3.4.22.53	Alzheimer Disease	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30177812&form=6&db=m	Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.	causal interaction,ongoing research,unassigned	3,2,0	
3.4.22.53	Amyotrophic Lateral Sclerosis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32937436&form=6&db=m	Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment.	unassigned	-	
3.4.22.53	Anthrax	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24085852&form=6&db=m	Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.	therapeutic application,unassigned	1,0	
3.4.22.53	Aortic Aneurysm	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19720936&form=6&db=m	Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms.	causal interaction,unassigned	1,0	
3.4.22.53	Aortic Aneurysm, Abdominal	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23977256&form=6&db=m	Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice.	causal interaction,ongoing research,therapeutic application,unassigned	2,2,2,0	
3.4.22.53	Aortic Aneurysm, Abdominal	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33761765&form=6&db=m	Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice.	causal interaction,ongoing research,therapeutic application,unassigned	2,3,1,0	
3.4.22.53	Arsenic Poisoning	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24641850&form=6&db=m	[Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25].	diagnostic usage,ongoing research,unassigned	1,3,0	
3.4.22.53	Arthritis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7632090&form=6&db=m	Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice.	causal interaction,diagnostic usage,ongoing research,therapeutic application	2,2,3,1	
3.4.22.53	Arthritis	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15501405&form=6&db=m	Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.	ongoing research,unassigned	4,0	
3.4.22.53	Arthritis, Rheumatoid	http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10600505&form=6&db=m	Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis.	causal interaction,diagnostic usage,ongoing research,unassigned	3,3,2,0