibits retinal neovascularization via down regulation of cyclooxygenase-2 and vascular endothelial growth factor expression. unassigned -
1.14.99.1 Retinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16782382&form=6&db=m Human cytomegalovirus induced cyclooxygenase-2 in human retinal pigment epithelial cells augments viral replication through a prostaglandin pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Retinitis Pigmentosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33059704&form=6&db=m Cyclooxygenase-1 mediates neuroinflammation and neurotoxicity in a mouse model of retinitis pigmentosa. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10704568&form=6&db=m Cox-2 expression in retinoblastoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11389063&form=6&db=m Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12960143&form=6&db=m Suppression of N-methyl-N-nitrosourea/testosterone-induced rat prostate cancer growth by celecoxib: effects on cyclooxygenase-2, cell cycle regulation, and apoptosis mechanism(s). causal interaction,diagnostic usage,ongoing research,unassigned 1,4,4,0
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15056456&form=6&db=m Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex. causal interaction,diagnostic usage,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16123787&form=6&db=m The effect of a selective cyclooxygenase-2 (COX-2) inhibitor on the proliferation rate of retinoblastoma cell lines. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16300681&form=6&db=m Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17011855&form=6&db=m The expression of cyclooxygenase 2 in retinoblastoma: primary enucleated eyes and enucleation after conservative treatment. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,4
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17876565&form=6&db=m Inhibitory effects of fenofibrate on apoptosis and cell proliferation in human endothelial cells in high glucose. diagnostic usage,unassigned 2,0
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19925514&form=6&db=m Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20373884&form=6&db=m Cyclooxygenase-2 expression in retinoblastoma: an immunohistochemical analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20530431&form=6&db=m Increased serum progesterone and estradiol correlate to increased COX-2 tissue expression in cervical intraepithelial neoplasia. diagnostic usage,unassigned 1,0
1.14.99.1 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20573388&form=6&db=m Expression of Ki-67 and COX-2 in patients with upper urinary tract urothelial carcinoma. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Retinopathy of Prematurity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7665397&form=6&db=m Peroxide-cyclooxygenase interactions in postasphyxial changes in retinal and choroidal hemodynamics. causal interaction,unassigned 3,0
1.14.99.1 Retinopathy of Prematurity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12601017&form=6&db=m COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Rett Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9071487&form=6&db=m Cyclooxygenase-2 expression during rat neocortical development and in Rett syndrome. ongoing research,unassigned 4,0
1.14.99.1 Rett Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12112730&form=6&db=m Neuropathology of Rett syndrome. causal interaction,unassigned 3,0
1.14.99.1 Rhabdoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820901&form=6&db=m Establishment and characterization of a new cell line, FRTK-1, derived from human malignant rhabdoid tumor of the kidney, with overexpression of epidermal growth factor receptor and cyclooxygenase-2. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Rhabdoid Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17143495&form=6&db=m Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1). causal interaction,ongoing research,therapeutic application,unassigned 1,1,3,0
1.14.99.1 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12024286&form=6&db=m Cyclooxygenase-2 expression in pediatric sarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679640&form=6&db=m Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15120641&form=6&db=m Fibronectin-induced COX-2 mediates MMP-2 expression and invasiveness of rhabdomyosarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15700850&form=6&db=m Cyclooxygenase-2 expression in uterine leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21874258&form=6&db=m Cyclooxygenase-2 expression is not associated with clinical outcome in synovial sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Rhabdomyosarcoma, Alveolar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8628978&form=6&db=m Clinical implications of selective cyclooxygenase-2 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8630641&form=6&db=m Safety of meloxicam: a global analysis of clinical trials. therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8870111&form=6&db=m Cyclooxygenase 1 and 2 in rheumatic disease: implications for nonsteroidal anti-inflammatory drug therapy. therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10422543&form=6&db=m COX-2: separating myth from reality. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10643694&form=6&db=m Basic biology and clinical application of specific cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10841068&form=6&db=m [Nonsteroidal anti-inflammatory agents in the management of rheumatic disorders] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11107811&form=6&db=m [Rheumatism therapy, from the economic viewpoint. COX-2 inhibitor as cost saving drug] therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192932&form=6&db=m The fight against rheumatism: from willow bark to COX-1 sparing drugs. therapeutic application,unassigned 2,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336565&form=6&db=m Intelligent use of NSAIDs--where do we stand? causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12022326&form=6&db=m High response rate in the phase I/II study of meloxicam in juvenile rheumatoid arthritis. therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12187755&form=6&db=m [Treatment of peptic ulcer related to rheumatic diseases] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12219613&form=6&db=m [Mobility and quality of life for arthrosis and rheumatism patients. Modern pain management with selective cox-2 inhibition] therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12705063&form=6&db=m [Epidemiological studies for evaluating the role of cyclooxygenase in chemoprevention of malignant tumors] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12854282&form=6&db=m [COX-2 inhibitors: a new treatment in rheumatic diseases] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12958786&form=6&db=m [Tolerable pain therapy in rheumatism saves long-term costs. Despite this most COX-2 candidates receive conventional NSAID therapy.] causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15013926&form=6&db=m Anti-inflammatory pharmacotherapy during pregnancy. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15086694&form=6&db=m Impact of selective cyclooxygenase-2 inhibitors on anti-ulcer medication and non-steroidal anti-inflammatory drug use in patients with rheumatic disease. therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546461&form=6&db=m Impact of selective cyclooxygenase-2 inhibitors on anti-ulcer medication and non-steroidal anti-inflammatory drug use in patients with rheumatic disease. therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17691996&form=6&db=m Efficacy of the newest COX-2 selective inhibitors in rheumatic disease. therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21829425&form=6&db=m Analgesics are not always the culprits: isolated gastric fundal varices as the cause of recurrent upper GI bleed in a patient with SLE, rheumatoid arthritis and polymyositis overlap syndrome. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22356222&form=6&db=m The management of chronic pain in important patient subgroups. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23389874&form=6&db=m The management of chronic pain in important patient subgroups. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24215502&form=6&db=m Assessment of nonsteroidal anti-inflammatory drug-induced cardiotoxicity. therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25222785&form=6&db=m Dipyrone & 2,5-dimethylcelecoxib suppress Th2-related chemokine production in monocyte. therapeutic application,unassigned 4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26360837&form=6&db=m Influence of genetic polymorphisms on the pharmacokinetics of celecoxib and its two main metabolites in healthy Chinese subjects. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26845207&form=6&db=m [Management of antirheumatic drugs in kidney failure]. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Rheumatic Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28056333&form=6&db=m [Recommendation for the prevention and treatment of non-steroidal anti-inflammatory drug-induced gastrointestinal ulcers and its complications]. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9416556&form=6&db=m Role of cyclooxygenase 1 and 2 in asthma and rhinitis. causal interaction,unassigned 4,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9431818&form=6&db=m Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps. diagnostic usage,ongoing research,therapeutic application,unassigned 2,1,1,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469640&form=6&db=m Effects of a specific cysteinyl leukotriene antagonist, pranlukast, on antigen-induced cysteinyl leukotriene-mediated rhinitis in guinea pigs. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9543076&form=6&db=m Expression of cyclo-oxygenase 1 and 2 proteins in upper respiratory mucosa. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11964666&form=6&db=m Aspirin-induced rhinitis and asthma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14561202&form=6&db=m Diagnosis, prevention and treatment of aspirin-induced asthma and rhinitis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15200266&form=6&db=m Expression of cyclooxygenase-2 in canine epithelial nasal tumors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15613671&form=6&db=m Aspirin sensitivity: implications for patients with coronary artery disease. therapeutic application,unassigned 4,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17030227&form=6&db=m Clinical and pathologic perspectives on aspirin sensitivity and asthma. therapeutic application,unassigned 3,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18627797&form=6&db=m Validation of guinea pig model of allergic rhinitis by oral and topical drugs. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19210906&form=6&db=m Aspirin sensitivity and desensitization for asthma and sinusitis. causal interaction,unassigned 1,0
1.14.99.1 Rhinitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663486&form=6&db=m Update on aspirin desensitization for chronic rhinosinusitis with polyps in aspirin-exacerbated respiratory disease (AERD). causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6715724&form=6&db=m Effect of flurbiprofen, a cyclooxygenase inhibiting drug, on induced allergic rhinitis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9469640&form=6&db=m Effects of a specific cysteinyl leukotriene antagonist, pranlukast, on antigen-induced cysteinyl leukotriene-mediated rhinitis in guinea pigs. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9543076&form=6&db=m Expression of cyclo-oxygenase 1 and 2 proteins in upper respiratory mucosa. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11407311&form=6&db=m Decreased serum IgE level, decreased IFN-gamma and IL-5 but increased IL-10 production, and suppressed cyclooxygenase 2 mRNA expression in patients with perennial allergic rhinitis after treatment with a new mixed formula of Chinese herbs. causal interaction,unassigned 3,0
1.14.99.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895602&form=6&db=m The DP receptor, allergic inflammation and asthma. unassigned -
1.14.99.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17016062&form=6&db=m New evidence of H1-receptor independent COX-2 inhibition by fexofenadine HCl in vitro. therapeutic application,unassigned 4,0
1.14.99.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28400178&form=6&db=m Polymorphisms in chronic rhinosinusitis with nasal polyps - a systematic review. causal interaction,unassigned 4,0
1.14.99.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30953868&form=6&db=m A novel concept of immunological and allergy interactions in autism spectrum disorders: Molecular, anti-inflammatory effect of osthole. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Rhinitis, Allergic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32182661&form=6&db=m The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Rhinitis, Allergic, Seasonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2897986&form=6&db=m Hay fever treatment with combined antihistamine and cyclooxygenase-inhibiting drugs. therapeutic application,unassigned 1,0
1.14.99.1 Rhinitis, Allergic, Seasonal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15587760&form=6&db=m Combination treatment using the COX-2 inhibitor meloxicam and an anti-allergic in pollinosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Riboflavin Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3921989&form=6&db=m Effects of riboflavin deficiency upon prostaglandin biosynthesis in rat kidney. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Rickettsia Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16481516&form=6&db=m Potential roles for regulatory oxygenases in rickettsial pathogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Rickettsia Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16926398&form=6&db=m Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Rickettsia Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22522044&form=6&db=m Regulation of inducible heme oxygenase and cyclooxygenase isozymes in a mouse model of spotted fever group rickettsiosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Rocky Mountain Spotted Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19438652&form=6&db=m Rickettsia rickettsii infection of human pulmonary microvascular endothelial cells: modulation of cyclooxygenase-2 expression. ongoing research,unassigned 4,0
1.14.99.1 Rocky Mountain Spotted Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20385756&form=6&db=m Rickettsia rickettsii infection of human macrovascular and microvascular endothelial cells reveals activation of both common and cell type-specific host response mechanisms. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Root Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16454238&form=6&db=m Celebrex offers a small protection from root resorption associated with orthodontic movement. therapeutic application,unassigned 3,0
1.14.99.1 Root Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18713152&form=6&db=m Histological analysis of orthodontic root resorption in rats treated with the cyclooxygenase-2 (COX-2) inhibitor celecoxib. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Root Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21481035&form=6&db=m Primary teeth show less protecting factors against root resorption. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Root Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28444165&form=6&db=m Proinflammatory mediators related to orthodontically induced periapical root resorption in rat mandibular molars. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,2,1
1.14.99.1 Root Resorption http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31697637&form=6&db=m Effects of Photobiomodulation and Ultrasound Applications on Orthodontically Induced Inflammatory Root Resorption; Transcriptional Alterations in OPG, RANKL, Cox-2: An Experimental Study in Rats. ongoing research,unassigned 2,0
1.14.99.1 Rotavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15331705&form=6&db=m Inhibition of cyclooxygenase activity reduces rotavirus infection at a postbinding step. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Rotavirus Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27382365&form=6&db=m PPAR? Agonists as an Anti-Inflammatory Treatment Inhibiting Rotavirus Infection of Small Intestinal Villi. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12654832&form=6&db=m Salmonella infection induces a hypersecretory phenotype in human intestinal xenografts by inducing cyclooxygenase 2. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Salmonella Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19543553&form=6&db=m Cyclooxygenase-2 Inhibition Enhances Activation of T Helper Type 1 Responses During Salmonella Infection. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Salter-Harris Fractures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16619262&form=6&db=m Roles of COX-2 and iNOS in the bony repair of the injured growth plate cartilage. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,2
1.14.99.1 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6145948&form=6&db=m Prostaglandin synthetase inhibition in hypercalcaemia with sarcoidosis. causal interaction,unassigned 2,0
1.14.99.1 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14511257&form=6&db=m Reduced expression of cyclooxygenase (COX) in idiopathic pulmonary fibrosis and sarcoidosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16840740&form=6&db=m Functional prostaglandin-endoperoxide synthase 2 polymorphism predicts poor outcome in sarcoidosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18514098&form=6&db=m Association of the 3050G>C polymorphism in the cyclooxygenase 2 gene with systemic sarcoidosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19042116&form=6&db=m Cyclooxygenase-2 polymorphisms confer susceptibility to sarcoidosis but are not related to prognosis. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21416732&form=6&db=m [Cyclooxygenase-2 polymorphisms and bronchoalveolar lavage cellularity of sarcoidosis]. causal interaction,unassigned 4,0
1.14.99.1 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24768588&form=6&db=m Gene expression profiles in granuloma tissue reveal novel diagnostic markers in sarcoidosis. ongoing research,unassigned 2,0
1.14.99.1 Sarcoidosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27188849&form=6&db=m Altered Cyclooxygenase-2 Expression in Pulmonary Sarcoidosis is not Related to Clinical Classifications. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Sarcoidosis, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2788378&form=6&db=m Interleukin 1 production by alveolar macrophages is decreased in smokers. therapeutic application,unassigned 1,0
1.14.99.1 Sarcoidosis, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6388445&form=6&db=m Prostaglandins and thromboxanes in the bronchoalveolar lavage fluid: possible immunoregulation in sarcoidosis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Sarcoidosis, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6573247&form=6&db=m Production of cyclooxygenase products by alveolar macrophages in pulmonary sarcoidosis. causal interaction,unassigned 3,0
1.14.99.1 Sarcoidosis, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27188849&form=6&db=m Altered Cyclooxygenase-2 Expression in Pulmonary Sarcoidosis is not Related to Clinical Classifications. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6768608&form=6&db=m Prevention of drug-induced upset to energy production in the S180 sarcoma by inhibition of prostaglandin synthetase [proceedings] therapeutic application,unassigned 2,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605037&form=6&db=m Cyclooxygenase-2 expression in malignant mesenchymal tumors and related uterine lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12024286&form=6&db=m Cyclooxygenase-2 expression in pediatric sarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12124326&form=6&db=m Cyclooxygenase-2 inhibitor treatment enhances photodynamic therapy-mediated tumor response. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12377342&form=6&db=m In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerations. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12499278&form=6&db=m Simultaneous reduction in cancer pain, bone destruction, and tumor growth by selective inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679640&form=6&db=m Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949405&form=6&db=m An immunohistochemical study of cyclooxygenase-2 expression in various feline neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12972806&form=6&db=m Effect of combined cyclooxygenase-2 and matrix metalloproteinase inhibition on human sarcoma xenografts. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14629333&form=6&db=m COX-2 expression in striated muscle under physiological conditions. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14981912&form=6&db=m A selective cyclooxygenase-2 inhibitor, NS-398, inhibits cell growth by cell cycle arrest in a human malignant fibrous histiocytoma cell line. ongoing research,unassigned 3,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15218294&form=6&db=m Cyclooxygenase-2 expression in chondrosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15604909&form=6&db=m Advances that are changing the diagnosis and treatment of malignant bone tumors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15872381&form=6&db=m Assessment of cyclooxygenase-2 expression in canine hemangiosarcoma, histiocytic sarcoma, and mast cell tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,3
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080510&form=6&db=m Cyclooxygenase-2 expression in human soft-tissue sarcomas is related to epithelial differentation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17094458&form=6&db=m Establishment and characterization of a new cell line, FPS-1, derived from human undifferentiated pleomorphic sarcoma, overexpressing epidermal growth factor receptor and cyclooxygenase-2. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18411276&form=6&db=m Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. therapeutic application,unassigned 1,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20652953&form=6&db=m The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21412163&form=6&db=m Cyclooxygenase-2 Is an Independent Predictor of Poor Prognosis in Uterine Leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21765608&form=6&db=m Prebiotic treatment reduced preneoplastic lesions through the downregulation of toll like receptor 4 in a chemo-induced carcinogenic model. ongoing research,unassigned 3,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21874258&form=6&db=m Cyclooxygenase-2 expression is not associated with clinical outcome in synovial sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23161574&form=6&db=m The pharmacologic inhibition of the xc- antioxidant system improves the antitumor efficacy of COX inhibitors in the in vivo model of 3-MCA tumorigenesis. therapeutic application,unassigned 4,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23645742&form=6&db=m Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-?B and matrix metalloproteinase-2/-9 signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 1,1,1,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25214858&form=6&db=m Expression of HuR and Cyclooxygenase-2 in Nodular Fasciitis and Low-Grade Sarcoma: An Immunohistochemical Study. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,4,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30502795&form=6&db=m Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30930224&form=6&db=m Inhibition of PSMD4 blocks the tumorigenesis of hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Sarcoma 180 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9426072&form=6&db=m Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,3,3
1.14.99.1 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8357977&form=6&db=m Drug inhibition and cellular regulation of prostaglandin G/H synthase isoenzyme 2. unassigned -
1.14.99.1 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10177217&form=6&db=m Simulated lung transfection by nebulization of liposome cDNA complexes using a cascade impactor seeded with 2-CFSME0-cells. ongoing research,unassigned 1,0
1.14.99.1 Sarcoma, Avian http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15892618&form=6&db=m Molecularly targeted therapy for gastrointestinal cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Sarcoma, Endometrial Stromal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605037&form=6&db=m Cyclooxygenase-2 expression in malignant mesenchymal tumors and related uterine lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Sarcoma, Endometrial Stromal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21412163&form=6&db=m Cyclooxygenase-2 Is an Independent Predictor of Poor Prognosis in Uterine Leiomyosarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12024286&form=6&db=m Cyclooxygenase-2 expression in pediatric sarcomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679640&form=6&db=m Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18705402&form=6&db=m Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19524730&form=6&db=m Cyclooxygenase 2 mediates the antiangiogenic effect of rapamycin in Ewing sarcoma. unassigned -
1.14.99.1 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21238650&form=6&db=m Selective inhibition of cyclooxygenase-2 suppresses metastatic disease without affecting primary tumor growth in a murine model of Ewing sarcoma. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22703797&form=6&db=m Celecoxib inhibits invasion and metastasis via a cyclooxygenase 2-independent mechanism in an in vitro model of Ewing sarcoma. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17467980&form=6&db=m Evidence of COX-1 and COX-2 expression in Kaposi's sarcoma tissues. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868457&form=6&db=m Kaposi's sarcoma associated herpesvirus G-protein coupled receptor activation of cyclooxygenase-2 in vascular endothelial cells. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20169190&form=6&db=m Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20943963&form=6&db=m NFAT AND CREB REGULATE KAPOSI'S SARCOMA ASSOCIATED HERPES VIRUS (KSHV) INDUCED CYCLOOXYGENASE-2 (COX-2). causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27531260&form=6&db=m [Let-7 miRNA silencing promotes Kaposi's sarcoma-associated herpesvirus lytic replication via activating mitogen-activated protein kinase kinase kinase kinase 4 and its downstream factors]. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Sarcoma, Kaposi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33057440&form=6&db=m KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi's sarcoma. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Sarcoma, Synovial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16080510&form=6&db=m Cyclooxygenase-2 expression in human soft-tissue sarcomas is related to epithelial differentation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Sarcoma, Synovial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21874258&form=6&db=m Cyclooxygenase-2 expression is not associated with clinical outcome in synovial sarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Sarcoma, Synovial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27313839&form=6&db=m Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Sarcopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21160058&form=6&db=m Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Sarcopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23490068&form=6&db=m Prostaglandin E2 induces transcription of skeletal muscle mass regulators interleukin-6 and muscle RING finger-1 in humans. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954496&form=6&db=m Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25434139&form=6&db=m [Relationship between multi-gene proteins in colorectal carcinoma complicated with chronic schistosomiasis: an immunohistochemical study by using tissue microarray techniques]. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Schistosomiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25507737&form=6&db=m [Relationship between multi-gene proteins in colorectal carcinoma complicated with chronic schistosomiasis: an immunohistochemical study by using tis- sue microarray techniques]. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Scleritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15953441&form=6&db=m Celecoxib, a selective inhibitor of cyclooxygenase 2 for therapy of diffuse anterior scleritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Scleritis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26308394&form=6&db=m Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis. therapeutic application,unassigned 4,0
1.14.99.1 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21979415&form=6&db=m Serum concentrations of cyclooxygenase-2 in patients with systemic sclerosis: association with lower frequency of pulmonary fibrosis. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24473763&form=6&db=m Immunohistochemical and morphometric evaluation of COX 1 and COX-2 in the remodeled lung in idiopathic pulmonary fibrosis and systemic sclerosis. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,2,0
1.14.99.1 Scleroderma, Systemic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26744410&form=6&db=m Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Scoliosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064322&form=6&db=m Low expression of microRNA-143 is related to degenerative scoliosis possibly by regulation of cyclooxygenase-2 expression. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Scrapie http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17524497&form=6&db=m Increased expression and localization of cyclooxygenase-2 in astrocytes of scrapie-infected mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1904682&form=6&db=m Mechanisms of asphyxial brain damage, and possible pharmacologic interventions, in the fetus. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2127458&form=6&db=m Lipoxygenase products of polyunsaturated fatty acid metabolism in the central nervous system: biosynthesis and putative functions. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2510202&form=6&db=m Neuroendocrine involvements of the prostaglandin autacoids. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2836558&form=6&db=m Characterization of seizure-induced cysteinyl-leukotriene formation in brain tissue of convulsion-prone gerbils. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2921292&form=6&db=m Cerebral superoxide anion generation during seizures in newborn pigs. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2936171&form=6&db=m Formation and functions of prostaglandins in the central nervous system in rodents. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3109689&form=6&db=m Evidence for increased activity of mouse brain fatty acid cyclooxygenase following drug-induced convulsions. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3927864&form=6&db=m Differential effect of prostaglandin synthetase inhibitor pretreatment on pentylenetetrazol-induced seizures in rat. ongoing research,unassigned 3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6433367&form=6&db=m Effect of prostaglandin synthetase inhibitors on experimentally induced convulsions in rats. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6435184&form=6&db=m Anticonvulsive effects of endogenous prostaglandins formed in brain of spontaneously convulsing gerbils. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7756602&form=6&db=m Expression of cyclo-oxygenase 2 in rat brain following kainate treatment. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8069664&form=6&db=m The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8798751&form=6&db=m Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. diagnostic usage,unassigned 1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9168834&form=6&db=m Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9202336&form=6&db=m Lesioning of deep prepiriform cortex protects against ischemic neuronal necrosis by attenuating extracellular glutamate concentrations. causal interaction,unassigned 3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9367271&form=6&db=m Inferior collicular seizure generalization produces site-selective cortical induction of cyclooxygenase 2 (COX-2). causal interaction,unassigned 2,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9757041&form=6&db=m Behavioral changes and expression of heat shock protein hsp-70 mRNA, brain-derived neurotrophic factor mRNA, and cyclooxygenase-2 mRNA in rat brain following seizures induced by systemic administration of kainic acid. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10528118&form=6&db=m Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11168565&form=6&db=m The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus. causal interaction,ongoing research,unassigned 2,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11251211&form=6&db=m Cyclooxygenase-2 expression in the hippocampus of genetically epilepsy susceptible El mice was increased after seizure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11393589&form=6&db=m Nimesulide aggravates kainic acid-induced seizures in the rat. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12065615&form=6&db=m In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E(2) extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms. causal interaction,unassigned 3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12443977&form=6&db=m The long-term high-frequency repetitive transcranial magnetic stimulation does not induce mRNA expression of inflammatory mediators in the rat central nervous system. ongoing research,unassigned 1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12731453&form=6&db=m Anticonvulsant action of celecoxib (alone and in combination with sub-threshold dose of phenytoin) in electroshock induced convulsion. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14518562&form=6&db=m Inducible brain COX-2 facilitates the recurrence of hippocampal seizures in mouse rapid kindling. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14643773&form=6&db=m The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice: involvement of proinflammatory factors: nitric oxide and prostaglandins. therapeutic application,unassigned 3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15266962&form=6&db=m Differential effect of cyclooxygenase-2 preferring [correction of prefering] inhibitors on electrically- and chemically-induced seizures in mice. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15979590&form=6&db=m Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139898&form=6&db=m Involvement of prostaglandins in an animal model of Shigella-related seizures. therapeutic application,unassigned 4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16263251&form=6&db=m Assessment of the effects of the cyclooxygenase-2 inhibitor rofecoxib on visuospatial learning and hippocampal cell death following kainate-induced seizures in the rat. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16436115&form=6&db=m Cyclooxygenase-2 expression and effect of celecoxib in flurothyl-induced neonatal seizure. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522321&form=6&db=m Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice. causal interaction,unassigned 4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16569634&form=6&db=m Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: dual phase regulation and differential involvement of COX-1 and COX-2. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16629370&form=6&db=m Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677768&form=6&db=m Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806953&form=6&db=m Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16837093&form=6&db=m Prostaglandin E(2) produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16844276&form=6&db=m Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16870400&form=6&db=m The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: Possible role of cyclooxygenase-2 induction. therapeutic application,unassigned 4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17139446&form=6&db=m Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice. therapeutic application,unassigned 4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17369894&form=6&db=m Effect of indomethacin on cerebral blood flow and development of oxygen convulsions. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612048&form=6&db=m Role of COX-2 in inflammatory and degenerative brain diseases. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17629358&form=6&db=m Roles of prostaglandin synthesis in excitotoxic brain diseases. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17827730&form=6&db=m Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. unassigned -
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18054463&form=6&db=m Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor increases pentylenetetrazol seizure threshold in mice: possible involvement of adenosinergic mechanism. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18094072&form=6&db=m Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18178179&form=6&db=m Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18255268&form=6&db=m Cyclooxygenase-2/PGE(2) pathway facilitates pentylenetetrazol-induced seizures. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18355636&form=6&db=m Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18834901&form=6&db=m NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. causal interaction,unassigned 4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19186029&form=6&db=m Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19371577&form=6&db=m Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19523994&form=6&db=m Stage- and region-specific cyclooxygenase expression and effects of a selective COX-1 inhibitor in the mouse amygdala kindling model. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19786037&form=6&db=m COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19890496&form=6&db=m Signaling to P-glycoprotein-A new therapeutic target to treat drug-resistant epilepsy? causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20600289&form=6&db=m Soman increases neuronal COX-2 levels: Possible link between seizures and protracted neuronal damage. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20609063&form=6&db=m Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice. therapeutic application,unassigned 3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20643531&form=6&db=m Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20655707&form=6&db=m Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21158027&form=6&db=m [Time course of COX-2 expression in hippocampus of the seizure rats]. unassigned -
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21219314&form=6&db=m Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21856425&form=6&db=m Neuromodulatory role of endogenous interleukin-1? in acute seizures: Possible contribution of cyclooxygenase-2. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22016518&form=6&db=m Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22091840&form=6&db=m Prostaglandin E(2) potentiates methylmalonate-induced seizures. ongoing research,unassigned 2,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23207777&form=6&db=m Involvement of the arachidonic acid cascade in the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal. therapeutic application,unassigned 1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23211629&form=6&db=m Resveratrol pre-treatment reduces early inflammatory responses induced by status epilepticus via mTOR signaling. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401547&form=6&db=m Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24005111&form=6&db=m Seizure susceptibility in immature brain due to lack of COX-2-induced PGF2? causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,2
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24446952&form=6&db=m Cyclooxygenase-2 in epilepsy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25453777&form=6&db=m Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. unassigned -
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25600211&form=6&db=m Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25660085&form=6&db=m Anticonvulsant activity of the cyclooxygenase-2 (COX-2) inhibitor etoricoxib in pentylenetetrazole-kindled rats is associated with memory impairment. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25701797&form=6&db=m Antiepileptogenic effects of the selective COX-2 inhibitor etoricoxib, on the development of spontaneous absence seizures in WAG/Rij rats. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26045880&form=6&db=m Emodin plays an interventional role in epileptic rats via multidrug resistance gene 1 (MDR1). causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26961169&form=6&db=m Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae. therapeutic application,unassigned 1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27895618&form=6&db=m Cyclooxygenase-1 as a Potential Therapeutic Target for Seizure Suppression: Evidences from Zebrafish Pentylenetetrazole-Seizure Model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28017780&form=6&db=m Acute effects of aceclofenac, COX-2 inhibitor, on penicillin-induced epileptiform activity. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28097203&form=6&db=m Staged anticonvulsant screening for chronic epilepsy. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28210513&form=6&db=m Seizure following the Use of the COX-2 Inhibitor Etoricoxib. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212985&form=6&db=m Nonsteroidal anti-inflammatory drugs in clinical and experimental epilepsy. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28352122&form=6&db=m Long-term electrical stimulation at ear and electro-acupuncture at ST36-ST37 attenuated COX-2 in the CA1 of hippocampus in kainic acid-induced epileptic seizure rats. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28583427&form=6&db=m Cyclooxygenase-2 inhibitors differentially attenuate pentylenetetrazol-induced seizures and increase of pro- and anti-inflammatory cytokine levels in the cerebral cortex and hippocampus of mice. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29337236&form=6&db=m Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,1
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29655084&form=6&db=m Discovery of novel Methylsulfonyl phenyl derivatives as potent human Cyclooxygenase-2 inhibitors with effective anticonvulsant action: Design, synthesis, in-silico, in-vitro and in-vivo evaluation. therapeutic application,unassigned 1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29763644&form=6&db=m Immunomodulatory effect of Celecoxib on HMGB1/TLR4 pathway in a recurrent seizures model in immature rats. causal interaction,unassigned 2,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30229386&form=6&db=m Carvacrol mitigates proconvulsive effects of lipopolysaccharide, possibly through the hippocampal cyclooxygenase-2 inhibition. ongoing research,unassigned 4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30529453&form=6&db=m Temporal profile of serum mitochondrial DNA (mtDNA) in patients with aneurysmal subarachnoid hemorrhage (aSAH). therapeutic application,unassigned 1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31421074&form=6&db=m Inflammation and reactive oxygen species as disease modifiers in epilepsy. therapeutic application,unassigned 3,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31666079&form=6&db=m Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32913950&form=6&db=m COX-2/PGE2 axis regulates hippocampal BDNF/TrkB signaling via EP2 receptor after prolonged seizures. therapeutic application,unassigned 1,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32929133&form=6&db=m In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia. unassigned -
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34019198&form=6&db=m Gamma-Decanolactone Alters the Expression of GluN2B, A1 Receptors, and COX-2 and Reduces DNA Damage in the PTZ-Induced Seizure Model After Subchronic Treatment in Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34037084&form=6&db=m Treatment-resistant bipolar depression: concepts and challenges for novel interventions. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1597045&form=6&db=m Phospholipids and their inhibitors: a critical evaluation of their role in the treatment of sepsis. unassigned -
