6.3.4.2 additional information - additional information - 648963, 648964 6.3.4.2 additional information - additional information inhibition kinetics. Multisite inhibition of CTPS-catalyzed NH3-dependent CTP formation by caffeine 702613 6.3.4.2 additional information - additional information kinetic mechanism, activation and inhibition kinetics 674909 6.3.4.2 additional information - additional information no saturation kinetic is obtained with S-nitroso-L-homocysteine 677028 6.3.4.2 additional information - additional information nucleotide and nucleoside analogues of GTP and guanosine, respectively, all inhibit NH3- and Gln-dependent CTP formation to a similar extent (IC50 : 0.2–0.5 mM). This inhibition appears to be due solely to the purine base and is relatively insensitive to the identity of the purine with the exception of inosine, ITP, and adenosine (IC50 : 4–12 mM). 8-Oxoguanosine is the best inhibitor identified (IC50 : 0.08 mM). 674909 6.3.4.2 0.0023 - acivicin - 674786 6.3.4.2 0.027 - S-nitroso-L-cysteine Kinact: 0.48/min 677028 6.3.4.2 0.08 - 2-Thiocytidine 5'-triphosphate pH 7.2, inhibition of glutamine reaction and ammonia reaction 648986 6.3.4.2 0.08 - CTP pH 7.2, inhibition of glutamine reaction 648986 6.3.4.2 0.09 - CTP pH 7.2, inhibition of ammonia reaction 648986 6.3.4.2 0.1 - 2-thiouridine 5'-triphosphate pH 7.2, inhibition of glutamine reaction 648986, 648993 6.3.4.2 0.12 - GTP 0.2 mM guanosine 674909 6.3.4.2 0.18 - 5-bromoUTP pH 7.2, inhibition of glutamine reaction 648986, 648993 6.3.4.2 0.182 - Gln 30°C, pH 8.0, inhibition of hydroxylamine-dependent N4-OH CTP synthesis in presence of GTP 660794 6.3.4.2 0.22 - GTP 0.1 mM guanosine 674909 6.3.4.2 0.25 - 2-thiouridine 5'-triphosphate pH 7.2, inhibition of ammonia reaction 648986, 648993 6.3.4.2 0.27 - 6-thioguanosine 5'-triphosphate - 674909 6.3.4.2 0.28 - GTP no guanosine 674909 6.3.4.2 0.29 - O-methylguanosine 5'-triphosphate - 674909 6.3.4.2 0.33 - 1-beta-D-ribofuranosyl-2-thiouracil 5'-triphosphate pH 7.2, inhibition of glutamine reaction 648986, 648993 6.3.4.2 0.36 - 2'-deoxy-GTP - 674909 6.3.4.2 0.366 - GTP 30°C, pH 8.0, inhibition of N4-OH-CTP synthesis 660794 6.3.4.2 0.39 - glutamate gamma-semialdehyde - 648963 6.3.4.2 0.5 - guanosine 5'-tetraphosphate - 674909 6.3.4.2 0.51 - s4UTP pH 7.2, inhibition of ammonia reaction 648986, 648993 6.3.4.2 0.53 - 5-bromoUTP pH 7.2, inhibition of ammonia reaction 648986, 648993 6.3.4.2 1.1 - adenylyliminodiphosphate pH 8.6 648985 6.3.4.2 3.36 - 2',3'-dialdehyde adenosine 5'-triphosphate in the presence of 10 mM UTP 672395 6.3.4.2 3.7 - 2',3'-dialdehyde adenosine 5'-triphosphate K306A: replacement of lysine 306 by alanine reduces the rate of 2',3'-dialdehyde adenosine 5'-triphosphate-dependent inactivation 672395 6.3.4.2 4.5 - ITP - 674909 6.3.4.2 5.6 - D,L-2-amino-4-phosphonobutyrate pH 8.0, reaction with ammonia 648963 6.3.4.2 11 - pyrrole-2-carboxylate pH 8.0, reaction with ammonia 648963 6.3.4.2 12.6 - L-2-pyrrolidone-5-carboxylate pH 8.0, reaction with ammonia 648963