1.13.11.27 additional information - 3,3,5,5-tetramethyl-2,4,6-trioxocyclohexyl 3-methylbutanoate IC50 value above 50 microM 704130 1.13.11.27 additional information - 3-(2-cyclohexylethyl)-5,5,7,7-tetramethylbenzo[d]isoxazole-4,6(5H,7H)-dione IC50 value above 50 microM 704130 1.13.11.27 additional information - 3-cyclohexyl-1-(2,4,6-trihydroxy-3-(3-methylbut-2-enyl)phenyl)propan-1-one IC50 value above 50 microM 704130 1.13.11.27 additional information - 4-(cyclohexanecarbonyl)-5-hydroxy-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione IC50 value above 50 microM 704130 1.13.11.27 additional information - 4-acetyl-5-hydroxy-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione IC50 value above 50 microM 704130 1.13.11.27 additional information - 4-dodecanoyl-5-hydroxy-2,2,6,6-tetrakis(3-methylbut-2-enyl)cyclohex-4-ene-1,3-dione IC50 value above 50 microM 704130 1.13.11.27 additional information - 5-hydroxy-4-isobutyryl-2,2,6,6-tetrakis(3-methylbut-2-enyl)cyclohex-4-ene-1,3-dione IC50 value above 50 microM 704130 1.13.11.27 additional information - additional information IC50 values: 0.015 mg/ml for manuka oil, 0.00402 mg/ml for triketone-rich fraction, 0.00314 mg/ml for leptospermone and 0.00022 mg/ml for grandiflorone 689420 1.13.11.27 0.0000013 - isoxaflutole wild-type, pH 7, 20°C 765723 1.13.11.27 0.0000013 - topramezone wild-type, pH 7, 20°C 765723 1.13.11.27 0.0000016 - topramezone mutant M335H/P336A/E363Q, pH 7, 20°C 765723 1.13.11.27 0.0000017 - sulcotrione wild-type, pH 7, 20°C 765723 1.13.11.27 0.0000018 - mesotrione wild-type, pH 7, 20°C 765723 1.13.11.27 0.0000022 - tembotrione wild-type, pH 7, 20°C 765723 1.13.11.27 0.0000025 - isoxaflutole mutant M335H/P336A/E363Q, pH 7, 20°C 765723 1.13.11.27 0.0000027 - mesotrione mutant M335H/P336A/E363Q, pH 7, 20°C 765723 1.13.11.27 0.000004 - tembotrione mutant M335H/P336A/E363Q, pH 7, 20°C 765723 1.13.11.27 0.0000041 - sulcotrione mutant M335H/P336A/E363Q, pH 7, 20°C 765723 1.13.11.27 0.0000051 - bicyclopyrone wild-type, pH 7, 20°C 765723 1.13.11.27 0.0000061 - topramezone mutant M335H/P336A/P339T/T341D/E363Q/E426Q, pH 7, 20°C 765723 1.13.11.27 0.0000068 - mesotrione mutant M335H/P336A/P339T/T341D/E363Q/E426Q, pH 7, 20°C 765723 1.13.11.27 0.0000072 - topramezone pH 7, 20°C 765723 1.13.11.27 0.0000075 - isoxaflutole mutant M335H/P336A/P339T/T341D/E363Q/E426Q, pH 7, 20°C 765723 1.13.11.27 0.0000087 - tembotrione pH 7, 20°C 765723 1.13.11.27 0.00001 - tembotrione mutant M335H/P336A/P339T/T341D/E363Q/E426Q, pH 7, 20°C 765723 1.13.11.27 0.000012 - DAS 645 pH and temperature not specified in the publication 743211 1.13.11.27 0.000012 - sulcotrione mutant M335H/P336A/P339T/T341D/E363Q/E426Q, pH 7, 20°C 765723 1.13.11.27 0.000015 - bicyclopyrone mutant M335H/P336A/E363Q, pH 7, 20°C 765723 1.13.11.27 0.000015 - topramezone enzyme isolated from Setaria faberi 689346 1.13.11.27 0.000019 - 4-decanoyl-5-hydroxy-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.00002 - DAS 645 below, pH and temperature not specified in the publication 743211 1.13.11.27 0.000021 - 1,3-diethyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.000022 - 1-ethyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.000022 - 3-ethyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1-propyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.000022 - sulcotrione pH and temperature not specified in the publication 743211 1.13.11.27 0.000023 - bicyclopyrone pH 7, 20°C 765723 1.13.11.27 0.000023 - topramezone enzyme recombinantly expressed in Arabidopsis thaliana 689346 1.13.11.27 0.000027 - mesotrione pH and temperature not specified in the publication 743211 1.13.11.27 0.000039 - 1-ethyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-propyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00004 - 5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1,3-dipropyl-1H-benzo[d]imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00004 - NTBC pH and temperature not specified in the publication 743211 1.13.11.27 0.000042 - isoxaflutole