3.4.22.49 - 664553 3.4.22.49 analysis of correlation between overexpression of separase and aneuploidy in tetracycline-inducible diploid FSK3 mouse mammary epithelial cells 700945 3.4.22.49 continuous overexpression of cmyc tagged TbSep is lethal to the cells 700280 3.4.22.49 depletion of endogenous separase with siRNA in NSCLCs shows that separase affects progression through the G2 phase of mitosis. Analysis of the effect of separase depletion on irradiated cells (cell cycle progression, M-phase fraction, late mitotic-linked cell death and clonogenic survival) 697184 3.4.22.49 enhanced cyclin-dependent kinase 1 activity due to deregulation of CDC27-anaphase-promoting complex leads in turn to hyperphosphorylation of Separase, impeding chromatid separation. Regulation of mitotic progression by transforming growth factor-beta in bone marrow stromal cells is through targeting the APC-separase pathway 700096 3.4.22.49 expressed in HEK-293T cells 707105, 732187 3.4.22.49 expressed in HeLa cells 731697, 732505 3.4.22.49 expression in Escherichia coli strain BL21(DE3) 754886 3.4.22.49 expression of myc6-separase in 293T cells 638863 3.4.22.49 expression of wild-type and C2029 mutant enzyme in 293 EcR and HeLa cells 638869