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1952438&form=6&db=m Prostacyclin and thromboxane A2 formation is increased in human sepsis syndrome. Effects of cyclooxygenase inhibition. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2272983&form=6&db=m Failure of therapy with 2,3-dihydroxybenzoic acid to modify the course of sepsis-induced lung injury. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2647225&form=6&db=m Role of tumor necrosis factor in sepsis and acute lung injury. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3109759&form=6&db=m Inhibition of eicosanoid production by BW755C does not attenuate sepsis-induced alterations in glucose kinetics. ongoing research,unassigned 3,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3120143&form=6&db=m Effect of cyclooxygenase and lipoxygenase products on pulmonary function in group B streptococcal sepsis. ongoing research,unassigned 1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3132720&form=6&db=m Group B streptococcal (GBSS) newborn septic shock model: the role of prostaglandins. diagnostic usage,therapeutic application,unassigned 3,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3530674&form=6&db=m Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3542276&form=6&db=m Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6221585&form=6&db=m Comparison of thromboxane inhibitors to cyclooxygenase inhibitors on survival in a newborn rat model for group B streptococcal sepsis. therapeutic application,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6509729&form=6&db=m Methylprednisolone plus ibuprofen increases mortality in septic rats. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6683924&form=6&db=m Thromboxane synthetase inhibitors in septic shock. ongoing research,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6756668&form=6&db=m The effects of a prostaglandin synthetase inhibitor, ibuprofen, on the cardiopulmonary response to endotoxin in sheep. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7743370&form=6&db=m Differential microvascular response to cyclooxygenase blockade in the rat small intestine during acute bacteremia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7981779&form=6&db=m Regional blood flow distribution in endotoxin-treated dogs: modification by ibuprofen. ongoing research,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8093999&form=6&db=m Pharmacologic reduction in tumor necrosis factor activity of pulmonary alveolar macrophages. therapeutic application,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8361173&form=6&db=m Blockade of prostaglandin products augments macrophage and neutrophil tumor necrosis factor synthesis in burn injury. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8493358&form=6&db=m Cecal ligation and puncture is associated with pulmonary injury in the rat: role of cyclooxygenase pathway products. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8507112&form=6&db=m Tumor necrosis factor-induced mortality is reversed with cyclooxygenase inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8777837&form=6&db=m Differential regulation of cyclo-oxygenase-1 and cyclo-oxygenase-2 gene expression by lipopolysaccharide treatment in vivo in the rat. causal interaction,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8797133&form=6&db=m Cyclooxygenase inhibition and vascular reactivity in a rat model of hyperdynamic sepsis. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8832221&form=6&db=m Evidence for tumor necrosis factor alpha as a mediator of the toxicity of a cyclooxygenase inhibitor in Gram-negative sepsis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8835089&form=6&db=m Cardiopulmonary effects of tumor necrosis factor-alpha in the piglet: influence of cyclooxygenase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9070471&form=6&db=m The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679714&form=6&db=m Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9715175&form=6&db=m Cyclooxygenase-2 inhibitor NS-398 improves survival and restores leukocyte counts in burn infection. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10211684&form=6&db=m Endotoxin induction of nitric oxide synthase and cyclooxygenase-2 in equine alveolar macrophages. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336884&form=6&db=m Isoprostanes and PGE2 production in human isolated pulmonary artery smooth muscle cells: concomitant and differential release. causal interaction,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10702448&form=6&db=m Cyclooxygenase inhibitors attenuate bradykinin-induced vasoconstriction in septic isolated rat lungs. causal interaction,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10766854&form=6&db=m mRNA and protein stability regulate the differential expression of pro- and anti-inflammatory genes in endotoxin-tolerant THP-1 cells. unassigned -
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11770048&form=6&db=m Cyclooxygenase-2-mediated regulation of Kupffer cell interleukin-6 production following trauma-hemorrhage and subsequent sepsis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12189304&form=6&db=m Cyclooxygenase-2 and nuclear factor-kappaB in myocardium of end stage human heart failure. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12770513&form=6&db=m Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14966110&form=6&db=m Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1. causal interaction,unassigned 1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15142421&form=6&db=m Inhibition of cyclooxygenase-2 by NS-398 following hemorrhage and subsequent sepsis: no beneficial effects in either gender. ongoing research,unassigned 1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15232498&form=6&db=m Pentoxyphilline as a cyclooxygenase (cox-2) inhibitor in experimental sepsis. therapeutic application,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15734490&form=6&db=m Kupffer cell ablation attenuates cyclooxygenase-2 expression after trauma and sepsis. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15770588&form=6&db=m Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. causal interaction,unassigned 2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16153419&form=6&db=m Ketamine attenuates liver injury attributed to endotoxemia: role of cyclooxygenase-2. causal interaction,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16525353&form=6&db=m Influence of cyclooxygenase inhibitors on gut immune cell distribution and apoptosis rate in experimental sepsis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16557423&form=6&db=m Imaging cyclooxygenase-2 (Cox-2) gene expression in living animals with a luciferase knock-in reporter gene. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17634395&form=6&db=m Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18339158&form=6&db=m Bupivacaine inhibits COX-2 expression, PGE2, and cytokine production in endotoxin-activated macrophages. causal interaction,unassigned 3,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19527795&form=6&db=m Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957141&form=6&db=m Hydrogen sulfide upregulates cyclooxygenase-2 and prostaglandin E metabolite in sepsis-evoked acute lung injury via transient receptor potential vanilloid type 1 channel activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21967897&form=6&db=m Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22356547&form=6&db=m Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22665954&form=6&db=m Cyclooxygenase inhibition in sepsis: is there life after death? causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23463959&form=6&db=m Serum adipocyte fatty acid-binding protein in the critically ill. unassigned -
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23646479&form=6&db=m [Effects of polydatin on ALT, AST, TNF-alpha, and COX-2 in sepsis model mice]. ongoing research,unassigned 1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24789991&form=6&db=m Role of prostaglandins in determining the increased cardiac sympathetic nerve activity in ovine sepsis. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26308761&form=6&db=m Preclinical Studies Suggest Complex Nutraceutical Strategies May Have Potential for Preventing and Managing Sepsis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26645911&form=6&db=m Characterization of changes in plasma and tissue oxylipin levels in LPS and CLP induced murine sepsis. unassigned -
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27887602&form=6&db=m Combination of aspirin with essential fatty acids is superior to aspirin alone to prevent or ameliorate sepsis or ARDS. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28024294&form=6&db=m Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic rats. causal interaction,unassigned 4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28533769&form=6&db=m Celecoxib Enhances the Efficacy of Low-Dose Antibiotic Treatment against Polymicrobial Sepsis in Mice and Clinical Isolates of ESKAPE Pathogens. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29243040&form=6&db=m Protective effect of acacetin on sepsis-induced acute lung injury via its anti-inflammatory and antioxidative activity. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29704392&form=6&db=m The Nephroprotective Effect of MS-275 on Lipopolysaccharide (LPS)-Induced Acute Kidney Injury by Inhibiting Reactive Oxygen Species (ROS)-Oxidative Stress and Endoplasmic Reticulum Stress. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29782861&form=6&db=m Foenumoside B isolated from Lysimachia foenum-graecum extract suppresses LPS-induced inflammatory response via NF-?B/AP-1 inactivation in murine macrophages and in endotoxin-induced shock model. ongoing research,unassigned 2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30326393&form=6&db=m ?-glutamylcysteine exhibits anti-inflammatory effects by increasing cellular glutathione level. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31070531&form=6&db=m Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31307465&form=6&db=m Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32454767&form=6&db=m Anti-inflammatory Effects of Deuterium-Depleted Water Plus Rosa Damascena Mill. Essential Oil Via Cyclooxygenase-2 Pathway in Rats. unassigned -
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33038329&form=6&db=m 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole ameliorates long-lasting depression- and anxiogenic-like behaviors and cognitive impairment in post-septic mice: Involvement of neuroimmune and oxidative hallmarks. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33565395&form=6&db=m [Screening and identification of potential targets of carthamin against sepsis]. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33946773&form=6&db=m Bone Marrow Mesenchymal Stromal Cells on Silk Fibroin Scaffolds to Attenuate Polymicrobial Sepsis Induced by Cecal Ligation and Puncture. ongoing research,unassigned 3,0
1.14.99.1 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34483900&form=6&db=m A Systematic Study of the Mechanism of Acacetin Against Sepsis Based on Network Pharmacology and Experimental Validation. therapeutic application,unassigned 1,0
1.14.99.1 Sepsis-Associated Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31622656&form=6&db=m Experimental sepsis-associated encephalopathy is accompanied by altered cerebral blood perfusion and water diffusion and related to changes in cyclooxygenase-2 expression and glial cell morphology but not to blood-brain barrier breakdown. unassigned -
1.14.99.1 Sertoli Cell-Only Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20188355&form=6&db=m Cyclooxygenase-2 in testes of infertile men: evidence for the induction of prostaglandin synthesis by interleukin-1beta. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Serum Sickness http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3222274&form=6&db=m Glomerular eicosanoid production in acute serum sickness nephritis. therapeutic application,unassigned 1,0
1.14.99.1 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16962108&form=6&db=m A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis xenografts via antiangiogenic activity in severe combined immunodeficiency mice. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Severe Combined Immunodeficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23608225&form=6&db=m miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF). causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Sexually Transmitted Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11142931&form=6&db=m Rectal stricture associated with the long-term use of ibuprofen suppositories. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1326683&form=6&db=m Ibuprofen intervention in canine septic shock: reduction of pathophysiology without decreased cytokines. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1920504&form=6&db=m L-alpha-phosphatidylcholine-induced stimulation of PGI2 production in canine gallbladders following hypovolemic shock and Escherichia coli sepsis. unassigned -
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2494673&form=6&db=m Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3016060&form=6&db=m Role of thromboxane, prostaglandins and leukotrienes in endotoxic and septic shock. causal interaction,unassigned 4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3150270&form=6&db=m Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3542276&form=6&db=m Effect of methylprednisolone, indomethacin, and diethylcarbamazine on survival rate following trauma and sepsis in rats. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3797625&form=6&db=m Inhibition of vasoactive substances in experimental endotoxin shock. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6339712&form=6&db=m Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6410700&form=6&db=m Prostaglandin synthetase inhibitors in endotoxin or septic shock--a review. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6467521&form=6&db=m Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor. therapeutic application,unassigned 4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6585848&form=6&db=m Protection of myocardial function during endotoxin shock by ibuprofen. causal interaction,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7107893&form=6&db=m Ibuprofen in canine endotoxin shock. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7855444&form=6&db=m Effects of two different inhibitors of the arachidonic acid metabolism on platelet sequestration in endotoxic shock. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8335578&form=6&db=m TNF-alpha and cyclooxygenase metabolites do not modulate C. albicans septic shock with disseminated candidiasis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8379340&form=6&db=m Circulatory responses to endothelin-1 and nitric oxide with special reference to endotoxin shock and nitric oxide inhalation. causal interaction,unassigned 3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8925198&form=6&db=m Indomethacin and thromboxane A2/prostaglandin H2 antagonist SQ29,548 impair in vitro contractions of aortic rings of ex vivo-treated lipopolysaccharide rats. therapeutic application,unassigned 3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9187606&form=6&db=m The endothelin receptor antagonist, bosentan, in combination with the cyclooxygenase inhibitor, diclofenac, counteracts pulmonary hypertension in porcine endotoxin shock. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9459080&form=6&db=m Selective inhibition of cyclooxygenase-2 by NS-398 in endotoxin shock rats in vivo. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10402437&form=6&db=m Induction of nitric oxide synthase and dual effects of nitric oxide and cyclooxygenase products in regulation of arterial contraction in human septic shock. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10480288&form=6&db=m Induction of cytosolic phospholipase A2 and prostaglandin H2 synthase-2 by lipopolysaccharide in human polymorphonuclear leukocytes. causal interaction,unassigned 1,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10841043&form=6&db=m Vitamin E in relation to lipid peroxidation in experimental septic shock. ongoing research,unassigned 2,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12177064&form=6&db=m Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12872987&form=6&db=m Modulation of cyclooxygenase-2 expression by phosphatidylcholine specific phospholipase C and D in macrophages stimulated with lipopolysaccharide. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15329582&form=6&db=m Human septic myopathy: induction of cyclooxygenase, heme oxygenase and activation of the ubiquitin proteolytic pathway. ongoing research,unassigned 3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17637181&form=6&db=m Eugenosedin-A amelioration of lipopolysaccharide-induced up-regulation of p38 MAPK, inducible nitric oxide synthase and cyclooxygenase-2. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18496243&form=6&db=m Cyclooxygenase 2 pathway and its therapeutic inhibition in superantigen-induced toxic shock. therapeutic application,unassigned 4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571461&form=6&db=m Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-kappaB pathways. ongoing research,unassigned 3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18606903&form=6&db=m Activation of the PGI(2)/IP system contributes to the development of circulatory failure in a rat model of endotoxic shock. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21701768&form=6&db=m A glycoprotein from Porphyra yezoensis produces anti-inflammatory effects in liposaccharide-stimulated macrophages via the TLR4 signaling pathway. causal interaction,unassigned 1,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22637723&form=6&db=m Nodakenin Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Macrophage Cells by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 and Nuclear Factor-?B Pathways and Protects Mice from Lethal Endotoxin Shock. ongoing research,unassigned 4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684565&form=6&db=m Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24150174&form=6&db=m Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. unassigned -
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25243423&form=6&db=m Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26931732&form=6&db=m ?-Solanine Isolated from Solanum tuberosum L. cv Jayoung Abrogates LPS-Induced Inflammatory Responses via NF-?B Inactivation in RAW 264.7 Macrophages and Endotoxin-Induced Shock Model in Mice. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28363868&form=6&db=m Neoagarooligosaccharides prevent septic shock by modulating A20-and cyclooxygenase-2-mediated interleukin-10 secretion in a septic-shock mouse model. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30102640&form=6&db=m Myocardial Redox Hormesis Protects the Heart of Female Mice in Sepsis. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31278427&form=6&db=m Inducible cardiac-specific overexpression of cyclooxygenase-2 (COX-2) confers resistance to ischemia/reperfusion injury. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Shock, Septic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34478263&form=6&db=m c-di-GMP Induces COX-2 Expression in Macrophages in a STING-Independent Manner. causal interaction,unassigned 4,0
1.14.99.1 Shoulder Dislocation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34074169&form=6&db=m Increased nerve growth factor expression in the synovial tissues of patients with rotator cuff tears. diagnostic usage,ongoing research,unassigned 2,3,0
1.14.99.1 Shoulder Impingement Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15517155&form=6&db=m [In vitro effects of diclofenac and selective cyclooxygenase-2 inhibitors on prostaglandin release from inflamed bursa subacromialis tissue in patients with subacromial syndrome] ongoing research,unassigned 2,0
1.14.99.1 Shoulder Pain http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17004263&form=6&db=m Expression of interleukin-1beta, cyclooxygenase-2, and prostaglandin E2 in a rotator cuff tear in rabbits. unassigned -
1.14.99.1 Sialadenitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17049779&form=6&db=m Increased expression of cyclooxygenase-2 and Ki-67 are associated with malignant transformation of pleomorphic adenoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Silicosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1550684&form=6&db=m Enhanced release of prostaglandin E2 from macrophages of rats with silicosis. ongoing research,unassigned 4,0
1.14.99.1 Silicosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15665045&form=6&db=m Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. therapeutic application,unassigned 1,0
1.14.99.1 Sinusitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8012649&form=6&db=m Asthma in children and ASA intolerance. causal interaction,unassigned 4,0
1.14.99.1 Sinusitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9543076&form=6&db=m Expression of cyclo-oxygenase 1 and 2 proteins in upper respiratory mucosa. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Sinusitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12743549&form=6&db=m Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Sinusitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15921208&form=6&db=m New immunohistologic findings on the differential role of cyclooxygenase 1 and cyclooxygenase 2 in nasal polyposis. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Sinusitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23639710&form=6&db=m Mechanisms of aspirin desensitization. causal interaction,unassigned 1,0
1.14.99.1 Sinusitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27712767&form=6&db=m Mechanisms of Benefit with Aspirin Therapy in Aspirin-Exacerbated Respiratory Disease. causal interaction,unassigned 2,0
1.14.99.1 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8858986&form=6&db=m Characterization of receptor subtypes involved in prostanoid-induced conjunctival pruritus and their role in mediating allergic conjunctival itching. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14575647&form=6&db=m Cyclooxygenases in the skin: pharmacological and toxicological implications. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15327557&form=6&db=m Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19627000&form=6&db=m [The expressions of PPAR-gamma, COX-2 in the lesions of patients with condyloma acuminatum and bowenoid papulosis] unassigned -
1.14.99.1 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519141&form=6&db=m 1-methylnicotinamide effects on the selected markers of endothelial function, inflammation and haemostasis in diabetic rats. causal interaction,unassigned 2,0
1.14.99.1 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21403919&form=6&db=m Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line. causal interaction,unassigned 3,0
1.14.99.1 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21601872&form=6&db=m Immunohistochemical Detection of COX-2 in Feline and Canine Actinic Keratoses and Cutaneous Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Skin Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25278440&form=6&db=m Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. unassigned -
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9635856&form=6&db=m COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,3
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10417761&form=6&db=m Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10449029&form=6&db=m Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10678579&form=6&db=m Molecular pathology of cyclooxygenase-2 in neoplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11090967&form=6&db=m Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11162632&form=6&db=m Ultraviolet B(UVB)-induced cox-2 expression in murine skin: an immunohistochemical study. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11401676&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in skin cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11439356&form=6&db=m Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12056955&form=6&db=m Celecoxib, a cyclooxygenase 2 inhibitor as a potential chemopreventive to UV-induced skin cancer: a study in the hairless mouse model. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12056966&form=6&db=m Cyclooxygenase inhibitors for skin cancer prevention: are they beneficial enough? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086405&form=6&db=m Is cyclooxygenase-2 important in skin carcinogenesis? causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126310&form=6&db=m Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12164941&form=6&db=m Ketoconazole suppresses prostaglandin E(2)-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12202973&form=6&db=m NSAIDs in dermatologic therapy: review and preview. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12370831&form=6&db=m The role of p38 in UVA-induced cyclooxygenase-2 expression in the human keratinocyte cell line, HaCaT. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12636206&form=6&db=m In vitro growth inhibition by indomethacin on human oral squamous cell carcinoma lines synergistically suppressed by all-trans retinoic acid correlating to apoptosis. causal interaction,unassigned 1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12847753&form=6&db=m The role of cyclooxygenase-2 in the pathogenesis of skin cancer. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949841&form=6&db=m Chemotherapeutic efficacy of topical celecoxib in a murine model of ultraviolet light B-induced skin cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14499495&form=6&db=m Enhanced expression of cylooxygenase-2 by UV in aged human skin in vivo. causal interaction,unassigned 1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14502644&form=6&db=m Inhibition of cutaneous ultraviolet light B-mediated inflammation and tumor formation with topical celecoxib treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15018897&form=6&db=m UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. causal interaction,unassigned 4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15175041&form=6&db=m Treatment with 5-fluorouracil and celecoxib displays synergistic regression of ultraviolet light B-induced skin tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491425&form=6&db=m Cyclooxygenase-2 expression and angiogenesis in squamous cell carcinoma of the skin and its precursors: a paired immunohistochemical study of 35 cases. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492414&form=6&db=m Negative feedback regulation of phosphatidylinositol 3-kinase/Akt pathway by over-expressed cyclooxygenase-2 in human epidermal cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15619216&form=6&db=m COX-2 expression correlates with microvessel density in non-melanoma skin cancer from renal transplant recipients and immunocompetent individuals. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15748645&form=6&db=m Photochemoprevention of ultraviolet B signaling and photocarcinogenesis. causal interaction,unassigned 4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16023763&form=6&db=m Celecoxib, a cyclooxygenase-2 inhibitor, prevents induction of liver preneoplastic lesions in rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16185283&form=6&db=m Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer. causal interaction,unassigned 1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16279229&form=6&db=m [Cyclooxygenases in the skin] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16417238&form=6&db=m Importance of the EP(1) receptor in cutaneous UVB-induced inflammation and tumor development. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778813&form=6&db=m A new wrinkle on topical vitamin E and photo-inflammation: Mechanistic studies of a hydrophilic gamma-tocopherol derivative compared with alpha-tocopherol. unassigned -
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16921490&form=6&db=m Benzo[a]pyrene diol-epoxide (B[a]PDE) upregulates COX-2 expression through MAPKs/AP-1 and IKKbeta/NF-kappaB in mouse epidermal Cl41 cells. causal interaction,unassigned 1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17238138&form=6&db=m Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17443745&form=6&db=m A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesis. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17488409&form=6&db=m Genetically determined susceptibility to COX-2 inhibitors: a report of exaggerated responders to diclofenac 3% gel in the treatment of actinic keratoses. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17546626&form=6&db=m The cyclooxygenase-2-mediated prostaglandin signaling is causally related to epithelial carcinogenesis. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17578436&form=6&db=m Association of functional gene variants in the regulatory regions of COX-2 gene (PTGS2) with nonmelanoma skin cancer after organ transplantation. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17645375&form=6&db=m The role of topical cyclo-oxygenase-2 inhibitors in skin cancer: treatment and prevention. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18194346&form=6&db=m Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19174152&form=6&db=m Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19226541&form=6&db=m Effect of non-steroidal anti-inflammatory drugs on non-melanoma skin cancer incidence in the SKICAP-AK trial. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20096264&form=6&db=m Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1. unassigned -
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20399617&form=6&db=m TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20445548&form=6&db=m Influence of Cyclooxygenase-2 (COX-2) Gene Promoter Polymorphism at Position -765 on Skin Cancer after Renal Transplantation. ongoing research,unassigned 3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21115882&form=6&db=m Chemoprevention of nonmelanoma skin cancer with celecoxib: a randomized, double-blind, placebo-controlled trial. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21268131&form=6&db=m p38 MAP kinase plays a functional role in UVB-Induced mouse skin carcinogenesis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21858326&form=6&db=m Activation of p38 MAP kinase and JNK pathways by UVA irradiation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22012553&form=6&db=m The role of the EP receptors for prostaglandin E2 in skin and skin cancer. causal interaction,unassigned 1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22038018&form=6&db=m Cyclooxygenase-dependent signaling is causally linked to non-melanoma skin carcinogenesis: pharmacological, genetic, and clinical evidence. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22159575&form=6&db=m Role of COX-2 activity and CRP levels in patients with non-melanoma skin cancer. -765G>C PTGS2 polymorphism and NMSC risk. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22506937&form=6&db=m siRNA-mediated knock-down of COX-2 in melanocytes suppresses melanogenesis. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469308&form=6&db=m Cell-type-specific roles for COX-2 in UVB-induced skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24632333&form=6&db=m Photodynamic Therapeutic Role of Indocyanine Green in Tumor-Associated Inflammation in Skin Cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24804836&form=6&db=m Cyclooxygenases: Mediators of UV-Induced Skin Cancer and Potential Targets for Prevention. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25063587&form=6&db=m Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25320180&form=6&db=m SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25557612&form=6&db=m Arachidonoyl-ethanolamide activates endoplasmic reticulum stress-apoptosis in tumorigenic keratinocytes: Role of cyclooxygenase-2 and novel J-series prostamides. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25616102&form=6&db=m Genetics and nonmelanoma skin cancer in kidney transplant recipients. causal interaction,unassigned 3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26604686&form=6&db=m The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27046744&form=6&db=m LONG-TERM USE OF A NEW TOPICAL FORMULATION CONTAINING PIROXICAM 0.8% AND SUNSCREEN: EFFICACY AND TOLERABILITY ON ACTINIC KERATOSIS. A PROOF OF CONCEPT STUDY. causal interaction,unassigned 1,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28150108&form=6&db=m Cyclooxygenase in Cancer Prevention and Treatments for Actinic Keratosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28230039&form=6&db=m Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28724634&form=6&db=m Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29147402&form=6&db=m Immunohistochemical Analysis of Cyclooxygenase-2 in Non-Melanocytic Skin Cancer: Correlation With Morphological Subtype and Histologic Grade. causal interaction,diagnostic usage,unassigned 1,2,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29156646&form=6&db=m Inhibition of bcl-2 and cox-2 Protein Expression after Local Application of a New Carmustine-Loaded Clinoptilolite-Based Delivery System in a Chemically Induced Skin Cancer Model in Mice. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29282394&form=6&db=m Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series of 10 Cases. causal interaction,unassigned 3,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29568008&form=6&db=m Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29714143&form=6&db=m Cutaneous Application of Celecoxib for Inflammatory and Cancer Diseases. therapeutic application,unassigned 4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30118847&form=6&db=m Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-l-Leucine and its cytotoxicity for normal and cancer human cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31571864&form=6&db=m A comparative study: the prospective influence of nanovectors in leveraging the chemopreventive potential of COX-2 inhibitors against skin cancer. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31696069&form=6&db=m The role of immunohistochemistry expression of COX-2 in differentiating pigmented benign and malignant skin neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Sleep Apnea Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25873764&form=6&db=m Excessive daytime sleepiness is associated with changes in salivary inflammatory genes transcripts. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Sleep Apnea Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28300223&form=6&db=m Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21845875&form=6&db=m [Cyclooxygenase-2 overexpression and vascular endothelial growth factor expression in pharyngeal tissue of patients with OSAHS correlates with angiogenesis]. causal interaction,unassigned 2,0
1.14.99.1 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28676625&form=6&db=m Liver X Receptor Gene Expression is Enhanced in Children with Obstructive Sleep Apnea-Hyperpnoea Syndrome and Cyclooxygenase-2 (COX-2) is Correlated with Severity of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). causal interaction,diagnostic usage,ongoing research,unassigned 3,2,2,0
1.14.99.1 Sleep Apnea, Obstructive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33050416&form=6&db=m Role of the Cyclooxygenase Pathway in the Association of Obstructive Sleep Apnea and Cancer. causal interaction,unassigned 4,0
1.14.99.1 Sleep Deprivation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22694732&form=6&db=m Influence of sleep deprivation and morphine on the expression of inducible nitric oxide synthase and cyclooxygenase-2 in skin of hairless mice. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Sleep Wake Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12965112&form=6&db=m Indomethacin reverts sleep disorders produced by ozone exposure in rats. therapeutic application,unassigned 4,0
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823297&form=6&db=m Expression of cyclooxygenase-2 in human lung carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11062695&form=6&db=m Meloxicam inhibits the growth of non-small cell lung cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11836568&form=6&db=m Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11895880&form=6&db=m Hierarchical clustering of lung cancer cell lines using DNA methylation markers. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15330186&form=6&db=m Survival in small cell lung cancer is independent of tumor expression of VEGF and COX-2. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870920&form=6&db=m Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases. diagnostic usage,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16119982&form=6&db=m Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17602268&form=6&db=m Characterization of the effects of cyclooxygenase-2 inhibition in the regulation of apoptosis in human small and non-small cell lung cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17630920&form=6&db=m Nicotine, lung and cancer. ongoing research,unassigned 2,0
1.14.99.1 Small Cell Lung Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27765529&form=6&db=m Identification of key genes involved in nasopharyngeal carcinoma. causal interaction,diagnostic usage,unassigned 1,1,0
1.14.99.1 Smooth Muscle Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17550381&form=6&db=m Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Soft Tissue Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19143855&form=6&db=m A randomised, double-blind study comparing lumiracoxib with naproxen for acute musculoskeletal pain. therapeutic application,unassigned 2,0
1.14.99.1 Soft Tissue Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22744434&form=6&db=m The effect of nonsteroidal anti-inflammatory drugs on tissue healing. therapeutic application,unassigned 4,0
1.14.99.1 Solitary Kidney http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25234310&form=6&db=m Cyclooxygenase-2, prostaglandin E2, and prostanoid receptor EP2 in fluid flow shear stress-mediated injury in the solitary kidney. causal interaction,unassigned 2,0
1.14.99.1 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3554158&form=6&db=m Molsidomine: alternative approaches to treat myocardial ischemia. therapeutic application,unassigned 1,0
1.14.99.1 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14972745&form=6&db=m Dietary L-arginine restores aspirin-induced endothelial dysfunction in rat aorta. causal interaction,unassigned 4,0
1.14.99.1 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17301605&form=6&db=m Antioxidant is a useful supportive agent for the treatment of coronary vasospasm with endothelial dysfunction in pig. unassigned -
1.14.99.1 Spasm http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20958135&form=6&db=m NS-398 (a Selective Cyclooxygenase-2 Inhibitor) Decreases Agonist-Induced Contraction of the Human Ureter via Calcium Channel Inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Spermatic Cord Torsion http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21420155&form=6&db=m Inflammation and Oxidative Stress in Testicular Torsion: Do They Deserve Intensive Treatment to Save Both Guilty and Innocent Testes? therapeutic application,unassigned 4,0
1.14.99.1 Sphincter of Oddi Dysfunction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28171691&form=6&db=m Toward routine use of nonsteroidal anti-inflammatory drugs for patients undergoing endoscopic retrograde cholangiopancreatography. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Spinal Cord Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21933591&form=6&db=m Quantitative analysis of cyclooxygenase 2 in the posterior longitudinal ligament of cervical spondylotic myelopathy. unassigned -
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3418749&form=6&db=m Traumatic spinal cord injury in rats causes increases in tissue thromboxane but not peptidoleukotrienes. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872457&form=6&db=m Role of cyclooxygenase 2 in acute spinal cord injury. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886082&form=6&db=m Possible involvement of interleukin-1 in cyclooxygenase-2 induction after spinal cord injury in rats. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11063829&form=6&db=m Persistent accumulation of cyclooxygenase-1 (COX-1) expressing microglia/macrophages and upregulation by endothelium following spinal cord injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11275357&form=6&db=m Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11336442&form=6&db=m Reduction of pathological and behavioral deficits following spinal cord contusion injury with the selective cyclooxygenase-2 inhibitor NS-398. therapeutic application,unassigned 4,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12664616&form=6&db=m Cyclooxygenase-2 induction in rat spinal cord injury mediated by proinflammatory tumor necrosis factor-alpha and interleukin-1. ongoing research,unassigned 2,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179440&form=6&db=m Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor (rofecoxib). therapeutic application,unassigned 4,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15312174&form=6&db=m An anti-CD11d integrin antibody reduces cyclooxygenase-2 expression and protein and DNA oxidation after spinal cord injury in rats. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596243&form=6&db=m Localization of cyclooxygenase-2 induced following traumatic spinal cord injury. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16182319&form=6&db=m Analysis of interaction between etoricoxib and tramadol against mechanical hyperalgesia of spinal cord injury in rats. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16648743&form=6&db=m Effects of COX-2 and iNOS inhibitors alone or in combination with olfactory ensheathing cell grafts after spinal cord injury. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21784069&form=6&db=m CD11d integrin blockade reduces the systemic inflammatory response syndrome after spinal cord injury. causal interaction,unassigned 1,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23354604&form=6&db=m Tempol reduces injury area in rat model of spinal cord contusion injury through suppression of iNOS and COX-2 expression. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23901068&form=6&db=m A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25472548&form=6&db=m Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26807121&form=6&db=m Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29152109&form=6&db=m Sevoflurane preconditioning ameliorates traumatic spinal cord injury through caveolin-3-dependent cyclooxygenase-2 inhibition. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29355394&form=6&db=m The Investigation of the Cox-2 Selective Inhibitor Parecoxib Effects in Spinal Cord Injury in Rat. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32629287&form=6&db=m Neuroprotective effect of novel celecoxib derivatives against spinal cord injury via attenuation of COX-2, oxidative stress, apoptosisand inflammation. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,3,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33510092&form=6&db=m High mobility group box 1 mediates inflammatory response of astrocytes via cyclooxygenase 2/prostaglandin E2 signaling following spinal cord injury. causal interaction,unassigned 1,0
1.14.99.1 Spinal Cord Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33742328&form=6&db=m Downregulating lncRNA PVT1 Relieves Astrocyte Overactivation Induced Neuropathic Pain Through Targeting miR-186-5p/CXCL13/CXCR5 Axis. diagnostic usage,unassigned 3,0
1.14.99.1 Spinal Cord Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11340237&form=6&db=m Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in behavioral deficits induced by reversible spinal cord ischemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Spinal Cord Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11707263&form=6&db=m Biomarkers of free radical injury during spinal cord ischemia. causal interaction,unassigned 4,0