pH 7, 20°C 765723 1.13.11.27 0.000043 - bicyclopyrone mutant M335H/P336A/P339T/T341D/E363Q/E426Q, pH 7, 20°C 765723 1.13.11.27 0.000047 - 2-[3-[(4-bromophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one pH 7, 30°C 764621 1.13.11.27 0.000047 - 3-hydroxy-2-(3,5,6-trichloro-4-((4-isopropylbenzyl)amino)picolinoyl)cyclohex-2-en-1-one pH not specified in the publication, temperature not specified in the publication 764963 1.13.11.27 0.00005 - NTBC pH and temperature not specified in the publication 743211 1.13.11.27 0.000059 - 5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-methyl-1-propyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.000061 - 5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1-isopropyl-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.000062 - mesotrione pH 7, 20°C 765723 1.13.11.27 0.000063 - 2-[3-[(2,4-dichlorophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one pH 7, 30°C 764621 1.13.11.27 0.000064 - 3-ethyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1-isopropyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.000068 - 2-[3-[(3,5-dimethylphenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one pH 7, 30°C 764621 1.13.11.27 0.000068 - 2-[3-[(4-bromo-2-fluorophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one pH 7, 30°C 764621 1.13.11.27 0.00007 - 3-hydroxy-2-[3-[(4-isopropylphenyl)methoxy]-2-nitrobenzoyl]cyclohex-2-en-1-one pH 7, 30°C 764621 1.13.11.27 0.00007 - 3-hydroxy-2-[3-[(4-methylphenyl)methoxy]-2-nitrobenzoyl]cyclohex-2-en-1-one pH 7, 30°C 764621 1.13.11.27 0.000077 - 3-hydroxy-2-(3,5,6-trichloro-4-((4-methylbenzyl)amino)-picolinoyl)cyclohex-2-en-1-one pH not specified in the publication, temperature not specified in the publication 764963 1.13.11.27 0.000077 - 5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1-isopropyl-3-propyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.000085 - nitisonone pH 7, 30°C 764621 1.13.11.27 0.00009 - 2-benzyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione pH not specified in the publication, 25°C 764949 1.13.11.27 0.000091 - 2-[3-[(4-bromophenyl)methoxy]benzoyl]-3-hydroxycyclohex-2-en-1-one pH 7, 30°C 764621 1.13.11.27 0.000094 - sulcotrione pH 7, 20°C 765723 1.13.11.27 0.000095 - 2-[3-[(2,4-difluorophenyl)methoxy]-2-nitrobenzoyl]-3-hydroxycyclohex-2-en-1-one pH 7, 30°C 764621 1.13.11.27 0.0001 - 2-[(3-chlorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione pH not specified in the publication, 25°C 764949 1.13.11.27 0.0001 - 5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-2-[(3-methoxyphenyl)methyl]-1H-isoindole-1,3(2H)-dione pH not specified in the publication, 25°C 764949 1.13.11.27 0.0001 - Cyclopropyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.0001 - tert-butyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00011 - 2-[(2-chlorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione pH not specified in the publication, 25°C 764949 1.13.11.27 0.00011 - 2-[(4-bromo-2-fluorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione pH not specified in the publication, 25°C 764949 1.13.11.27 0.00012 - 2-[(4-chlorophenyl)methyl]-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-isoindole-1,3(2H)-dione pH not specified in the publication, 25°C 764949 1.13.11.27 0.00013 - 1-benzyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00013 - 1-cyclopentyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00014 - 5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1-isobutyl-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00015 - 1-tert-butyl-3-ethyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00017 - 1-butyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00017 - 4-(3-cyclohexylpropanoyl)-5-hydroxy-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.00022 - 1-cyclopropyl-3-ethyl-5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00023 - mesotrione pH not specified in the publication, 25°C 764949 1.13.11.27 0.00025 - 4-dodecanoyl-5-hydroxy-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.00025 - 5-(5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-3-methyl-1-p-tolyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.000273 - 3-hydroxy-2-(3,5,6-trichloro-4-((4-chlorobenzyl)amino)picolinoyl)cyclohex-2-en-1-one pH not specified in the publication, temperature not specified in the publication 764963 1.13.11.27 0.000273 - mesotrione pH not specified in the publication, temperature not specified in the publication 764963 1.13.11.27 0.00031 - 5-hydroxy-2,2,6,6-tetramethyl-4-palmitoylcyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.00041 - 4-(3-cyclohexylpropanoyl)-5-methoxy-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.00064 - 1-butyl-5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00067 - enzyl-5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00068 - 2-(2-nitro-4-trifluoromethylbenzoyl)cyclohexane-1,3-dione pH 7.0, 30°C, recombinant His-tagged enzyme 742451 1.13.11.27 0.00072 - 5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-1,3-dipropyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00074 - 1-ethyl-5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-propyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00075 - 5-hydroxy-2,2,6,6-tetramethyl-4-(3-phenylpropanoyl)cyclohex-4-ene-1,3-dione grandiflorone, most active naturally occurring beta-triketone 704130 1.13.11.27 0.00088 - 3-ethyl-5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-1-propyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00093 - 1-cyclopentyl-5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00094 - 1,3-diethyl-5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00094 - 5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-1-isopropyl-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00096 - 4-hexanoyl-5-hydroxy-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.00097 - 1-ethyl-5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00097 - 3-ethyl-5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-1-isopropyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00099 - 1-tert-butyl-5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-methyl-1H-benzo [d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00099 - 5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-methyl-1-p-tolyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00103 - 5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-3-methyl-1-propyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.00119 - 5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-1-isopropyl-3-propyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.0014 - pyrasulfotole pH not specified in the publication, 25°C 764949 1.13.11.27 0.00227 - 4-(3-cyclohexylpropanoyl)-5-hydroxy-2,2,6-trimethyl-6-(3-methylbut-2-enyl)cyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.00234 - benzobicyclon hydrolysate recombinant enzyme 702737 1.13.11.27 0.00249 - 4-hydroxy-6-methyl-3-[(2E)-3-phenylprop-2-enoyl]-2H-pyran-2-one pH not specified in the publication, temperature not specified in the publication 764723 1.13.11.27 0.0025 - tembotrione pH 6, 35°C 764952 1.13.11.27 0.00271 - 5-(5-hydroxy-1,3-dimethyl-1H-pyrazole-4-carbonyl)-1-isobutyl-3-methyl-1H-benzo[d] imidazol-2(3H)-one recombinant His-tagged enzyme, pH 7.0, 30°C 742451 1.13.11.27 0.0042 - mesotrione pH 6, 35°C 764952 1.13.11.27 0.0052 - topramezone pH 6, 35°C 764952 1.13.11.27 0.00675 - 4-(2,4-dichlorobenzyl)-1,3-dimethyl-5-hydroxypyrazole recombinant enzyme 702737 1.13.11.27 0.0087 - isoxaflutole pH 6, 35°C 764952 1.13.11.27 0.0118 - 5-hydroxy-2,2,6,6-tetramethyl-4-(3-methylbutanoyl)cyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.0143 - 5-hydroxy-2,2,6,6-tetramethyl-4-(2-methylbutanoyl)cyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.0189 - 5-hydroxy-2,2,6,6-tetramethyl-4-(2-phenylacetyl)cyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.0445 - 5-hydroxy-4-isobutyryl-2,2,6,6-tetramethylcyclohex-4-ene-1,3-dione - 704130 1.13.11.27 0.0731 - pinocembrin pH and temperature not specified in the publication 743564