1.14.12.17 Acquired Immunodeficiency Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17403602&form=6&db=m Vitreoscilla hemoglobin aids respiration under hypoxic conditions in its native host. causal interaction,ongoing research,unassigned 2,2,0 1.14.12.17 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22025306&form=6&db=m Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 1.14.12.17 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27431913&form=6&db=m Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence. causal interaction,ongoing research,unassigned 4,2,0 1.14.12.17 Adenomatous Polyposis Coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22461647&form=6&db=m Prolonged sampling of spontaneous sputum improves sensitivity of hypermethylation analysis for lung cancer. diagnostic usage,ongoing research,unassigned 3,2,0 1.14.12.17 Atherosclerosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28954528&form=6&db=m Recombinant Human Cytoglobin Prevents Atherosclerosis by Regulating Lipid Metabolism and Oxidative Stress. ongoing research,therapeutic application,unassigned 4,2,0 1.14.12.17 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20705062&form=6&db=m Cerebral expression of neuroglobin and cytoglobin after deep hypothermic circulatory arrest in neonatal piglets. unassigned - 1.14.12.17 Brain Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23585565&form=6&db=m Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model. ongoing research,unassigned 2,0 1.14.12.17 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20958924&form=6&db=m Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.12.17 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25781201&form=6&db=m Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells. unassigned - 1.14.12.17 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450577&form=6&db=m Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 1.14.12.17 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26617531&form=6&db=m Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts. causal interaction,unassigned 1,0 1.14.12.17 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26841790&form=6&db=m Dynamic features of carboxy cytoglobin distal mutants investigated by molecular dynamics simulations. unassigned - 1.14.12.17 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29720595&form=6&db=m Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice. causal interaction,ongoing research,unassigned 1,2,0 1.14.12.17 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568272&form=6&db=m Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 1.14.12.17 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22025306&form=6&db=m Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 1.14.12.17 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23111707&form=6&db=m Molecular Staging of Surgical Margins in Oral Squamous Cell Carcinoma Using Promoter Methylation of p16(INK4A), Cytoglobin, E-cadherin, and TMEFF2. diagnostic usage,therapeutic application,unassigned 2,1,0 1.14.12.17 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441751&form=6&db=m Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.12.17 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30365183&form=6&db=m Cytoglobin ameliorates the stemness of hepatocellular carcinoma via coupling oxidative-nitrosative stress signals. therapeutic application,unassigned 1,0 1.14.12.17 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16698880&form=6&db=m Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer. causal interaction,unassigned 3,0 1.14.12.17 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568272&form=6&db=m Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 1.14.12.17 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441751&form=6&db=m Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.12.17 Cardiotoxicity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33299300&form=6&db=m Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats. causal interaction,unassigned 2,0 1.14.12.17 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29720595&form=6&db=m Cytoglobin affects tumorigenesis and the expression of ulcerative colitis-associated genes under chemically induced colitis in mice. causal interaction,ongoing research,unassigned 1,2,0 1.14.12.17 Colitis, Ulcerative http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21472683&form=6&db=m Cytoglobin expression of rectal subepithelial myofibroblasts: Significant alterations of cytoglobin+ stromal cells in long-standing ulcerative colitis. unassigned - 1.14.12.17 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33611811&form=6&db=m Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells. therapeutic application,unassigned 1,0 1.14.12.17 Communicable Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20691663&form=6&db=m Flavohemoglobin and nitric oxide detoxification in the human protozoan parasite Giardia intestinalis. diagnostic usage,therapeutic application,unassigned 3,1,0 1.14.12.17 Cystitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34390071&form=6&db=m Edaravone mitigates hemorrhagic cystitis by modulating Nrf2, TLR-4/NF-?B, and JAK1/STAT3 signaling in cyclophosphamide-intoxicated rats. therapeutic application,unassigned 1,0 1.14.12.17 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11181739&form=6&db=m Optimization of immunogold labeling TEM. An ELISA-based method for rapid and convenient simulation of processing conditions for quantitative detection of antigen. diagnostic usage,ongoing research,unassigned 1,3,0 1.14.12.17 Diabetic Nephropathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28099346&form=6&db=m Liuwei Dihuang pill treats diabetic nephropathy in rats by inhibiting of TGF-?