6.3.4.2	additional information	-	additional information	xanthine and related compounds inhibit CTPS activity with IC50 = 0.16-0.58 mM. The presence of an 8-oxo function enhances the inhibition to IC50 = 0.060-0.121 mM. Raising the pH from 8.0 to 8.5 results in slightly increased inhibition of NH3-dependent CTP formation by the xanthines	702613	
6.3.4.2	0.04	-	CTP	wild-type, pH 8.1, 37°C	715549	
6.3.4.2	0.042	-	CTP	wild-type, pH 8.1, 37°C	715549	
6.3.4.2	0.045	-	CTP	mutant S571A, pH 8.1, 37°C	715549	
6.3.4.2	0.05	-	CTP	IC50: 0.05 mM	649000	
6.3.4.2	0.057	-	CTP	C-terminal deletion mutant, pH 8.1, 37°C	715549	
6.3.4.2	0.06	-	uric acid	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.063	-	3,7-dimethyluric acid	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.067	-	1,3,7-trimethyluric acid	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.07	-	1,3,7-trimethyluric acid	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.072	-	1,3-dimethyluric acid	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.072	-	CTP	mutant S568A, pH 8.1, 37°C	715549	
6.3.4.2	0.079	-	1,3,7,9-tetramethyluric	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.08	-	8-oxoguanosine	-	674909	
6.3.4.2	0.08	-	8-oxoguanosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.087	-	uric acid	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.088	-	1,3-dimethyluric acid	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.09	-	3,7-dimethyluric acid	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.096	-	1-methyluric acid	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.1	-	uric acid	in HEPES buffer (70 mM, pH 7.3), at 37°C	727139	
6.3.4.2	0.101	-	1-methyluric acid	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.11	-	2,6-diaminopurine riboside	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.11	-	8-oxoguanosine 5'-triphosphate	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.113	-	1,7-dimethyluric acid	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.119	-	1,7-dimethyluric acid	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.121	-	1,3,7,9-tetramethyluric	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.13	-	8-oxoguanosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.15	-	8-oxoguanosine 5'-triphosphate	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.15	-	CTP	IC50: 0.15 mM	649000	
6.3.4.2	0.15	-	O-methylguanosine	0.30 mM Gln, IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.16	-	O-methylguanosine	10 mM Gln, IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.16	-	O-methylguanosine	2.5 mM Gln, IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.16	-	O-methylguanosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.17	-	N-methylguanosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.17	-	O-methylguanosine	0.75 mM Gln, IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.18	-	2,6-diaminopurine riboside	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.21	-	CTP	IC50 for the native enzyme: 0.12 in presence of 0.5 mM ATP, 0.22 mM in presence of 1 mM ATP. IC50 for the phosphorylated enzyme: 0.21 mM in presence of 0.5 mM ATP, 0.31 mM in presence of 1 mM ATP	648994	
6.3.4.2	0.22	-	2-aminopurine riboside	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.22	-	guanosine	5.44 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.22	-	Xanthosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.23	-	6-thioguanosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.23	-	GMP	5.44 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.23	-	N-methylguanosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.23	-	xanthine	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.25	-	GMP	2.72 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.25	-	O-methylguanosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.26	-	2-aminopurine riboside	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.26	-	GMP	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.26	-	guanosine	1.36 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.26	-	guanosine	2.72 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.28	-	GMP	1.36 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.29	-	dideoxy-GTP	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.29	-	GDP	2.72 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.29	-	GDP	5.44 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.29	-	GDP	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.29	-	GMP	8.16 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.29	-	GTP	5.44 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.29	-	guanosine	8.16 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.29	-	guanosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.29	-	Xanthosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.3	-	CTP	IC50: 0.3 mM	648973	
6.3.4.2	0.3	-	GDP	1.36 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.3	-	GTP	2.72 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.3	-	GTP	8.16 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.3	-	GTP	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.3	-	guanosine	0.30 mM Gln, IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.31	-	acycloguanosine monophosphate	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.31	-	GTP	1.36 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.32	-	CTP	IC50: 0.32 mM	648978	
6.3.4.2	0.32	-	guanosine	10 mM Gln, IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.32	-	guanosine	2.5 mM Gln, IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.32	-	guanosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.33	-	2'-deoxy-GTP	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.33	-	2'-deoxy-guanosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.33	-	acycloguanosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.33	-	GDP	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.33	-	GMP	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.33	-	guanosine 5'-tetraphosphate	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.34	-	3'-deoxy-guanosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.35	-	guanosine	0.75 mM Gln, IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.37	-	xanthine	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.38	-	guanosine	in HEPES buffer (70 mM, pH 7.3), at 37°C	727139	
6.3.4.2	0.39	-	6-thioguanine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	0.39	-	Caffeine	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.4	-	3'-deoxy-guanosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.4	-	6-thioguanosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.41	-	acycloguanosine monophosphate	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.41	-	dideoxy-GTP	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.42	-	2'-deoxy-GTP	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.42	-	guanosine 5'-tetraphosphate	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.42	-	Theobromine	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.43	-	theophylline	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.44	-	paraxanthine	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	0.45	-	2'-deoxy-guanosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.45	-	acycloguanosine	8.16 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.45	-	acycloguanosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.46	-	GTP	in HEPES buffer (70 mM, pH 7.3), at 37°C	727139	
6.3.4.2	0.47	-	acycloguanosine	5.44 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.48	-	acycloguanosine	2.72 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.48	-	Caffeine	in HEPES buffer (70 mM, pH 7.3), at 37°C	727139	
6.3.4.2	0.48	-	paraxanthine	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.49	-	acycloguanosine	1.36 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	0.51	-	Caffeine	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.55	-	theophylline	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.58	-	Theobromine	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	0.61	-	6-thioguanine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	2.6	-	uracil-4-acetic acid	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	2.9	-	ITP	8.16 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	3	-	ITP	2.72 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	3.1	-	ITP	5.44 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	3.1	-	uridine	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	3.2	-	uracil-4-acetic acid	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	3.3	-	ITP	1.36 mM NH3, IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	3.5	-	Inosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	3.7	-	ITP	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	4.1	-	ITP	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	4.2	-	Uracil	pH 8.0, Gln-dependent CTP formation	702613	
6.3.4.2	4.6	-	uridine	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	4.7	-	Uracil	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	5.2	-	Inosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	11	-	adenosine	IC50 for inhibition of Gln-dependent CTP formation	674909	
6.3.4.2	12	-	adenosine	IC50 for inhibition of NH3-dependent CTP formation	674909	
6.3.4.2	12.9	-	adenine	pH 8.0, NH3-dependent CTP formation	702613	
6.3.4.2	15.8	-	adenine	pH 8.0, Gln-dependent CTP formation	702613