1.14.99.1 Spinal Cord Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30625493&form=6&db=m Anti-Inflammatory Effect of Lycopene on Experimental Spinal Cord Ischemia Injury via Cyclooxygenase-2 Suppression. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Spinal Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29636862&form=6&db=m Cyclooxygenase-2 deficiency causes delayed ossification of lumbar vertebral endplates. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Spondylarthropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2212008&form=6&db=m Autoantibodies to the HLA-B27 sequence cross-react with the hypothetical peptide from the arthritis-associated Shigella plasmid. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Spondylitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18627117&form=6&db=m Celecoxib: new indication. Ankylosing spondylitis: no pain justifies the use of a cox-2 inhibitor. Patients still exposed to unjustified risks. therapeutic application,unassigned 4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=861066&form=6&db=m Association of renal papillary necrosis and ankylosing spondylitis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9433877&form=6&db=m Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11212158&form=6&db=m Efficacy of celecoxib, a cyclooxygenase 2-specific inhibitor, in the treatment of ankylosing spondylitis: a six-week controlled study with comparison against placebo and against a conventional nonsteroidal antiinflammatory drug. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15818702&form=6&db=m Evaluation of the efficacy of etoricoxib in ankylosing spondylitis: results of a fifty-two-week, randomized, controlled study. therapeutic application,unassigned 4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15974939&form=6&db=m COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16582683&form=6&db=m Update on nonsteriodal anti-inflammatory drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971283&form=6&db=m Economic evaluation of etoricoxib versus non-selective NSAIDs in the treatment of ankylosing spondylitis in the UK. therapeutic application,unassigned 4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18627117&form=6&db=m Celecoxib: new indication. Ankylosing spondylitis: no pain justifies the use of a cox-2 inhibitor. Patients still exposed to unjustified risks. therapeutic application,unassigned 4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19327236&form=6&db=m Effects of celecoxib on the expression of osteoprotegerin, energy metabolism and cell viability in cultured human osteoblastic cells. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27790020&form=6&db=m Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAIDs and COX-2 inhibitors: a systematic review and network analyses. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28403136&form=6&db=m Influence of CYP2C9 and COX-2 Genetic Polymorphisms on Clinical Efficacy of Non-Steroidal Anti-Inflammatory Drugs in Treatment of Ankylosing Spondylitis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30774225&form=6&db=m Meloxicam in the management of post-operative pain: Narrative review. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33140463&form=6&db=m Evaluation of the oral administration of ?-l-guluronic acid on COX-1 and COX-2 gene expression profile in ankylosing spondylitis patients. ongoing research,unassigned 2,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33565113&form=6&db=m Connection of COX-2 variants to ankylosing spondylitis susceptibility. ongoing research,unassigned 2,0
1.14.99.1 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34304363&form=6&db=m Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism. therapeutic application,unassigned 4,0
1.14.99.1 Spondylolisthesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16845338&form=6&db=m High-grade slippage of the lumbar spine in a rat model of spondylolisthesis: effects of cyclooxygenase-2 inhibitor on its deformity. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Spotted Fever Group Rickettsiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16926398&form=6&db=m Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Spotted Fever Group Rickettsiosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22522044&form=6&db=m Regulation of inducible heme oxygenase and cyclooxygenase isozymes in a mouse model of spotted fever group rickettsiosis. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10070952&form=6&db=m Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10595745&form=6&db=m A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10668483&form=6&db=m Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11587608&form=6&db=m Correlation of expression of cyclooxygenase-2, vascular endothelial growth factor, and peroxisome proliferator-activated receptor delta with head and neck squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11668514&form=6&db=m Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745262&form=6&db=m COX-2 expression in dysplasia of the head and neck: correlation with elF4E. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12196922&form=6&db=m Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12393863&form=6&db=m Hepatocyte growth factor inhibits anoikis by induction of activator protein 1-dependent cyclooxygenase-2. Implication in head and neck squamous cell carcinoma progression. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12459168&form=6&db=m Correlation between nitric oxide and cyclooxygenase-2 pathways in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12738747&form=6&db=m The cyclooxygenase 2-selective inhibitor NS398 inhibits proliferation of oral carcinoma cell lines by mechanisms dependent and independent of reduced prostaglandin E2 synthesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12874003&form=6&db=m Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12875991&form=6&db=m Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12883661&form=6&db=m Correlation of cyclooxygenase-2 pathway and VEGF expression in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949405&form=6&db=m An immunohistochemical study of cyclooxygenase-2 expression in various feline neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12969226&form=6&db=m Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13679206&form=6&db=m Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566822&form=6&db=m The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14587561&form=6&db=m Selective inhibition of cyclooxygenase 2 induces p27kip1 and skp2 in oral squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14626203&form=6&db=m Differential expression pattern of cyclooxygenase-1 and -2 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14630280&form=6&db=m NS 398 radiosensitizes an HNSCC cell line by possibly inhibiting radiation-induced expression of COX-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14969817&form=6&db=m Overexpression of cyclooxygenase-2 is associated with radioresistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15014019&form=6&db=m Prognostic significance of cyclooxygenase-2 in oropharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15254428&form=6&db=m Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and metastatic head and neck cancer and its modulation by celecoxib. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15272284&form=6&db=m COX-2 expression correlates with VEGF-C and lymph node metastases in patients with head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15287038&form=6&db=m Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15327557&form=6&db=m Cyclooxygenase-2 is a possible target of treatment approach in conjunction with photodynamic therapy for various disorders in skin and oral cavity. causal interaction,ongoing research,therapeutic application,unassigned 2,4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15461861&form=6&db=m Cyclooxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15482327&form=6&db=m Nimesulide and indomethacin induce apoptosis in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15645120&form=6&db=m Promotion of cell differentiation, and suppression of cell growth and cyclooxygenase-2 expression by differentiation-inducing agents in human oral squamous carcinoma SCC25 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15886845&form=6&db=m [The expressions of cyclooxygenase-2 (Cox-2),VEGF in oral squamous cell carcinoma and precancerous lesions and their significances] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16027288&form=6&db=m A replication-selective adenoviral vector for head and neck cancers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16035618&form=6&db=m Inhibition of cyclooxygenase-2 suppresses invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 and CD44. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16176003&form=6&db=m [Nuclear factor kappaB/p65 and cyclooxygenase-2 expression and clinic significance in human laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16285555&form=6&db=m [Relationship between the expression of cyclooxygenase-2 and microvessel density in oral squamnous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16376136&form=6&db=m Amphiregulin as a tumor promoter for oral squamous cell carcinoma: involvement of cyclooxygenase 2. diagnostic usage,therapeutic application,unassigned 2,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16494037&form=6&db=m [The expressiong of cyclooxygenase-2 in laryngeal squamous cell carcinoma and its relationship with MVD] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16711020&form=6&db=m Expression of vascular endothelial growth factor and cyclooxygenase-2 in laryngeal squamous cell carcinoma and its significance. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16720448&form=6&db=m Simultaneous expression of cyclooxygenase-2 and microsomal prostaglandin E synthase in squamous cell carcinoma of the larynx. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16952367&form=6&db=m COX-1 and COX-2 Expression in Feline Oral Squamous Cell Carcinoma. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17383864&form=6&db=m Study of feline oral squamous cell carcinoma: potential target for cyclooxygenase inhibitor treatment. therapeutic application,unassigned 4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17875728&form=6&db=m Expansion of human T regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17888194&form=6&db=m Expression of cyclooxygenase-2, vascular endothelial growth factor and matrix metalloproteinase-2 in patients with primary laryngeal carcinoma: a tissue microarray study. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18027256&form=6&db=m Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18062281&form=6&db=m [The expression and significance of HIF-1alpha and COX-2 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18202791&form=6&db=m Differential effects of selective cyclooxygenase-2 inhibitors in inhibiting proliferation and induction of apoptosis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18225538&form=6&db=m The effects of reactive species on the tumorigenic phenotype of human head and neck squamous cell carcinoma (HNSCC) cells. causal interaction,unassigned 4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18234542&form=6&db=m Polymorphisms of COX-2 -765G>C and p53 codon 72 and risks of oral squamous cell carcinoma in a Taiwan population. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18284542&form=6&db=m A study of phosphorylated ERK1/2 and COX-2 in early stage (T1-T2) oral squamous cell carcinomas. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18288396&form=6&db=m Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18330256&form=6&db=m [Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18346877&form=6&db=m Decreased gene expression of human beta-defensin-1 in the development of squamous cell carcinoma of the oral cavity. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18446786&form=6&db=m Resveratrol causes COX-2- and p53-dependent apoptosis in head and neck squamous cell cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18536521&form=6&db=m COX-2 expression in oral lichen planus. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18642283&form=6&db=m Prostaglandin E(2) pathway in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18695912&form=6&db=m Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18800677&form=6&db=m [The expression of COX-2 mRNA and protein in human laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18805045&form=6&db=m Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18922923&form=6&db=m Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19074839&form=6&db=m Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19123475&form=6&db=m Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19239949&form=6&db=m Immunoexpression of cyclooxygenase-2 and p53 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19241124&form=6&db=m Inhibition of cyclooxygenase-2 suppresses the invasiveness of oral squamous cell carcinoma cell lines via down-regulation of matrix metalloproteinase-2 production and activation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19278989&form=6&db=m PGE2 production in oral cancer cell lines is COX-2-dependent. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289704&form=6&db=m 7beta-hydroxycholesterol induces apoptosis and regulates cyclooxygenase 2 in head and neck squamous cell carcinoma. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19289707&form=6&db=m Cyclooxygenase 2 promoter-based replication-selective adenoviral vector for hypopharyngeal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,2
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19300368&form=6&db=m Expression of pro-inflammatory protein, iNOS, VEGF and COX-2 in Oral Squamous Cell Carcinoma (OSCC), relationship with angiogenesis and their clinico-pathological correlation. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19484991&form=6&db=m [Expression and clinical significance of hypoxia-inducible factor-1alpha and cyclooxygenase-2 in laryngeal squamous cell carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19737986&form=6&db=m Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19758248&form=6&db=m Epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines is mediated through extracellular signal-regulated kinase 1/2 and p38 but is Src and nuclear factor-kappa B independent. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19789323&form=6&db=m Proinflammatory mediators upregulate snail in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19821125&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19843689&form=6&db=m Elevated Levels of Urinary Prostaglandin E Metabolite Indicate a Poor Prognosis in Ever Smoker Head and Neck Squamous Cell Carcinoma Patients. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20025602&form=6&db=m Dual EGFR and COX-2 inhibition as a novel approach to targeting head and neck squamous cell carcinoma. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20034753&form=6&db=m Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20051374&form=6&db=m Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20121928&form=6&db=m c-Jun N-terminal kinase negatively regulates epidermal growth factor-induced cyclooxygenase-2 expression in oral squamous cell carcinoma cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,3,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20222044&form=6&db=m Differential effects between cyclooxygenase-2 inhibitors and siRNA on vascular endothelial growth factor production in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20412400&form=6&db=m Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20501859&form=6&db=m Combination effects of salvianolic acid B with low-dose celecoxib on inhibition of head and neck squamous cell carcinoma growth in vitro and in vivo. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20558731&form=6&db=m Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20620096&form=6&db=m Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20717005&form=6&db=m Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20951077&form=6&db=m A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20960565&form=6&db=m Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069476&form=6&db=m COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21177768&form=6&db=m Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-{kappa}B and STAT3 pathways in head and neck cancer cells. therapeutic application,unassigned 2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21301321&form=6&db=m The influence of cyclooxygenase-1 expression on the efficacy of cyclooxygenase-2 inhibition in head and neck squamous cell carcinoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21481000&form=6&db=m Cyclooxygenase-2 expression in oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21656078&form=6&db=m The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21923838&form=6&db=m DNA polymorphisms and tissue cyclooxygenase-2 expression in oral lichen planus: a case-control study. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21962280&form=6&db=m 5-lipoxygenase expression and tepoxalin-induced cell death in squamous cell carcinomas in cats. ongoing research,unassigned 4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22247036&form=6&db=m Cyclooxygenase-2 expression and clinical parameters in laryngeal squamous cell carcinoma, vocal fold nodule, and laryngeal atypical hyperplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22308510&form=6&db=m Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22442604&form=6&db=m Overexpression of COX-2 in oral squamous cell carcinoma patients undergoing chemoradiotherapy. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22665749&form=6&db=m Comparison of COX2 expression between oral squamous cell carcinoma, leukoplakia and normal mucosa. ongoing research,unassigned 3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22735610&form=6&db=m Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22818026&form=6&db=m Nuclear factor ?B and cyclooxygenase-2 immunoexpression in oral dysplasia and oral squamous cell carcinoma. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22828609&form=6&db=m Apricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,1,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22887904&form=6&db=m Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22993614&form=6&db=m Relation between proinflammatory mediators and epithelial-mesenchymal transition in head and neck squamous cell carcinoma. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23135108&form=6&db=m [The influence of COX-2 depressant in angiogenesis of oral squamous cell carcinoma]. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23179937&form=6&db=m High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23679684&form=6&db=m Effects of celecoxib treatment over the AKT pathway in head and neck squamous cell carcinoma. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23687559&form=6&db=m The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor. ongoing research,unassigned 4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23790336&form=6&db=m COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,1,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23851751&form=6&db=m Expression of cyclooxygenase-2, 12-lipoxygenase, and inducible nitric oxide synthase in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24019861&form=6&db=m Expression of COX-2, CD44v6 and CD147 and Relationship with Invasion and Lymph Node Metastasis in Hypopharyngeal Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085777&form=6&db=m Chemoprevention of Head and Neck Cancer with Celecoxib and Erlotinib: Results of a Phase 1b and Pharmacokinetic Study. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24374907&form=6&db=m Comprehensive analysis of HPV expression in laryngeal squamous cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24469360&form=6&db=m Association between cyclooxygenase-2 gene polymorphisms and head and neck squamous cell carcinoma risk. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24631063&form=6&db=m Piroxicam inhibits Masitinib-induced cyclooxygenase 2 expression in oral squamous cell carcinoma cells in vitro. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24692703&form=6&db=m Endoplasmic Reticulum Stress Response as a Possible Mechanism of Cyclooxygenase-2-independent Anticancer Effect of Celecoxib. ongoing research,unassigned 4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24727329&form=6&db=m Erlotinib, erlotinib-sulindac vs. placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24887090&form=6&db=m Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25169079&form=6&db=m The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25198789&form=6&db=m Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25256272&form=6&db=m Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25328959&form=6&db=m Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25579548&form=6&db=m Cyclo-oxygenase-2 expression in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25595899&form=6&db=m Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25635769&form=6&db=m Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25776499&form=6&db=m The cancer pain related factors affected by celecoxib together with cetuximab in head and neck squamous cell carcinoma. diagnostic usage,therapeutic application,unassigned 2,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26218314&form=6&db=m Expression and clinical implication of cyclooxygenase-2 and e-cadherin in oral squamous cell carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26369479&form=6&db=m Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,1,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26568042&form=6&db=m Cyclooxygenase-2-1195G>A Polymorphism and Head and Neck Squamous Cell Carcinoma Susceptibility: A Meta-Analysis of 1564 Cases and 2346 Controls. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26722300&form=6&db=m Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-?B in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27086487&form=6&db=m Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27412115&form=6&db=m COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27577989&form=6&db=m Combined Analysis of Vascular Endothelial Growth Factor Expression with Cyclooxygenase-2 and Mast Cell Density in Oral Squamous Cell Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27628320&form=6&db=m Studies on the Contribution of Cox-2 Expression in the Progression of Oral Squamous Cell Carcinoma and H-Ras Activation. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27941877&form=6&db=m Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28489236&form=6&db=m Histologic correlation of VEGF and COX-2 expression with tumor size in squamous cell carcinoma of the larynx and hypopharynx. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29492204&form=6&db=m Stromal versus tumoral inflammation differentially contribute to metastasis and poor survival in laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30104530&form=6&db=m CD147 and Cyclooxygenase Expression in Feline Oral Squamous Cell Carcinoma. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30674365&form=6&db=m Significance of immunohistochemical overexpression of cyclooxygenase-2 in overall and disease-free survival of oral squamous cell carcinoma patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30900666&form=6&db=m Immunohistochemical expression of cyclooxygenase-2 in oral squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31244433&form=6&db=m COX-2 Docking Structural Analysis with Phytochemical Extracts of Rosemary: A Possible Cytotoxicity on Head and Neck Squamous Cell Carcinoma Cell Line (HEp-2). diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350224&form=6&db=m Cyclooxygenase and CD147 expression in oral squamous cell carcinoma patient samples and cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31523430&form=6&db=m The therapeutic activity of curcumin through its anti-cancer potential on oral squamous cell carcinoma: A study on Sprague Dawley rat. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31648572&form=6&db=m Radiosensitizing Potential of Curcumin in Different Cancer Models. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31938347&form=6&db=m CD44high/ESAlow squamous cell carcinoma cell-derived prostaglandin E2 confers resistance to 5-fluorouracil-induced apoptosis in CD44high/ESAhigh cells. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32173393&form=6&db=m Chemopreventive activity of Tualang honey against oral squamous cell carcinoma-in vivo. causal interaction,unassigned 4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32227417&form=6&db=m Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33660890&form=6&db=m Evaluation of HPV and EBV in OSCC and the expression of p53, p16, E-cadherin, COX-2, MYC, and MLH1. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33751829&form=6&db=m The role of COX expression in the prognostication of overall survival of canine and feline cancer: A systematic review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33967512&form=6&db=m Immunohistochemical analysis and correlation of cyclooxygenase-2 expression status with clinicopathological parameters in head and neck squamous cell carcinomas: An Indian perspective. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34084214&form=6&db=m Cyclooxygenase-2 expression is associated with chemoresistance through cancer stemness property in hypopharyngeal carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094895&form=6&db=m Intersecting Mechanisms of Hypoxia and Prostaglandin E2-Mediated Inflammation in the Comparative Biology of Oral Squamous Cell Carcinoma. unassigned -
1.14.99.1 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34395287&form=6&db=m Digital Pathology Scoring of Immunohistochemical Staining Reliably Identifies Prognostic Markers and Anatomical Associations in a Large Cohort of Oral Cancers. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 ST Elevation Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27122707&form=6&db=m Do Not Use Cycloxigenase-2 Inhibitors in STEMI. therapeutic application,unassigned 4,0
1.14.99.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9065483&form=6&db=m p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1beta. ongoing research,unassigned 3,0
1.14.99.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298620&form=6&db=m Correlation of MAP kinases with COX-2 induction differs between MKN45 and HT29 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15358633&form=6&db=m n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16966442&form=6&db=m Cyclooxygenase-2 expression in normal and neoplastic canine mammary cell lines. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18817855&form=6&db=m Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26363168&form=6&db=m Autophagy is deficient and inversely correlated with COX-2 expression in nasal polyps: a novel insight into the inflammation mechanism. causal interaction,unassigned 4,0
1.14.99.1 Starvation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28333553&form=6&db=m Cyclooxygenase-2 Induction by Amino Acid Deprivation Requires p38 Mitogen-Activated Protein Kinase in Human Glioma Cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8069664&form=6&db=m The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15571975&form=6&db=m Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677768&form=6&db=m Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16806953&form=6&db=m Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17029965&form=6&db=m CRE-mediated transcription and COX-2 expression in the pilocarpine model of status epilepticus. ongoing research,unassigned 2,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18076646&form=6&db=m Age-dependent cyclooxygenase-2 induction and neuronal damage after status epilepticus in the postnatal rat hippocampus. ongoing research,unassigned 2,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18988310&form=6&db=m Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19786037&form=6&db=m COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,2
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20353773&form=6&db=m The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20643531&form=6&db=m Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21609430&form=6&db=m Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22016518&form=6&db=m Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22323596&form=6&db=m Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22765917&form=6&db=m Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401547&form=6&db=m Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25453777&form=6&db=m Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. unassigned -
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25600211&form=6&db=m Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27165595&form=6&db=m [Effects of cyclooxygenase-2 selective inhibitor celecoxib on the expression of major vault protein in rats with status epilepticus]. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212985&form=6&db=m Nonsteroidal anti-inflammatory drugs in clinical and experimental epilepsy. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Status Epilepticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28987270&form=6&db=m Involvement of nitrergic system in anticonvulsant effect of zolpidem in lithium-pilocarpine induced status epilepticus: Evaluation of iNOS and COX-2 genes expression. unassigned -
1.14.99.1 Stevens-Johnson Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16180941&form=6&db=m Comparison of reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis in association with selective COX-2 inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Stillbirth http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22891569&form=6&db=m [Developmental toxicity of the over-the-counter analgetics and antypiretics]. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Stomach Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298601&form=6&db=m Sex differences in mucosal response to Helicobacter pylori infection in the stomach and variations in interleukin-8, COX-2 and trefoil factor family 1 gene expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Stomach Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20388956&form=6&db=m Beta-carotene inhibits Helicobacter pylori-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in human gastric epithelial AGS cells. causal interaction,unassigned 3,0
1.14.99.1 Stomach Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24833939&form=6&db=m COX-2 Gene Promoter Methylation in Patients Infected with Helicobacter Pylori. diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Stomach Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30079321&form=6&db=m Quantitative analysis of COX-2 promoter methylation in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Stomach Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328138&form=6&db=m Interaction of Cyclooxygenase-2 with Helicobacter pylori Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in Helicobacter pylori-Related Gastric Diseases. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9679948&form=6&db=m Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9696706&form=6&db=m Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9872498&form=6&db=m Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10404093&form=6&db=m Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10656441&form=6&db=m Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10690533&form=6&db=m Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11161397&form=6&db=m Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11176123&form=6&db=m Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192946&form=6&db=m Helicobacter pylori, gastrin and cyclooxygenases in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11205258&form=6&db=m Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11223821&form=6&db=m Expression of cyclooxygenase-2 in human gastric adenomas and adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11289104&form=6&db=m Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310828&form=6&db=m Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11403917&form=6&db=m Inverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11424449&form=6&db=m [COX-2 expression in gastric cancers] diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11448905&form=6&db=m Expression of cyclooxygenase-2 in dysplasia of the stomach and in intestinal-type gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566494&form=6&db=m Expression of nitric oxide synthase, cyclooxygenase, and p53 in different stages of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11601879&form=6&db=m Nonsteroidal anti-inflammatory drugs for treatment of advanced gastric cancer: cyclooxygenase-2 is involved in hepatocyte growth factor mediated tumor development and progression. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11606854&form=6&db=m Interaction between cyclooxygenase-2 and inducible nitric oxide synthase in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11686835&form=6&db=m Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11758830&form=6&db=m MAPK (ERK2) kinase--a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11774276&form=6&db=m Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11819707&form=6&db=m Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection, histological types and staging. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854904&form=6&db=m Growth inhibition and apoptosis induction of Sulindac on Human gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943943&form=6&db=m Cyclooxygenase-2 expression in early gastric cancer, intestinal metaplasia and Helicobacter pylori infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11943946&form=6&db=m Cyclooxygenase-2 expression is increased in early intestinal-type gastric cancer and gastric mucosa with intestinal metaplasia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11966873&form=6&db=m Effect of Helicobacter pylori-induced cyclooxygenase-2 on gastric epithelial cell kinetics: implication for gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12037025&form=6&db=m Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12086398&form=6&db=m Oxidant-sensitive transcription factor and cyclooxygenase-2 by Helicobacter pylori stimulation in human gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126507&form=6&db=m [Association between Helicobacter pylori cagA strain infection and expression of cyclooxygenase 2 in gastric carcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12173384&form=6&db=m Expression of cyclooxygenase-2 in primary and remnant gastric carcinoma: comparing it with p53 accumulation, Helicobacter pylori infection, and vascular endothelial growth factor expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203123&form=6&db=m Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-beta(1)-dependent pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12324457&form=6&db=m Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12421501&form=6&db=m [Antisense inhibition of cyclooxygenase-2 reduces malignant phenotype of gastric cancer cells] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452062&form=6&db=m [Significance of COX-2, p53, proliferating cell nuclear antigen and nm23 expressions in gastric cancer and its behavior] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12452063&form=6&db=m [Influence of selective cyclooxygenase-2 inhibitor on proliferation of human gastric cancer cells] causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12485493&form=6&db=m [Delayed rectifier K(+) channel regulated by cyclooxygenase-2 in human gastric cancer cell] diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12532177&form=6&db=m The immunogenetics and pathogenesis of gastric cancer. Highlights of the First Sino-European Workshop on the Immunogenetics and Pathogenesis of Gastric Cancer. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12532440&form=6&db=m Association of cyclooxygenase-2 expression with Hp-cagA infection in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12532441&form=6&db=m Expression of cyclooxygenase-2 and clinicopathologic features in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12542979&form=6&db=m Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible? causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12584173&form=6&db=m 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12592098&form=6&db=m Cyclooxygenase-2 expression is associated with well-differentiated and intestinal-type pathways in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12605827&form=6&db=m [Helicobacter pylori, cyclooxygenase-2 and gastric cancer] ongoing research,unassigned 2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12606945&form=6&db=m Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12674216&form=6&db=m Influence of gastrin on the expression of cyclooxygenase-2, hepatocyte growth factor and apoptosis-related proteins in gastric epithelial cells. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12679908&form=6&db=m Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12684668&form=6&db=m Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12686777&form=6&db=m Expression of COX-2 in stomach cancers and its relation to their biological features. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767510&form=6&db=m Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12781040&form=6&db=m Effects of combined octreotide and aspirin on the growth of gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811200&form=6&db=m COX-2 and angiogenesis in gastric cancer. causal interaction,unassigned 3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12811205&form=6&db=m Cyclooxygenase-2 overexpression correlates with vascular endothelial growth factor expression and tumor angiogenesis in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12823157&form=6&db=m Effect of cyclooxygenase-2 inhibition on human Helicobacter pylori gastritis: mechanisms underlying gastrointestinal safety and implications for cancer chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12910695&form=6&db=m [The effects of selective cyclooxygenase-2 inhibitors on the growth of gastric adenocarcinoma] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12929571&form=6&db=m Combination chemotherapy with JTE-522, a novel selective cyclooxygenase-2 inhibitor, and cisplatin against gastric cancer cell lines in vitro and in vivo. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14520691&form=6&db=m Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529406&form=6&db=m Cyclooxygenase-2 inhibition and gastric cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14531897&form=6&db=m Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. causal interaction,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532971&form=6&db=m Cyclooxygenase-2 upregulates vascular endothelial growth factor expression and angiogenesis in human gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566822&form=6&db=m The effect of nitric oxide on cyclooxygenase-2 (COX-2) overexpression in head and neck cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14614005&form=6&db=m Higher gastric cycloxygenase-2 expression and precancerous change in Helicobacter pylori-infected relatives of gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14627349&form=6&db=m Influence of COX-2 inhibition by rofecoxib on serum and tumor progastrin and gastrin levels and expression of PPARgamma and apoptosis-related proteins in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14716842&form=6&db=m Expression of COX-2 proteins in gastric mucosal lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14724149&form=6&db=m Chemoprevention of gastric cancer by celecoxib in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14960510&form=6&db=m Effect of peroxisome proliferator activated receptor gamma ligands on growth and gene expression profiles of gastric cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14962510&form=6&db=m A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14991895&form=6&db=m Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: a molecular pathway of H pylori-related gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15022477&form=6&db=m [Research on relationships of gastric cancer with serum trace elements, Helicobacter pylori and COX-2 in gastric tissue] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15116331&form=6&db=m Cyclooxygenase-2 expression correlates with angiogenesis and apoptosis in gastric cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15156115&form=6&db=m [Role of cyclooxygenase-2 (COX-2) and peroxisome proliferator-activated receptor (PPAR) in gastric cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15222049&form=6&db=m Anti-cancer effects of COX-2 inhibitors and their correlation with angiogenesis and invasion in gastric cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15245777&form=6&db=m Molecular biology of sporadic gastric cancer: prognostic indicators and novel therapeutic approaches. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15298601&form=6&db=m Sex differences in mucosal response to Helicobacter pylori infection in the stomach and variations in interleukin-8, COX-2 and trefoil factor family 1 gene expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15309882&form=6&db=m Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15312381&form=6&db=m [Nimesulide, a selective cyclooxygenase-2 inhibitor inhibits telomerase activity by blocking activation of PKB in gastric cancer cell line] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15319299&form=6&db=m Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15332534&form=6&db=m [COX and study of cancer therapy] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15334675&form=6&db=m Roles of Helicobacter pylori infection and cyclooxygenase-2 expression in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15382074&form=6&db=m Enhanced inhibitive effects of combination of rofecoxib and octreotide on the growth of human gastric cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501972&form=6&db=m Concomitant overexpression of cyclooxygenase-2 in HER-2-positive on Smad4-reduced human gastric carcinomas is associated with a poor patient outcome. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15532792&form=6&db=m Overexpression of cyclooxygenase-2 and tumor angiogenesis in human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15585646&form=6&db=m the selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15601550&form=6&db=m [Inhibitory effects of celecoxib combined with octreotide on growth of multidrug resistant human gastric cancer cell line SGC7901/ADR.] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15622477&form=6&db=m Correlation between cyclooxygenase-2, proliferative activity, and mucin phenotype in human advanced gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15634545&form=6&db=m [The role of cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of gastric cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15692787&form=6&db=m Promoter-controlled infectivity-enhanced conditionally replicative adenoviral vectors for the treatment of gastric cancer. therapeutic application,unassigned 2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15754411&form=6&db=m Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15793875&form=6&db=m Apoptosis of human gastric cancer SGC-7901 cells induced by mitomycin combined with sulindac. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15812154&form=6&db=m Chemoprevention of gastric cancer: role of COX-2 inhibitors and other agents. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15890232&form=6&db=m Expression of peroxisome proliferator-activated receptor delta in human gastric cancer and its response to specific COX-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15914275&form=6&db=m Inhibition of gastric cancer-associated angiogenesis by antisense COX-2 transfectants. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15929167&form=6&db=m Helicobacter pylori promote gastric cancer cells invasion through a NF-kappaB and COX-2-mediated pathway. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15929174&form=6&db=m Mechanism and clinical significance of cyclooxygenase-2 expression in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15946562&form=6&db=m [Mechanism of apoptosis induced by specific COX-2 inhibitor SC236 in gastric cancer cells] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15949425&form=6&db=m [COX-2 expression in the H. pylori infected gastric mucosal epithelia and its significance] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15995627&form=6&db=m PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16009342&form=6&db=m Inhibitory effect of etodolac, a selective cyclooxygenase-2 inhibitor, on stomach carcinogenesis in Helicobacter pylori-infected Mongolian gerbils. causal interaction,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16053517&form=6&db=m Inhibitory effect of a selective cyclooxygenase inhibitor on the invasion-stimulating activity of orthotopic fibroblasts for scirrhous gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16054988&form=6&db=m Nicotine and gastric cancer. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16082585&form=6&db=m Elevated cyclooxygenase-2 expression in patients with early gastric cancer in the gastric pylorus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16097070&form=6&db=m Expression of cyclooxygenase-2 in gastric cancer and its relation to liver metastasis and long-term prognosis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16097073&form=6&db=m Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16101131&form=6&db=m Increased expression of interleukin-1alpha and cyclooxygenase-2 in human gastric cancer: a possible role in tumor progression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16115920&form=6&db=m Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-kappaB/cyclooxygenase-2 signaling pathway. causal interaction,unassigned 3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136511&form=6&db=m COX-2 overexpression in canine tumors: potential therapeutic targets in oncology. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167259&form=6&db=m [Relationship between cyclooxygenase- 2 expression and angiogenesis in patients with gastric cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16167260&form=6&db=m [COX- 2 expression in gastric cancer and its relationship with lymphangiogenesis and lymph node metastasis] causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243430&form=6&db=m Effects of COX-2 inhibitor on growth of human gastric cancer cells and its relation to hepatocyte growth factor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16243808&form=6&db=m Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16254046&form=6&db=m Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16260857&form=6&db=m Overexpression of cyclooxygenase-2 in gastric cancer correlates with the high abundance of vascular endothelial growth factor-C and lymphatic metastasis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16314343&form=6&db=m Expression of cyclooxygenase-2 and matrix metalloproteinase-9 in gastric carcinoma and its correlation with angiogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16317086&form=6&db=m Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer. causal interaction,unassigned 3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16338068&form=6&db=m Celecoxib could reverse the hypoxia-induced Angiopoietin-2 upregulation in gastric cancer. ongoing research,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16339564&form=6&db=m Helicobacter pylori-Induced invasion and angiogenesis of gastric cells is mediated by cyclooxygenase-2 induction through TLR2/TLR9 and promoter regulation. therapeutic application,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16371352&form=6&db=m Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16394872&form=6&db=m Preferential expression of cyclooxygenase-2 in colonic-phenotype of gastric intestinal metaplasia: association with helicobacter pylori and gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16448745&form=6&db=m A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16474375&form=6&db=m Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507394&form=6&db=m Cyclooxygenase-2 expression is associated with VEGF-C and lymph node metastases in gastric cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507395&form=6&db=m Cyclooxygenase-2 inhibitors suppress angiogenesis and growth of gastric cancer xenografts. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16613675&form=6&db=m [Mechanisms of Inhibiting Proliferation and Inducing Apoptosis of Human Gastric Cancer Cell Line SGC7901 by Ursolic Acid.] diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16641552&form=6&db=m Inhibition of Akt/PKB by a COX-2 inhibitor induces apoptosis in gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677165&form=6&db=m Influences of Helicobacter pylori on cyclooxygenase-2 expression and prostaglandinE2 synthesis in rat gastric epithelial cells in vitro. causal interaction,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677505&form=6&db=m [Effects of gastrin receptor antagonist and cyclooxygenase-2 inhibitor on proliferation and apoptosis of gastric cancer cell] diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677508&form=6&db=m [Effects of inhibition of cyclooxygenase-2 by RNA interference on proliferation and apoptosis of human gastric cancer cells: an experimental study with human gastric cancer cells and mice] causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16718813&form=6&db=m Non-steroidal anti-inflammatory drugs in prevention of gastric cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16731602&form=6&db=m MMP-2 but not MMP-9 associated with COX-2 and survival in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16733888&form=6&db=m [Genetic polymorphisms in the promoter region of cyclooxygenase-2 and their association with risk of gastric cancer] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16760271&form=6&db=m Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762620&form=6&db=m Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese population. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16762640&form=6&db=m COX-2 and gastric cancer: More on inflammation and neoplasia. ongoing research,unassigned 3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16808793&form=6&db=m Chemopreventive effects of rofecoxib and folic acid on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16825903&form=6&db=m Chemoprevention of gastric cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16899628&form=6&db=m Effects of long-term rofecoxib on gastric intestinal metaplasia: results of a randomized controlled trial. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16900533&form=6&db=m Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949912&form=6&db=m Infrequent COX-2 expression due to promoter hypermethylation in gastric cancers in Dalian, China. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17003101&form=6&db=m Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17031478&form=6&db=m DNA repair Ku proteins in gastric cancer cells and pancreatic acinar cells. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17043422&form=6&db=m Expression of cyclooxygenase-2, p53 and Ki-67 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17074152&form=6&db=m [Expression of tissue microarray p53, p16 and cyclooxygenase-2 in gastric cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17096355&form=6&db=m Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17118848&form=6&db=m Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17147112&form=6&db=m [Inhibition of gastric cancer cells growth in vitro by sulindac] causal interaction,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17171787&form=6&db=m Microvessel density is a prognostic marker of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17199977&form=6&db=m [Expression of peroxisome proliferators-activated receptor-gamma and cyclooxygenase-2 in Helicobacter pylori infection-associated diseases and significance thereof] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17224647&form=6&db=m Effect of celecoxib on E-cadherin, VEGF, Microvessel density and apoptosis in gastric cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17257745&form=6&db=m Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17313803&form=6&db=m [The inhibitive effects of celecoxib combined with octreotide on the metastasis of human gastric cancer in vivo] diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17323186&form=6&db=m Chemopreventive effect of celecoxib in gastric cancer. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17341851&form=6&db=m COX-2 inhibition and the prevention of gastric cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17341852&form=6&db=m Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17374440&form=6&db=m Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17393325&form=6&db=m The anti-cancer effect of COX-2 inhibitors on gastric cancer cells. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17649633&form=6&db=m [Antitumor effects of specific cyclooxygenase inhibitors combined with chemotherapeutic agents on gastric cancer cells in vitro] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17659693&form=6&db=m COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarray. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17785115&form=6&db=m [The potential role of Id1 in COX-2 mediated angiogenesis in gastric cancer] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17868774&form=6&db=m Clinical significance of prostaglandin E synthase expression in gastric cancer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17959037&form=6&db=m Preoperative growth inhibition of human gastric adenocarcinoma treated with a combination of celecoxib and octreotide. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971580&form=6&db=m Thinking in and out of the box when it comes to gastric cancer and cyclooxygenase-2. ongoing research,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17971584&form=6&db=m Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17982644&form=6&db=m Targeted inhibition of COX-2 expression by RNA interference suppresses tumor growth and potentiates chemosensitivity to cisplatin in human gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18068001&form=6&db=m Expression of cyclooxygenase-2 and vascular endothelial growth factor-C correlates with lymphangiogenesis and lymphatic invasion in human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18174234&form=6&db=m Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18181047&form=6&db=m Positive correlation of osteopontin, cyclooxygenase-2 and vascular endothelial growth factor in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18258354&form=6&db=m Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18311113&form=6&db=m The COX-2 promoter polymorphism -765 G>C is associated with early-onset, conventional and stump gastric cancers. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18373164&form=6&db=m Monocyte chemoattractant protein 1 and CD40 ligation have a synergistic effect on vascular endothelial growth factor production through cyclooxygenase 2 upregulation in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18462890&form=6&db=m Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18466392&form=6&db=m The effects of cyclooxygenase2-prostaglandinE2 pathway on Helicobacter pylori-induced urokinase-type plasminogen activator system in the gastric cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18570890&form=6&db=m Constitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18611916&form=6&db=m Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18618313&form=6&db=m Lactobacillus acidophilus 74-2 and butyrate induce cyclooxygenase (COX)-1 expression in gastric cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18683800&form=6&db=m [The effect of siRNA on inhibiting cyclooxygenase-2 gene expression in gastric adenocarcinoma cell] causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18758643&form=6&db=m Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18775915&form=6&db=m Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18805435&form=6&db=m Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathways. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18923901&form=6&db=m Anticancer Effect of Celecoxib via COX-2 Dependent and Independent Mechanisms in Human Gastric Cancers Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18985541&form=6&db=m Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18987470&form=6&db=m Celecoxib inhibits apurinic/apyrimidinic endonuclease-1 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19024521&form=6&db=m [Celecoxib induces apoptosis and inhibites angiogenesis in gastric cancer] diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19107602&form=6&db=m Expression of COX-2 in Stomach Carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19141979&form=6&db=m [Effect of a selective COX-2 inhibitor on cell proliferation and apoptosis in human gastric cancer cell line BGC-823] diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19159555&form=6&db=m [Expression of cyclooxygenase-2 and urokinase plasminogen activator in gastric carcinoma and the clinical significance thereof] causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19173907&form=6&db=m [Correlation of Helicobacter pylori infection with the expression of COX-2 and EGFR and VEGF in human gastric carcinoma] causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19196394&form=6&db=m Molecular basis of therapeutic approaches to gastric cancer. causal interaction,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19201083&form=6&db=m Helicobacter pylori enhances cyclooxygenase 2 expression via p38MAPK/ATF-2 signaling pathway in MKN45 cells. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19418489&form=6&db=m Association between color doppler vascularity index, angiogenesis-related molecules, and clinical outcomes in gastric cancer. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19463183&form=6&db=m Polymorphism in COX-2 modifies the inverse association between Helicobacter pylori seropositivity and esophageal squamous cell carcinoma risk in Taiwan: a case control study. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19491270&form=6&db=m The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19661089&form=6&db=m Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19846662&form=6&db=m MBP-1 Suppresses Growth and Metastasis of Gastric Cancer Cells through COX-2. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19916560&form=6&db=m R-flurbiprofen reverses multidrug resistance, proliferation and metastasis in gastric cancer cells by p75(NTR) induction. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19940363&form=6&db=m Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric cancer cell lines. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20026064&form=6&db=m Prostaglandin E2 prevents Helicobacter-induced gastric preneoplasia and facilitates persistent infection in a mouse model. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20082476&form=6&db=m Helicobacter pylori and EBV in gastric carcinomas: methylation status and microsatellite instability. causal interaction,unassigned 2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20132429&form=6&db=m Rofecoxib augments anticancer effects by reversing intrinsic multidrug resistance gene expression in BGC-823 gastric cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20210736&form=6&db=m The effects of radix curcumae extract on expressions of VEGF, COX-2 and PCNA in gastric mucosa of rats fed with MNNG. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20237896&form=6&db=m COX-2 is associated with proliferation and apoptosis markers and serves as an independent prognostic factor in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20364406&form=6&db=m Study on the association of COX-2 genetic polymorphisms with risk of gastric cancer in high incidence Hexi area of Gansu province in China. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20446925&form=6&db=m The value of MG7-Ag and COX-2 for predicting malignancy in gastric precancerous lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20649594&form=6&db=m Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20699658&form=6&db=m 15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20712078&form=6&db=m MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20939988&form=6&db=m [Chinese herbal medicine Jianpi Jiedu Formula down-regulates the expression of vascular endothelial growth factor in human gastric cell line MKN45 induced by Helicobacter pylori by inhibiting cyclooxygenase-2.] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20944126&form=6&db=m KITENIN is associated with tumor progression in human gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20965124&form=6&db=m MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion. causal interaction,ongoing research,unassigned 3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21081469&form=6&db=m NF-?B targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21266034&form=6&db=m The function and mechanism of COX-2 in angiogenesis of gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21272377&form=6&db=m Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,4,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21275453&form=6&db=m A new cyclo-oxygenase-2 gene variant in the Han Chinese population is associated with an increased risk of gastric carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479450&form=6&db=m A polymorphism in the 3'-utr of cyclooxygenase-2 and the risk of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21488197&form=6&db=m Effect of pertussis toxin and herbimycin A on proteinase-activated receptor 2-mediated cyclooxygenase 2 expression in Helicobacter pylori-infected gastric epithelial AGS cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21494638&form=6&db=m Wnt/?-catenin signaling enhances cyclooxygenase-2 (COX2) transcriptional activity in gastric cancer cells. causal interaction,unassigned 3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21538574&form=6&db=m Interaction of Cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21540248&form=6&db=m Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. ongoing research,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21812267&form=6&db=m [Effect of jianpi jiedu recipe on microvessel density and cyclooxygenm-2 expression in Heliobacter pylori induced gastric cancer]. ongoing research,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21830126&form=6&db=m Cycloxygenase-2 is Essential for the Survival and Proliferation of Gastric Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21849808&form=6&db=m Inactivation of COX-2, HMLH1 and CDKN2A Gene by Promoter Methylation in Gastric Cancer: Relationship with Histological Subtype, Tumor Location and Helicobacter pylori Genotype. causal interaction,diagnostic usage,ongoing research,unassigned 2,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21866663&form=6&db=m [Jianpi jiedu recipe inhibited Helicobacter pylori-induced the expression of cyclooxygenase-2 via p38MAPK/ATF-2 signal transduction pathway in human gastric cancer cells]. ongoing research,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21976141&form=6&db=m Notch2-induced COX-2 expression enhancing gastric cancer progression. causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22002749&form=6&db=m Cyclooxygenase-2 and gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22034055&form=6&db=m Inhibition of cyclooxygenase-2 causes regression of gastric adenomas in trefoil factor 1 deficient mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22048943&form=6&db=m Prognostic significance of cyclooxygenase-2, epidermal growth factor receptor 1, and microvascular density in gastric cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22289529&form=6&db=m Involvement of nuclear factor ?B (NF-?B) in the downregulation of cyclooxygenase-2 (COX-2) by genistein in gastric cancer cells. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22385256&form=6&db=m A Genetic Variant in 3'-Untranslated Region of Cyclooxygenases-2 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22549391&form=6&db=m Tumor interstitial fluid and gastric cancer metastasis: an experimental study to verify the hypothesis of "tumor-phlegm microenvironment". ongoing research,unassigned 2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22582975&form=6&db=m The influence of transforming growth factor-?, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22610150&form=6&db=m Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22740864&form=6&db=m Cyclooxygenase-2 polymorphisms and the risk of gastric cancer in various degrees of relationship in the Chinese Han population. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22764438&form=6&db=m Evaluation of specific biochemical indicators of Helicobacter pylori-associated gastric cancer in Egypt. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22844559&form=6&db=m The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22848259&form=6&db=m Sinomenine inhibits proliferation of SGC-7901 gastric adenocarcinoma cells via suppression of cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22929309&form=6&db=m Epstein-barr virus infected gastric adenocarcinoma expresses latent and lytic viral transcripts and has a distinct human gene expression profile. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22941376&form=6&db=m Protease-activated receptor-2 induces expression of vascular endothelial growth factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23001726&form=6&db=m The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23013439&form=6&db=m Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23052170&form=6&db=m Heterogeneity of COX-2 and multidrug resistance between primary tumors and regional lymph node metastases of gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23161322&form=6&db=m Assessment of COX-2 expression presence and severity by immunohistochemical method in patients with chronic active gastritis and intestinal metaplasia. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23194884&form=6&db=m Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2). causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23307260&form=6&db=m Reduced group IVA phospholipase A2 expression is associated with unfavorable outcome for patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376640&form=6&db=m Gastrin acting on the cholecystokinin2 receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K/Akt pathway in human gastric cancer cells. causal interaction,ongoing research,unassigned 2,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23534741&form=6&db=m Diet folate, DNA methylation and polymorphisms in methylenetetrahydrofolate reductase in association with the susceptibility to gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23574384&form=6&db=m Celecoxib Inhibits Helicobacter pylori-induced Invasion of Gastric Cancer Cells Through an Adenine Nucleotide Translocator-Dependent Mechanism. ongoing research,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23593346&form=6&db=m Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23644120&form=6&db=m [Expressions of COX-2, PKC-? and miR-101 in gastric cancer and their correlations]. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23670240&form=6&db=m COX-2 regulates E-cadherin expression through the NF-?B/Snail signaling pathway in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23775011&form=6&db=m Cyclooxygenase-2 polymorphisms were associated with the risk of gastric cancer: evidence from a meta-analysis based on case-control studies. diagnostic usage,ongoing research,unassigned 4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24037722&form=6&db=m COX-2, TFF1, and Src define better prognosis in young patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,2,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24115825&form=6&db=m Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24127267&form=6&db=m A positive feedback loop between STAT3 and cyclooxygenase-2 gene may contribute to Helicobacter pylori-associated human gastric tumorigenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24176842&form=6&db=m Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24178897&form=6&db=m Cyclooxygenase-2 expression is associated with poor overall survival of patients with gastric cancer: a meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24233024&form=6&db=m Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24259966&form=6&db=m Role of cyclooxygenase-2 in gastric cancer development and progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24533777&form=6&db=m The Role of Anti-LeY Antibody in the Downregulation of MAPKs/COX-2 Pathway in Gastric Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24616567&form=6&db=m MicroRNA-143 suppresses gastric cancer cell growth and induces apoptosis by targeting COX-2. therapeutic application,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649093&form=6&db=m Effect of celecoxib plus standard chemotherapy on serum levels of vascular endothelial growth factor and cyclooxygenase-2 in patients with gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24761915&form=6&db=m The 765G>C polymorphism in the cyclooxygenase-2 gene and gastric cancer risk: an update by meta-analysis. ongoing research,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24796667&form=6&db=m PLC?1: a potential target of RNA interference therapy for gastric cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25003256&form=6&db=m -765 g>c polymorphism of the cox-2 gene and gastric cancer risk in Brazilian population. ongoing research,unassigned 3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25077681&form=6&db=m Pseudolaric acid B circumvents multidrug resistance phenotype in human gastric cancer SGC7901/ADR cells by downregulating Cox-2 and P-gp expression. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25246284&form=6&db=m The mechanism of COX-2 regulating HERG channel in gastric cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25278683&form=6&db=m Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25371669&form=6&db=m COX-2 Inhibitors and Gastric Cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25881460&form=6&db=m [Effect of jianpi tongluo jiedu recipe on expression levels of COX-2, NF-kappaBp65, and Bcl-2 in gastric mucosa of patients with precancerous lesions of gastric cancer]. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25921160&form=6&db=m Sensitivity of gastric cancer cells to chemotherapy drugs in elderly patients and its correlation with cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25945055&form=6&db=m Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26391267&form=6&db=m Population, Epidemiological, and Functional Genetics of Gastric Cancer Candidate Genes in Peruvians with Predominant Amerindian Ancestry. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26407653&form=6&db=m Celecoxib enhanced the cytotoxic effect of cisplatin in drug-resistant human gastric cancer cells by inhibition of cyclooxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26514342&form=6&db=m Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBP? and NF?B cleavage. therapeutic application,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26550156&form=6&db=m Cyclooxygenase-2 -1195G>A (rs689466) polymorphism and cancer susceptibility: an updated meta-analysis involving 50,672 subjects. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26604791&form=6&db=m miR-21 inhibits the effects of cyclooxygenase-2 inhibitor NS398 on apoptosis and invasion in gastric cancer cells. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622726&form=6&db=m Paclitaxel combined with harmine inhibits the migration and invasion of gastric cancer cells through downregulation of cyclooxygenase-2 expression. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26674784&form=6&db=m Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,2,2
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27020655&form=6&db=m Alterations of cyclooxygenase-2 methylation levels before and after intervention trial to prevent gastric cancer in a Chinese population. therapeutic application,unassigned 2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27079437&form=6&db=m Inflammation in gastric cancer: Interplay of the COX-2/prostaglandin E2 and Toll-like receptor/MyD88 pathways. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27198692&form=6&db=m Helicobacter pylori promotes angiogenesis depending on Wnt/beta-catenin-mediated vascular endothelial growth factor via the cyclooxygenase-2 pathway in gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27232941&form=6&db=m JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27314294&form=6&db=m Clinical and prognosis relevance of COX-2 expression in Tunisian patients with primary gastric adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27352184&form=6&db=m Detection and Clinical Significance of COX-2 Gene SNPs in Gastric Cancer. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27377703&form=6&db=m Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27446381&form=6&db=m Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27457107&form=6&db=m Prognostic significance of expression of cysteine-rich 61 and cyclooxygenase-2 in gastric cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27802436&form=6&db=m WIN 55,212-2 Inhibits the Epithelial Mesenchymal Transition of Gastric Cancer Cells via COX-2 Signals. ongoing research,unassigned 3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28105626&form=6&db=m [Effect of polyunsaturated fatty acids ?-3 and ?-6 on angiogenesis formation in human gastric cancer]. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28405152&form=6&db=m Association between COX-2 -1195G>A polymorphism and gastrointestinal cancer risk: A meta-analysis. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28586004&form=6&db=m COX-2 regulates Snail expression in gastric cancer via the Notch1 signaling pathway. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28624843&form=6&db=m Expressions of Ras Homolog Gene Family, Member A (RhoA) and Cyclooxygenase-2 (COX-2) Proteins in Early Gastric Cancer and Their Role in the Development of Gastric Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,2,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28769030&form=6&db=m miR-30a acts as a tumor suppressor by double-targeting COX-2 and BCL9 in H. pylori gastric cancer models. therapeutic application,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29151957&form=6&db=m Curcumin Enhances the Anticancer Effect Of 5-fluorouracil against Gastric Cancer through Down-Regulation of COX-2 and NF- ?B Signaling Pathways. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29190954&form=6&db=m Cyclooxygenase-2 mediated synergistic effect of ursolic acid in combination with paclitaxel against human gastric carcinoma. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29254791&form=6&db=m Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29390421&form=6&db=m Comprehensive evaluation of clinical efficacy and safety of celecoxib combined with chemotherapy in management of gastric cancer. diagnostic usage,therapeutic application,unassigned 1,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29456712&form=6&db=m MicroRNA-144 functions as a tumor suppressor in gastric cancer by targeting cyclooxygenase-2. therapeutic application,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29636598&form=6&db=m The role of propranolol as a radiosensitizer in gastric cancer treatment. causal interaction,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29901169&form=6&db=m ?-tocotrienol inhibits the invasion and migration of human gastric cancer cells through downregulation of cyclooxygenase-2 expression. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29942193&form=6&db=m The role of bile acids in cellular invasiveness of gastric cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30003735&form=6&db=m Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30391440&form=6&db=m Roles of Cyclooxygenase-2 gene -765G?>?C (rs20417) and -1195G?>?A (rs689466) polymorphisms in gastric cancer: A systematic review and meta-analysis. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30941969&form=6&db=m Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31045826&form=6&db=m Association between rs20417 polymorphism in cyclooxygenase-2 and gastric cancer susceptibility: Evidence from15 case-control studies. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31277138&form=6&db=m A comprehensive evaluation of clinical efficacy and safety of celecoxib in combination with chemotherapy in metastatic or postoperative recurrent gastric cancer patients: A preliminary, three-center, clinical trial study. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31297043&form=6&db=m Ethanol extracts of Allium sp. regulate cyclooxygenase-2 and E-cadherin expression in gastric cancer MKN74 cell line and enhance doxorubicin toxicity. ongoing research,unassigned 3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31313480&form=6&db=m Phthalate plasticizer di(2-ethyl-hexyl) phthalate induces cyclooxygenase-2 expression in gastric adenocarcinoma cells. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31473273&form=6&db=m EBV down-regulates COX-2 expression via TRAF2 and ERK signal pathway in EBV-associated gastric cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31491956&form=6&db=m Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31518663&form=6&db=m Cisplatin induces chemoresistance through the PTGS2-mediated anti-apoptosis in gastric cancer. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31792089&form=6&db=m Statins Were Associated with a Reduced Gastric Cancer Risk in Patients with Eradicated Helicobacter Pylori Infection: A Territory-Wide Propensity Score Matched Study. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32175764&form=6&db=m COX-2 promotes metastasis and predicts prognosis on gastric cancer via regulating mTOR. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32364228&form=6&db=m Myrrh induces the apoptosis and inhibits the proliferation and migration of gastric cancer cells through down-regulating cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,1
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32603043&form=6&db=m Relation of cyclooxygenase-2 expression with premalignant gastric lesions. causal interaction,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33132637&form=6&db=m Acetyl-11-keto-?-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33440718&form=6&db=m Genetic Variations in Prostaglandin E2 Pathway Identified as Susceptibility Biomarkers for Gastric Cancer in an Intermediate Risk European Country. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33489855&form=6&db=m Celecoxib induces apoptosis through Akt inhibition in 5-fluorouracil-resistant gastric cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33741381&form=6&db=m Preparation of novel anthraquinone-based aspirin derivatives with anti-cancer activity. causal interaction,unassigned 1,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34122616&form=6&db=m Ghrelin Regulates Cyclooxygenase-2 Expression and Promotes Gastric Cancer Cell Progression. unassigned -
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34263071&form=6&db=m Nonsteroidal anti-inflammatory drugs prevent gastric cancer associated with the use of proton pump inhibitors after Helicobacter pylori eradication. therapeutic application,unassigned 2,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34366627&form=6&db=m Genetic variant of cyclooxygenase-2 in gastric cancer: More inflammation and susceptibility. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34396632&form=6&db=m Long noncoding RNA NEAT1 promotes tumorigenesis in H. pylori gastric cancer by sponging miR-30a to regulate COX-2/BCL9 pathway. unassigned -
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=415531&form=6&db=m Aspirin and ulcers. causal interaction,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9253772&form=6&db=m [Multiple roles of inducible cyclooxygenase-2 and its selective inhibitors] therapeutic application,unassigned 1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9521828&form=6&db=m Levels of cyclooxygenase-1 and -2 mRNA expression at various stages of acute gastric injury induced by ischemia-reperfusion in rats. causal interaction,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9535006&form=6&db=m Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,3
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9732401&form=6&db=m Role of cyclooxygenase-2 in the healing of gastric ulcers in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9765350&form=6&db=m Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9815044&form=6&db=m Localization of cyclooxygenase-2 and regulation of its mRNA expression in gastric ulcers in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9856140&form=6&db=m [Non-steroidal anti-inflammatory agents (NSAID's) with lesser side effects by selective inhibition of cyclo-oxygenase-2] therapeutic application,unassigned 2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10069692&form=6&db=m Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses. therapeutic application,unassigned 2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10390127&form=6&db=m Cyclooxygenase-2 specificity and its clinical implications. diagnostic usage,therapeutic application,unassigned 1,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10486360&form=6&db=m Expression of cyclooxygenase 1 and 2 by human gastric endothelial cells. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10525082&form=6&db=m Regulation by endogenous interleukin-1 of mRNA expression of healing-related factors in gastric ulcers in rats. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10667325&form=6&db=m Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10801275&form=6&db=m Cyclooxygenase-1 and an alternatively spliced mRNA in the rat stomach: effects of aging and ulcers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807402&form=6&db=m The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts. ongoing research,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10807888&form=6&db=m Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11028754&form=6&db=m Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11093953&form=6&db=m Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11136275&form=6&db=m Up-regulation of cyclooxygenase-1 and -2 in human gastric ulcer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11142556&form=6&db=m Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs. therapeutic application,unassigned 3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11192947&form=6&db=m Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11376495&form=6&db=m Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11433182&form=6&db=m Comparison of nitric oxide-releasing NSAID and vitamin C with classic NSAID in healing of chronic gastric ulcers; involvement of reactive oxygen species. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11508687&form=6&db=m Lack of gastric toxicity of nitric oxide-releasing indomethacin, NCX-530, in experimental animals. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11511570&form=6&db=m Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11519793&form=6&db=m Implication of gastrin in cyclooxygenase-2 expression in Helicobacter pylori infected gastric ulceration. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11549833&form=6&db=m Effect of local application of growth factors on gastric ulcer healing and mucosal expression of cyclooxygenase-1 and -2. causal interaction,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595412&form=6&db=m Role of cyclooxygenase isoforms in gastric mucosal defence. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11595463&form=6&db=m NSAIDs inhibit the activation of egr-1 gene in microvascular endothelial cells. A key to inhibition of angiogenesis? therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745453&form=6&db=m Is COX-2 inhibition a panacea for cancer prevention? causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11758826&form=6&db=m Role of cyclooxygenase-2 in gastric mucosal defense. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11854834&form=6&db=m The Role of Cyclooxygenase-2 in Inflammation. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11891194&form=6&db=m Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11930633&form=6&db=m [Effects of cyclooxygenase-2 on formation and healing of acetic acid-induced gastric ulcer in rats] causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12020690&form=6&db=m Chronic gastric ulcer healing in rats subjected to selective and non-selective cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12070271&form=6&db=m Induction of cyclo-oxygenase-2 expression in naturally occurring gastric ulcers. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12217640&form=6&db=m Antiangiogenic effect of a highly selective cyclooxygenase-2 inhibitor on gastric ulcer healing in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12232050&form=6&db=m Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12678329&form=6&db=m Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12853723&form=6&db=m Interaction of hepatocyte growth factor and non-steroidal anti-inflammatory drugs during gastric epithelial wound healing. causal interaction,unassigned 2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12871756&form=6&db=m Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12918117&form=6&db=m Expression and activities of three inducible enzymes in the healing of gastric ulcers in rats. causal interaction,diagnostic usage,unassigned 2,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529401&form=6&db=m Mucosal repair and COX-2 inhibition. causal interaction,unassigned 3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14529402&form=6&db=m COX-2 inhibition, H. pylori infection and the risk of gastrointestinal complications. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14642793&form=6&db=m Impaired gastric ulcer healing in diabetic rats: role of heat shock protein, growth factors, prostaglandins and proinflammatory cytokines. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15025185&form=6&db=m Effects of Rumex patientia root extract on indomethacine and ethanol induced gastric damage in rats. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15035806&form=6&db=m Differential role of platelet-activating factor in gastric mucosal ulcer healing. therapeutic application,unassigned 2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15075467&form=6&db=m Experimental production of peptic ulcer, gastric damage and cancer models and their use in pathophysiological studies and pharmacological treatment - Polish achievements. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15213313&form=6&db=m Reducing clinically significant gastrointestinal toxicity associated with nonsteroidal antiinflammatory drugs. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15246970&form=6&db=m Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15531909&form=6&db=m Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15556152&form=6&db=m Angiogenesis, cell proliferation and apoptosis in gastric ulcer healing. Effect of a selective cox-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15599211&form=6&db=m The interaction of H. pylori infection and NSAIDs in cyclooxygenase-2 mRNA expression in gastric antral, corpus mucosa, and gastric ulcer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15613743&form=6&db=m Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 2,2,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15652766&form=6&db=m COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions. causal interaction,unassigned 2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15720413&form=6&db=m Mucosal expression of cyclooxygenase isoforms 1 and 2 is increased with worsening damage to the gastric mucosa. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139265&form=6&db=m Cyclo-oxygenase-2 expression and prostaglandin E2 production in experimental chronic gastric ulcer healing. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16184416&form=6&db=m The role of cyclooxygenase in gastric mucosal protection. causal interaction,unassigned 3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16200780&form=6&db=m [Expression and activity of cyclooxygenases-1 and -2 in acetic acid induced gastric ulcer in rats] diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16259725&form=6&db=m Role of cyclooxygenase isoforms in gastric mucosal defense and ulcer healing. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16357062&form=6&db=m Heregulin-alpha and heregulin-beta expression is linked to a COX-2-PGE2 pathway in human gastric fibroblasts. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16373427&form=6&db=m Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16375889&form=6&db=m Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis: towards a better non-steroidal anti-inflammatory drug. unassigned -
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16600210&form=6&db=m Differential effects of selective and non-selective inhibition of nitric oxide synthase on the expression and activity of cyclooxygenase-2 during gastric ulcer healing. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17086892&form=6&db=m Influence of COX-2 and local cytokine expressions in gastric ulcer mucosa by H. pylori and NSAID. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,3,1
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17233075&form=6&db=m Melatonin in gastroprotection against stress-induced acute gastric lesions and in healing of chronic gastric ulcers. causal interaction,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17380018&form=6&db=m Gastric mucosal levels of prostaglandins and leukotrienes in patients with gastric ulcer after treatment with rabeprazole in comparison to treatment with ranitidine. unassigned -
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17392162&form=6&db=m Novel roles of local insulin-like growth factor-1 activation in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a phosphatidylinositol 3-kinase-dependent manner. causal interaction,unassigned 1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17666341&form=6&db=m [Selective COX-2 inhibitor delays experimental gastric ulcer healing by stimulating gastric acid secretion in rats] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,2