/SMADS, MAPK, and NF-kB and upregulating expression of cytoglobin in renal tissues. causal interaction,ongoing research,unassigned 1,1,0 1.14.12.17 Down Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25713607&form=6&db=m The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 1.14.12.17 Fatty Liver http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32330605&form=6&db=m TGF-?1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. causal interaction,ongoing research,unassigned 1,1,0 1.14.12.17 Fatty Liver, Alcoholic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649799&form=6&db=m Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin. causal interaction,ongoing research,unassigned 2,2,0 1.14.12.17 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24379112&form=6&db=m Hypoxia differentially upregulates the expression of embryonic, fetal and adult hemoglobin in human glioblastoma cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,4,0 1.14.12.17 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21631290&form=6&db=m Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.12.17 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23688241&form=6&db=m The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.12.17 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568272&form=6&db=m Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 1.14.12.17 Hereditary Complement Deficiency Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12892849&form=6&db=m Genetic engineering of Enterobacter aerogenes with the Vitreoscilla hemoglobin gene: cell growth, survival, and antioxidant enzyme status under oxidative stress. therapeutic application,unassigned 2,0 1.14.12.17 Infarction, Middle Cerebral Artery http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22750003&form=6&db=m Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain. ongoing research,therapeutic application,unassigned 3,4,0 1.14.12.17 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18786935&form=6&db=m Hemoglobin and its derived peptides may play a role in the antibacterial mechanism of the vagina. diagnostic usage,ongoing research,therapeutic application,unassigned 4,4,2,0 1.14.12.17 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19374926&form=6&db=m Proteomic analysis of fungal host factors differentially expressed by Fusarium graminearum infected with Fusarium graminearum virus-DK21. causal interaction,unassigned 4,0 1.14.12.17 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20399845&form=6&db=m Role of flavohemoglobin in combating nitrosative stress in uropathogenic Escherichia coli - Implications for urinary tract infection. therapeutic application,unassigned 2,0 1.14.12.17 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20410090&form=6&db=m {alpha}1-Acid glycoprotein, hepcidin, C-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosoma haematobium. diagnostic usage,unassigned 4,0 1.14.12.17 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27443280&form=6&db=m Hemoglobin LjGlb1-1 is involved in nodulation and regulates the level of nitric oxide in the Lotus japonicus-Mesorhizobium loti symbiosis. unassigned - 1.14.12.17 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34093504&form=6&db=m A Nitric Oxide-Responsive Transcriptional Regulator NsrR Cooperates With Lrp and CRP to Tightly Control the hmpA Gene in Vibrio vulnificus. ongoing research,therapeutic application,unassigned 1,1,0 1.14.12.17 Keloid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31341152&form=6&db=m Role of Hypoxia Inducible Factor-1 Alpha (HIF-1?) in Cytoglobin Expression and Fibroblast Proliferation of Keloids. causal interaction,ongoing research,unassigned 1,2,0 1.14.12.17 Keratoderma, Palmoplantar, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510494&form=6&db=m Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression. unassigned - 1.14.12.17 Keratoderma, Palmoplantar, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16698880&form=6&db=m Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer. causal interaction,unassigned 3,0 1.14.12.17 Keratoderma, Palmoplantar, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22359545&form=6&db=m Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 1.14.12.17 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18940239&form=6&db=m Localization and expression pattern of cytoglobin in carbon tetrachloride-induced liver fibrosis. ongoing research,unassigned 1,0 1.14.12.17 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21818635&form=6&db=m Cytoglobin Exhibits Anti-Fibrosis Activity on Liver In Vivo and In Vitro. causal interaction,unassigned 4,0 1.14.12.17 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665792&form=6&db=m Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway. causal interaction,ongoing research,unassigned 4,3,0 1.14.12.17 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26300973&form=6&db=m Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling. unassigned - 1.14.12.17 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26554615&form=6&db=m Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases. causal interaction,unassigned 3,0 1.14.12.17 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29852187&form=6&db=m Targeting Keap-1/Nrf-2 pathway and cytoglobin as a potential protective mechanism of diosmin and pentoxifylline against cholestatic liver cirrhosis. therapeutic application,unassigned 3,0 1.14.12.17 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30552362&form=6&db=m Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 1.14.12.17 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32492766&form=6&db=m Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis. causal interaction,unassigned 4,0 1.14.12.17 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33576020&form=6&db=m Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species. ongoing research,therapeutic application,unassigned 4,1,0 1.14.12.17 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26554615&form=6&db=m Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases. causal interaction,unassigned 3,0 1.14.12.17 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28128325&form=6&db=m Protective effects of recombinant human cytoglobin against chronic alcohol-induced liver disease in vivo and in vitro. ongoing research,therapeutic application,unassigned 4,2,0 1.14.12.17 