3.5.2.16 4.5 8.5 different pH profile for cyclic ureide and cyclic imide hydrolysis 209267 3.5.2.16 7.5 8.5 shifts to more acidic pH at higher temperatures 209266 3.5.2.16 7.5 9.5 optimal pH correlates with pKa of the substrates amide proton 209268