1.14.14.169 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 overall reaction. The product 6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate spontaneously lactonizes to eupatolide Helianthus annuus eupatolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O - ? 446077 1.14.14.169 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate spontaneously lactonizes to eupatolide Helianthus annuus 6alpha,8beta-dihydroxygermacra-1(10),4,11(13)-trien-12-oate + [oxidized NADPH-hemoprotein reductase] + H2O - ? 446904