Liver Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33649799&form=6&db=m Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin. causal interaction,ongoing research,unassigned 2,2,0 1.14.12.17 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665792&form=6&db=m Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway. causal interaction,ongoing research,unassigned 4,3,0 1.14.12.17 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677525&form=6&db=m [Hypoxia upregulates the expression of cytoglobin in lung cancer cells] causal interaction,ongoing research,unassigned 3,2,0 1.14.12.17 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16698880&form=6&db=m Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer. causal interaction,unassigned 3,0 1.14.12.17 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23591990&form=6&db=m Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 1.14.12.17 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25719833&form=6&db=m DNA hypermethylation analysis in sputum for the diagnosis of lung cancer: training validation set approach. diagnostic usage,ongoing research,unassigned 3,2,0 1.14.12.17 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26096935&form=6&db=m ?Np63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer. causal interaction,therapeutic application,unassigned 1,2,0 1.14.12.17 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27496969&form=6&db=m DNA hypermethylation analysis in sputum of asymptomatic subjects at risk for lung cancer participating in the NELSON trial: argument for maximum screening interval of 2?years. diagnostic usage,ongoing research,unassigned 2,2,0 1.14.12.17 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24722418&form=6&db=m Melanoma transition is frequently accompanied by a loss of cytoglobin expression in melanocytes: a novel expression site of cytoglobin. causal interaction,unassigned 3,0 1.14.12.17 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34035373&form=6&db=m A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma. diagnostic usage,ongoing research,unassigned 3,4,0 1.14.12.17 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16449996&form=6&db=m Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. causal interaction,diagnostic usage,unassigned 2,1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16449996&form=6&db=m Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. causal interaction,diagnostic usage,unassigned 2,1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16510494&form=6&db=m Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression. unassigned - 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16677525&form=6&db=m [Hypoxia upregulates the expression of cytoglobin in lung cancer cells] causal interaction,ongoing research,unassigned 3,2,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16698880&form=6&db=m Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer. causal interaction,unassigned 3,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18691024&form=6&db=m Cytoglobin: a novel potential gene medicine for fibrosis and cancer therapy. causal interaction,therapeutic application,unassigned 3,4,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18714394&form=6&db=m Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment? causal interaction,unassigned 1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18794132&form=6&db=m Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene. unassigned - 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568272&form=6&db=m Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20828399&form=6&db=m Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues. ongoing research,unassigned 4,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20958924&form=6&db=m Old proteins - new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21631290&form=6&db=m Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22025306&form=6&db=m Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate. causal interaction,diagnostic usage,ongoing research,unassigned 3,1,2,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22343413&form=6&db=m Protection from nitrosative stress: A central role for microbial flavohemoglobin. therapeutic application,unassigned 1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22359545&form=6&db=m Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,4,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23591990&form=6&db=m Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23688241&form=6&db=m The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23777106&form=6&db=m [Current situation and future prospect of cytoglobin research]. causal interaction,unassigned 3,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24737588&form=6&db=m Expression and biological role of cytoglobin in human ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24816917&form=6&db=m Cytoglobin in tumor hypoxia: novel insights into cancer suppression. causal interaction,ongoing research,unassigned 3,3,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25269893&form=6&db=m DNA damage induced activation of Cygb stabilizes p53 and mediates G1 arrest. unassigned - 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25275027&form=6&db=m Synergistic effects between catalase inhibitors and modulators of nitric oxide metabolism on tumor cell apoptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665792&form=6&db=m Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway. causal interaction,ongoing research,unassigned 4,3,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25781201&form=6&db=m Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells. unassigned - 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26339645&form=6&db=m Cytoglobin as a Biomarker in Cancer: Potential Perspective for Diagnosis and Management. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,4,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26554615&form=6&db=m Pathophysiological role of cytoglobin, the fourth globin in mammals, in liver diseases. causal interaction,unassigned 3,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27637274&form=6&db=m Redox and peroxidase activities of the hemoglobin superfamily - relevancy to health and disease. therapeutic application,unassigned 1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27678372&form=6&db=m The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms. causal interaction,unassigned 3,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28258342&form=6&db=m COL1A1, PRPF40A, and UCP2 correlate with hypoxia markers in non-small cell lung cancer. unassigned - 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30081385&form=6&db=m The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor. unassigned - 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30365183&form=6&db=m Cytoglobin ameliorates the stemness of hepatocellular carcinoma via coupling oxidative-nitrosative stress signals. therapeutic application,unassigned 1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450577&form=6&db=m Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30545372&form=6&db=m The epigenetically downregulated factor CYGB suppresses breast cancer through inhibition of glucose metabolism. causal interaction,unassigned 2,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920538&form=6&db=m Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-?B Pathway Inhibition. causal interaction,therapeutic application,unassigned 1,1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32087552&form=6&db=m Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase. causal interaction,therapeutic application,unassigned 4,1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441751&form=6&db=m Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33611811&form=6&db=m Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon cancer cells. therapeutic application,unassigned 1,0 1.14.12.17 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34035373&form=6&db=m A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma. diagnostic usage,ongoing research,unassigned 3,4,0 1.14.12.17 Nervous System Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27867483&form=6&db=m Brain globins in physiology and pathology. causal interaction,unassigned 3,0 1.14.12.17 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17095159&form=6&db=m Neuroglobin and cytoglobin overexpression protects human SH-SY5Y neuroblastoma cells against oxidative stress-induced cell death. ongoing research,unassigned 4,0 1.14.12.17 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17532579&form=6&db=m Anoxia or oxygen and glucose deprivation in SH-SY5Y cells: a step closer to the unraveling of neuroglobin and cytoglobin functions. ongoing research,unassigned 4,0 1.14.12.17 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25206529&form=6&db=m Overexpression of cytoglobin gene inhibits hypoxic injury to SH-SY5Y neuroblastoma cells. causal interaction,ongoing research,unassigned 1,4,0 1.14.12.17 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23160832&form=6&db=m Neuroglobin and Cytoglobin expression in the human brain. therapeutic application,unassigned 4,0 1.14.12.17 Neurodegenerative Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27637274&form=6&db=m Redox and peroxidase activities of the hemoglobin superfamily - relevancy to health and disease. therapeutic application,unassigned 1,0 1.14.12.17 Neuroinflammatory Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31920538&form=6&db=m Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-?B Pathway Inhibition. causal interaction,therapeutic application,unassigned 1,1,0 1.14.12.17 nitric oxide dioxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665792&form=6&db=m Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway. causal interaction,ongoing research,unassigned 4,3,0 1.14.12.17 nitric oxide dioxygenase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31634437&form=6&db=m Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice. causal interaction,unassigned 3,0 1.14.12.17 Non-alcoholic Fatty Liver Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25665792&form=6&db=m Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway. causal interaction,ongoing research,unassigned 4,3,0 1.14.12.17 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24737588&form=6&db=m Expression and biological role of cytoglobin in human ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.12.17 Pheochromocytoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25713607&form=6&db=m The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 1.14.12.17 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29278960&form=6&db=m Maternal cytoglobin (CYGB) serum levels in normal and preeclamptic pregnancies. diagnostic usage,therapeutic application,unassigned 2,1,0 1.14.12.17 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17267660&form=6&db=m Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect. unassigned - 1.14.12.17 Renal Insufficiency, Chronic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31910047&form=6&db=m The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease. causal interaction,therapeutic application,unassigned 3,1,0 1.14.12.17 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18353768&form=6&db=m Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro. causal interaction,ongoing research,unassigned 1,3,0 1.14.12.17 Retinal Degeneration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31634437&form=6&db=m Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice. causal interaction,unassigned 3,0 1.14.12.17 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19568272&form=6&db=m Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. causal interaction,diagnostic usage,ongoing research,unassigned 4,2,4,0 1.14.12.17 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23111707&form=6&db=m Molecular Staging of Surgical Margins in Oral Squamous Cell Carcinoma Using Promoter Methylation of p16(INK4A), Cytoglobin, E-cadherin, and TMEFF2. diagnostic usage,therapeutic application,unassigned 2,1,0 1.14.12.17 