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671743&form=6&db=m Association between genetic polymorphisms in the cyclooxygenase-1 gene promoter and peptic ulcers in Japan. causal interaction,diagnostic usage,unassigned 3,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17673547&form=6&db=m Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17926530&form=6&db=m [The choice of selective COX-2 inhibitors] therapeutic application,unassigned 2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17926535&form=6&db=m [The role of mucoprotective drugs in a treatment and prevention for NSAID-induced gastric ulcer] unassigned -
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18452178&form=6&db=m Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation. therapeutic application,unassigned 3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18812628&form=6&db=m Tryptophan free diet delays healing of chronic gastric ulcers in rat. ongoing research,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19041231&form=6&db=m Mechanism of action of celecoxib on normal and acid-challenged gastric mucosa. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20433387&form=6&db=m Expression of cyclooxygenase isoforms in ulcerated tissues of the nonglandular portion of the stomach in horses. therapeutic application,unassigned 1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20813913&form=6&db=m Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20814070&form=6&db=m Gastric ulcer healing and stress-lesion preventive properties of pioglitazone are attenuated in diabetic rats. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22495067&form=6&db=m Nonsteroidal anti-inflammatory drug-activated gene-1 plays a role in the impairing effects of cyclooxygenase inhibitors on gastric ulcer healing. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22626975&form=6&db=m Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation. unassigned -
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24622834&form=6&db=m Involvement of cyclooxygenase-1 and cyclooxygenase-2 activity in the therapeutic effect of ghrelin in the course of ethanol-induced gastric ulcers in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25875506&form=6&db=m In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isoliquiritigenin in mice. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27916468&form=6&db=m Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile. therapeutic application,unassigned 2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27942290&form=6&db=m Recombinant Human Epidermal Growth Factor Alleviates Gastric Antral Ulcer Induced by Naproxen: A Non-steroidal Anti Inflammatory Drug. unassigned -
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28011266&form=6&db=m Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28322956&form=6&db=m Polysaccharide of Black cumin (Nigella sativa) modulates molecular signaling cascade of gastric ulcer pathogenesis. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28342204&form=6&db=m The EP4 antagonist, L-161,982, induces apoptosis, cell cycle arrest and inhibits prostaglandin E2 induced proliferation in oral squamous carcinoma Tca8113 cells. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28539709&form=6&db=m Multipathway Integrated Adjustment Mechanism of Glycyrrhiza Triterpenes Curing Gastric Ulcer in Rats. diagnostic usage,unassigned 3,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29076755&form=6&db=m Discovery of a COX-2 selective inhibitor hit with anti-inflammatory activity and gastric ulcer protective effect. therapeutic application,unassigned 4,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29397336&form=6&db=m Artesunate affords protection against aspirin-induced gastric injury by targeting oxidative stress and proinflammatory signaling. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29433672&form=6&db=m Protective role of ?-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29956615&form=6&db=m Roles of Cyclooxygenase, Prostaglandin E2 and EP Receptors in Mucosal Protection and Ulcer Healing in the Gastrointestinal Tract. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396089&form=6&db=m Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. ongoing research,unassigned 1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30530291&form=6&db=m Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-?, NF-?B, and COX-2 levels, and upregulation of TFF-2 levels. diagnostic usage,ongoing research,unassigned 4,1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31111367&form=6&db=m Induction of COX-1, suppression of COX-2 and pro-inflammatory cytokines gene expression by moringa leaves and its aqueous extract in aspirin-induced gastric ulcer rats. ongoing research,unassigned 2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31611922&form=6&db=m Anti-Inflammatory Effects of Licania macrocarpa Cuatrec Methanol Extract Target Src- and TAK1-Mediated Pathways. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31979417&form=6&db=m Chrysin Modulates Genes Related to Inflammation, Tissue Remodeling, and Cell Proliferation in the Gastric Ulcer Healing. causal interaction,unassigned 1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32204312&form=6&db=m Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats. causal interaction,unassigned 1,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32800836&form=6&db=m Attenuation of ischemia-reperfusion-induced gastric ulcer by low-dose vanadium in male Wistar rats. ongoing research,unassigned 2,0
1.14.99.1 Stomach Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33354210&form=6&db=m Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats. ongoing research,unassigned 2,0
1.14.99.1 Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14693241&form=6&db=m The relationship between mucosal cyclooxygenase-2 (COX-2) expression and experimental radiation-induced mucositis. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16099597&form=6&db=m Nuclear factor kappaB (NFkappaB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes. unassigned -
1.14.99.1 Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17885826&form=6&db=m Spatio-temporal localization of HIF-1alpha and COX-2 during irradiation-induced oral mucositis in a rat model system. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,4,0
1.14.99.1 Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19234862&form=6&db=m Cyclooxygenase-2 and vascular endothelial growth factor expression in 5-fluorouracil-induced oral mucositis in hamsters: evaluation of two low-intensity laser protocols. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,3,0
1.14.99.1 Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19404685&form=6&db=m Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,3,2
1.14.99.1 Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24652604&form=6&db=m Double-blind, placebo-controlled, randomized phase II study of TJ-14 (hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis. unassigned -
1.14.99.1 Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25983022&form=6&db=m Double-blind, placebo-controlled, randomized phase II study of TJ-14 (Hangeshashinto) for infusional fluorinated-pyrimidine-based colorectal cancer chemotherapy-induced oral mucositis. unassigned -
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3161220&form=6&db=m Enhanced in vivo platelet activation in subtypes of ischemic stroke. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930343&form=6&db=m Induction of cyclooxygenase-2 mRNA in gerbil hippocampal neurons after transient forebrain ischemia. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9259748&form=6&db=m Platelet activation and lipid peroxidation in patients with acute ischemic stroke. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10581376&form=6&db=m Ex vivo response to aspirin differs in stroke patients with single or recurrent events: a pilot study. causal interaction,unassigned 2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11158633&form=6&db=m Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11203433&form=6&db=m Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders. therapeutic application,unassigned 4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11704783&form=6&db=m How to get from antiplatelet to antithrombotic treatment. therapeutic application,unassigned 1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11739606&form=6&db=m Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11991232&form=6&db=m Enhanced protection by melatonin and meloxicam combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11997284&form=6&db=m Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12213634&form=6&db=m Cyclooxygenase-1 gene knockout does not alter middle cerebral artery occlusion in a mouse stroke model. therapeutic application,unassigned 1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12891663&form=6&db=m Cyclooxygenase-2 and stroke: the long and short of it. unassigned -
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12923200&form=6&db=m Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14508588&form=6&db=m Nonsteroidal anti-inflammatory drugs in patients with cardio- or cerebrovascular disorders. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14715958&form=6&db=m Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15041270&form=6&db=m Mutations within the cyclooxygenase-1 gene in aspirin non-responders with recurrence of stroke. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15122707&form=6&db=m Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. causal interaction,unassigned 2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138244&form=6&db=m A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15494992&form=6&db=m Anticoagulants versus antiplatelet therapy for preventing stroke in patients with nonrheumatic atrial fibrillation and a history of stroke or transient ischemic attack. ongoing research,therapeutic application,unassigned 1,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15656909&form=6&db=m Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15737438&form=6&db=m Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15780832&form=6&db=m Cardiovascular hazard and non-steroidal anti-inflammatory drugs. therapeutic application,unassigned 4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15813652&form=6&db=m Cyclo-oxygenase-2 inhibitors: when should they be used in the elderly? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15905461&form=6&db=m COX-2-derived prostacyclin modulates vascular remodeling. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15907047&form=6&db=m Animal models of cerebral ischemia for evaluation of drugs. therapeutic application,unassigned 4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15950485&form=6&db=m Estrogen stimulation of COX-2-derived PGI2 confers atheroprotection. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15990700&form=6&db=m COX-2 inhibitors and metabolism of essential fatty acids. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16038624&form=6&db=m Is COX-2 a perpetrator or a protector? Selective COX-2 inhibitors remain controversial. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127636&form=6&db=m COX-2 inhibitors--IBC conference. 12-13 April 1999, Coronado, CA, USA. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16190133&form=6&db=m Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids? causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16304418&form=6&db=m The Cardiovascular Pharmacology of COX-2 Inhibition. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16370958&form=6&db=m Comparative cardiovascular safety of traditional nonsteroidal anti-inflammatory drugs. therapeutic application,unassigned 2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16415488&form=6&db=m The future of traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors in the treatment of inflammation and pain. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16502013&form=6&db=m 1alpha,25-Dihydroxyvitamin D(3) treatment does not alter neuronal cyclooxygenase-2 expression in the cerebral cortex after stroke. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522321&form=6&db=m Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice. causal interaction,unassigned 4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16586083&form=6&db=m Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences? causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16614756&form=6&db=m Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16778472&form=6&db=m [Nonsteroidal anti-inflammatory agents--choice between disturbances of gastrointestinal tract and cardiovascular toxicity] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16808554&form=6&db=m Temporal relationship between use of NSAIDs, including selective COX-2 inhibitors, and cardiovascular risk. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16870271&form=6&db=m GPCR antagonists as an alternative to COX-2 inhibitors: a case for the PGE(2) EP(1) receptor. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16922642&form=6&db=m Clinical pharmacology of etoricoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17175107&form=6&db=m Chronic inhibition of cyclooxygenase-2 induces dendritic hypertrophy and limited functional improvement following motor cortex stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17176264&form=6&db=m Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17196469&form=6&db=m Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17350020&form=6&db=m Increased risk of incident stroke associated with the cyclooxygenase 2 (COX-2) G-765C polymorphism in African-Americans: the Atherosclerosis Risk in Communities Study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17402995&form=6&db=m Cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction and cerebrovascular accident. diagnostic usage,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17437665&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17495879&form=6&db=m Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17612044&form=6&db=m Anti-inflammatory drugs in the 21st century. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17901552&form=6&db=m Function of COX-2 and prostaglandins in neurological disease. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17926529&form=6&db=m [Guideline for prophylaxis and treatment of NSAID-associated gastric ulcerations] therapeutic application,unassigned 4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045153&form=6&db=m Increased neuronal injury in transgenic mice with neuronal overexpression of human cyclooxygenase-2 is reversed by hypothermia and rofecoxib treatment. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18173977&form=6&db=m Cardiovascular risk, hypertension, and NSAIDs. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18220787&form=6&db=m Computer aided drug design approaches to develop cyclooxygenase based novel anti-inflammatory and anti-cancer drugs. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18287589&form=6&db=m Cyclooxygenase-2 inhibitors and most traditional nonsteroidal anti-inflammatory drugs cause similar moderately increased risks of cardiovascular disease. therapeutic application,unassigned 4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18309167&form=6&db=m Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18347209&form=6&db=m Microsomal prostaglandin E2 synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18436878&form=6&db=m Nonaspirin NSAIDs, cyclooxygenase 2 inhibitors, and the risk for stroke. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18541831&form=6&db=m Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs and risk of stroke. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19193944&form=6&db=m Colonic bacterial translocation as a possible factor in stress-worsening experimental stroke outcome. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19384589&form=6&db=m PGF(2alpha) FP Receptor Contributes to Brain Damage Following Transient Focal Brain Ischemia. causal interaction,unassigned 3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19390185&form=6&db=m Influence of Cyclooxygenase-1 Genotype on ex vivo Aspirin Response in Patients at Risk for Stroke. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,1,2
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19446533&form=6&db=m Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19630805&form=6&db=m The translational therapeutics of prostaglandin inhibition in atherothrombosis. therapeutic application,unassigned 4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19641662&form=6&db=m Aspirin resistance: A fact or a myth? causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19674639&form=6&db=m Vioxx(R): What should we tell our patients? causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20059330&form=6&db=m Emotion recollected in tranquility: lessons learned from the COX-2 saga. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20128796&form=6&db=m Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity. unassigned -
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20170663&form=6&db=m Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20472470&form=6&db=m Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 Polymorphisms on 90-Day Ischemic Stroke Functional Outcome: A Novel Finding. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20498929&form=6&db=m [Nonsteroidal anti-inflammatory drugs: cardiovascular, cerebrovascular and renal effects] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20621166&form=6&db=m Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21236709&form=6&db=m Upregulated expression of Toll-like receptor 4 in peripheral blood of ischaemic stroke patients correlates with cyclooxygenase 2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,3,1
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21345578&form=6&db=m Targeting apoptosis pathways by Celecoxib in cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424029&form=6&db=m Clinico-pathological correlations in fatal ischemic stroke. An immunohistochemical study of human brain penumbra. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21635885&form=6&db=m Protective effect of Etoricoxib against middle cerebral artery occlusion induced transient focal cerebral ischemia in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,2
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21843661&form=6&db=m Microglia and cyclooxygenase-2: Possible therapeutic targets of progesterone for stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21957234&form=6&db=m Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal cyclooxygenase-2 function, lipid peroxidation, and neuroprotection. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21965326&form=6&db=m Signaling via the prostaglandin E? receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia. causal interaction,unassigned 4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22015313&form=6&db=m PGE(2) EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease. causal interaction,unassigned 3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22694049&form=6&db=m Experience-dependent brain plasticity after stroke: effect of ibuprofen and poststroke delay. causal interaction,unassigned 1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22763923&form=6&db=m Association of COX-2 rs20417 with aspirin resistance. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22972377&form=6&db=m Platelet Response to Aspirin in Chinese Stroke Patients is Independent of Genetic Polymorphisms of COX-1 C50T and COX-2 G765C. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23041537&form=6&db=m Neuroprotection mediated by the EP? receptor avoids the detrimental side effects of COX-2 inhibitors following ischaemic injury. therapeutic application,unassigned 3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23661962&form=6&db=m Efficacy and safety of short-term use of COX-2 inhibitors in patients after an acute stroke with musculoskeletal pain. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23832980&form=6&db=m [Antiplatelet therapy: update in secondary stroke prevention]. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23907768&form=6&db=m Cyclooxygenase-2 genetic polymorphism and stroke subtypes in chinese. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23995802&form=6&db=m The role of prostaglandin e2 in stroke-reperfusion injury. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24365321&form=6&db=m Nonsteroidal anti-inflammatory drugs exposure and the central nervous system. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24771108&form=6&db=m Tim-3 cell signaling and iNOS are involved in the protective effects of ischemic postconditioning against focal ischemia in rats. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24819536&form=6&db=m Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24930730&form=6&db=m Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,2,4,1
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24970746&form=6&db=m PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25562658&form=6&db=m Indomethacin preconditioning induces ischemic tolerance by modifying zinc availability in the brain. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748877&form=6&db=m Cardiovascular risks associated with non-aspirin non-steroidal anti-inflammatory drug use. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25957909&form=6&db=m COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,2,1
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26328537&form=6&db=m Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System. causal interaction,ongoing research,therapeutic application,unassigned 2,2,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26463949&form=6&db=m Cyclooxygenase-2 Inhibition Provides Lasting Protection Following Germinal Matrix Hemorrhage in Premature Infant Rats. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26543101&form=6&db=m Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26639722&form=6&db=m Rat paw oedema modeling and NSAIDs: Timing of effects. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26747234&form=6&db=m Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27318652&form=6&db=m Interaction between COX-1 and COX-2 Variants Associated with Aspirin Resistance in Chinese Stroke Patients. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28068952&form=6&db=m Interaction among COX-2, P2Y1 and GPIIIa gene variants is associated with aspirin resistance and early neurological deterioration in Chinese stroke patients. therapeutic application,unassigned 1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28300652&form=6&db=m Increased risk of stroke in patients with osteoarthritis: a population-based cohort study. ongoing research,therapeutic application,unassigned 1,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28315303&form=6&db=m Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28431615&form=6&db=m Association between PTGS1 polymorphisms and functional outcomes in Chinese patients with stroke during aspirin therapy: Interaction with smoking. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28478978&form=6&db=m Interactions among Variants in Eicosanoid Genes Increase Risk of Atherothrombotic Stroke in Chinese Populations. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28912645&form=6&db=m Anti-inflammatory Effect of Glucagon Like Peptide-1 Receptor Agonist, Exendin-4, through Modulation of IB1/JIP1 Expression and JNK Signaling in Stroke. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29399074&form=6&db=m Protective effects of D-Limonene against transient cerebral ischemia in stroke-prone spontaneously hypertensive rats. unassigned -
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30090656&form=6&db=m Glibenclamide Enhances the Therapeutic Benefits of Early Hypothermia after Severe Stroke in Rats. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30396759&form=6&db=m In vivo evaluation of [11C]TMI, a COX-2 selective PET tracer, in baboons. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31208307&form=6&db=m Accelerated Atherosclerosis in Rheumatoid Arthritis: Mechanisms and Treatment. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32251635&form=6&db=m Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32328128&form=6&db=m Discovery of Herbal Pairs Containing Gastrodia elata Based on Data Mining and the Delphi Expert Questionnaire and Their Potential Effects on Stroke through Network Pharmacology. unassigned -
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32545964&form=6&db=m Gadolinium-Based Neuroprognostic Magnetic Resonance Imaging Agents Suppress COX-2 for Prevention of Reperfusion Injury after Stroke. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32777346&form=6&db=m Inhibition of cyclooxygenase-1 does not reduce mortality in post-ischemic stroke rats. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32973660&form=6&db=m Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33227236&form=6&db=m Spreading Depressions and Periinfarct Spreading Depolarizations in the Context of Cortical Plasticity. causal interaction,unassigned 1,0
1.14.99.1 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34071951&form=6&db=m Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Stroke, Lacunar http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23852948&form=6&db=m Cyclooxygenase 2 genetic polymorphism may increase the risk of developing leukoaraiosis in chinese. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Stupor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1900890&form=6&db=m The role of prostaglandin synthetase in the rate depressant effects and narcosis caused by ethanol. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6337914&form=6&db=m Prostaglandin metabolism and prostacyclin in cerebral vasospasm. therapeutic application,unassigned 1,0
1.14.99.1 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7674011&form=6&db=m Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report. causal interaction,therapeutic application,unassigned 2,3,0
1.14.99.1 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9593840&form=6&db=m Effects of oxyhemoglobin in vitro in cerebral arteries from normal animals and animals subject to subarachnoid hemorrhage or indomethacin treatment. therapeutic application,unassigned 1,0
1.14.99.1 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9626297&form=6&db=m Inducible cyclooxygenase expression in canine basilar artery after experimental subarachnoid hemorrhage. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11270554&form=6&db=m Overexpression of cyclooxygenase-2 in rabbit basilar artery endothelial cells after subarachnoid hemorrhage. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21725746&form=6&db=m The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Subarachnoid Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27044361&form=6&db=m Role of Cyclooxygenase-2 in Relation to Nitric Oxide and Endothelin-1 on Pathogenesis of Cerebral Vasospasm After Subarachnoid Hemorrhage in Rabbit. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Sudden Unexpected Death in Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23030268&form=6&db=m A possible role of cyclooxygenase-2 in the relationship between sleep and sudden unexpected death in epilepsy. ongoing research,unassigned 3,0
1.14.99.1 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9106644&form=6&db=m Protective effects of silymarin against photocarcinogenesis in a mouse skin model. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11060900&form=6&db=m Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15175041&form=6&db=m Treatment with 5-fluorouracil and celecoxib displays synergistic regression of ultraviolet light B-induced skin tumors. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17238138&form=6&db=m Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21435898&form=6&db=m Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Sunburn http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23403620&form=6&db=m Effect of Artocarpus communis Extract on UVB Irradiation-Induced Oxidative Stress and Inflammation in Hairless Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Sweet Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21612568&form=6&db=m Sweet's syndrome associated with the intake of a selective cyclooxygenase-2 (COX-2) inhibitor. therapeutic application,unassigned 4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9185970&form=6&db=m Kinetic gait analysis assessment of meloxicam efficacy in a sodium urate-induced synovitis model in dogs. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11048802&form=6&db=m Intraarticular osteoid osteoma associated with synovitis: a possible role of cyclooxygenase-2 expression by osteoblasts in the nidus. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12584683&form=6&db=m Effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs. therapeutic application,unassigned 4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13680221&form=6&db=m Expression of cyclooxygenase-2 in chondroblastoma: immunohistochemical analysis with special emphasis on local inflammatory reaction. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15077695&form=6&db=m In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15262246&form=6&db=m Participation of cyclooxygenase-1 in prostaglandin E2 release from synovitis tissue in primary osteoarthritis in vitro. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15337183&form=6&db=m Immunohistochemical localization of cyclooxygenase-1 and -2 in synovial tissues from patients with internal derangement or osteoarthritis of the temporomandibular joint. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15563928&form=6&db=m Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15698798&form=6&db=m In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17408711&form=6&db=m Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18573668&form=6&db=m Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1beta. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19141058&form=6&db=m Expression of cyclooxygenase-1 and -2 in IL-1beta-induced synovitis of the temporomandibular joint. unassigned -
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20444036&form=6&db=m Analgesic and anti-inflammatory actions of robenacoxib in acute joint inflammation in dog. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21727109&form=6&db=m Novel protagonists in autoinflammatory arthritis of familial mediterranean Fever. ongoing research,unassigned 2,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22240988&form=6&db=m Pro-Apoptotic Effects of Tepoxalin, a Cyclooxygenase/Lipoxygenase Dual Inhibitor, on Canine Synovial Fibroblasts. therapeutic application,unassigned 1,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24671668&form=6&db=m Sulforaphane Inhibits IL-1?-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts and the Production of MMPs, COX-2, and PGE2. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26028139&form=6&db=m Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27493016&form=6&db=m Evaluation of the dose-response relationship of oral robenacoxib in urate crystal-induced acute stifle synovitis in dogs. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28216685&form=6&db=m Comparative efficacy of oral meloxicam and phenylbutazone in 2 experimental pain models in the horse. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30585984&form=6&db=m Contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Synovitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33507995&form=6&db=m Variations in gene expression levels with severity of synovitis in dogs with naturally occurring stifle osteoarthritis. unassigned -
1.14.99.1 Syphilis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11116807&form=6&db=m Rectal stricture associated with the long-term use of|| ibuprofen suppositories. therapeutic application,unassigned 1,0
1.14.99.1 Syphilis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11142931&form=6&db=m Rectal stricture associated with the long-term use of ibuprofen suppositories. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2579381&form=6&db=m Cardiac dysfunction caused by purified human C3a anaphylatoxin. therapeutic application,unassigned 1,0
1.14.99.1 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3006196&form=6&db=m Role of prostaglandins in marihuana-induced bronchodilation. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6807698&form=6&db=m Reversal of bradykinin-induced reflex tachycardia to bradycardia by captopril; evidence for prostacyclin involvement. therapeutic application,unassigned 2,0
1.14.99.1 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8430938&form=6&db=m Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086. therapeutic application,unassigned 2,0
1.14.99.1 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8901480&form=6&db=m Prostaglandins and the antiarrhythmic effect of preconditioning in the isolated rat heart. causal interaction,unassigned 4,0
1.14.99.1 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10701324&form=6&db=m [Effect of cyclooxygenase inhibition on the adaptation of coronary blood flow to tachycardia] ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Tachycardia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23684565&form=6&db=m Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock. causal interaction,ongoing research,unassigned 1,2,0
1.14.99.1 Tachypnea http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16627682&form=6&db=m Mediator mechanisms involved in TRPV1 and P2X receptor-mediated, ROS-evoked bradypneic reflex in anesthetized rats. therapeutic application,unassigned 1,0
1.14.99.1 Takotsubo Cardiomyopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18092115&form=6&db=m A case of takotsubo cardiomyopathy precipitated by lumiracoxib, a selective COX-2 inhibitor. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Tauopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30530228&form=6&db=m Neuroprotection and improvement of the histopathological and behavioral impairments in a murine Alzheimer's model treated with Zephyranthes carinata alkaloids. causal interaction,unassigned 1,0
1.14.99.1 Temporomandibular Joint Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16253161&form=6&db=m [The role of hypoxia on expression of cyclooxygenase-2 in synovial fibroblasts derived from human temporomandular joint] diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Tendinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12072760&form=6&db=m Increased expression of transforming growth factor-beta1 in patellar tendinosis. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Tendinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14504032&form=6&db=m Cyclic mechanical stretching of human tendon fibroblasts increases the production of prostaglandin E2 and levels of cyclooxygenase expression: a novel in vitro model study. unassigned -
1.14.99.1 Tendinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17364667&form=6&db=m Effects of celecoxib on migration, proliferation and collagen expression of tendon cells. therapeutic application,unassigned 4,0
1.14.99.1 Tendinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20737183&form=6&db=m Low-level laser therapy (LLLT; 780 nm) acts differently on mRNA expression of anti- and pro-inflammatory mediators in an experimental model of collagenase-induced tendinitis in rat. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0
1.14.99.1 Tendinopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21910734&form=6&db=m Infrared (810 nm) low-level laser therapy in rat achilles tendinitis: a consistent alternative to drugs. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Tension-Type Headache http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15456339&form=6&db=m Lumiracoxib. causal interaction,diagnostic usage,therapeutic application,unassigned 2,1,3,0
1.14.99.1 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10640421&form=6&db=m Lack of cyclooxygenase-2 inhibits growth of teratocarcinomas in mice. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Teratocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710986&form=6&db=m Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. diagnostic usage,therapeutic application,unassigned 1,1,0
1.14.99.1 Teratoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605016&form=6&db=m Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1
1.14.99.1 Teratoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21131835&form=6&db=m COX-2 expression in nonepithelial ovarian malignancies. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,1,1
1.14.99.1 Testicular Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12957459&form=6&db=m Cyclooxygenase-1 and -2 in human testicular tumours. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Testicular Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19447423&form=6&db=m CpG island hypermethylation of cell-free circulating serum DNA in patients with testicular cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Testicular Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21475860&form=6&db=m Arachidonic acid pathway: A molecular target in human testicular cancer (Review). causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Tetanus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26498481&form=6&db=m Increased cyclooxygenase-2 and nuclear factor-?B/p65 expression in mouse hippocampi after systemic administration of tetanus toxin. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Thiamine Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18481165&form=6&db=m Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Thrombasthenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3563982&form=6&db=m DDAVP-induced correction of prolonged bleeding time in patients with congenital platelet function defects. unassigned -
1.14.99.1 Thrombasthenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6429881&form=6&db=m A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 Thrombasthenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14602548&form=6&db=m Platelet function tests using platelet aggregometry: need for repetition of the test for diagnosis of defective platelet function. diagnostic usage,unassigned 3,0
1.14.99.1 Thrombocythemia, Essential http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9544970&form=6&db=m Aspirin increases the bleeding side effects in essential thrombocythemia independent of the cyclooxygenase pathway: role of the lipoxygenase pathway. causal interaction,unassigned 1,0
1.14.99.1 Thrombocythemia, Essential http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19887674&form=6&db=m The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Thrombocythemia, Essential http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28378909&form=6&db=m In silico modeling of the antiplatelet pharmacodynamics of low-dose aspirin in health and disease. diagnostic usage,ongoing research,unassigned 4,2,0
1.14.99.1 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6452106&form=6&db=m Inhibition of thrombocytopenic episodes caused by the Arthus reaction, the sub-lethal Forssman reaction and ADP. therapeutic application,unassigned 1,0
1.14.99.1 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7846692&form=6&db=m Haemodynamic and haematologic effects of Acanthaster planci venom in dogs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27007231&form=6&db=m Clinical Profile of Cyclooxygenase-2 Inhibitors in Treating Non-Small Cell Lung Cancer: A Meta-Analysis of Nine Randomized Clinical Trials. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29440919&form=6&db=m Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33553396&form=6&db=m Clinical benefit of COX-2 inhibitors in the adjuvant chemotherapy of advanced non-small cell lung cancer: A systematic review and meta-analysis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Thrombocytopenia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33718298&form=6&db=m Current Controversy on Platelets and Patent Ductus Arteriosus Closure in Preterm Infants. therapeutic application,unassigned 4,0
1.14.99.1 Thromboembolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3923041&form=6&db=m Effects of platelet-modifying drugs on arterial thromboembolism in baboons. Aspirin potentiates the antithrombotic actions of dipyridamole and sulfinpyrazone by mechanism(s) independent of platelet cyclooxygenase inhibition. causal interaction,ongoing research,therapeutic application,unassigned 2,1,2,0
1.14.99.1 Thromboembolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8465269&form=6&db=m Free radical scavenging mechanisms during pulmonary thromboembolism in rats. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Thromboembolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11333348&form=6&db=m Approaches to rheumatoid arthritis in 2000. causal interaction,unassigned 3,0
1.14.99.1 Thromboembolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623548&form=6&db=m Breast cancer prevention--clinical trials strategies involving aromatase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thromboembolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30496799&form=6&db=m PIK3CA hotspot mutations and cyclooxygenase-2 expression in ovarian clear cell carcinomas: a close association with stromal features. causal interaction,diagnostic usage,unassigned 3,1,0
1.14.99.1 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166966&form=6&db=m COX-2 inhibitors and hypercoagulability. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Thrombophilia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32688212&form=6&db=m Revealing the mechanisms and the material basis of Rubia cordifolia L. on abnormal uterine bleeding with uniting simultaneous determination of four components and systematic pharmacology approach-experimental validation. therapeutic application,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=384949&form=6&db=m The role of prostaglandins in platelet-vessel wall interaction. therapeutic application,unassigned 3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1554206&form=6&db=m Cyclooxygenase inhibition aggravates pulmonary hypertension and deteriorates gas exchange in canine pulmonary embolism. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1830517&form=6&db=m Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on occlusive thrombosis elicited by endothelial cell injury or by deep vascular damage in canine coronary arteries. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1830520&form=6&db=m Antithrombotic therapy for deep arterial injury by angioplasty. Efficacy of common platelet inhibition compared with thrombin inhibition in pigs. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2413666&form=6&db=m Effect of platelet inhibition on experimental venous thrombosis in the rabbit. therapeutic application,unassigned 3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2470355&form=6&db=m Role of eicosanoids in the kappa-carrageenin rat tail thrombosis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134741&form=6&db=m Exchange of cyclooxygenase dependent metabolites between vessel wall and platelets in arterial thrombosis. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3937181&form=6&db=m The effect of inhibition of endothelial cell cyclooxygenase on arterial thrombosis. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6517902&form=6&db=m Carrageenin-induced thrombosis in the rat and mouse as a test model of substances influencing thrombosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7517491&form=6&db=m Involvement of nitric oxide and cyclooxygenase products in photoactivation-induced microvascular occlusion. causal interaction,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7955200&form=6&db=m Inhibition of growth of thrombus on fresh mural thrombus. Targeting optimal therapy. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8477903&form=6&db=m Platelet adhesivity to subendothelium is influenced by polymorphonuclear leukocytes: studies with aspirin and salicylate. causal interaction,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8569218&form=6&db=m Failure of calcium channel blockade to reduce platelet-mediated cyclic flow variations in dogs with coronary stenosis and endothelial injury. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8616915&form=6&db=m Prevention of arterial thrombosis by adenovirus-mediated transfer of cyclooxygenase gene. diagnostic usage,ongoing research,unassigned 1,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8657765&form=6&db=m The effect of ketorolac on microvascular thrombosis in an experimental rabbit model. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9177102&form=6&db=m Prostacyclin and nitric oxide-related gene transfer in preventing arterial thrombosis and restenosis. unassigned -
