4.3.99.3 purified His6-tagged enzyme in complex with substrate 6-carboxy-5,6,7,8-tetrahydropterin and cofactor S-adenosyl-L-methionine, X-ray diffraction structure determination and analysis at 2.2-2.6 A resolution 4.3.99.3 the crystal structure of the enzyme is determined to 2.1 A resolution by multi-wavelength anomalous dispersion 4.3.99.3 X-ray crystal structure of dimeric His6 tagged enzyme is determined to 2.55 A resolution by Multiwavelength Anomalous Dispersion