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33441751&form=6&db=m Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.12.17 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22750003&form=6&db=m Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brain. ongoing research,therapeutic application,unassigned 3,4,0 1.14.12.17 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30450577&form=6&db=m Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10348862&form=6&db=m Regulation of hmp gene transcription in Mycobacterium tuberculosis: effects of oxygen limitation and nitrosative and oxidative stress. therapeutic application,unassigned 1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11483493&form=6&db=m Mycobacterium tuberculosis hemoglobin N displays a protein tunnel suited for O2 diffusion to the heme. unassigned - 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12207698&form=6&db=m Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli. ongoing research,therapeutic application,unassigned 3,1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16846220&form=6&db=m Ligand interactions in the distal heme pocket of Mycobacterium tuberculosis truncated hemoglobin N: roles of TyrB10 and GlnE11 residues. unassigned - 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18189394&form=6&db=m Mechanism of product release in NO detoxification from Mycobacterium tuberculosis truncated hemoglobin N. ongoing research,unassigned 1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18433643&form=6&db=m Nitric oxide reactivity with globins as investigated through computer simulation. ongoing research,unassigned 2,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18676995&form=6&db=m Ligand binding to truncated hemoglobin N from Mycobacterium tuberculosis is strongly modulated by the interplay between the distal heme pocket residues and internal water. ongoing research,unassigned 2,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19003999&form=6&db=m Structural characterization of the tunnels of Mycobacterium tuberculosis truncated hemoglobin N from molecular dynamics simulations. ongoing research,unassigned 2,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19329431&form=6&db=m Role of Pre-A motif in nitric oxide scavenging by truncated hemoglobin, HbN, of mycobacterium tuberculosis. causal interaction,ongoing research,unassigned 1,2,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19948126&form=6&db=m Theoretical investigations of nitric oxide channeling in Mycobacterium tuberculosis truncated hemoglobin N. ongoing research,unassigned 1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21999759&form=6&db=m Structure and dynamics of Mycobacterium tuberculosis truncated hemoglobin N: insights from NMR spectroscopy and molecular dynamics simulations. ongoing research,therapeutic application,unassigned 1,1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22437825&form=6&db=m An unconventional hexacoordinated flavohemoglobin from Mycobacterium tuberculosis. ongoing research,unassigned 1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22773641&form=6&db=m Comparative Analysis of Mycobacterial Truncated Hemoglobin Promoters and the groEL2 Promoter in Free-Living and Intracellular Mycobacteria. unassigned - 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23145144&form=6&db=m Role of PheE15 gate in ligand entry and nitric oxide detoxification function of mycobacterium tuberculosis truncated hemoglobin N. ongoing research,unassigned 3,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23161831&form=6&db=m Oxygen migration pathways in NO-bound truncated hemoglobin. unassigned - 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23936350&form=6&db=m Isoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin N. ongoing research,unassigned 1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24861678&form=6&db=m Type I flavohemoglobin of mycobacterium smegmatis is a functional nitric oxide dioxygenase. diagnostic usage,unassigned 1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24928505&form=6&db=m Mechanistic insight into the enzymatic reduction of truncated hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A motif in electron cycling. ongoing research,unassigned 1,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25723781&form=6&db=m Molecular Model of Hemoglobin N from Mycobacterium tuberculosis Bound to Lipid Bilayers: A Combined Spectroscopic and Computational Study. ongoing research,unassigned 4,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26757411&form=6&db=m Direct Monitoring of the Reaction between Photochemically Generated Nitric Oxide and Mycobacterium tuberculosis Truncated Hemoglobin N Wild Type and Variant Forms: An Assessment of Computational Mechanistic Predictions. diagnostic usage,ongoing research,unassigned 3,2,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28358830&form=6&db=m Migration of small ligands in globins: Xe diffusion in truncated hemoglobin N. ongoing research,unassigned 3,0 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28646425&form=6&db=m Hydroxylamine-induced oxidation of ferrous carbonylated truncated hemoglobins from Mycobacterium tuberculosis and Campylobacter jejuni is limited by carbon monoxide dissociation. unassigned - 1.14.12.17 Tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28835102&form=6&db=m Mechanism of the Nitric Oxide Dioxygenase Reaction of Mycobacterium tuberculosis Hemoglobin N. ongoing research,unassigned 1,0 1.14.12.17 Urinary Tract Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20399845&form=6&db=m Role of flavohemoglobin in combating nitrosative stress in uropathogenic Escherichia coli - Implications for urinary tract infection. therapeutic application,unassigned 2,0 1.14.12.17 Vascular System Injuries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28798140&form=6&db=m The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling. ongoing research,unassigned 4,0 1.14.12.17 Wilms Tumor http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17267660&form=6&db=m Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect. unassigned -