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9218700&form=6&db=m Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022. ongoing research,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10093889&form=6&db=m A rationale for targeting antithrombotic therapy at the vessel wall: improved antithrombotic effect and decreased risk of bleeding. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10429451&form=6&db=m [A new medical treatment for thrombosis by genetic engineering] causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10943882&form=6&db=m Thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors. A report of four cases. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11049697&form=6&db=m Thromboxane-B(2) levels in serum of rabbits receiving a single intravenous dose of aqueous extract of garlic and onion. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11315941&form=6&db=m Cyclooxygenase 2 inhibition and thrombosis: comment on the article by Crofford et al. therapeutic application,unassigned 2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11350912&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11368948&form=6&db=m Inducible cyclooxygenase-2 expression after experimental intracerebral hemorrhage. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11502709&form=6&db=m Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11587283&form=6&db=m COX-2 inhibition and thrombotic tendency: a need for surveillance. causal interaction,unassigned 4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11909559&form=6&db=m Relative risk of cardiovascular events in patients with rheumatoid arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12088280&form=6&db=m Cyclooxygenase, lipoxygenase and tumor angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,1,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12105157&form=6&db=m Efficacy assessment of meloxicam, a preferential cyclooxygenase-2 inhibitor, in acute coronary syndromes without ST-segment elevation: the Nonsteroidal Anti-Inflammatory Drugs in Unstable Angina Treatment-2 (NUT-2) pilot study. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12192304&form=6&db=m Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12352013&form=6&db=m Cyclooxygenase-2 and atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12398900&form=6&db=m On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767724&form=6&db=m Prevention of thrombosis and vascular inflammation: benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12783090&form=6&db=m The potential of selective COX-2 inhibitors in inflammatory and other diseases. causal interaction,unassigned 3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12874094&form=6&db=m Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12911235&form=6&db=m Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12949886&form=6&db=m Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma. causal interaction,unassigned 4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14649387&form=6&db=m Potential cardiovascular effects of COX-2 selective nonsteroidal antiinflammatory drugs. unassigned -
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14736287&form=6&db=m Reflectance spectroscopy of clotting blood: a description of the time-dependent behavior. therapeutic application,unassigned 4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15063354&form=6&db=m Cyclooxygenase-2 and inflammation in atherosclerosis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15094969&form=6&db=m Relationship between cyclooxygenase-2 inhibition and thrombogenesis. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15151474&form=6&db=m Cardiovascular effects of selective cyclooxygenase-2 inhibitors. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15283037&form=6&db=m [Specific cyclo-oxygenase-2 inhibitors in cardiovascular pathology] causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15482377&form=6&db=m Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model. ongoing research,unassigned 2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15492320&form=6&db=m Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15703677&form=6&db=m Gastroduodenal mucosal defense: role of endogenous mediators. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15824211&form=6&db=m Local gene transduction of cyclooxygenase-1 increases blood flow in injured atherosclerotic rabbit arteries. unassigned -
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16113940&form=6&db=m Adverse effects of COX-2 inhibitors. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16274925&form=6&db=m Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens. causal interaction,unassigned 4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16325014&form=6&db=m Regulation of cerebral microvascular endothelial cell cyclooxygenase-2 message and activity by blood derived vasoactive agents. ongoing research,unassigned 4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16401468&form=6&db=m Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16609625&form=6&db=m [Prevention of thrombosis and vascular inflammation: importance of combined cyclooxygenase and 5-lipoxygenase inhibitors] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16688111&form=6&db=m COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy. ongoing research,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17098744&form=6&db=m Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. causal interaction,unassigned 3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17276520&form=6&db=m Balancing prostanoid activity in the human vascular system. causal interaction,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17441341&form=6&db=m [Role of cyclooxygenase-2 in pulmonary microcirculation disorder in rats with acute pancreatitis] causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17641676&form=6&db=m 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway. unassigned -
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17849057&form=6&db=m A thromboxane A2/prostaglandin H2 receptor antagonist (S18886) shows high antithrombotic efficacy in an experimental model of stent-induced thrombosis. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17921331&form=6&db=m Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18332613&form=6&db=m Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition? ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18375790&form=6&db=m Cyclooxygenase-2-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosis. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18465536&form=6&db=m NCX-4016 (NicOx SA). causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18503633&form=6&db=m Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18571222&form=6&db=m Prothrombotic effect of Rofecoxib in a murine venous thrombosis model. ongoing research,unassigned 3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19075637&form=6&db=m Cyclooxygenase inhibitors: instrumental drugs to understand cardiovascular homeostasis and arterial thrombosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19236624&form=6&db=m Elevated plasma prostaglandins and acetylated histone in monocytes in Type 1 diabetes patients. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19345949&form=6&db=m Antithrombotic and antiplatelet activities of fenofibrate, a lipid-lowering drug. causal interaction,unassigned 4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19471752&form=6&db=m [Specific cyclooxygenase-2 inhibitor analgesics: therapeutic advances.] causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19679838&form=6&db=m Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation. causal interaction,unassigned 3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19712933&form=6&db=m Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk. causal interaction,ongoing research,unassigned 1,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19917882&form=6&db=m Endothelial progenitor cells bind and inhibit platelet function and thrombus formation. causal interaction,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19955429&form=6&db=m Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1. unassigned -
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20092437&form=6&db=m A Review on the risk of myocardial infarction associated with the NSAID diclofenac. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20350286&form=6&db=m Paradoxical Thrombotic Effects of Aspirin: Experimental Study on 1000 Animals. therapeutic application,unassigned 2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21629780&form=6&db=m Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21838667&form=6&db=m 12-Lipoxygenase: A Potential Target for Novel Anti-Platelet Therapeutics. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21844189&form=6&db=m Intracellular Erythrocyte PAF Acetylhydrolase 1 Inactivates Aspirin in Blood. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22553252&form=6&db=m Vascular COX-2 modulates blood pressure and thrombosis in mice. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22852789&form=6&db=m Development of a perfusion chamber assay to study in real time the kinetics of thrombosis and the antithrombotic characteristics of antiplatelet drugs. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23412354&form=6&db=m Antiplatelet activity of L-sulforaphane by regulation of platelet activation factors, glycoprotein IIb/IIIa and thromboxane A2. therapeutic application,unassigned 3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23629578&form=6&db=m Cardiovascular effects of common analgesics. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24892779&form=6&db=m Preparation and characterization of a novel aspirin derivative with anti-thrombotic and gastric mucosal protection properties. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25339356&form=6&db=m Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27440004&form=6&db=m Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28536720&form=6&db=m Prostaglandin-endoperoxide synthase-2 deletion affects the natural trafficking of Annexin A2 in monocytes and favours venous thrombosis in mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28700965&form=6&db=m Inhibitory effects of ASP6537, a selective cyclooxygenase-1 inhibitor, on thrombosis and neointima formation in rats. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29552053&form=6&db=m Impact of Aspirin Eugenol Ester on Cyclooxygenase-1, Cyclooxygenase-2, C-Reactive Protein, Prothrombin and Arachidonate 5-Lipoxygenase in Healthy Rats. ongoing research,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29748334&form=6&db=m Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29877658&form=6&db=m NSAIDs and heart failure: A dangerous relationship. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,1,4
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30108767&form=6&db=m Structure-activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009-2016). causal interaction,therapeutic application,unassigned 1,3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30367682&form=6&db=m Arterial Thrombosis Is Accompanied by Elevated Mitogen-Activated Protein Kinase (MAPK) and Cyclooxygenase-2 (COX-2) Expression via Toll-Like Receptor 4 (TLR-4) Activation by S100A8/A9. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30737317&form=6&db=m A seven-step plan for becoming a moderately rich and famous biochemist. therapeutic application,unassigned 3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30819914&form=6&db=m Differences and similarities in ibrutinib and acalabrutinib effects on platelet functions. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32467143&form=6&db=m Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32592197&form=6&db=m Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin. therapeutic application,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33038834&form=6&db=m Polyunsaturated fatty acid biosynthesis pathway and genetics. implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19?,??,?,??. causal interaction,unassigned 1,0
1.14.99.1 Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34428833&form=6&db=m Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth. causal interaction,unassigned 1,0
1.14.99.1 Thrombotic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17164137&form=6&db=m Human prostacyclin receptor structure and function from naturally-occurring and synthetic mutations. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3923563&form=6&db=m Incorporation of 5,8,11,14-eicosatetraynoic acid (ETYA) into cell lipids: competition with arachidonic acid for esterification. ongoing research,unassigned 3,0
1.14.99.1 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16823844&form=6&db=m COX-2 upregulation in thymomas and thymic carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1
1.14.99.1 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20332435&form=6&db=m Curcumin targets FOLFOX-surviving colon cancer cells via inhibition of EGFRs and IGF-1R. causal interaction,unassigned 4,0
1.14.99.1 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29942116&form=6&db=m Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Thymoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29966585&form=6&db=m a-Tocopherol modifies the expression of genes related to oxidative stress and apoptosis during invitro maturation and enhances the developmental competence of rabbit oocytes. ongoing research,unassigned 2,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15139997&form=6&db=m Expression of COX-2 is increased with age in papillary thyroid cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15299197&form=6&db=m Expression of cyclooxygenase-2 and thromboxane synthase in non-neoplastic and neoplastic thyroid lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15475935&form=6&db=m Role of COX-2, thromboxane A2 synthase, and prostaglandin I2 synthase in papillary thyroid carcinoma growth. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817909&form=6&db=m High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16728574&form=6&db=m VEGF-C and COX-2 expression in papillary thyroid cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16772349&form=6&db=m Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759871&form=6&db=m Immunohistochemical Demonstration of Membrane-bound Prostaglandin E(2) Synthase-1 in Papillary Thyroid Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20120873&form=6&db=m [Expression of COX-2 and VEGF-C in papillary thyroid carcinoma and their relationship to cervical lymph metastases] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20640858&form=6&db=m Diagnostic utility of immunohistochemical panel in various thyroid pathologies. diagnostic usage,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21214962&form=6&db=m COX-2 expression in papillary thyroid carcinoma (PTC) in cytological material obtained by fine needle aspiration biopsy (FNAB). unassigned -
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21335003&form=6&db=m Correlation of E-cadherin, VEGF, COX-2 expression to prognostic parameters in papillary thyroid carcinoma. diagnostic usage,ongoing research,unassigned 2,1,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587354&form=6&db=m Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33327467&form=6&db=m Prognostic Significance of COX-2 Overexpression in BRAF-Mutated Middle Eastern Papillary Thyroid Carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2
1.14.99.1 Thyroid Carcinoma, Anaplastic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30140269&form=6&db=m Prostaglandin E2 Secreted by Thyroid Cancer Cells Contributes to Immune Escape Through the Suppression of Natural Killer (NK) Cell Cytotoxicity and NK Cell Differentiation. unassigned -
1.14.99.1 Thyroid Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18362501&form=6&db=m Cyclooxygenase-2 expression in human thyroid disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788675&form=6&db=m Cyclooxygenase-2 expression in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11889377&form=6&db=m Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713627&form=6&db=m Cyclooxygenase-2 expression in thyroid neoplasms. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947945&form=6&db=m Cyclooxygenase-2 in normal, hyperplastic and neoplastic follicular cells of the human thyroid gland. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16091477&form=6&db=m Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16362262&form=6&db=m Cyclooxygenase 1 and 2 expressions in the human thyroid gland. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522694&form=6&db=m Phase II study of celecoxib in metastatic differentiated thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16831027&form=6&db=m Immunoexpression of multidrug-resistance protein 2 and cyclooxygenase 2 in medullary thyroid carcinomas. therapeutic application,unassigned 1,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16997128&form=6&db=m 15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17179688&form=6&db=m Cyclooxygenase-2 and inducible nitric oxide synthase expression in thyroid neoplasms and their clinicopathological correlation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,2
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17274057&form=6&db=m Cyclooxygenase-2 expression in medullary thyroid carcinoma. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18045954&form=6&db=m Cyclooxygenase-2 inhibitors prevent the development of chemoresistance phenotype in a breast cancer cell line by inhibiting glycoprotein p-170 expression. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19048457&form=6&db=m COX-2 expression in highly aggressive thyroid malignancies - indication for a possible therapeutic option? causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22305971&form=6&db=m Celecoxib, a cyclooxygenase-2 inhibitor, potentiates the chemotherapic effect of vinorelbine in the medullary thyroid cancer TT cell line. ongoing research,unassigned 2,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22419920&form=6&db=m Cyclooxygenase-2 expression and its association with thyroid lesions. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22577338&form=6&db=m COX-2 expression and tumor angiogenesis in thyroid carcinoma patients among northeast Chinese population-result of a single-center study. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23109979&form=6&db=m Detection of Survivin and COX-2 in Thyroid Carcinoma: Anaplastic Carcinoma Shows Overexpression of Nuclear Survivin and Low COX-2 Expression. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24346019&form=6&db=m Antitumor activity of celecoxib, a selective cyclooxygenase-2 inhibitor, in medullary thyroid carcinoma. therapeutic application,unassigned 4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587354&form=6&db=m Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26426828&form=6&db=m Thyroid Cancer and Nonsteroidal Anti-Inflammatory Drug Use: A Pooled Analysis of Patients Older Than 40 Years of Age. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28521457&form=6&db=m Expression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29306248&form=6&db=m Cyclooxygenase-2 (COX-2) gene polymorphism in patients with differentiated thyroid carcinomas in the Turkish population diagnostic usage,ongoing research,unassigned 2,4,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30140269&form=6&db=m Prostaglandin E2 Secreted by Thyroid Cancer Cells Contributes to Immune Escape Through the Suppression of Natural Killer (NK) Cell Cytotoxicity and NK Cell Differentiation. unassigned -
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31113465&form=6&db=m Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism. causal interaction,diagnostic usage,ongoing research,unassigned 1,2,3,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31113934&form=6&db=m TFAP2B overexpression contributes to tumor growth and progression of thyroid cancer through the COX-2 signaling pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Thyroid Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32505238&form=6&db=m Histopathological and Immunohistochemical Characteristics of Thyroid Carcinoma in the Dog. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,1,3,1
1.14.99.1 Thyroid Nodule http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11788675&form=6&db=m Cyclooxygenase-2 expression in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Thyroid Nodule http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717230&form=6&db=m Immunohistochemical expression of COX-2 in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Thyroid Nodule http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15879365&form=6&db=m Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Thyroid Nodule http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16522694&form=6&db=m Phase II study of celecoxib in metastatic differentiated thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,2
1.14.99.1 Thyroiditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11889377&form=6&db=m Cyclooxygenase-2 expression in human thyroid carcinoma and Hashimoto's thyroiditis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Thyroiditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14717230&form=6&db=m Immunohistochemical expression of COX-2 in thyroid nodules. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Thyroiditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18362501&form=6&db=m Cyclooxygenase-2 expression in human thyroid disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Thyroiditis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25130519&form=6&db=m CD8+ tumour-infiltrating lymphocytes and COX2 expression may predict relapse in differentiated thyroid cancer. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,3,0
1.14.99.1 Thyroiditis, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11939728&form=6&db=m Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors: significant correlation with inducible nitric oxide synthase. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Thyroiditis, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15817909&form=6&db=m High prevalence of cyclooxygenase 2 expression in papillary thyroid carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0
1.14.99.1 Thyroiditis, Autoimmune http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25587354&form=6&db=m Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Tinnitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12736364&form=6&db=m Salicylate induces tinnitus through activation of cochlear NMDA receptors. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Tinnitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18225604&form=6&db=m Cochlear NMDA receptor blockade prevents salicylate-induced tinnitus. unassigned -
1.14.99.1 Tinnitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18632935&form=6&db=m Salicylate enables cochlear arachidonic-acid-sensitive NMDA receptor responses. causal interaction,unassigned 1,0
1.14.99.1 Tinnitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21271589&form=6&db=m Expression of COX-2 and NMDA receptor genes at the cochlea and midbrain in salicylate-induced tinnitus. ongoing research,unassigned 1,0
1.14.99.1 Tinnitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23533584&form=6&db=m Effects of C-phycocyanin and Spirulina on Salicylate-Induced Tinnitus, Expression of NMDA Receptor and Inflammatory Genes. ongoing research,unassigned 3,0
1.14.99.1 Tinnitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25779473&form=6&db=m Assessment of the potential ototoxicity of high-dose celecoxib, a selective cyclooxygenase-2 inhibitor, in rats. causal interaction,diagnostic usage,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Tinnitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27997730&form=6&db=m Inhibitors of oxidative and hydrolytic endocannabinoid degradation do not enhance depolarization-induced suppression of excitation on dorsal cochlear nucleus glycinergic neurons. causal interaction,unassigned 3,0
1.14.99.1 Tinnitus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29462704&form=6&db=m Enhancement of Endocannabinoid-dependent Depolarization-induced Suppression of Excitation in Glycinergic Neurons by Prolonged Exposure to High Doses of Salicylate. therapeutic application,unassigned 4,0
1.14.99.1 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12203806&form=6&db=m Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15632379&form=6&db=m Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15797624&form=6&db=m Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,1
1.14.99.1 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20857495&form=6&db=m Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0
1.14.99.1 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21069476&form=6&db=m COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Tongue Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24560404&form=6&db=m Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-c and lymph node metastasis in human oral tongue cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Tonsillitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2847691&form=6&db=m [Enzyme histochemical characteristics of prostaglandin synthetase, adenylate cyclase and cAMP in a focus of inflammation in chronic tonsillitis] ongoing research,unassigned 3,0
1.14.99.1 Tonsillitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20699501&form=6&db=m Expression of cyclooxygenase-1 and 2 in chronic tonsillitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Tonsillitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33777165&form=6&db=m The Acidic Fraction of Isatidis Radix Regulates Inflammatory Response in LPS-Stimulated RAW264.7 Macrophages through MAPKs and NF-?B Pathway. therapeutic application,unassigned 1,0
1.14.99.1 Toothache http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14509173&form=6&db=m [Pain management after third molar extraction. Observations of the use of mefenamic acid and rofecoxib in the treatment of postoperative pain in the dental office] causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Toothache http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22814005&form=6&db=m Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Tourette Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15527551&form=6&db=m Anti-inflammatory therapy with a COX-2 inhibitor in Tourette's syndrome. therapeutic application,unassigned 4,0
1.14.99.1 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30809216&form=6&db=m Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0
1.14.99.1 Toxoplasmosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34135407&form=6&db=m Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants. ongoing research,unassigned 4,0
1.14.99.1 Tremor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20166930&form=6&db=m Progress in COX-2 inhibitors: a journey so far. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23355539&form=6&db=m Lapatinib-Mediated Cyclooxygenase-2 Expression via Epidermal Growth Factor Receptor/HuR Interaction Enhances the Aggressiveness of Triple-Negative Breast Cancer Cells. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24829621&form=6&db=m Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24965402&form=6&db=m Expression of cyclooxygenase-2 and Bcl-2 in breast cancer and their relationship with triple-negative disease. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054056&form=6&db=m Cyclooxygenase-2 expression in non-metastatic triple-negative breast cancer patients. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25068292&form=6&db=m Differential peripheral blood gene expression profile based on Her2 expression on primary tumors of breast cancer patients. unassigned -
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27257388&form=6&db=m Upregulation of Cyclooxygenase-2/Prostaglandin E2 (COX-2/PGE2) Pathway Member Multiple Drug Resistance-Associated Protein 4 (MRP4) and Downregulation of Prostaglandin Transporter (PGT) and 15-Prostaglandin Dehydrogenase (15-PGDH) in Triple-Negative Breast Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28054666&form=6&db=m Cyclooxygenase-2 regulates TGF?-induced cancer stemness in triple-negative breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28152501&form=6&db=m Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29596308&form=6&db=m EP4 as a Therapeutic Target for Aggressive Human Breast Cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30152521&form=6&db=m Understanding the tumour microenvironment communication network from a NOS2/COX2 perspective. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30987191&form=6&db=m Future Aspects for Cannabinoids in Breast Cancer Therapy. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31705927&form=6&db=m Centromere protein U (CENPU) enhances angiogenesis in triple-negative breast cancer by inhibiting ubiquitin-proteasomal degradation of COX-2. therapeutic application,unassigned 1,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33588911&form=6&db=m Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33607360&form=6&db=m Gancochlearols E - I, meroterpenoids from Ganoderma cochlear against COX-2 and triple negative breast cancer cells and the absolute configuration assignment of ganomycin K. ongoing research,unassigned 1,0
1.14.99.1 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34041621&form=6&db=m Combinatorial targeting of microRNA-26b and microRNA-101 exerts a synergistic inhibition on cyclooxygenase-2 in brain metastatic triple-negative breast cancer cells. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Trismus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17665051&form=6&db=m The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0
1.14.99.1 Trismus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21415660&form=6&db=m Corticosteroids or cyclooxygenase 2-selective inhibitor medication for the management of pain and swelling after third-molar surgery. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9793797&form=6&db=m The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis-induced monoarticular arthritis in the rat. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15721611&form=6&db=m Reaction of haem containing proteins and enzymes with hydroperoxides: the radical view. therapeutic application,unassigned 1,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17692387&form=6&db=m In search of cyclooxygenase inhibitors, anti-Mycobacterium tuberculosis and anti-malarial drugs from Thai flora and microbes. therapeutic application,unassigned 3,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19140872&form=6&db=m Inhibition of TNF-alpha-induced cyclooxygenase-2 expression by Mycobacterium bovis BCG in human alveolar epithelial A549 cells. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23147035&form=6&db=m Cholera toxin induces a shift from inactive to active cyclooxygenase 2 in alveolar macrophages activated by Mycobacterium bovis BCG. ongoing research,unassigned 2,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24907510&form=6&db=m Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-?B pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27776487&form=6&db=m The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection. causal interaction,ongoing research,unassigned 3,1,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28576719&form=6&db=m Phenolic derivatives from Blaps japanensis and their biological evaluation. unassigned -
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29373690&form=6&db=m Novel Function of Cyclooxygenase-2: Suppressing Mycobacteria by Promoting Autophagy via the Protein Kinase B/Mammalian Target of Rapamycin Pathway. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30202030&form=6&db=m Adjunctive use of celecoxib with anti-tuberculosis drugs: evaluation in a whole-blood bactericidal activity model. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31396568&form=6&db=m Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32956876&form=6&db=m Nonpeptidal compounds from the insect Polyphaga plancyi and their biological evaluation. ongoing research,unassigned 3,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33155730&form=6&db=m Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors. causal interaction,unassigned 3,0
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33787849&form=6&db=m The landscape of different molecular modules in an immune microenvironment during tuberculosis infection. unassigned -
1.14.99.1 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34307194&form=6&db=m Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients. therapeutic application,unassigned 2,0
1.14.99.1 Tuberculosis, Multidrug-Resistant http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19380835&form=6&db=m Matrix metalloproteinase-1 is regulated in tuberculosis by a p38 MAPK-dependent, p-aminosalicylic acid-sensitive signaling cascade. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Tuberculosis, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16634800&form=6&db=m A combination of a transforming growth factor-beta antagonist and an inhibitor of cyclooxygenase is an effective treatment for murine pulmonary tuberculosis. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28684424&form=6&db=m IL-4 up-regulates cyclooxygenase-1 expression in macrophages. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Tuberous Sclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29384235&form=6&db=m miR147b: A novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes. causal interaction,unassigned 1,0
1.14.99.1 Typhlitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3898232&form=6&db=m Prevention of cecitis in hamsters by certain prostaglandins. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Typhoid Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=106313&form=6&db=m Pyrogenic renal hyperemia: the role of prostaglandins. causal interaction,diagnostic usage,unassigned 2,1,0
1.14.99.1 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1948751&form=6&db=m [The level of thromboxane A2 and prostacyclin in patients with chronic kidney failure undergoing hemodialysis] causal interaction,unassigned 1,0
1.14.99.1 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3108321&form=6&db=m Aspirin prolongs bleeding time in uremia by a mechanism distinct from platelet cyclooxygenase inhibition. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3138744&form=6&db=m Prostaglandin synthetase inhibitors are not beneficial in the hypercatabolic state of acute uremia in rats. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6298281&form=6&db=m Reduced platelet thromboxane formation in uremia. Evidence for a functional cyclooxygenase defect. causal interaction,diagnostic usage,unassigned 4,1,0
1.14.99.1 Uremia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21335517&form=6&db=m Cyclooxygenase 2 promotes parathyroid hyperplasia in ESRD. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=118489&form=6&db=m Increased renal tubular synthesis of prostaglandins in the rabbit kidney in response to ureteral obstruction. ongoing research,unassigned 4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3930905&form=6&db=m Increase in enzyme activities of prostaglandin biosynthesis and catabolism by acute ureteral ligation in rat kidney. ongoing research,unassigned 2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7938055&form=6&db=m Effects of dietary protein on glomerular eicosanoid production in rats with bilateral ureteral obstruction. ongoing research,unassigned 3,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8390688&form=6&db=m Increases in glomerular eicosanoid production in rats with bilateral ureteral obstruction are mediated by enhanced enzyme activities of both the cyclooxygenase and 5-lipoxygenase pathways. causal interaction,unassigned 3,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10072261&form=6&db=m Ureteral obstruction reverses glomerular proliferation in immune complex glomerulonephritis. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11490310&form=6&db=m Does cyclooxygenase-2 inhibitor prevent renal tissue damage in unilateral ureteral obstruction? causal interaction,diagnostic usage,ongoing research,unassigned 1,3,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12187272&form=6&db=m Cyclooxygenase-2 expression is up-regulated in obstructed human ureter. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12654237&form=6&db=m [The renal protective effect of selective cyclooxygenase-2 inhibitor on obstructive nephropathy] ongoing research,unassigned 1,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14501778&form=6&db=m Regional expression of cyclooxygenase isoforms in the rat kidney in complete unilateral ureteral obstruction. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14718596&form=6&db=m Suppression of 15-hydroxyprostaglandin dehydrogenase messenger RNA concentration, protein expression, and enzymatic activity during human ureteral obstruction. ongoing research,unassigned 4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15538275&form=6&db=m Cyclooxygenase-2 inhibitor preserves medullary aquaporin-2 expression and prevents polyuria after ureteral obstruction. causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15840770&form=6&db=m COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction. causal interaction,therapeutic application,unassigned 2,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15849480&form=6&db=m Cyclooxygenase-2 inhibitor decreases extracellular matrix synthesis in stretched renal fibroblasts. causal interaction,unassigned 4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16507712&form=6&db=m Evaluation of urothelial stretch-induced cyclooxygenase-2 expression in novel human cell culture and porcine in vivo ureteral obstruction models. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16820795&form=6&db=m Cyclooxygenase type 2 is increased in obstructed rat and human ureter and contributes to pelvic pressure increase after obstruction. ongoing research,therapeutic application,unassigned 4,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17229676&form=6&db=m COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19193137&form=6&db=m Evaluation of urothelial stretch-induced cyclooxygenase-2 expression in a mouse ureteral obstruction model. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20107111&form=6&db=m Cyclooxygenase 2 inhibition exacerbates AQP2 and pAQP2 downregulation independently of V2 receptor abundance in the postobstructed kidney. ongoing research,unassigned 3,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20147610&form=6&db=m Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20610829&form=6&db=m Increased cyclooxygenase-2 expression and prostaglandin E2 production in pressurized renal medullary interstitial cells. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20958135&form=6&db=m NS-398 (a Selective Cyclooxygenase-2 Inhibitor) Decreases Agonist-Induced Contraction of the Human Ureter via Calcium Channel Inhibition. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22397925&form=6&db=m Disruption of cyclooxygenase-2 prevents down-regulation of cortical AQP2 and AQP3 in response to bilateral ureteral obstruction in the mouse. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22398203&form=6&db=m Alteration of renal cyclooxygenase expression due to partial unilateral ureteral obstruction in neonatal. causal interaction,unassigned 4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22513820&form=6&db=m The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22998445&form=6&db=m PI3K mediates stretch-induced COX-2 expression during urinary tract obstruction. ongoing research,unassigned 4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24226522&form=6&db=m ROS dependence of cyclooxygenase-2 induction in rats subjected to unilateral ureteral obstruction. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25553102&form=6&db=m Chitosan/siRNA nanoparticles targeting cyclooxygenase type 2 attenuate unilateral ureteral obstruction-induced kidney injury in mice. diagnostic usage,ongoing research,unassigned 2,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25776498&form=6&db=m Role of cyclooxygenase-2 in the development of interstitial fibrosis in kidneys following unilateral ureteral obstruction in mice. causal interaction,ongoing research,unassigned 3,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25810437&form=6&db=m Quercetin attenuates cyclooxygenase-2 expression in response to acute ureteral obstruction. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26458764&form=6&db=m Circadian CLOCK Mediates Activation of Transforming Growth Factor-? Signaling and Renal Fibrosis through Cyclooxygenase 2. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26661655&form=6&db=m Role of COX-2 in Unilateral Ureteral Obstruction: What Is New? causal interaction,unassigned 4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26671967&form=6&db=m Disruption of cyclooxygenase type 2 exacerbates apoptosis and renal damage during obstructive nephropathy. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Ureteral Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31386888&form=6&db=m Prediction of the mechanisms of action of shenkang in chronic kidney disease: A network pharmacology study and experimental validation. ongoing research,unassigned 1,0
1.14.99.1 Urethral Stricture http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16360446&form=6&db=m Use of cyclooxygenase-2 inhibitor for prevention of urethral strictures secondary to transurethral resection of the prostate. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Urinary Bladder Neck Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9362331&form=6&db=m Cyclooxygenase-2 is expressed in bladder during fetal development and stimulated by outlet obstruction. causal interaction,unassigned 3,0
1.14.99.1 Urinary Bladder Neck Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15705100&form=6&db=m The restorative effect of a selective cyclooxygenase-2 inhibitor on urothelial cell-cell interactions after partial bladder outlet obstruction in rats. ongoing research,therapeutic application,unassigned 4,3,0
1.14.99.1 Urinary Bladder Neck Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16253314&form=6&db=m Ultrastructural and immunohistochemical analysis of rat uroepithelial cell junctions after partial bladder outlet obstruction and selective COX-2 inhibitor treatment. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Urinary Bladder Neck Obstruction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25265830&form=6&db=m The influence of piroxicam, a non-selective cyclooxygenase inhibitor, on autonomic nervous system activity in experimental cyclophosphamide-induced hemorrhagic cystitis and bladder outlet obstruction in rats. ongoing research,therapeutic application,unassigned 2,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6184169&form=6&db=m Interferon induction and prostaglandin synthetase inhibition in the in vitro and in vivo manipulation of immune response expression in an animal model of bladder cancer. ongoing research,unassigned 4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6424934&form=6&db=m Metabolic activation of carcinogenic aromatic amines by dog bladder and kidney prostaglandin H synthase. diagnostic usage,unassigned 3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6790163&form=6&db=m Aspirin inhibition of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced lesions of the urinary bladder correlated with inhibition of metabolism by bladder prostaglandin endoperoxide synthetase. causal interaction,unassigned 3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10582676&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10590224&form=6&db=m Increased expression of cyclooxygenase-2 protein in rat urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine. diagnostic usage,ongoing research,unassigned 1,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10874020&form=6&db=m The role of cyclooxygenase enzymes in the growth of human gall bladder cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10880372&form=6&db=m Enhanced expression of cyclooxygenase-2 in high grade human transitional cell bladder carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11059745&form=6&db=m Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11238034&form=6&db=m Expression of cyclooxygenase-2 in human transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11310210&form=6&db=m Interferon-alpha inhibits cyclooxygenase-1 and stimulates cyclooxygenase-2 expression in bladder cancer cells in vitro. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11342898&form=6&db=m Expression of cyclooxygenase-2 in patients with bladder carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11694654&form=6&db=m Diet and cancer prevention studies in p53-deficient mice. causal interaction,ongoing research,therapeutic application,unassigned 1,4,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11769882&form=6&db=m An introduction to aspirin, NSAids, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis: part II. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11809678&form=6&db=m Effects of the cyclooxygenase inhibitor, piroxicam, on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11827414&form=6&db=m Expression of cyclooxygenase-1 and -2 in urinary bladder carcinomas in vivo and in vitro and prostaglandin E2 synthesis in cultured bladder cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11851614&form=6&db=m Cyclooxygenase-2: a possible target in schistosoma-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11982590&form=6&db=m Prostaglandin E2 down-regulates viable Bacille Calmette-Guérin-induced macrophage cytotoxicity against murine bladder cancer cell MBT-2 in vitro. ongoing research,unassigned 3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12197220&form=6&db=m Influence of cigarette smoking on prostaglandin synthesis and cyclooxygenase-2 gene expression in human urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12269772&form=6&db=m Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder compared to normal adjacent tissue. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12270783&form=6&db=m Chemoprevention of superficial bladder cancer. therapeutic application,unassigned 3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12352459&form=6&db=m Prostaglandin E2 production and cyclooxygenase-2 induction in human urinary tract infections and bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12429306&form=6&db=m Association of cyclooxygenase-2 expression with prognosis of stage T1 grade 3 bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,2
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12442003&form=6&db=m Synergistic cytotoxicity and apoptosis of JTE-522, a selective cyclooxygenase-2 inhibitor, and 5-fluorouracil against bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12526218&form=6&db=m [Expression of cyclooxygenase-2 in human transitional cell bladder carcinomas] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12576466&form=6&db=m Clinical evaluation of mitoxantrone and piroxicam in a canine model of human invasive urinary bladder carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12589035&form=6&db=m Effects of the cyclooxygenase inhibitor, piroxicam, in combination with chemotherapy on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer. causal interaction,ongoing research,therapeutic application,unassigned 1,4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12607607&form=6&db=m A modified reduced-temperature antigen retrieval protocol effective for use with a polyclonal antibody to cyclooxygenase-2 (PG 27). diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12913755&form=6&db=m Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12917512&form=6&db=m Bladder cancer prevention. Part I: what do I tell my patients about lifestyle changes and dietary supplements? causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12930427&form=6&db=m Cyclooxygenase-2 promotes angiogenesis in pTa/T1 urothelial bladder carcinoma but does not predict recurrence. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12954496&form=6&db=m Cytokeratin 20, AN43, PGDH, and COX-2 expression in transitional and squamous cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14566678&form=6&db=m Expression of cyclooxygenase-2 in primary superficial bladder cancer tissue may predict risk of its recurrence after complete transurethral resection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14601561&form=6&db=m Association of cyclooxygenase-2 expression with prognosis of state T1 grade 3 bladder cancer. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14667515&form=6&db=m Cyclooxygenase-2 expression in bladder cancer: correlation with poor outcome after chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,3
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14713756&form=6&db=m Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138613&form=6&db=m The effects of cyclooxygenase-2 inhibitors on urological cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15145695&form=6&db=m COX-2 inhibition demonstrates potent anti-proliferative effects on bladder cancer in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15240520&form=6&db=m A cox-2 promoter-based replication-selective adenoviral vector to target the cox-2-expressing human bladder cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15371874&form=6&db=m Enhanced sensitivity of bladder cancer cells to cisplatin mediated cytotoxicity and apoptosis in vitro and in vivo by the selective cyclooxygenase-2 inhibitor JTE-522. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15459875&form=6&db=m [Cyclooxygenase-2-expression in bladder cancer: tumor-biological and clinical implications] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15491687&form=6&db=m Rationale for use of cyclooxygenase-2 inhibitors in prevention and treatment of bladder cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15498296&form=6&db=m [The significance of the expression of cyclooxygenase-2 in bladder transitional cell carcinoma tissues] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546559&form=6&db=m Synergistic effects of Cox-1 and -2 inhibition on bladder and prostate cancer in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15596291&form=6&db=m Polymorphism in the nuclear factor kappa-B binding promoter region of cyclooxygenase-2 is associated with an increased risk of bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15664302&form=6&db=m Pretreatment tumor prostaglandin E2 concentration and cyclooxygenase-2 expression are not associated with the response of canine naturally occurring invasive urinary bladder cancer to cyclooxygenase inhibitor therapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15753378&form=6&db=m Transitional cell hyperplasia and carcinomas in urinary bladders of transgenic mice with keratin 5 promoter-driven cyclooxygenase-2 overexpression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,3
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15870865&form=6&db=m Cox-2 and Her2/neu co-expression in invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15947685&form=6&db=m Cyclooxygenase-2 inhibition: a potential mechanism for increasing the efficacy of bacillus calmette-guerin immunotherapy for bladder cancer. therapeutic application,unassigned 4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16000874&form=6&db=m COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16010419&form=6&db=m High-throughput tissue microarray analysis of COX2 expression in urinary bladder cancer. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16127634&form=6&db=m American Urological Association--94th annual meeting. 1-6 May 1999, Dallas, USA. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16132759&form=6&db=m Cyclooxygenase-2 expression increases with the stage and grade in transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16218400&form=6&db=m [Relationship between cyclooxygenase (COX)-2 and malignant tumors] causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16391871&form=6&db=m Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16401921&form=6&db=m Relation between cyclooxygenase-2 expression and clinicopathologic parameters with patient prognosis in transitional cell carcinoma of the bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16505106&form=6&db=m Cyclooxygenase inhibitors in urinary bladder cancer: in vitro and in vivo effects. therapeutic application,unassigned 4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16573762&form=6&db=m Cohort study of COX-1 and COX-2 expression in canine rectal and bladder tumours. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,3
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16596191&form=6&db=m Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells. ongoing research,unassigned 4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16724691&form=6&db=m Association of cyclooxygenase-2 immunoreactivity with tumor recurrence and disease progression in superficial urothelial bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16903934&form=6&db=m Inhibition of 5-lipoxygenase pathway suppresses the growth of bladder cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17093206&form=6&db=m Mitogenic signal transduction caused by monomethylarsonous acid in human bladder cells: role in arsenic-induced carcinogenesis. causal interaction,unassigned 4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17296438&form=6&db=m Expression of cyclooxygenase-2 in normal urothelium, and superficial and advanced transitional cell carcinoma of bladder. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17430655&form=6&db=m [Effects of selective cyclooxygenase-2 inhibitor on proliferation and apoptosis of human bladder cancer cell line T24] causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18222600&form=6&db=m Celecoxib has potent antitumour effects as a single agent and in combination with BCG immunotherapy in a model of urothelial cell carcinoma. therapeutic application,unassigned 4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18242386&form=6&db=m Etodolac, a selective cyclooxygenase-2 inhibitor, induces upregulation of E-cadherin and has antitumor effect on human bladder cancer cells in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367112&form=6&db=m Forced COX-2 expression induces PGE(2) and invasion in immortalized urothelial cells. causal interaction,unassigned 4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18413803&form=6&db=m Cyclooxygenase-2 dependent and independent antitumor effects induced by celecoxib in urinary bladder cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18449376&form=6&db=m Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18562222&form=6&db=m Canine invasive transitional cell carcinoma cell lines: In vitro tools to complement a relevant animal model of invasive urinary bladder cancer. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18617357&form=6&db=m In vitro and in vivo inhibitory effect evaluation of cyclooxygenase-2 inhibitors, antisense cyclooxygenase-2 cDNA, and their combination on the growth of human bladder cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19287971&form=6&db=m Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,3
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19372053&form=6&db=m Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19415693&form=6&db=m Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice. therapeutic application,unassigned 1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19571668&form=6&db=m Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyclooxygenase-2 inhibition as chemoprevention for rat bladder carcinogenesis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,1,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19682434&form=6&db=m Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers. causal interaction,unassigned 3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20204301&form=6&db=m p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20423998&form=6&db=m Effects of Short-term Celecoxib Treatment in Patients with Invasive Transitional Cell Carcinoma of the Urinary Bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20428812&form=6&db=m Potential of molecular targeted therapy of HER-2 and Cox-2 for invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20503476&form=6&db=m Brucea javanica oil induces apoptosis in T24 bladder cancer cells via upregulation of caspase-3, caspase-9, and inhibition of NF-kappaB and COX-2 expressions. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20582552&form=6&db=m Reciprocal correlation between the expression of cyclooxygenase-2 and E-cadherin in human bladder transitional cell carcinomas. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20627335&form=6&db=m Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for urinary bladder cancer in North India. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21105986&form=6&db=m Bilharzial vs non-bilharzial related bladder cancer: pathological characteristics and value of cyclooxygenase-2 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,1
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21166751&form=6&db=m Improved cancer specific-survival in patients with carcinoma invading bladder muscle expressing cyclo-oxygenase-2. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,3
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21206978&form=6&db=m Heme oxygenase-1 promotes angiogenesis in urothelial carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21403827&form=6&db=m Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21479487&form=6&db=m Cyclooxygenase-2 expression in invasive transitional cell carcinoma of the urinary bladder. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21592330&form=6&db=m Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2? contributes to human bladder cancer cell survival. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21750550&form=6&db=m In vitro and in vivo inhibitory effect of three Cox-2 inhibitors and epithelial-to-mesenchymal transition in human bladder cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 3,4,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21881030&form=6&db=m A randomized controlled trial of celecoxib to prevent recurrence of nonmuscle-invasive bladder cancer. diagnostic usage,therapeutic application,unassigned 3,2,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21896649&form=6&db=m Boxing bladder cancer with COX-2-specific inhibition. ongoing research,therapeutic application,unassigned 3,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22288910&form=6&db=m Cyclooxygenase-2 Expression Is Up-regulated by 2-Aminobiphenyl in a ROS and MAPK-Dependent Signaling Pathway in a Bladder Cancer Cell Line. causal interaction,ongoing research,unassigned 4,2,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22577245&form=6&db=m Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23028744&form=6&db=m Cyclooxygenase-2 expression in bladder cancer and patient prognosis: results from a large clinical cohort and meta-analysis. causal interaction,diagnostic usage,unassigned 3,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23376440&form=6&db=m Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction. causal interaction,unassigned 3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23946495&form=6&db=m Enhanced inhibition of urinary bladder cancer growth and muscle invasion by allyl isothiocyanate and celecoxib in combination. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24324075&form=6&db=m Associations of cyclooxygenase 2 polymorphic genotypes with bladder cancer risk in Taiwan. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24357935&form=6&db=m Study of Arachidonic Acid Pathway in Human Bladder Tumor. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24553301&form=6&db=m Significance of uroplakin III expression in recurrence of solitary muscle non-invasive bladder cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24818724&form=6&db=m The role of inflammation in bladder cancer. causal interaction,ongoing research,unassigned 4,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24989010&form=6&db=m Chalcone derivatives inhibit human platelet aggregation and inhibit growth in human bladder cancer cells. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25109742&form=6&db=m Enforced expression of miR-101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase-2 pathway. ongoing research,unassigned 3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25196524&form=6&db=m Artesunate induces apoptosis of bladder cancer cells by miR-16 regulation of COX-2 expression. therapeutic application,unassigned 1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25520883&form=6&db=m Prostaglandin receptors EP1-4 as a potential marker for clinical outcome in urothelial bladder cancer. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25638160&form=6&db=m Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1. therapeutic application,unassigned 1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25721249&form=6&db=m Suppressive Effect of Matrine on Tumor Invasion in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Urinary Bladder Carcinogenesis. therapeutic application,unassigned 1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26064295&form=6&db=m Cyclooxygenase-2 polymorphisms and bladder cancer risk: a meta-analysis based on case-control studies. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26622316&form=6&db=m Celecoxib for the prevention of nonmuscle invasive bladder cancer: results from a matched control study. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27241143&form=6&db=m [Mechanisms for effect of osthole on inhibiting the growth and invasion of bladder cancer cells]. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27706018&form=6&db=m Controls of Nuclear Factor-Kappa B Signaling Activity by 5'-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28123555&form=6&db=m Pathological significance and prognostic implications of heme oxygenase 1 expression in non-muscle-invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX-2. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29942116&form=6&db=m Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29964012&form=6&db=m Transactivation of PTGS2 by PAX5 signaling potentiates cisplatin resistance in muscle-invasive bladder cancer cells. therapeutic application,unassigned 1,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30482227&form=6&db=m Inhibition of TPL2 by interferon-? suppresses bladder cancer through activation of PDE4D. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31443756&form=6&db=m Can intravesical application of paracetamol benefit the chemotherapy treatment of bladder cancer? causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31497247&form=6&db=m Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,4
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31775672&form=6&db=m Detection of carcinogen-induced bladder cancer by fluorocoxib A. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32144049&form=6&db=m Effects of Bladder Cancer on UK Healthcare Costs and Patient Health-Related Quality of Life: Evidence From the BOXIT Trial. therapeutic application,unassigned 2,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32392774&form=6&db=m Immunotherapy in Bladder Cancer: Current Methods and Future Perspectives. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32565941&form=6&db=m Pathological roles of c-Met in bladder cancer: Association with cyclooxygenase-2, heme oxygenase-1, vascular endothelial growth factor-A and programmed death ligand 1. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32655828&form=6&db=m The role of adipocytokines and their receptors in bladder cancer: expression of adiponectin or leptin is an independent prognosticator. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33238953&form=6&db=m The role of antibody expression and their association with bladder cancer recurrence: a single-centre prospective clinical-pilot study in 35 patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34141803&form=6&db=m Pelvic lipomatosis with cystitis glandularis managed with cyclooxygenase-2 inhibitor: A case report. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Urinary Bladder, Overactive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16879691&form=6&db=m Effects of intravesical instillation of cyclooxygenase-2 inhibitor on the expression of inducible nitric oxide synthase and nerve growth factor in cyclophosphamide-induced overactive bladder. ongoing research,unassigned 3,0
1.14.99.1 Urinary Calculi http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3720020&form=6&db=m Prostaglandin synthetase inhibition with indomethacin rectal suppositories in the treatment of acute and chronic urinary calculus obstruction. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Urinary Incontinence http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19243816&form=6&db=m Expression of cyclooxygenase-2 in the canine lower urinary tract with regard to the effects of gonadal status and gender. diagnostic usage,unassigned 1,0
1.14.99.1 Urinary Retention http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12187239&form=6&db=m Acute urinary retention associated with the use of cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Urinary Retention http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32307385&form=6&db=m [TYPICAL TYPE CYSTITIS GLANDULARIS PRESENTING URINARY RETENTION IN A YOUNG MAN: ADJUVANT THERAPY USING ORAL CYCLOOXYGENASE-2 INHIBITOR: A CASE REPORT]. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Urinary Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12352459&form=6&db=m Prostaglandin E2 production and cyclooxygenase-2 induction in human urinary tract infections and bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Urogenital Abnormalities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14623548&form=6&db=m Breast cancer prevention--clinical trials strategies involving aromatase inhibitors. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Urogenital Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12352459&form=6&db=m Prostaglandin E2 production and cyclooxygenase-2 induction in human urinary tract infections and bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Urogenital Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15179622&form=6&db=m COX-2 inhibitors and other nonsteroidal anti-inflammatory drugs in genitourinary cancer. diagnostic usage,therapeutic application,unassigned 1,4,0
1.14.99.1 Urogenital Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546559&form=6&db=m Synergistic effects of Cox-1 and -2 inhibition on bladder and prostate cancer in vitro. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Urogenital Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15711257&form=6&db=m COX-2 inhibitors and other nonsteroidal anti-inflammatory drugs in genitourinary cancer. therapeutic application,unassigned 4,0
1.14.99.1 Urolithiasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16311770&form=6&db=m An animal model of calcium oxalate urolithiasis based on a cyclooxygenase 2 selective inhibitor. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Urologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12771797&form=6&db=m Cyclooxygenase-2 as a potential target in the prevention and treatment of genitourinary tumors: a review. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Urologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15138613&form=6&db=m The effects of cyclooxygenase-2 inhibitors on urological cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Urologic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16425990&form=6&db=m Cyclooxygenase-2: a therapeutic target for prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3552581&form=6&db=m Analgesics, allergy and asthma. unassigned -
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7316107&form=6&db=m Idiosyncrasy to pyrazolone drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,3,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8012649&form=6&db=m Asthma in children and ASA intolerance. causal interaction,unassigned 4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11570615&form=6&db=m Tolerability to new COX-2 inhibitors in NSAID-sensitive patients with cutaneous reactions. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11708434&form=6&db=m Urticaria and angioedema from cyclooxygenase-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11842312&form=6&db=m Urticaria and angioedema induced by COX-2 inhibitors. therapeutic application,unassigned 4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12444802&form=6&db=m NSAID-induced urticaria and angioedema: a reappraisal of its clinical management. causal interaction,unassigned 3,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12653769&form=6&db=m The selective cyclooxygenase-2 inhibitor rofecoxib may improve the treatment of chronic idiopathic urticaria. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12668893&form=6&db=m Cutaneous reactions to aspirin and nonsteroidal antiinflammatory drugs. therapeutic application,unassigned 4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14676074&form=6&db=m Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs. ongoing research,therapeutic application,unassigned 3,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242723&form=6&db=m Aspirin and NSAID sensitivity. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15335302&form=6&db=m Drug-induced urticaria. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15926604&form=6&db=m COX-2 selective nonsteroidal anti-inflammatory drugs: current status. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15967068&form=6&db=m Mechanism of chronic urticaria exacerbation by aspirin. therapeutic application,unassigned 3,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15969659&form=6&db=m Oral aspirin challenges in patients with a history of intolerance to single non-steroidal anti-inflammatory drugs. therapeutic application,unassigned 3,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16136765&form=6&db=m Safety of etoricoxib, a new cyclooxygenase 2 inhibitor, in patients with nonsteroidal anti-inflammatory drug-induced urticaria and angioedema. causal interaction,ongoing research,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16937749&form=6&db=m Use of ketoprofen oral challenges to detect cross-reactors among patients with a history of aspirin-induced urticaria. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17291297&form=6&db=m Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug (NSAID) in Japanese patients with NSAID-induced urticaria and/or angioedema: Comparison of meloxicam, etodolac and tiaramide. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18842291&form=6&db=m Clinical course and urinary eicosanoids in patients with aspirin-induced urticaria followed up for 4 years. therapeutic application,unassigned 4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20519889&form=6&db=m Analgesics. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20525150&form=6&db=m Clinical management of adult patients with a history of nonsteroidal anti-inflammatory drug-induced urticaria/angioedema: update. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21039786&form=6&db=m Safety of meloxicam in patients with aspirin/non-steroidal anti-inflammatory drug-induced urticaria and angioedema. therapeutic application,unassigned 3,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21192625&form=6&db=m Cetirizine premedication prevents acute urticaria induced by weak COX-1 inhibitors in multiple NSAID reactors. therapeutic application,unassigned 3,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21834936&form=6&db=m Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25562554&form=6&db=m Management of patients with nonaspirin-exacerbated respiratory disease aspirin hypersensitivity reactions. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27372601&form=6&db=m H1-Antihistamine Premedication in NSAID-Associated Urticaria. therapeutic application,unassigned 4,0
1.14.99.1 Urticaria http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29384107&form=6&db=m Restoration of aspirin tolerance following omalizumab treatment in a patient with chronic spontaneous urticaria. therapeutic application,unassigned 3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7589737&form=6&db=m Clinical evaluations of a new ovarian cancer marker, COX-1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,3
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10684704&form=6&db=m High cyclooxygenase-2 expression in stage IB cervical cancer with lymph node metastasis or parametrial invasion. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11156216&form=6&db=m Expression of metastases-associated genes in cervical cancers resected in the proliferative and secretory phases of the menstrual cycle. diagnostic usage,unassigned 1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11234900&form=6&db=m Cyclooxygenase-2 is overexpressed in human cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11344234&form=6&db=m Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11605045&form=6&db=m Association between overexpression of cyclooxygenase-2 and suppression of apoptosis in advanced cancer of the uterine cervix after cyclic balloon-occluded arterial infusion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11844819&form=6&db=m Increased cyclooxygenase-2 expression is associated with chemotherapy resistance and poor survival in cervical cancer patients. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,2,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12402155&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in tumour and stroma compartments in cervical cancer: clinical implications. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,3
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504031&form=6&db=m High cyclooxygenase-2 expression is related with distant metastasis in cervical cancer treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12504032&form=6&db=m Cyclooxygenase-2 (COX-2) expression in locally advanced cervical cancer patients undergoing chemoradiation plus surgery. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,2,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12648590&form=6&db=m High cyclooxygenase-2 expression in cervical adenocarcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12748469&form=6&db=m Expression of cyclooxygenase-2 in cervical, endometrial, and ovarian malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,2,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795050&form=6&db=m The role of COX-2 in breast and cervical cancer. ongoing research,unassigned 4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12795056&form=6&db=m Potential for combined modality therapy of cyclooxygenase inhibitors and radiation. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12821346&form=6&db=m Expression of cyclooxygenase-1 and -2 associated with expression of VEGF in primary cervical cancer and at metastatic lymph nodes. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12829126&form=6&db=m Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) negatively affect overall survival in carcinoma of the cervix treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12902860&form=6&db=m COX-2 inhibitor as a radiation enhancer: new strategies for the treatment of lung cancer. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14532998&form=6&db=m Overexpression of cyclooxygenase-2 protein and its relationship to apoptosis in cervical carcinoma treated with neoadjuvant chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534699&form=6&db=m Cyclooxygenase-2 expression in lymph node metastasis of cervical and vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555502&form=6&db=m Celecoxib modulates the expression of cyclooxygenase-2, ki67, apoptosis-related marker, and microvessel density in human cervical cancer: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14555539&form=6&db=m Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766253&form=6&db=m Cyclooxygenase-2 expression predicts recurrence of cervical dysplasia following loop electrosurgical excision procedure. ongoing research,unassigned 2,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14977838&form=6&db=m Synchronous coexpression of epidermal growth factor receptor and cyclooxygenase-2 in carcinomas of the uterine cervix: a potential predictor of poor survival. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15131052&form=6&db=m Prognostic role of the ratio between cyclooxygenase-2 in tumor and stroma compartments in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15197583&form=6&db=m Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-kappaB as a possible target. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15368588&form=6&db=m Evaluation of tissue-specific promoters in carcinomas of the cervix uteri. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15465199&form=6&db=m Differential cyclooxygenase-2 expression in squamous cell carcinoma and adenocarcinoma of the uterine cervix. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15539913&form=6&db=m Concomitant radiochemotherapy plus surgery in locally advanced cervical cancer: update of clinical outcome and cyclooxygenase-2 as predictor of treatment susceptibility. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15627842&form=6&db=m Evaluation of expression of apoptosis-related proteins and their correlation with HPV, telomerase activity, and apoptotic index in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,4,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15863127&form=6&db=m Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15936552&form=6&db=m Coexpression of cyclooxygenase-2 and thymidine phosphorylase as a prognostic indicator in patients with FIGO stage IIB squamous cell carcinoma of uterine cervix treated with radiotherapy and concurrent chemotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16099602&form=6&db=m Increased expression of nitric oxide synthase and cyclooxygenase-2 is associated with poor survival in cervical cancer treated with radiotherapy. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,3,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16246405&form=6&db=m Prevalence and prognostic significance of COX-2 expression in stage IB cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16979845&form=6&db=m Cyclooxygenase-2 impairs treatment effects of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17013750&form=6&db=m Expression of cyclooxygenase-2 related to angiogenesis in uterine cervical cancers. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404026&form=6&db=m Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17415111&form=6&db=m Cyclooxygenase 2 expression in cervical intraepithelial neoplasia and vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17440114&form=6&db=m Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange. ongoing research,unassigned 3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17466271&form=6&db=m Celecoxib induces apoptosis by inhibiting the expression of survivin in HeLa cells. ongoing research,therapeutic application,unassigned 4,1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17544005&form=6&db=m In regard to Ishikawa et al.: Cyclooxygenase-2 impairs treatment effect of radiotherapy for cervical cancer by inhibition of radiation-induced apoptosis (Int J Radiat Oncol Biol Phys 2006;66:1347-1355). therapeutic application,unassigned 4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17549374&form=6&db=m VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro. diagnostic usage,ongoing research,unassigned 3,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17578348&form=6&db=m Hypermethylation of the COX-2 gene is a potential prognostic marker for cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17581404&form=6&db=m Cyclooxygenase-2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17601662&form=6&db=m Influences of cyclooxygenase-1 and -2 expression on the radiosensitivities of human cervical cancer cell lines. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17671679&form=6&db=m Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17828511&form=6&db=m The expression of cyclooxygenase-2 in cervical cancers and Hela cells was regulated by estrogen/progestogen. ongoing research,unassigned 4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17919838&form=6&db=m Cyclooxygenase-2 expression as a predictor of para-aortic lymph node recurrence in uterine cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18275990&form=6&db=m Cyclooxygenase-2 in cervical neoplasia: a review. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18565574&form=6&db=m Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18849297&form=6&db=m Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells. therapeutic application,unassigned 1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18977022&form=6&db=m Cyclooxygenase-2 expression in squamous cell carcinoma of the uterine cervix is associated with lymph node metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19015962&form=6&db=m R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. ongoing research,unassigned 4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19058955&form=6&db=m Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19203995&form=6&db=m Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19399588&form=6&db=m COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells. ongoing research,unassigned 4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19809548&form=6&db=m Acute toxicity of cyclooxygenase-2 inhibitor rofecoxib as a radiosensitizer for concurrent chemoradiation in the treatment of uterine cervical cancer. therapeutic application,unassigned 4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19949677&form=6&db=m The effect of cyclooxygenase-2 expression on tumor volume response in patients treated with radiotherapy for uterine cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,2
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20015862&form=6&db=m Human papillomavirus type 16 E5 protein inhibits hydrogen-peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells. therapeutic application,unassigned 1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20192574&form=6&db=m Cyclooxygenase-2 Expression in Cervical Squamous Cell Carcinoma: the Significance of Expression in Neoplastic Cells within the Lymphovascular Space. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20686383&form=6&db=m Cyclooxygenase-2 gene polymorphisms and risk of cervical cancer in a North Indian population. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21195874&form=6&db=m Prognostic cell biological markers in cervical cancer patients primarily treated with (chemo)radiation: a systematic review. causal interaction,diagnostic usage,unassigned 4,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21208204&form=6&db=m Activation of the interleukin-32 pro-inflammatory pathway in response to human papillomavirus infection and over-expression of interleukin-32 controls the expression of the human papillomavirus oncogene. diagnostic usage,ongoing research,unassigned 3,2,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21424030&form=6&db=m Immunohistochemical evaluation of COX-2 expression in HPV-positive cervical squamous intraepithelial lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,3,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21600223&form=6&db=m COX-2 expression is correlated with VEGF-C, lymphangiogenesis and lymph node metastasis in human cervical cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21946890&form=6&db=m Epidermal growth factor-stimulated human cervical cancer cell growth is associated with EGFR and cyclin D1 activation, independent of COX-2 expression levels. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22135046&form=6&db=m The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22729746&form=6&db=m Prognostic significance of cyclooxygenase-2 in cervical cancer: A meta-analysis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,1,4
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23221733&form=6&db=m COX-2 expression and survival in patients with locally advanced cervical cancer treated with chemoradiotherapy and celecoxib: a quantitative immunohistochemical analysis of RTOG C0128. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23346542&form=6&db=m Prognostic implications of tumor volume response and COX-2 expression change during radiotherapy in cervical cancer patients. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23567332&form=6&db=m Cyclooxygenase-2-prostaglandin E2-eicosanoid receptor inflammatory axis: a key player in Kaposi's sarcoma-associated herpes virus associated malignancies. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675067&form=6&db=m Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24528073&form=6&db=m Roles of MiR-101 and its target gene Cox-2 in early diagnosis of cervical cancer in Uygur women. diagnostic usage,therapeutic application,unassigned 2,1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24681731&form=6&db=m Cox-2, EGFR, and ERBB-2 Expression in Cervical Intraepithelial Neoplasia and Cervical Cancer Using an Automated Imaging System. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24787377&form=6&db=m Inflammation induced by human papillomavirus in cervical cancer and its implication in prevention. causal interaction,unassigned 4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25054026&form=6&db=m Candidate biomarkers for cervical cancer treatment: Potential for clinical practice (Review). causal interaction,diagnostic usage,unassigned 1,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25337538&form=6&db=m Cyclooxygenase-1 and -2: molecular targets for cervical neoplasia. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25370734&form=6&db=m The close correlation between heparanase and COX-2 expression in lymphangiogenesis of cervical cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25494807&form=6&db=m Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25536801&form=6&db=m Cyclooxygenase-2 expression in cervical cancer. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25734181&form=6&db=m Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25773949&form=6&db=m Crosstalk between possible cytostatic and antiinflammatory potential of ketoprofen in the treatment of culture of colon and cervix cancer cell lines. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25872337&form=6&db=m Expressions of survivin, P16(INK4a), COX-2, and Ki-67 in cervical cancer progression reveal the potential clinical application. diagnostic usage,therapeutic application,unassigned 4,2,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25874230&form=6&db=m Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells. ongoing research,unassigned 1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26257474&form=6&db=m Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Downregulates the Expression of Protumor Factors Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in a GM-CSF Receptor-Independent Manner in Cervical Cancer Cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27221835&form=6&db=m Celecoxib, a COX-2 Selective Inhibitor, Induces Cell Cycle Arrest at the G2/M Phase in HeLa Cervical Cancer Cells. ongoing research,therapeutic application,unassigned 4,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27292107&form=6&db=m Augmented Activity of Cyclooxygenase-2 in Tissue and Serum of Patients With Cervical Cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27698799&form=6&db=m Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27736969&form=6&db=m Downregulation of HOTAIR Expression Mediated Anti-Metastatic Effect of Artesunate on Cervical Cancer by Inhibiting COX-2 Expression. causal interaction,ongoing research,therapeutic application,unassigned 1,2,2,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27779652&form=6&db=m [Retracted] Epidermal growth factor-stimulated human cervical cancer cell growth is associated with EGFR and cyclin D1 activation, independent of COX-2 expression levels. causal interaction,diagnostic usage,unassigned 3,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28881683&form=6&db=m Inhibition of COX2 enhances the chemosensitivity of dichloroacetate in cervical cancer cells. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31614548&form=6&db=m Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,3,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31736008&form=6&db=m MUC16 facilitates cervical cancer progression via JAK2/STAT3 phosphorylation-mediated cyclooxygenase-2 expression. therapeutic application,unassigned 1,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31897181&form=6&db=m Transcriptome changes induced by RUNX3 in cervical cancer cells in vitro. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32363546&form=6&db=m COX-2-PGE2-EPs in gynecological cancers. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982722&form=6&db=m The Role of Eicosanoids in Gynecological Malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34320931&form=6&db=m Prediction of lymphovascular space invasion using a combination of tenascin-C, cox-2, and PET/CT radiomics in patients with early-stage cervical squamous cell carcinoma. diagnostic usage,ongoing research,therapeutic application,unassigned 3,1,2,0
1.14.99.1 Uterine Cervicitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23675067&form=6&db=m Clinicopathological Significance of VEGF-C, VEGFR-3 and Cyclooxygenase-2 in Early-Stage Cervical Cancer. diagnostic usage,ongoing research,unassigned 3,3,0
1.14.99.1 Uterine Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3102127&form=6&db=m Action of a prostaglandin synthetase inhibitor on IUD associated uterine bleeding. unassigned -
1.14.99.1 Uterine Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4064305&form=6&db=m The effect of a prostaglandin synthetase inhibitor, indomethacin, on excessive uterine bleeding. ongoing research,therapeutic application,unassigned 1,2,0
1.14.99.1 Uterine Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12414896&form=6&db=m Mifepristone-induced vaginal bleeding is associated with increased immunostaining for cyclooxygenase-2 and decrease in prostaglandin dehydrogenase in luteal phase endometrium. therapeutic application,unassigned 1,0
1.14.99.1 Uterine Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16730488&form=6&db=m Efficacy of a selective COX-2 inhibitor for controlling irregular uterine bleeding in DMPA users. therapeutic application,unassigned 4,0
1.14.99.1 Uterine Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17963179&form=6&db=m Non-contraceptive health benefits of oral contraceptives. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Uterine Hemorrhage http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23720426&form=6&db=m Cyclooxygenase-2 regulated by the nuclear factor-?B pathway plays an important role in endometrial breakdown in a female mouse menstrual-like model. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Uterine Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17044934&form=6&db=m Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,2
1.14.99.1 Uterine Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17483309&form=6&db=m The high-mobility group A1 gene up-regulates cyclooxygenase 2 expression in uterine tumorigenesis. causal interaction,ongoing research,unassigned 3,4,0
1.14.99.1 Uterine Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18645019&form=6&db=m Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Uterine Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23625281&form=6&db=m Expression of estrogen receptors (?, ?), cyclooxygenase-2 and aromatase in normal endometrium and endometrioid cancer of uterus. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Uterine Prolapse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25662613&form=6&db=m Does Uterine Prolapse Alter Endometrial Cyclooxygenase 2 Expression and Promote the Development of Premalignant Lesions? causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1324133&form=6&db=m Modulation of immune responses by cyclo-oxygenase inhibitors during intraocular inflammation. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1841575&form=6&db=m Role of interleukin 6 in the inflammatory response after cataract surgery. An experimental and clinical study. causal interaction,unassigned 3,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2508125&form=6&db=m The role of arachidonate metabolites in ocular inflammation. causal interaction,unassigned 3,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7297093&form=6&db=m Anti-inflammatory effects of betamethasone phosphate, dexamethasone phosphate and indomethacin on rabbit ocular inflammation induced by bovine serum albumin. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7729711&form=6&db=m Mediators of the ocular inflammatory response to interleukin-1 beta plus tumor necrosis factor-alpha. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8207337&form=6&db=m Steroidal and nonsteroidal drugs in endotoxin-induced uveitis. therapeutic application,unassigned 4,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9154274&form=6&db=m Cyclooxygenase-2 inhibitors: a new approach to the therapy of ocular inflammation. therapeutic application,unassigned 4,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14691168&form=6&db=m Inhibition of endotoxin-induced uveitis and potentiation of cyclooxygenase-2 protein expression by alpha-melanocyte-stimulating hormone. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22827198&form=6&db=m Topical diclofenac sodium, dexamethasone and placebo compared in a model of immunogenic uveitis in rabbits. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Uveitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29287164&form=6&db=m Cyclooxygenase-2 expression in the eyes of cats with and without uveitis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,3
1.14.99.1 Uveitis, Anterior http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7729711&form=6&db=m Mediators of the ocular inflammatory response to interleukin-1 beta plus tumor necrosis factor-alpha. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,2,0
1.14.99.1 Uveitis, Anterior http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16019677&form=6&db=m Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU). ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8114674&form=6&db=m Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. diagnostic usage,ongoing research,unassigned 1,2,0
1.14.99.1 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8143845&form=6&db=m Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15-R-HETE synthesis. ongoing research,unassigned 4,0
1.14.99.1 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8383332&form=6&db=m Poxvirus-induced alteration of arachidonate metabolism. ongoing research,unassigned 3,0
1.14.99.1 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19471247&form=6&db=m Treatment with cyclooxygenase-2 inhibitors enables repeated administration of vaccinia virus for control of ovarian cancer. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Vaccinia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19941994&form=6&db=m Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Vaginal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982722&form=6&db=m The Role of Eicosanoids in Gynecological Malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Vaginosis, Bacterial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21798373&form=6&db=m Lactobacillus johnsonii HY7042 ameliorates Gardnerella vaginalis-induced vaginosis by killing Gardnerella vaginalis and inhibiting NF-?B activation. therapeutic application,unassigned 2,0
1.14.99.1 Varicocele http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22747653&form=6&db=m Expression of cyclooxygenase-1 (COX-1) and COX-2 in human male gametes from normal patients, and those with varicocele and diabetes: a potential molecular marker for diagnosing male infertility disorders. causal interaction,diagnostic usage,ongoing research,unassigned 3,2,4,0
1.14.99.1 Varicocele http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25906828&form=6&db=m Seminal cyclooxygenase relationship with oxidative stress in infertile oligoasthenoteratozoospermic men with varicocele. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Varicose Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11745699&form=6&db=m Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Varicose Ulcer http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33768649&form=6&db=m Matrix metalloproteinase (MMP)-1 and MMP-2, but not COX-2 serve as additional predictors for chronic venous ulcer healing. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Varicose Veins http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10550185&form=6&db=m Cyclic nucleotides and production of prostanoids in human varicose veins. ongoing research,unassigned 2,0
1.14.99.1 Varicose Veins http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15191401&form=6&db=m Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18367192&form=6&db=m Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model. causal interaction,unassigned 4,0
1.14.99.1 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26543101&form=6&db=m Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Vascular Calcification http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33159018&form=6&db=m Cyclooxygenase-2/sclerostin mediates TGF-?1-induced calcification in vascular smooth muscle cells and rats undergoing renal failure. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,2,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080473&form=6&db=m 15-Hydroxy-5,8,11,13-eicosatetraenoic acid inhibits human vascular cyclooxygenase. Potential role in diabetic vascular disease. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3896560&form=6&db=m Inhibition of platelet function in thrombosis. therapeutic application,unassigned 4,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8508535&form=6&db=m Cyclooxygenase-dependent vasoconstrictor alters vascular function in the vitamin E-deprived rat. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11566042&form=6&db=m COX-1 and COX-2 inhibitors. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11805196&form=6&db=m Cyclooxygenase isozyme expression and intimal hyperplasia in a rat model of balloon angioplasty. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11982732&form=6&db=m Management of peptic ulcer disease not related to Helicobacter. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12215479&form=6&db=m Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. unassigned -
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12388637&form=6&db=m Angiotensin II increases expression of cyclooxygenase-2: implications for the function of vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12444207&form=6&db=m A role for uric acid in the progression of renal disease. causal interaction,diagnostic usage,unassigned 4,3,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14517215&form=6&db=m Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16154102&form=6&db=m Prostacyclin protects against elevated blood pressure and cardiac fibrosis. causal interaction,unassigned 4,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16785824&form=6&db=m Cyclooxygenase-2 inhibition and coagulation. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17855367&form=6&db=m Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases. causal interaction,unassigned 3,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18221358&form=6&db=m Residual platelet thromboxane A2 and prothrombotic effects of erythrocytes are important determinants of aspirin resistance in patients with vascular disease. causal interaction,unassigned 2,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18452714&form=6&db=m PKC-delta/c-Src-mediated EGF receptor transactivation regulates thrombin-induced COX-2 expression and PGE(2) production in rat vascular smooth muscle cells. ongoing research,therapeutic application,unassigned 2,2,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19233864&form=6&db=m Functional coupling expression of COX-2 and cPLA2 induced by ATP in rat vascular smooth muscle cells: role of ERK1/2, p38 MAPK, and NF-kappaB. causal interaction,unassigned 3,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19553934&form=6&db=m COX-1 and vascular disease. diagnostic usage,ongoing research,unassigned 4,4,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20424334&form=6&db=m Prostacyclin in vascular diseases. - Recent insights and future perspectives -. causal interaction,unassigned 2,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20543082&form=6&db=m Inducible nitric oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20938039&form=6&db=m A Randomized Trial of Aspirin at Clinically Relevant Doses and Nitric Oxide Formation in Humans. therapeutic application,unassigned 2,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22204330&form=6&db=m Potential therapeutic targeting of platelet-mediated cellular interactions in atherosclerosis and inflammation. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22595400&form=6&db=m Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: A potentially protective mechanism in atherosclerotic vascular disease and cancer. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23318226&form=6&db=m ATP stimulates PGE2/cyclin D1-dependent VSMCs proliferation via STAT3 activation: Role of PKCs-dependent NADPH oxidase/ROS generation. causal interaction,unassigned 3,0
1.14.99.1 Vascular Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23726390&form=6&db=m Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Vascular Ring http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1789998&form=6&db=m Omega-3 polyunsaturated fatty acids augment endothelium-dependent vasorelaxation by enhanced release of EDRF and vasodilator prostaglandins. therapeutic application,unassigned 4,0
1.14.99.1 Vascular Ring http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2160508&form=6&db=m Superoxide radical-mediated endothelial injury and vasoconstriction of rat thoracic aortic rings. diagnostic usage,ongoing research,unassigned 3,1,0
1.14.99.1 Vascular Ring http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6411788&form=6&db=m Comparative effects of nitroglycerin and nitroprusside on prostacyclin generation in adult human vessel wall. therapeutic application,unassigned 2,0
1.14.99.1 Vascular Ring http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21543636&form=6&db=m Disruption of COX-2 and eNOS does not confer protection from cardiovascular failure in lipopolysaccharide-treated conscious mice and isolated vascular rings. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Vascular Ring http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23401173&form=6&db=m The Lignan (-)-Cubebin Inhibits Vascular Contraction and Induces Relaxation Via Nitric Oxide Activation in Isolated Rat Aorta. therapeutic application,unassigned 1,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8018656&form=6&db=m Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8132578&form=6&db=m Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. causal interaction,unassigned 3,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8544381&form=6&db=m [Role of cyclooxygenase metabolites in the increase in pulmonary vascular permeability caused by mechanically activated white blood cells] causal interaction,unassigned 1,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9817723&form=6&db=m Effects of low-dose Beraprost sodium, a stable prostaglandin I2 analogue, on reperfusion injury to rabbit lungs. unassigned -
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10591667&form=6&db=m 25-hydroxycholesterol increases eicosanoids and alters morphology in cultured pulmonary artery smooth muscle and endothelial cells. unassigned -
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11805196&form=6&db=m Cyclooxygenase isozyme expression and intimal hyperplasia in a rat model of balloon angioplasty. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12586211&form=6&db=m Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27). causal interaction,therapeutic application,unassigned 3,2,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14638539&form=6&db=m Cyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17998477&form=6&db=m Maintaining equilibrium by selective targeting of cyclooxygenase pathways: promising offensives against vascular injury. therapeutic application,unassigned 4,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19783781&form=6&db=m Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23973752&form=6&db=m Cadmium exposure induces vascular injury due to endothelial oxidative stress: the role of local angiotensin II and COX-2. causal interaction,ongoing research,therapeutic application,unassigned 2,4,1,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27803479&form=6&db=m Analysis of Vascular Cell Response to Hypertension Induced by Pressure Loading and Its Application as a Tool for Exploring Pharmacological Modes of Action. diagnostic usage,unassigned 3,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28024294&form=6&db=m Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic rats. causal interaction,unassigned 4,0
1.14.99.1 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34078818&form=6&db=m Abnormal Pressure Stress Reduces Interleukin-1?-Induced Cyclooxygenase-2 Expression in Cultured Rat Vascular Smooth Muscle Cells. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Vasculitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15926604&form=6&db=m COX-2 selective nonsteroidal anti-inflammatory drugs: current status. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6337914&form=6&db=m Prostaglandin metabolism and prostacyclin in cerebral vasospasm. therapeutic application,unassigned 1,0
1.14.99.1 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6767998&form=6&db=m Cerebral vasospasm: effects of prostaglandin synthetase inhibitors in vitro. ongoing research,unassigned 4,0
1.14.99.1 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9471105&form=6&db=m Contractions induced by NO synthase inhibition in isolated rat basilar artery: role of the endothelium and endogenous vasoconstrictors. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Vasospasm, Intracranial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27044361&form=6&db=m Role of Cyclooxygenase-2 in Relation to Nitric Oxide and Endothelin-1 on Pathogenesis of Cerebral Vasospasm After Subarachnoid Hemorrhage in Rabbit. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Venous Thromboembolism http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25748877&form=6&db=m Cardiovascular risks associated with non-aspirin non-steroidal anti-inflammatory drug use. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0
1.14.99.1 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28536720&form=6&db=m Prostaglandin-endoperoxide synthase-2 deletion affects the natural trafficking of Annexin A2 in monocytes and favours venous thrombosis in mice. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Venous Thrombosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29784076&form=6&db=m Analgesic Efficacy and Hematologic Effects of Robenacoxib in Mice. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,3,0
1.14.99.1 Ventilator-Induced Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21048090&form=6&db=m Cyclooxygenase Inhibition in Ventilator-Induced Lung Injury. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Ventilator-Induced Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23587488&form=6&db=m Effects of COX-2 inhibitor on ventilator-induced lung injury in rats. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Ventilator-Induced Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445238&form=6&db=m Hydrogen Sulfide Confers Lung Protection During Mechanical Ventilation via Cyclooxygenase 2, 15-deoxy ?12,14-Prostaglandin J2, and Peroxisome Proliferator-Activated Receptor Gamma. therapeutic application,unassigned 1,0
1.14.99.1 Ventilator-Induced Lung Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30974834&form=6&db=m Cyclooxygenase-2 Activity Regulates Recruitment of VEGF-Secreting Ly6Chigh Monocytes in Ventilator-Induced Lung Injury. unassigned -
1.14.99.1 Ventricular Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3142241&form=6&db=m Modulation of arachidonic acid metabolites and vulnerability to ventricular fibrillation during myocardial ischemia in the cat. ongoing research,unassigned 4,0
1.14.99.1 Ventricular Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18241971&form=6&db=m Non-selective cyclooxygenase inhibition before periodic acceleration (pGz) cardiopulmonary resuscitation (CPR) in a porcine model of ventricular fibrillation. therapeutic application,unassigned 1,0
1.14.99.1 Ventricular Fibrillation http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31734378&form=6&db=m Cyclooxygenase inhibition prior to ventricular fibrillation induced ischemia reperfusion injury impairs survival and outcomes. causal interaction,ongoing research,therapeutic application,unassigned 1,2,4,0
1.14.99.1 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6330977&form=6&db=m Reversible restriction of vesicular stomatitis virus in permissive cells treated with inhibitors of prostaglandin biosynthesis. ongoing research,therapeutic application,unassigned 3,2,0
1.14.99.1 Vesicular Stomatitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11021993&form=6&db=m NSAID treatment suppresses VSV propagation in mouse CNS. ongoing research,therapeutic application,unassigned 2,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2119789&form=6&db=m The prophylactic use of cyclooxygenase inhibitors in recurrent herpes simplex infections. therapeutic application,unassigned 4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2539425&form=6&db=m Reversal of virus-induced alveolar macrophage bactericidal dysfunction by cyclooxygenase inhibition in vitro. causal interaction,unassigned 3,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2693369&form=6&db=m Aspirin-induced asthma: new insights into pathogenesis and clinical presentation of drug intolerance. causal interaction,unassigned 2,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8755638&form=6&db=m Viral infection induces dependence of neuronal M2 muscarinic receptors on cyclooxygenase in guinea pig lung. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9809499&form=6&db=m Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma. causal interaction,unassigned 4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12009531&form=6&db=m Theiler's virus infection induces the expression of cyclooxygenase-2 in murine astrocytes: inhibition by the anti-inflammatory cytokines interleukin-4 and interleukin-10. therapeutic application,unassigned 1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12195364&form=6&db=m Beneficial effect of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with asthma during viral infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12517975&form=6&db=m Regulation of cyclooxygenase-2 expression by macrophages in response to double-stranded RNA and viral infection. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767669&form=6&db=m Effects of MF-tricyclic, a selective cyclooxygenase-2 inhibitor, on atherosclerosis progression and susceptibility to cytomegalovirus replication in apolipoprotein-E knockout mice. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14733733&form=6&db=m The role and regulation of COX-2 during viral infection. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15471864&form=6&db=m The viral protein A238L inhibits cyclooxygenase-2 expression through a nuclear factor of activated T cell-dependent transactivation pathway. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15479690&form=6&db=m Increased intrahepatic cyclooxygenase 2, matrix metalloproteinase 2, and matrix metalloproteinase 9 expression is associated with progressive liver disease in chronic hepatitis C virus infection: role of viral core and NS5A proteins. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15512958&form=6&db=m Acetylsalicylic acid reduces viral shedding induced by thermal stress. causal interaction,therapeutic application,unassigned 3,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16051851&form=6&db=m Role of inflammatory cytokine-induced cyclooxygenase 2 in the ocular immunopathologic disease herpetic stromal keratitis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16272346&form=6&db=m Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. causal interaction,ongoing research,unassigned 4,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16914119&form=6&db=m The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE(2) release in murine brain-derived endothelial cells following Theiler's virus infection. causal interaction,ongoing research,therapeutic application,unassigned 1,3,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16920983&form=6&db=m Role of MAPK in the regulation of double-stranded RNA- and encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. causal interaction,ongoing research,therapeutic application,unassigned 3,4,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16991002&form=6&db=m Amino acids 1 to 422 of the spike protein of SARS associated coronavirus are required for induction of cyclooxygenase-2. ongoing research,unassigned 4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17161422&form=6&db=m Eicosanoids mediate Galleria mellonella cellular immune response to viral infection. causal interaction,therapeutic application,unassigned 2,1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17964630&form=6&db=m NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. causal interaction,unassigned 4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18092051&form=6&db=m Expression of cyclooxygenase-2 and transforming growth factor-beta1 in HCV-induced chronic liver disease and hepatocellular carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18315734&form=6&db=m Comparison of expression profiles induced by dust mite in airway epithelia reveals a common pathway. causal interaction,unassigned 1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18414668&form=6&db=m Activation of interleukin-32 pro-inflammatory pathway in response to influenza A virus infection. causal interaction,ongoing research,therapeutic application,unassigned 3,3,2,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18565510&form=6&db=m Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,4,1
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19004559&form=6&db=m New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19886038&form=6&db=m Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. causal interaction,therapeutic application,unassigned 4,2,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19941994&form=6&db=m Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. causal interaction,ongoing research,therapeutic application,unassigned 4,2,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20121401&form=6&db=m Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20375625&form=6&db=m Phosphatidylinositol 3-kinase regulates macrophage responses to double-stranded RNA and encephalomyocarditis virus. causal interaction,ongoing research,therapeutic application,unassigned 4,3,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20505008&form=6&db=m Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages. causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20657653&form=6&db=m Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20880066&form=6&db=m Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,1,2
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21354125&form=6&db=m High-throughput screen of protein expression levels induced by cyclooxygenase-2 during influenza a virus infection. unassigned -
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22072783&form=6&db=m Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22622947&form=6&db=m EICOSANOIDS MEDIATE CELLULAR IMMUNE RESPONSE AND PHENOLOXIDASE REACTION TO VIRAL INFECTION IN ADULT Pimpla turionellae. causal interaction,unassigned 4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23775184&form=6&db=m Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors. causal interaction,unassigned 1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23850620&form=6&db=m Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23946454&form=6&db=m Soluble interleukin-6 receptor-mediated innate immune response to DNA and RNA viruses. unassigned -
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26408666&form=6&db=m CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 3,2,1,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28317866&form=6&db=m Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,4
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31022559&form=6&db=m Original research article Parainfluenza virus infection enhances NSAIDs-induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31366713&form=6&db=m Prostaglandin E2-Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti-PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection. causal interaction,ongoing research,therapeutic application,unassigned 2,2,4,0
1.14.99.1 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32508794&form=6&db=m Cyclooxygenase-2 Facilitates Newcastle Disease Virus Proliferation and Is as a Target for Canthin-6-One Antiviral Activity. causal interaction,therapeutic application,unassigned 3,1,0
1.14.99.1 Vitamin E Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6419199&form=6&db=m A reexamination of the role of oxygen in retrolental fibroplasia. causal interaction,unassigned 3,0
1.14.99.1 Vitamin E Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6766501&form=6&db=m The effects of vitamin E depletion and repletion on prostaglandin synthesis in semitendinosus muscle of young rabbits. causal interaction,unassigned 1,0
1.14.99.1 Vitamin E Deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6806455&form=6&db=m In vitro and in vivo effects of vitamin E on arachidonic acid metabolism in rat platelets. unassigned -
1.14.99.1 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21625016&form=6&db=m Expression of IL-17 and COX2 Gene in Peripheral Blood Leukocytes of Vitiligo Patients. causal interaction,unassigned 3,0
1.14.99.1 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23555779&form=6&db=m Vitiligo: a possible model of degenerative diseases. causal interaction,ongoing research,unassigned 2,4,0
1.14.99.1 Vitiligo http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29094684&form=6&db=m Study of the relation between two common cyclooxygenase 2 gene polymorphisms with risk of developing and subtypes of vitiligo in Egyptian patients. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Vitreoretinopathy, Proliferative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7813591&form=6&db=m Fibroblast growth-promoting activity in proliferative vitreoretinopathy: antagonism by acetylsalicylic acid. causal interaction,therapeutic application,unassigned 4,1,0
1.14.99.1 von Willebrand Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6429881&form=6&db=m A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer. causal interaction,diagnostic usage,unassigned 1,3,0
1.14.99.1 von Willebrand Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14602548&form=6&db=m Platelet function tests using platelet aggregometry: need for repetition of the test for diagnosis of defective platelet function. diagnostic usage,unassigned 3,0
1.14.99.1 Vulvar Lichen Sclerosus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17560634&form=6&db=m The role of angiogenesis and COX-2 expression in the evolution of vulvar lichen sclerosus to squamous cell carcinoma of the vulva. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,3,0
1.14.99.1 Vulvar Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14534699&form=6&db=m Cyclooxygenase-2 expression in lymph node metastasis of cervical and vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1
1.14.99.1 Vulvar Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14766245&form=6&db=m Expression of cyclooxygenase-2 (COX-2) in non-neoplastic and neoplastic vulvar epithelial lesions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1
1.14.99.1 Vulvar Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17404027&form=6&db=m Increased cyclooxygenase-2 expression associated with inflammatory cellular infiltration in elderly patients with vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Vulvar Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17413988&form=6&db=m Identification of potential prognostic markers for vulvar cancer using immunohistochemical staining of tissue microarrays. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Vulvar Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17415111&form=6&db=m Cyclooxygenase 2 expression in cervical intraepithelial neoplasia and vulvar cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4
1.14.99.1 Vulvar Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19723114&form=6&db=m Celecoxib potentiates the anticancer effect of cisplatin on vulvar cancer cells independently of cyclooxygenase. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,4
1.14.99.1 Vulvar Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32982722&form=6&db=m The Role of Eicosanoids in Gynecological Malignancies. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,2,0
1.14.99.1 Vulvar Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33802010&form=6&db=m Combined COX-2/PPAR? Expression as Independent Negative Prognosticator for Vulvar Cancer Patients. causal interaction,unassigned 3,0
1.14.99.1 Vulvar Vestibulitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11437722&form=6&db=m The expression of cyclooxygenase 2 and inducible nitric oxide synthase indicates no active inflammation in vulvar vestibulitis. causal interaction,diagnostic usage,unassigned 4,2,0
1.14.99.1 Vulvitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17393766&form=6&db=m Vulvar fixed drug eruption. A report of 13 cases. causal interaction,therapeutic application,unassigned 1,2,0
1.14.99.1 Warts http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19462903&form=6&db=m [VEGF, COX-2 and MVD in lesions of patients with condyloma acuminatum] causal interaction,unassigned 4,0
1.14.99.1 Wasting Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18996358&form=6&db=m The significance of the nongenomic pathway in mediating inflammatory signaling of the dioxin-activated Ah receptor to cause toxic effects. causal interaction,therapeutic application,unassigned 3,3,0
1.14.99.1 Water Intoxication http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11102561&form=6&db=m COX-2 and the kidneys. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Wernicke Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18481165&form=6&db=m Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide. causal interaction,ongoing research,therapeutic application,unassigned 4,2,2,0
1.14.99.1 Wernicke Encephalopathy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21930349&form=6&db=m Immunohistochemical expression of proinflammatory cytokines IL-1?, IL-6, TNF-? and involvement of COX-2, quantitatively confirmed by Western blot analysis, in Wernicke's encephalopathy. diagnostic usage,unassigned 3,0
1.14.99.1 West Nile Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21106803&form=6&db=m Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes. causal interaction,ongoing research,therapeutic application,unassigned 2,4,4,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1371994&form=6&db=m Signal transduction by tumor necrosis factor alpha is mediated through a guanine nucleotide-binding protein in osteoblast-like cell line, MC3T3-E1. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1415557&form=6&db=m Role of endothelin-1 in regulating proliferation of cultured rabbit airway smooth muscle cells. therapeutic application,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1647255&form=6&db=m The bradykinin receptor--a putative receptor-operated channel in PC12 cells: studies of neurotransmitter release and inositol phosphate accumulation. unassigned -
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1688553&form=6&db=m Histidine regulation of cyclic AMP metabolism in cultured renal epithelial LLC-PK1 cells. therapeutic application,unassigned 2,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1845801&form=6&db=m Glucose transport stimulation by bradykinin in Swiss 3T3 fibroblasts: a pertussis toxin-sensitive mechanism operates without involvement of arachidonic acid and cyclic AMP. ongoing research,therapeutic application,unassigned 3,1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1850750&form=6&db=m Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells: II. A pathway involving arachidonic acid release, prostaglandin synthesis, and cyclic AMP accumulation. therapeutic application,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2105889&form=6&db=m Pertussis toxin and H-7 distinguish mechanisms involved in eicosanoid release from lipopolysaccharide-primed macrophages. Eicosanoid release from lipopolysaccharide-primed macrophages. ongoing research,therapeutic application,unassigned 1,3,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2187055&form=6&db=m Astrocytes are target cells for endothelins and sarafotoxin. therapeutic application,unassigned 3,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3141420&form=6&db=m Generation of inositol phosphates, cytosolic Ca2+, and ionic fluxes in PC12 cells treated with bradykinin. therapeutic application,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7615808&form=6&db=m Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA. diagnostic usage,ongoing research,therapeutic application,unassigned 2,3,4,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7706373&form=6&db=m Mechanical stimulation of skeletal muscle increases prostaglandin F2 alpha production, cyclooxygenase activity, and cell growth by a pertussis toxin sensitive mechanism. causal interaction,ongoing research,unassigned 1,3,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8179336&form=6&db=m Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes. therapeutic application,unassigned 2,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8460710&form=6&db=m Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. ongoing research,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9237867&form=6&db=m Endothelin-1 stimulates the release of arachidonic acid and prostaglandins in cultured human ciliary muscle cells: activation of phospholipase A2. therapeutic application,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9244176&form=6&db=m Mastoparan elicits prostaglandin E2 generation and inhibits inositol phosphate accumulation via different mechanisms in rabbit astrocytes. causal interaction,therapeutic application,unassigned 1,4,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10980258&form=6&db=m Endogenous cannabinoid anandamide directly inhibits voltage-dependent Ca(2+) fluxes in rabbit T-tubule membranes. therapeutic application,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11527419&form=6&db=m R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism. unassigned -
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11829737&form=6&db=m Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression. therapeutic application,unassigned 3,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12369781&form=6&db=m Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells. ongoing research,unassigned 2,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15136060&form=6&db=m Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDL. therapeutic application,unassigned 2,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15659311&form=6&db=m Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta. diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16386710&form=6&db=m Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. ongoing research,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16877527&form=6&db=m Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. diagnostic usage,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17382352&form=6&db=m Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17704831&form=6&db=m Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. causal interaction,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17766482&form=6&db=m The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway. therapeutic application,unassigned 4,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17921818&form=6&db=m Identification of the vasodilatory endothelial cannabinoid receptor in the human pulmonary artery. therapeutic application,unassigned 2,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17927697&form=6&db=m Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1). causal interaction,therapeutic application,unassigned 4,3,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18534982&form=6&db=m Endocannabinoid 2-arachidonoylglycerol protects neurons by limiting COX-2 elevation. unassigned -
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18802115&form=6&db=m Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells. causal interaction,ongoing research,unassigned 1,4,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18958425&form=6&db=m Regulation of lysophosphatidic acid-induced COX-2 expression by ERK1/2 activation in cultured feline esophageal epithelial cells. unassigned -
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19636412&form=6&db=m CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration. causal interaction,therapeutic application,unassigned 4,4,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20814065&form=6&db=m Ghrelin signaling in human mesenteric arteries. therapeutic application,unassigned 2,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21488197&form=6&db=m Effect of pertussis toxin and herbimycin A on proteinase-activated receptor 2-mediated cyclooxygenase 2 expression in Helicobacter pylori-infected gastric epithelial AGS cells. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22504059&form=6&db=m Moderate hypothermia attenuates ?(1)-adrenoceptor-mediated contraction in isolated rat aorta: the role of the endothelium. therapeutic application,unassigned 3,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23041148&form=6&db=m Contrary effects of sphingosine-1-phosphate on expression of ?-smooth muscle actin in transforming growth factor ?1-stimulated lung fibroblasts. causal interaction,unassigned 1,0
1.14.99.1 Whooping Cough http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24265450&form=6&db=m EP2 receptor activates dual G protein signaling pathways that mediate contrasting proinflammatory and relaxatory responses in term pregnant human myometrium. unassigned -
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15526363&form=6&db=m Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. causal interaction,therapeutic application,unassigned 1,1,0
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618763&form=6&db=m Inhibition of Cyclooxygenase-2 Disrupts Tumor Vascular Mural Cell Recruitment and Survival Signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16945639&form=6&db=m Expression of cyclooxygenase-2 in Wilms tumor: immunohistochemical study using tissue microarray methodology. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16962507&form=6&db=m Inhibition of cyclooxygenase-2 disrupts tumor vascular mural cell recruitment and survival signaling Lee A, Frischer J, Serur A, Huang J, Bae JO, Kornfield ZN, Eljuga L, Shawber CJ, Feirt N, Mansukhani M, Stempak D, Baruchel S, Bender JG, Kandel JJ, Yamashiro DJ, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,1
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18752906&form=6&db=m Analysis of Cox-2 expression in Wilms' tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19157443&form=6&db=m S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21145881&form=6&db=m Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves ?v?5 integrin, ILK and AP-1-dependent pathways. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25973014&form=6&db=m Nephroblastoma overexpressed gene (NOV) enhances RCC cell motility through upregulation of ICAM-1 and COX-2 expression via Akt pathway. causal interaction,ongoing research,unassigned 4,1,0
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28254151&form=6&db=m Role of Cyclooxygenase-2 Pathway in Creating an Immunosuppressive Microenvironment and in Initiation and Progression of Wilms' Tumor. causal interaction,therapeutic application,unassigned 2,4,0
1.14.99.1 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33713389&form=6&db=m Importance of COX-2 expression in Wilms' tumour: A preliminary study. ongoing research,unassigned 2,0
1.14.99.1 Wiskott-Aldrich Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3107119&form=6&db=m A novel arachidonic acid metabolite with stimulatory effect on PHA-induced mitogenesis of lymphocytes. unassigned -
1.14.99.1 Wiskott-Aldrich Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14743394&form=6&db=m Differentially up-regulated genes in proliferating porcine neonatal pancreas cells caused by epidermal growth factor. causal interaction,unassigned 1,0
1.14.99.1 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10608532&form=6&db=m Burn injury with infection alters prostaglandin E2 synthesis and metabolism. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1
1.14.99.1 Wound Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22927813&form=6&db=m A Novel Virulence Strategy for Pseudomonas aeruginosa Mediated by an Autotransporter with Arginine-Specific Aminopeptidase Activity. unassigned -
1.14.99.1 Xanthomatosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28946145&form=6&db=m Impact of Cyclooxygenase-2 1195 G-Carrier Genotype Associated with Intestinal Metaplasia and Endoscopic Findings Based on Kyoto Classification. causal interaction,diagnostic usage,therapeutic application,unassigned 2,2,1,0
1.14.99.1 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16407418&form=6&db=m Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients. unassigned -
1.14.99.1 Xeroderma Pigmentosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29697282&form=6&db=m The Role of Genetic Variants in the Association between Dietary Acrylamide and Advanced Prostate Cancer in the Netherlands Cohort Study on Diet and Cancer. causal interaction,diagnostic usage,unassigned 2,3,0
1.14.99.1 Xerostomia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24685748&form=6&db=m Candidate chromosome 1 disease susceptibility genes for Sjogren's syndrome xerostomia are narrowed by novel NOD.B10 congenic mice. ongoing research,therapeutic application,unassigned 2,1,0
1.14.99.1 Zellweger Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8261630&form=6&db=m Cyclooxygenase pathway in dermal fibroblasts from patients with metabolic disorders of peroxisomal origin. causal interaction,ongoing research,unassigned 2,1,0